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2017 Vol. 24, No. 12
Published: 2017-04-28
4
Study of the effect of Thioridazine combined with Loratadine on the gastrointestinal tumor suppressor
ZHANG Jin-mei;KANG Wen-quan;JIN Guang-yi;CHEN Ting-ting
ObjectiveTo discuss the preliminary effect of nervous system drugs on gastrointestinal tumors.MethodsThioridazine,Loratadine,Scopolamine,Dopamine,Acetylcholine and Estazolamum(0.01,0.1,1,10,100 μmol/L),six classical nervous system drugs were selected to detect the activities of gastrointestinal tumor in vitro by using CCK-8 assay.The spleen cells of mice were also used as the model to study the safety of the nervous system drugs in vitro.ResultsAmong six classical nervous system drugs,cell growth on human colon and gastric cancer clells were suppressed by 100 μmol/L scopolamine,100 μmol/L Loratadine and 10 μmol/L Thioridazine (P<0.05),especially the combination of Thioridazine and Loratadine.Six drugs only played roles in killing tumors cells,while the spleen lymphocytes of normal mice were non-toxic.The growth of mouse gastrointestinal carcinoma cells in vitro were inhibited by 10 μmol/L thioridazine and 25 μmol/L Loratadine.ConclusionThioridazine combined with Loratadine is proved to enhance anti-gastrointestinal tumor effects in vitro,and provides a new strategy for forward combination treatment.
2017 Vol. 24 (12): 4-8 [
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Effect of Pioglitazone and high glucose on the expression of p-Perilipin 1A protein in 3T3-L1 cells
XIA Wen-yan;XU Rong;FANG Xiang-nan;QIN Yong-zhang;OUYANG Long-qiang
ObjectiveTo investigate the effects of pioglitazone and high glucose on the expression of p-Perilipin 1A protein in 3T3-L1 cells.Methods3T3-L1 preadipocytes were induced and differentiated into 3T3-L1 adipocytes and then were classified into three groups：control group(5 mmol/L glucose),high glucose group(25 mmol/L glucose)and high glucose plus Pioglitazone group (25 mmol/L glucose+100 μmol/L Pioglitazone).The glycerol content of culture medium was determined and taken as the evaluation index of lipolysis;at the same time,Western blot was used to detect the expression of p-Perilipin 1A protein.ResultsAccording to the release amount of glycerol monitored by using the glycerol kit,a more obvious increase was seen in high glucose group than in control group,with statistically significant difference(P<0.01);while,a more obvious decrease of the release amount of glycerol occurred in high glucose plus Pioglitazone group than that in high glucose group,with statistically significant difference (P<0.01);at the same time,the p-Perilipin 1A proteinof high glucose group detected by Western blot was significantly increased in comparison with control group, with statistically significant difference(P<0.01);and the expression of p-Perilipin 1A protein was significantly inhibited in high glucose group in contrast with high glucose plus pioglitazone group,with statistically significant difference (P< 0.01).ConclusionPioglitazone may prevent the up-regulation of p-Perilipin 1A to inhibit glucose-stimulated lipolysis and decrease free fatty acids,thereby improving the insulin resistance.
2017 Vol. 24 (12): 9-11转19 [
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149
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Research advances on the change and regulation of airway micro-ecology in air pollution
ZHANG Yu XIAO Chun-ling
Air pollutants are varieties of solid and liquid particulate matter generated by natural and human activities. The pollutants are easy to absorb the air suspended metal ions,inorganic components,organic ingredients,biological substances,etc..When entering into respiratory tract and adsorbing on the mucous membrane,it causes abnormal changes in the respiratory tract micro-ecology.A reduction in the normal flora of the mouth,such as Streptococcus type A,or the invasion of foreign bacteria,can break the micro ecological balance,causing respiratory infections.The mutual antagonism between the respiratory tract flora should be beneficial to actively explore,and Probiotics should be selected,Probiotics treatment should be initiated.In this paper,the main atmospheric pollutant composition and physicochemical properties, atmospheric pollution and human respiratory disease epidemiology,the respiratory tract microecology change predictiont, the influence of air pollution on the respiratory system,the influence trend of air pollution on respiratory system and the exploration of respiratory tract flora probiotics were reviewed.
2017 Vol. 24 (12): 12-15 [
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150
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Research progress on genetic changes of anaplastic thyroid carcinoma
ZHAO Jia-zheng
As a highly malignant tumor,anaplastic thyroid carcinoma is different from differentiated thyroid cancer, conventionalsurgery,radiotherapy and chemotherapy can achieve poorresults in the treatmentofthyroid undifferentiated carcinoma.With the unceasing research on molecular pathogenesis of anaplastic thyroid carcinoma, many genetic changes are thought to be involved in the development process of anaplastic thyroid carcinoma and to provide a new possibility for molecular targeted treatment of thyroid undifferentiated carcinoma.In this paper,the research progress of the genetic changes related to the pathogenesis of anaplastic thyroid carcinoma is introduced, including RAS/RAF/MAPK/ERK signaling pathway and PI3K/Akt mTOR signaling pathway.
2017 Vol. 24 (12): 16-19 [
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145
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Analysis of serum ferritin level in aplastic anemia patients and nonaplastic anemia with pancytopenia
CHENG Yuan-shan;KUANG Li-ping;LI Hui-jun
ObjectiveTo investigate the level of serum ferritin (SF)and its clinical significance in newly diagnosed aplastic anemia(AA)and other disorders with pancytopenia.MethodsFrom January 2010 to February 2016,340 patients with pancytopenia treated in our hospital were divided into AA group(176 cases),MDS group(56 cases),leukemia group (57 cases),immune disorders group(36 cases)and megaloblastic anemia group(15 cases)based on their diagnoses.Control group including 30 healthy people
received：
health examination in our hospital.Serum ferritin level determined by chemiluminescence as well as complete blood count were tested among the patients and control group.ResultsSF level of newly diagnosed AA patients was(536.32±345.29)μg/L,and it was higher than that of control group and immune disorders group and megaloblastic anemia group,but it was lower than that of leukemia group and MDS group.All the differences are statistically significant(P<0.05).In AA group,the patients that older than 60,male patients and sever aplastic anemia (SAA)patients had a higher level of SF.White blood cell count and platelet count were negatively correlated with SF level(r=-0.171,P<0.05;r=-0.156,P<0.05).Iron overload was diagnosed in 13%newly diagnosed AA patients,male and age>60 years old were the risk factors of iron overload （P<0.05）.ConclusionSF level of newly diagnosed AA patients is higher than healthy people,and it is lower than patients with leukemia and MDS.SF level has a certain clinical significance to the differential diagnosis of the disorders with pancytopenia.
2017 Vol. 24 (12): 20-22 [
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Clinical effect of early surgical stepped treatment to acute biliary pancreatitis
HUANG Rui;HE Ke;XIANG Guo-an;WANG Han-ning;XIAO Jin-feng;CHEN Kai-yun;DUAN Xiao-peng;HE Ji-wen
ObjectiveTo investigate the operation treatment opportunity of acute biliary pancreatitis(ABP).MethodsClinical data of 158 cases with ABP hospitalized in our hospital from January 2010 to December 2016 was analyzed retrospectively.The liver function,amylase,lipase,white blood cell and CRP level and so on were observed on admission, on the first day after endoscopic treatment and the third day after LC treatment.The patient′s disease condition and postoperative recovery were evaluated.ResultsAfter early surgical treatment,there was no serious postoperative complications occurred,the recovery time was significantly shorter.The indexes of liver function and so on were significantly decreased after ERCP was removed (P＜0.05).ConclusionThe clinical efficacy of early surgical stepped care to acute biliary is significant,and it is a safe and effective treatment method.It is worthy of clinical promotion and application.
2017 Vol. 24 (12): 23-25 [
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Analysis of Megadose Meropenem combined with Sulbactam treating pneumonia of multidrug resistant Acinetobacter Bauman
CHEN Jia-wei
ObjectiveTo explore the effect of Megadose Meropenem combined with Sulbactam treating pneumonia of multidrug resistant Acinetobacter Bauman.MethodsThe clinical data of 65 patients with pneumonia of multidrug resistant Acinetobacter Bauman treated in our hospital from June 2011 to August 2016 were selected to analyze.They were divided into two groups according to different therapeutic measures.In the control group(n=30),patients were treated by common dose of Meropenem(1.0 g)combined with Sulbactam,while in the observation group(n=35),high-dose of Meropenem(2.0 g)combined with Sulbactam was adopted.Patients were treated for five days.The plasma indexes(PCT,CRP), white blood cell count,clinical effect,and adverse reaction before and after therapy in the two groups were compared.ResultsThe difference of PCT,CRP,WBC count of the two groups before treatment were not statistically significant(P> 0.05),after treatment,PCT,CRP,WBC count in two groups were lower than that before treatment,and PCT,CRP,WBC count after treatment in the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).ConclusionThe clinical effect of Megadose Meropenem combined with Sulbactam treating pneumonia of multidrug resistant Acinetobacter Bauman caused by drug resistant Acinetobacter Bauman is obvious,and it has no obvious adverse reactions,it is worthy of clinical promotion and application.
2017 Vol. 24 (12): 26-28 [
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176
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Analysis of the risk factors of affecting the prognosis of the paraquat poisoning patients
KE Dao;YAO Wei-xue;ZHOU Ning;SU Geng
ObjectiveTo investigate the associated risk factors affecting the prognosis of patients with paraquat poisoning,and to provide the basis for clinical timely assess the clinical outcome and treatment.Methods86 cases of acute paraquat poisoning were selected in emergency department of our hospital from May 2014 to June 2016.52 cases of the death group,34 cases of the survival group.The relationship of medication dosage,the time from the gastric lavage to poisoning,time of the first blood perfusion,APACHEⅡ score,white blood cell count(WBC),serum creatinine(SCr),blood urea nitrogen(BUN),alanine aminotransferase(ALT),creating kinase isoenzyme(CK-MB)with the prognosis of patients were analyzed,the multivariate stepwise Logistic regression analysis was adopted to define the associated risk factors affecting the prognosis of patients with paraquat poisoning,and ROC curve was used to evaluate the value of risk factors in the prognosis of patients.ResultsThere was significant difference in the medication dosage,time of gastric lavage, WBC count and the level of SCr,BUN,ALT,CK-MB between the two groups(P＜0.05).Logistic regression analysis showed that the dosage of medication and APACHEⅡscore had a greater impact on the prognosis of patients,the higher of APACHEⅡscore,the higher the mortality rate.APACHEⅡscore at different time points had significant difference in the mortality assessment of patients(P＜0.05).The area under the curve with the dose of medication,APACHEⅡ score and the joint evaluation was 93.4%,94.5%and 96.7%,respectively.ConclusionThe dose of medication,APACHEⅡ score can be used as evaluation index of the prognosis of patients with paraquat poisoning and disease severity,the combination of the two indexes is more significant for evaluating prognosis.
2017 Vol. 24 (12): 29-31转46 [
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141
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Characteristics of ambulatory blood pressure monitoring in patients with hypertension and its relationship with stroke
HUANG Yong-hui
ObjectiveTo investigate the characteristics of ambulatory blood pressure monitoring in patients with hypertension and its relationship with stroke.Methods248 patients with hypertension combined with cerebral stroke treated in our hospital from March 2012 to December 2014 were recruited as the cerebral stroke group,and 173 hypertensive patients without cerebral stroke were selected as the control group.The ambulatory blood pressure monitoring was used in both groups to record the average blood pressure of 24 h,pulse pressure(PP)and so on.ResultsIn the cerebral stroke group,average systolic blood pressure(SBP)of 24 h was(142.47±13.24)mmHg,and PP was(67.10±10.13)mmHg,which were significantly higher than the control group[(131.08±14.16)mmHg and(58.34±9.18)mmHg](P<0.05).Meandiastolic blood pressure(DBP)of 24 h was(76.14±9.47)mmHg in the cerebral stroke group,and was(75.98±9.13)mmHg in the control group,there were no significantly difference between both groups (P>0.05).The circadian SBP respectively were (149.54±10.64)mmHg and(140.24±11.54)mmHg in cerebral stroke group,which were remarkblely higher than those of the control group (138.87±9.86)mmHg and(129.57±10.61)mmHg(P＜0.05).DBP at night in cerebral stroke group was(76.04±10.08)mmHg,which was significantly higher than the control group(73.45±9.56)mmHg(P<0.05).The SBP and DBP rhythms were respectively(4.24±0.94)%and(5.53±1.21)%in the cerebral stroke group,which were significantly lower than the control group(9.73±1.32)%and(9.07±1.27)%(P<0.05).ConclusionAverage SBP,PP,circadian SBP and blood pressure circadian rhythm may be relevant to the occurrence of cerebral stroke.Effective control of blood pressure,particularly SBP,may have significant value to reduce the incidence of cerebral stroke.
2017 Vol. 24 (12): 32-34 [
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Influence of occupational therapy on the cognitive function and daily living ability of patients with acute cerebral infarction
LYU Xing;WANG Yu-long
ObjectiveTo discuss the influence of occupational therapy on the cognitive function and daily living ability of patients with acute cerebral infarction.Methods106 patients with acute cerebral infarction treated in our hospital from April 2015 to January 2017 were selected as study objects.All patients were divided into the two groups.The control group was given general rehabilitation training,while the observation group was given occupational therapy on the basis of the control group according to different intervention method.The cognitive function and daily living ability score of patients between the two groups were compared.ResultsThe cognitive function and daily living ability performance in the observation group was better than that in the control group (P<0.05).ConclusionFor patients with acute cerebral infarction,in addition to routine rehabilitation training,occupational therapy added can obviously improve the cognitive function and daily living ability of patientss to ensure that patients get a significant disease recovery effect.
2017 Vol. 24 (12): 35-37 [
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The clinical effect of biofeedback combined with mirror therapy for upper limb dysfunction after stroke
XU Dong-mei FENG Zhen
ObjectiveTo evaluate the clinical efficacy of biofeedback combined with mirror therapy in upper limb dysfunction after stroke.MethodsA total of 110 patients with stroke treated in our hospital from January 2014 and January 2016 were selected and randomly divided into observation group and control group according to the number random grouping method,and there were 55 patients in each group.The control group was treated with neurological medication and rehabilitation training,while the observation group was treated with biofeedback combined with mirror therapy.Efficacy was compared between the two groups.ResultsBefore treatment,FMA and Barthel index in two groups showed no significant differences(P＞0.05).After treatment,FMA and Barthel index were obviously improved,moreover,FMA and Barthel index in the observation group were apparently superior to the control group,and there was a statistical differences(P<0.05). Before treatment,iEMG of the deltoids,triceps and forearm extensors presented no significant differences between two groups(P＞0.05).After treatment,iEMG of the deltoids,triceps and forearm extensors was improved markedly,additionally, iEMG of the deltoids,triceps and forearm extensors in the observation group was apparently superior to the control group,and there was a statistical difference(P<0.05).ConclusionBiofeedback combined with mirror therapy in the treatment of upper limb dysfunction after stroke presents good efficacy,and has a promoting effect in the improvement of upper limb function in stroke patients with hemiplegia.Therefore,it is worthy of clinical promotion and application.
2017 Vol. 24 (12): 38-40 [
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Short term effect of minimally invasive puncture treating hypertensive basal ganglia hemorrhage under CT
FANG Ming
ObjectiveTo investigate the short-term effect of minimally invasive puncture treating hypertensive basal ganglia hemorrhage under CT.Methods84 patients with hypertensive basal ganglia hemorrhage treated in our hospital from September 2014 to September 2016 were selected and randomly divided into control group and treatment group by a random digital table,with 42 cases in each group.The control group was treated with routine craniotomy hematoma removal,while the treatment group was treated with minimally invasive puncture under CT.The operation time,recovery time,total hospital stay,total effective rates,degrees of improvement of cerebral nerve defect scores before and after operation,adverse reactions were compared between the two groups.ResultsThe operation time,recovery time,total hospital stay in the treatment group were shorter than those in the control group,with significant differences(P＜0.05).The total effective rate of operation in the treatment group was up to 88.1%,which was higher than that of 61.9%in the control group with a significant difference(P＜0.05).The degree of improvement of cerebral nerve defect scores before and after operation in the treatment was higher than that in the control group with a significant difference(P＜0.05).The incidence rate of adverse reactions of the treatment group(4.8%)during the operation was lower than that in the control group(23.8%), with a significant difference (P＜0.05).ConclusionMinimally invasive puncture treating hypertensive basal ganglia hemorrhage under CT can reduce the operation trauma,accelerate the recovery and reduce the adverse reactions.
2017 Vol. 24 (12): 41-43 [
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143
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Clinical effect of transabdominal laparoscope in the treatment of upper ureteral calculi
YANG Ting-guang
ObjectiveTo investigate the clinical effect of transabdominal laparoscope in the treatment of upper ureteral calculi.Methods120 patients who diagnosed as upper ureteral calculi in our hospital from January to October 2016 were selected and divided into the observation group and the control group according to random number table methods, and each group was 60 cases.The control group was used ureteroscopic laser lithotripsy,and the observation group was used laparoscopic assisted ureterolithotomy.The operative recovery,complications and stone removal were compared between the two groups.ResultsThe bed stay time,the operation time,and hospital stay in the observation group was longer than that in the control group,bleeding volume in the observation group was more than that in the control group,with significant difference (P＜0.05).The incidence rate of complications in the observation group was 5.00%,which was significantly lower than that of the control group(16.67%),with significant difference(P＜0.05).The stone clearance rate of the observation group was 100%,which was higher than that of the control group (95%),with significant difference (P＜0.05).ConclusionUsing laparoscopic assisted ureterolithotomy in the treatment of upper ureteral calculi can effectively remove the patients′stone and reduce the incidence rate of complications.However,this method has the disadvantages of long time and large amount of bleeding in the operation.
2017 Vol. 24 (12): 44-46 [
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Effect of hemodialysis combined with hemoperfusion on micro inflammatory factor and calcium phosphorus metabolism in long-term hemodialysis patients
FANG Hai-ming;XU Wei-hua;ZHUANG Jin-na
ObjectiveTo investigate the effect of of hemodialysis combined with hemoperfusion on micro inflammatory factor and calcium phosphorus metabolism in long-term hemodialysis patients.MethodsFrom January 2015 to February 2017,82 cases of long-term hemodialysis patients in our hospital were selected and randomly divided into the control group and the study group,41 cases in each group.The control group was given hemodialysis treatment,the study group was treated with hemodialysis and hemoperfusion combined treatment.The levels of micro inflammatory factors and metabolism of calcium and phosphorus in the two groups were compared.ResultsAfter treatment,the micro inflammatory factors(hs-CRP,Hb,Alb,TC)and the level of calcium and phosphorus metabolism (calcium,phosphorus)in the study group were significantly improved,and which was better than that in the control group,with significant difference(P＜0.05).ConclusionThe combination of hemodialysis and hemoperfusion has a positive effect on the improvement of micro inflammatory factor and calcium and phosphorus in long-term hemodialysis patients,which is worthy of clinical promotion.
2017 Vol. 24 (12): 47-49 [
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Effect comparison of titanium alloy elastic intramedullary nail and open reduction and plate fixation in the treatment of limb long bone fractures of children
LI Xing-wang;QIU De-wei;ZOU Yong;XIAO Tai-yang
ObjectiveTo explore the effect of titanium alloy elastic intramedullary nail and open reduction and plate fixation in the treatment of limb long bone fracture of children.Methods36 children with limb long bone fractures from January 2014 to August 2015 in our hospital were selected as the subjects.All the subjects were divided into the control group and the observation group according to the order of admission and random number table method,18 cases in each group.The control group was treated with open reduction and plate fixation,the observation group was treated with titanium alloy elastic intramedullary nail,and the therapeutic effect of the two groups was observed.ResultsThe operative time,intraoperative blood loss and fracture healing time in the observation group were(67.8±2.4)min,(62.4±10.1)ml and (55.7±2.6)d,respectively,which were significantly better than those in the control group(98.5±3.3)min(133.7±9.5)ml, (80.5±3.7)d,the results were significantly different(P＜0.05).The incidence rate of complications and the excellent and good rate of fracture healing were 5.6%and 94.4%,respectively,which were significantly better than those in the control group,with significant difference(P＜0.05).ConclusionThe effect of titanium alloy elastic intramedullary nail in the treatment of limb long bone fracture of children is better than that of open reduction plate.It has the advantages of small intraoperative trauma,quick recovery and less complication,which is worthy of clinical promotion.
2017 Vol. 24 (12): 50-52 [
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Clinical effect of percutaneous endoscopic discectomy in the treatment of lumbar disc herniation
OUYANG Shao-ming;RAO Fang-ping;LIU Hui
ObjectiveTo evaluate the efficacy of percutaneous endoscopic discectomy (PTED)in the treatment of lumbar disc herniation(LDH).Methods42 patients with LDH in our hospital from January 2015 to June 2016 were selected and randomly divided into the control group and the observation group,21 cases in each group.The control group was given conventional fenestration discectomy,the observation group was treated with PTED.The therapeutic effects in the two groups were compared.ResultsThe incision length,postoperative bed time,hospital stay in the observation group was shorter than that in the control group,intraoperative bleeding volume in the observation group was less than that in the control group,with significant difference (P＜0.05).The score of VAS and ODI after operation in the observation group was lower than that in the control group,with significant difference(P＜0.05).There was no significant difference between the two groups in the excellent and good rate of Mac Nab (P＞0.05).ConclusionPTED in the treatment of LDH has little trauma,less bleeding,faster postoperative recovery,less complications,and reliable short-term efficacy.
2017 Vol. 24 (12): 53-55 [
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Influence of Tranexamic Acid on recessive blood loss of PFNA in the treatment of intertrochanteric fractures of elderly patients
WU Jian-feng;YE Song-lin;ZHANG Jing
ObjectiveTo investigate the influence of Tranexamic Acid on recessive blood loss of proximal femoral nail anti-rotation(PFNA)in the treatment of intertrochanteric fractures of elderly patients.MethodsFrom June 2011 to July 2016,95 patients with intertrochanteric fractures in our hospital were retrospectively analyzed.After screening,64 patients were selected and the patients were divided into the study group and the control group according to whether the use of tranexamic acid,32 patients in each group.In the study group,PFNA method was used to fix the fracture site,and before skin incision 10 min,mixture of Tranexamic Acid 1 g with 250 ml saline intravenous infusion were given.The control group was given the same surgical treatment at the same time,and before skin incision 10 min,250 ml saline intravenous infusion were given.The total blood loss,blood volume,dominant blood loss and recessive blood loss were compared between the two groups after 5 d.And 15 d after surgery,patients of the two groups were given routine examination to confirm whether the lower limb venous thrombosis.ResultsThe total blood loss,blood volume and recessive blood loss in the study group was lower than that in the control group,with significant difference(P＜0.05).There was no significant difference between the two groups in the dominant blood loss(P＞0.05).There were no venous thrombosis in the study group,and 4 cases of myenteric vein thrombosis occurred in the control group,but no thrombosis occurred in other parts,and the incidence rate of thrombosis was 12.5%.There was significant difference between the two groups in the incidence rate of thrombosis(P＜0.05).ConclusionTranexamic Acid has a significant decreased effect on the treatment of intertrochanteric fractures with PFNA in elderly patients,and does not cause thrombosis in patients with intertrochanteric fractures.
2017 Vol. 24 (12): 56-58 [
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Clinical effect analysis of improved Stoppa approach in the treatment of pelvic fracture
CHEN Jin;MA Jun-chang;SONG Zhi-hui;CHEN Si;YUAN Jian-bing
ObjectiveTo explore the clinical effect of improved Stoppa approach in the treatment of pelvic fracture.Methods60 patients with pelvic fractures from May 2014 to December 2016 admitted in our hospital were selected as research objects.They were randomly divided into group A and group B,30 cases in each group.In group A,iliac groin approach was used,while in group B,improved Stoppa approach was applied.The relevant surgical indexes and the incidence rate of postoperative complications in the two groups were compared.ResultsThe operation time,hospitalization time,incision length in group B was shorter than that in group A,and the amount of intraoperative bleeding in group B was less than that in group A,with significant difference (P＜0.05).The incidence rate of complication in group B was 3.33%,which was lower than 36.67%in group A,with significant difference (P＜0.05).ConclusionImproved Stoppa approach is effective in the treatment of pelvic fracture and it is worthy of clinical promotion and application.
2017 Vol. 24 (12): 59-60转63 [
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Effect of total hip arthroplasty and hemiarthroplasty in the treatment of senile femoral neck fractures
CHEN Ming;ZHENG Min-qing;WANG Xin-liang;GAO Xing-hua;CHEN Lin
ObjectiveTo analyze the clinical effect of total hip arthroplasty(THA)and hemiarthroplasty(HA)in the treatment of senile femoral neck fractures.Methods240 patients with senile femoral neck fractures in our hospital from January to December in 2016 were selected as research objects.According to the different treatment methods,they were divided into the THA group and the HA group,120 cases in each group.The clinical effect were compared between the two groups.ResultsThe operation time of the THA group was longer than that of the HA group,and the blood loss of the THA group was higher than that of the HA group,with significant difference (P＜0.05).There was no significant difference in hospitalization time between the two groups(P＞0.05).The degree of pain in the THA group was better than that in the HA group,with significant difference (P＜0.05).The incidence rate of complication in the THA group was lower than that in the HA group,with significant difference (P＜0.05).ConclusionBoth of two treatment methods of THA and HA have better clinical effect and its application should be based on the specific conditions of patients.THA should be applied to young patients or patients who have better physical condition and frequent post-operative activities.
2017 Vol. 24 (12): 61-63 [
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The clinical comparison analysis of locking intramedullary pin system and locking plate treating elderly proximal humerus fracture
YAN Li-jun;HUANG Zhu
ObjectiveTo compare the clinical effect of locking intramedullary pin system and locking plate treating elderly proximal humerus fracture.MethodsClinical data of 48 elderly patients with proximal humerus fracture in Integrated Chinese and Western Medicine Hospital from February 2014 to February 2016 were analyzed,and they were divided into two groups by different treatment methods:locking intramedullary pin system group (24 cases)and locking plate group (24 cases).The operation correlation index,Neer score after operation,postoperative complications between two groups were observed.ResultsThe incision length,intraoperatve blood soss,operation time,healing time of locking plate group were higher than those of locking intramedullary pin system group,and the differences were statistical significance (P<0.05).There was no statistical difference in score of pain,after operation,myodynamia,daily activities,range of joint motion,total score between two groups(P>0.05).There was no statistical difference in the internal fixation loosening or breakage,articular dyskinesia or pain,nonunion or delayed union rate between two groups(P>0.05).ConclusionLocking intramedullary pin system treating elderly proximal humerus fracture and its injury is little,recovery is quick.It is worthy of clinical promotion and application.
2017 Vol. 24 (12): 64-66 [
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Impact of Valproic Acid on drug resistance of HL-60 cell
HU Jian-feng;YIN Song-mei;XIE Shuang-feng;NIE Da-nian;LI Yi-qing
ObjectiveTo explore the impact of Valproic Acid(VPA)on drug resistance of HL-60 cells（HL-60/HT）resistant harringtonine.MethodsHL-60/HT cell strain was established by incremental pressure culture and divided into 3 groups:Ara-C group,VPA group and VPA+Ara-C group.MTT method was used to determine the change of proliferation of sensitive cells and drug resistant cells after using drug.The change of VPA resistance in HL-60/HT cells was determinated simultaneously.The cell cycle of seneitive HL-60 cells and HL-60/HT cells were detected by flow cytometry.ResultsVPA in combination with Ara-C can obviously inhibit the growth of HL-60 and HL-60/HT cell,and the inhibition rate was higher than that of VPA or Ara-C alone(q=1.37,1.51).ConclusionVPA can inhibit the growth of HL-60 and HL-60/HT cell.It can play a synergistic role with Ara-C and reduce the drug resistance of leukemia cells.
2017 Vol. 24 (12): 67-68转71 [
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Feasibility study of thoracoscopy and laparoscopy esophagectomy combined with two field lymphadenectomy after resection of esophageal carcinoma for middle esophageal carcinoma
LIN Xiao-zhu
ObjectiveTo analyze the feasibility and clinical value of thoracoscopy and laparoscopy esophagectomy combined with two field lymphadenectomy after resection of esophageal carcinoma for middle esophageal carcinoma.Methods76 patients with middle esophageal carcinoma treated in our hospital from February 2014 to August 2016 were chosen and divided into control group and observation group according to the parity of ID number.The control group was treated with open esophagectomy while the observation group was treated with thoracoscopy and laparoscopy esophagectomy combined with two field lymphadenectomy after resection of esophageal carcinoma.The therapeutic effect and postoperative complications between two groups were compared.ResultsAll patients were successfully completed surgery,the operation time[(132.21±18.42)min vs.(160.54±21.35)min],the amount of bleeding[(201.32±52.16)ml vs. (241.35±77.68)ml],the number of lymph node dissection[(26.89±8.95)vs.(21.65±10.84)d],the hospital stay[(8.36±1.24)d vs. (10.92±3.24)d]in the observation group were better than those of the control group (P<0.05).There was a syiatistical difference of incidence rate of pulmonary infection(10.26%vs.20.62%),hoarseness(15.38%vs.8.11%),and arrhythmia (2.56%vs.16.22%)between the observation group and the control group(P<0.05).ConclusionThe thoracoscopy and laparoscopyesophagectomy combined with two field lymphadenectomy after resection of esophageal carcinoma is effective and safe for middle esophageal carcinoma,which is better in lymph node dissection,and it has a higher clinical promotion value.
2017 Vol. 24 (12): 69-71 [
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135
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Clinical application of fetal foot traction in head presentation dystocia and changed to cesarean section
BU Yun-yun;WU Xiang-rong
ObjectiveTo explore the clinical application value of fetal foot traction in head presentation dystocia and changed to cesarean section.MethodsFrom May 2015 to May 2016,65 maternal who with cephalic dystocia but uterine orifice nearly all open or fully open and delivered in our hospital were selected as study the objects,and they were divided into group A and group B by using random number table.33 patients in group A delivered the fetus by the assistant on the top of the head of the vagina,and the fetal foot traction was carried in 32 maternal of the group B during the operation.The incidence of maternal and fetal complications between the two groups were compared.ResultsThe operation effect in group B was obvious better than group A.The complications of asphyxia neonatorum,intracranial hemorrhage, laceration of uterus,postoperative infection,late postoperative hemorrhage in group B were obvious lower than those in group A,and the difference was significant(P<0.05).ConclusionFetal foot traction in head presentation dystocia and changed to cesarean section can improve the operation effect,reduce the incidence of adverse pregnancy outcomes and postoperative complications,ensure the safety of newborns and mothers and worthy of popularization and application.
2017 Vol. 24 (12): 72-74 [
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130
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Clinical observation on therapeutic effect of neonatal pneumonia by humidified high flow nasal cannula
GUO Wei-zhong;LI Bo;ZENG Zhen-hua;CAO Xiao-yan
ObjectiveTo investigate the effect of heated humidified high flow nasal cannula (HHFNC)on the treatment of neonatal pneumonia.Methods60 children with neonatal pneumonia hospitalized in Paediatrics of the Fourth People′s Hospital of Nanhai District from December 2015 to November 2016 were selected,and they were randomly divided into two groups which had 30 cases in each group.Both two groups were given routine nursing treatment,children in the control group were given nasal continuous positive airway pressure(nCPAP)treatment,which in the observation group were given HHFNC therapy.and then,the results of arterial blood gas analysis,the changes of clinical symptoms and complications were observed in both two groups after 24 h treatment.ResultsAfter 24 h treatment,the differences of the results of PaO2,PaCO2from blood gas analysis of the children in the both two groups between before and after treatment,the difference was statistically significant(P<0.05).The total effective rate of the observation group and the control group had no significantly differences(P>0.05);the use of sedatives and the incidence of complications had a significantly difference between the two groups(P<0.05).ConclusionHHFNC is a safe and effective respiratory support model for the treatment of neonatal pneumonia.
2017 Vol. 24 (12): 75-77转80 [
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139
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Effect of analgesia with intracranial anesthesia on pregnancy outcome and neonatal prognosis in pregnant women during latency
LUO Yue-hua
ObjectiveTo investigate the effect of intrauterine spinal anesthesia on the outcome of pregnancy and the prognosis of neonates.Methods120 cases of pregnant women using anesthesia labor analgesia in our hospital were selected from December 2015 to September 2016,which were evenly divided into control group and observation group randomly,60 cases in each group.Spinal anesthesia block anesthesia was used in the control group when the cervix opened more than 3 cm during the active period,while the cervix opened for 1-2 cm during the latency in the observation group.The first and second birth time,incidence of compliance,cesarean section,neonatal Apgar score and VAS score of patients 5,30,60 min after the labor analgesia were compared between the two groups.ResultsThe labor time, the vaginal delivery rate of the delivery group were significantly bett than those of the control group,the differences were statistically significant(P<0.05);the VAS score of the observation group 5,30,60 min after the labor analgesia were significantly better than those of the control group,the differences were statistically significant(P<0.05).The Apgar score 1 min after birth in the observation group [(8.30±1.24)scores]was significantly higher than that in the control group [(7.08±1.05)scores],the difference was statistically significant(P<0.05).ConclusionIntermittent period of spinal canal anesthesia labor analgesia can quickly relieve maternal pain,improve the outcome of pregnant women and perinatal outcome, worthy of clinical promotion.
2017 Vol. 24 (12): 78-80 [
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109
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81
Effects of three antiviral drugs on the treatment of pregnancy with AIDS
PENG Li-qun
ObjectiveTo explore the clinical effect of three antiviral drugs in the treatment of pregnancy with AIDS.MethodsA total of 120 cases of pregnant women with AIDS were selected from January 2010 to December 2016 in Duanzhou area hospital of Zhaoqing city,they were divided into control group and observation group according to the random number table,each group had 60 cases.The control group was treated with Zidovudine Tablets and Lamivudine Tablets.The observation group was treated with Zidovudine Tablets,Lamivudine Tablets and Nevirapine Tablets.Statisticsand analysis with pregnancy,fetal survival,blocking effect and the occurrence of adverse reactions of the two groupswere compared.ResultsIn this study,the follow-up rate was 100%.There were no significant differences in the mode of delivery and fetal survival between the two groups(P>0.05).The success rate of the observation group (100.00%)was significantly higher than that of the control group (91.67%)(P<0.05).The total incidence of adverse reactions and the incidence of adverse events in the two groups had no significantly different(P>0.05).ConclusionThe combination of Zidovudine Tablets,Lamivudine Tablets,Nevirapine Tablets can effectively reduce the probability of mother to child transmission of AIDS,and has a certain degree of safety.
2017 Vol. 24 (12): 81-83 [
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103
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84
Effect of conventional treatment combined with lung surface active substance in the treatment of premature infant respiratory distress syndrome
CHEN Shao-li;QIAO Ping;WANG Wei-ming;LI Jin-wen
ObjectiveTo study the conventional treatment combined with lung surface active substance in the treatment of premature infant respiratory distress syndrome.MethodsFrom February 2008 to February 2016,100 cases of children with premature respiratory distress syndrome were selected and randomly divided into observation group and the control group,50 cases in each group.Control group was given conventional treatment,and the observation group was given the lung surface active substance on the basis of the control group.The blood gas and oxygenation function index before and after treatment,and time of mechanical ventilation,oxygen therapy after treatment,length of hospital stay and clinical effect of children were compared between the two groups.ResultsAfter treatment,blood gas and oxygenation function index of the observation group were better than those of the control group(P<0.05);the time of mechanical ventilation,oxygen therapy after treatment,length of hospital stay of the observation group were shorter than those of the control group (P<0.05);the treatment effect of observation group was obviously better than that of control group (P<0.05).ConclusionIn treatment of premature infant respiratory distress syndrome,the lung surface active substance has shorten the length of hospital stay,time of oxygen therapy and mechanical ventilation,and has obviously improved the lood gas and oxygenation function,treatment effect is remarkable,it is worthy of further application in clinic.
2017 Vol. 24 (12): 84-86 [
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159
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Clinical observation on acupoint application with Chinese medicine in adjuvant treatment of infantile pneumonia
WU You-ping;LI Nan-de;LIANG Yue-chang
ObjectiveTo investigate the clinical efficacy of acupoint application with Chinese medicine in adjuvant treatment of infantile pneumonia.Methods240 children with pneumonia treated in our hospital from January 2015 to January 2017 were divided into two groups by random number table,and there were 120 cases in each group.Control group was given routine treatment,on this basis the observation group was added acupoint application with Chinese medicine.After one-week continuous treatment,the curative effects and disappearance time of symptoms between two groups were compared.ResultsThe total effective rate of observation group was 95.00%,which was significantly higher than 76.67%of control group (P<0.05).The disappearance time of symptoms and hospital stays of observation group were shorter than those of control group (P<0.05).ConclusionCompared with simple western medicine in treatment of infantile pneumonia,acupoint application with Chinese medicine can significantly increase clinical efficacy,accelerate disease outcome and have no obvious adverse reactions during treatment.It is a safe and efficient treatment method, which is worthy of wide clinical application.
2017 Vol. 24 (12): 87-89 [
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145
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Efficency and safety of Midazolam combined with Fentanyl in sedation and analgesia of critically severe patients with mechanical ventilation
ZHANG Hong-mei;REN Wei-hong;YAO Yu-ling
ObjectiveTo explore the Efficency and safety of Midazolam combined with Fentanyl in sedation and analgesia of critically severe patients with mechanical ventilation.Methods122 cases of severe patients undergoing mechanical ventilation in our hospital from December 2014 to December 2016 were selected and divided into experimental group and control group,with 61cases in each group.The control group was used Midazolam for sedation before intubation.The experimental group was used Fentanyl on the basis of control group.The onset time,wake up time,the degree of patient distress and 24 h after mechanical ventilation,the blood pressure,heart rate,RP,SpO2,SpO2/FiO2of patients and were compared between two groups.ResultsThe onset time and wake up time[(49.3±8.7)s,(20.2±6.2)min]in experimental group were shorter than those in control group [(85.6±12.7)s,(39.2±8.9)min],the BPS score of experimental group [(2.4±1.0)points]was lower than that in control group[(5.2±2.4)points],the levels of heart rate and PR[(75.3±6.6),(14.2± 3.5)times/min]of patient in experimental group were lower than those in control group[(84.1±7.8),(18.8±4.1)times/min], the SpO2,SpO2/FiO2in experimental group[(97.1±2.5)%,(256.4±25.6)mmHg]were higher than those in control group [(92.2±3.3)%,(209.8±30.8)mmHg],the total incidence of adverse reaction in experimental group(21.31%)was lower than that in control group(61.85%).All the differences were statistically significant(P<0.05).ConclusionMidazolam combined with Fentanyl in mechanical ventilation sedation and analgesia of critically ill patients with advantages of short onset time,fast wake up,significantly reducing the pain of patients,and has less affect on heart rate and respiratory rate.It is worthy to popularize.
2017 Vol. 24 (12): 90-92 [
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170
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Efficency comparison of Remifentanil analgesia and Sufentani combined with Ropivacaine analgesia in labor
ZHANG Xiao-hua;LI Xi-rong
ObjectiveTo compare the safety and feasibility of Remifentanil parturient-controlled intravenous analgesia (PCIA)and Sufentani combined Ropivacaine parturient-controlled epidural analgesia(PCEA)in labor.MethodsFrom January 2013 to December 2014,246 cases of pregnant women who were full-term pregnancy suitable for vaginal trial delivery and head position single pregnancy healthy primipara,ASAⅠ-Ⅱ,were
received：
labor analgesia.They were randomly divided into PCIA and PCEA group,with 123 cases in each group.When the uterus cervix opened to 4 cm,PCIA group were given intravenous Remifentanil,the loading dose was 0.02 μg/ml,the maintenance dose was 0.04 μg/(kg·min), PCA dose was 0.4 μg/kg and the locking time of analgesic pump was 3 min.While PCEA group were given Sufentanil 0.4 μg/ml+0.1%Ropivacaine by epidural catheter,the loading dose and maintenance dose were 5-6 ml/h,the PCA dose was 6 ml,and the locking time of analgesic pump was 30 min.Analgesia was stopped when uterine orifice fully open and continued when the perineum incision was sutured.Visual analogue scale(VAS)score before analgesia(T0),1,2,3 h(T1,T2, T3)after analgesia of two groups were observed and the labor time,delivery mode,neonatal Apgar score andadverse reactions of two groups were recorded.ResultsVAS score of PCEA group was obviously lower than PCIA group at T1,T2,T3,(P<0.05).there were no statistically significant difference between two groups in eutocous rate,1abor process, the period of first,second,and third stage of labor,forceps delivery rate,cesarean section rate and the rate of using of oxytocin,neonatal Apgar score,and incidences of vomiting and pruritus(P>0.05);there had a significantly higher incidence of dizziness in PCIA group than in PCEA group,but the incidence of lower limb numbness in PCIA group was significantly lower than in PCEA group,the difference was statistically significant(P<0.05).ConclusionRemifentanil PCIA is not so effective as Sufentanil combined Ropivacaine PCEA,but it is easy operation,less trauma,quick onset.So Remifentanil PCIA can be used under the precondition of ensuring to monitor the maternal and fetal when the maternal especially has contraindication of intraspinal block,fear of intra-spinal canal puncture and anesthesia position incompatibility．
2017 Vol. 24 (12): 93-96 [
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Effect of Propofol combined with Sevoflurane on serum cortisol levels during perioperative period in patients undergoing radical gastrectomy
LIU Jiang-mei LIU Jiang-ping
ObjectiveTo investigate the effect of Propofol combined with Sevoflurane on serum cortisol in perioperative period.Methods160 patients with gastric cancer and radical gastrectomy in our hospital from December 2015 to December were selected,randomly divided into two groups,the control group(80 cases)and the observation group(80 cases), The control group were given etomidate anesthesia,the observation group were given Propofol and Sevoflurane compound anesthesia,the effects of the two groups were compared.ResultsBefore and after anesthesia,the level of serum cortisol in the two groups were normal,and the serum cortisol levels in the control group was increased first and then decreased，while the observation group was increase first and then decreased.The serum cortisol levels at 1 h and 1 d after anesthesia in the observation groups were higher than those in the control group,and the differences were statistically significant(P<0.05);the blood pressure,heart rate and blood oxygen saturation of the observation group were significantly better than those of the control group,and the differences were statistically significant(P<0.05).ConclusionRadical surgery with Propofol and Sevoflurane combined anesthesia can make patients with perioperative serum cortisol content is significantly increased,and vital signs of patients is more stable,it can be used as radical cancer radical surgery preferred narcotic drugs.
2017 Vol. 24 (12): 97-99 [
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140
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Clinical application of multimodol analggesia in conscions anesthesia during imtervertebral foramen surgery
CHEN Chang-liang;CHEN Yuan-sheng
ObjectiveTo study the efficacy and safety of multimodal analgesia in comscious anesthesia durimg intervertebral foramen surgery.Methods92 patients
received：
transforaminal endoscopic surgery in our hospital from June 2015 to October 2016 were selected and divided into two groups according to the sequence to operating room,with 46 cases in each group.Patients in group A were given multimodal analgesia,while patients in group B were given routine local anesthesia.The levels of MAP,HR,pain degree,time of chills reaction time and operation,respiratory depression,postoperative adverse reactions of patients were compared between two group.ResultsThe levels of MAP,HR,pain degree,time of chills reaction time and operation,respiratory depression,postoperative adverse reactions of patients in group A were better than those in group B,and the differences were statistically significant(P<0.05).There was no adverse reaction in both groups A and B.ConclusionReducing the operative pain of multimodal analgesia and analgesia in foraminal mirror awake in the operation,improving safety and comfort.
2017 Vol. 24 (12): 100-102 [
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109
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Diagnostic value of transvaginal three-dimensional ultrasound combining with blood human chorionic gonadotropin in endometrial carcinoma
ZHENG Xiao-hong;CHEN Feng-chun;ZHU Li-min;LUO Li-fang;DENG Jin-yao;ZHU Yan-fang;QUAN Xiao-guang
ObjectiveTo investigate the diagnostic value of transvaginal three-dimensional ultrasonography combining with human chorionic gonadotropin(HCG)in patients with endometrial carcinoma.MethodsFrom August 2015 to October 2016,90 patients with vaginal bleeding for more than two years after postmenopausal period were collected in our hospital and the Fourth People′s Hospital of Nanhai District and divided into the endometrial hyperplasia group(n=64) and the endometrial carcinoma group(n=26)according to histopathological examinations.The endometrial thickness and volume were measured by transvaginal three-dimensional ultrasonography in both groups.The level of serum β-HCG was determined by chemilumineseent immunoassay (CLIA).The endometrial thickness and volume as well as serum β-HCG level were compared in the two groups.Besides,correct diagnostic rate,the rate of missed diagnosis,misdiagnosis rate,sensitivity,specificity,positive predictive value,negative predictive value,and accuracy on benign and malignant diseases of serum HCG,three-dimensional ultrasonography and three-dimensional ultrasonography combining with serum HCG were compared.ResultsIn the endometrial carcinoma group,endometrial thickness,volume was larger than that in the endometrial hyperplasia group,and serum β-HGC level was higher than that in the endometrial hyperplasia group, with significant difference (P＜0.05).The correct diagnostic rate was higher and the misdiagnosis rate and rate of missed diagnosis were both lower by three-dimensional ultrasonography combining with serum HCG.In comparison with threedimensional ultrasonography combining with serumHCG,sensitivity,specificity,positive predictive value,negative predictive value,and accuracy by serum HCG or three-dimensional ultrasonography only were all lower,which was displayed statisticaldifference(P＜0.05).ConclusionTransvaginal three-dimensional ultrasonography combining with serum HCG can improve the diagnosis rate of early-stage of endometrial carcinoma with higher sensitivity and specificity,which provides the basis for early diagnosis and treatment by physicians,so that more patients will get early treatment.It greatly improve patients′prognosis and is of great significance.
2017 Vol. 24 (12): 103-106 [
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115
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Application study of Multi slice spiral CT 3D imaging in the diagnosis of styloid process syndrome
FAN De-hong;LIU Han-dong;LIAO Ling-mei;LING Yong-wei
ObjectiveTo analyze the clinical value of Multi slice spiral CT 3D imaging in the diagnosis of styloid process syndrome.Methods106 styloid process syndrome patients from March 2016 to January 2017 of our hospital were selected and divided into the observation group and the control group according to random number table methods,53 cases in each group.The observation group was used Multi slice spiral CT 3D imaging and the control group was used CT imaging.The detection results between the two groups was compared.ResultsThe detection rate of styloid process in the observation group was higher than that in the control group,with significant difference (P＜0.05).The clinical coincidence rate in the observation group was higher than that in the control group,the error value of styloid process length, the error value of inclination angle,the error value of anteversion angle in the observation group was less than that in the control group,with significant difference (P＜0.05).ConclusionUsing Multi slice spiral CT 3D imaging can improve the check accuracy of styloid process syndrome effectively,and should be popularized in clinical use.
2017 Vol. 24 (12): 107-109 [
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135
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Comparison of application value of X-ray and CT plain scan combined with three-dimensional reconstruction in the diagnosis of tibial plateau fractures
TAN Guo-guang;OU Yan-zhuang;HE Rui-cheng
ObjectiveTo compare the value of X-ray and CT plain scan combined with three-dimensional reconstruction in the diagnosis of tibial plateau fractures.Methods98 patients with tibial fractures in our hospital from November 2013 to November 2016 were enrolled in this study.All patients underwent X-ray and CT plain scan and three-dimensional reconstruction.According to the results of the examination,tibial fractures was diagnosed by the doctors.The number of diagnosed and misdiagnosed patients were calculated.The diagnosis rate and misdiagnosis rate were used as the observation indexes to compare the effect of different examination methods to judge the clinical application value.ResultsThe number of confirmed X-ray examination was 67 cases,the diagnosis rate was 68.37%.The number of suspected fractures was 7 cases,accounting for 7.14%.The number of misdiagnosed patients was 24 cases,the misdiagnosis rate was 24.49%.The number of diagnosed patients by CT scan and 3D reconstruction was 82 cases,accounting for 83.67%. The number of suspected fractures was 6 cases,accounting for 6.12%.After three-dimensional CT reconstruction,the number of misdiagnosed patients was 10 cases,and the misdiagnosis rate was 10.20%.There was significant difference in the misdiagnosis rate and the diagnosis rate between the two geoups(P＜0.05).ConclusionCT plain scan combined with three-dimensional reconstruction has important positive significance for the diagnosis of suspicious fractures,and has a higher clinical application value.However,X-ray plays a key role in showing the morphology and appearance of fractures,and the results of the two methods is better.
2017 Vol. 24 (12): 110-112 [
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127
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Effect analysis of ultrasonic elastography and conventional ultrasound in the diagnosis of benign/malignant thyroid nodules
PENG Yi-ping
ObjectiveTo analyze the effect of ultrasonic elastography and conventional ultrasound in the diagnosis of benign/malignant thyroid nodules.MethodsFrom October 2013 to October 2016,imaging data of ultrasonic elastography and conventional ultrasound from 93 patients(126 nodules)with space-occupying lesion of thyroids testified by pathology in our hospital were retrospectively analyzed.Set outcome of histopathology by surgery as gold standard,the accuracy of the two methods diagnosing the benign/malignant thyroid nodules.ResultsAmong 126 thyroid nodules,benign ones were 108 cases(85.71%),and malignant ones were 18(14.29%).The sensitivity,specificity and accuracy of ultrasonic elastography diagnosis were 82.41%,77.78%and 81.75%respectively,which was higher than that in the conventional ultrasound accounting for 74.07%,66.67%and 79.36%in turn (P＜0.05).The sensitivity,specificity and accuracy of ultrasonic elastography combined with conventional ultrasound were 93.52%,83.33%,92.06%respectively,which was superior to either of them (P＜0.05).ConclusionIn the differential diagnosis of benign/malignant thyroid nodules,ultrasonic elastography is better than that by conventional ultrasound.The combination can effectively improve the diagnostic accordance rate.
2017 Vol. 24 (12): 113-115转121 [
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126
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Clinical diagnostic value analysis of cardiac color Doppler ultrasonography in hypertension-induced left ventricle hypertrophy patients with left heart failure
LAN Rong-qing
ObjectiveTo analyze the clinical diagnostic value of cardiac color Doppler ultrasonography in hypertensioninduced left ventricle hypertrophy patients with left heart failure.MethodsFrom July 2014 to July 2016,58 hypertension-induced left ventricle hypertrophy patients with left heart failure treated in our hospital were selected as the observation group.Another group of 58 healthy people visiting our hospital for physical examinations were selected as the control group during the same period.Both groups were provided with cardiac color Doppler ultrasonography.Indexes of diastolic blood pressure (DBP),systolic blood pressure (SBP),left ventricular weight(LVM),left ventricular mass index (LVMI),left ventricular fractional shortening (LVFS),left ventricular end-diastolic diameter (LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction (LVEF),left atrial diameter(LAD),maximal blood flow velocity of opening of mitral valve at early diastolic stage (E)/maximal speed of movement of mitral valve at early diastolic stage (A)were compared between the two groups.ResultsIn the observation group,the SDP,SBP,and LVEDD were all much higher in comparison with those in the control group,with statistical differences(P＜0.05).The indexes of LVM, LVMI,LVEF and LVFS were significantly higher in the observation group compared with those in the control group,with statistical differences(P＜0.05).In the observation group,the peak value A was significantly higher than that in the control group,while the peak value E and E/A ratio were greatly lower than those in the control group,with statistical differences(P＜0.05).In patients with gradeⅢcardiac function,the indexes of LAD,LVEDD and E/A were significantly higher than those in gradeⅡ,while LVEF was much lower than that of gradeⅡ,with statistical differences(P＜0.05).Conclusion Cardiac color Doppler ultrasound can dynamically display the structure of cardiac cavity,heart beat and blood flow as well as accurately evaluate the cardiac function at advantages of no trauma and repeatable performance,which can be considered as a basis for early judgment for patients′disease condition.
2017 Vol. 24 (12): 116-118转124 [
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130
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Application value of abdominal ultrasound and vaginal ultrasonography in the diagnosis of early ectopic pregnancy
XIONG Ke
ObjectiveTo compare the application effect of abdominal ultrasound and vaginal ultrasonography in the early diagnosis of ectopic pregnancy.Methods106 pregnant women who were examined in our hospital from February 2014 to February 2016 were selected and divided into the study group and the control group according to the order of pregnant women.In the control group,pregnant women were diagnosed by abdominal ultrasound.The pregnant women in the study group were diagnosed by vaginal ultrasonography.The diagnostic accuracy between the two groups was compared.ResultsThe diagnostic accuracy of the study group was 92.45%,which was higher than 69.81%of the control group,with significant difference (P＜0.05).ConclusionThe appllication of vaginal ultrasonography in the ecctopic prenancy,the effect of early diagnosis is significant,and the application value is significant,which is worthy of clinical promotion and application.
2017 Vol. 24 (12): 119-121 [
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128
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Combined application value of CT and MRI in the diagnosis of intrahepatic cholangiocarcinoma
ZENG Yan-hui;SHUAI Guo-qiang
ObjectiveTo explore the combined application value of CT and MRI in the diagnosis of intrahepatic cholangiocarcinoma.Methods30 patients with intrahepatic cholangiocarcinoma in our hospital from March 2014 to March 2016 were selected as the research object,CT plain scan and enhanced scan,MRI examination was given respectively.The sensitivity,specificity and accuracy of CT,MRI and combined diagnosis were statistically analyzed.ResultsIn pathological diagnosis,30 cases were diagnosed intrahepatic cholangiocarcinoma,and 4 cases were non-intrahepatic cholangiocarcinoma.The sensitivity of CT was 100.0%,the specificity of CT was 50.0%,and the accuracy of CT was 86.7%.The sensitivity of MRI was 100.0%,the specificity of MRI was 100.0%,and the accuracy of MRI was 100.0%. The diagnostic accuracy of combined detection was 100.0%,which was higher than that of CT (86.7%),with significant difference(P＜0.05).ConclusionThe diagnosis of intrahepatic cholangiocarcinoma patients using CT combined with MRI technology has high accuracy,which can rapid accurate understand the development of the lesion of patients,with higher diagnostic value,it is worthy of clinical promotion and application.
2017 Vol. 24 (12): 122-124 [
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Effect of Nerve Growth Factor combined with Flunarizine Hydrochloride in treatment of cerebral hemorrhage
LIN Xiao-ling
ObjectiveTo investigate the effect of Nerve Growth Factor(NGF)combined with Flunarizine Hydrochloride in treatment of cerebral hemorrhage.Methods150 patients with cerebral hemorrhage treated in our hospital from May 2013 to May 2016 were divided into two groups by draw lots,and there were 75 cases in each group.Control group was treated by Flunarizine Hydrochloride,while observation group was treated by NGF combined with Flunarizine Hydrochloride.After treatment,the nerve function and living quality between two groups were compared.ResultsAfter treatment,the neurological function deficit scale of two groups were lower than before treatment(P<0.05),the neurological function deficit scale of observation group was lower than that of control group,and scores of living quality indexes were higher than control group(P<0.05).The score of emotion,hand function,communication skill,memory and thought,social participation and strength of control group were compared with before treatment,there was no statistical difference(P>0.05), and the above scores of observation group were higher than before treatment(P<0.05).ConclusionNGF combined with Flunarizine Hydrochloride for cerebral hemorrhage patients has definite effect,which can improve nerve function of patients and improve their living quality.
2017 Vol. 24 (12): 125-127 [
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Efficacy analysis of Tigecycline combined with Cefoperazone/Sulbactam in the treatment of elderly patients with severe pneumonia caused by Acinetobacter baumannii
ZOU Huai-yu;LIU Li-qiong;XU Yan;HUANG Hui
ObjectiveTo investigate the efficacy of Tigecycline combined with Cefoperazone/Sulbactam in the treatment of elderly patients with severe pneumonia caused by Acinetobacter baumannii.Methods100 elderly patients with pneumonia caused by Acinetobacter baumannii were treated in our hospital from June 2013 to June 2016 were selected and randomly divided into the control group and the observation group,50 cases in each group.The control group was treated with Cefoperazone/Sulbactam treatment,the observation group was treated with Tigecycline combined with Cefoperazone/ Sulbactam.The clinical efficacy of the two groups was compared.ResultsThe improvement time of body temperature, rales,C-reactive protein,white blood cells and chest radiography in the observation group was shorter than that in control group,the offline success rate and total effective rate of the observation group was higher than that of the control group,with significant difference (P＜0.05).The bacterial clearance rate and the reinfection rate in the observation group was better than that in the control group,and the incidence rate of adverse reaction in the observation group was lower than that in the control group,with significant difference (P＜0.05).ConclusionFor the elderly patients with severe pneumonia caused by Acinetobacter baumannii,Tigecycline combined with Cefoperazone/Sulbactam is more effective than simple use of a drug treatment,with relative ideal in safety,it is worthy of clinical application and promotion.
2017 Vol. 24 (12): 128-130转137 [
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Analysis on the effect of recombinant human brain natriuretic peptide in the treatment of acute decompensated severe patients with chronic heart failure
CHEN Jin-long
ObjectiveTo analyze the efficacy of recombinant human brain natriuretic peptide in the treatment of acute decompensated severe patients with chronic heart failure.Methods90 acute decompensated severe patients with chronic heart failure who were treated in our hospital from January 2015 to January 2016 were selected as the study subjects. They were randomly divided into the observation group and the control group,with 45 patients in each group.Patients in the observation group were given intravenous injection of recombinant human brain natriuretic peptide for treatment;patients in the control group were treated with intravenous injection of Milrinone.The total effective rate after treatment, hemodynamic parameters after treatment(myocardial longitudinal SR,CI,SV),and the volume of urine,heart rate,mean arterial pressure,plasma BNP changes,and the improvement of cardiac function(LVEDD,LVEF)were compared between the two groups.ResultsThe total effective rate was 97.77%in the observation group and 84.44%in the control group. The difference compared between the two groups was statistically significant(P<0.05);there was no statistically significant difference in mean arterial pressure and LVEDD after treatment between the two groups(P>0.05);after treatment,the hemo dynamic parameters(myocardial longitudinal SR,CI,SV),urine volume,heart rate,plasma BNP changes and LVEF improve ment in the observation group were better than those in the control group after treatment(P<0.05),and the differences were statistically significant.ConclusionThe application of intravenous injection of recombinant human brain natriuretic peptide in the treatment of acute decompensated severe patients with chronic heart failure can significantly enhance the total effective rate of treatment,improve the clinical symptoms and the cardiac function.It is worthy of clinical promotion and application.
2017 Vol. 24 (12): 131-133 [
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150
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134
Study on the effect of clinical pharmacists′clinical rational drug usage of patients with diabetes and depression
ZHAO Yue-lan
ObjectiveTo explore the effect of clinical pharmacists′in clinical rational drug usage of patients with diabetes and depression.MethodsAltogether 90 cases of patients with type 2 diabetes and depression who were hospitalized in Department of Endocrinology of Jining Municipal Hospital of Traditional Chinese Medicine from September to December 2016 were selected and randomly divided into group A,group B and group C by random number table,with 30 cases in each group.All the three groups were treated with antidiabetic drug (Metformin Hydrochloride Sustained Release Tablets),group A was given Sertraline for antidepressant treatment,group B was given Liver-Smoothing and Depress-Relieving Capsules for antidepressant treatment,group C was given the combination of Sertraline and Liver-Smoothing and Depress-Relieving Capsules for antidepressant treatment in addition,and the schene was maken by clinical pharmacists and clinicist;the course of treatment for three groups was 6 weeks.The glycosylated hemoglobin (HbA1c)was adopted for evaluation of pre-and post-treatment blood glucose level in three groups;the self-rating depression scal(SDS)was used for assessment of the pre-and post-treatment depression in three groups;and the treatment emergent symptom scale(TESS)was used for assessment of pre-and post-treatment drug adverse reactions in three groups;the correlation between HbA1c and depression was analyzed by using Pearson correlation analysis method.ResultsThe pre-treatment HbA1c and SDS scores of three groups were not statistically significant(P>0.05);the posttreatment HbA1c and SDS scores of group C were significantly lower than those of group A and group B(P<0.01);the post-treatment SDS scores of three groups were significantly lower than those before treatment(P<0.01);no statistically significant difference was seen between in post-treatment SDS score;the SDS score of group C was significantly lower than that of group A and group B(P<0.01);there was no adverse reaction was seen in group B,incidence of adverse reac tion of group A was 38.4%,significantly higher than that of group C,there was no adverse reaction was seen in group B(14.7%)(χ2=14.258,P<0.01);the effective rate of group C was 97.4%,significantly higher than that of group A (84.6%) and group B(86.1%)(χ2=9.902,8.350,P<0.01);According to the Pearson correlation analysis,it was shown that HbA1c was positively correlated(r=0.246,P<0.05).ConclusionClinical pharmacists′participation in the medication treatment of patients with diabetes and depression can achieve good clinical results
2017 Vol. 24 (12): 134-137 [
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145
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Clinical effect of three-dimensional traction combined with massage chiropractic techniques in the treatment of lumbar spondylolisthesis
ZHANG Chu-hui;PENG Ling;ZHANG Ai-qin
ObjectiveTo explore the clinical effect of three-dimensional traction combined with massagechiropractic techniques in the treatment of lumbar spondylolisthesis.Methods200 patients with lumbar spondylolisthesis who were admitted into our hospital from April 2015 to April 2016 were selected as study object.They were divided into the observation group and the control group according to the random number table method,and there were 100 cases in each group.The patients in the control group were treated with massage chiropractic techniques,and the patients in the observation group were further given three-dimensional traction on the basis of massage chiropractic techniques.Change of JOA lumbago scale score,clinical efficacy and treatment time,as well as patients′satisfaction degree were compared between the two groups.ResultsAfter treatment,JOA lumbago scale score of the observation group [(20.13±1.68)points] was significantly higher than that of the control group[(18.78±2.24)points](P<0.05).The total effective rate of the observation group(97.0%),which was significantly higher than that of the control group(80.0%),and the treatment time of the observation group[(22.31±2.07)d]was significantly shorter than that of the control group[(34.11±1.92)d](P<0.05). The satisfaction degree of the patients in the observation group was 98.0%,which was significantly higher than that of the control group(76.0%)(P<0.05).ConclusionThree-dimensional traction combined with massage chiropractic techniques in the treatment of lumbar spondylolisthesis has a good clinical effect.The method can effectively reduce the pain of patients,shorten the treatment time,and improve patients′satisfaction degree.
2017 Vol. 24 (12): 138-140 [
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109
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Clinical study of modified Buyang Huanwu Decoction combined with TCM directed medicine penetration instrument in the treatment of cervical insomnia
CHEN Dian-feng;HU Min;LI Hua;KE Xi-wen;ZHANG Yan-chun;ZHANG Wei-juan;LU Fu-er
ObjectiveTo observe the clinical effect of Buyang Huanwu Decoction combined with traditional Chinese medicine (TCM)directed medicine penetration instrument in the treatment of cervical insomnia.MethodsFrom March 2015 to September 2016,60 cervical insomnia patients meeting the inclusion criteria from the Fifth People′s Hospital of Jiujiang City,Jiujiang Traditional Chinese Medicine Hospital,Xianggan Hospital in Jiujiang Development Distrct were recruited.According to a random number table method,they were divided into observation group (n=30)and control group (n=30).In the observation group,patients were provided with modified Buyang Huanwu Decoction for oral administration combined with TCM directed medicine penetration instrument,while in the control group,only modified Buyang Huanwu Decoction for oral administration was used.The total effective rate and the score of Athens insomnia scale after therapy in the two groups were compared.ResultsThe total effective rate of the observation group was 93.33%,and it was higher than that in the control group (76.67%)with a statistical difference (P<0.05).Compared with before treatment,the score of Athens insomnia scale after treatment were both markedly improved with statistical differences (P< 0.05).The improvement of the score of Athens insomnia scale in the observation group was superior to that in the control group,which was displayed a statistical difference (P<0.05).ConclusionModified Buyang Huanwu Decoction combined with TCM directed medicine penetration instrument can obtain a remarkable effect treating cervical insomnia, which is worthy of clinical promotion.
2017 Vol. 24 (12): 141-143转152 [
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Effect of muscle stretch therapy combined with massage acupuncture in the treatment of periarthritis of shoulder
HUANG Kuan-ju;LIU Xin;GUO Zhang-sheng
ObjectiveTo investigate the effect of muscle stretch therapy combined with massage acupuncture in the treatment of periarthritis of shoulder.MethodsFrom February 2013 to October 2014,62 cases with periarthritis of shoulder treated in our hospital were selected.According to the difference of treatment plan,the patients were divided into the control group and the observation group,and there were 31 cases in each group.The control group was treated with massage acupuncture,while the observation group was treated with muscle stretch therapy on the basis of the control group. The clinical efficacy and incidence of adverse reactions were compared between the two groups.ResultsThe improve ment of VAS,ADL score in the observation group was larger than that of the control group(P<0.05).The total effective rate of the observation group was 93.55%,which was significantly higher than that of the control group(P<0.05).The incidence rate of adverse reactions in the observation group was 9.68%,which was significantly lower than that of the control group (P<0.05).ConclusionMuscle stretch therapy combined with massage acupuncture in the treatment of periarthritis of shoulder can not only help to improve the pain and ability of daily life activities in patients，but also can significantly improve the clinical efficacy,reduce the incidence rate of adverse reactions.
2017 Vol. 24 (12): 144-146 [
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128
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The influence ofShuanghuanglian Injection and Shuanghuanglian Lyophilized Power Injection on hemolytic effect in rabbits′red blood cells in vitro
SHANG Shu-yu;HU Xiao-feng;LI Jing;QIN Jun-lian
ObjectiveTo observe the influence of Shuanghuanglian Injection and Shuanghuanglian Lyophilized Power Injection on hemolytic effect in rabbits′red blood cell(RBC)in vitro.MethodsThe blood samples were collected from healthy rabbits by 20 ml,and the red blood cell suspension of 2%was prepared,and it with Shuanghuanglian Injection, Shuanghuanglian Lyophilized Power Injection and Sodium Chloride Injection of 0.9%were co-incubated,and hemolysis test was carried out in vitro,and the absorbance was detected by spectrophotometer.The hemolysis rate of RBC in 3 h was observed.ResultsThe hemolysis rate of Shuanghuanglian Injection with concentration of 0.06,0.12,0.18,0.24,0.3 g/ml was 8.39%,21.34%,40.98%,50.36%,67.68%respectively,and there was a statistical difference between two groups compared with Sodium Chloride Injection of 0.9%(P＜0.05).The hemolysis rate of Shuanghuanglian Lyophilized Power Injection with concentration of 0.06,0.12,0.18,0.24,0.3 g/ml was 2.15%,5.23%,7.31%,9.59%,13.35%respectively,and there was a statistical difference when the concentration was 0.3 g/ml compared with Sodium Chloride Injection of 0.9%(P＜0.05).When the concentration was 0.12,0.18,0.24,0.3 g/ml,there was a statistical difference of hemolysis rate between Shuanghuan glian Injection and Shuanghuanglian Lyophilized Power Injection(P＜0.05).ConclusionThe influence of Shuanghuanglian Lyophilized Power Injection on hemolytic effect is small compared with Shuanghuanglian Injection．
2017 Vol. 24 (12): 147-149 [
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155
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Study of the expression and value of P16,PTEN and CyclinD1 in adnexal differentiation of basal cell carcinoma
RONG Xi-yun
ObjectiveTo comprehensive ly analyze the expression and value of P16,PTEN and CyclinD1 in adnexal differentiation of basal cell carcinoma.MethodsThe clinical data of 33 skin basal cell carcinoma patients from March 2015 to May 2016 treated in our hospital were selected as study group,and other 31 normal skin tissues were selected as control group.Immunohistochemical technique was used in two groups.Optical microscopy was used for visual field detection.At the same time,the average optical density was used as the evaluation index,and the average value as average optical density of cell sections.ResultsThe average optical density of P16 and PTEN in basal cell carcinoma was lower than that in normal skin tissue(P<0.05).The average optical density of CyclinD1 in basal cell carcinoma was significantly higher than that in normal skin tissue (P<0.05).ConclusionP16,PTEN and CyclinD1 may be related to the occurrence and development of basal cell carcinoma of the skin.
2017 Vol. 24 (12): 150-152 [
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116
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Study on the clinical application of Th17 cell-associated cytokines and anti-CCP antibody test in rheumatoid arthritis
YU Xiu-hua;ZHOU Gui-tao;YANG Xiu-tang
ObjectiveTo investigate the correlation and clinical significance of Th17-related cytokines and anti-CCP antibodies in rheumatoid arthritis.Methods60 patients with rheumatoid arthritis(RA)who were treated in our hospital from January 2015 to May 2016 were retrospectively analyzed.According to DAS28 scores,the patients were divided in to active group of 32 patients(DAS28>3.2)and stable group of 28 patients(DAS28≤3.2).Another 60 healthy subjects were selected as the control group.Serum Th17-related cytokines(IL-17,IL-6,TGF-β1)were determined by ELISA,and the positive rate of anti-CCP antibody was detected by colloidal gold immunochromatography.The testing results were compared between the three groups.ResultsThe positive rate of anti-CCP:active group＞stable group＞control group(P＜0.05). IL-17 and IL-6 levels:active group＞stable group＞control group(P<0.05).TGF-β1 level:active group＜stable group＜con trol group (P＜0.05).ConclusionThe higher of the positive rate of anti-CCP antibody,the level of IL-17 and IL-6,the higher DAS28 score of RA,and the higher of level of TGF-β1,the lower of the DAS28 score of RA.Therefore,Th17-related cytokines and anti-CCP antibodies can improve the sensitivity and specificity of RA diagnosis and activity judgment,providing the basis for new treatment strategies.
2017 Vol. 24 (12): 153-155 [
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128
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Clinical significance of GICA in detection of Dengue virus NS1 antigen and/or IgG/IgM antibody
ZHONG Xiu-yin;YANG Xiao-bin;HE Xiang-juan;HUANG Shao-xia;CAI Yi
ObjectiveTo analyze and explore the effect of application of colloidal gold immunochromatography assay (GICA)in the detection of Dengue virus NS1 antigen and/or IgG/IgM antibody.MethodsAltogether 1200 cases of suspected Dengue virus infection patients who were treated in our hospital from January 2014 to June 2015 were involved as the object of this research and divided into two groups(PCR group and ELISA group)by using the random grouping method,with 600 casesin each group.Two groups were treated with polymerase chain reaction(PCR)fluorescence probe and enzyme-linked immunosorbent assay(ELISA),respectively.The two types of samples aforementioned were randomly divided into 3 sub-groups,with 200 samples in each sub-groups:GICA was used in group A to detect NSI antigen;GICA was used in group B to detect IgG/IgM antibody;it was also used in group C for detection of NS1 antigen and IgG/IgM antibody.Additionally,60 healthy volunteers were selected as Group D,whose NS1 antigen and IgG/IgM antibody were detected by using GICA.ResultsELISA group results:compared with the results of ELISA group,the positive,negative and overall coincidence rate of group A were 82.88%,90.00%and 83.00%,with statistically significant difference(P<0.05);compared with the results of ELISA group,the positive,negative and overall coincidence rate of group B were 88.20%,71.79%and 85.00%,with statistically significant difference(P<0.05);compared with the results of ELISA Group,the positive,negative and overall coincidence rate of group A were 94.87%,47.73%and 84.50%,without statistically significant difference(P>0.05);PCR group results:compared with the results of PCR group,the positive,negative and overall coincidence rate of group A were 87.68%,83.87% and 86.50%,with statistically significant differenc(P< 0.05);compared with the results of PCR group,the positive,negative and overall coincidence rate of groupB were 91.45%,85.42%and 90%,with statistically significant difference(P<0.05);compared with the results of PCR Group,the positive,negative and overall coincidence rate of Group B were 95.43%,60.00%and 91.00%,without statistically significant difference(P>0.05).The result of Group D was negative and its specificity was 100%.ConclusionThe result achieved by application of GICA is close to that of ELISA and PCR in detection of NIS and IgG/IgM with good specificity.tcan be used for early screening and diagnosis of dengue virus infections.
2017 Vol. 24 (12): 156-158转163 [
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Analysis of thalassemia gene screening in 1071 cases
CHEN Yu-hua ZHOU Bi-yun LIANG Si-si WU Xian-jin LI Hai-yan
ObjectiveTo investigate the genetic heterogeneity of thalassemin of patients in our hospital and the diagnostic value of mean corpuscular volume(MCV)and mean corpuscular hemoglobin(MCH)in thalassemia screening.MethodsFrom December 2015 to September 2016,1071 patients with thalassemia in our hospital were selected,gap-PCR and polymerase chain reaction-reverse dot blot(PCR-RDB)were used to test α-thalassemia gene and β-thalassemia gene,hematology analyzer was used to test mean corpuscular volume (MCV)and mean corpuscular hemoglobin(MCH)of 904 patients.Results①Among the 1071 cases,556 cases was male and 515 cases was female,the positive rate of thalassemia was 41.37%(230 cases)for male and 46.21%(238 cases)for female,which was displayed no statistical differences in the two groups(χ2=2.55,P>0.05).②During different group such as children group(0-16 years old, 360 cases),adult group(17-49 years old,651 cases)and senior group(≥ 50 years old,60 cases),the positive rate of thalassemia was 48.33%(174 cases),42.7%(278 cases)and 26.67%(16 cases),respectively,which was displayed statistical differences among the groups(χ2=10.48,P<0.01).③among 1071specimens,293 cases(27.36%)were diagnosed as α-thalassemia and 157 cases(14.66%)were diagnosed as β-thalassemia.Among the α-thalassemia genotypes,αα/--SEA,-α3.7/αα,αα/-α4.2 were the most common genotypes(93.86%);among the β-thalassemia genotypes,CD41-42,IVS-Ⅱ-654,-28,CD71-72,CD17werethemostcommon genotypes(82.81%);18 cases(1.68%)were diagnosedas α-thalassemia combined with β-thalassemia.④The diagnostic sensitivity of MCV for α-thalassemia,β-thalassemia and αβ-thalassemia screening were 91.18%,99.21%and 92.31%,respectively,and 54.18%for the diagnostic specificity. The diagnostic sensitivity of MCH for α-thalassemia,β-thalassemia and αβ-thalassemia screening were 94.12%, 99.21%and 100.00%,respectively,and 51.90%for the diagnostic specificity.The diagnostic sensitivity of MCV+MCH for α-thalassemia,β-thalassemia and αβ-thalassemia screening were 89.08%,99.21%and 84.62%,respectively,and 49.24%%for the diagnostic specificity.There was no significant difference in the sensitivity and specificity between MCV and MCH(χ2=1.77,P>0.05;χ2=0.55,P>0.05).Conclusionαα/-SEA genotype and βCD41-42 genotype are the most common type in α-thalassemia and β-thalassemia in 1071 patients with thalassemia,it is reasonable to screening the thalassemia by MCV combine with MCH.
2017 Vol. 24 (12): 159-163 [
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Nursing experience of open posterior peritoneal inguinal hernia repair
GAN Mei;XU Xiao-yun
ObjectiveTo explore the nursing experience of open posterior peritoneal inguinal hernia repair.Methods80 cases of inguinal hernia patients in our hospital from January to November 2016 were selected and randomly divided into two groups,with 40 cases in each group.They were all
received：
open posterior peritoneal inguinal hernia repair.Patients in the control group were given routine care,while patients in the observation group were given comprehensive care.The incidence of postoperative complications and the quality of life were compared between the two groups.ResultsThe incidence of postoperative complications in the observation group(2.5%)was lower than that in the control group (17.5%),the difference was statistically significant(P＜0.05).Before nursing,there were no significantly different among the scores of indexes in SCL-36 in two groups(P＞0.05);after nursing,the scores of indexes in SCL-36 in two groups were all increased,and compared with those before nursing,the differences were statistically significant(P＜0.05).And those in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).ConclusionComprehensive nursing open posterior peritoneal inguinal hernia repair surgery can decrease the risk of complications,and improve the quality of life,the effect is very satisfactory.
2017 Vol. 24 (12): 164-166 [
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Preventive effect of predictive nursing on pulmonary infection during perioperative period of craniocerebral operation
YANG Jian-e;HUANG Ju
ObjectiveTo explore the preventive effect of predictive nursing on pulmonary infection during perioperative period of craniocerebral operation.Methods150 patients who underwent the craniocerebral operation in our hospital from January to December 2012 were selected as the control group.200 patients who underwent the craniocerebral operation from June 2013 to May 2014 were selected as the observation group.Patients in the control group were
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conventional nursing,while patients in the observation group were received predictive nursing care.The incidence of pulmonary infection,length of ICU stays,intubation time,length of hospital stays of two groups were compared.ResultsThe incidence of pulmonary infection in the observation group(14.50%)was lower than that in the control group(32.67%), the difference was statistically significant(P<0.05);the length of ICU stays[(20.11±4.58)d],intubation time[(18.25±4.69)d], length of hospital stays[(31.02±4.98)d]in the observation group were shorter than those in the control group[(25.24± 5.69),(22.31±4.08),(38.44±6.05)d],the differences were statistically significant(P<0.05).ConclusionThe preventive nursing intervention in perioperative period of craniocerebral operation can effectively reduce the incidence rate of pulmonary infection,and improve postoperative respiratory function status,it is great significance to promote postoperative rehabilitation,thus it is worthy to be promoted.
2017 Vol. 24 (12): 167-169 [
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Effect of different concentrations of heparin-encapsulated liquid on intravenous indwelling needle sealing in diabetic patients
ZHANG Jie-jun
ObjectiveTo explore the effect of three different concentrations of heparin sealant on intravenous indwelling needle sealing in diabetic patients.Methods90 patients with diabetes mellitus in our hospital from June 2009 to May 2012 were selected and randomly divided into three groups,with 30 patients in each group.Group A used 125 U/ml heparin sealant 5 ml,group B used 100 U/ml heparin sealant 5 ml,and group C used 150 U/ml heparin sealant 5 ml.The incidence of repeated puncture and patency after sealing,the level of fibrin,APTT and PT were compared between two group.ResultsThe incidence of repeated puncture in group B(3.33%)was lower than that in group A(20.00%)and C (33.33%),the incidence of patency after sealing in group B(93.33%)was higher than that in group A(66.67%)and C (50.00%),and the differences were statistically significant(P<0.05).The level of fibrin,APTT and PT of group B was better than that in group A and C,and the differences were statistically significant(P<0.05).ConclusionHeparin sealed liquid concentration of 5 ml 100 U/ml(tube concentration 500 U)with the most effective sealing effect,it will be used in patients with diabetes intravenous indwelling needle,can reduce the blocking rate.
2017 Vol. 24 (12): 170-172 [
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Application of modified restraint strap in patients with restlessness
YU Hua;ZHAO Qin-qin;YANG Ling
ObjectiveTo explore the application value of modified restraint strap in patients with restlessness.Methods92 patients with restlessness in our hospital from May 2014 to June 2015 were selected and randomly divided into the observation group and the control group,with 46 cases in each group.Patients in the control group were given traditional restraint strap,while the observation group were given modified restraint strap.The incidence of extubation,unexpected skin damage and swelling of infusion area of two groups were compared.ResultsThe incidence of extubation,unexpected skin damage and swelling of infusion area of the observation group(0.00%,4.35%,6.52%)were lower than those of the control group(15.22%,19.57%,23.91%),and the differences were statistically significant(P<0.05).ConclusionModified restraint strap is a safe,effective,economic and comfortable restraint method.It can effectively prevent extubation,unexpected skin damage,swelling of infusion area in patients with restlessness,increase patients′comfort,which is worthy of promotion and application.
2017 Vol. 24 (12): 173-175 [
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Effect of system care intervention on the level of maternal breastfeeding and the rate of breastfeeding in pregnant women combined with complications
SUN Ying-qi
ObjectiveTo explore the effect of system care intervention on the level of maternal breastfeeding and the rate of breastfeeding in pregnant women combined with complications.Methods112 patients with gestational complications from December 1st2014 to December 1st2016 in department of obstetrics and gynecology in our hospital were selected and randomly divided into observation group and control group,with 56 cases in each group.Patients in observation group were given system care intervention,while patients in control group were given routine nursing intervention. The maternal breastfeeding awareness and breastfeeding rate of two groups were compared.ResultsThe maternal breastfeeding awareness in observation group(96.43%)was higher than that in the control group(80.37%),and the difference was statistically significant(χ2=12.527,P=0.000).The breastfeeding rate in observation group (96.43%)was higher than that in the control group(75.00%),and the difference was statistically significant(χ2=10.856,P=0.000).ConclusionSystematic nursing intervention can improve the pregnancy miscarriage of pregnant women on breastfeeding awareness and breastfeeding rate and can be used in clinical practice.
2017 Vol. 24 (12): 176-178 [
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Effect of emergency nursing process on patients with traumatic shock
YANG Qiu-na
ObjectiveTo explore the effect of emergency nursing process on patients with traumatic shock.MethodsClinical data of 80 cases of patients with traumatic shock who were treated in department of emergency in our hospital from January 2014 to December 2015 were analyzed and divided into control group and observation group according to different emergency nursing processes.Monitoring of vital signs and maintaining airway patency were performed for 40 cases in control group(conventional emergency procedures);the injury assessment,recovery of effective circulation process, dynamic condition monitoring,preoperative preparation,organization and coordination and psychological nursing measures were performed for 40 cases in observation group(emergency nursing process).The duration from admission to the accurate diagnosis time,first-aid implementation time,preoperative preparation time,emergency time,hospitalization time, first-aid success rate,mortality rate of two groups of patients were compared.ResultsThe duration from admission to the accurate diagnosis time,first-aid implementation time,preoperative preparation time,emergency time and hospitalization time in observation group[(25.7±9.6)min,(40.2±10.6)min,(50.2±13.6)min,(42.4±12.8)min and(17.6±5)d]were shorter than those in control group[(40.8±12.3)min,(66.7±15.8)min,(70.9±16.4)min,(64.2±14.1)min and(25.5±7.6)d]. The first-aid success rate of observation group(100.0%)were higher than that in control group(90.0%).The mortality rate of observation group(0.0%)were lower than that in control group(7.5%).All the differences were statistically significant (P<0.05).ConclusionApplication of emergency nursing process in patients with traumatic shock can improve the efficiency of first aid and reduce the time of first aid and hospital stay so as to improve the success rate of emergency treatment and reduce the mortality rate.
2017 Vol. 24 (12): 179-181 [
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Application effect of cluster nursing intervention on ventilator associated pneumonia in ICU elderly patients
LIANG Min-qiong;HU Wan-ni;YANG Wen-xian
ObjectiveTo investigate the application effect of cluster nursing intervention on ventilator associated pneumonia(VAP)in ICUelderly patients.Methods79 cases of ICU elderly patients in our hospital from August 2015 to November 2016 were selected and divided into control group(n=39)and observation group(n=40)according to the random number table method.Patients in the control group were given routine nursing care,while patients in the observation group were given the cluster nursing on the basis of control grou.The mechanical ventilation time,ICU stay,total hospital stay,the incidence of ventilator-associated pneumnia and mortality of two groups were compared.ResultsThe mechanical ventilation time,ICU stay,total hospital stay in the observation group[(15.5±4.6),(17.4±6.3),(23.3±7.1)d]were shorter than that in the control group [(20.1±5.8),(22.6±6.4),(34.6±6.9)d].The incidence of ventilator-associated pneumnia and mortality of the observation group(27.5%,15.0%)were shorter than that in the control group(53.8%,48.7%).All the the differences were statistically significant(P<0.05).ConclusionIn the treatment of elderly ICU patients with VAP disease,the cluster nursing intervention can effectively shorten the mechanical ventilation time,hospitalization time,reduce the incidence of VAP and mortality,and promote the recovery of the patients.
2017 Vol. 24 (12): 182-184 [
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Evaluation of the effect of comfortable nursing model on the recovery of patients with acute ischemic stroke
HONG Cai-xia ;GUO Qiao-li;ZHANG Xue-ling
ObjectiveTo explore the clinical effect of comfortable nursing model in patients with acute ischemic stroke during rehabilitation.Methods88 patients diagnosed with acute ischemic stroke and in convalescence in our hospital from January 2014 to December 2016 were selected and randomly divieded into the experiment group and the control group,with 44 cases in each group.Patients in the control group were given routine nursing,while patients in the experiment group were given routine nursing combined with comfort care nursing model.The scores of SDS,SAS,ESS,FMA,BI and the degree of satisfaction of patients in two groups were compared.ResultsBefore nursing,there were no significantly different among the scores of SAS,SDS,ESS,FMA,BI in two groups(P＞0.05);after nursing,the scores of SAS,SDS in observation group was lower than those in control group,and the scores of ESS,FMA,BI in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).The degree of satisfaction of patients in observation group was higher than that in control group,and the difference was statistically significant(P＜0.05).ConclusionIt is beneficial to improve the mental state (anxiety and depression)and the neurological,motor and selfcare function of patients with acute ischemic stroke during the rehabilitation period,and promote the improvement of nursing satisfaction.
2017 Vol. 24 (12): 185-187 [
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188
pplication of pneumatic therapeutic apparatus in patients with severe medical
LIU Jian
ObjectiveTo explore the application effect of pneumatic therapy instrument in patients with severe medical department.Methods85 patients′clinical data with severe medical treatment in our hospital from April 2014 to April 2016 were selected.According to the nursing method,the patients were divided into study group (n=45)and control group (n=40).The control group was given routine care,the study group on the basis of conventional care to give pressure therapy instrument care.The peak velocity and mean velocity of femoral vein before and after treatment were compared between the two groups,and the total effective rate of deep venous thrombosis was compared between the two groups.ResultsThe lower extremity swelling and deep vein thrombosis rate(4.44%,4.44%)in the study group were significantly lower than those in the control group(22.50%,95.56%)was higher than that of the control group(77.50%).The total effective rate of prevention of deep vein thrombosis was higher than that of the control group,and the difference was statistically significant(P<0.05).ConclusionThe application of pneumatic therapy instrument care in patients with intensive care,can effectively increase the peak blood flow velocity and the average speed,so as to effectively prevent the formation of deep vein thrombosis.
2017 Vol. 24 (12): 188-190 [
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Effect of pain relief delivery nursing on the delivery mode and labor pain of primipara
ZHENG Hong-lian
ObjectiveTo analyze the effect of pain relief delivery nursing on the delivery mode and labor pain of primipara.MethodsAltogether 200 cases of primiparas who gave childbirth in our hospital from March 2015 to January 2016 were selected as the objects of this research and divided into two groups(control group and observation group)according to the order of admission,with 100 cases in each group;control group was given routine nursing intervention; while observation group was given pain relief delivery nursing;the delivery mode and labor pain of two groups were observed and compared.ResultsThe labor pain visual analogue scale(VAS),present pain intensity(PPI)and verbal rating scale(VAS)scores of observation group were significantly lower than those of control group(P<0.05);in addition to the third stage of labor,each stage of labor of observation group was significantly shorter than that of control group(P<0.05); the vaginal deliveryrate of observation group was significantly higher than that of control group(P<0.05).ConclusionPain relief delivery nursing for primiparas can effectively meet the demand of primiparas during childbirth,reduce the labor pain,shorten the labor timeand increase the vaginal delivery rate,which is of great significance in clinical application and popularization.
2017 Vol. 24 (12): 191-193 [
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Effect of integrated traditional Chinese and Western medicine nursing on improvement of postpartum lactation in parturients with cesarean section
ZHANG Xiao-xia
ObjectiveTo explore the clinical effect of integrated traditional Chinese and Western medicine nursing on shortening the time of lactation and increasing of lactationyield in parturients with cesarean section.MethodsAltogether 136 cases of parturients who underwent cesarean section from June 2015 to September 2016 in our hospital were randomly divided into control group and observation group,68 cases in each group.The control group was given routine nursing;while,the observation group was given integrated traditional Chinese and Western medicine nursing.The maternal lactation time,postpartum lactation yield and breast tenderness of two groups were compared.ResultsThe average postpartum lactation time and above-average postpartum lactation yield of observation group were better than those of control group(P<0.05);while,the postpartum 48-hour breast tenderness of observation group was statistically different in contrast with that of control group(P<0.05).ConclusionIntegrated traditional Chinese and Western medicine nursing can shorten the maternal lactation time,improve the lactation yield and significantly remit postpartum breast tenderness, which is worthy of clinical application.
2017 Vol. 24 (12): 194-196 [
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