细胞焦亡的分子机制及研究进展

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Abstract

Pyroptosis is a pattern of atypical cell death driven by inflammasome, mediated by Caspase-1/-11/-4/5.Gasdermin family proteins are identified as pore-forming proteins acting as the "executor" of pyroptosis, which usually remain in self-suppressed state. Gasdermin D and Gasdermin E are the most key palyers in pyroptosis. In the pathway of pyroptosis, GSDMD/GSDME is cleaved into N-terminal pore-forming fragments and C-terminal inhibitory fragments by activated Caspases, membrane perforation is initiated in turn, and cell contents such as inflammatory factors are released to trigger pyroptosis. Emerging evidences support that pyroptosis plays an important role in the development of various diseases, especially in tumors. This article summarizes the underlying molecular mechanism of pyroptosis and reviews the research progress in cancer.

Key words： Pyroptosis Programmed cell death Inflammasome Tumor GSDMD

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