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2021 Vol. 28, No. 9 Published: 2021-03-28

	4	Study on the action mechanism of Gleditsiae Spina in the treatment of breast cancer based on network pharmacology
		QUAN Qi ;CHEN Ping ;HUANG Yuan-yuan; ZHANG Bei▲
		Objective To explore the key targets and signal pathways of Gleditsiae Spina in the treatment of breast cancer and provide a basis and some evidence for further research.Methods Chemical components and targets of Gleditsiae Spina and the targets related to breast cancer were collected by searching databases.Common targets were mapped out by using R language.A protein interaction network (PPI) was constructed to extract key targets.GO and KEGG enrichment analysis were performed by using R language."Component-target" and "target-pathway" network was built to extract key targets and pathways.Results Eleven active ingredients and 174 targets of Gleditsiae Spina,1132 targets related to breast cancer and 88 common targets were obtained after screening.Total 104 GO entries and 144 KEGG signal paths were yielded by enrichment analysis.Three key targets in the PPI network were enriched in key pathways.The targets were MAPK1,AKT1,RELA and the pathways involved were cancer,cell apoptosis,TNF signaling pathway,infection,IL-17 signaling pathway and endocrine resistance.Conclusion Gleditsiae Spina may play an anti-breast cancer effect by targeting MAPK1,AKT1 and RELA in related pathways.
		2021 Vol. 28 (9): 4-8转13 [Abstract] ( 49 ) HTML (35 KB) PDF (0 KB) ( 7 )

	9	Analysis of clinical characteristics and prognostic factors of gastric cancer in young patients
		FENG Shi ;ZHOU Bo; CAO Xian-dong▲
		]Objective To explore the clinical characteristics and prognostic factors of gastric cancer in young patients.Methods Clinical data of patients with gastric cancer admitted to the First Affiliated Hospital of Anhui Medical University from January 2013 to December 2017 were collected.A total of 94 patients with stage Ⅰ-Ⅲgastric cancer (age≤40) were selected as the study group,and according to propensity score matching (PSM) method,94 middle-aged and elderly patients (age＞40) were selected as the control group.The clinical data of the two groups were compared to explore the clinical characteristics of young gastric cancer and to analyze and evaluate the prognostic factors of young gastric cancer.Results The proportion of female patients in the study group was higher than that in the control group,the basic disease was less than that in the control group,the differentiation degree of histological type was lower than that in the control group,and the incidence of gastric proximal tumor was lower than that in the control group,and the differences were statistically significant (P＜0.05).Univariate analysis showed that tumor location,tumor size,lymph node metastasis,TNM stage,gross classification,carcinoembryonic antigen (CEA),alphafetoprotein (AFP),carbohydrate antigen 125 (CA125) and carbohydrate antigen 19-9 (CA19-9) were related to the prognosis of young gastric cancer(P＜0.05).CA125 positive and advanced gastric cancer were independent risk factors for prognosis based on the multivariate analysis (P＜0.05).Conclusion In the case of matching baseline characteristics,the proportion of young patients with gastric cancer is relatively higher and the degree of tumor differentiation is lower,and CA125 positive and advanced gastric cancer are the poor prognostic factors of young gastric cancer.
		2021 Vol. 28 (9): 9-13 [Abstract] ( 49 ) HTML (39 KB) PDF (0 KB) ( 7 )

	14	Analysis of the influence of reinforced anastomosis on anastomotic fistula after laparoscopic anus-preserving operation for middle and low rectal cancer and its factors
		LI Zhen-sheng; WANG Chun-peng;CHEN Ruo-bing
		Objective To investigate the influence of laparoscopic anastomotic reinforcement on the occurrence of anastomotic fistula in patients with middle and low rectal cancer and the related factors of anastomotic fistula.Methods A total of 201 patients with middle and low rectal cancer undergoing anus preserving surgery in Liaoyang Central Hospital from June 2017 to December 2019 were selected as the research subjects.According to random number table method,they were divided into routine anastomosis group (100 cases) and reinforced anastomosis group (101 cases).The incidence and occurrence time of postoperative anastomotic fistula,operative time,intraoperative blood loss,time of postoperative exhaust and time of postoperative feeding were compared between the two groups,and the related factors of anastomotic fistula were analyzed.Results The incidence of anastomotic fistula in the reinforced anastomotic group was lower than that in the conventional anastomotic group,and the operation time was longer than that in the conventional anastomotic group,the differences were statistically significant (P＜0.05).There were no statistical significances in the occurrence time of anastomotic fistula,intraoperative blood loss,postoperative exhaust time and feeding time between the two groups (P＞0.05).Univariate analysis indicated that the anastomotic fistula group and the group without anastomotic fistula showed statistically significant differences in the anastomotic method,age,history of diabetes,history of hypertension and history of chemotherapy (P＜0.05).Multivariate analysis indicated that the history of chemotherapy (β=1.358,OR=3.889,95%CI 1.160-13.040),age≥50 years old (β=0.100,OR=1.105,95%CI 1.005-1.214) and routine anastomotic operation (β=1.948,OR=7.017,95%CI 2.220-22.183) were risk factors for postoperative anastomotic fistula in patients with moderate and low rectal cancer (P＜0.05).Conclusion Reinforcement anastomosis after laparoscopic anastomosis can reduce the occurrence of anastomotic fistula.Age≥50 years old and the history of chemotherapy and conventional anastomosis are the main risk factors for anastomotic fistula.
		2021 Vol. 28 (9): 14-17 [Abstract] ( 46 ) HTML (36 KB) PDF (0 KB) ( 7 )

	18	Study on the mechanism of Yiqi Qingdu Xiaoliu Recipe inducing intestinal cancer cell apoptosis
		TANG Xiao-ling; GUO Jian;XIONG Lin-kai;WANG Li-qin;XIONG Mo-nian▲
		Objective To analyze the mechanism of Professor XIONG Mo-nian′s Yiqi Qingdu Xiaoliu Recipe in inducing apoptosis mechanism of intestinal cancer cells.Methods A total of 40 clean-grade male Kunming mice were used.They were divided into high-dose,medium-dose,and low-dose groups and the control group according to the random number table method,with 10 rats in each group.The control group was given 0.2 mL of normal saline by gavage,and the other three groups were given different concentrations of Yiqi Qingdu Xiaoliu decoction.Each group was intragastric administration twice every day for 3 days.One hour after the last administration,blood was collected from the inferior vena cava to prepare drug-containing serum.Using equal volumes of different concentrations of mouse drug-containing serum to treat human colorectal cancer Wide cell line,each group has 4 multiple wells.After culturing for 12,24,and 48 hours,the OD value of each group of cells was measured,and the inhibition rate was calculated;the morphology and apoptosis of each group were observed,and the protein expression of Bcl-2,Bax,and Fas of each group was detected.Results The cell inhibition rate of each group was presented as a time-and dose-dependent relationship after 12,24,and 48 hours of cell culture.The proportion of necrotic cells in the high-dose group was higher than those in the control group,the low-dose group and the middle-dose group,the differences were statistically significant (P＜0.05).After 24 hours,the apoptosis rate showed a significant dose-dependent relationship (P＜0.05).The expression of apoptosis regulating genes Bax and Fas in the drug serum intervention group was higher than that of the control group,and the expression of Bcl-2 was lower than that of the control group,the differences were statistically significant (P＜0.05);and with the increase of the dose,the expression of Bax and Fas increased,and the expression of Bcl-2 decreased significantly,the differences were statistically significant (P＜0.05).Conclusion Yiqi Qingdu Xiaoliu Recipe can increase the expression of Bax and Fas,inhibit the expression of Bcl-2,inhibit the growth and proliferation of intestinal cancer cells,and effectively promote cell apoptosis
		2021 Vol. 28 (9): 18-21 [Abstract] ( 47 ) HTML (41 KB) PDF (0 KB) ( 8 )

	22	Expression of BuB3 and BUBR1 in villus and decidual tissues of patients with recurrent miscarriage
		ZHAO Juan; LI Hui;CHEN Guang-xin; DU Li-jun;ZHANG Xiao-li;CAO Tian-sheng▲
		Objective To investigate the expression of BUB3 and Bub1 related proteins(BubR1)in the villus and decidual tissues of patients with recurrent miscarriage (RM)and their relationship with RM.Methods From March 2016 to March 2018,50 cases of missed abortion pregnant women in Huadu District People′s Hospital of Guangzhou were selected as the case group,and 50 cases of normal induced abortion women in the same period were selected as the control group.The age,body mass index(BMI),parity,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol (HDL-C) were collected.The mRNA and protein levels of BUB3 and BuBR1 in embryonic villus tissue(VT)and decidual tissue(DT)were determined by real-time quantitative fluorescence PCR(qRTPCR) and Western blot (WB) Logistic regression was used to analyze the influencing factors of RM.Results There were no significant differences in age,BMI,parity,TC,TG,LDL-C and HDL-C levels between the two groups(P＞0.05).The mRNA and protein expression levels of BUB3 and BubR1 in VT and DT in case group were lower than those in control group,and parity was more than that in control group,and the differences were statistically significant (P＜0.05).Logistic regression showed that the parity (β=0.461,OR=1.586,95%CI=1.253-2.007),BUB3 mRNA (β=0.710,OR=2.035,95%CI=1.602-2.585) and BubR1 mRNA (β=1.304,OR=3.685,95%CI=2.884-4.708) were independent risk factors for RM (P＜0.05).Conclusion The mRNA and protein levels of BUB3 and BubR1 are reduced in VT and DT of patients with RM.BUB3 and BubR1 mRNA are independent risk factors for the occurrence of RM and may be potential diagnostic indicators for RM.
		2021 Vol. 28 (9): 22-25 [Abstract] ( 58 ) HTML (35 KB) PDF (0 KB) ( 7 )

	26	Concentration determination of Voriconazole in patients plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in monitoring the plasma concentration of Voriconazole in patients with deep fungal infection
		GE Xin;LIU Yan-yan;LIU Ping
		Objective To develop an ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)method for determination of Voriconazole in patients plasma and apply it to drug monitoring.Methods UPLC-MS/MS method was adopted.Using fluconazole as internal standard,the plasma samples were alkalized with sodium hydroxide and extracted with ethyl acetate and analyzed.The separation was achieved on an Acquity UPLCR BEH-C18 column(2.1 mm×50 mm,1.7 μm) and eluted with linear gradient using water (containing 0.1% formic acid and 2 mmol/L ammonium formate)-acetonitrile at flow rate of 0.10 mL/min.The injection volume was 1 μL and the column temperature was 40℃.The total time of the analysis was 5.0 min.Detection of the analytes was achieved using positive ion electrospray ionization (ESI+) in the multiple reaction monitoring (MRM) mode.Results The linear range of voriconazole was 10-10 000 ng/mL (Y=1.303 93×10-3X+1.002 17,r=0.9992),with the lower limit of quantitation of 10 ng/mL.The accuracy of quality control sample was 95.2%-104.8%.Intra-day and inter-day relative standard deviations were both ＜7%.Method recovery was ＞95% (RSD＜7%) and extraction recovery was ＞75% (RSD＜5%).The plasma concentrations of Voriconazole in 12 patients with invasive fungal infection determined by this method were 817.29-9054.24 ng/mL,and of those 4 patients′ plasma concentrations were outside the recommended treatment concentration range.Conclusion The established method is rapid,sensitive,accurate,specific and repeatable,and can be applied for the therapeutic drug monitoring of Voriconazole.
		2021 Vol. 28 (9): 26-30转42 [Abstract] ( 44 ) HTML (39 KB) PDF (0 KB) ( 8 )

	31	Renal protection of vitamin D in diabetic nephropathy
		LI Ge-fei;MAO Yu-yi ;HAN Rui▲
		The classic role of vitamin D is to regulate the metabolism of calcium and phosphorus.In the past,it was mainly used to prevent or alleviate bone disease.However,more and more evidences show that vitamin D has more new applications.Among them,the protective effect of vitamin D in diabetic nephropathy has attracted much attention.Related animal studies have confirmed that vitamin D can reduce oxidative stress and accumulation of glycation products caused by hyperglycemia,inhibit the overactivation of renin-angiotensin system and reduce the production of inflammatory factors through multiple pathway,thus delaying the progression of diabetic nephropathy.Meanwhile,related clinical trials have documented that low vitamin D level is positively correlated with decreased proteinuria and renal function in diabetic patients.This review summarized the pathogenesis of diabetic nephropathy,and explored the multiple roles of vitamin D in reducing inflammation and delaying pathological changes,in order to explore more effective treatments for diabetic nephropathy.
		2021 Vol. 28 (9): 31-34转61 [Abstract] ( 55 ) HTML (45 KB) PDF (0 KB) ( 6 )

	35	Research progress of diabetic nephropathy
		DONG Yu-xin;NA Ren-gao-wa▲;LIU Yuan-fan;QI Xiao-xuan;HOU Yuan;WANG Tian-ci;GAO Rui-rong;WANG Yan-shu
		Diabetic nephropathy is a chronic kidney disease caused by diabetes.At present,the incidence of the disease is increasing rapidly.However,its pathogenesis is complex and the mechanism of the renal injury has not been completely discovered,so there is a lack of effective therapeutic drugs and means in clinical practice.Current studies suggest that it is closely related to heredity,abnormal glucose metabolism,abnormal lipid metabolism,microcirculation disorder,cytokine action,oxidative stress and other aspects.In this paper,the researches on the pathogenesis and the treatment of the diabetic nephropathy at home and abroad were reviewed,and various potential therapeutic targets of the diabetic nephropathy and the possible mechanisms of treatment were summarized,and more instructional clues can be provided for further exploration of the pathogenesis and the treatment of the diabetic nephropathy.
		2021 Vol. 28 (9): 35-38 [Abstract] ( 45 ) HTML (1 KB) PDF (0 KB) ( 7 )

	39	Research progress of intrapartum fever caused by epidural labor analgesia
		WANG Yu;YAN Yu-rong▲
		With the popularization of epidural analgesia technology and the increasing demand for parturients for reducing labor pain,more and more medical institutions have carried out labor analgesia.However,the adverse outcomes of maternal and infant caused by epidural related maternal fever (ERMF) have perplexed countless medical workers.The underlying pathophysiological processes of intrapartum fever remain elusive.It may be related to aseptic inflammatory reaction mediated by proinflammatory cytokines,the imbalance of maternal thermoregulation,the effect of local anesthetics,epidural puncture trauma and so on.Intrapartum fever may increase obstetric interventions,increase the rate of cesarean section,assist vaginal deliveries,and the use of antibiotics.It may affect the neonatal nervous system and increase neonatal antibiotic exposure.Therefore,a more comprehensive understanding of the etiology and harm of ERMF is conducive to taking effective measures to reduce its incidence and allow a better outcome of both mothers and infants.
		2021 Vol. 28 (9): 39-42 [Abstract] ( 61 ) HTML (1 KB) PDF (0 KB) ( 8 )

	43	Research progress on the prevention and control of digestive endoscopy infection under the normal control of COVID-19
		LIU Jun-ling
		The COVID-19 epidemic prevention and control in China has entered a phase of normalization.Digestive endoscopy diagnosis and treatment requires close contact among digestive endoscopist,nurses and patients in a closed space,which is a high-risk nosocomial infection route.The guidelines and clinical research conclusions in the field of digestive endoscopy infection prevention and control in the early stage of the epidemic are scattered,while there is a lack of a summary of the prevention and control of digestive endoscopy infection under the normal epidemic prevention and control.This review summarizes the research on the prevention and control of infection by digestive endoscopy under the normal control of COVID-19,in order to provide reference for the emergency management in diagnosis and treatment of digestive endoscopy of infectious diseases under the normal control of COVID-19.
		2021 Vol. 28 (9): 43-46 [Abstract] ( 54 ) HTML (38 KB) PDF (0 KB) ( 6 )

	47	Mechanism and related prevention and treatment of recurrence of thrombus after coronary intervention
		WANG Hong-ye; LEI Chao-hai▲
		The development of percutaneous coronary intervention (PCI) has brought unprecedented wish to patients with acute coronary syndrome (ACS),but the stent thrombosis is still a difficult problem to be overcome in the development of medical technology.Stent thrombosis is a rare complication of coronary intervention and is related to subsequent adverse events.From the early simple balloon expansion to the continuous improvement of drug-coated stent technology,the incidence of stent thrombosis has been markedly reduced.Meanwhile,assessment on patient′s past medical history and individualized risk,the application of anticoagulant and antiplatelet drugs,the development of early coronary thrombus recognition technology,the selection of coronary stents,and the application of thrombus aspiration serve as important parts for stent thrombosis reduction.This article summarized the causes,mechanisms and related prevention and treatment of stent thrombosis after coronary intervention.
		2021 Vol. 28 (9): 47-50 [Abstract] ( 44 ) HTML (39 KB) PDF (0 KB) ( 9 )

	51	Effect of Biatain Silicone Foam Dressing combined with Debridement Glue in the treatment of stage 3 and 4 stress injury
		HE Hong-mei; GUO Xin-ling; WEN Yue-xiu; LAI Fu-ying ;WU Yuan-yuan; LIU Juan ;LIU Li
		Objective To investigate the clinical effect of Biatain Silicone Foam Dressing combined with Debridement Glue in the treatment of stage 3 and 4 stress injury.Methods A total of 80 patients with stage 3 and 4 stress injury admitted to Ganzhou People′s Hospital from January 2019 to January 2020 were selected as the research subjects.According to random number table method,they were divided into experimental group and control group,with 40 cases in each group.The experimental group was treated with Biltan Silicone Foam Dressing combined with Debridement Glue,and the control group with Silver Ion Dressing combined with foam dressing,both groups were treated with continuous intervention for 30 d.Clinical treatment effect,granulation tissue covering time of wound,diameter reduction time,wound healing time,dressing change pain score,dressing change frequency and inpatient satisfaction were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant (P＜0.05),the granulation tissue covering time,diameter reduction time and wound healing time in the experimental group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The pain score and frequency of dressing change in the experimental group were lower than those in the control group,the differences were statistically significant (P＜0.05).The satisfaction of the experimental group was higher than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion The clinical effect of Biatain Silicone Foam Dressing combined with Debridement Glue in the treatment of patients with stage 3 and 4 pressure injury is remarkable,which is beneficial to shorten the time of granulation tissue covering wound,diameter reduction time,wound healing time,promote wound healing quickly,relieve patient pain and improve patient satisfaction.
		2021 Vol. 28 (9): 51-54 [Abstract] ( 59 ) HTML (37 KB) PDF (0 KB) ( 7 )

	55	Clinical effect and quality of life of patients with pelvic floor flaccid constipation treated with biofeedback
		YANG Xue-chun; SUN Bing; ZHANG Li
		Objective To investigate the clinical effect of biofeedback on pelvic floor flaccid constipation and its effect on patients′ quality of life.Methods A total of 80 patients with pelvic floor flaccid constipation admitted to Beijing Anorectal Hospital from December 2018 to December 2019 were selected as the research subjects.The patients were divided into the control group (40 cases) and the experimental group (40 cases) by random number table method.The control group was treated with surgery and the experimental group was treated with biofeedback therapy.Clinical constipation symptom scores,self-rating quality of life scale scores and clinical efficacy were compared between the two groups.Results After treatment,clinical constipation symptom scores in the experimental group were lower than those in the control group,the differences were statistically significant (P＜0.05).The score of quality of life in experimental group was lower than that in control group,and the difference was statistically significant (P＜0.05).The total effective rate of experimental group was higher than that of control group,the difference was statistically significant (P＜0.05).Conclusion Biofeedback therapy in the treatment of pelvic floor flaccid constipation can effectively improve the clinical symptoms of patients,improve their quality of life and treatment efficiency,which is worthy of promotion and application.
		2021 Vol. 28 (9): 55-57 [Abstract] ( 60 ) HTML (32 KB) PDF (0 KB) ( 7 )

	58	Effect of Chuankezhi Injection on acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure
		QIAN Xu-sheng; LIAN Le-shen ;LI Bi-fang; ZHU Bi-yuan; ZHU Xiao-jue; TAO Hai-lan ;XIE Xiao-jun
		Objective To investigate the effect of Chuankezhi Injection on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure.Methods A total of 122 patients with AECOPD complicated with respiratory failure (kidney-yang deficiency type) admitted to the Respiratory and Critical Care Medicine Department of Dongguan Hospital of Traditional Chinese Medicine from September 2019 to November 2020 were selected as the research subjects.According to the random number table method,they were divided into the treatment group and the control group,with 61 cases in each group.There was 1 case of shedding in each group and 60 cases of completion.The control group was treated with high flow respiratory humidification apparatus (AIRVO2),routine anti-infection,phlegm-reducing and anti-asthmatic treatment,the treatment group was given intramuscular Chuankezhi Injection on the basis of the control group,and both groups were treated for 14 days.The total effective rate,blood oxygen saturation (SpO2),peripheral white blood cell count (WBC),procalcitonin (PCT),malondialdehyde(MDA),superoxide dismutase (SOD),interleuk-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were compared between the two groups before and after treatment.Results The total effective rate of the treatment group was higher than that of the control group,the difference was statistically significant (P＜0.05).After treatment,the levels of WBC,PCT,MDA,IL-6 and TNF-α in both groups were lower than before treatment,and the levels of WBC,PCT,MDA,IL-6 and TNF-α in the treatment group were lower than those in the control group,the differences were statistically significant (P＜0.05).After treatment,the levels of SpO2 and SOD in both groups were higher than before treatment,and the levels of SpO2 and SOD in the treatment group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Chuankezhi Injection combined with AIRVO2 treatment can improve the clinical efficacy of AECOPD combined with respiratory failure,improve oxidative stress and inflammatory response,which is worthy of clinical application.
		2021 Vol. 28 (9): 58-61 [Abstract] ( 53 ) HTML (35 KB) PDF (0 KB) ( 8 )

	62	Effect of Levetiracetam on adult patients with refractory epilepsy and immune function
		SHANG Xiao-lin
		Objective To explore the effect of Levetiracetam on partial seizures in adults with refractory epilepsy,and its effect on the immune function of patients.Methods A total of 80 adult patients with refractory epilepsy who were admitted to Liaoning Health Industry Group Iron Coal General Hospital from January 2017 to January 2019 were selected as the research subjects.They were divided into the experimental group (40 cases) and the control group (40 cases) by random number table method.The control group was given oral Topiramate and Carbamazepine,and the experimental group was given Levetiracetam on the basis of the control group.Both groups were treated for 6 months.The effect of treatment,changes of immune function indexes before and after treatment and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 72.50%,which was higher than 47.50% of the control group,and the difference was statistically significant (P＜0.05).After treatment,the levels of IgA,IgG and IgM in the two groups were higher than before,and the levels of IgA,IgG and IgM in the experimental group were higher than those in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in T cell subsets in the control group before and after treatment (P＞0.05).After treatment,the levels of CD3+ and CD4+ in the experimental group were higher than before treatment,the level of CD8+ was lower than before treatment,and the levels of CD3+ and CD4+ in the experimental group were higher than those of the control group and the level of CD8+ was lower than that of the control group,the differences were statistically significant (P＜0.05).Conclusion The efficacy of Levetiracetam in the treatment of refractory epilepsy in adults is definite and can significantly improve the immune function of patients,which is worthy of clinical application.
		2021 Vol. 28 (9): 62-64 [Abstract] ( 49 ) HTML (31 KB) PDF (0 KB) ( 7 )

	65	Analysis of the significance and value of procalcitonin in the early diagnosis and prognosis prediction of critical patients complicated with sepsis
		LUO Ji
		Objective To investigate the significance and value of procalcitonin in the early diagnosis and prognosis prediction of critical patients complicated with sepsis.Methods A total of 90 patients with systemic inflammatory response syndrome admitted to Liaoning Health Industry Group Fukuang General Hospital from November 2018 to February 2020 were selected.According to their clinical symptoms,the patients were divided into sepsis group (45 cases) and non-sepsis group (45 cases).Among the sepsis patients,35 patients survived and were set as the survival group.Ten patients died and were assigned to the death group.The levels of procalcitonin (PCT),C-reactive protein(CRP) and white blood cells (WBC),acute physiology and chronic health (APACHE Ⅱ) score in sepsis group and nonsepsis group,death group and survival group were compared.Results There were no significant differences in WBC count and CRP level between the sepsis group and the non-sepsis group on the first and third day of admission (P＞0.05).The PCT level and APACHE Ⅱscore of sepsis group were higher than those of the non-sepsis group on the first and third day of admission,the differences were statistically significant (P＜0.05).The PCT level and APACHE Ⅱscore of two groups on the third day of admission were lower than those on the first day of admission,the differences were statistically significant (P＜0.05).There were no significant differences in WBC count and CRP level between the death group and the survival group (P＞0.05).The PCT level,APACHE Ⅱscore of death group were higher than those of the survival group,the differences were statistically significant (P＜0.05).The area under curve (AUC) and 95% CI of PCT levels to predict patients′ death were higher than those of the APACHE Ⅱscore,and the critical value is lower than the APACHE Ⅱscore,the differences were statistically significant (P＜0.05).Conclusion The use of procalcitonin in the early diagnosis and prognosis of critical patients with sepsis has high accuracy and high clinical application value.
		2021 Vol. 28 (9): 65-67转71 [Abstract] ( 41 ) HTML (32 KB) PDF (0 KB) ( 6 )

	68	Effects of full femtosecond small incision lens extraction and femtosecond laser flap LASIK in patients with ametropia
		ZHANG Rui ;ZHANG Qiao-si; LIANG-Wei ;YU Chun-jing
		Objective To investigate the clinical effect of femtosecond small incision lens removal and femtosecond laser in situ keratomileusis (LASIK) in the treatment of patients with ametropia.Methods A total of 80 patients (160 eyes) with ametropia who underwent preoperative correction in the Third People′s Hospital of Dalian from May 2018 to May 2019 were selected as the research subjects.According to random number table method,they were divided into observation group (40 cases) and control group (40 cases).The observation group received full femtosecond small incision lens removal (SMILE) surgery,and the control group received LASIK surgery.The follow-up period was 1 year.The corneal endothelial cell density,corneal perceptual ocular surface disease index (OSDI) score,intraocular pressure and visual acuity changes,and the incidence of complications were compared between the two groups before and after surgery.Results One year after operation,the density of corneal endothelial cells in the observation group was higher than that in the control group,the difference was statistically significant (P＜0.05).The OSDI score of the observation group was higher than that of the postoperative control group,the difference was statistically significant (P＜0.05).The intraocular pressure of the observation group was lower than that of the control group,and the visual acuity of the observation group was higher than that of the control group after the operation and one year after the operation,the differences were statistically significant (P＜0.05).The incidence of postoperative complications in the observation group was lower than that in the control group,with statistical significance (P＜0.05).Conclusion Full femtosecond SMILE surgery can effectively promote the recovery of corneal function and improve visual acuity,with fewer complications and high safety.
		2021 Vol. 28 (9): 68-71 [Abstract] ( 49 ) HTML (33 KB) PDF (0 KB) ( 7 )

	72	Application of nutritional software of traditional Chinese medicine combining with Western medicine in improving the nutritional status of patients with diabetic nephropathy
		QIN Yu-xia; FU Chuan-cui ;WU Wen-bin
		Objective To explore the effect of nutritional software of traditional Chinese medicine combining with Western medicine (NCCW) in improving the nutritional status of patients with diabetic nephropathy.Methods A total of 100 patients with diabetic nephropathy in the outpatient and inpatient clinics of Yidu Central Hospital in Weifang City from March to September 2019 were selected as the research subjects,and they were divided into the observation group and the control group according to random number table methods,50 cases in each group.Two groups of patients were given the same drug treatment,the observation group was given NCCW diet intervention on this basis.After 14 weeks,the improvement of serum total protein (TP),albumin (Alb),prealbumin (PA),transferrin (TRF),body weight,body protein and body cell mass were compared between the two groups.Results The nutritional indexes of TP,Alb,PA,TRF and body weight,body protein and body cell mass in the analysis report of body composition of the two groups after dietary intervention were higher than those before intervention,the differences were statistically significant (P＜0.05).After intervention,the levels of TP,Alb,TRF,PA,body weight,body protein and body cell mass quantity of the observation group were higher than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion NCCW adjuvant therapy can improve the nutritional status of patients with diabetic nephropathy.
		2021 Vol. 28 (9): 72-74转78 [Abstract] ( 51 ) HTML (31 KB) PDF (0 KB) ( 8 )

	75	Influence of real-time continuous glucose monitoring on blood glucose intervention effect in patients with diabetes mellitus
		SONG Le-qin; LIN Shao-zhi; LIU Bing-guo; GUO Min ;MA Li-min; LI Xian-cai
		Objective To investigate the influence of real-time continuous glucose monitoring (CGM) on blood glucose intervention effect in patients with diabetes mellitus.Methods A total of 240 patients with diabetes mellitus who were hospitalized in Weifang Endocrine and Metabolic Hospital from February 2018 to May 2020 were selected as study subjects,and they were divided into the control group(n=120)and the observation group(n=120)by random number table method.Patients in both groups were given routine treatment of diabetes,including diet and exercise guidance,insulin injection,HbA1c detection,and wearing CGM for 4 days.The control group was given routine intervention,and the observation group was given targeted intervention according to CGM results.HbA1c level was detected again and CGM was worn for 4 days after 12 weeks.The blood glucose standard deviation(SD),mean amplitude of glycemic excursions(MAGE),mean blood glucose level (MG),fasting blood glucose (FBG),2 h blood glucose after breakfast (2 h BG),time of hyperglycemia,time of blood glucose ＞3.9 mmol/L and ＜10.0 mmol/L (TIR),time of hypoglycemia and HbA1c level were compared between the two groups.Results There were no significant differences in SD,MAGE,MG,FBG,2 h BG after breakfast,time of hyperglycemia,TIR,time of hypoglycemia and HbA1c between the two groups before intervention (P ＞0.05).There were no significant differences in SD,MAGE,MG,FBG,2 h BG after breakfast,time of hyperglycemia,TIR,time of hypoglycemia and HbA1c of the control group between after intervention and before intervention (P＞0.05).MAGE and 2 h BG after breakfast in the observation group after intervention were significantly lower than those in the control group,and TIR in the observation group after intervention was significantly longer than that in the control group,and the differences were statistically significant (P＜0.05).After intervention,the levels of MG,FBG and HbA1c in the observation group were lower than those in the control group,and the time of hyperglycemia in the observation group was shorter than that in the control group,and the differences were statistically significant (P＜0.05).There were no significant differences in SD and the time of hypoglycemia between the two groups (P＞0.05).The levels of MAGE,2 h BG after breakfast in the observation group after intervention were significantly lower than those before intervention,and TIR in the observation group after intervention was significantly longer than that before intervention,and the differences were statistically significant(P＜0.05).The levels of MG,FBG and the time of hyperglycemia in the observation groups after intervention were shorter than those before intervention,and the level of HbA1c in the observation group after intervention was lower than that before intervention,and the differences were statistically significant (P＜0.05).There were no significant difference in SD and the time of hypoglycemia in the observation group after intervention and before intervention (P＞0.05).Conclusion Real-time CGM can reflect the changes of blood glucose in the blood glucose monitoring of diabetic patients.Through targeted intervention,blood glucose can be significantly reduced,fluctuation of blood glucose can be reduced,which can provide basis for clinical treatment and care.
		2021 Vol. 28 (9): 75-78 [Abstract] ( 44 ) HTML (33 KB) PDF (0 KB) ( 6 )

	79	Analysis on risk factors of anastomotic fistula after rectal cancer surgery
		GENG Xuan ;ZHU You-long▲; ZHANG Min-kang; XIA Hong
		Objective To study the risk factors of anastomotic fistula after rectal cancer surgery.Methods The clinical data of 756 patients diagnosed with rectal cancer from January 2015 to December 2019 in the Gastrointestinal Surgery Department of Xuzhou Central Hospital were analyzed retrospectively.Among them,155 cases underwent abdominal perineal excision of rectal cancer (MILES surgery),39 cases underwent Hartmann surgery,and the remaining 562 cases underwent radical resection of rectal cancer (anterior resection of rectal cancer) were included in the study.Among them,there were 292 males and 270 females aged 35-91 years old,with a median age of 66 years old.Related risk factors included gender,age,intestinal obstruction,diabetes,preoperative hemoglobin level,preoperative albumin level,preoperative neoadjuvant chemotherapy,surgery time,distance from the tumor to the anal margin,laparoscopic surgery,intraoperative left colon vascular injury and intraoperative infusion of chemotherapy drugs.Results Altogether 39 of 562 surgical patients suffered from anastomotic fistula,with the incidence of 6.9%.The occurrence of anastomotic fistula after rectal cancer surgery was related to age,intestinal obstruction,preoperative albumin level,distance from the tumor to the anal margin and intraoperative left colon vascular injury (P＜0.05).The advanced age,intestinal obstruction,low preoperative albumin level and short distance from the tumor to the anal margin were independent risk factors for anastomotic fistula (P＜0.05).Conclusion The occurrence of anastomotic fistula in radical resection of rectal cancer is related to many factors such as age,intestinal obstruction,preoperative albumin level and distance from the tumor to the anal margin.
		2021 Vol. 28 (9): 79-81 [Abstract] ( 48 ) HTML (29 KB) PDF (0 KB) ( 7 )

	82	Effect of laparoscopy combined with choledochoscopy for common bile duct exploration in the treatment of patients with recurrent common bile duct stones and its influence on the body′s stress response
		HONG Xiao-cheng; LIN Shu-wen ;YE Wei-jie ;CHEN Jia-yang ;JI Cheng-gang
		Objective To explore the effect of laparoscopy combined with choledochoscopy for common bile duct exploration in the treatment of patients with recurrent common bile duct stones and its influence on the body′s stress response.Methods A total of 40 patients with recurrent common bile duct stones admitted to Dongguan Marina Bay Center Hospital from December 2015 to October 2019 were selected as the research objects,and they were divided into two groups according to the random number table method,the control group (n=20) and the observation group (n=20).The control group underwent traditional open surgery,and the observation group underwent laparoscopy combined with choledochoscopy for common bile duct exploration.The surgical efficacy,stress response and incidence of complications of patients in the two groups were observed.Results The success rate of stone retrieval and stone removal rate in the observation group were higher than those in the control group,and the stone recurrence rate was lower than that in the control group,the differences were statistically significant (P＜0.05).There were no significant differences in the levels of cortisol,angiotensin Ⅱand norepinephrine between the two groups before operation (P＞0.05).The stress response index levels of the two groups at 3 days after operation were lower than those of this group before operation,the differences were statistically significant (P＜0.05).The stress response index levels in the observation group at 3 days after operation were lower than those in the control group,the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group was lower than that in the control group (15.00% vs.45.00%),and the difference was statistically significant (P＜0.05).Conclusion Laparoscopy combined with choledochoscopy for common bile duct exploration in patients with recurrent common bile duct stones can improve the surgical efficacy and reduce the stress response of the patients,and the patients have fewer complications,which is worthy of clinical promotion.
		2021 Vol. 28 (9): 82-84转88 [Abstract] ( 55 ) HTML (31 KB) PDF (0 KB) ( 7 )

	85	Effect of early laparoscopic cholecystectomy in the treatment of biliary pancreatitis
		WANG Hao; FAN Yong-wei▲
		Objective To analyze the effect of early laparoscopic cholecystectomy in the treatment of biliary pancreatitis.Methods The 88 patients with biliary pancreatitis who were admitted to the the Second People′s Hospital and Gynecology and Obstetrics Hospital of Fuxin City from January 2017 to October 2019 were enrolled as the research subjects.According to their treatment willingness,they were divided into the study group (n=44,early laparoscopic cholecystectomy) and the control group (n=44,delayed laparoscopic cholecystectomy).The total effective rate of treatment,surgical indicators,incidence of complications,and the serum alanine aminotransferase (ALT),aspartate aminotransferase (AST) and alkaline phosphatase (AKP) levels at different time periods after surgery were compared in the two groups.Results The total effective rate of treatment in the study group was 97.73%,higher than that in the control group accounting for 79.55%,with statistical significance (P＜0.05).There were no significant differences in the operation time and postoperative anal exhaust time between the two groups (P＞0.05).Compared with one day after operation,the levels of ALT,AST and AKP at three and seven days after the operation in the two groups increased first and then decreased,but without significant differences at each time period between the two groups in the levels of ALT,AST and AKP (P＞0.05).The hospitalization cost of the study group was less than that of the control group,and hospital stay was shorter than that of the control group,and the total incidence of complications of the study group was 6.82%,lower than that of the control group accounting for 25.00%,with statistical significances (P＜0.05).Conclusion Early laparoscopic cholecystectomy is effective in the treatment of biliary pancreatitis,which can shorten the hospital stay,reduce hospitalization cost and the incidence of complications.
		2021 Vol. 28 (9): 85-88 [Abstract] ( 37 ) HTML (36 KB) PDF (0 KB) ( 7 )

	89	Clinical effect of laparoscopic splenectomy combined with pericardial vessel dissection in the treatment of portal hypertension of liver cirrhosis
		ZHOU Xin-qi ;XU Feng ;ZHANG Qi-min
		]Objective To investigate the clinical effect of laparoscopic splenectomy combined with pericardial vascular dissection in the treatment of portal hypertension of liver cirrhosis.Methods From January 2018 to January 2019,54 patients with portal hypertension of liver cirrhosis were selected as the research objects,and they were divided into the experimental group (27 cases,laparoscopic splenectomy+pericardial vascular dissection) and the control group (27 cases,open splenectomy+pericardial vascular dissection) according to the random number table method.The surgical success rate and incidence of complications of the two groups were statistically analyzed,and the basic operation indexes and improvement of esophageal and gastric varices of the two groups were observed to evaluate the efficacy and safety.Results Both groups successfully completed the operation,with a success rate of 100%.The total incidence of complications in the experimental group (7.41%) was lower than that in the control group (25.93%),the intraoperative blood loss ([325.8±74.2]mL) was less than that of the control group ([453.0±91.6]mL),the first exhaust time ([1.4±0.3]d)was shorter than that of the control group ([2.7±0.5]d),and the differences were statistically significant (χ2=6.814,t=7.614,3.196,P＜0.05).After electronic gastroscopy,esophageal and gastric varices improved or disappeared in different degrees in the two groups.No upper gastrointestinal bleeding occurred during the follow-up of 1 year.The effective rate of treatment was 100%.Conclusion Laparoscopic splenectomy combined with pericardial vascular dissection can effectively improve the symptoms of esophagogastric varices and prevent upper gastrointestinal bleeding,which can achieve the same effect as open surgery in the treatment of cirrhotic portal hypertension,with fewer complications,faster postoperative recovery and higher clinical promotion value.
		2021 Vol. 28 (9): 89-92 [Abstract] ( 44 ) HTML (36 KB) PDF (0 KB) ( 7 )

	93	Effect of laparoscopic cholecystectomy on gastrointestinal function and inflammatory factor levels in patients with acute cholecystitis
		LI Shuai
		Objective To explore the effect of laparoscopic cholecystectomy (LC) on gastrointestinal function and levels of inflammatory factors in patients with acute cholecystitis.Methods A total of 300 patients with acute cholecystitis admitted to Jinzhou Central Hospital from November 2017 to November 2019 were retrospectively analyzed.According to different surgical methods,they were divided into the control group (145 cases) and the observation group (155 cases).Three-hole LC was used in the control group,and in the observation group,single-hole LC was adopted.The perioperative indicators,gastrointestinal function and changes of inflammatory factors mainly including C-reactive protein(CRP),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) before surgery and 3 days after surgery,and complications of the two groups were compared.Results The operation time,exhaust time and hospital stay of the observation group were shorter than those of the control group,and the bleeding volume during operation was less than that of the control group,the differences were statistically significant (P＜0.05).The recovery time of bowel sounds,food ingestion time and defecation time in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The levels of CRP,TNF-α and IL-6 3 days after surgery were lower than those before operation,and the levels of CRP,TNF-α and IL-6 in the observation group were lower than the control group at 3 days after surgery,and the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group was lower than the control group,and the difference was statistically significant (P＜0.05).Conclusion The effect of single-hole LC in patients with acute cholecystitis is favorable,which can significantly reduce the operation time and hospital stay,improve gastrointestinal function and the levels of inflammatory factors,decrease postoperative complications,and faciliate the prognosis of patients.It is worthy of clinical promotion.
		2021 Vol. 28 (9): 93-95转99 [Abstract] ( 50 ) HTML (31 KB) PDF (0 KB) ( 4 )

	96	Application of laparoscopy combined with choledochoscopy in patients with cholecystolithiasis
		MA Chi ;JIA You-peng▲
		Objective To explore the application value of laparoscopy combined with choledochoscopy in patients with cholecystolithiasis.Methods The clinical data of 80 patients with cholecystolithiasis treated in Dalian Central Hospital from January 2017 to December 2019 were retrospectively collected.The data of 37 patients who underwent laparoscopic calculus clearance were included in the control group,and the data of 43 patients who underwent laparoscopic combined with choledochoscopy calculus clearance were included in the observation group.The calculus clearance rate,perioperative index,gastrointestinal function,gallbladder contraction rate and total incidence of complications were compared between the two groups.Results The calculus clearance rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).There were no significant differences between the two groups in total operation time,intraoperative bleeding volume and total hospitalization time (P＞0.05).The recovery time of each index of gastrointestinal function in the observation group (the time it took for the first exhaust of the anus,the first defecation,and the recovery of bowel sounds) were shorter than those of the control group,and the differences were statistically significant (P＜0.05).Compared the the gallbladder contraction rate in the observation group before and 3 months after operation,the difference was not statistically significant (P＞0.05).The gallbladder contraction rate of the control group 3 months after operation was lower than that before operation,the difference was statistically significant (P＜0.05).The gallbladder contraction rate of the observation group was higher than that of the control group 3 months after operation,and the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of complications between the two groups (P＞0.05).Conclusion The application of laparoscopy combined with choledochoscopy in patients with cholecystolithiasis can increase the calculus clearance rate,promote the recovery of gastrointestinal function after surgery,and reduce the impact on the gallbladder contractile function,which has high safety and fewer complications.
		2021 Vol. 28 (9): 96-99 [Abstract] ( 46 ) HTML (35 KB) PDF (0 KB) ( 9 )

	100	The value of ultrasonic monitoring in the treatment of hysteroscopic adhesiotomy
		QI Hong-ming
		Objective To investigate the effect of ultrasound monitoring in hysteroscopic electrosurgical treatment of adhesions in patients with uterine adhesions syndrome.Methods From December 2017 to December 2019,a total of 100 patients with uterine adhesions syndrome were enrolled in the Minimally Invasive Department of Dandong Central Hospital of Liaoning Province.They were divided into control group (n=50) and observation group (n=50) by computer numbering.The control group was treated by hysteroscopic adhesions resection,while the observation group was treated by hysteroscopic adhesions resection combined with ultrasound monitoring.Normal menstruation rate before and after treatment,incidence of menstrual period with periodic lower abdominal pain,and treatment data (operation time,intraoperative bleeding volume,length of hospital stay,uterine adhesiotomy time) were compared between two groups.Results There were no significant differences in the normal menstruation rate and the incidence of menstrual period with periodic lower abdominal pain between the two groups before treatment (P ＞0.05).After treatment,the normal menstruation rate and the incidence of menstrual period with periodic lower abdominal pain in both groups improved than before treatment,the normal menstruation rate in the observation group was higher than that in the control group,and the incidence of menstrual period with periodic lower abdominal pain was lower than that in the control group,the differences were statistically significant (P＜0.05).The operation time,hospitalization time and incision time of uterine adhesions in the observation group were (12.66±3.55) min,(3.60±0.70) d and (6.24±0.76) min,which were shorter than those in the control group(15.54±3.57)min,(5.70±0.50)d and(8.66±0.78)min,the amount of intraoperative bleeding in the observation group was (12.89±2.48) mL,which was less than that in the control group (16.22±3.12) mL,the differences were statistically significant (P＜0.05).Conclusion Ultrasound monitoring combined with hysteroscopic electrosurgical treatment of uterine adhesions in patients with syndromes of uterine adhesions,which can effectively shorten the operation time and hospitalization time,is conducive to the rehabilitation of patients,and is worthy of vigorous promotion and application.
		2021 Vol. 28 (9): 100-102 [Abstract] ( 40 ) HTML (30 KB) PDF (0 KB) ( 6 )

	103	Effect of Ethinyl Estradiol and Cyproterone Tablets combined with Metformin and Rosiglitazone on outcomes of in vitro fertilization embryo transfer in patients with polycystic ovary syndrome
		LIU Bei-mei
		Objective To explore the effect of Ethinyl Estradiol and Cyproterone Tablets combined with Metformin and Rosiglitazone on the outcomes of in vitro fertilization embryo transfer in patients with polycystic ovary syndrome.Methods A total of 135 patients with polycystic ovary syndrome who received in vitro fertilization embryo transfer treatment in Jieyang IVF Hospital from October 2016 to October 2018 were selected and divided into group A (45 patients),group B (45 patients) and group C (45 patients) by the random number table method.Group A were treated with Ethinyl Estradiol and Cyproterone Tablets,group B were treated with Ethinyl Estradiol and Cyproterone Tablets combined with Metformin,and group C were treated with Ethinyl Estradiol and Cyproterone Tablets combined with Rosiglitazone.The effect on the outcomes of in vitro fertilization embryo transfer,body weight before and after treatment,body mass index(BMI),sex hormone levels before and after treatment,and embryo implantation rate were compared among the three groups.Results The cycle cancellation rate in group A was higher than that in group B and C,with statistically significant differences (P＜0.05).There were no statistically significant differences of the incidence rates of ovarian hyperstimulation syndrome (OHSS) among the three groups (P＞0.05).The pregnancy rate of group C was higher than that of group A and B,with statistically significant differences (P＜0.05).There were no statistically significant differences of the abortion rates among the three groups (P＞0.05).The body weight and BMI in group A and B were lower than those before treatment,with statistically significant differences (P＜0.05);after treatment,the weight of patients in group A was higher than that of group B,and lower than that of group C,with statistically significant differences (P＜0.05);there were no significant differences in body weight and BMI in group C before and after treatment (P＞0.05).The levels of testosterone (T),luteinizing hormone (LH) in the three groups after treatment were lower than those before treatment,with statistically significant differences (P＜0.05);there were no statistically significant differences on the levels of T and LH among three groups after treatment(P＞0.05).The embryo implantation rate of group C was higher than that of group A and B,with statistically significant differences(P＜0.05).Conclusion Ethinyl Estradiol and Cyproterone Tablets combined with Metformin and Rosiglitazone effectively improves hormone levels and the outcomes of in vitro fertilization embryo transfer in patients with polycystic ovary syndrome.
		2021 Vol. 28 (9): 103-106转110 [Abstract] ( 48 ) HTML (36 KB) PDF (0 KB) ( 5 )

	107	Application of gonadotropin-releasing hormone analogues in girls with idiopathic central precocious puberty
		LIN Xue-xia; XU Xian; REN Lan-xian
		Objective To explore the application of gonadotropin-releasing hormone analogue (GnRHa) in girls with idiopathic central precocious puberty (ICPP).Methods Retrospective analysis was performed on the clinical data of 350 cases of ICPP girls treated with GnRHa in Yangjiang Maternal and Child Health Hospital from March 2015 to March 2020,and the changes of body mass index (BMI),bone age,adiponectin (ADPN) and thyroid function (free tri-iodothyronine [FT3],free thyroxine [FT4],thyroid stimulating hormone [TSH]) were compared among before and after 3 months of treatment,and 6 months after treatment.Results After 3 months of treatment and 6 months of treatment,the BMI indexes were lower than those before treatment,the differences were statistically significant (P＜0.05);the difference of BMI between after 3 months of treatment and after 6 months of treatment was not statistically significant (P＞0.05).There was no significant difference in bone age at different times among before treatment,after 3 months of treatment and after 6 months of treatment (P＞0.05).After 3 months of treatment and after 6 months of treatment,the levels of ADPN were higher than those before treatment,the level of ADPN after 6 months of treatment was higher than that after 3 months of treatment,the differences were statistically significant(P＜0.05).After 3 months of treatment and 6 months of treatment,the levels of FT3 were higher than those before treatment,the level of FT3 after 6 months of treatment was lower than that after 3 months of treatment,the differences were statistically significant (P＜0.05).After 3 months of treatment,the level of FT4 was higher than that before treatment,the level of FT4 after 6 months of treatment was lower than that after 3 months of treatment,the differences were statistically significant (P＜0.05);there was no statistically significant difference in FT4 levels after 6 months of treatment and before treatment (P ＞0.05).The TSH level after 3 months of treatment was higher than that before treatment,and the TSH level after 6 months of treatment was lower than those after 3 months of treatment and before treatment,the differences were statistically significant (P＜0.05).Conclusion During the treating of GnRHa for ICPP in girls,ADPN is significantly increasing and BMI and thyroid function gradually returning to normal.
		2021 Vol. 28 (9): 107-110 [Abstract] ( 44 ) HTML (34 KB) PDF (0 KB) ( 7 )

	111	Effect of non-nutritive sucking combined with three-step prone position on feeding intolerance of premature infants
		HE Li-hong; LIAO Shui-xian; HE Sha-sha
		Objective To explore the effect of non-nutritive sucking combined with three-step prone position intervention in premature infants with feeding intolerance.Methods A total of 60 cases of premature infants with feeding intolerance admitted to Yingde People′s Hospital from February 2018 to June 2020 were retrospectively analyzed.Among them,30 children admitted from February 2018 to August 2019 who did not perform non-nutritive sucking combined with three-step prone intervention were the control group,and another 30 children admitted from September 2019 to June 2020 who performed non-nutritive sucking combined with three-step prone position intervention were the study group.The symptoms of feeding intolerance,feeding indexes,hospitalization time,growth and development indexes were compared between the two groups.Results The incidence of vomiting,abdominal distention,apnea and gastric retention in the study group of 6.67%,3.33%,3.33%,10.00%,respectively,lower than those in the observation group of 26.67%,30.00%,26.67%,33.33%,and the time of opening the milk,the time of reaching the total enteral feeding time and the time of stay were all shorter than those in the control group,birth weight,head circumference at the 14th day were all higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Non-nutritive sucking combined with three-step prone position can improve the feeding intolerance symptoms of preterm infants,promote gastrointestinal functional maturity,improve feeding status,promote their growth and development,shorten the hospitalization time and benefit the prognosis of children.
		2021 Vol. 28 (9): 111-113 [Abstract] ( 38 ) HTML (30 KB) PDF (0 KB) ( 7 )

	114	Clinical application effect of Fuke Qianjin Capsules combined with Desogestrel and Ethinylestradiol Tablets in patients after abortion surgery
		ZHOU Xiao-yan
		Objective To explore the clinical application effect of Fuke Qianjin Capsules combined with Desogestrel and Ethinylestradiol Tablets after abortion surgery.Methods A total of 74 patients who underwent abortion operation in Xiezhuang coal mine hospital Xinwen mining group from September 2018 to April 2020 were selected.According to the touch ball method,the patients were divided into control group (37 cases) and observation group (37 cases).The patients in control group were treated with Desogestrel and Ethinylestradiol Tablets,and the patients in observation group were treated with Fuke Qianjin Capsules combined with Desogestrel and Ethinylestradiol Tablets.The amount of vaginal bleeding,vaginal bleeding and menstrual recovery time,endometrial thickness and complications were compared between the two groups.Results Compared with the control group,the observation group had less vaginal bleeding,shorter vaginal bleeding time and menstrual recovery time,thinner endometrial thickness and lower complication rate,all differences were statistically significant (P＜0.05).Conclusion The combination of Fuke Qianjin Capsules and Desogestrel and Ethinylestradiol Tablets can effectively improve the prognosis of patients undergoing abortion,promote recovery,and promote the patients′ menstrual cycle to accelerate the reconstruction.It is worthy of promotion.
		2021 Vol. 28 (9): 114-116 [Abstract] ( 58 ) HTML (30 KB) PDF (0 KB) ( 6 )

	117	Cerebral protective effect of Sevoflurane on controlled blood pressure reduction in patients with coronary heart disease undergoing craniocerebral surgery
		ZHANG Hua-peng ;ZHANG Sai-yu ;CHEN Hua-yong▲
		Objective To study the cerebral protective effect of Sevoflurane on controlled blood pressure reduction in patients with coronary heart disease undergoing craniocerebral surgery.Methods Fifty-two patients with coronary heart disease (CHD) who underwent cranial surgery in Yidu Central Hospital of Weifang City in Shandong Province from January 2019 to May 2020 were selected as the research objects,and they were divided into experimental group and reference group according to random number table method,with 26 cases in each group.All patients underwent controlled blood pressure reduction after opening the dura mater.The experimental group was given Sevoflurane combined inhalation,and the control group was given Sodium Nitroprusside intravenous pump.The levels of S100 calcium binding protein β (S-100β protein),neuron-specific enolase (NSE),creatine kinase isoenzyme (CK-MB),troponin I (TnI)before and after surgery were compared between the two groups,and the incidence of postoperative complications was compared between the two groups.Results There were no significant differences in the levels of CK-MB and TnI between the two groups before and after operation (P＞0.05).The levels of CK-MB and TnI in the two groups after surgery were higher than those before surgery,and the differences were statistically significant (P＜0.05).The levels of serum NSE and S-100β protein in experimental group after operation were lower than those in control group,and the differences were statistically significant (P＜0.05).The levels of serum NSE and S-100β protein in the two groups after operation were higher than those before operation,and the differences were statistically significant (P＜0.05).The incidence of postoperative complications in experimental group was lower than that in control group,and the difference was statistically significant (P＜0.05).Conclusion Sevoflurane can effectively protect the brain tissue by controlling blood pressure reduction in patients with coronary heart disease during craniocerebral surgery,which can be used for further research.
		2021 Vol. 28 (9): 117-120 [Abstract] ( 42 ) HTML (36 KB) PDF (0 KB) ( 7 )

	121	Application of narcotic analgesic drug Nalbuphine Hydrochloride in painless gastroscopy
		DAI Jian-zhong; LIU Yan-ling ;XU Jia-ji
		Objective To observe the application of narcotic analgesic drug Nabuphine Hydrochloride in painless gastroscopy.Methods A total of 100 patients who planned to undergo painless gastroscopy in the Outpatient Clinic of Fengtai You′anmen Hospital of Beijing from January to October 2019 were selected as the research subjects,and they were divided into two groups according to random number table method,with 50 patients in each group.Group A was analgesic with Propofol combined with Nalbuphine Hydrochloride.Group B was anaesthetised with Propofol.The mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthesia (T0),gastroscope insertion (T1),gastroscope withdrawn (T2),and 15 min after the operation (T3).Besides,the operation time,awakening time,Propofol dose,and incidence of adverse reactions were recorded.Results MBP and HR of two groups at T1 and T2 were lower than those at T0,the differences were statistically significant (P＜0.05).At T1 and T2,MBP levels in group A were higher than those in group B,and the differences were statistically significant (P＜0.05).At T2,the HR level of group A was higher than that of group B,and the difference was statistically significant (P＜0.05).The time of awakening in group A was shorter than that in group B,and the amount of propofol was less than that in group B,with statistical significances (P＜0.05).There was no statistical significance in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion In painless gastroscopy,the combined application of Nalbuphine Hydrochloride has stable circulation,quick awakening from anesthesia,and low incidence of adverse reactions.It is a good medication choice.
		2021 Vol. 28 (9): 121-124 [Abstract] ( 57 ) HTML (41 KB) PDF (0 KB) ( 6 )

	125	Effect of intensive lipid-lowering on acute cerebral infarction and its influence on the level of serum inflammatory factors in patients
		WANG Xiao-han
		Objective To investigate the application effect of intensive lipid-lowering in patients with acute cerebral infarction (ACI).Methods Eighty-five patients with ACI who were treated in the Liaoyang Central Hospital from June 2018 to June 2019 were selected as the research subjects for retrospective analysis.Forty-two patients treated with conventional treatment plus conventional dose of Atorvastatin were included in a control group,43 patients who received conventional treatment plus intensive lipid-lowering were included in an observation group.Both groups were treated continuously for four weeks.The clinical effect of the two groups was compared,and the serum inflammatory factors and blood lipid levels were observed.Results The total effective efficiency of observation group (95.35%) was higher than that of control group (78.57%),and the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in the levels of C-reactive protein (CRP),total cholesterol (TC) and triglyceride (TG) between the two groups (P＞0.05).After 4 weeks of treatment,the levels of CRP,TC and TG in the two groups were lower than those before treatment,and the levels of CRP,TC and TG in observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Intensive lipid-lowering therapy is effective for patients with ACI,which is beneficial to alleviate the inflammatory response,lower blood lipid levels and improve clinical efficacy.
		2021 Vol. 28 (9): 125-127 [Abstract] ( 51 ) HTML (31 KB) PDF (0 KB) ( 6 )

	128	Study on bioequivalence of Captopril Tablets under fasting condition
		NIE Chang-sheng;ZHAO Xiang;CUI Jing;CHEN Ren-yan
		Objective To evaluate the bioequivalence between the test preparation of Captopril Tablets produced by Renhetang Pharmaceutical Co.,Ltd.and the reference preparation produced by Bristol-Myers Squibb S.r.l.To provide basis for rational drug use in clinic.Methods A total of 24 healthy adult Chinese subjects enrolled in Zhengzhou Central Hospital from September to November 2019 to study the bioequivalence of the test preparation and reference preparation of Captopril Tablets.A randomized,single-dose,two-preparation,two-period,crossover experiment design was used,and they were divided into the R-T group and T-R group according to random number table method,with 12 subjects in each group.Under fasting condition,R-T group was given single dose of test preparation and reference preparation of Captopril Tablets orally,and T-R group was given single dose of reference preparation and test preparation of Captopril Tablets orally.Two cycles of cross-medication were conducted to obtain 24 samples of test preparation and reference preparation respectively.The test preparation and reference preparation of single dose Captopril Tablets were taken orally under fasting condition.All the data were analyzed by SAS 9.4 software,and the bioequivalence of the two preparations was evaluated.Results The intraspecific variation (CV%) for Cmax,AUC0-t and AUC0-∞of test preparation and reference preparation were below 30%,90%CI of geometric mean point estimate for Cmax,AUC0-t and AUC0-∞of test preparation and reference preparation were 87.82%-100.74%,91.37%-101.35% and 91.47%-101.33%,respectively.All of them were in the range of 80.00%-125.00%,which met the criteria of bioequivalence.Conclusion The test preparation and reference preparation of Captopril Tablets are bioequivalent.
		2021 Vol. 28 (9): 128-130 [Abstract] ( 36 ) HTML (32 KB) PDF (0 KB) ( 8 )

	131	Analysis of thecervical high risk humanpapillomavirus infection status and subtype distribution in Shenyang
		CHEN Xiao-dan; MENG Fei;WU Xin▲
		Objective To analyze the cervical high risk human papillomavirus (HPV) infection status and subtype distribution in 698 women in the region of Shenyang.Methods A total of 698 patients who underwent HPV-DNA typing in the Department of Gynecology of the First Affiliated Hospital of China Medical University from May 2017 to October 2019 were selected as the research subjects.The HPV detection rate and infection subtypes of different lesion types were compared.Results The total positive rate of HPV in cervical lesions was 61.90%,and the positive rate gradually increased with the increase of cervical lesions.The common subtypes of HPV infection in women with cervical lesions in Shenyang area were HPV16,33,58,53,52,18 and 31.HPV33 was one of the main of HPV infection in Shenyang,more common in cervical intraepithelial neoplasia and Ⅲlevel (CINⅢ).HPV53 was one of the main of HPV infection in Shenyang,more common in cervicitis,cervical intraepithelial neoplasia and grade I (CIN Ⅰ) and normal cervix.Conclusion The common HPV infection subtypes in cervical lesions in Shenyang population were HPV16,33,58,53,52,18,31.
		2021 Vol. 28 (9): 131-134转138 [Abstract] ( 43 ) HTML (33 KB) PDF (0 KB) ( 7 )

	135	Analysis of the influencing factors of recurrence after erabdication of helicobacter pylori inpatients with type 2 diabetes
		ZHU Lin; FAN Shu-ling;WANG Zhen;HU Shan
		Objective To investigate the related factors of helicobacter pylori (HP) recurrence after eradication in patients with type 2 diabetic (T2DM).Methods A total of 132 patients with type 2 diabetes who were confirmed to be Hp positive by13C urea breath test in Guangxin People′s Hospital of Shangrao City,Jiangxi Province from January 2018 to April 2019 were selected as the research subjects.All patients were negative on13C urea breath test 4 weeks after Hp eradication with standard quadruple regimen and completed the questionnaires.13C urea breath test was performed at 6 months and 12 months.The basic data of Hp positive and Hp negative patients were compared.Results The recurrence rate of HP in 132 patients was 10.61% (14/132) after 6 months of withdrawal.After 12 months of withdrawal,4 patients lost their HP due to their refusal to follow up,and the recurrence rate of HP was 13.16% (15/114).The course of disease,infection rate of other family members and HbA1c level of patients with recurrent HP were higher than those without recurrent HP,and the differences were statistically significant (P＜0.05).Logistic multivariate regression analysis showed that long course of disease (β=0.487,OR=1.627,95%CI=1.453-1.823) and infection of other people in the family (β=1.088,OR=0.330,95%CI=0.161-0.673) were risk factors for Hp recurrence in T2DM patients (P＜0.05).Conclusion The long course of disease and the infection of others in the family are the risk factors for the recurrence of Hp after eradication in type 2 diabetic patients.It is recommended that for patients with T2DM with a long course of disease,family members should jointly test for and eradicate HP.
		2021 Vol. 28 (9): 135-138 [Abstract] ( 47 ) HTML (33 KB) PDF (0 KB) ( 7 )

	139	Prevalence of anxiety and depression among front-line female medical staff in Beijing
		ZHANG Sai-na;WANG Chun; LI Xiao-hong;TIAN Teng-fei;MENG Fan-qiang;LIU Jun;WANG Yu-juan;ZHANG Qing-e▲
		Objective To investigate the anxiety and depression of female medical staff in Xiaotangshan Designated Hospital and analyze the related influencing factors and provide theoretical basis for maintaining the mental health of front-line female medical staff.Methods Questionnaires were used to study the stress,depression and anxiety and its related influencing factors of the female medical stafffrom April 6 to 10,2020 in Xiaotangshan Designated Hospital.Results A total of 659 female medical staffs were enrolled and completed the questionnaires.There were 396 (60.1%),297 (45.1%) and 126 (19.1%) patients with obvious symptoms of stress,depression and anxiety,respectively.There were 10 (1.5%) patients with symptoms of anxiety and depression.There were 65 (9.9%) and 19 (2.9%) patients had symptoms of moderate to severe depression and anxiety,respectively.Those with large changes in work content,daily time of paying attention to epidemic information＞1 h,and daily sleep time less than 6 h were more likely to experience stress and anxiety symptoms.Large changes in work content,less than 6 hours of sleep per day,and longer anti-epidemic days are more likely to develop depressive symptoms.Conclusion In order to protect the physical and mental health of female health care workers on the front line of the epidemic,it is suggested to reduce the work changes of support staff,arrange appropriate support time and leave,carry out training on disease control knowledge and encourage health care staff to keep moderate exercise.
		2021 Vol. 28 (9): 139-143 [Abstract] ( 49 ) HTML (42 KB) PDF (0 KB) ( 6 )

	144	Application effect of warning-type health education to prevent AIDS
		LIU Da-chuan
		Objective To explore the application effect of warning-type health education to prevent AIDS.Methods A total of 190 non-HIV infected people in Fushun Infections Disease Hospital who were informed of this study from February 2016 to February 2019 were selected as the research objects.Through the intervention of warning health education mode,their understanding of AIDS knowledge before and after the intervention was compared.Results The correct answer to AIDS knowledge after education was higher than that before education,and the difference was statistically significant (P＜0.05);the resistance rate of HIV-infected and AIDS patients after education was lower than that before education,and the difference was statistically significant (P＜0.05).Conclusion Warning-type health education to prevent AIDS is conducive to the further understanding of AIDS knowledge,so as to help them develop the correct habits of making friends and living.
		2021 Vol. 28 (9): 144-146 [Abstract] ( 45 ) HTML (29 KB) PDF (0 KB) ( 6 )

	147	Evaluation on the effect of prevention and control of syphilis and AIDS in Mudanjiang City
		BAI Guang-yu;GAO Jin-xia; ZOU Li-na;RONG Sheng-zhong;ZHOU Yang;JIN Ge;YE Hong-ting▲
		Objective To analyze the effect of prevention and control of syphilis and AIDS in Mudanjiang city.Methods A total of 2000 physical medical examiner without syphilis or AIDS from January 2018 to May 2019 in Mudanjiang City were selected as the research objects,and were divided into the experimental group (n=1000) and the control group (n=1000) by simple randomization method.Conventional management intervention was used in the control group,and health education intervention was used in the experimental group on the basis of control group.The total incidence of infectious diseases (syphilis and AIDS),life satisfaction and degree of disease knowledge mastery were compared between the two groups.Results The total incidence of syphilis and AIDS infectious diseases in the experimental group was 0.30%,which was lower than that in the control group (1.90%),and the difference was statistically significant (P＜0.05).The total satisfaction rate of the experimental group was 99.70%,which was higher than that of the control group(97.50%),and the difference was statistically significant (P＜0.05).The disease knowledge mastery scores of both groups were higher after intervention than those before intervention,and the differences were statistically significant (P＜0.05).After intervention,the disease knowledge mastery score of the experimental group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Medical examiner in Mudanjiang City receive effective health education,which can prevent and control the occurrence of syphilis and AIDS better,and reduce the incidence of infectious diseases.
		2021 Vol. 28 (9): 147-149转153 [Abstract] ( 42 ) HTML (34 KB) PDF (0 KB) ( 6 )

	150	Application of online teaching in general surgery teaching during normal prevention and control period of COVID-19
		WANG Zhen; CHEN Jun-qiang▲
		With the progress of information technology,online teaching has gradually entered the stage of medical education.As a result of the COVID-19′S outbreak this year,the Ministry of Education has issued a call to "suspended class,ongoing learning".This research′s unit also responded positively and practiced online teaching in the teaching of general surgery.However,some problems were encountered and some experience were accumulated in the implementation and management of online teaching,such as urging teachers to innovate online teaching theory and to elaborately design teaching plans,and requiring schools to improve online teaching facilities and to construct a new online teaching evaluation system.At present,the COVID-19 epidemic has entered the stage of normal prevention and control,and online teaching has been constantly applied and promoted.This research shares the experience of the unit of this research in online teaching of general surgery,so as to promote the popularization and the effect of online teaching in general surgery.
		2021 Vol. 28 (9): 150-153 [Abstract] ( 47 ) HTML (34 KB) PDF (0 KB) ( 6 )

	154	Application of case teaching method in pharmacy undergraduate course of Biopharmaceutics and Pharmacokinetics
		GAO Xiu-rong; WU Min; LIAO Hong-li ;XU Xiao-hong▲
		At present,the disadvantages of the teacher-centered traditional teaching mode are increasingly prominent,so the reform of the traditional teaching mode is imperative.Case teaching method can overcome the disadvantages of traditional teaching mode and has significant advantages in cultivating students′ comprehensive quality.This research attempts for the first time to carry out case teaching in the chapter "Non-oral Drug Absorption" of Biopharmaceutics and Pharmacokinetics course of pharmacy undergraduate course,including case selection,writing of teaching cases,implementation of case teaching and effect evaluation.The results show that compared with the traditional teaching mode,the students have higher recognition degree for case teaching.For pharmacy undergraduates,"traditional teaching is the main teaching mode,supplemented by case teaching" is the best teaching mode,which is worth popularizing.
		2021 Vol. 28 (9): 154-158 [Abstract] ( 41 ) HTML (40 KB) PDF (0 KB) ( 5 )

	159	The role of virtual simulation combined with clinical case-based teaching method in the promotion of learning interest of postgraduate in medical school
		ZHANG Yue-shun; LU Xiang-yu;ZHOU Xuan; LIU Zai-ying;HAN Ji-cheng;NAN Xi-hao▲
		Objective To explore the virtual simulation combined with clinical case-based teaching method (CBL) in the promotion of learning interest of postgraduates in medical school.Methods A total of 44 postgraduates in Mudanjiang Medical College from April 2017 to April 2019 were selected as research objects,and divided into the observation group and the control group according to random drawing lots method,with 22 postgraduates in each group.The observation group used virtual simulation combined with CBL teaching method,while the control group used the traditional teaching mode.The scores of theoretical knowledge examination,the scores of objective structured clinical examination (OSCE),practical ability,students′ teaching satisfaction and learning interest scores were compared between the two groups.Results The scores of theoretical knowledge,the scores of OSCE and practical ability in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).The teaching satisfaction and learning interest scores in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Combining virtual simulation and CBL teaching method to train medical students is helpful to improve their interest in learning,and to improve their theoretical knowledge test scores and practical ability.And the teaching model can improve the teaching satisfaction of medical students,clinical application value is high.
		2021 Vol. 28 (9): 159-161 [Abstract] ( 43 ) HTML (31 KB) PDF (0 KB) ( 5 )

	162	Promoting the construction of harmonious doctor-patient relationship by medical students′ volunteer service as the carrier
		WANG An-yun;FAN Jing-yi▲
		Nowadays,the situation,doctor-patient relationship is severe.So,it is high time to construct harmonious doctor-patient relationship.As the reserve army of future doctors,medical students can contribute to the construction of harmonious doctor-patient relationship through voluntary service.This paper introduces the present situation of medical students′ voluntary service,and analyzes the mechanism of medical students′ voluntary service to promote the construction of harmonious doctor-patient relationship from the two angles of “educating people” and “helping others”.Combined with a specific project,the article holds that medical students′ volunteer service should be optimized in China,and develop the new model of voluntary service for medical students in the four-in-one of “schoo-hospital-government-society”,promote the development of innovative trends such as “medicine+” and “Internet+voluntary service”,call for the establishment and improvement of voluntary service system and the strengthening of policy support for voluntary service in colleges and universities.
		2021 Vol. 28 (9): 162-164转168 [Abstract] ( 45 ) HTML (35 KB) PDF (0 KB) ( 7 )

	165	Influence of strengthening health education on drug treatment compliance of patients with pulmonary tuberculosis
		YI Xiao-fen
		Objective To explore the influence of strengthening health education on drug treatment compliance of patients with pulmonary tuberculosis.Methods A total of 60 cases of pulmonary tuberculosis patients in General Hospital of Pingxiang Mining Group Co.,Ltd from January 2017 to November 2019 were selected as the research objects,and they were divided into the control group(30 cases)and the observation group(30 cases)according to the random number table method.The control group was given routine nursing,and the observation group was given intensive health education.The psychological status,quality of life,tuberculosis related knowledge and compliance were compared between the two groups.Results After the intervention,the scores of Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)in the observation group were lower than those in the control group,the scores of short form health questionnaire 36(SF-36) and the mastery of tuberculosis related knowledge of the observation group were higher than those of the control group,the differences were statistically significant (P＜0.05).The total compliance of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Strengthening health education has positive significance for patients with pulmonary tuberculosis,which can improve patients′anxiety,depression and other negative emotions,and SF-36 score is higher,patients have more knowledge about pulmonary tuberculosis,drug treatment compliance is higher,and application value is higher.
		2021 Vol. 28 (9): 165-168 [Abstract] ( 43 ) HTML (30 KB) PDF (0 KB) ( 7 )

	169	Three case reports of acute ischemic stroke after percutaneous coronary intervention in the elderly
		HUANG Xing-lu; SHI Xiang▲
		Acute ischemic stroke is a rare but serious complication of percutaneous coronary intervention (PCI).Particularly,there are poor prognosis and high risk of death in elderly patients,which seriously affects the quality of life.In recently years,there were 3 cases of acute ischemic stroke after PCI in Department of Geriatrics,Xiangxi Autonomous Prefecture People′s Hospital.All the 3 elderly patients had a history of hypertension and diabetes,they occured different degrees of stroke symptoms after PCI.The final clinical diagnosis was acute ischemic stroke,with poor prognosis.Clinically,PCI should be more cautious for elderly patients with multiple risk factors at the same time,especially those with no intervention for risk factors and previous history of ischemic stroke.The surgeon should try to operate in a standard and gentle manner to minimize the risk and fully assess the risk of ischemic stroke before surgery.
		2021 Vol. 28 (9): 169-171 [Abstract] ( 46 ) HTML (28 KB) PDF (0 KB) ( 7 )

	172	A case and literature review of cerebral hemorrhage with delayed rupture of spleen
		SHENG Yang ;YANG Lu ;PENG Tao; TAO Gan ;XIE Liang
		Delayed rupture of the spleen referred to all kind of spleen rupture being injuried,which presented as injured splenic subcapular hematoma,or slow bleeding with little gap under the spleen capsule,or not bleeding temporarily because of blood coagulation.The phenomenon of intraperitoneal hemorrhage only appears under certain inducement.The spleen in physiological state is soft and brittle,which is prone to rupture and bleeding due to critical impact.The spleen in pathological state is more likely to rupture due to enlargement and brittleness.Due to its untypical clinical manifestations,hidden symptoms,the diagnosis of delayed rupture of spleen was difficult or even turned out wrong,directly causing the treatment to be delayed.This paper analyzed one case of cerebral hemorrhage with delayed rupture of spleen being understood the etiology,pathogenesis and current diagnosis.So as to better serve the clinical.
		2021 Vol. 28 (9): 172-174 [Abstract] ( 38 ) HTML (28 KB) PDF (0 KB) ( 7 )

	175	A case report and literature review of systemic lupus erythematosus with macrophage activation syndrome in children
		ZHANG Man; ZHANG Tian-tian;GE Chang-chang;MA Ying-ying;WANG Bing-zeng
		Macrophage activation syndrome(MAS)is a serious and potentially life-threatening complication of rheumatic disease,which is classified into the category of secondary hemophagocytic lymphohistiocytosis (HLH).MAS is often secondary to systemic juvenile idiopathic,however systemic lupus erythematosus (SLE) complicated by MAS is rare in children.Moreover,formal HLH-2004 criteria are frequently insensitive for MAS diagnosis,thus disease-specific MAS criteria have been published.In this paper,the clinical recognition,diagnostic guidelines and treatment of children with SLE complicated by MAS were reviewed by a case report and the literature review.
		2021 Vol. 28 (9): 175-177转212 [Abstract] ( 41 ) HTML (30 KB) PDF (0 KB) ( 5 )

	178	Bibliometric analysis of Peplau′s relationship theory in domestic nursing field
		ZHOU Hong-juan;WANG Xiao-bin; HU Jing-wen; WENG Mei-hua;CHEN Jin-xiu
		Objective To definite the research status and foucus of Peplau′s relationship theory in domestic nursing field.Methods The CNKI,Wanfang,VIP and CBM,and published articles related to Peplau′s interpersonal relationship theory and nursing subject words by May 2020 were retrieved.Note Express software and EXCEL were used to conduct econometric analysis on the annual publication volume and distribution area.Results A total of 96 literature was included,which included some problems such as an uneven number of literature publishing regions,fewer core journals and fund support,etc.Clinical nursing practice and nursing education were mainly applied in the field of the theory.Conclusion There are few studies on Peplau′s relationship theory in China.Hence,we need to expand the breadth and depth of research on Peplau′s relationship theory and improve the problems of the lack funding for scientific research and the limitations of research methods and contents.
		2021 Vol. 28 (9): 178-181 [Abstract] ( 39 ) HTML (37 KB) PDF (0 KB) ( 8 )

	182	Investigation and research on the needs of continuous nursing service for patients with ischemic stroke in Yangjiang City
		ZHANG Xiao-min;ZHANG Zhi-mei;CAI Yan-ting; CHEN Xing-jiao
		Objective To understand the needs of patients with ischemic stroke in Yangjiang urban area for continuing nursing services.Methods A total of 166 hospitalized patients with ischemic stroke in the Yangjiang People′s Hospital in Guangdong Province from June 2017 to November 2018 were selected as the research subjects.Patient for continuous nursing service demand scale and Barthel index score were used to evaluate patient′s needs and the ability of daily living (ADL),respectively.The correlation between the needs for continuous nursing service in ischemic stroke patients and the ability of ADL were analyzed.Results ①Continuous nursing needs of patients with ischemic stroke showed that the highest demand rate of patients for self-care services was 96.39%,and the demand score was (9.26±1.27) points.The lowest demand rate of health education and nursing services was 69.28%,and the demand score was (11.43±1.90)points.②With regards to the Barthel index score,the ADL scores at 1,3,and 6 months after discharge were higher than those at discharge,and the differences were statistically significant (P＜0.05).③Correlation showed that the patient′s demand for continuous nursing services at discharge had no correlation with the ability of ADL (r=-0.154,P＞0.05).④The patient′s demand for continuous nursing services at 1,3,and 6 months after discharge were positively correlated with the ability of ADL (r=0.236,0.167,0.221;P＜0.05).Conclusion Patients with ischemic stroke in the urban area of Yangjiang City generally have a higher demand for continuous nursing service after discharge.Practice has proved that continuous nursing service can significantly improve patients′ self-care ability and ADL,and promote patients′ recovery as soon as possible.
		2021 Vol. 28 (9): 182-184 [Abstract] ( 44 ) HTML (32 KB) PDF (0 KB) ( 7 )

	185	Influence of Mandala painting training on the rehabilitation of patients with postpartum depression
		LI Yang; SU Jian-ning;LAI Li-ping; LIU Yan
		Objective to explore the rehabilitation effect of Mandala drawing training on postpartum depression (PPD)patients.Methods A total of 80 PPD patients admitted to Ganzhou Third People′s Hospital,Jiangxi Province from June 2019 to June 2020 were selected,the patients were divided into the study group and the control group by random number table method,40 cases in each group.Two groups of patients were given routine treatment,the control group was given routine nursing,the study group was given training of drawing Mandala on the basis of the control group.Mental state,sense of happiness and nursing satisfaction of the two groups before and after intervention were compared.Results The scores of the self-rating anxiety scale (SAS) and Hamilton depression scale (HAMD) of the study group were lower than those of the control group (P＜0.05);the study group was happy at 4 and 8 weeks after the intervention the GWB score was higher than that of the control group (P＜0.05);the nursing total satisfaction of the study group was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion The application of Mandala painting in the treatment of PPD is effective.It can effectively improve the depression and anxiety of patients,improve happiness and nursing satisfaction.It is worthy of clinical application.
		2021 Vol. 28 (9): 185-187 [Abstract] ( 36 ) HTML (32 KB) PDF (0 KB) ( 6 )

	188	Application effect of continuous nursing mode after total hip replacement
		CHEN Min ;TIAN Shao-juan; WANG Dong-mei
		Objective To explore the application effect of continuous nursing model after total hip replacement (THR).Methods A total of 96 patients undergoing THR in the Second Affiliated Hospital of Nanchang University from January to August 2019 were selected.They were divided the control group (48 cases) and the study group (48 cases) by random touch ball method.The control group implemented routine discharge guidance,and the study group implemented continuous nursing mode.The changes of Harris score and Barthel index were compared between the two groups before operation and 1,3,and 6 months after operation,and the total incidence of complications and nursing satisfaction were compared.Results At 1,3,and 6 months after surgery,the Harris score and Barthel index of the study group were higher than those of the control group,the total complication rate of the study group was 4.17%,which was lower than that of the control group of 18.75%,the differences were statistically significant (P＜0.05).The nursing satisfaction score of the study group was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion The implementation of continuation nursing mode for patients undergoing THR can promote the recovery of joint function and activities of daily living,reduce the incidence of complications,and improve nursing satisfaction.
		2021 Vol. 28 (9): 188-190 [Abstract] ( 45 ) HTML (31 KB) PDF (0 KB) ( 9 )

	191	Effect of objective structured clinical examination mode in the standardized training of nurses
		JIANG Luo-yun; PENG Wei; WU Qin
		Objective To analyze the effect of the objective structured clinical examination (OSCE) assessment model in the standardized training of nurses.Methods A total of 100 standardized training nurses (referred to as nurses in regular training) admitted to the First Affiliated Hospital of Gannan Medical University from January to December 2018 were selected as the research objects.According to the lottery method,they were divided into observation group (50 cases) and control group (50 cases).The observation group was assessed by OSCE,and the control group was assessed by routine.The two groups′ professional ability scores and assessment method satisfaction were compared.Results The professional ability scores of the observation group were higher than those of the control group,and the differences were statistically significant (P＜0.05).The satisfaction degree of the observation group were higher than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion OSCE assessment mode can improve the professional ability of nurses,and has high satisfaction with the assessment method,which is conducive to the clinical nursing work in the future.
		2021 Vol. 28 (9): 191-193 [Abstract] ( 53 ) HTML (31 KB) PDF (0 KB) ( 6 )

	194	Application of fast track surgery concept in nursing care of retroperitoneal laparoscopic adrenalectomy
		ZHOU Bo
		Objective To explore the application of fast track surgery (FTS) concept in nursing care of retroperitoneal laparoscopic adrenalectomy.Methods A total of 60 patients with retroperitoneal laparoscopic adrenalectomy in Fuzhou First People′s Hospital,Jiangxi Province from May 2018 to March 2020 were selected and divided into the control group and the observation group according to random number table method,30 cases in each group.The control group was given conventional nursing mode,while the observation group was given FTS concept nursing.The operation time，postoperative blood loss,intraoperative body temperature and postoperative hypothermia,incidence of shivering,visual analogue scale (VAS) score and nursing satisfaction were compared between the two groups.Results The total satisfaction of the observation group was 96.67%,higher than 73.33% of the control group,the difference was statistically significant (P＜0.05);the incidence of postoperative hypothermia and shivering in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The operation time of the observation group was shorter than that of the control group,the postoperative bleeding volume was less than that of the control group,the VAS score was lower than that of the control group,the differences were statistically significant (P＜0.05).However,there was no significant difference in intraoperative body temperature between the two groups (P＞0.05).Conclusion The application of FTS in the treatment of patients with retroperitoneal laparoscopic adrenalectomy can effectively improve the patient′s condition,reduce the incidence of postoperative hypothermia and chills,shorten the operation time,relieve postoperative pain,and improve nursing satisfaction,which is worthy of promotion.
		2021 Vol. 28 (9): 194-196 [Abstract] ( 45 ) HTML (30 KB) PDF (0 KB) ( 8 )

	197	Application of ultra-early rehabilitation nursing in patients with brain stem injury
		LIU Xiao-fen
		Objective To explore the application of ultra-early rehabilitation nursing in patients with brain stem injury.Methods The clinical data of 71 patients with brainstem injury in Shangrao People′s Hospital in Jiangxi Province from March 2017 to December 2019 were retrospectively analyzed.According to different nursing methods,patients were divided routine the control group (n=35) and the observation group (n=36).The control group was given routine nursing,the observation group was given routine nursing+ultra-early rehabilitation nursing.Both groups were intervened for 4 weeks.The limb motor function,nursing satisfaction and complications of the two groups were compared.Results Before intervention,the scores of Fugl-Meyer exercise scale were compared between the two groups,the difference was not statistically significant (P＞0.05).After intervention,the Fugl-Meyer exercise scale score of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).The nursing total satisfaction of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Rehabilitation nursing intervention can reduce the occurrence of complications in patients with brain stem injury,improve the limb motor function and nursing satisfaction of patients.
		2021 Vol. 28 (9): 197-199 [Abstract] ( 50 ) HTML (31 KB) PDF (0 KB) ( 8 )

	200	Application effect of quantitative assessment guiding double point nursing in adolescents with first-episode schizophrenia
		YE Xu-xia
		Objective To observe the application effect of quantitative assessment guiding double point nursing in adolescents with first-episode schizophrenia.Methods A total of 80 adolescents with first-episode schizophrenia admitted to Shangrao Third People′s Hospital in Jiangxi Province from January 2017 to June 2019 were selected as the research objects and divided into the control group and the test group according to the random number table method,40 cases in each group.The control group was treated with routine nursing,while the test group was treated with quantitative assessment guiding double point nursing,and the observed indexes after intervention were compared between the two groups.Results The treatment total compliance of adolescents with schizophrenia after intervention in the test group was higher than that in the control group,and the scores of psychotic symptoms and quality of life in the test group were lower than those in the control group,the differences were statistically significant (P＜0.05).Conclusion The intervention of quantitative assessement guiding double point nursing in adolescents with first-episode of schizophrenia can significantly improve the treatment compliance,and promote the improvement of psychotic symptoms and quality of life.
		2021 Vol. 28 (9): 200-202 [Abstract] ( 45 ) HTML (32 KB) PDF (0 KB) ( 6 )

	203	Application of traditional Chinese medicine treatment and comprehensive nursing in patients with liver injury after AIDS antiviral treatment
		LUO Yin-di ;LI Wan-xia
		Objective To explore the application of traditional Chinese medicine treatment and comprehensive nursing in patients with liver injury after acquired immune deficiency syndrome (AIDS) antiviral therapy.Methods A total of 150 AIDS patients admitted to Dongguan People′s Hospital,Guangdong Province from January to December 2019 were selected as the research objects,and were divided into the control group and the observation group according to the random number table method,75 cases in each group.The control group was treated with Western medicine+comprehensive nursing,and the observation group was treated with traditional Chinese medicine+comprehensive nursing.The total effective rate,liver function indexes and nursing satisfaction of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).After the intervention,the levels of aspartate aminotransferase,alanine aminotransferase,serum total bilirubin,and direct bilirubin in the two groups were lower than those before the intervention,and the differences were statistically significant (P＜0.05);the levels of aspartate aminotransferase,alanine aminotransferase,serum total bilirubin,and direct bilirubin in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The total satisfaction of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion The combination of traditional Chinese medicine and comprehensive nursing care can improve the liver function and improve the overall satisfaction of the patients after anti-virus treatment.It is worth popularizing and applying.
		2021 Vol. 28 (9): 203-205 [Abstract] ( 38 ) HTML (31 KB) PDF (0 KB) ( 8 )

	206	Application and nursing of axillary vein indwelling catheter in long-term transfusion of newborn
		ZHANG Shuai-hong; CAO Yu-ping ;CAO Jun
		Objective To explore the application and nursing of axillary vein puncture in long-term transfusion of newborns.Methods A total of 100 newborns required more than one week of infusion in the neonatal intensive care unit of the Second People′s Hospital of Jingdezhen from January 2019 to August 2020 were selected as the research objects,and they were divided into the control group and the experimental group according to random number table method,with 50 cases in each group.The control group was given scalp and limb distal infusion,and the experimental group was given axillary vein indwelling needle infusion.The average retention time of indwelling tube,the total incidence of complications,the success rate of one-time puncture and the satisfaction of doctors were compared between the two groups.Results The indwelling time of the experimental group was longer than that of the control group,and the difference was statistically significant (P＜0.05).The total incidence of complications in the experimental group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The success rate of onetime puncture in the experimental group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The doctor′s satisfaction after nursing in the experimental group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Axillary vein indwelling needle has long retention time and less complications in neonatal infusion.The success rate of one puncture is higher than that of doctor′s nursing satisfaction.
		2021 Vol. 28 (9): 206-208 [Abstract] ( 46 ) HTML (31 KB) PDF (0 KB) ( 8 )

	209	Application effect of comfort nursing in the diagnosis and treatment of oral prosthodontics in elderly patients
		TIAN Li
		Objective To explore the application effect of comfortable nursing in the treatment of oral cavity repair in elderly patients.Methods A total of 102 patients with oral diseases admitted to Dalian Stomatological Hospital,Liaoning province from June 2018 to May 2019 were selected as the research objects.They were divided into the control group(51 cases) and the observation group (51 cases) according to the lottery method.The control group received routine nursing and the observation group received comfort nursing.The diagnosis and treatment,nursing comfort and self-efficacy of the two groups were compared.Results After nursing,the observation group′s oral cavity repair knowledge mastery degree score was higher than that of the control group,the treatment time was shorter than that of the control group,the differences were statistically significant (P＜0.05).The incidence of adverse events during diagnosis and treatment was lower than that of the control group,the comfort levels such as physiology,mentality and environment of the observation group was higher than that of the control group,the self-efficacy of the observation group was stronger than that of the control group,the differences were statistically significant (P＜0.05).Conclusion The implementation of comfort nursing in the oral repair diagnosis and treatment of elderly patients can effectively improve the patients′ grasp of oral repair knowledge,shorten the treatment time,reduce the incidence of adverse events during the diagnosis and treatment,improve their nursing comfort,strengthen the sense of self-efficacy.
		2021 Vol. 28 (9): 209-212 [Abstract] ( 46 ) HTML (32 KB) PDF (0 KB) ( 7 )

	213	Effect of external application of fresh potato chips on iron sucrose-induced phlebitis
		LIU Fang ;WANG Jian▲
		Objective To observe the effect of using externally applied fresh potato chips to treat iron sucrose-induced phlebitis.Methods Ninety-nine female patients with phlebitis caused by intravenous infusion of iron sucrose due to anemia who were hospitalized in the Second Affiliated Hospital of Dalian Medical University from January 2017 to October 2019 were selected as the research subjects.They were numbered according to the order of their admission.Fifty patients with odd numbers were considered as the observation group,49 patients with even numbers were categorized into the control group.Patients in the observation group were treated with external application of fresh potato chips;in the control group,they were treated with 25% Magnesium Sulfate (MgSO4) for wet compress.The therapeutic total effective rate of phlebitis and the nursing total satisfaction from patients were compared between the two groups.Results The therapeutic total effective rate in the observation group was higher than that of the control group,with statistical difference (P＜0.05).The nursing total satisfaction in the observation group was higher than that of the control group,with statistical difference (P＜0.05).Conclusion The effect of external application of fresh potato chips in the treatment of iron sucrose-induced phlebitis is higher than that of Magnesium Sulfate for wet compress alone.Meanwhile,the operation is simple,the patient is easy to accept,and the nursing satisfaction is improved.
		2021 Vol. 28 (9): 213-216 [Abstract] ( 42 ) HTML (35 KB) PDF (0 KB) ( 4 )

	217	Application effect of evidence-based nursing in patients with coronary heart disease and hypertension
		LIANG Hong-yan
		Objective To explore the application effect of evidence-based nursing on improving the quality of life of patients with coronary heart disease and hypertension.Methods A total of 86 patients with coronary heart disease and hypertension treated in Benxi Jinshan Hospital,Liaoning Province from December 2018 to December 2019 were selected as the research objects.The patients were divided into two groups with odd and even numbers,in which the odd number was the control group (43 cases),and the even number was the observation group (43 cases).The nursing effect of the two groups was compared.Results The quality of life scale (SF-36) score of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05）.The blood pressure indexes of diastolic blood pressure and systolic blood pressure in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05）.The nursing total satisfaction of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05）.Conclusion The implementation of evidence-based nursing in patients with coronary heart disease and hypertension has good effect,which can effectively improve the quality of life of patients.
		2021 Vol. 28 (9): 217-219 [Abstract] ( 49 ) HTML (30 KB) PDF (0 KB) ( 8 )

	220	Application of personalized comfort nursing in gynecological laparoscopic surgery patients
		WANG Xiao-na
		Objective To analyze the application effect of personalized comfort nursing in gynecological laparoscopic surgery patients.Methods A total of 110 gynecological laparoscopic surgery patients admitted to the Second People′s Hospital from June 2019 and January 2020 were selected as study subjects.According to the random number table method,the patients were divided into the reference group (55 cases) and the study group (55 cases).The reference group adopted conventional nursing,while the study group adopted individual comfort nursing,and the operation,comfort,mood and pain status of the two groups were compared.Results The Hamilton anxiety scale (HAMA),Hamilton depression scale (HAMD) and visual analogue scale (VAS) scores of the study group were lower than those of the reference group,Kolcaba′s general comfort questionnaire (GCQ) score was higher than that of the reference group,the differences were statistically significant (P＜0.05).The operation time and hospital stay of the research group were shorter than those of the reference group,and the intraoperative bleeding volume was less than that of the reference group,the differences were statistically significant (P＜0.05).Conclusion Taking individualized comfort nursing is of positive clinical value to improve the operation of patients undergoing gynecological laparoscopy,improve their comfort,relieve pain and mood.
		2021 Vol. 28 (9): 220-222转226 [Abstract] ( 55 ) HTML (30 KB) PDF (0 KB) ( 6 )

	223	Nursing application of developmental care in neonates with congenital esophageal atresia
		HE Jing
		Objective To explore the application effect of developmental care in the perioperative nursing of neonatal congenital esophageal atresia.Methods The clinical data of 102 newborns with congenital esophageal atresia admitted to Urumqi First People's Hospital from January 2016 to December 2019 were analyzed retrospectively.According to different nursing methods,they were divided into observation group (52 cases) and control group (50 cases),observation group perioperative nursing was adopted for developmental care,and the control group was given conventional perioperative nursing.The surgical indicators,temperature changes,postoperative recovery and the total incidence of postoperative complications were compared between the two groups.Results There was no statistically significant difference in the operation time between the two groups of children (P＞0.05);the intraoperative blood loss in the observation group was less than that of the control group,and the duration of stay and hospitalization in the neonatal intensive care unit (NICU) were shorter than those of the control group,the differences were statistically significant (P＜0.05);there was no statistically significant difference in body temperature between the two groups before surgery (P＞0.05);the body temperature of the observation group at 1,2 h and at the end of the operation were higher than those of the control group,the differences were statistically significant (P＜0.05);the postoperative wake-up time of the observation group was shorter than that of the control group,the increase in weight was greater than that of the control group,and the number of nutritional supplement days was shorter than that of the control group,the differences were statistically significant (P＜0.05);the total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The use of developmental care during the perioperative period in neonates with congenital esophageal atresia has a good effect.It can reduce intraoperative blood loss,shorten hospitalization,stabilize the body temperature of children,and reduce postoperative complications.It is worthy of promotion.
		2021 Vol. 28 (9): 223-226 [Abstract] ( 53 ) HTML (32 KB) PDF (0 KB) ( 6 )

	227	Influence of team resource management model nursing intervention on neurological function and language function of patients with acute cerebral infarction
		XU-Huimin ;SUN-Jin ;WEN-Jiao▲
		Objective To explore the influence of team resource management model nursing intervention on neurological function and language function of patients with acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction who were admitted to the First Affiliated Hospital of Dalian Medical University from February 2019 to March 2020 were selected as the research subjects.They were divided into an observer control group according to the random number table method,with 40 cases in each group.The observation group was given team resource management model nursing,while the control group was given routine nursing care.The clinical treatment efficiency indexes were compared between the two groups;the European stroke scores (ESS) before and after nursing intervention were compared between the two groups;the changes of language ability before and after nursing intervention in two groups were compared;the incidence of complications during the nursing intervention of thrombolytic therapy was compared between the two groups.Results The time of diagnosis and application of thrombolytic drug in the observation group were shorter than those in the control group,the differences were statistically significant (P＜0.05).After intervention,the ESS score in the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).The language ability score in observation group was higher than that of control group,the difference was statistically significant (P＜0.05).Dure that nursing intervention of thrombolytic therapy,the total incidence of complication in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion The implementation of team resource management mode nursing management for acute cerebral infarction can effectively shorten the effective treatment time and improve the prognosis of patients' neurological function,so it can improve language function and reduce complications.
		2021 Vol. 28 (9): 227-230 [Abstract] ( 46 ) HTML (34 KB) PDF (0 KB) ( 6 )

	231	Effect of high-quality nursing intervention in the prevention and treatment of cold patients
		ZHANG Hui-zhu
		Objective To explore the effect of high-quality nursing intervention in the prevention and treatment of colds.Methods A total of 70 patients with cold admitted to Dandong traditional Chinese Medicine Hospital from September 2018 to September 2019 were selected as the research objects and divided into the observation group and the control group according to random number table method,with 35 cases in each group.The observation group was given high quality nursing,and the control group was given routine nursing.The time of symptom disappearance,immune index and respiratory infection were compared between the two groups.Results The time of disappearance of cough,fever,fatigue and sore throat in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in CD4+,CD8+,CD4+/CD8+ levels between the two groups before intervention (P＞0.05).After the intervention,the CD4+,CD8+,CD4+/CD8+ levels of the two groups were higher than those before intervention,and the CD4+ and CD8+ levels of the observation group was higher than that of the control group,the differences were statistically significant (P＜0.05).After intervention,the first respiratory tract infection time in the observation group was longer than that in the control group,and the total number of recurrence of respiratory tract infection within 3 months was less than that in the control group,the differences were statistically significant (P＜0.05).Conclusion The application of high-quality nursing intervention in the prevention and treatment of colds could improve the immunity of patients,reduce the number of relapses,and speed up the recovery of symptoms.It is worthy of promotion.
		2021 Vol. 28 (9): 231-233 [Abstract] ( 46 ) HTML (32 KB) PDF (0 KB) ( 7 )

	234	Application effect of Newman nursing in patients with glomerulonephritis
	Application effect of Newman nursing in patients with glomerulonephritis [J]. 中国当代医药, 2021,28(9): 234-237')" href="#">	LIU Xin
		Objective To explore the effect and value of Newman nursing care for patients with glomerulonephritis.Methods A total of 86 patients with glomerulonephritis who were admitted to Liaohe Oilfield Gem Flower Hospital from June 2017 to July 2019 were selected as the research subjects.They were divided into control group (43 cases) and observation group (43 cases) according to the random number table method.The control group received routine nursing,and the observation group received routine nursing combined with Newman nursing.The mental status,disease control effect,nursing satisfaction and quality of life were compared between the two groups.Results After intervention,the scores of Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) scores in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The total effective rate of disease control and nursing satisfaction in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).In the observation group,the scores of physical,psychological,social function and physical life status of the general assessment questionnaire of quality of life (GQOLI-74) after intervention were higher than those of the control group,the differences were statistically significant (P＜0.05).Conclusion To strengthen Newman nursing intervention can improve the mental state of patients with Glomerulonephritis,improve the effect of disease control,and improve the quality of life.
		2021 Vol. 28 (9): 234-237 [Abstract] ( 51 ) HTML (34 KB) PDF (0 KB) ( 7 )

	238	Effect of continuous nursing on postoperative rehabilitation,self-care ability and quality of life of patients with prostatic hyperplasia
		YANG Chun-ling
		Objective To explore the effect of continuous nursing on postoperative rehabilitation，self-care ability and quality of life of patients with prostatic hyperplasia (BPH).Methods A total of 80 patients with BPH admitted to Liaoyang Central Hospital,Liaoning Province from March 2017 to December 2019 were selected as the research objects,and were divided into the observation group and the control group according to the random number table method,40 cases in each group.The control group was given routine nursing,while the observation group was given continuous nursing.The postoperative recovery conditions of the two groups were compared,and the scores of the self-care ability scale (ESCA) and the WHOQO-BREF in the two groups were observed before and after intervention.Results After the intervention,postoperative anal exhaust time,first time out of bed and hospital stay time in the observation group were shorter than those in the control group,with statistically significant differences (P＜0.05).ESCA scores and WHOQOBREF scores in both groups after intervention were higher than those before intervention,and ESCA scores and WHOQO-BREF scores in the observation group were higher than those in the control group,with statistically significant differences (P＜0.05).Conclusion The application of continuous nursing in patients with BPH is helpful in promoting postoperative physical rehabilitation,and improving self-care ability and quality of life.
		2021 Vol. 28 (9): 238-240 [Abstract] ( 42 ) HTML (29 KB) PDF (0 KB) ( 7 )

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