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| A case report and literature review of systemic lupus erythematosus with macrophage activation syndrome in children |
| ZHANG Man1 ZHANG Tian-tian1 GE Chang-chang1 MA Ying-ying2 WANG Bing-zeng1▲ |
1.Department of Pediatrics,First Affiliated Hospital of Henan University,Henan Province,Kaifeng 475000,China;
2.Department of Pediatrics,First Affiliated Hospital of Zhengzhou University,Henan Province,Zhengzhou 450000,China |
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Abstract Macrophage activation syndrome(MAS)is a serious and potentially life-threatening complication of rheumatic disease,which is classified into the category of secondary hemophagocytic lymphohistiocytosis (HLH).MAS is often secondary to systemic juvenile idiopathic,however systemic lupus erythematosus (SLE) complicated by MAS is rare in children.Moreover,formal HLH-2004 criteria are frequently insensitive for MAS diagnosis,thus disease-specific MAS criteria have been published.In this paper,the clinical recognition,diagnostic guidelines and treatment of children with SLE complicated by MAS were reviewed by a case report and the literature review.
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