Objective To investigate the efficacy and safety of high-flow nasal cannula oxygen therapy (HFNC) in idiopathic pulmonary fibrosis (IPF) with respiratory failure. Methods A total of 90 patients with IPF and respiratory failure who were admitted in the hospital from May 2019 to April 2020 were selected, and they were divided into group A(nasal catheter oxygen uptake), group B [non-invasive positive pressure ventilation (NPPV)]and group C (HFNC) according to random number table method, with 30 cases in each group. The arterial blood gas (partial pressure of carbon dioxide [PaCO2], partial pressure of oxygen [PaO2], oxygen saturation [SpO2], power of hydrogen [pH]), 6-minute walking test (6MWT) distance, vital signs (heart rate and respiratory rate) and adverse reactions (incidence of nasal cavity dryness, nasal mucosal hemorrhage, flatulence, degree of xerostomia) were compared among the three groups. Results There were no statistically significant differences in the levels of PaCO2 and pH among the three groups before and after treatment (P＞0.05); the levels of PaO2 and SpO2 in the three groups after treatment for 1, 3 and 7 d were higher than those before treatment, the differences were statistically significant(P＜0.05); the levels of PaO2 and SpO2 in group B and group C were higher than those in group A after treatment for 1, 3 and 7 d, the differences were statistically significant(P＜0.05); there were no statistically significant differences in the levels of PaO2 and SpO2 between group B and group C after treatment for 1, 3 and 7 d (P＞0.05); the 6MWT distance of the three groups after treatment for 7 d was longer than that before treatment, the heart rate and respiratory rate were lower than those before treatment, the 6MWT distance of group B and group C was longer than those of group A, and the heart rate and respiratory rate of group B and group C were lower than those of group A, the differences were statistically significant (P＜0.05); there was no statistically significant difference in the 6MWT distance and vital signs between B group and C group after treatment for 7 d (P＞0.05); the incidence rates of nasal dryness, nasal mucosal bleeding, and flatulence in group C was lower than that of group A and group B, and the differences were statistically significant (P<0.05); the degree of dry mouth in the three groups was compared, group C was lighter than group A and group B, the difference was statistically significant(P<0.05). Conclusion HFNC in IPF with respiratory failure has significant effect, it can regulate arterial blood gas, stabilize vital signs, reduce adverse reactions, and relieve the degree of xerostomia of the patients.

Objective To explore the changes of renal function when the Vancomycin at a minimum concentration (Cmin)was first detected after intravenous administration of vancomycin, and to evaluate the correlation between blood concentration of Vancomycin and renal function indicators. Methods A total of 61 patients with severe brain injury and Gram-positive cocci (G+) pneumonia hospitalized in the Neuro-Intensive Care Unit of the 904th Hospital of the PLA(formerly 101 Hospital) from January 2015 to December 2017 were selected. The biochemical indicators including blood urea nitrogen (BUN), serum creatinine (SCr), β2 microglobulin (β2-MG), α1 microglobulin (α1-MG), cystatin C(Cys-C) before Vancomycin and 48 hours after medication were tested. The estimated glomerular filtration rate (eGFR)and Vancomycin concentration were calculated using Modification of Diet in Renal Disease. Statistical analysis was performed on the renal function indicators before and after medication, and the correlation between Vancomycin plasma concentration and renal function indicators was analyzed using multiple correlation analysis and multiple linear regression analysis. Results After treatment, the levels of β2-MG and Cys-C were higher than those before treatment, and the differences were statistically significant (P＜0.05). There were no statistical differences in the levels of BUN, SCr, and α1-MG before and after treatment (P＞0.05). After treatment, the eGFR level was lower than that before treatment, and the difference was statistically significant (P＜0.05). The blood concentration of Vancomycin was positively correlated with the levels of BUN, SCr, β2-MG and Cys-C (r=0.468, 0.612, 0.733, 0.751, P＜0.05), negatively correlated with the level of eGFR (r=-0.575, P＜0.05), and not correlated with the level of α1-MG (P＞0.05). Conclusion Forty-eight hours after using Vancomycin, indicators such as β2-MG and Cys-C increases significantly and eGFR decreases, suggesting that β2-MG, Cys-C, and eGFR are early sensitive indicators. The blood concentration of Vancomycin is positively correlated with the levels of BUN, SCr, β2-MG, and Cys-C, and negatively correlated with the level of eGFR.

Objective To evaluate the effect of low-dose Aspirin on uterine arterial blood flow and endometrium after transcervical resection of adhesion. Methods PubMed, Web of Science, MEDLINE, CNKI, Wanfang and other databases were searched, the retrieval time was from the database construction to December 2019, strict inclusion and exclusion criteria were formulated, quality evaluation of included literature was conducted, and Review Manager 5.3 software was used for Meta-analysis. Results Finally, 7 random control trial (RCT) articles were included. The results of Metaanalysis showed that the uterine artery resistance index (RI) in the experimental group was lower than that in the control group, and the difference was statistically significant (WMD=-0.17, 95%CI[-0.19, -0.14], P<0.000 01). The pulsatility index (PI) in the experimental group was lower than that in the control group, and the difference was statistically significant (WMD=-0.33, 95%CI[-0.49, -0.17], P<0.0001). The endometrial vascularization index (VI) in the experimental group was higher than that in the control group, and the difference was statistically significant (WMD=1.01,95%CI[0.46, 1.55], P=0.0003). The blood flow index (FI) and vascularized blood flow index (VFI) in the experimental group were higher than those in the control group, and the differences were statistically significant (WMD=4.53, 95%CI[3.45,5.61],P<0.000 01;WMD=0.30,95%CI[0.24,0.35],P<0.000 01).The proportion of type A endometrium in the experimental group was higher than that in the control group, and the difference was statistically significant (OR=3.01, 95%CI [1.38, 6.60], P=0.006). Conclusion The application of low-dose Aspirin after transcervical resection of adhesion can improve the uterine artery blood flow, increase endometrium perfusion and the proportion of type A endometrium, promote the repair of endometrium.

Objective To investigate the predictive value of high sensitivity C-reactive protein and albumin ratio and plasma copeptin (CPP) on major adverse cardiovascular events (MACE) in patients with coronary heart disease and chronic heart failure. Methods Eighty-six hospitalized patients with coronary heart disease and chronic heart failure in People′s Hospital of Huaiyin Ji′nan from March 2018 to June 2019 were selected. According to the occurrence of MACE within 6 months, the patients were divided into the MACE group (36 cases) and the non-MACE group (50 cases). The data of all patients were collected, the serum brain natriuretic peptide (BNP), CPP levels, high-sensitivity C-reactive protein/albumin ratio and left ventricular ejection fraction (LVEF) were detected, and receiver operating characteristic (ROC) curve was used to evaluate the predictive value of high-sensitivity C-reactive protein/albumin ratio and CPP for MACE in patients with coronary heart disease and chronic heart failure. Results The high-sensitivity C-reactive protein/albumin ratio, plasma BNP and CPP levels of the MACE group were higher than those of the non-MACE group, and the LVEF was lower than that of the non-MACE group, the differences were statistically significant(P<0.05). The area under the curve (AUC) of MACE in patients with coronary heart disease and chronic heart failure predicted by the high-sensitivity C-reactive protein/albumin ratio was 0.826, P=0.000, 95%CI (0.735-0.917), which had certain diagnostic significance. The AUC of MACE in patients with coronary heart disease and chronic heart failure predicted by the plasma CPP was 0.714, P=0.000, 95%CI (0.604-0.824), which had certain diagnostic significance. The AUC was 0.865 in the occurrence of MACE in patients with coronary heart disease and chronic heart failure predicted by combination of high-sensitivity C-reactive protein/albumin ratio and plasma CPP, which was better than the above two independent indicators. Conclusion The high-sensitivity C-reactive protein/albumin ratio and CPP can be used as biomarkers for early prediction of MACE in patients with coronary heart disease and chronic heart failure.

With the progress of medical technology, the survival rate of women of childbearing age with malignant diseases has been significantly improved after treatment, and the demand for a good quality of life after the disease has become increasingly strong. Premature ovarian failure (POF) after hematopoietic stem cell transplantation (HSCT) has been an important reason for the improvement of patients′ quality of life. Based on the clinical experience of professor Lei Lei, this paper discusses the possibility of integrated traditional Chinese and Western medicine in improving POF after HSCT. Professor Lei Lei treats from deficiency, takes tonifying as the method, applies Jiawei Sierwu prescription combined with hormone replacement therapy, supplemented by traditional Chinese medicine retention enema, and pays attention to the treatment of body and mind at the same time, so as to provide a more efficient and safer way for clinical treatment of related diseases.

Pyroptosis is a pattern of atypical cell death driven by inflammasome, mediated by Caspase-1/-11/-4/5.Gasdermin family proteins are identified as pore-forming proteins acting as the "executor" of pyroptosis, which usually remain in self-suppressed state. Gasdermin D and Gasdermin E are the most key palyers in pyroptosis. In the pathway of pyroptosis, GSDMD/GSDME is cleaved into N-terminal pore-forming fragments and C-terminal inhibitory fragments by activated Caspases, membrane perforation is initiated in turn, and cell contents such as inflammatory factors are released to trigger pyroptosis. Emerging evidences support that pyroptosis plays an important role in the development of various diseases, especially in tumors. This article summarizes the underlying molecular mechanism of pyroptosis and reviews the research progress in cancer.

With the development of country′s economy and changes in living habits, the prevalence of myopia in adolescents is increasing year by year, seriously endangering the physical and mental health of adolescents. China has a high prevalence of myopia, and it is urgent to prevent and control myopia among young people. For patients with rapid myopia progression, orthokeratology can effectively reshape the cornea, reduce refractive errors and inhibit the elongation of eye axis. Moreover, orthokeratology has been clinically proved to be effective in controlling the progression of myopia among young people, and its safety and reversibility have been widely recognized by scholars. However, the mechanism of orthokeratology in controlling myopia has not been clarified. Currently, peripheral refraction theory is widely accepted while some others have pointed out that orthokeratology may control myopia by improving the eye accommodation and reducing retina defocusing. This article reviews the changes in the accommodation function of myopia patients after wearing orthokeratology.

Objective To explore the application of Shenglong Jiegu Capsules in the healing of middle-aged and elderly distal radius fractures. Methods A total of 60 middle-aged and elderly patients with distal radius fractures over the age of 50 who were treated in our hospital from June 2018 to November 2019 were selected as the research objects.They were divided into three groups by random number table method, 20 cases in each group. Group A was given manual reduction and splint fixation, group B was orally administered with Xianling Gubao Capsules on the basis of treatment in group A, group C was orally administered with Shenglong Jiegu Capsules on the basis of treatment in group A.The clinical efficacy, fracture healing and wrist function of the three groups were compared. Results The total effective rate of clinical treatment in group C was higher than that in group A and group B, and the fracture healing time was shorter than that in group A and group B, the differences were statistically significant (P＜0.05). After 6 and 12 weeks of treatment, the total scores of the three groups of patient-rated wrist evaluation (PRWE) were lower than those in this group before treatment, and the total score of the PRWE in group C was lower than that in group A and group B, the differences were statistically significant (P<0.05). Conclusion Shenglong Jiegu Capsules can improve the clinical efficacy of middle-aged and elderly distal radius fractures, shorten the fracture healing time, and promote the recovery of wrist joint function.

Objective To observe the nutritional status of senile patients with blood disease, and to analyze its influencing factors. Methods The clinical data of 60 senile patients with blood disease who treated in our hospital from January 2018 to October 2019 were retrospectively analyzed, and divided into malnutrition group (25 cases) and normal nutrition group (35 cases) according to nutritional status of patients. The gender, age, body mass index (BMI), dialysis time,albumin (ALB), total protein (TP) and anxiety/depression ratio of patients with different nutritional status were compared, and the influencing factors of malnutrition were analyzed. Results The incidence of malnutrition in 60 senile patients with blood disease was 41.67%. The score of mini-nutritional assessment (MNA) in malnutrition group was lower than that in normal nutrition group, and the difference was statistically significant (P<0.05). The single-factor analysis results indicated that there were statistically significant differences in the BMI, dialysis time, ALB and TP between malnutrition group and normal nutrition group (P<0.05). The multiple-factor analysis results indicated that BMI(β=1.404, OR=4.073, 95%CI=1.366-12.143), dialysis time (β=1.636, OR=5.136, 95%CI=1.685-15.650), ALB (β=1.725,OR=5.610, 95%CI=1.817-17.326), TP (β=1.670, OR=5.312, 95%CI=1.741-16.206) were influencing factors for malnutrition in senile patients with blood disease (P<0.05). Conclusion BMI, dialysis time, ALB, TP are related influencing factors for malnutrition in senile patients with blood disease. The above factors can be observed and intervened in the clinic to prevent and control the malnutrition in patients.

Objective To explore the application effect of early anti-anxiety in patients with Sjogren′s syndrome.Methods A total of 100 patients with Sjogren′s syndrome admitted in our hospital from August 2018 to August 2019 were selected as the research objects, and they were divided into the control group (50 cases) and the observation group(50 cases) according to the random number table method. The control group received routine nursing, and the observation group received early anti-anxiety. The improvement effect of adverse emotions and quality of life were compared between the two groups. Results The scores of self-rating depression scale (SDS) and self-rating anxiety scale (SAS) of the two groups after intervention were lower than those before intervention, the differences were statistically significant(P＜0.05). The SDS and SAS scores of the observation group after intervention were lower than those of the control group, and the quality of life scores (eating function, psychological function, social function and material life) of the observation group after intervention were higher than those of the control group, the differences were statistically significant (P＜0.05). The intervention satisfaction score of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Early anti-anxiety measures in the treatment of Sjogren′s syndrome can significantly reduce the anxiety and depression of patients, and help to improve the quality of life and patient satisfaction.

Objective To explore the application effect of electrocardiogram (ECG) positioning technology assistance in intravenous infusion port. Methods From February 2019 to February 2020,50 patients in the oncology department of our hospital who need to have intravenous infusion port were selected as the research objects. According to the random number table method, they were divided into the observation and control groups, 25 cases in each group. In the observation group, ECG positioning technology was used to assist in the placement of intravenous infusion port, while in the control group, the traditional blind puncture method was used. The accuracy of catheter tip location, operation time, complications and satisfaction were compared between the two groups. Results The accuracy of catheter tip location in the observation group was higher than that in the control group, and the operation time in the observation group was shorter than that in the control group, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).The total satisfaction of the patients in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion ECG positioning technology can improve the accuracy of intravenous infusion port, improve work efficiency and reduce the risk of complications, which is worthy of clinical recommendation.

objective To explore the clinical effect of Azithromycin combined with Methylprednisolone in the treatment of refractory Mycoplasma pneumonia. Methods A total of 46 patients with refractory Mycoplasma pneumonia admitted to our hospital from June 2016 to June 2019 were selected as the research subjects, and they were grouped according to the random number table method. The 23 patients in the reference group were treated with Azithromycin, and the 23 patients in the study group were treated with Azithromycin combined with Methylprednisolone. Serum inflammatory factors such as high-sensitivity C-reactive protein (hs-CRP), serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6),as well as the total number of T lymphocytes (CD3+), negative T cells (CD4+), positive T cells (CD8+) and the ratio of negative T cells to positive T cells (CD4+/CD8+) peripheral blood indexes were compared and analyzed, and the clinical efficacy of the two groups was observed. Results After treatment, the levels of hs-CRP, TNF-α and IL-6 in the two groups were lower than those in this group before treatment, and the differences were statistically significant (P<0.05).The levels of hs-CRP, TNF-α and IL-6 in the study group were lower than those in the reference group after treatment, the differences were statistically significant (P<0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+of the two groups were higher than those in this group before treatment, and the level of CD8+ was lower than that in this group before treatment, the differences were statistically significant (P<0.05). After treatment, the levels of CD3+, CD4+,CD4+/CD8+in the study group were higher than those in the reference group, and the level of CD8+ was lower than that in the reference group, the differences were statistically significant (P<0.05). The total effective rate of treatment in the study group was higher than that in the reference group, the difference was statistically significant (P<0.05). Conclusion The effect of Azithromycin combined with Methylprednisolone in the treatment of refractory Mycoplasma pneumonia has been fully demonstrated, which can improve the clinical symptoms of patients and reduce inflammation, and has high clinical application value.

Objective To investigate the effect of Inhaled Budesonide Suspension combined with Terbutaline Sulfate Solution for Nebulization in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 88 cases of patients with acute exacerbation of chronic obstructive pulmonary disease treated in our hospital from January to December 2019 were selected as the research objects, and divided into the observation group and the reference group by even and odd grouping method, with 44 cases in each group. The reference group was treated with Inhaled Budesonide Suspension, and the observation group was treated with Terbutaline Sulfate Solution for Nebulization on the basis of the reference group. The clinical efficacy, lung function indexes and serum indexes before and after treatment were compared between the two groups. Results The total effective rate of treatment of the observation group was higher than that of the reference group, and the difference was statistically significant (P<0.05). The forced expiratory volume in the first second (FEV1), forced vital capacity (FVC) and the ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) after treatment in two groups were higher than those before treatment, and the FEV1, FVC and FEV1/FVC in observation group were higher than those in the reference group, and the differences were statistically significant (P<0.05). The procalcitonin (PCT), interleukin-6 (IL-6), and interferon-γ (IFN-γ) after treatment in the two groups were lower than those before treatment, and the PCT, IL-6, and IFN-γ in the observation group were lower than those in the reference group, and the differences were statistically significant (P<0.05). Conclusion Patients with acute exacerbation of chronic obstructive pulmonary disease receive Inhaled Budesonide Suspension combined with Terbutaline Sulfate Solution for Nebulization can significantly improve patients′ lung function and serum indicators, improve the treatment effect of the disease, and have higher application value.

Objective To explore the effect of Rupixiao Tablets combined with Sanjie Rupi Ointment in the treatment of breast hyperplasia. Methods A total of 70 patients with breast hyperplasia admitted to our hospital from April to September 2019 were selected as the research objects, and they were divided into control group (35 cases) and observation group (35 cases) according to the random paper method. The control group was treated with Rupixiao Tablets,and the observation group was treated with Rupixiao Tablets combined with Sanjie Rupi Ointment. The visual analogue score, quality of life score, clinical efficacy, breast lumps elimination time and breast pain disappearance time were compared between the two groups. Results There were no significant differences in visual analogue score and quality of life score between the two groups before treatment (P>0.05). The visual analogue scores in the control group and the observation group after treatment ([5.2±1.1]and [4.0±0.8]points) were lower than those before treatment ([6.7±1.5]and[6.4±1.7]points), quality of life scores ([78.4±9.2]points and [88.7±8.8]points) were higher than those before treatment([67.8±10.2]and [66.4±9.9]points), the differences were statistically significant (P<0.05). The visual analogue score in the observation group after treatment was lower than that in the control group, and the quality of life score was higher than that in the control group, the differences were statistically significant (P<0.05). The total effective rate of clinical treatment in the observation group (97.1%) was higher than that in the control group (85.7%), the breast lumps elimination time in the observation group ([2.6±0.8]d) and the breast pain disappearance time ([2.0±0.9]d) were shorter than those in the control group ([4.2±1.4]d and [3.7±1.1]d), the differences were statistically significant (P<0.05). Conclusion Rupixiao Tablets combined with Sanjie Rupi Ointment in the treatment of patients with breast hyperplasia has significantly reduced pain, improved quality of life and clinical effect, shortened the time for improvement of clinical symptoms, and is worthy of clinical application.

Objective To investigate the effect of Sitagliptin combined with Insulin Glargine on blood glucose, serum leptin and insulin resistance in patients with type 2 diabetes mellitus. Methods A total of 72 patients with type 2 diabetes mellitus who were admitted to the Third Affiliated Hospital of Nanchang University from March 2018 to December 2019 were selected as the research objects and divided into the control group and the observation group according to the random number table method, with 36 cases in each group. The control group was given subcutaneous injection of Insulin Glargine, and the observation group was treated with Sitagliptin based on the control group, with 2 months of treatment in two groups. The blood glucose, serum leptin levels, pancreatic function before and after treatment and incidence of adverse reactions in the two groups were observed. Results After treatment for 2 months, the levels of glucose metabolism indexes, serum leptin, fasting insulin (FINS) and homeostasis model assessment of insulin resistance(HOMA-IR) in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). The total incidence rate of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Sitagliptin combined with Insulin Glargine in the treatment of patients with type 2 diabetes mellitus can decrease the levels of blood glucose and serum leptin, improve insulin resistance,and reduce the incidence of adverse reactions, which has better curative effect.

Objective To explore the clinical effect of combined treatment with Sitagliptin when blood glucose is poorly controlled with Metformin alone. Methods A total of 105 patients with type 2 diabetes mellitus who were treated in our hospital from January 2017 to October 2019 were selected as the research objects, 5 cases fell out and 100 cases were eventually enrolled. They were divided into three groups by the random number table method, namely Metformin alone group (group A, n=30), Metformin+Acarbose group (group B, n=35), and Metformin+Sitagliptin group (group C, n=35).The glycated hemoglobin (HbA1c), 1,5-anhydroglucose (1,5-AG), malondialdehyde (MDA), stromal cell-derived factor-1α (SDF-1α) before and after treatment were compared among the three groups, and the incidence of adverse reactions was recorded in the three groups. Results After treatment, the HbA1c and MDA in group B and C were lower than those in group A, and the differences were statistically significant (P<0.01). There were no significant differences in HbA1c and MDA between group B and group C after treatment (P>0.05). The 1,5-AG in group B and C was higher than that in group A at different visit periods after treatment, and the difference was statistically significant (P<0.05).The 1,5-AG in group C was higher than that in group B in visit period 2 and visit period 3, and the difference was statistically significant (P<0.05). There was no significant difference in SDF-1α in group A and group B before and after treatment (P>0.05). The SDF-1α in group C after treatment was higher than that before treatment and in group A and group B, and the difference was statistically significant (P<0.01). The total incidence of adverse reactions in group A and group C was lower than that in group B, and the difference was statistically significant (P<0.05). Conclusion When blood glucose is poorly controlled with Metformin alone, the combination of Sitagliptin or Acarbose both can reduce the level of HbA1c in a tantamount effect; however, the combination of Sitagliptin has smaller blood glucose fluctuations and can reduce oxidative stress and cellular damage, and can improve atherosclerosis, which is an optimal glucoselowering program.

Objective To investigate the influence of Metformin combined with acupuncture on glucolipid metabolism and adipokines in obese polycystic ovarian syndrome (PCOS). Methods A total of 90 patients with obese PCOS who admitted in our hospital from February 2018 to February 2019 were selected as the research subjects. All selected cases were divided into group A(30 cases),group B(30 cases)and group C(30 cases)according to random number table method.Group A was treated with Metformin, group B was treated with acupuncture, and group C was treated with Metformin combined with acupuncture. The levels of sex hormones, glucolipid metabolism indexes, adipokines levels and pregnancy rates were compared among the three groups. Results After treatment, the levels of triglyceride (TG), follicle-stimulating hormone (FSH) and testosterone (T) in group C were lower than those in group A and group B, and the level of estradiol (E2) in group C after treatment was higher than that in group A and group B, the differences were statistically significant (P＜0.05). After treatment, the triglyceride (TG), fasting plasma glucose (FPG) and homeostasis model assessment of insulin resistance (HOMA-IR) in group C were lower than those in group A and group B, the differences were statistically significant (P＜0.05). After treatment, the body mass index (BMI) and waist-hip ratio in group C were lower than those in group A and group B, the differences were statistically significant (P＜0.05). The pregnancy rate of group C was higher than that of group A and group B, the difference was statistically significant (P＜0.05). Conclusion Metformin combined with acupuncture in the treatment of obese PCOS patients can decrease BMI, improve the level of insulin and glucolipid metabolism, regulate the levels of sex hormones, and promote the pregnancy.

Objective To investigate the clinical effect of early nasal continuous positive airway pressure (NCPAP) in improving the prognosis of respiratory distress syndrome (NRDS) in premature infants within 34 weeks. Methods A total of 86 premature infants with NRDS treated in our hospital from March 2018 to November 2019 were selected as the research objects,and they were divided into control group(43 cases)and observation group(43 cases)according to the random number table method. The control group was treated with Ambroxol, and the observation group was treated with Ambroxol and early NCPAP. The results of blood gas analysis, treatment and complications were compared between the two groups at different time points. Results The blood power of hydrogen (pH) and oxygenation index (OI) in observation group were higher than those in control group, the arterial partial pressure of carbon dioxide (PaCO2), ratio of mechanical ventilation and the total incidence of complications in observation group were lower than those in control group, and the time of oxygen therapy and hospitalization time in observation group were shorter than those in control group, the differences were statistically significant (P<0.05). Conclusion Early NCPAP in adjuvant treatment of NRDS has better effect, it can improve blood gas indexes, decrease the ratio of mechanical ventilation, shorten the treatment time of children, reduce the incidence of complications and promotes recovery of premature infants, which is worthy of promotion.

Objective To investigate the clinical significance of the changes of T lymphocyte immunity and cytokines in children with primary nephrotic syndrome (PNS). Methods A total of 30 children with PNS admitted to our hospital from June 2015 to March 2019 were selected as the research objects and divided into active group (13 cases) and remission group (17 cases) according to disease progression. Meanwhile, 30 healthy children were selected as the control group. The levels of CD3+, cytotoxic T cell (Tc), helper T cell (Th), Th/Tc and interleukin-6 (IL-6) in the three groups were compared. Results There was no statistically significant difference in CD3+level among the three groups (P>0.05).Th and Th/Tc levels in the active group and the remission group were lower than those in the control group, and the differences were statistically significant (P<0.05). Tc and IL-6 levels in the active group and the remission group were higher than those in the control group, and the differences were statistically significant (P<0.05). Th and Th/Tc levels in the active group were lower than those in the remission group, and the differences were statistically significant (P<0.05). Tc and IL-6 levels in the active group were higher than those in the remission group, and the differences were statistically significant (P<0.05). IL-6 was positively correlated with Tc (r=0.91, P<0.01), negatively correlated with Th(r=-0.92, P<0.05) and negatively correlated with Th/TC (r=-0.90, P<0.05). Conclusion There are changes in T lymphocyte subsets and cytokines in children with PNS, which may play a role in the pathogenesis of PNS.

Objective To investigate the clinical effect of Tanreqing Injection in treatment of fever children with cough and expectoration. Methods A total of 120 fever children with cough and expectoration admitted in our hospital from June 2018 to December 2019 were selected as research subjects and divided into control group and experimental group according to random number table method, with 60 cases in each group. The control group was treated with routine antiviral drugs, and the experimental group was treated with routine antiviral drugs and Tanreqing Injection. The clinical efficacy, relief time of expectoration, relief time of cough, recovery time of temperature, C-reactive protein (CRP), white blood cell count (WBC) and neutrophil ratio were compared between the two groups. Results The total effective rate of experimental group was higher than that of control group, and the difference was statistically significant (P<0.05). The relief time of expectoration, relief time of cough and recovery time of temperature in experimental group were shorter than those in control group, and the differences were statistically significant (P<0.05). The levels of CRP, WBC and neutrophil ratio in two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). The levels of CRP, WBC and neutrophil ratio in experimental group after treatment were lower than those in control group, and the differences were statistically significant (P<0.05). Conclusion Tanreqing Injection in treatment of fever children with cough and expectoration has good effects, it can shorten relief time of clinical symptoms, decrease the levels of inflammatory factors, relieve the symptoms of fever and cough.

Objective To investigate the clinical effect of pelvic floor functional magnetic stimulation combined with Kegel exercise in the treatment of postpartum stress urinary incontinence (SUI). Methods A total of 136 cases of postpartum mild to moderate SUI patients in our hospital from July 2018 to June 2019 were selected as the research objects and divided into the study group and the control group according to the random number table method, with 68 cases in each group. The study group received pelvic floor functional magnetic stimulation (twice a week) combined with Kegel exercise (2 months), while the control group received Kegel exercise (2 months). The improvement of pelvic floor muscle strength and the clinical effect and recurrence of urinary incontinence were compared between the two groups. Results The normal rate of pelvic floor muscle strength in the study group was higher than that in the control group, and the difference was statistically significant (P<0.05). The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). The recurrence rates of the study group at 3 and 6 months after treatment were lower than those of the control group, and the differences were statistically significant (P<0.05). Conclusion Pelvic floor functional magnetic stimulation combined with Kegel exercise can significantly improve the pelvic floor muscle strength of postpartum mild and moderate SUI, relieve the symptoms of urinary incontinence, with less adverse reactions and low recurrence rate, which is worthy of clinical promotion and application.

Objective To explore the application effect of tea tree oil on neonatal red buttocks. Methods From January 2018 to May 2019, 200 neonates with red buttocks in our hospital were selected as the research objects, they were divided into the control group and the observation group according to the random number table method, with 100 cases in each group. The control group used traditional method to wash the newborn′s buttocks with warm water, keep them clean and dry and apply Zinc Oxide Ointment locally; the observation group used warm water to wash the newborn′s buttocks, keep them clean and dry and apply tea tree oil locally. The red buttocks disappearance time, intervention effectiveness and skin lesion score of the two groups of newborns were compared and analyzed. Results After the end of 1 week of intervention, the total effective rate in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). The time to fade of mild, moderate and severe red buttocks in the observation group was shorter than that in the control group, the differences were statistically significant (P<0.05). There was no significant difference in skin lesion scores between the two groups before intervention (P>0.05); after the end of 1 week of intervention, the skin lesion scores in the two groups were lower than those before intervention, and the observation group was lower than that in the control group, the differences were statistically significant (P<0.05). Conclusion The use of tea tree oil in neonatal red buttocks has a better effect and can effectively improve the clinical efficacy of neonatal red buttocks, shorten the time for the regression of mild, moderate and severe red buttocks, and reduce the score of buttocks.

Objective To explore the effect of different initial concentration oxygen resuscitation programs on the rescue of full-term neonatal asphyxia. Methods The clinical data of 60 cases of full-term neonatal asphyxia who received treatment in our hospital from July 2018 to December 2019 were selected, and they were divided into control group and observation group according to the difference of initial concentration oxygen resuscitation, with 30 cases in each group. The control group received resuscitation treatment with 21% oxygen concentration, and the observation group received resuscitation treatment with 30% oxygen concentration. The first crying time, spontaneous breathing time, heart rate at 5 min of resuscitation, oxygen resuscitation rate, brain injury rate, success rate of resuscitation,incidence of oxygen poisoning, and the newborn Apgar scores at 1, 5 and 10 min after treatment were compared between the two groups. Results There were no significant differences in the incidence of brain injury, the success rate of resuscitation and the heart rate at 5 min of resuscitation between the two groups (P>0.05). The oxygen resuscitation rate (3.33%) and the incidence of oxygen poisoning (0.00%) in the observation group were lower than those in the control group (26.66%, 20.00%), the differences were statistically significant (P<0.05). The first crying time and spontaneous breathing time in the observation group were shorter than those in the control group, with statistically significant differences (P<0.05). There was no significant difference in Apgar score at 1 min between the two groups(P>0.05), while the Apgar scores at 5 and 10 min in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion For the rescue treatment effect of full-term neonatal asphyxia, the 30% oxygen concentration resuscitation treatment and 21% oxygen concentration resuscitation treatment has the same effect and is safe and reliable, but 30% oxygen concentration resuscitation treatment can effectively reduce the rate of brain injury in patients, shorten the time of spontaneous breathing and first crying, and improve Apgar score, which is worthy of clinical application.

Objective To explore the influence of Mycoplasma pneumoniae (MP) infection on the treatment effect and prognosis of children with idiopathic thrombocytopenic purpura (ITP). Methods A total of 78 children with ITP treated in our hospital from January 2016 to June 2019 were selected. They were divided into MP-negative group (48 cases)and MP-positive group (30 cases) according to MP infection. The selected children all received conventional ITP treatment such as Prednisone and symptomatic support for hemostasis. The clinical efficacy, clinical indicators, inflammatory factor, immune function indicators and recurrence rate of the two groups were recorded and observed. Results The total effective rate in treatment in the MP-positive group was 70.00%, lower than that in the MP-negative group of 91.67%, and the recurrence rate in the MP-positive group was 33.33%, higher than that in the MP-negative group of 8.33%, the differences were statistically significant (P<0.05). In the MP-positive group, the hospital stay and rash subsided time were (15.68±0.71) d and (10.49±1.53) d, longer than those in the MP-negative group of (11.27±0.59) d and(8.31±1.04) d, the differences were statistically significant (P<0.05). In the MP-positive group, the interleukin-6 (IL-6),interleukin-17 (IL-17) and CD8+ were (23.28±2.34) pg/ml, (70.19±12.28) pg/ml and (42.37±7.61)%, higher than those in the MP-negative group of (16.32±1.65) pg/ml, (58.67±10.51) pg/ml, and (35.97±6.50 )%, CD4+/CD8+ and natural killer (NK) cells (16++56+) were (1.03±0.42)% and (6.91±0.58)%, lower than those in the MP-negative group of (1.67±0.63)% and (11.08±1.52)%, the differences were statistically significant (P<0.05). Conclusion The inflammatory response of ITP children with MP infection is aggravated and there is immune dysfunction. The conventional treatment is not effective, and scientific and reasonable treatment for the etiology is needed to enhance the therapeutic effect of ITP and improve the prognosis.

Objective To investigate the clinical effect of Azithromycin combined with Jingangteng Capsules and Baofukang Suppository in the treatment of Chlamydia trachomatis vagina cervicitis. Methods A total of 272 patients with Chlamydia trachomatis vagina cervicitis treated in departmemt of dermatology and gynecology clinic of traditional Chinese medicine of our hospital from January 2013 to November 2018 were selected as the research subjects and divided into the treatment group (157 cases) and the control group (115 cases) by randomized and double-blind method. The treatment group was given Azithromycin Tablets and Jingangteng Capsules for oral administration, and Baofukang Suppository was given to the vagina. The control group was given Azithromycin Tablets alone. The drug was administered continuously for 2 weeks and rechecked 1 week after the drug was stopped. The efficacy, changes in symptoms and signs, symptom score were compared between the two groups. Results The total effective rate in the treatment group(86.6%) was higher than that in the control group (72.2%), and the difference was statistically significant (P<0.01). The improvement of symptoms and signs, such as pathogen, increased secretion, and abnormal cleanliness in the treatment group were superior than those in the control group, and the differences were statistically significant (P<0.05). The symptom score of the treatment group was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion The therapeutic effect of Azithromycin combined with Jingangteng Capsules and Baofukang Suppositoryon in the treatment of Chlamydia trachomatis vaginal cervicitis is better than that of Azithromycin alone and can be used as a clinical treatment for Chlamydia trachomatis vaginal cervicitis.

Objective To explore the effect of doula company delivery on improving delivery quality of parturient.Methods A total of 200 parturients delivered in our hospital from January 2015 to January 2016 were selected as the research objects and randomly divided into control group and observation group with 100 cases in each group. The control group was treated with routine nursing and the observation group was treated with doula company delivery. The delivery mode of parturients, fetal distress, neonatal asphyxia and maternal pain were compared between the two groups. Results The natural delivery rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). There were no statistically significant differences in the incidence of fetal distress and the total incidence of neonatal asphyxia between the two groups (P>0.05). The pain score of the observation group was (2.21±0.64) points, which was lower than that of the control group of (3.18±0.57) points, and the difference was statistically significant (P<0.05). Conclusion The doula company can improve the quality of delivery, reduce the pain of delivery, reduce cesarean sections and improve the rate of natural delivery. It is worthy of clinical promotion and application.

Objective To explore the application of axillary vein indwelling needle technique in premature infant of neonatal intensive care unit (NICU). Methods A total of 110 cases of NICU premature infants admitted to our hospital from June to December 2019 were selected as the research objects, they were divided into study group and control group using random number table method, 55 cases in each group. The study group received intravenous indwelling trocar infusion, and the control group received intravenous infusion of extremities and scalp. The effect of needle placement, indwelling time and the incidence of related complications were compared between the two groups. Results The success rate of first needle puncture in the study group was higher than that in the control group, the puncture time was shorter than that in the control group, the unplanned extubation rate was lower than that in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the accidental drop-off rate of the indwelling needle between the two groups (P＞0.05). The proportion of indwelling needle retention time>72 h in the study group was higher than that in the control group, and the indwelling time was longer than that in the control group,the differences were statistically significant (P＜0.05). The total incidence of complications in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The technique of axillary vein indwelling needle can effectively improve the effect of NICU neonates and reduce the incidence of complications,it is worthy of further clinical application.

Objective To compare the effect between direct filling with SDR resin inlay and indirect repair of Ceramage polymerization ceramic inlay on microleakage of wedge-shaped defects. Methods A total of 50 mandibular first premolars were collected to establish wedge-shaped defect model group, and they were randomly divided into group A(25 teeth) and group B (25 teeth). Group A was directly filled with SDR resin inlay, while group B was given indirect repair of Ceramage polymerization ceramic inlay. After immersion fatigue and thermal cycling aging, the microleakage depth of dye along the occlusal wall and gingival wall was measured by dye penetration method under stereomicroscope, the degree of microleakage was compared between the two groups. Results Microleakage was found between the occlusal wall and gingival wall of the two groups. The marginal microleakage of the occlusal side wall in group A was less than that of the gingival side wall, the difference was statistically significant (P＜0.05). In group B, there was no significant difference in the marginal microleakage between the occlusal side wall and the gingival side wall (P＞0.05).The microleakage depth of occlusal wall and gingival wall in group B were less than those in group A, the differences were statistically significant (P＜0.05). Conclusion The marginal seal of wedge-shaped defects with Ceramage polymerization ceramic inlay is superior to direct filling with SDR resin inlay.

Objective To analyze the clinical effect of middle ear surgery under otoscope in the treatment of otitis media. Methods A total of 40 patients with otitis media treated in our hospital from January 2018 to January 2019 were selected as the research objects. They were divided into the observation group (20 cases) and the control group (20 cases) according to the computer random allocation method. The observation group was given middle ear surgery, the control group used conventional treatment. The total effective rate, the total incidence rate of complication, and recurrence rate were compared between the two groups. Results The total effective rate of patients in the observation group was 95.00%, which was higher than 55.00% in the control group (P＜0.05). The total incidence rate of complications in the observation group was 5.00%, which was lower than 30.00% in the control group (P＜0.05). The recurrence rate of patients in the observation group was 10.00%, which was lower than 35.00% in the control group (P＜0.05). Conclusion The clinical effect of middle ear surgery under otoscope in the treatment of otitis media is significant, with high safety and low recurrence rate.

Objective To explore the clinical effect of minimally invasive technique on impacted teeth extraction.Methods A total of 80 patients with impacted teeth admitted to our hospital from January 2019 to February 2020 were selected as the research subjects and divided into two groups by odd or even number, with 40 cases in each group. Patients in the control group were treated with traditional tooth extraction. Patients in the observation group were treated with minimally invasive. After treatment, the visual analogue scale (VAS), alveolar socket integrity, operation time, incomplete extraction socket, satisfaction, oral health impact profile (OHIP-14) scale and complications were compared between the two groups. Results After treatment, the VAS score ([1.12±0.22]points), alveolar socket integrity score([1.05±0.33]points), the incidence of incomplete extraction socket (2.50%), physiological pain ([1.45±0.19]points), social disorder ([1.19±0.22]points), functional limitation ([2.39±0.42]points), physical disorder ([2.05±0.16]points) and total incidence of complication (2.50%) in the observation group were all lower than those of the control group ([2.65±0.43]points, [2.76±0.41]points, 20.00%, [2.86±0.57]points, [3.46±0.75]points, [4.85±0.61]points, [3.58±0.43]points,27.50%), and the differences were statistically significant (P<0.05). The operation time of the observation group([34.84±3.56]min) was shorter than that of the control group ([47.76±4.23]min), and the difference was statistically significant (P<0.05). The satisfaction of the observation group (100.00%) was higher than that of the control group(80.00%), and the difference was statistically significant (P<0.05). Conclusion In the extraction of impacted teeth, the effect of minimally invasive treatment is better than the traditional tooth extraction.

Objective To explore the application effect of root canal microscopy combined with ultrasound in the treatment of dental pulp. Methods From February 2017 to February 2019, 93 patients with dental pulp disease treated in our hospital were selected as the research subjects. They were divided into the reference group (n=46) and the study group (n=47) according to the random digital table method. The patients in the control group were treated with root canal therapy in a routine way, while the patients in the study group were treated with root canal microscope combined with ultrasound. The operative time and anaesthesia time of the two groups were recorded, the clinical effect and the adverse reactions of the two groups were compared. Results The operation time, the anaesthesia time of the patients in the study group were longer than those in the control group, the differences were statistically significant (P＜0.05). The total effective rate of treatment in the study group was 91.49%, which was higher than that in the control group(91.49%), the difference was statistically significant (P＜0.05). The total incidence of adverse reactions in the study group was 6.38%, which was lower than 26.09% in the reference group, and the difference was statistically significant(P＜0.05). Conclusion Compared with common root canal therapy, root canal microscopy combined with ultrasound in the treatment of dental pulp disease is more effective, and the incidence of complications is lower, but the treatment time is longer.

Objective To compare the application effect of hospital multimedia training and family training in amblyopia children. Methods A total of 92 amblyopic children (163 eyes) in our hospital from October 2018 to October 2019 were selected as research subjects and divided into observation group (47 cases, 84 eyes) and control group (45 cases,79 eyes) by random number table method. Children in observation group were treated by covering therapy combined with hospital multimedia training. Children in control group were treated by covering therapy combined with family training. After 3 months, the corrected visual acuity was reexamined and the therapeutic effect were compared between the two groups. Results The total effective rates of treatment of aged 3-6 and >6-12 children in observation group were higher than those in control group, and the differences were statistically significant (P<0.05). The total effective rates of treatment of ametropic amblyopia and anisometropic amblyopia in observation group were higher than those in control group, and the differences were statistically significant (P<0.05). There was no difference in the total effective rate of treatment of strabismic amblyopia between two groups (P>0.05). There was no difference in the total effective rate of treatment of mild amblyopia between two groups (P>0.05). The total effective rates of treatment of moderate and severe amblyopia were higher than those in control group, and the differences were statistically significant (P<0.05).Conclusion The treatment effect of hospital multimedia training is better than family training in treating amblyopia, especially for ametropic and anisometropic amblyopia, and moderate to severe amblyopia.

Objective To explore the effect of digital impression on zirconia single crown restoration in esthetic zone.Methods A total of 100 patients with zirconia single crown restoration in the esthetic zone admitted to the Affiliated Shunde Hospital of Guangzhou Medical University from January 2015 to December 2018 were selected as the research objects and divided into control group and observation group according to random number table method, with 50 cases in each group. The impressions of the observation group were made by digital impression technique. The impressions of the control group were made with silicone rubber by two-step method. The qualities of crowns, the treatment time and the gingival recession rate of abutments were compared between the two groups. Results The marginal adaptation of crowns in the observation group was better than that in the control group, and the difference was statistically significant(P<0.05). There were no significant differences in the shape accuracy, surface texture and color between the crowns of two groups (P>0.05). The treatment time of the observation group was shorter than that of the control group, and the difference was statistically significant (P<0.05). The gingival recession rate of abutments in the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion In the zirconia single crown restoration in esthetic zone, the application of digital impression is effective in improving the marginal adaptation of crowns, saving treatment time and reducing the gingival recession rate of abutments, which is worthy of popularization and application.

Objective To explore the diagnostic value of cervical vascular ultrasound in cerebral infarction with carotid stenosis. Methods A total of 80 patients with cerebral infarction and carotid stenosis who were treated in Xingguo County People′s Hospital from January 2019 to January 2020 were selected as the research subjects. The patients were given digital subtraction angiography and carotid vascular ultrasound examination. Using digital subtraction angiography as the gold standard, the detection of atherosclerosis and plaque by carotid vascular ultrasound examination was compared, and the sensitivity, specificity and accuracy of carotid artery ultrasound in the diagnosis of mild, moderate, severe stenosis and occlusive vessels were evaluated. Results There was no significant difference in the detection rate of atherosclerosis and plaque between carotid vascular ultrasound and digital subtraction angiography (P＞0.05). Among the stenosis detected by digital subtraction angiography, 114 cases of carotid arteries were detected in 80 patients, including 22 cases with mild stenosis, 21 cases with moderate stenosis, 21 cases with severe stenosis and 22 cases with complete occlusion. Carotid artery ultrasound examination showed 16 cases were mild stenosis, 13 cases were moderate stenosis, 20 cases were severe stenosis, and 22 cases were complete occlusion. The sensitivity of carotid artery ultrasound in the diagnosis of mild stenosis, moderate stenosis, severe stenosis and complete occlusion were 63.64%,57.14%, 85.71%, 90.91%, respectively, the specificity were 97.83%, 98.92%, 97.85%, 97.83%, and the accuracy were 91.23%, 91.23%, 95.61% and 96.49%, all over 90%. Conclusion The application of cervical vascular ultrasound in the diagnosis of cerebral infarction combined with carotid stenosis is of high clinical value, with high specificity and accuracy. It can effectively judge the degree of carotid stenosis and the occlusion of cerebral infarction, which is conducive to the examination of high-risk group of cerebral infarction combined with carotid stenosis.

Objective To investigate the application value of multi-slice spiral CT in the diagnosis of chronic obstructive pulmonary disease (COPD). Methods A total of 120 cases of patients with chronic obstructive pulmonary disease who were admitted in the hospital from January 2018 to December 2019 were selected as the subjects. All the patients were divided into the mild group (n=36), the moderate group (n=30), the moderate-severe group (n=24), the severe group (n=18) and the extremely severe group (n=12) according to results of forced expiratory volume in one second prediction (FEV1%). The five groups were diagnosed by multi-slice spiral CT. The detection rate of multi-slice spiral CT for different degrees of disease and the cross-sectional area of pulmonary small vessels in the five groups were compared. Results A total of 22 patients with mild chronic obstructive pulmonary disease were detected by multi-slice spiral CT, with the detection rate of 61.11% (22/36). A total of 21 patients with moderate chronic obstructive pulmonary disease were detected, with the detection rate of 70.00% (21/30). A total of 17 patients with moderate-severe chronic obstructive pulmonary disease were detected, with the detection rate of 70.83% (17/24). A total of 14 patients with severe chronic obstructive pulmonary disease were detected, with the detection rate of 77.78% (14/18). A total of 11 patients with extremely severe chronic obstructive pulmonary disease were detected, with the detection rate of 91.67%(11/12). The blood vessel/lung cross-sectional area of sub-segment level and below (%CSA<5) and blood vessel/lung cross-sectional area of CSA sub-segment level (%CSA 5-10) in the extremely severe group were lower than those in the severe group, the differences were statistically significant (P<0.05). The blood vessel/lung cross-sectional area of sub-segment level and below (%CSA<5) and blood vessel/lung cross-sectional area of CSA sub-segment level (%CSA 5-10) in the severe group were lower than those in the moderate-severe group, the differences were statistically significant (P<0.05). The blood vessel/lung cross-sectional area of sub-segment level and below (%CSA<5)and blood vessel/lung cross-sectional area of CSA sub-segment level (%CSA 5-10) in the moderate-severe group were lower than those in the moderate group, the differences were statistically significant (P<0.05). The blood vessel/lung cross-sectional area of sub-segment level and below (%CSA<5) and blood vessel/lung cross-sectional area of CSA sub-segment level (%CSA 5-10) in the moderate group were lower than those in the mild group, the differences were statistically significant (P<0.05). Conclusion Multi-slice spiral CT in the diagnosis of chronic obstructive pulmonary disease has better effects, it can objectively evaluate the severity of the condition. The more severe the condition of patients, the smaller the area of pulmonary small vessels.

Objective To analyze the 3.0T magnetic resonance dynamic enhancement characteristics of breast cancer patients. Methods A total of 50 cases of breast cancer admitted to our hospital from January 2015 to August 2019 were selected as the research subjects. Magnetic resonance imaging (MRI) was performed, the changes of adjacent structures,morphology, MRI signal, enhancement mode and time signal intensity curve were observed, indicators for early diagnosis of breast cancer were screened out. Results There were 68% (34/50) breast cancer patients with irregular shape of tumor, and 32% (16/50) breast cancer patients with round shape tumors. There were 80% (40/50) patients with "spiculation sign" on the edge, and 58% (29/50) patients with Cooper ligament (breast suspension ligament). Among the lesions, 54% (27/50) patients had sand like calcification, 44% (22/50) patients had local skin thickening, and 18% (9/50)patients with nipple collapse. 76% (38/50) patients had a circular strengthening, and 26% (13/50) patients had contrast filling signs. 68% (34/50) patients showed fast-forward and fast-out curve, 24% (12/50) patients showed plateaushaped curve, and 8% (4/50) patients showed slowly rising curve. Conclusion Multi parameter comprehensive evaluation of various indexes in dynamic contrast-enhanced MRI can be used as an important reference factor in the diagnosis of breast cancer, which is helpful to the early diagnosis of breast cancer.

Objective To observe the clinical value of multi-slice spiral CT (MSCT) in the diagnosis of gastric cancer.Methods The clinical data of 200 patients with gastric cancer diagnosed by pathology from February 1, 2015 to May 10, 2016 in our hospital were retrospectively analyzed, and they were divided into the observation group and the control group according to different examination methods, with 100 cases in each group. The observation group was diagnosed with MSCT, and the control group was examined with electronic gastroscopy. The detection rate, missed diagnosis rate,pathological stage detection rate, and inspection time of the two groups were compared. Results The detection rate of the observation group was higher than that of the control group, and the missed diagnosis rate of the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05). The detection rate of pathological stages in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). The observation time of the observation group was shorter than that of the control group, the difference was statistically significant (P＜0.05). Conclusion The implementation of MSCT in the diagnosis of gastric cancer patients can improve the diagnostic coincidence rate and reduce the missed diagnosis rate, which is worthy of promotion and application in clinical practice.

Objective To explore the applications of color Doppler echocardiography in left ventricular hypertrophy due to hypertension with left heart failure. Methods A total of 60 cases left ventricular hypertrophy due to hypertension with left heart failure patients in People Hospital of Xinyu City in Jiangxi Province from February 2016 to February 2019 were selected as the observation group, according to different grades of cardiac function, 26 cases were classified as grade Ⅱ, 30 cases as grade Ⅲand 4 cases as grade Ⅳ. Another 50 healthy individuals in the same period were selected as the control group. The left atrial diameter (LAD), left ventricular posterior wall thickness (LVPWT), left ventricular end diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), E value, A value and E/A value of the two group of study object, different cardiac function patients were observed. Results The LAD, LVPWT, LVEDD, A value of the observation group were higher than those of the control group, the LVEF, E value, E/A value of the observation group were lower than those of the control group, the differences were statistical significance (P＜0.05). The LAD、LVPWT、LVEDD、A value of cardiac function grade Ⅱpatients were lower than those of grade Ⅲ, grade Ⅳpatients, the LVEF, E, E/A value of cardiac function grade Ⅱpatients were higher than those of grade Ⅲ, grade Ⅳpatients, the differences were statistical significance (P ＜0.05). There was no significant difference in LAD, LVPWT,LVEDD, LVEF, E value, A value and E/A value between grade Ⅲpatients and grade Ⅳpatients (P＞0.05). Conclusion The color doppler echocardiography detection could effective evaluate cardiac function of patients on left ventricular hypertrophy due to hypertension with left heart failure, which can determine cardiac function classification, and provide theoretical basis for guiding clinical treatment.

Objective To explore the current status of female infertility patients′ reproductive life quality and its influencing factors. Methods Convenience sampling was used to select 423 female infertility patients who were diagnosed from July to November 2019. The general information questionnaire, self-esteem scale, reproductive quality of life scale and comprehension social support scale were used for investigation and analysis, and multiple linear stepwise regression analysis was used to screen out the factors affecting the quality of life of female infertility patients. Results The score of quality of life of female infertility patients was (59.37±14.67) points. The results of multiple linear stepwise regression analysis showed that understanding social support and self-esteem were protective factors for the quality of reproductive life, and feelings of discrimination (P＜0.05), stigma and husbands as the only child were risk factors for the quality of reproductive life (P＜0.05). Finally, the adjusted R2 was 31.6%. Conclusion The quality of reproductive life of female infertility patients is at a medium level. Nursing staff should actively play the role of understanding social support and self-esteem, and adopt psychological interventions to improve the quality of reproductive life of female infertility patients.

Objective To investigate the application effect of SBAR communication model in bedside handover in neonatal intensive care unit (NICU). Methods A total of 150 times of night shift and day shift nurses for bedside handover in NICU of Department of Gynaecology and Obstetrics in Yichun Maternal and Child Health Hospital from January to March 2019 were selected as control group, accepted traditional handover mode; 150 times of night shift and day shift nurses for bedside handover from April to June 2019 were selected as observation group, accepted bedside handover based on SBAR communication model. The complete rate of handover contents, total incidence of adverse events and total satisfaction of medical staff were compared between two groups. Results The complete rate of handover contents in observation group was higher than that in control group, the difference was statistically significant (P<0.05);the total incidence of adverse events in observation group was lower than that in control group, the difference was statistically significant (P<0.05); the total satisfaction of medical staff in observation group was higher than that in control group, the difference was statistically significant (P<0.05). Conclusion SBAR communication mode can improve the complete rate of NICU handover, reduce the incidence of adverse events, and improve the satisfaction of medical staff.It is worthy of clinical application.

Objective To explore the application of mobile internet in recruitment of component blood loss donors.Methods A total of 1200 people who had a history of component blood donation at the Chongqing Blood Center from June 2016 to June 2017 were selected as the subjects of this study. According to their ID numbers, they were randomly divided into control group and observation group, with 600 people in each group. The control group was recruited by telephone, and the observation group was recruited by mobile internet. Recruitment time was one year. At the end, the blood donation rate of the two groups was counted, and the reasons for the loss and the failure of re-recruitment of the two groups were counted through questionnaire survey. Results The observation group successfully recruited 392 people, the recruitment success rate was 65.33%, and the blood donation rate was 59.17%; the control group recruited 276 people successfully, the recruitment success rate was 46.00%, and the blood donation rate was 40.17%, the recruitment success rate and the blood donation rate were higher than those of the control group, and the differences were statistically significant(P＜0.05).Failure-related factors:the observation team′s communication time was inappropriate,the communication location was not appropriate, the communication time was too long and affects work/life, the communication content cannot solve the problem, the appointment time was forgotten/the appointment time was reached but the appointment time proportion were lower than those in the control group, the differences were statistically significant(P＜0.05); while the observation group′s poor response (not answering the phone/not sending a message/other)proportion was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Mobile Internet can improve the success rate of recruitment after blood donation loss.

Objective To explore the influence of risk assessment on the quality of infection control in operating room.Methods A total of 2668 patients who received surgeries in our hospital from January to December 2017 were assigned to the control group, and 2813 patients who received surgeries in our hospital from January to December 2018 were categorized into the intervention group. The patients in the control group were given routine nursing intervention, and high-risk links through risk assessment were selected and targeted intervention measures were adopted in the intervention group. The quality of infection prevention and control and the incidence of infection at the surgical site were compared between the two groups. Results The qualification rate of surface monitoring on the operation instruments, the standardization rate of aseptic operation, the qualification rate of surgical hand washing and preoperative skin preparation in the intervention group were all higher than those in the control group, the differences were statistically significant (P<0.05). The incidence of infection at the surgical site in the intervention group was 0.24%, which was lower than that in the control group accounting for 0.86%, and the difference was statistically significant (P<0.05). Conclusion The implementation of risk assessment and effective interventions on key links can significantly improve the quality of infection control in the operating room, which is worthy of clinical promotion and application.

Objective To investigate the effect of whole blood storage temperature and time on quality of cryoprecipitate coagulation factor. Methods A total of 120 bags (200 ml/bag) of whole blood collected in Central Blood Station of Foshan City from January to June in 2020 were selected as research objects and divided into room temperature group and low temperature group with 60 bags in each group. Each group was divided into three parts on average, 20 bags per part, and stored at room temperature (20-24℃) and low temperature (2-6℃) for 8, 12 and 24 h.Fresh frozen plasma was obtained by centrifugation, and cryoprecipitated coagulation factor was prepared within one week. The content of coagulation factor Ⅷ (FⅧ), the content of fibrinogen (FIB), the qualified rate of FⅧand the qualified rate of FIB in cryoprecipitated coagulation factor were determined. The content of FⅧ, the content of FIB, the qualified rate of FⅧand the qualified rate of FIB were compared between the two groups at different storage temperature and time. Results There were no statistically significant differences in the contents of FⅧand FIB stored for 8, 12, 24 h between the two groups (P>0.05). There were no statistically significant differences in the contents of FⅧand FIB stored for 8 h and 12 h (P>0.05). The contents of FⅧand FIB stored for 24 h in the two groups were higher than those stored for 8 h, and the differences were statistically significant (P<0.05). In the low temperature group stored for 8, 12, 24 h, the FⅧqualified rate was 100.00%, 95.00% and 90.00% respectively, compared with room temperature group of 100.00%, 95.00%, 85.00%, there were no statistically significant differences (P>0.05). In the low temperature group stored for 8, 12, 24 h, the qualified rates of FIB were 100.00%, 100.00%, and 95.00%, respectively, which showed no statistically significant differences compared with 100.00%, 100.00%, and 95.00% in the room temperature group (P>0.05). The FIB qualified rates of the two groups stored for 12, 24 h were compared with stored for 8 h, and the differences were not statistically significant (P>0.05). Conclusion There is no significant difference in the activity of cryoprecipitated coagulation factor between whole blood stored at room temperature and at low temperature within 24 h.

Objective To study and analyze the construction and application effect of the monitoring platform for pharmaceutical management in medical institutions. Methods A total of 150 cases of patients before the implementation of the drug management monitoring platform from April to October 2017 were taken as the control group, and 150 patients after the implementation of the drug management monitoring platform from September 2018 to March 2019 were taken as the observation group. The drug management, irrational drug use and patient satisfaction of the two groups were compared and analyzed. Results In the drug management of the two groups, the observation group was better than the control group, the difference was statistically significant (P＜0.05). The incidence of irrational drug used in the observation group (3.33%) was lower than that in the control group (11.33%), and the difference was statistically significant(P＜0.05). The satisfaction rate of the observation group (98.67%) was higher than that in the control group (92.67%),and the difference was statistically significant (P＜0.05). After the comprehensive implementation of the drug management monitoring platform, the average pneumonia of patients in hospital was significantly reduced, the use intensity of antibacterial drugs was reduced, and the monthly single dose dosage was significantly increased. Conclusion The construction and application of the drug management monitoring platform can improve the overall drug management level of the hospital, reduce the occurrence of unreasonable drug use, and increase the satisfaction of patients.

Since December 2019, Corona Virus Disease 2019 (COVID-19) emerged in Wuhan City and Hubei Province, and now has spread to the whole country. As a designated hospital of receiving and treating patients infected with COVID-19 in Shiyan City, Hubei Province, our hospital required all departments to take science-based and targeted measures, and make full efforts in prevention and control. According to the policies and regulations and the latest reports issued by the National Health Commission, the epidemiological and clinical characteristics of COVID-19 and the guidelines on COVID-19 prevention and control issued by the country and our hospital, department of orthopedics developed COVID-19 prevention and control measures in combination with our own experience in clinical prevention and control, which are suitable for outpatient and emergency department of orthopedics of tertiary general hospitals, so as to provide reference for the prevention and control of COVID-19 in various subspecialties of orthopedics and other surgical specialties.

Objective To explore the application effect of flipped classroom combined with teaching competition in the training of newly recruited nurses in operating room. Methods Fifteen newly recruited nurses who entered our hospital from June to August 2017 were selected as control group, and 15 newly recruited nurses who entered our hospital from June to August 2018 were selected as observation group.The control group adopted ″tutor mentoring and core competence training″ mode, and in the observation group″ flipped classroom and teaching competition″ was added on the basis of the control group. The time of training for both groups was one year. The assessment results (theory and operation), the satisfaction rate of the newly recruited nurses with the training, and the satisfaction rate of the doctors with the newly recruited nurses in the two groups were recorded. Results The theoretical and operational scores of the observation group were (91.89±2.80) points and (90.10±1.70) points, respectively. The theoretical and operational scores of the control group were (80.74±3.33) points and (83.38±3.09) points, respectively. The theoretical and operational scores of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.01）. The observation group′s satisfaction with training was higher than that of the control group, and the difference was statistically significant (P＜0.01）. The doctors′ satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.01）. Conclusion The tutor system has been a teaching mode in operating room for a long time, and the core competence training is a standardized training with comprehensive content and strong scientificity. Flipped classroom and teaching competition can greatly increase the enthusiasm of tutors and new nurses. It has the characteristics of inheritance，scientificity and innovation, which is worthy of promoting.

Objective To explore the application effect of scenario-simulated pre-service training in improving the blood-occupational exposure protection ability of interns. Methods A total of 168 undergraduate students who were internship in Jiangjin District Central Hospital majoring in clinical medicine at Chongqing Medical University were selected by convenient sampling method. The 83 interns from April 2016 to March 2017 were observation group. The 85 interns from April 2015 to March 2016 were the control group. The observation group used the scenario simulation teaching method for pre-job training, and the control group used the traditional teaching method. The theoretical knowledge and practical operation ability of blood-borne occupational exposure protection before and after the two groups of interns were compared, and the teaching evaluation of the two groups of interns on the pre-job training was compared. Results The theoretical assessment and skill assessment results of the observation group were higher than those of the control group, with statistical differences (P<0.05). The satisfaction degree of interns in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Through the scenario simulation pre-job training, the interns′ blood-borne occupational exposure protection ability has been greatly improved, which is worthy of promotion in clinical teaching.

Eosinophilic gastroenteritis is a rare disease. Due to the clinical manifestations of EGE are diverse and non-specificity, patients are often misdiagnosed and underdiagnosed. A case was admitted to Lanzhou University Second Hospital on April 6, 2020, manifested as "abdominal pain and gastrointestinal bleeding" and finally diagnosed as"eosinophilic gastroenteritis" by endoscopy combined with pathological examination. After diet management and taking the medicine of glucocorticoids and Montelukast, the child was cured without recurrence. To deepen clinicians′understanding of eosinophilic gastroenteritis, this article summarizes the process of clinical diagnosis and treatment, and reviews the latest literature, emphasizing that multi-site biopsy is of great use to diagnose eosinophilic gastroenteritis,and diet and hormones are the main therapies for eosinophilic gastroenteritis.

Objective To explore the application effect of self-management intervention in patients with permanent pacemaker implantation. Methods From July 2018 to June 2019, a total of 60 patients with permanent pacemaker implantation in our hospital were randomly assigned according to the sequence of admission time. The single number was defined as the experimental group(30 cases) and the double number as the control group (30 cases). Routine nursing and discharge guidance were carried out in the control group, and self-management intervention was added in the experimental group on the basis of the control group. The total satisfaction, the quality of life instrument for patients with pacemaker (QLIPPV1.0) score before and after the intervention, and the occurrence of adverse events of the patients in the two groups with the perioperative intervention mode were compared. Results The total satisfaction degree of patients in the experimental group was 96.7%, higher than 80.0% in the control group, the difference was statistically significant (P＜0.05); the score of QLIPPV1.0 in experimental group after the intervention was lower than that in the control group, the difference was statistically significant (P＜0.05); the incidence of adverse events was only lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Self-management intervention can help patients implanted with permanent artificial cardiac pacemakers improve their self-management ability, improve their life and quality of life after discharge, reduce the occurrence of adverse events related to pacemaker implantation,and make patients satisfied with the intervention model significantly improved.

Objective To explore the application effect of high quality nursing intervention in the elderly patients with lung cancer undergoing single hole thoracoscopy. Methods From May 2018 to May 2019, 100 elderly patients with lung cancer undergoing single hole thoracoscopic radical surgery in our hospital were selected as the study objects. They were divided into control group (n=50) and study group (n=50) by drawing lots at random. The patients in the control group were treated with routine nursing methods and the patients in the study group were treated with quality nursing intervention. Results The amount of intraoperative bleeding and postoperative drainage in the study group were less than those in the control group, with statistical differences (P<0.05). The retention time of drainage tube in the study group was shorter than that in the control group (P<0.05). The C-reactive protein (CRP) and scores of visual analogue scale (VAS) in the study group were lower than those in the control group, the differences were statistically significant(P<0.05). The total satisfaction of nursing in the study group was higher than that in the control group, the difference was statistically significant (P<0.05). Conclusion It is of great value to carry out high-quality nursing interventions in combination with the disease characteristics of elderly patients undergoing single hole thoracoscopic lung cancer radical operation.

Objective To explore the influence of meticulous nursing management on the psychological state, quality of life and prognosis of patients with endometrial polyp. Methods From October 2018 to October 2019, 90 patients with endometrial polyps treated in our hospital were selected and divided into two groups, 45 cases in each group. Routine nursing was used in the control group, and meticulous nursing management was used in the observation group on the basis of the control group. The mental state, quality of life and complications of the two groups before and after nursing were compared. Results The scores of HAMA was (8.06±3.12) points and HAMD was (8.42±2.70) points in the observation group, were lower than those in the control group of (10.36±3.02) and (9.65±2.65) points, the differences were statistically significant (P<0.05). The scores of social function was (91.25±3.68) points, physical life was (92.36±3.33)points, psychological function was (90.36±3.45) points and physical function was (93.45±2.24) points in the observation group, which were higher than those in the control group of (80.36±3.25), (81.36±3.25), (83.25±2.22) and (85.26±2.22)points, with statistical differences (P<0.05). The total incidence of postoperative complications in the observation group(6.66%) was lower than that in the control group (26.67%), with statistical difference (P<0.05). Conclusion The fine nursing management in patients with endometrial polyp can significantly improve the psychological status of patients,reduce the occurrence of complications, improve the quality of life, and is conducive to the prognosis.

Objective To explore and analyze the influencing factors and intervention strategies of central venous catheter (CVC) infection in hemodialysis (HD). Methods A total of 224 patients with HD admitted to our hospital from January 2018 to August 2019 were selected. The clinical diagnosis and treatment data of all patients were collected and retrospectively analyzed. The single factors and independent risk factors related to the occurrence of CVC infection in patients with HD were analyzed. Results Twelve of the 224 (5.4%) patients had CVC infection. The single factors related to the occurrence of CVC infection in patients with HD was age, combined with primary disease, indwelling time of CVC, the differences were statistically significant (P<0.05). The independent risk factors related to the occurrence of CVC infection in patients with HD were age≥60, combined with primary disease, indwelling time of CVC≥10 d (P<0.05). Conclusion The independent risk factors that related CVC infection in patients with HD are patients′age, primary disease, indwelling time of CVC. Targeted intervention on these risk factors is the key to reduce the incidence and ratio of CVC infection in patients with HD in clinic.

Objective To explore the effect of targeted nursing based on risk assessment on the rehabilitation process and nursing satisfaction of patients with acute upper gastrointestinal hemorrhage. Methods A total of 56 patients with acute upper gastrointestinal hemorrhage treated in our hospital from July 2017 to August 2019 were selected as the study objects. They were divided into two groups according to random number table method, 28 cases in each group.Routine nursing was used in the control group and targeted nursing based on risk assessment was used in the observation group. The hemostasis time, hospitalization time, hospitalization expenses, complications within 6 months and total nursing satisfaction were compared between the two groups. Results The hemostasis time was (2.36±0.60) d and hospitalization time was (6.91±3.78) d in the observation group, were shorter than those in the control group of (3.90±0.70)and (10.75±2.77) d, and the hospitalization cost was (3789.65±630.66) yuan in the obeservation group, which was lower than that in the control group of (4255.33±840.25) yuan, the differences were statistically significant (P<0.05). The total incidence of complications in the observation group was 7.14%, lower than that in the control group (32.14%), total nursing satisfaction was 92.86% in the obeservation group, higher than that in the control group (64.29%), the differences were statistically significant (P<0.05). Conclusion The targeted nursing based on risk assessment can significantly shorten the hemostasis time and hospitalization time of patients with acute upper gastrointestinal hemorrhage, reduce the hospitalization cost, reduce the incidence of complications, and improve the nursing satisfaction of patients, with high clinical application value.

Objective To explore the effects of health education, traditional Chinese medicine nursing and psychological intervention on patients with chronic hepatitis B. Methods From January to December 2018, 100 patients with chronic hepatitis B treated in our hospital were selected as subject and divided as subjects into control group (n=50)and study group (n=50) according to random number table method. Health education and psychological intervention were carried out in the control group, on the basis of control group, the study group was combined with traditional Chinese medicine nursing. The psychological state and nursing satisfaction of the two groups before and after nursing were compared. Results The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) before nursing in the study group were (61.75±2.60) and (61.85±2.85) points, respectively, and they were (61.80±2.55) and (61.90±2.80) points in the control group. There was no significant difference between the two groups (P＞0.05). After nursing,the SAS score and SDS score of the study group were (37.35±1.50) and (38.50±1.35) points, which were lower than those of the control group of (47.85±1.85) and (49.45±1.70) points, the differences were statistically significant (P<0.05). The total satisfaction rate of clinical nursing in the study group was 96.00%, which was higher than that in the control group (80.00%), the difference was statistically significant (P<0.05). Conclusion The effect of health education,traditional Chinese medicine nursing and psychological intervention on patients with chronic hepatitis B is accurate.

Objective To explore the effect of extended nursing based on WeChat platform on patients discharged from hospital after severe hand trauma. Methods A total of Fifty patients with hand trauma treated in our hospital from June 2017 to December 2018 were selected as subjects and divided into control group (n=25) and observation group (n=25)according to random number table method. The control group was treated with routine nursing. The observation group was treated with extended nursing based on WeChat platform. The Carroll upper limb function score, hand sensory function grade, incidence of complications and exercise compliance rate were compared between the two groups after 6 months of intotal tervention. Results The Carroll upper limb function score, hand sensory function grade and exercise compliance rate in the observation group were higher than those in the control group, with statistical differences (P<0.05), and the total incidence of complications in the observation group was lower than that in the control group, with statistical difference (P<0.05). Conclusion Extended nursing based on WeChat platform promotes the recovery of hand function of patients with hand trauma, reduces the incidence of complications, improves exercise compliance, and helps patients take office as soon as possible to realize their personal value.

Objective To explore the application of high quality nursing in the nursing of elderly cataract. Methods From February 2017 to February 2019, 255 patients with senile cataract were selected and divided into control group（n=127） and observation group （n=128） by touch the ball randomly. The control group was given routine nursing，and the observation group was given high quality nursing. The disease health knowledge，anxiety，vision，hospitalization time and total incidence of adverse events were compared between the two groups. Results The qualified rate of disease health knowledge in the observation group was 96.1%，which was higher than that in the control group （78.7%），the Zung self-rating anxiety scale （SAS） score in the observation group was lower than that in the control group，the postoperative visual acuity was higher than that in the control group，and the hospitalization time was shorter than that in the control group，the differences were statistically significant （P<0.05）. The total incidence of adverse events in the observation group was 3.1%, lower than that in the control group （16.5%），the difference was statistically significant（P<0.05）. Conclusion The application effect of high quality nursing in elderly cataract nursing is remarkable and can be popularized.

Objective To explore the application effect of early nutritional nursing intervention on patients with gastric and duodenal ulcer perforation repair. Methods A total of 94 patients with perforation of gastric and duodenal ulcers who underwent repair in our hospital from May 2018 to April 2019 were selected. They were divided control group and observation group according to the coin flip method, 47 cases in each group. The control group was given routine nursing, the observation group implemented early nutritional nursing intervention on the basis of routine nursing, the intervention effect of the two groups was compared. Results After the intervention, the nutritional status of both groups was improved, and the nutritional status indicators such as transferring, serum albumin, and hemoglobin in the observation group were higher than those in the control group, with statistical differences (P<0.05). The time of gastrointestinal function recovery in the observation group after first ventilation, diet recovery, and postoperative first defecation were shorter than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Early nutritional nursing intervention in patients with gastroduodenal ulcer perforation repair can improve the nutritional status of patients, promote gastrointestinal function recovery, and have good clinical application effect.

Objective To explore the clinical effect of humanistic care in the postoperative care of senile cataract patients. Methods A total of 85 cases of senile cataract patients in our hospital from February 2018 to July 2019 were selected and divided into group A (n=42) and group B (n=43) by single and double serial number method. Group A was given routine nursing care, and group B was given humanistic care. The total incidence of complications, self rating anxiety scale (SAS) and self rating depression scale (SDS) scores and total nursing satisfaction were compared between the two groups. Results The total incidence of infection, corneal edema and other complications in group B was lower than that in group A; the SAS and SDS scores of group B were lower than those of group A; the nursing total satisfaction of group B was higher than that of group A, and the differences were statistically significant (P<0.05).Conclusion It can reduce the incidence of complications, relieve the anxiety, depression and other negative emotions,and improve nursing satisfaction of elderly patients by integrating humanisic care in the postoperative care.

Objective To explore the clinical effect of nursing-patient communication in the nursing of hypertension patients. Methods A total of 120 hypertensive patients admitted to our hospital from April 2017 to October 2018 were selected as the study objects. According to the alternating grouping method, the patients were divided into the reference group (n=60) and the nursing group (n=60). Routine communication nursing was used in the reference group and good communication nursing was used in the nursing group. The compliance scores and the degree of anxiety and depression before and after nursing were compared between the two groups. Compliance scale (MMAS-8) was used to evaluate the compliance of the two groups, and Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used to evaluate the psychological state before and after nursing. Results There was no significant difference in MMAS-8 score between the two groups before nursing (P＞0.05). After nursing, the MMAS-8 score of nursing group was (6.05±0.39) points, which was higher than that of reference group of (5.12±0.65) points, the difference was statistically significant (P<0.05). Before nursing, there were no significant difference in HAMA and HAMD scores between the two groups (P＞0.05). After nursing, the HAMA and HAMD scores of the nursing group were lower than those of the reference group, the differences were statistically significant (P<0.05). Conclusion Compared with the routine communication nursing, the application of nurse patient communication in the nursing of hypertension patients has more obvious clinical advantages, which can effectively alleviate the bad mood, and improve the cooperation degree of patients′ treatment and nursing. It has a certain clinical value and is worthy of clinical promotion.

Objective To explore the application effect of cluster nursing intervention in the treatment of Ⅱ-Ⅳstage mixed hemorrhoids patients with internal hemorrhoids ligation. Methods A total of 82 patients with stage Ⅱ-Ⅳmixed hemorrhoids in our hospital were treated with internal hemorrhoids ligation. The patients were divided into two groups by red blue double color ball method, 41 cases in each group. The patients in the control group were given routine nursing. The observation group was given cluster nursing intervention on the basis of the control group. The postoperative pain of the patients in the two groups was compared, and the quality of life before and after nursing was evaluated.The complications were observed. Results There was no significant difference between the pain score postoperative 6 h was (3.54±0.52) points of the observation group and the control group of (3.61±0.55) points (P＞0.05); the pain score postoperative 12 h was (2.68±0.51) points, the pain score postoperative 24 h was (1.84±0.41) points and the pain score postoperative 48 h was (1.09±.27) points of the observation group were lower than those of the control group in the above period of (3.23±0.48), (2.38±0.49), (1.52±0.31) points, the differences were statistically significant (P<0.05).There was no significant difference in the quality of life score of the observation group before nursing of (62.31±7.92)points compared with that of the control group of (62.58±7.16) points (P＞0.05); the quality of life score of the observation group after nursing was (76.53±8.39) points, was higher than that of the control group of (69.62±7.47) points, and the difference was statistically significant (P<0.05). The total incidence of complications in the observation group(7.32%) was lower than that of the control group (24.39%), the difference was statistically significant (P<0.05). Conclusion The effect of cluster nursing intervention in the treatment of Ⅱ-Ⅳstage mixed hemorrhoids patients with internal hemorrhoids ligation is definite.

Objective To explore the application effect of integrated nursing in elderly patients with coronary heart disease (CHD) and heart failure (HF). Methods A total of 80 elderly patients with CHD and HF admitted to our hospital from August 2018 to August 2019 were selected as the study objects. According to the odd even grouping mode, they were divided into control group and study group, 40 cases in each group. The control group was given routine nursing,and the study group was given integrated nursing. The compliance, quality of life and satisfaction of nursing of the two groups were compared. Results The compliance of exercise, reasonable diet, medication and reexamination in the study group were higher than those in the control group, with statistical differences (P<0.05). There was no significant difference in the quality of life score between the two groups before nursing (P＞0.05). The quality of life score of the two groups after nursing were higher than those before nursing, the quality of life score of the study group after nursing was higher than that of the control group, and the differences were statistically significant (P<0.05). The nursing total satisfaction of the study group was higher than that of the control group, with statistical difference (P<0.05). Conclusion The application of integrated nursing in elderly patients with CHD and HF has a reliable effect, which can improve the compliance of patients, improve the relationship between nurses and patients, and improve the quality of life of patients, so it has a positive significance in clinical promotion.

Objective To observe the application effect of targeted nursing on the elderly patients with chronic obstructive pulmonary disease (COPD) in ICU. Methods From October 2017 to October 2019, 144 elderly patients with Ⅱ, Ⅲgrade COPD and infection in ICU were selected as the research objects. They were divided into control group (n=72)and experimental group (n=72) according to random number table method. The patients in the control group received routine nursing intervention, while the patients in the experimental group received targeted nursing intervention. Before and after the intervention, the blood gas indexes, respiratory rate, ICU treatment time, treatment weaning rate and ICU transfer rate were compared between the two groups. Results There was no significant difference of blood gas indexes between the two groups (P＞0.05). After intervention, the partial pressure of carbon dioxide (PaCO2) in the experimental group was lower than that in the control group, and PaO2, hydrogen carbonate (HCO3-) and oxygen saturation of blood(SaO2) in the experimental group were higher than those in the control group, the differences were statistically significant (P<0.05). There was no significant difference in respiratory rate between the two groups before intervention (P＞0.05). After intervention, the respiratory rate of patients in the experimental group was lower than that in the control group, and the duration of ICU treatment in the experimental group was shorter than that in the control group, the differences were statistically significant (P<0.05). The weaning rate in the experimental group was 88.89%, which was higher than 65.28% in the control group, while the ICU transfer rate in the experimental group was 94.44%, which was higher than 77.78% in the control group, the differences were statistically significant (P<0.05). Conclusion Targeted nursing intervention can significantly improve the levels of blood gas indexes, reduce the respiratory rate, shorten the time for ICU patients to receive treatment, increase the off-line rate of treatment, and improve the ICU transfer out rate after the improvement.

Objective To explore the application effect of high quality nursing in postpartum hemorrhage patients with pregnancy hypertension syndrome. Methods A total of 110 cases of postpartum hemorrhage with gestational hypertension syndrome diagnosed and treated in our hospital from March to December 2019 were selected as the research objects. According to the random number table method, they were divided into the control group and the quality group,with 55 cases in each group. The control group was given routine nursing intervention, and the quality group was given quality nursing services on the basis of the control group. The blood pressure, blood loss and quality of life of patients were compared between the two groups. Results After the intervention, the blood pressure level of patients in the high quality group was lower than that of the control group, the amount of postpartum blood loss at 2 and 24 h were less than those of the control group, and the scores of each quality of life index were higher than those of the control group,with statistically significant differences (P＜0.05). Conclusion Quality nursing intervention can effectively improve the quality of life and blood pressure level of postpartum hemorrhage patients with gestational hypertension syndrome.

Objective To explore the effect of targeted nursing on psychological status and living standards of patients with gallstone surgery. Methods A total of 68 patients with gallstones treated in our hospital from June 2018 to August 2019 were selected as the research subjects, and they were divided into reference group (n=34) and research group (n=34) according to the random throw method. The reference group carried out routine nursing, the research group implemented targeted nursing interventions, the self-rating anxiety scale (SAS), self-rating depression scale (SDS) scores,postoperative pain tolerance rate and quality of life scores between the two groups were compared. Results There were no significant differences in SAS and SDS scores of patients between the two groups before intervention (P＞0.05). The SAS and SDS scores of the research group after the nursing intervention were lower than those of the reference group,and the differences were statistically significant (P<0.05). The pain tolerance rate in the research group was 91.18%,which was higher than 70.59% in the reference group, and the difference was statistically significant (P<0.05). The postoperative quality of life scores and each score in the research group were higher than thoset of the reference group,and the differences were statistically significant (P<0.05). Conclusion The effect of targeted nursing intervention on patients with gallstone surgery is significant.

Objective To explore the application effect of "Internet + health management" model in young and middleaged obese people. Methods The clinical data of 118 young and middle-aged obese patients who had physical examination in our hospital from January 2015 to December 2016 were retrospectively selected, with body mass index (BMI)≥28 kg/m2, aged 18 to 59 years old, and a self-controlled cohort was used, intervened with the "Internet + health management" model to observe the weight management effect of obese people before and after intervention. Results The health management model was used to manage weight for 118 young and middle-aged obese persons for 12 months. The body weight, hip circumference, waist circumference, BMI at 6 months and 12 months and triglycerides at 12 months after intervention were lower than those before intervention, and the differences were statistically significant(P<0.05). The triglycerides, cholesterol, fasting blood glucose, systolic blood pressure, and diastolic blood pressure at 6 months after intervention were lower than those before intervention, but the differences were not statistically significant(P>0.05). The cholesterol, systolic blood pressure and diastolic blood pressure at 12 months after intervention were lower than those before intervention, the differencea were statistically significant (P<0.05). The body weight, hip circumference, waist circumference, BMI, triglyceride, cholesterol and diastolic blood pressure values at 12 months after intervention were lower than those at 6 months after intervention, the differences were statistically significant (P<0.05).Conclusion The "Internet + health management" model has a good effect on the weight management of young and middle-aged obese people and is worthy of clinical application.

Objective To understand the health status of community residents in Baise City, and to explore the application effect of medical micro-class in order to provide a reference for clinical intervention.Methods A total of 372 residents who lived in the community in Baise City from June 2018 to June 2019 were selected as the research subjects.From June to December 2018,routine health education in the community were conducted,and from January to June 2019,the medical micro-class intervention with the help of the community were implemented.The first questionnaire survey in December 2018 were conducted,and after half-year medical micro-class intervention,the second questionnaire survey in June 2019 were conducted. The awareness rates of resident health standard, health knowledge, targeted poverty alleviation policy and medical insurance policy before and after intervention were compared. Results According to the investigation, the overall health status of 372 residents in Baise City was good,of which 102 residents had chronic diseases,accounting for 27.42%. The chronic diseases were mainly hypertension and diabetes mellitus, respectively accounting for 44.12% and 32.35%. After intervention, the awareness rates of community health standards, health knowledge, targeted poverty alleviation policy and medical insurance policy in Baise City were higher than before with statistical significance (P<0.05).Conclusion The overall health status of residents in Baise City is good. The implementation of medical micro-class intervention can improve the awareness rates of residents′ health standards, health knowledge, targeted poverty alleviation policy, and medical insurance policy. It obtains a satisfactory application effect and deserves further promotion.

Objective To analyze the test results of avian influenza specimens in external environment of Meizhou′s poultry market during the period from 2017 to 2019, provide reasonable basis on the disease prevention and control.Methods From January 2017 to December 2019, 4176 specimens from external environment of Meizhou′s poultry market were obtained. Fluorescent quantitative PCR was applied to detect nuclein acid, H5, H7 and H9 subtypes of avian influenza A virus. Environmental pollution conditions were examined. Results Test results indicated that the detection rate of avian influenza A virus in 2018 was higher than that in 2017 and 2019. H5 and H9 infection rate was increased while H7 rate was decreased. The cases with virus subtypes from chopping board countertops, knife sticky boards,poultry manure, weighing pans were substantially increased. Conclusion Many virus subtypes are generated in the external environment of Meizhou poultry market, especially for those of animal slaughter and selling booths. Therefore, the disinfection system of poultry market environment shall be implemented for protection of focus groups.

The department of emergency is an important department of the hospital, which is responsible for the treatment of various critically ill patients. Emergency and first aid is a rescue measure implemented by the hospital′s emergency department for critically ill patients. It belongs to an emerging comprehensive discipline and involves multiple medical fields. With the change of the clinical medical model from the previous biomedical model to the bio-physiological-social medical model, the original emergency management of the emergency department of the hospital can not adapt to the current emergency service of emergency department, and can not meet the needs of patients during emergency department. In order to improve the quality of emergency and emergency management in our hospital, due attention should be paid to emergency and emergency management in our hospital, focusing on the current state of emergency and emergency management in our hospital, and improving emergency and emergency management. This article first describes the current situation of emergency management in our hospital, and then analyzes how to improve the emergency management in our hospital.