Objective To explore the clinical effect of nursing-patient communication in the nursing of hypertension patients. Methods A total of 120 hypertensive patients admitted to our hospital from April 2017 to October 2018 were selected as the study objects. According to the alternating grouping method, the patients were divided into the reference group (n=60) and the nursing group (n=60). Routine communication nursing was used in the reference group and good communication nursing was used in the nursing group. The compliance scores and the degree of anxiety and depression before and after nursing were compared between the two groups. Compliance scale (MMAS-8) was used to evaluate the compliance of the two groups, and Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used to evaluate the psychological state before and after nursing. Results There was no significant difference in MMAS-8 score between the two groups before nursing (P＞0.05). After nursing, the MMAS-8 score of nursing group was (6.05±0.39) points, which was higher than that of reference group of (5.12±0.65) points, the difference was statistically significant (P<0.05). Before nursing, there were no significant difference in HAMA and HAMD scores between the two groups (P＞0.05). After nursing, the HAMA and HAMD scores of the nursing group were lower than those of the reference group, the differences were statistically significant (P<0.05). Conclusion Compared with the routine communication nursing, the application of nurse patient communication in the nursing of hypertension patients has more obvious clinical advantages, which can effectively alleviate the bad mood, and improve the cooperation degree of patients′ treatment and nursing. It has a certain clinical value and is worthy of clinical promotion.