Objective To explore the influence of meticulous nursing management on the psychological state, quality of life and prognosis of patients with endometrial polyp. Methods From October 2018 to October 2019, 90 patients with endometrial polyps treated in our hospital were selected and divided into two groups, 45 cases in each group. Routine nursing was used in the control group, and meticulous nursing management was used in the observation group on the basis of the control group. The mental state, quality of life and complications of the two groups before and after nursing were compared. Results The scores of HAMA was (8.06±3.12) points and HAMD was (8.42±2.70) points in the observation group, were lower than those in the control group of (10.36±3.02) and (9.65±2.65) points, the differences were statistically significant (P<0.05). The scores of social function was (91.25±3.68) points, physical life was (92.36±3.33)points, psychological function was (90.36±3.45) points and physical function was (93.45±2.24) points in the observation group, which were higher than those in the control group of (80.36±3.25), (81.36±3.25), (83.25±2.22) and (85.26±2.22)points, with statistical differences (P<0.05). The total incidence of postoperative complications in the observation group(6.66%) was lower than that in the control group (26.67%), with statistical difference (P<0.05). Conclusion The fine nursing management in patients with endometrial polyp can significantly improve the psychological status of patients,reduce the occurrence of complications, improve the quality of life, and is conducive to the prognosis.