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| Diagnostic value of transvaginal three-dimensional ultrasound combining with blood human chorionic gonadotropin in endometrial carcinoma |
| ZHENG Xiao-hong1 CHEN Feng-chun2 ZHU Li-min1 LUO Li-fang1 DENG Jin-yao1 ZHU Yan-fang1 QUAN Xiao-guang1 |
1.Department of Ultrasound,Maternal and Child Health Care Hospital of Nanhai District of Foshan City in Guangdong Province,Foshan 528200,China;
2.Department of Obstetrics and Gynecology,the Fourth People′s Hospital of Nanhai District of Foshan City in Guangdong Province,Foshan 528211,China |
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Abstract ObjectiveTo investigate the diagnostic value of transvaginal three-dimensional ultrasonography combining with human chorionic gonadotropin(HCG)in patients with endometrial carcinoma.MethodsFrom August 2015 to October 2016,90 patients with vaginal bleeding for more than two years after postmenopausal period were collected in our hospital and the Fourth People′s Hospital of Nanhai District and divided into the endometrial hyperplasia group(n=64) and the endometrial carcinoma group(n=26)according to histopathological examinations.The endometrial thickness and volume were measured by transvaginal three-dimensional ultrasonography in both groups.The level of serum β-HCG was determined by chemilumineseent immunoassay (CLIA).The endometrial thickness and volume as well as serum β-HCG level were compared in the two groups.Besides,correct diagnostic rate,the rate of missed diagnosis,misdiagnosis rate,sensitivity,specificity,positive predictive value,negative predictive value,and accuracy on benign and malignant diseases of serum HCG,three-dimensional ultrasonography and three-dimensional ultrasonography combining with serum HCG were compared.ResultsIn the endometrial carcinoma group,endometrial thickness,volume was larger than that in the endometrial hyperplasia group,and serum β-HGC level was higher than that in the endometrial hyperplasia group, with significant difference (P＜0.05).The correct diagnostic rate was higher and the misdiagnosis rate and rate of missed diagnosis were both lower by three-dimensional ultrasonography combining with serum HCG.In comparison with threedimensional ultrasonography combining with serumHCG,sensitivity,specificity,positive predictive value,negative predictive value,and accuracy by serum HCG or three-dimensional ultrasonography only were all lower,which was displayed statisticaldifference(P＜0.05).ConclusionTransvaginal three-dimensional ultrasonography combining with serum HCG can improve the diagnosis rate of early-stage of endometrial carcinoma with higher sensitivity and specificity,which provides the basis for early diagnosis and treatment by physicians,so that more patients will get early treatment.It greatly improve patients′prognosis and is of great significance.
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