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| Study on the action mechanism of Gleditsiae Spina in the treatment of breast cancer based on network pharmacology |
| QUAN Qi CHEN Ping HUANG Yuan-yuan ZHANG Bei▲ |
| Department of Traditional Chinese Medicine,Sun Yat-sen University Cancer Center,Guangdong Province,Guangzhou 510060,China |
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Abstract Objective To explore the key targets and signal pathways of Gleditsiae Spina in the treatment of breast cancer and provide a basis and some evidence for further research.Methods Chemical components and targets of Gleditsiae Spina and the targets related to breast cancer were collected by searching databases.Common targets were mapped out by using R language.A protein interaction network (PPI) was constructed to extract key targets.GO and KEGG enrichment analysis were performed by using R language."Component-target" and "target-pathway" network was built to extract key targets and pathways.Results Eleven active ingredients and 174 targets of Gleditsiae Spina,1132 targets related to breast cancer and 88 common targets were obtained after screening.Total 104 GO entries and 144 KEGG signal paths were yielded by enrichment analysis.Three key targets in the PPI network were enriched in key pathways.The targets were MAPK1,AKT1,RELA and the pathways involved were cancer,cell apoptosis,TNF signaling pathway,infection,IL-17 signaling pathway and endocrine resistance.Conclusion Gleditsiae Spina may play an anti-breast cancer effect by targeting MAPK1,AKT1 and RELA in related pathways.
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