硫利达嗪联合氯雷他定抑制胃肠道肿瘤作用的研究

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Abstract ObjectiveTo discuss the preliminary effect of nervous system drugs on gastrointestinal tumors.MethodsThioridazine,Loratadine,Scopolamine,Dopamine,Acetylcholine and Estazolamum(0.01,0.1,1,10,100 μmol/L),six classical nervous system drugs were selected to detect the activities of gastrointestinal tumor in vitro by using CCK-8 assay.The spleen cells of mice were also used as the model to study the safety of the nervous system drugs in vitro.ResultsAmong six classical nervous system drugs,cell growth on human colon and gastric cancer clells were suppressed by 100 μmol/L scopolamine,100 μmol/L Loratadine and 10 μmol/L Thioridazine (P<0.05),especially the combination of Thioridazine and Loratadine.Six drugs only played roles in killing tumors cells,while the spleen lymphocytes of normal mice were non-toxic.The growth of mouse gastrointestinal carcinoma cells in vitro were inhibited by 10 μmol/L thioridazine and 25 μmol/L Loratadine.ConclusionThioridazine combined with Loratadine is proved to enhance anti-gastrointestinal tumor effects in vitro,and provides a new strategy for forward combination treatment.

Key words： Thioridazine Loratadine Nervous system drugs Gastrointestinal tumor Combination therapy

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	ZHANG Jin-mei
	KANG Wen-quan
	JIN Guang-yi
	CHEN Ting-ting

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ZHANG Jin-mei,KANG Wen-quan,JIN Guang-yi, et al. Study of the effect of Thioridazine combined with Loratadine on the gastrointestinal tumor suppressor[J]. 中国当代医药, 2017, 24(12): 4-8.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I12/4

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