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2019 Vol. 26, No. 8
Published: 2019-03-18
 
 
9 Effect study of ABCG2 in gefitinib resistance in non-small cell lung cancer
WANG Lei; WANG Ming-ji; HUANG Lei; DAI Lu-lu; LI Yan-jun ; ZHENG Yu-jun
Objective To investigate the effect of ATP-binding cassette superfamily G member 2 (ABCG2)in gefitinib resistance in non-small cell lung cancer(NSCLC),and to provide a basis for gefitinib-resistance of NSCLC.Methods The human lung adenocarcinoma gefitinib-sensitive cell line A549 and gefitinib-resistant human lung adenocarcinoma cell line A549/GR were cultured.A549/GR cells were tested for drug resistance by MTT assay.Western blot was used to detect the expression of ABCG2 and p-AKT proteins in A549/GR and A549 cells.Phosphatidylinositol 3 kinase/serine-threonine kinase(PI3K/AKT)pathway activator insulin-like growth factor-1(IGF-1)and LY294002 acted as inhibitor were added,respectively.The expression of p-AKT and ABCG2 proteins on the above two kinds of cells were analyzed.The efflux of ABCG2 in A549 and A549/GR cell lines was determined by flow cytometry.The serum of nonsmall cell lung cancer(NSCLC)patients and healthy people treated in our hospital from April 2015 to April 2017 were collected,they were divided into NSCLC non-drug resistant group (20 cases),NSCLC Gefitinib resistance group(20 cases)and healthy group (20 cases).The expression of ABCG2 in the three groups were detected by ELISA method.Results With the increase of dose,the inhibitory effect of gefitinib on A549 cells and A549/GR cells were enhanced(P＜0.05).The resistance index of A549/GR was 13.4.Western Blot detected for drug-resistance proteins showed that the levels of ABCG2 and p-AKT in drug-resistant A549/GR cell were both higher than those in the parental cell A549.The expression of p-AKT and ABCG2 proteins were increased in A549 cells treated with IGF-1 (P＜0.05),while treated by LY294002,the levels of p-AKT and ABCG2 were both down-regulated in A549/GR cells(P＜0.05).After IGF-1 acting on A549 cells,the efflux was enhanced in A549 cells compared with that without activation(P＜0.05).After A549/GR cells being treated with LY294002,the efflux effect was decreased in A549/GR cells compared with that without activator(P＜0.05).The expression of ABCG2 in healthy participants was obviously lower than that in patients of NSCLC non-drug resistant group(P＜0.05).The expression of ABCG2 in patients of NSCLC Gefitinib resistance group was higher than that in NSCLC non-drug resistant group and healthy participants(P＜0.05).Conclusion ABCG2 plays a key role in gefitinib-resistant NSCLC.Reversal of ABCG2-mediated NSCLC-targeted drug resistance is mainly through regulation of the PI3K/AKT signaling pathway.
2019 Vol. 26 (8): 9-13 [Abstract] ( 89 ) HTML (42 KB)  PDF  (0 KB)  ( 12 )
14 Value of brain function monitoring combined blood lactate in predicting abnormal neurodevelopmental behavior in neonates with asphyxia
TAN Li-fen; GUO Xiao-fang; YUAN Shu-yan
Objective To explore the the value of brain function monitoring combined blood lactate in predicting abnormal neurodevelopmental behavior in neonates with asphyxia.Methods A total of 69 cases of asphyxia neonates(Apgar score≤7 points)received from January 2017 to June 2018 treated in our hospital were included in this study.The lactic acid (LA)level was measured in peripheral arterial blood 1 hour after birth.Neonatal amplitude integrated electroencephalogram(aEEG)was monitored at the 6thhour and the 3rdday after birth,and the neurodevelopmental behavior at the 3rdmonth was assessed by Geiser′s Developmental Scale (Gesell).The neurodevelopmental behaviors under different aEEG indexings at 6thhour and the 3rdday were compared.The neurodevelopmental behaviors under different LA indexes were analyzed.The efficacy of aEEG,LA and aEEG combined with LA in the diagnosis of neurodevelopmental abnormalities were evaluated.Results The neurodevelopmental behavior in neonates with asphyxia of LA＜2.66 mmol/L group was significantly better than that of LA＞4.50 mmol/L group,the difference was statistically significant(P＜0.05).The neurodevelopmental behavior of neonates with asphyxia of the aEEG normal group and mild abnormal group were significantly better than that of severe group,the differences were statistically significant(P＜0.05)；the neurodevelopmental behavior of neonates with asphyxia of the aEEG normal group was significantly better than that of the mild abnormal group and severe abnormal group,the differences were statistically significant(P＜0.05).The highest sensitivity of aEEG+LA predicts at the 6thhour after birth was 95.35%of neurodevelopmental behavior in neonates with asphyxia.The aEEG+LA predicts at the 3rdday the neonatal developmental abnormality of neonatal developmental disorder was the highest,which was 0.6538.Conclusion aEEG and LA can respond to early neurodevelopmental behavior abnormalities in neonates with asphyxia.The 6thhour after birth,AEEG+LA predicts the highest neurodevelopmental abnormality in neonates with asphyxia.The predicted efficacy of the 3rdday aEEG+LA is the best.
2019 Vol. 26 (8): 14-17 [Abstract] ( 78 ) HTML (38 KB)  PDF  (0 KB)  ( 11 )
18 Expression and clinical significance of Th17/Treg and related cytokines in peripheral blood of patients with bronchial asthma
SHU Jiao-jie; LIU Si-bo; LIU Guo-liang; ZHOU Heng-jie; GE Dong
Objective To investigate the expression and clinical significance of helper T cell 17 (Th17)/regulatory T cell(Treg)and related cytokines in peripheral blood of patients with bronchial asthma.Methods A total of 84 patients with acute bronchial asthma admitted in our hospital from October 2016 to October 2017 were enrolled as asthma group.Another 50 healthy people were selected as control group at the same time.The levels of Th17 cells and Treg cells were detected by flow cytometry,the expression levels of serum interleukin-17(IL-17),interleukin-10(IL-10)and transforming growth factor-β1(TGF-β1)were detected by enzyme-linked immunosorbent assay(ELISA),and pulmonary function index was also measured.The correlations between levels of Th17 cells,Treg cells,IL-17,IL-10,TGF-β1and pulmonary function index in patients with bronchial asthma were analyzed.Results The levels of Th17 cells,Th17/Treg and IL-17 in asthma group in acute stage were statistically higher than those in remission stage and control group,and the above indexes in the remission stage were higher than those in the control group (P＜0.05).The levels of IL-10,TGF-β1,Treg and the indexes pulmonary function in asthma group in acute stage were statistically lower than those in control group and remission stage,and those in the asthma group in remission stage were lower than those in the control group (P＜0.05).The levels of Th17 cells and IL-17 were negatively correlated with pulmonary function in asthma group in acute stage,and Treg cells,IL-10 and TGF-β1 were positively correlated with lung function indexes(P＜0.05).Conclusion There is a balance disorder of Th17/Treg in peripheral blood in patients with bronchial asthma,and the secretion of related cytokines is abnormal.The change of Th17/Treg in peripheral blood can reflect the level of inflammation in patients with bronchial asthma,which is helpful to further study the mechanism of asthma and provide a new strategy for clinical diagnosis and treatment.
2019 Vol. 26 (8): 18-21 [Abstract] ( 90 ) HTML (45 KB)  PDF  (0 KB)  ( 13 )
22 Screening of siRNA for PTEN gene silencing in mouse primary hepatocytes
ZHOU Long;WANG Li-lin;HU Xu-huai
Objective To screen siRNA for PTEN gene silencing in mouse primary hepatocytes.Methods Primary mouse hepatocytes were isolated by two-step collagenase perfusion,the hepatocytes were plated in collagen-coated 25 cm2 flasks at a density of 1×106cells/flask.The hepatocytes were divided into five groups on average：control group(C group),negative control group(NC group),siR-996 group,siR-1381 group,siR-1519 group.The siRNA of each group were transferred into mouse primary hepatocytes by HiPerFect transfection reagent,extracted RNA and protein after 24 h.The expression of PTEN mRNA was detected by Real-time PCR and the content of PTEN protein was detected by Western blot.Results The PTEN protein content of the siR-996 group,siR-1381 group and siR-1519 group were lower than that of the NC group,the differences were statistically significant(P＜0.01).The PTEN mRNA level of the siR-996 group,siR-1381 group and siR-1519 group were lower than that of the NC group,the differences were statistically significant(P＜0.01).The PTEN protein content and PTEN mRNA level of siR-996 group were the lowest,the silencing efficiency of PTEN protein content and PTEN mRNA level was higher than that of siR-1381 group and siR-1519 group.Conclusion SiR-996 is a highly efficient siRNA for PTEN gene silencing in mouse primary hepatocytes.
2019 Vol. 26 (8): 22-24转28 [Abstract] ( 82 ) HTML (35 KB)  PDF  (0 KB)  ( 18 )
25 Clinical features of patients with non-syndromic multiple supernumerary teeth
SHEN Long-duo； CHANG Zheng； TANG You-chao
Objective To analyze the clinical features of non-syndromic multiple supernumerary teeth by cone beam CT and to guide treatment options.Methods The clinical data of 22 patients with non-syndromic multiple supernumerary teeth diagnosed and treated in Huizhou Stomatological Hospital from January 2015 to December 2017 were retrospectively analyzed to explore their clinical features.Results The average age of the 22 patients(98 teeth)was(27.59±9.95)years old,and the male to female ratio was 1.75：1.There were 10(10.21%)in the anterior region,79(80.61%)in the premolar region,and 9(9.18%)in the molar region.There were 31(31.63%)maxillary teeth and 67(68.37%)mandibular teeth.As to the morphology of the supernumerary teeth,8 cases(8.16%)were conical,12 cases(12.25%)were nodular,and 78 cases(79.59%)were supplementary.No dental tumor was found.Five patients(22.73%)had dental crowding and malocclusion,one patient(4.54%)had tooth cysts,and one patient(4.54%)had pulp symptoms and sinus tract.No complications such as absorption of the adjacent tooth root and excessive interdental space were found.Conclusion Non-syndromic multiple supernumerary teeth are more common in males,and more likely to occur in the mandibular premolar area.Buried supernumerary teeth are mostly close to the bone plate,which is conducive to surgical removal,but it is also easy to damage adjacent structures.Therefore,cone beam CT can be used to assist in the design of treatment plans for supernumerary teeth.
2019 Vol. 26 (8): 25-28 [Abstract] ( 75 ) HTML (42 KB)  PDF  (0 KB)  ( 13 )
29 Research status of ER,p63 and PTEN in endometrial polyps
CAI Jian; ZHENG Liu-ting; LIN Xiu-ying
Endometrial polyp is a common gynecological diseases causing abnormal uterine bleeding,the morbidity is 24%to 25%,and the recurrence rate is high.The etiology and molecular biology pathogenesis remain still unclear.Currently,it is believed that endometrial polyp is associated with changes in receptor expression levels,imbalances of proliferation/apoptotic activity of endometrial cells.Studies show that serum estrogen level in patients with endometrial polyps is normal,but its local estrogen receptor levels increase.The formation of endometrial polyps may be related to increased expression of p63 and decreased expression of PTEN protein expression,which lead to the imbalance of proliferation and apoptosis in normal cells,inducing the formation of endometrial polyps.The possible roles of ER,p63,and PTEN in the development of endometrial polyps are reviewed.
2019 Vol. 26 (8): 29-30转34 [Abstract] ( 97 ) HTML (29 KB)  PDF  (0 KB)  ( 11 )
31 Research progress of psychodrama technique in the mechanism and effect of depression intervention
CHEN Jun-jun QU Yuan HU Hua▲
Psychodrama is an expressive art therapy with special techniques,such as enactment,mirror technique,role reversal.The review briefly introduces the composition of psychodrama,the principles of the main treatment techniques,the methods of use,the psychological mechanism and effect of intervention on depression.The article summarizes the psychodrama techniques through literature search and access to professional books,and reviews the literature on intervention depression.It is found that psychodrama can interfere with depression from the aspects of establishing a sense of security,venting emotions,and improving cognition and achieve the effect in improving the symptoms,cognition,social function and other effects of depressed people,aiming to provide guidance for clinical mental health workers applying psychodrama unique technology to intervention depression.
2019 Vol. 26 (8): 31-34 [Abstract] ( 87 ) HTML (37 KB)  PDF  (0 KB)  ( 10 )
35 Research progress of Heparin-free dialysis pre-flushing method in the treatment of renal failure with high-risk bleeding
DONG Zhen-yan； ZHAO Dan-feng ； SU Wei-yi
Prevention of cardiopulmonary bypass(CPB)coagulation is the key to Heparin-free dialysis in patients with renal failure and high-risk bleeding.A variety of preflushing methods have been carried out to study the factors affecting coagulation during the CPB,in which the anticoagulant effect of traditional Heparin-free dialysis with physiological saline preflushing in vitro has been recognized.With the continuous improvement of preflushing method,Heparin physiological saline is mainly used in the closed circulation preflushing high flux dialyzer to close circulation preflushing dialyzer and tube,so that Heparin fully adsorbs dialysis membrane and tube.Heparinization during CPB can effectively reduce extracorporeal circulation coagulation and the dialysis process does not need normal saline to flush dialyzer and tube.It can not only reduce the blood volume load of patients,but also reduce the workload of nurses and improve the quality of nursing care and the effect of dialysis.The methods of Heparin-free dialysis in the treatment of renal failure with high risk bleeding in recent years are reviewed as follows.
2019 Vol. 26 (8): 35-37 [Abstract] ( 81 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
38 Clinical effect of Edaravone combined with hyperbaric oxygen in the treatment of ischemic stroke
SONG Zhu-yin； XING Xiao-na
Objective To explore the clinical Effect of edaravone combined with hyperbaric oxygen in the treatment of ischemic stroke.Methods A total of 80 patients with ischemic stroke admitted to our hospital from April 2017 to November 2018 were selected as the subjects,and randomly divided into the study group and the control group,with 40 cases in each group.The patients of the two groups were treated with routine therapy,while the control group was treated with Edaravone,the study group was treated with hyperbaric oxygen on the basis of the control group.Both groups were treated continuously for 4 weeks.The clinical effects of the two groups were observed.Results After treatment,the levels of serum matrix metalloproteinase-9 (MMP-9)in the two groups decreased,and the study group was lower than that in the control group,the levels of serum vascular endothelial growth factor(VEGF)in the two group increased,and the study group was higher than that in the control group,and the differences were statistically significant(P＜0.05).The score of national institutions of health stroke scale(NIHSS)in the two group decreased gradually from before treatment to 4 weeks after treatment,and the study group was lower than the control group at all time points after treatment,the differences wee statistically significant(P＜0.05).The total effective rate in the study group was 95.00%,which was higher than that in the control group (77.50%)(P＜0.05),and the difference was statistically significant(P＜0.05).Conclusion Edaravone combined with hyperbaric oxygen can effectively reduce the levels of serum MMP-9,increase the levels of serum VEGF,and significantly reduce the degree of 1neurological deficit in patients with ischemic stroke,and the curative effect is significant.
2019 Vol. 26 (8): 38-40 [Abstract] ( 80 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
41 Clinical effect of Isosorbide mononitrate in the treatment of patients with chronic obstructive pulmonary disease with abnormal N-terminal brain natriuretic peptide
FANG Xiu-zhen； LIU Yi-wen； FU Mei-fang； ZHANG Chuan-lin
Objective To analyze the clinical effect of Isosorbide mononitrate in the treatment of patients with chronic obstructive pulmonary disease(COPD)with abnormal N-terminal brain natriuretic peptide(BNP).Methods From July to December in 2018,60 patients with COPD with abnormal BNP treated in our department were selected as the subjects,and divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with routine treatment such as anti-infection and phlegm resolving,and the observation group was treated with Isosorbide mononitrate on the basis of control group.The treatment effects were compared.Results After treatment,the level of BNP in the two groups was decreaced,and the observation group was significantly lower than that in the control group (P＜0.05).The blood oxygen saturation and partial pressure of oxygen in the observation group were significantly higher than those in the control group,and the partial pressure of blood carbon dioxide was significantly lower than that in the control group (P＜0.05).The total effective rate of treatment in the observation group was 93.33%,which was higher than that in the control group(73.33%)(P＜0.05).The hospitalization time of the observation group was significantly shorter than that of the control group (P＜0.05).There were no obvious adverse reactions in the control group.The incidence of adverse reactions in the observation group was 6.67%,and there was no significant difference between the two groups(P＞0.05).Conclusion Isosorbide mononitrate therapy for patients with COPD with abnormal BNP can significantly improve the therapeutic effect,decrease the level of BNP,improve the blood gas analysis index and shorten the course of disease.
2019 Vol. 26 (8): 41-43转47 [Abstract] ( 97 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
44 Application effect of endoscopic precision esophagogastric varices in the diagnosis of esophagogastric varices bleeding
CHEN Yan-qiong
Objective To investigate the effect and safety of endoscopic precision esophagogastric varices in the diagnosis of esophagogastric varices bleeding.Methods Sixty patients with esophageal varices bleeding from January 2016 to August 2017 treated in our hospital were selected as the subjcts,and divided into study group (n=30)and control group (n=30)by random number table method.The control group was treated with conventional sequential injection,and the study group underwent endoscopic precision esophagogastric varices.The treatment status of the two groups(treatment time,blood loss during treatment,hospitalization time),treatment effect,and complication rate were counted.Results There was no significant difference in the treatment time,blood loss and hospitalization time between the two groups(P＞0.05).The total effective rate of treatment in the study group was 86.67%(26/30),which was higher than the control group for 63.33% (19/30)(P＜0.05).There was no significant difference in the total incidence of complications between the two groups(P＞0.05).Conclusion Endoscopic precision esophagogastric varices surgery for esophageal and gastric varices bleeding can effectively improve the overall treatment of the disease,and the incidence of complications is no different from traditional treatment.
2019 Vol. 26 (8): 44-47 [Abstract] ( 98 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
48 Significance of β-type brain natriuretic peptide,D-dimer and procalcitonin in the assessment of condition and near-and long-term treatment prognosis of elderly patients with chronic obstructive pulmonary disease
CHEN Jian; LIN Yong-ping
Objective To investigate the significance of β-type brain natriuretic peptide,D-dimer and procalcitonin in the assessment of condition and near-and long-term treatment prognosis prognosis of elderly patients with chronic obstructive pulmonary disease(COPD).Methods A total of 100 patients with COPD admitted to our hospital from January 2016 to June 2017 were enrolled as the observation group.100 healthy subjects were selected as the control group according to the 1：1 pairing principle.the Pulmonary function index (first forced forced expiratory volume[FEV1],forced vital capacity[FVC],one second rate[FEV1/FVC])and the biochemical indicators(beta-type brain natriuretic peptide[BNP],D-dimer[DD],procalcitonin[PCT])were performed.The lung function and biochemical indicators in observation group and control group were compared,the patients in the observation group were divided into 1,2,3,and 4 groups according to the estimated FEV1%of lung function,then the biochemical indicators between different subgroups were compared.The first hospitalization time (recent prognosis index)and the number of rehospitalization(long-term prognostic indicators)were recorded in the statistical observation group,and the correlation between biochemical indicators and prognosis was analyzed.Results The pulmonary function indexes FEV1,FVC and FEV1/FVC in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).The PCT,D-D,BNP of the observation group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).There were significant differences in PCT,D-D and BNP levels among patients with grades 1,2,3 and 4 (P＜0.01),the PCT,D-D and BNP levels in grades 3 and 4 were higher than grades 1 and 2 (P＜0.05).The first hospitalization time in CysC,D-D,BNP positive group was significantly longer than that in the negative group (P＜0.05).The number of re-hospitalization during the follow-up period in CysC,D-D,BNP positive group was significantly more than that in the negative group(P＜0.05).The PCT,DD,BNP were positively correlated with the time of first hospitalization (r=0.393,0.457,0.504,P＜0.05),and the PCT,D-D,BNP were positively correlated with the number of rehospitalization(r=0.308,0.286,0.488,P＜0.05).Conclusion BNP,D-D and PCT can be used as sensitive indicators for the evaluation of disease status and prognosis of elderly patients with COPD,whic have high clinical value.
2019 Vol. 26 (8): 48-51 [Abstract] ( 82 ) HTML (40 KB)  PDF  (0 KB)  ( 13 )
52 Effect comparison of two surgical procedures in the treatment of calculus of bile duct
GAO Lü-lin
Objective To study the effect of two surgical procedures in the treatment with calculus of bile duct.Methods A total of 56 patients with calculus of bile duct greater than 1.0 cm treated in our hospital from January 2013 to December 2017 were selected as subjects.They were divided into control group(28 cases)and observation group(28 cases)according to the double-blind randomization principle.The control group was treated with endoscopic retrograde pancreatography (ERCP)for stone removal in the Department of Gastroenterology.The observation group was treated with laparoscopic combined with choledochoscopy in the Department of General Surgery.The clinical effects,operation time,intraoperative blood loss,postoperative blood amylase,postoperative bleeding and incidence of pancreatitis,postoperative residual stones,postoperative pain,eating time,hospital stay,total incidence of postoperative complications were compared between the two groups.Results The total clinical effective rate of patients in the observation group was higher than that of the control group (P＜0.05).The operation time of patients in the observation group was longer than that of the control group,the intraoperative blood loss was less than that of the control group,the postoperative blood amylase was lower than the control group,and the differences were statistically significant(P＜0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in postoperative pain scores,eating time and hospitalization time between the two groups (P＞0.05).Conclusion Laparoscopic combined with choledochoscopy for the treatment of patients with calculus of bile duct greater than 1.0 cm is superior to ERCP,which can be used as the first choice for clinical treatment.
2019 Vol. 26 (8): 52-54 [Abstract] ( 84 ) HTML (33 KB)  PDF  (0 KB)  ( 14 )
55 Clinical observation of Shufeng Jiedu Capsule combined with antibiotics in the treatment of acute exacerbation of chronic bronchitis
WEI You-liang
Objective To explore the clinical effect of Shufeng Jiedu Capsule combined with antibiotics in the treatment of acute exacerbation of chronic bronchitis.Methods Thirty-six patients with acute exacerbation of chronic bronchitis treated in our hospital from March 2016 to May 2017 were selected as the subjects,and divided into control group(18 cases)and study group(18 cases)according to the random number table method.The control group was only treated with Levofloxacin Capsules,while the research group was treated with Shufeng Jiedu Capsule on basis of the control group.The clinical efficacy,symptoms and signs,procalcitonin(PCT)and C-reactive protein(CRP)levels were compared between the two groups.Results After treatment,the total effective rate of the study group(94.44%)was higher than that of the control group (66.67%),and the difference was statistically significant(P＜0.05).The improvement time of the symptoms and signs in the study group were shorter than those of the control group,and the differences were statistically significant(P＜0.05).Before treatment,the PCT and CRP levels of the two groups were not significantly different(P＞0.05).After treatment,the PCT and CRP levels of the two groups were lower than those before treatment,and the PCT and CRP levels of the study group were lower than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion Shufeng Jiedu Capsule combined with antibiotic regimen is helpful to alleviate inflammation in patients with acute exacerbation of chronic bronchitis,thereby accelerating the improvement of symptoms and signs,and improving the recovery level of the body.
2019 Vol. 26 (8): 55-57 [Abstract] ( 117 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
58 Analysis of clinical features of 69 cases of bacterial liver abscess
LIU Xian-xian; CHENG Jin-ying; WANG Lu-lu; TIAN Wen-chao

Objective To summarize and analyze the clinical features of bacterial liver abscess and provide evidence for rational diagnosis and treatment.Methods The clinical data of 69 cases patients with bacterial liver abscess treated in our hospital from January 2015 to December 2017 were retrospectively analyzed and descriptively studied.Results The average age of patients was(56.53±12.88)years old.The highest peak age of bacterial liver abscess onset was 50-69 years old(59.42%).There were 58 patients with one or more underlying diseases and mostly complicated with diabetes mellitus(n=32,46.38%).The main clinical manifestations of patients with liver abscess were fever(n=62,89.86%),followed by fear of cold and chills(n=42,60.87%)and right upper quadrant pain(n=29,40.03%).Among the patients,single-lumen right lobe abscess was common(n=52,75.36%).The percentages of neutrophils increase and albumin reduction were the most remarkable in laboratory abnormalities,92.75%(64/69)and 78.26%(54/69),respectively.Twenty-four patients underwent blood culture and 15 were positive (62.50%).Thirty-six patients underwent bacteriological culture from pus puncturing and 29 were positive(80.56%).The blood culture and pus culture results were Klebsiella pneumonia in 5 patients.The treatment method is mainly based on antibacterial drugs combined with percutaneous puncture drainage.Forty patients were cured and 26 ones were improved,with a total effectiveness rate of 95.65%.Conclusion Bacterial liver abscess occurs in middle-aged and elderly people.The main clinical manifestations are high fever,fear of cold and chills,right upper quadrant pain.The main pathogen is Klebsiella pneumoniae.Perfect abdominal color Doppler ultrasound and upper abdominal CT can assist in the early diagnosis of bacterial liver abscess.
2019 Vol. 26 (8): 58-61 [Abstract] ( 105 ) HTML (37 KB)  PDF  (0 KB)  ( 12 )
62 Effect of percutaneous full spinal endoscopic precision decompression in the treatment of degenerative lumbar stenosis
YANG Xue-jun; CHEN Xiao-dong; WEI Chen-qiang; SHU Gao; LIANG Peng-zhan
Objective To investigate the effect of percutaneous full spinal endoscopic precision decompression in the treatment of degenerative lumbar spinal stenosis.Methods A total of 35 patients with degenerative lumbar spinal stenosis admitted to our hospital from January 2015 to March 2017 were selected as the objects,according to the different treatment schemes,the patients were divided into the observation group(19 cases)and the control group(16 cases).The observation group was treated with percutaneous full spinal endoscopic precision decompression,while the control group performed traditional laminectomy decompression therapy.The therapeutic effects (including digital pain assessment[NRS]score and Oswestry functional dysfunction index questionnaire[ODI]index)and surgical related conditions(including intraoperative bleeding,hospitalization time and complications)were compared between the two groups.Results The NRS score and ODI index of 1 month and 1 year after treatment in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).The blood loss in the observation group was less than that of the control group,and the hospitalization time in the observation group was shorter than that of the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in total incidence of complications between the two groups (P＞0.05).Conclusion Percutaneous full spinal endoscopic precision decompression is safe and effective in the treatment of degenerative lumbar spinal stenosis,which can effectively alleviate the related symptoms.
2019 Vol. 26 (8): 62-64 [Abstract] ( 92 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
65 Clinical effect of mini-locking plate through tarsal sinus approach in the treatment of calcaneal sanders typeⅡandⅢfractures
LU Zhi-feng; WANG Hai-feng; ZENG Hui-ling
Objective To explore the clinical effect of mini-locking plate through tarsal sinus approach in the treatment of calcaneal sandersⅡandⅢfractures.Methods Altogether 60 cases of calcaneal sanders typeⅡand typeⅢfractures who were admitted to the Second Traditional Chinese Medicine Hospital of Meizhou City and Chengdong Town Health Hospital of Meixian District of Meizhou City from June 2016 to June 2018 were selected as the study subjects and randomly divided into the control group and the observation group,30 cases in each group.The control group was treated with prying reduction and external fixation with Kirschner nail,and the observation group was treated with mini-locking plate treatment via sinus approach.The patients were followed up post-operatively for 3 months to understand the healing of fracture,and to observe whether the patients had incision infection and skin necrosis.At the same time,ankle and foot function scoring system(AOFAS)was used to evaluate the post-treatment foot function of patients.Results After 3-month follow-up,the healing rate of fracture of the observation group was 100.00%,which was higher than 66.67%of the control group,the difference was statistically significant(P＜0.05).The incision infection and skin necrosis rate of the observation group were lower than those of the control group,with statistically significant difference (P＜0.05).The excellent rate of sanders typeⅡand typeⅢpatients of the observation group was higher than that of the control group,with statistically significant difference (P＜0.05).Conclusion Application of mini-locking plate through tarsal sinus approach in the treatment of calcaneal sanders typeⅡand typeⅢfractures can avoid complications such as necrosis of skin flap and infection of incision after operation,which is worthy of clinical promotion in the future.
2019 Vol. 26 (8): 65-67 [Abstract] ( 83 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
68 Feasibility and application value of preserving left colon artery in laparoscopic anterior resection of rectal cancer
LI Zhi-wang ; WU Zu-guang; LI En; LIU Hong-tao; ZHANG Zhuo-xin
Objective To explore the feasibility and application value of preserving left colon artery (LCA)in laparoscopic anterior resection of rectal cancer.Methods A total of 167 patients with rectal cancer who underwent laparoscopic anterior resection of rectal cancer in our hospital from December 2016 to June 2018 were randomly divided into study group(83 cases)and control group(84 cases).The LCA was preserved in the study group,while the LCA was not preserved in the control group.The amount of bleeding during operation,the time of exhaust after operation,the occurrence of anastomotic leakage after operation,the number of lymph node dissection,the time of operation,the occurrence of free splenic curvature and ileostomy were compared between the two groups.Results There were no significant differences in operation time,intraoperative blood loss,number of lymph node dissection,exhaust time and incidence of ileostomy between the two groups (P＞0.05).The incidence of anastomotic leakage in the study group was lower than that in the control group,the difference was significant(P＜0.05).The incidence of free splenic flexure in the study group was lower than that in the control group,the difference was significant(P＜0.05).Conclusion Laparoscopic anterior resection of rectal cancer with LCA preservation can reduce the incidence of anastomotic leakage and ensure the normal blood supply of anastomotic stoma.
2019 Vol. 26 (8): 68-70 [Abstract] ( 66 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
71 Clinical study of transcatheter arterial chemoembolization combined with microwave ablation in the treatment of liver cancer
LU Qin-rong
Objective To investigate the clinical effect of transcatheter arterial chemoembolization (TACE)combined with microwave ablation in the treatment of liver cancer.Methods Thirty-six patients with liver cancer admitted to our hospital from June 2014 to October 2015 were selected as the study subjects,they were divided into control group and study group according to random number table method,with 18 cases in each group,the control group was treated with TACE and the study group was treated with TACE combined with microwave ablation.The short-term and long-term effects of the two groups were compared.Results The total necrosis rate of tumors(83.33%)in the study group was significantly higher than that in the control group(16.67%)after 2 months of treatment,the difference was significant(P＜0.05).The partial necrosis rate (16.67%)in the study group was significantly lower than that in the control group(83.33%)after 2 months of treatment,the difference was significant(P＜0.05).The one-year survival rate of the study group(83.33%)was significantly higher than that of the control group(44.44%),the difference was significant(P＜0.05).The two-year survival rate of the study group(44.44%)was significantly higher than that of the control group(5.56%),the difference was significant(P＜0.05).Conclusion TACE combined with microwave ablation in the treatment of liver cancer has a high rate of complete necrosis and good short-term and long-term efficacy,which is worthy of clinical application.
2019 Vol. 26 (8): 71-73 [Abstract] ( 69 ) HTML (30 KB)  PDF  (0 KB)  ( 13 )
74 Clinical effect of Docetaxel and Lobaplatin combined with radiotherapy in the treatment of middle late stage esophageal cancer
GUO Feng
Objective To investigate the clinical effect of Docetaxel and Lobaplatin combined with radiotherapy in the treatment of middle late stage esophageal cancer.Methods Eighty patients with middle late stage esophageal cancer admitted to our hospital from January to December 2015 were selected as the research objects,they were divided into control group and observation group according to different treatment methods,with 40 cases in each group.Patients in the control group were given radiotherapy only,while patients in the observation group were given Docetaxel+Lobaplatin+radiotherapy,the total effective rate of clinical treatment,the total incidence of complications and the survival rate of 1,2 and 3 years were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group,the difference was significant(P＜0.05).There was no significant difference in the total incidence of complications between the two groups(P＞0.05).The 1,2 and 3 years survival rates of the patients in the observation group were 80.00%,65.00%and 50.00%respectively,which were significantly higher than 57.50%,42.50%and 27.50%,respectively in the control group,the differences were significant(P＜0.05).Conclusion Docetaxel and Lobaplatin combined with radiotherapy can improve the clinical efficacy and survival rate of patients with middle late stage esophageal cancer,which is worthy of clinical promotion.
2019 Vol. 26 (8): 74-76 [Abstract] ( 84 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
77 Effect of Thalidomide on peripheral blood regulatory T cells in the treatment of patients with acute leukemia
LI Ju-heng ; ZHAO Ying-ling▲
 To investigate the effect of Thalidomide on peripheral blood regulatory T cells in the treatment of patients with acute leukemia.Methods Sixty patients with acute myeloid leukemia(AML)admitted to our hospital from January 2014 to January 2018 were selected as the subjects,they were randomly divided into routine group (30 cases)and experimental group(30 cases),the routine group was treated with basic chemotherapy,the experimental group was treated with Thalidomide,and 30 healthy people were selected as the healthy group in the same period.The total effective rate of experimental group and routine group of patients were compared,the levels of CD4+CD25+T lymphocyte in three groups were compared at different time points,the levels of CD3+T lymphocyte,CD4+T lymphocyte,CD4+/CD8+ratio and NK cell in peripheral blood of three groups were compared at different time points.Results The total effective rate of the experimental group was higher than that of the routine group,the difference was significant(P＜0.05).The levels of CD4+CD25+T lymphocyte in the experimental group were higher than those in the healthy group at T1and T2time,the difference was statistically significant(P＜0.05).The levels of CD4+CD25+T lymphocyte in the experimental group were lower than those in the routine group at the time of T2and T3,the difference was statistically significant(P＜0.05).The levels of CD3+T lymphocyte,CD4+T lymphocyte,CD8+T lymphocyte,CD4+/CD8+ratio and NK cell in peripheral blood of the experimental group were lower than those of the healthy group at T1time,the difference was statistically significant(P＜0.05).The levels of CD3+T lymphocyte,CD4+T lymphocyte and NK cell in peripheral blood of the experimental group were higher than those of the routine group at T3time,the difference was statistically significant(P＜0.05).Conclusion Thalidomide can improve the cellular immune function of AML patients and improve the therapeutic effect.
2019 Vol. 26 (8): 77-80 [Abstract] ( 77 ) HTML (47 KB)  PDF  (0 KB)  ( 12 )
81
Detection value of Epstein-Barr virus in peripheral blood of patients with different types of lymphoma
 
Detection value of Epstein-Barr virus in peripheral blood of patients with different types of lymphoma
 
[J]. 中国当代医药, 2019,26(8): 81-83')" href="#">		 ZENG Yan ; LIU Yu
Objective To investigate the detection value of Epstein-Barr virus (EBV)in peripheral blood of patients with different types of lymphoma.Methods The clinical data of 80 patients with lymphoma diagnosed in our hospital from January to December 2017 were retrospectively analyzed,the EBV in peripheral blood was detected by PCR,and the positive expression of EBV in different types of lymphoma and different clinical stages was analyzed.Results The positive expression rate of EBV-DNA in T,NK/T cell-derived lymphoma patients (72.0%)was higher than that in B cell-derived lymphoma patients(40.0%),the difference was statistically significant(P＜0.05).The positive expression rate of EBV-DNA in patients with Ann Arbor stageⅠ-Ⅱ (34.4%)was significantly lower than that in patients with stageⅢ-Ⅳ (62.5%)(P＜0.05).Conclusion The expression of EBV-DNA in peripheral blood of patients with different types of lymphoma is different.Detection of EBV-DNA in peripheral blood can be used as an important reference index to evaluate the prognosis of lymphoma and has certain clinical value.
2019 Vol. 26 (8): 81-83 [Abstract] ( 78 ) HTML (30 KB)  PDF  (0 KB)  ( 11 )
84 Effect of modified Shashen Maidong Decoction combined with chemotherapy on immune function in patients with lung cancer
ZHANG Xin-ting
Objective To explore the effect of modified Shashen Maidong Decoction combined with chemotherapy on Immune Function in patients with lung cancer.Methods A total of 66 patients with lung cancer admitted to our hospital from June 2015 to January 2018 were selected as the research objects,they were randomly divided into control group(33 cases)and observation group(33 cases).The control group was treated with routine chemotherapy,while the observation group was treated with Shashen Maidong Decoction on the basis of chemotherapy.The changes of immune function,total incidence of adverse reactions and quality of life (KPS)scores were compared between the two groups.Results The levels of CD3+and CD4+in the observation group after treatment were higher than those in the control group,the difference was significant(P＜0.05).There were no significant differences in NK and CD8+levels between the two groups(P＞0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was significant(P＜0.05).The KPS score of the observation group after treatment was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion The effect of modified Shashen Maidong Decoction combined with chemotherapy for lung cancer patients is remarkable.It can effectively improve the related indicators of immune function,reduce the occurrence of adverse reactions and improve the quality of life of patients.
2019 Vol. 26 (8): 84-86 [Abstract] ( 76 ) HTML (35 KB)  PDF  (0 KB)  ( 11 )
87 Study on correlation between visfatin level and polycystic ovary syndrome
ZHANG Wen-bo; LI Bao-yan
Objective To investigate the correlation between visfatin level and polycystic ovary syndrome(PCOS).Methods A total of 30 patients with PCOS from February 2016 to June 2018 in the Gynecological Clinic of People′s Hospital of Luohu District in Shenzhen City were selected as the experimental group,they were divided into the PCOS obesity group(10 cases)and the PCOS non-obesity group(20 cases).Meanwhile,30 normal women in the physical examination center were selected as the control group.The control group was divided into the control obesity group(10 cases)and the control non-obesity group(20 cases).The general data,plasma visfatin concentration,insulin concentration,blood glucose concentration and testosterone content of each group were compared,and the relationship between each factor and visfatin was further analyzed.Results There was no significant difference in age and height between all groups(P＞0.05).The levels of testosterone,insulin and visfatin in the PCOS obesity group and the PCOS non-obesity group were significantly higher than those in the control obesity group and the control non-obesity group,with significant difference (P＜0.05).Pearson correlation analysis showed that serum visfatin content was positively correlated with BMI,WHR,testosterone concentration and insulin content(r=0.308,0.179,0.359,0.352,P＜0.05).Conclusion As a kind of adipose cytokine,visfatin plays an important role in the pathogenesis of PCOS.It is not only one of the clinicopathological characteristics of PCOS,but also closely related to obesity,insulin resistance and hyperandrogenism.Meanwhile,visfatin can affect the occurrence and development of many metabolic diseases,such as PCOS.
2019 Vol. 26 (8): 87-89 [Abstract] ( 75 ) HTML (30 KB)  PDF  (0 KB)  ( 15 )
90 Effects of pregnancy exercise combined with nutritional intervention on improving the natural labour rate of the second pregnant of scar uterus
LIU Zhu-jun
Objective To investigate the effect of pregnancy exercise combined with nutritional intervention on improving the natural labour rate of the second pregnant of scar uterus.Methods A total of 110 cases of the second pregnant women with scar uterus who were admitted to department of obstetrics and gynecology of three general hospitals in Huizhou city from August 2017 to August 2018 were selected as the study subjects.According to the random number table method,they were divided into the study group(n=55)and the control group(n=55).The control group was given routine maternity examination,psychological and lifestyle guidance,while the study group was given pregnancy exercise and nutritional intervention.The weight gain of pregnant women,mode of delivery,duration of labor,neonatal Apgar score,neonatal birth weight and pregnancy complications observed and compared between the two groups.Results The average weight gain of pregnant women in the study group was lower than that in the control group,and the coincidence rate of weight gain in the study group was significantly higher than that in the control group (P＜0.05).The natural labour rate of the second pregnant women in the study group was 94.55%,which was significantly higher than 52.73%in the control group(P＜0.05).The first stage of labor and the second stage of labor time in the study group were shorter than those in the control group (P＜0.05).There was no significant difference between the two groups in the third stage of labor time (P＞0.05).The Apgar score of newborns in the study group was higher than that in the control group (P＜0.05),while the birth weight of newborns in the study group was lower than that in the control group(P＜0.05).The total incidence of pregnancy complications in the study group was lower than that in the control group(P＜0.05).Conclusion Pregnancy exercise combined with nutritional intervention can improve the natural labour rate of the second pregnant women with scar uterus,shorten the labor process,reduce the incidence of pregnancy complications during pregnancy.
2019 Vol. 26 (8): 90-92 [Abstract] ( 90 ) HTML (36 KB)  PDF  (0 KB)  ( 15 )
93 Application effect of postpartum contraceptive care services in puerpera
KONG Hai-yan; ZOU Lin-zhi; XIAO Yu-hong; JIANG Yan-hua
Objective To explore the role of postpartum contraceptive care services in reducing the short-term unintended re-pregnancy rate and increasing exclusive breastfeeding rate of pregnant women after childbirth.Methods A total of 66 healthy puerpera who were admitted to the department of obstetrics and gynecology in our hospital from April 2016 to April 2017 were selected as research objects and divided into the experimental group and the control group according to the method of random number table,33 cases in each group.The control group was given routine postpartum health education,and the experimental group was given postpartum contraceptive care services on the basis of the control group.The contraceptive measures implemented within one year after delivery,the rate of unintended repregnancy within one year,the rate of induced abortion and breastfeeding were compared between the two groups.Results Contraceptives and intrauterine birth control rings were used as the main contraceptive measures in the two groups.The total rate of contraceptive measures implemented in the experimental group was 93.94%,which was significantly higher than that in the control group(81.82%),with statistically significant difference(P＜0.05).The rate of unintended re-pregnancy and the rate of induced abortion in the experimental group within one year were significantly lower than those in the control group,with statistically significant differences(P＜0.05).The maternal breastfeeding rate of the experimental group was 81.82%,which was significantly higher than that of the control group (69.70%),and the difference was statistically significant(P＜0.05).Conclusion Postpartum contraceptive care services can significantly reduce the short-term unintended re-pregnancy rate of pregnant women after childbirth,significantly improve the rate of exclusive breastfeeding,and the effect is significant,which is worthy of clinical promotion and application.
2019 Vol. 26 (8): 93-95 [Abstract] ( 79 ) HTML (30 KB)  PDF  (0 KB)  ( 15 )
96 Clinical effect of Metformin in the treatment of insulin resistance patients with recurrent spontaneous abortion
ZHANG Yan-ni; ZHOU Zi-qiu; ZHONG Cui-ping
Objective To observe the clinical effect of Metformin in the treatment of recurrent spontaneous abortion(RSA)combined with insulin resistance(IR).Methods A total of 100 IR patients with RSA in our hospital from January 2016 to January 2018 were selected.According to treatment options,they were divided into the control group(48 cases)and the observation group (52 cases).The control group received oral Metformin Tablets before pregnancy,stopping Metformin after pregnancy,and Progesterone was used for treatment.The observation group continued to take Metformin Tablets after pregnancy on the basis of the control group.The changes of homeostasis model of assessment for insulin resistence index (HOMA-IR)before and after treatment were observed between the two groups.The pregnancy outcomes and adverse reactions of the two groups were also recorded.Results After treatment,the HOMA-IR of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P＜0.05).The incidence rate of abortion and the total incidence rate of adverse reactions in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Metformin in the treatment of IR patients with RSA has good clinical effect and good safety,which can effectively improve the patients′IR and reduce the abortion rate.
2019 Vol. 26 (8): 96-98 [Abstract] ( 63 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
99 Influence of vitamin D on blood glucose and pregnancy outcome in normal body mass index patients with gestational diabetes mellitus
YUE Xiao-ling; ZHAN Fang; ZHANG Qian
Objective To explore the influence of vitamin D(VD)on blood glucose and pregnancy outcome in pregnant women with gestational diabetes mellitus (GDM).Methods From January 2016 to January 2017,280 cases of GDM pregnant women with VD deficiency (＜20 ng/ml)admitted to our hospital were selected as the research object.According to the random method,they were divided into the experimental group and the control group,140 cases in each group.The experimental group was given medical nutrition therapy (MNT)and oral VD 1200 IU/d,and the control group was given MNT and oral VD 400 IU/d.Blood glucose and pregnancy outcomes were compared between the two groups.Results Compared with before treatment,the fasting plasma glucose(FPG)and postprandial 2-hour plasma glucose(2 h PG)of pregnant women in both groups decreased after treatment,and the level of 25-hydroxyvitamin D3(25-[OH]D3)increased after treatment,the difference was statistically significant (P＜0.05).The level of FPG,2 h PG,HbA1c and the incidence rate of hypertension during pregnancy,polyhydramnios,fetal distress,forceps delivery rate,premature delivery,postpartum hemorrhage,prolonged or stagnation labor,neonatal asphyxia,macrosomia in the experimental group were significantly lower than those in the control group,with significant difference (P＜0.05).The rate of spontaneous delivery and the level of 25-(OH)D3in the experimental group was significantly higher than that in the control group,and the difference was significant(P＜0.05).There were no statistically significant differences in the incidence rates of cesarean section,stillbirth,low birth weight children and neonatal hypoglycemia between the two groups(P＞0.05).Conclusion VD is helpful to control the blood glucose of GDM pregnant women,reduce some complications during pregnancy and improve pregnancy outcomes.
2019 Vol. 26 (8): 99-102 [Abstract] ( 74 ) HTML (38 KB)  PDF  (0 KB)  ( 12 )
103 Effect of Drospirenone and Ethinylestradiol Tablets in the postoperative endometrial repair for missed abortion patients undergoing the curettage
LIU Xue-jing; WANG Xiao-rong
Objective To discuss the effect of Drospirenone and Ethinylestradiol Tablets in the postoperative endometrial repair for missed abortion patients who underwent the curettage.Methods A total of 70 missed abortion patients admitted to our hospital from January 2016 to January 2018 were selected as study objects and divided into the control group and the observation group according to random number table method,35 cases in each group.The control group was treated with general treatment,while the observation group was treated with Drospirenone and Ethinylestradiol Tablets on the basis of the control group.The therapeutic effects of the two groups were compared.Results There was no significant difference in the amount of postoperative bleeding between the two groups after operation (P＞0.05).The vaginal bleeding time,duration of abdominal pain and menstruation recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).The incidence rate of pelvic inflammatory disease in the observation group was 2.86%,which was lower than 17.14%in the control group,and the difference was statistically significant(P＜0.05).The incidence rate of menstrual disorders in the observation group was 0.00%,which was lower than that in the control group (14.29%),and the difference was statistically significant(P＜0.05).Conclusion The oral medication of Drospirenone and Ethinylestradiol Tablets can promote the endometrial repair and adjust the sex hormone,which is worthy of clinical promotion.
2019 Vol. 26 (8): 103-105 [Abstract] ( 83 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
106 Effect of the long-term home atomization inhaled Budesonide in the treatment of infants wheezing with positive asthma predictive index
CHEN Ai-qing; LIU Lin; GUAN Hua
Objective To observe the clinical effect of long-term home atomization inhaled Budesonide in the treatment of infants wheezing with positive asthma predictive index(API).Methods A total of 67 API positive patients visited the pediatric clinic at our center from January 2014 to January 2016 were selected and randomly divided into the observation group(n=34)and the control group(n=33).The observation group was treated with long-term home atomization inhaled Budesonide after acute asthma attack control,according to the effect of symptom control,the inhalation dose of Budesonide was adjusted from 1 mg/d to 0.25 mg/d.The course of treatment was from March to September.The control group was treated with high dose Budesonide suspension combined with Salbutamol Sulfate Solution and Ipratropium Bromide Solution at each wheezing attack,and the drug was discontinued after symptom control.Following up for 12 months,the number of wheezing relapses,duration of wheezing attacks and the use rate of systemic corticosteroids in severe wheezing attacks were observed and compared between the two groups.Results The recurrence times of wheezing in the observation group was(1.5±0.3)times,which was significantly less than(3.5±0.6)times in the control group,the difference was statistically significant(P＜0.05).The duration of wheezing attacks in the observation group was (3.7±0.8)days,which was shorter than (6.2±0.6)days in the control group,the difference was statistically significant(P＜0.05).The use rate of systemic corticosteroids in the observation group was 6.3%,which was significantly lower than that in the control group(15.1%),the difference was statistically significant(P＜0.05).After the course of treatment,there were no obvious adverse reactions in both groups.Conclusion Long-term home atomization inhaled Budesonide can effectively prevent the recurrence of asthma and alleviate the degree of asthma attack in API positive infants and young children,the curative effect is remarkable and the safety is good.
2019 Vol. 26 (8): 106-108 [Abstract] ( 66 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
109 Analysis of platelet and blood coagulation function on the first day of birth in neonates with different birth weight
YANG Shi-mei; WEI Chun-hui; ZHANG Yan-shun
Objective To study the clinical significance of the platelet(PLT)and blood coagulation function on the first day of birth in neonates with different birth weight.Methods A total of 200 newborns born in our hospital from January to October in 2017 were selected as study object,then they were divided into the very low birth weight infant group(32 infants),the low birth weight group(58 infants),the normal birth weight infant group(69 infants),and the macrosomia infant group (41 infants).Altogether 50 full-term neonates during the same period were selected as the control group.The platelet and blood coagulation function were examined in each group within the first day after birth,and the PLT and blood coagulation function of the newborns in each group were compared.Results There was statistically significant difference in the level of PLT,prothrombin time(PT),prothrombin time activity(PTA),international normalized ratio(INR)and activated partial thromboplastin time(APTT)among each groups(P＜0.05).There was no significant difference in thrombin time (TT)and fibrinogen (FIB)levels among groups (P＞0.05).The PLT level of the very low birth weight infant group was lower than that of the low birth weight infant group,the normal birth weight infant group,the macrosomia infant group and the control group,the difference was statistically significant(P＜0.05).The levels of PT,INR and APTT in the very low birth weight infant group were higher than those in the low birth weight infant group,the normal birth weight infant group,the macrosomia infant group and the control group,the difference was statistically significant(P＜0.05).Conclusion Abnormal in PLT and coagulation function on the first day of birth may be one of the indicators of increased risk of intraventricular hemorrhage in very low birth weight infants.
2019 Vol. 26 (8): 109-111 [Abstract] ( 79 ) HTML (30 KB)  PDF  (0 KB)  ( 6 )
112 Value of gastroscopy in the diagnosis of Helicobacter pylori infection associated gastritis in children
XU Jin-hui
Objective To analyze the diagnostic value of gastroscopy for Helicobacter pylori(Hp)infection associated gastritis in children.Methods A total of 156 patients with suspected pediatric gastritis admitted to our hospital from January to August in 2018 were selected as the study subjects.According to whether the patient agreed to use gastroscopy and the results of the examination were randomly divided into group A(66 cases),group B(14 cases),group C(76 cases).Group A agreed to use gastroscopy and positive for Hp,group B agreed to use gastroscopy and negative for Hp,group C did not agree to use gastroscopy.All three groups were given routine treatment of gastritis,such as namely health education,life restraint,at the same time,acid inhibitors,antibiotics and gastric mucosal protective drugs were given,and gastrointestinal motility drugs were added when necessary.In addition,the children in group A were treated with anti-Hp therapy according to the clinical antibiotics,proton pump inhibitors(PPI)and bismuth agents.The children with severe Hp infection were treated with Amoxicillin,Clarithromycin,Omeprazole and Bismuth Potassium Citrate.The course of treatment was 2 weeks.After one month of treatment,the clinical manifestations and signs of the three groups were compared,and the therapeutic effect was evaluated by pathological examination.Results There was no significant difference in the inflammation and activity of gastric mucosa between group A and group B before treatment(P＞0.05).The severity degree of inflammation in group A was significantly lower than that in group B after treatment,the difference was statistically significant(P＜0.05).The degree of abdominal pain and tenderness in group A was significantly lower than that in group C,the difference was statistically significant(P＜0.05).The degree of abdominal pain and tenderness in group B was significantly lower than that in group C,the difference was statistically significant(P＜0.05).There was no significant difference in the degree of vomiting and anorexia among the three groups(P＞0.05).Conclusion Gastroscopic examination can identify the specific causes of gastritis in children,and it has important diagnostic value for clinical treatment of pediatric gastritis.
2019 Vol. 26 (8): 112-115 [Abstract] ( 77 ) HTML (37 KB)  PDF  (0 KB)  ( 12 )
116 Effect of combined application of Carboprost Tromethamine,Carboprost Suppository and Oxytocin in the treatment of postpartum hemorrhage
OU Jia-min
Objective To explore the effect of combined application of Carboprost Tromethamine,Carboprost Suppository and Oxytocin in the treatment of postpartum hemorrhage.Methods A total of 40 cases of high risk of postpartum hemorrhage in our hospital from August 2015 to August 2018 were selected as the research objects.According to the time of admission,they were divided into the control group(20 cases)and the observation group(20 cases).The control group was treated with Oxytocin combined with Carboprost Suppository,and the observation group was treated with Carboprost Tromethamine+Carboprost Suppository+Oxytocin.The amount of bleeding after delivery,2 hours after delivery and 24 hours after delivery,the total amount of bleeding and the decrease value of hemoglobin in 24 hours after delivery were compared between the two groups,and the total incidence of adverse reactions was compared between the two groups.Results There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).The amount of bleeding during and after operation in the observation group was less than that in the control group,with significant difference (P＜0.05).The decrease of hemoglobin in 24 hours in the observation group was significantly lower than that in the control group,with significant difference(P＜0.05).Conclusion In the high-risk patients of postpartum hemorrhage,the therapeutic effect of using Carboprost Tromethamine,Oxytocin and Carboprost Suppository is obviously better than that of Oxytocin combined with Carboprost Suppository.It can significantly reduce the amount of postpartum hemorrhage of parturients.The clinical effect is exact and will not have a greater impact on the health of patients.The application effect is very satisfactory.It is worth recommending.
2019 Vol. 26 (8): 116-118 [Abstract] ( 73 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
119 Value analysis of Vitamin D Drops in the prevention of active rickets in children
CHENG Zhen-hua
Objective To investigate the value of Vitamin D Drops in the prevention of active rickets in children.Methods A total of 300 active rickets preventive medication children admitted to our hospital from January 2016 to October 2017 were enrolled in the study.According to the random number table method,they were divided into the observation group(150 cases)and the control group(150 cases).The control group was given Calcium Carbonate Particles to prevent active rickets,the drug was administered for half a year.The observation group was given Calcium Carbonate Granules and Vitamin D Drops to prevent active rickets and continued to use drugs for half a year.The level of serum biochemical parameters such as 25-(OH)D3,serum calcium,blood phosphorus,DPD,BALP were compared between the two groups.The incidence of adverse reactions,the level of 25-(OH)D3,the incidence of active rickets,bone mineral density and BALP at 1 year follow-up were recorded between the two groups.Results There was no significant difference in the level of 25-(OH)D3,serum calcium,serum phosphorus,DPD and BALP between the two groups (P＞0.05).The level of 25-(OH)D3,serum calcium,serum phosphorus,DPD and BALP in the observation group after treatment were higher than those in the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P＞0.05).The level of 25-(OH)D3,bone mineral density and BALP at 1 year follow-up in the observation group were higher than those in the control group,and the incidence of active rickets in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Vitamin D Drops have a good value in preventing active rickets in children.It can also improve serum biochemical indicators and bone density in children,which has high safety,and is worthy of application.
2019 Vol. 26 (8): 119-121 [Abstract] ( 70 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
122 Clinical effect of anti-early pregnancy drugs combined with uterine curettage on missed abortion
SUN Li
Objective To investigate the clinical efficacy of oral anti-early pregnancy drugs combined with Qinggong in the treatment of missed abortion.Methods A total of 86 patients with missed abortion admitted to our hospital from January 2017 to September 2018 were selected as the subjects.The patients were randomly divided into the observation group (n=43)and the control group (n=43).Patients in the observation group were treated with oral Mifepristone and Misoprostol,and then combined with uterine curettage.Patients in the control group were treated with oral Estradiol Valerate and then treated with uterine curettage.The intraoperative cervical softening and dilatation effects,the time spent on surgery,the amount of bleeding,the incidence of induced abortion syndrome,the natural excretion rate of the embryo after administration,and the success rate of one-time cure were observed and compared between the two groups respectively.Results The total effective rate of cervical softening and dilatation in the observation group was higher than that in the control group,the operation time of the observation group was shorter than that of the control group,and the amount of bleeding of the observation group was less than that of the control group,the incidence of induced abortion syndrome of the observation group was lower than that of the control group,and the natural excretion rate of the embryo and the one-time success rate of uterine curettage in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Oral anti-early pregnancy drug such as Misoprostol and Misoprostol combined with uterine curettage is more effective in the treatment of missed abortion.Oral anti-pregnancy drugs can reduce the difficulty of uterine surgery.the success rate of one-time cure under this treatment method is high,which can reduce the time spent on surgery,reduce the amount of bleeding,and reduce the incidence of induced abortion syndrome.This treatment method is worthy of popularization and application in the clinic.
2019 Vol. 26 (8): 122-124 [Abstract] ( 71 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
125 Feasibility analysis of Pituitrin combined with Carprostol Tromethamine in the treatment of massive hemorrhage after placental abruption
C HEN Lin
Objective To explore the feasibility of Pituitrin combined with Carprostol Tromethamine in the treatment of massive hemorrhage after placental abruption.Methods A total of 60 patients with placental abruption who were admitted to our hospital from June 2015 to December 2017 were selected as the research objects.All patients were divided into the treatment group(n=30)and the control group(n=30)according to random number table method.The two groups of patients underwent cesarean section,and were treated with Carprostol Tromethamine after surgery.The experimental group added Pituitrin on this basis.The prognosis,bleeding volume in different time periods,hemostasis time,total amount of bleeding,adverse reactions after treatment,Apgar score and incidence of neonatal asphyxia were compared between the two groups.Results The rate of blood transfusion and hysterectomy in the treatment group was significantly lower than that in the control group(P＜0.05).The bleeding volume and total amount of bleeding at t1,t2,t3and t4in the treatment group were significantly lower than those in the control group,while the hemostasis time in the treatment group was significantly shorter than that in the control group (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups after treatment(P＞0.05).There was no significant difference in neonatal Apgar score and the incidence of neonatal asphyxia between the two groups after delivery(P＞0.05).Conclusion Pituitrin-assisted Carprostol Tromethamine has a good inhibitory effect on postoperative bleeding in patients with placental abruption,and can shorten the bleeding time and reduce the total amount of bleeding,and has no significant effect on fetal delivery,and the security is also relatively good.
2019 Vol. 26 (8): 125-127转140 [Abstract] ( 60 ) HTML (35 KB)  PDF  (0 KB)  ( 14 )
128 Clinical effect of 5%Sodium Bicarbonate Injection combined with Triamcinolone Acetonide and Econazole Cream and ultraviolet light and threedimensional microwave therapy treating otomycosis externa in the elderly
LI Zhe; ZHANG Yun; LI Qi-zhu; LIANG Da-shuai; MENG Da-wei; BAO Ji-min
Objective To investigate the clinical effect of Sodium Bicarbonate Injection combined with Triamcinolone Acetonide and Econazole Cream and ultraviolet light and three-dimensional microwave therapy treating otomycosis externa in the elderly.Methods A total of 90 elderly patients with external ear canal mycosis admitted to our hospital from January 2016 to August 2018 were selected.The fungus and secretions on the external auditory canal and tympanic membrane were cleaned under rigid otoendoscopy.The patients were divided into the observation group and control group using the randomized digital table method,and there were 45 patients in each group.The observation groupo was given the comprehensive treatment：Mixed solution of Sodium Bicarbonate Injection combined with Triamcinolone Acetonide and Econazole Cream was used for ear drops,Triamcinolone Acetonide and Econazole Cream applied to the skin of the external ear canal,ultraviolet light and three-dimensional microwave.In the control group,patients were treated with Triamcinolone Acetonide and Econazole Cream was applied to smear the corresponding site,3 times a day.The patients in both groups were reviewed every 3 days,and after 2 weeks of treatment,they were followed up for 3 months for efficacy analysis.Results The total effective rate of the observation group was 97.78%,which was significantly higher than that of the control group(62.22%),and the difference was statistically significant(P＜0.05).Following up for 3 months,the recurrence rate of the observation group was 4.55%,which was significantly lower than that of the control group (35.71%)(P＜0.05).Conclusion 5%Sodium Bicarbonate Injection combined with Triamcinolone Acetonide and Econazole Cream and ultraviolet light and three-dimensional microwave therapy treating otomycosis externa in the elderly has the advantages of thorough clearance of lesions,high curative effect and low recurrence rate,and is worth popularizing.
2019 Vol. 26 (8): 128-131 [Abstract] ( 67 ) HTML (41 KB)  PDF  (0 KB)  ( 11 )
132 Clinical effect of dental implant reparir and fixed denture reparir in the treatment of dentition defect
WANG Ying-xiang
Objective To investigate the clinical effect of dental implant reparir and fixed denture reparir in the treatment of dentition defect and the influence on the tooth related index of patients.Methods From May 2016 to May 2018,92 patients with dentition defect treated in our hospital were selected as the study objects.According to the patients′visit sequence,the patients were divided into reference group and experimental group,each group had 46 cases.The reference group was treated with fixed denture repair,while the patients in the experimental group were treated with dental implant reparir.The clinical effect between the two groups was compared,and the relative indexes of gingival index(GI),plaque index(PLI)and gingival sulcus bleeding index(SBI)and so on were evaluated,and the repair of oral function in patients was observed.Results The total effective rate of treatment in the experimental group was 91.30%,which was higher than that of the reference group(73.91%),and the difference was statistically significant(P＜0.05).The scores of GI,PLI and SBI in the experimental group after repair treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).The scores of retainer function,masticatory function,language function and aesthetic degree in the experimental group after repair treatment were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The effect of dental implant repair for dentition defect is better than that of fixed denture repair.It can restore the oral function of patients more effectively and has good aesthetics.It is helpful to maintain the periodontal health of patients.It is worthy of clinical promotion.
2019 Vol. 26 (8): 132-134 [Abstract] ( 63 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
135 Effect comparison of multiple root canal therapy and disposable root canal therapy treating tooth body and endodontic disease in children
ZHONG Jian-ping; PAN Feng; LIU Yan; ZHENG Wei ; OUYANG Nan-qi
Objective To compare the clinical effect of multiple root canal therapy and disposable root canal therapy treating tooth body and endodontic disease in children.Methods A total of 165 children with tooth body and endodontic disease treated in our hospital from November 2016 to November 2017 were selected and they were divided into the two groups according to different treatment methods.82 patients in the control group were treated with multiple root canal.83 patients in the observation group were treated with disposable root canal.The clinical efficacy and the incidence of complications between the two groups were compared.Results There was no significant difference in the total effective rate between the two groups(χ2=0.09,P＞0.05).The pain disappearance time in the observation group([2.01±0.30]d)was shorter than that in the control group([2.17±0.20]d),and the difference was statistically significant(t=3.91,P＜0.05).There was no significant difference in the total incidence of postoperative complications between the two groups(χ2=0.00,P＞0.05).Conclusion Disposable root canal therapy and multiple root canal therapy treating tooth body and endodontic disease can achieve ideal results in children with tooth body and endodontic disease,and the pain disappearance time after disposable root canal therapy is shorter.
2019 Vol. 26 (8): 135-137 [Abstract] ( 73 ) HTML (30 KB)  PDF  (0 KB)  ( 13 )
138 Application effect of soft shell technique in phacoemulsification of cataract
YANG Ling; QU Zheng-peng
Objective To investigate the application effect of soft shell technique in phacoemulsification of cataract.Methods All of 30 patients (30 eyes)who underwent phacoemulsification treated in Binhai Hospital of Yingkou Aier Ophthalmology from April to September 2018 were selected.Duo Visc viscoelastic agent soft shell technique was used to protect the corneal endothelium during the operation.The best visual acuity,naked visual acuity and corneal endothelial cell related indexes were compared before and after operation inpatients.Results The best visual acuity correction and naked eye vision improvement after operation were better than those before operation (P＜0.05).The coefficient of variation of cell area after operation was higher than that before operation,and the hexagonal cells were lower than that before operation,and the differences were statistically significant(P＜0.05).Conclusion Soft shell technique can effectively improve the best visual acuity and naked visual acuity of patients with cataract phacoemulsification,and it will not cause serious damage to corneal endothelium,which is worthy of clinical reference and implementation.
2019 Vol. 26 (8): 138-140 [Abstract] ( 64 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
141 Effect of prophylactic intravenous Changtuoning on intraoperative chills in patients with acute appendicitis
QIU Yong; LUO Zhi-yong; FU Yun-juan
Objective To investigate the effect of prophylactic intravenous Changtuoning on intraoperative chills in patients with acute appendicitis.Methods A total of 62 patients with acute appendicitis who underwent operation in our hospital from October 2015 to February 2017 were selected as research subjects.According to the time of admission,they were randomly divided into control group and observation group,31 cases in each group.Patients in the control group were anesthetized with intravenous Pethidine,and patients in the observation group were anesthetized with intravenous Penehyclidine Hydrochloride.The changes of vital signs like blood oxygen saturation(SpO2),mean arterial pressure (MAP),and heart rate (HR)before and after medication,the total incidence rate of chills and adverse reactions after medication were observed and compared between the two groups.Results There were no significant differences in SpO2,HR and MAP between the two groups before injection(P＞0.05).The SpO2at 5,10,15 and 20 min after injection of the drug in the control group was significantly lower than that before injection,and the differences were statistically significant(P＜0.05).The SpO2at 5,10,15 and 20 min after injection of the drug in the observation group was significantly higher than that in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in HR and MAP between the two groups at 5,10,15 and 20 min after injection(P＞0.05).The total incidence rate of chills in the observation group was 6.45%,which was significantly lower than that in the control group(22.58%),and the difference was statistically significant(P＜0.05).The total incidence rate of adverse reactions in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The intravenous injection of Penehyclidine Hydrochloride can prevent the occurrence of chills in patients with acute appendicitis,and has no effect on the temperature,HR and blood pressure of patients,which is worthy of clinical promotion.
2019 Vol. 26 (8): 141-143 [Abstract] ( 80 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
144 Influence of cervical lymphatic tuberculosis on muscle relaxation effect of Rocuronium Bromide
HAN Ya-kunl; LIU Min-qiang; YU De-hui; HU Shu-jun
Objective To investigate the influence of cervical lymphatic tuberculosis on the muscle relaxation effect of Rocuronium Bromide when administrated by body surface area.Methods Forty patients who underwent general anesthesia for neck mass resection in our hospital from May to October 2017 were selected as study objects and they were divided into tuberculosis group(group T)and non-tuberculosis group(group NT)according to the disease type,20 cases in each group.In the induction of general anesthesia,according to the body surface area,2 times of ED95 Rocuronium Bromide was administered.The tracheal intubation was performed when the ratio of the fourth muscle twitch to the first muscle twitch(T4/T1,TOFr)of the train-of-four(TOF)stimulation of the abductor pollicis muscle was reduced to 0%.The tracheal intubation conditions,onset time,clinical duration,recovery index and pharmacological time were recorded between the two groups.Results There were no significant differences in tracheal intubation conditions between the two groups(P＞0.05).There were no significant differences in onset time,recovery index and pharmacological time between the two groups (P＞0.05).The clinical duration of Rocuronium Bromide in group T was (24.0±4.6)min,which was significantly shorter than that in group NT of(28.0±3.6)min,and the difference was statistically significant(P＜0.05).Conclusion The clinical action duration of administration of Rocuronium Bromide in patients with cervical lymphatic tuberculosis by body surface area is shorter than that of non-tuberculosis patients,and the interval between additional medications during perioperative period should be appropriately shortened.
2019 Vol. 26 (8): 144-146 [Abstract] ( 62 ) HTML (35 KB)  PDF  (0 KB)  ( 13 )
147 Effect of Dizocine on inhaled tracheal intubation induced by Sevoflurane in elderly patients
WAN Lun
Objective To investigate the effect of Dizocine on inhaled tracheal intubation induced by Sevoflurane in elderly patients.Methods A total of 50 elderly patients who underwent general anesthesia selective surgery and Sevoflurane inhalation-induced tracheal intubation admitted to our hospital from January 2017 to September 2018 were selected as subjects.According to the random number table method,they were divided into the experimental group(25 cases)and the control group (25 cases).In the experimental group,0.2 mg/kg of Dizocine was injected intravenously before induction of anesthesia,and 10 ml of normal saline was given intravenously before induction of anesthesia in the control group.The demodynamic parameters(cardiac index [CI],central venous pressure [CVP]and oxygen saturation[SpO2]),stress indicators(heart rate[HR],systolic blood pressure[SBP],diastolic blood pressure[DBP],respiratory rate[RR])before injecting drugs(T1),10 min(T2)after injecting drugs,1 min(T3)before tracheal intubation,1 min(T4)after tracheal intubation,and 10 min after tracheal intubation(T5)and the incidence of adverse reactions were compared between the two groups.Results There were no significant differences in CI,CVP and SpO2at T1between the two groups(P＞0.05).The CI,CVP and SpO2in the two groups at T2,T3,T4and T5were lower than those at T1,and the differences were statistically significant(P＜0.05).There were no significant differences in CI and CVP at T2,T3,T4and T5between the two groups (P＞0.05).The SpO2in the experimental group at T2,T3,T4and T5was higher than that in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in HR,SBP,DBP and RR at T1between the two groups(P＞0.05).The HR,SBP,DBP and RR at T2,T3,T4and T5in the experimental group were lower than those at T1,and the differences were statistically significant(P＜0.05).The HR,SBP,DBP and RR at T3,T4and T5in the control group were lower than those at T1,and the differences were statistically significant(P＜0.05).There were no significant differences in HR,SBP,DBP and RR between T1and T2in the control group (P＞0.05).The HR,SBP,DBP and RR at T2,T3,T4and T5in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence rate of adverse reactions during the anesthesia of the experimental group was 4.00%,which was significantly lower than that of the control group(32.00%),and the difference was statistically significant(P＜0.05).Conclusion Dizocine for the inhaled tracheal inhalation induced by Sevoflurane can improve the SpO2of patients,and it has stable hemodynamic parameters,less stress response after intubation,with high drug safety.
2019 Vol. 26 (8): 147-150 [Abstract] ( 60 ) HTML (50 KB)  PDF  (0 KB)  ( 12 )
151 Clinical effect of Tanreqing Injection combined with Shenfu Injection in the treatment of senile severe pneumonia
GUO Yu-mei;GENG Li-li;SHU Jiao-jie; ZHANG Yun; XU Xian-nan; LIU Hao; ZANG Shi-guo
Objective To investigate the clinical effect of Tanreqing Injection combined with Shenfu Injection in the treatment of senile severe pneumonia.Methods All of 98 elderly patients with severe pneumonia treated in our hospital from June 2016 to June 2018 were selected as the study subjects.The patients were divided into the control group and observation group according to the random number table method,with 49 cases in each group.The patients in the control group were treated with routine western medicine such as anti-infection,phlegm-resolving,assisted ventilation and nutritional support.The observation group was treated with Tanreqing Injection and Shenfu Injection on the basis of the control group.The total effective rate of treatment,mortality rate,residence time in intensive care unit(ICU),hospitalization day and hospitalization cost,blood routine and blood gas analysis were compared between the two groups.Results The total effective rate in the observation group was higher than the control group,the mortality rate was lower than the control group,the residence time in ICU and the hospitalization day were shorter those of the control group,and the hospitalization cost was less than that in the control group,and the differences were significant(P＜0.05).After treatment,the white blood cell(WBC)in the two groups were lower than those before treatment,and the WBC in the observation group was lower than that of the control group,and the differences were statistically significant(P＜0.05).The platelet(PLT),arterial partial pressure of oxygen(PaO2),blood oxygen saturation(SaO2),oxygenation index(PaO2/FiO2)in the two groups were higher than those before treatment,and the above-mentioned indexes in the observation group was higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion On the basis of conventional western medicine treatment,the addition of Tanreqing Injection and Shenfu Injection can significantly improve the treatment effect of senile patients with severe pneumonia,reduce mortality rate and shorten the course of disease,which is worthy of clinical promotion.
2019 Vol. 26 (8): 151-154 [Abstract] ( 81 ) HTML (38 KB)  PDF  (0 KB)  ( 12 )
155 Effect of Buzhong Yiqi Decoction combined with pelvic floor electrical stimulation and biofeedback treating uterine prolapse with weakness of qi and blood
CHEN Chang-kai; ZONG Yi
Objective To explore the effect of Buzhong Yiqi Decoction combined with pelvic floor electrical stimulation and biofeedback treating uterine prolapse with weakness of qi and blood.Methods All of 132 patients with uterine prolapse with weakness of qi and blood admitted to our hospital from June 2016 to December 2017 were selected and they were divided into group A(n=66)and group B(n=66)according to the system randomization method.Group A was treated with Buzhong Yiqi Decoction,and group B was treated with Buzhong Yiqi Decoction combined with pelvic floor electrical stimulation and biofeedback.The clinical effect,the pelvic floor muscles function and the improvement of urinary incontinence before and after treatment between the two groups were compared.Results The total effective rate of group B(89.39%)was significantly higher than that of group B(72.73%),and the difference was statistically significant(P＜0.05).After treatment,the dynamic vaginal pressure and vaginal contraction EMG of the two groups were higher than those before treatment,and the duration of vaginal contraction was longer than that before treatment,and the above indexes of group B were significantly better than those of group A (P＜0.05).The improvement rate of urinary incontinence in group B(71.21%)was significantly higher than that in group A(48.48%)(P＜0.05).Conclusion Buzhong Yiqi Decoction combined with pelvic floor electrical stimulation and biofeedback have a good clinical effect on uterine prolapse with weakness of qi and blood,which can effectively improve the pelvic floor muscle function and improve urinary incontinence in patients.
2019 Vol. 26 (8): 155-157 [Abstract] ( 71 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
158 Clinical effect observation of autohemotherapy in the treatment of bronchial asthma during remission period
ZHENG Yuan-fang; LI Xia-mei; LI Fei-fei; HU Zhao-xia
Objective To investigate the clinical effect of autohemotherapy in the treatment of bronchial asthma at remittent period.Methods From May 2015 to May 2017,a total of 120 outpatient and inpatient patients with bronchial asthma during remission period treated in Department of Respiratory of the First Traditional Chinese Medicine Hospital in Changde City were selected and they were divided into the treatment group(n=60)and control group(n=60)according to the random number table method.Patients in the control group were treated with Salmeterol Roticasone Powder,while patients in the treatment group were treated with autohemotherapy via meridians.The efficacy and the asthma control test(ACT)score before and after treatment between the two groups were compared.Results There was no significant difference of the curative effect between the two groups (P＞0.05).There was no significant difference in ACT score between the two groups before treatment,after treatment and follow-up for 1 month (P＞0.05).The ACT score of the two groups after treatment was higher than that before treatment,and the difference was statistically significant(P＜0.05).Follow-up for 1 month showed that ACT scores of the two groups were significantly higher than those before and after treatment,with statistical differences (P＜0.05).Conclusion Both autohemotherapy and Salmeterol Roticasone Powder have curative effect in the treatment of asthma during remission period.There is no significant difference in the efficacy treated by autohemotherapy and Salmeterol Roticasone Powder therapy.
2019 Vol. 26 (8): 158-161 [Abstract] ( 64 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
162 Clinical effect of modified Phragmites Stem Decoction of TCM plusing bronchoalveolar lavage with fiberoptic bronchoscope treating acute exacerbation of bronchiectasis complicated with infection in the elderly
HE Yuan-feng
Objective To discuss the clinical effect of modified Phragmites Stem Decoction of TCM plusing bronchoalveolar lavage with fiberoptic bronchoscope treating acute exacerbation of bronchiectasis(BE)complicated with infection in the elderly.Methods All of 62 elderly patients with acute exacerbation of bronchiectasis complicated with infection treated in our hospital from March 2017 to April 2018 were selected as objects and they were grouped according to the order of admission,and there were 31 cases in each group.The control group was treated with the bronchoalveolar lavage with fiberoptic bronchoscope,while the observation group was treated with modified Phragmites Stem Decoction of TCM plusing bronchoalveolar lavage with fiberoptic bronchoscope.The blood gas analysis indicators changes were observed,symptom improvement time was compared and therapeutic effect were evaluated between the two groups.Results Before treatment,the partial pressure of oxygen(PaO2),oxygen saturation(SaO2)and PaO2/fraction of inspiration oxygen(PaO2/FiO2)showed no statistical differences between the two groups(P＞0.05).After treatment,the values of PaO2,SaO2and PaO2/FiO2in the observation group were higher than those of the control group,with statistical differences(P＜0.05).The symptom improvement time of pulmonary infection,fever,cough,expectoration and moist rale in the observation group were shorter than those of the control group,with statistical differences(P＜0.05).The total effective rate in the observation group(93.55%)was higher than that of the control group(77.42%),with statistical difference (P＜0.05).Conclusion The modified Phragmites Stem Decoction of TCM plusing bronchoalveolar lavage with fiberoptic bronchoscope can efficiently improve the arterial blood analysis indicators,and it takes shorter time to control infection and improve clinical symptoms,with higher treatment effective rate and faster recovery of patients.
2019 Vol. 26 (8): 162-164 [Abstract] ( 69 ) HTML (36 KB)  PDF  (0 KB)  ( 13 )
165 Investigation on the knowledge of classified diagnosis and treatment system in urban and rural residents in western Hu′nan
HUANG Dong； LI Ji-hong； ZHAO Le-le； ZHAO Si-jun； ZHANG Xin ；ZHANG Yan-li；ZHANG Lu-fen
Objective To understand the knowledge and influencing factors of classified diagnosis and treatment system in urban and rural residents in western Hu′nan,and to provide reference for the development and improvement of classified diagnosis and treatment system.Methods From January to July 2018,1265 residents were randomly selected in western Hu′nan for face-to-face interview with self-made closed questionnaire,and 1208 valid questionnaires were collected.The data were recorded by Excel 2003 and analyzed with charts.Results The awareness rate of urban residents was 47.0%and that of township residents was 21.7%.Urban residents understood the classified diagnosis and treatment system mainly through the promotion of community health service organizations (35.1%),and township residents understood the classified diagnosis and treatment system mainly through the introduction of doctors(41.6%).Residents believed that the lack of service capacity of primary hospitals was the main factor affecting the development of classified diagnosis and treatment system.Conclusion The awareness rate of the classified diagnosis and treatment system in urban and rural residents in western Hu′nan needs to be improved,and the gap of the awareness rate between urban and rural residents is wide.The ways for urban and rural residents to understand the classified diagnosis and treatment system are different.The relevant institutions at all levels should increase their publicity efforts to promote residents to understand the classified diagnosis and treatment system,reduce the gap between urban and rural residents,and promote the effective implementation of the system.
2019 Vol. 26 (8): 165-167转171 [Abstract] ( 60 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
168 Research on improving the quality of work by analyzing the causes of low-risk death cases in a hospital
WANG Ping； LIU Zong-lan； CHEN Xu-hui； LIU Li； YAO Xing-feng
Objective To analyze the problems existing in low-risk death cases and find out ways to improve work quality.Methods After the first page of the medical records of patients discharged from a hospital in 2015 was processed by the DRGs grouper,the reasons for the grouping of low-risk deaths in 2015 were analyzed,the causes were identified and the improvement measures were taken for these problems in 2017.Results By strengthening medical record management and medical quality management,the hospital total number of deaths decreased from 528 to 504,and the total death proportion in the hospital decreased from 0.739%to 0.616%.The number of low-risk deaths decreased from 8 to 3,and the proportion of low-risk deaths in the hospital dropped from 0.011%to 0.004%.Conclusion By analyzing the cases of low-risk deaths,the problems of medical record management and medical quality management can be found out quickly and effectively,and the improvement measures can be implemented timely,so as to improve the quality of hospital medical record management and medical management.
2019 Vol. 26 (8): 168-171 [Abstract] ( 71 ) HTML (30 KB)  PDF  (0 KB)  ( 15 )
172 Analysis of self-management status and its influencing factors of patients after first-time percutaneous coronary intervention
WANG Li-na； XIE Xian-ping； MA Yan
Objective To understand the status of self-management behavior of patients after first-time percutaneous coronary intervention (PCI),and to analyze the influencing factors,so as to provide a scientific basis for improving the self-management behavior of patients after the first-time PCI.Methods A convenient sampling method was used to select 160 patients who underwent the PCI for the first time from November 2017 to March 2018 admitted to the department of cardiovascular medicine of a tertiary hospital in Shanxi province.The general data questionnaire and the self-management behavior scale for coronary heart disease were used to investigate the patients.Results The total score of self-management ability of patients was(70.97±13.99)points,and the scoring rate was 52.57%,which was at the middle-lower level.There were statistically significant differences in the scores of self-management behaviors among patients with different ages,education,income,occupation,smoking,alcohol consumption and complicated with hypertension and diabetes(P＜0.05).Multiple linear regression analysis showed that age,education,smoking and income levels were independent risk factors for self-management of patients underwent the PCI for the first time(P＜0.05).Conclusion After the first-time PCI operation,the self-management behaviors of the patients are below medium level and affected by many factors.
2019 Vol. 26 (8): 172-176 [Abstract] ( 79 ) HTML (42 KB)  PDF  (0 KB)  ( 16 )
177 Application effect of participatory training applied in training new nurses in ICU
DING Xin-bo； DENG Lan； HU Fen； TAO Jing-chuan
Objective To explore the effect of participatory training applied in training new nurses in ICU.Methods A total of 62 new nurses in ICU in June 2017 were assigned as the research object.According to the random digital table method,they were grouped into the experimental group (n=31)and the control group (n=31)to receive 32 separate hours of training.The experimental group took part in the participatory training which combined theory with practice by specific cases,while the control group were trained by the traditional approach.The standard of unified nursing quality control in Hubei Province and the questionnaire of inpatients′satisfaction with nursing service were used to compare the theoretical knowledge of medical care,nursing quality control and patients′satisfaction between the two groups of new nurses.Results The average scores of theoretical knowledge,quality control,and the satisfaction degree in participatory training group were higher than those of the traditional teaching group,the differences were statistically significant(P＜0.05).Conclusion Participatory training can improve the theoretical knowledge of medical care,nursing quality control and patients′satisfaction,and optimize the training of new nurses.
2019 Vol. 26 (8): 177-179 [Abstract] ( 71 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
180 Application effect of detail management in nursing cooperation management between the departmen of hospital-acquired infection control and supply room
LIU Jian-hua； CHEN Xing-mei； LI Ying-qiang
Objective To explore the application effect of detail management in nursing cooperation management between the departmen of hospital-acquired infection control and supply room.Methods From January 2017 to January 2018,the quality improvement team was established by combining departmen of hospital-acquired infection control and supply room in our hospital.Detailed analysis of the two departments in the management of the existing problems,and to develop detailed management measures to improve the quality of management.The quality of nursing before and after quality improvement were compared with the satisfaction of each department.Results After the implementation of detail management,the scores of risk awareness,service awareness and safety problem identification ability of supply room staff were higher than those before the implementation of detail management,and the differences were statistically significant(P＜0.05).Moreover,the qualified rate of disinfection monitoring and the satisfaction of clinical departments to the supply room were higher than those before the implementation of detail management,the incidence of risk events was lower than that before the implementation,the differences were statistically significant(P＜0.05).Conclusion The application of detail management in the cooperative nursing management between the departmen of hospital-acquired infection control and supply room can significantly standardize the management of the supply room of the hospital and prolong the service life of the equipment.It is an important basis to ensure the working effeciency and quality of the supply room.
2019 Vol. 26 (8): 180-182 [Abstract] ( 76 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
183 Application effect of hierarchical management method in operation room nursing management
XU Gui-hua； XIONG Shu-ling； GONG Hua-cheng3
Objective to explore the application effect of hierarchical management method in operating room nursing management.Methods A total of 56 patients with routine operating room nursing management in our hospital from September 2016 to January 2017 were selected as the control group,and 56 patients with hierarchical operating room management from June 2017 to January 2018 were selected as the observation group.The nursing effects of the two groups were compared.Results The total nursing satisfaction and scores of nursing quality in the observation group were significantly higher than those in the control group,the differences were statistically significant(P＜0.05).The times required for collection and supplementation in the observation group were significantly shorter than those in the control group,and the detection index of air bacteria was significantly lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion The application of hierarchical management method in operating room nursing management is significant and worth popularizing.
2019 Vol. 26 (8): 183-185转201 [Abstract] ( 71 ) HTML (35 KB)  PDF  (0 KB)  ( 10 )
186 Effect of protective motivation nursing on quality of life and self-care ability of elderly patients with coronary heart disease
JIANG Yun-fei； HU Cheng-jie▲
Objective To explore the effect of protective motivation nursing on quality of life and self-care ability of elderly patients with coronary heart disease (CHD).Methods Sixty elderly patients with CHD admitted to our hospital from May 2016 to March 2018 were selected.According to different nursing methods,they were divided into observation group(n=30)and control group(n=30).The control group was given basic nursing,and the observation group was given protective motivation nursing.Results The scores of self-nursing ability scale (ESCA),including health knowledge([27.24±3.16]points),nursing skills([37.53±4.36]points),self-concept([28.24±3.56]points)and self-care responsibility ([28.63±5.23]points)in the observation group were significantly higher than those in the control group (P＜0.05）.The seattle angina questionnaire(SAQ)scores of the observation group included disease cognition degree([86.03±8.35]points),treatment satisfaction degree ([83.25±6.81]points),angina pectoris attack ([82.21±7.91]points),stable angina pectoris([84.53±6.93]points),and physical restriction degree ([80.56±6.17]points)were significantly higher than that of the control group (P＜0.05）.Conclusion Protective motivation nursing can improve the self-care ability of elderly patients with CHD,improve the quality of life of patients,worthy of promotion.
2019 Vol. 26 (8): 186-188 [Abstract] ( 80 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
189 Application effect of TCM syndrome differentiation nursing in diabetic foot ulcer
LUO Bing； LIU Qing
objective To investigate the effect of TCM syndrome differentiation nursing on treating diabetic foot ulcer with negative pressure closed drainage.Methods A total of 72 patients with diabetic foot ulcer treated in TCM Hospital of Zhaoqing City from October 2016 to March 2018 were selected and divided into the observation group and the control group according to the random number table,36 cases in each group.The observation group was given TCM syndrome differentiation and nursing,while the control group was given routine nursing measures,and negative pressure closed drainage was applied in both groups,the degree of pain relief and ulcer healing were compared between the two groups in one month after treatment.Results The pain relief degree of the observation group and the quality of ulcer healing were better than those of the control group,the total effective rate of the observation group was 97.22%,higher than the 66.44%of the control group,and the differences were statistically significant(P＜0.05）.Conclusion The TCM syndrome differentiation nursing has a good effect in the treatment of diabetic foot ulcer with negative pressure closed drainage,and quickly relieve pain symptoms and reduce the area of ulcer.
2019 Vol. 26 (8): 189-191 [Abstract] ( 66 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
192 Effect of minimal feeding nursing on the balance of intestinal flora in premature infants
CAO Chun-ying ； WANG Li-zhu ；YI Mei-hong ； ZHONG Xiu-hua ； SHEN Ming-li
Objective To observe the effect of minimal feeding nursing on the balance of intestinal flora in premature infants.Methods A total of 120 premature infants admitted to our hospital from June 2017 to June 2018 were selected as subjects and randomly divided into study group and control group,60 cases in each group.Preterm infants in the study group were given early minimal feeding,and preterm infants in the control group were given routine feeding.Real-time quantitative PCR was used to determine the number of intestinal bacteria in both groups.The changes of intestinal flora in the premature infants of the two groups were observed.Results After feeding,the number of bacillus,cocci and total bacteria increased in both groups,but the study group increased more significantly than the control group,the difference was statistically significant(P＜0.05）.Conclusion Minimal feeding nursing has a positive impact on the establishment of intestinal flora balance in premature infants.
2019 Vol. 26 (8): 192-194 [Abstract] ( 72 ) HTML (30 KB)  PDF  (0 KB)  ( 11 )
195 Application effect of perioperative comprehensive nursing in patients with lower limb skin and soft tissue defects
YE Hui-ping ； CHEN Min-ting； WANG Ying-qiong
Objective To investigate the application effect of perioperative comprehensive nursing in patients with lower limb skin and soft tissue defects treated by skin stretching device.Methods Sixty patients with skin and soft tissue defects of the lower limbs from May 2013 to May 2018 in our hospital were selected.The patients were divided into observation group and control group according to the operation time of skin stretcher,30 cases in each group.The observation group was given perioperative comprehensive nursing and the control group was given routine nursing intervention.The effects were evaluated by comparing the indicators such as postoperative wound area and others.Results The average wound area of the two groups was gradually reduced after intervention,but the area on the 3thand 5thdays after operation in observation group was lower than that in the control group,the difference was statistically significant(P＜0.05）.The duration of stretch in observation group was significantly shorter than the control group,the difference was statistically significant(P＜0.01）.The postoperative wound infection rate of the observation group and the control group was respectively 3%and 27%,the difference was statistically significant(P＜0.05）.The overall satisfaction of the observation group was higher than the control group,the difference was statistically significant(P＜0.05）.Conclusion Perioperative comprehensive nursing is effective in the treatment of skin soft tissue defects in lower limbs with skin stretching device.It is worth to be promoted.
2019 Vol. 26 (8): 195-197 [Abstract] ( 71 ) HTML (35 KB)  PDF  (0 KB)  ( 10 )
198 Effect of quality control circle on reducing the incidence of hypoglycemia in hospitalized patients with type 2 diabetes
YU Hong-hua
Objective To explore the effect of quality control circle (QCC)on reducing the incidence of hypoglycemia in hospitalized patients with type 2 diabetes (T2DM).Methods A total of 47 patients with T2DM in our hospital from July 2017 to December 2017 were selected as the control group (n=47).47 patients with T2DM in our hospital from January 2018 to June 2018 were randomly selected as the study group (n=47).The control group was given routine care,and the study group was given QCC on the basis of the control group.The compliance behaviors of the two groups(standardized medication,active exercise,reasonable diet,and self-glycemia monitoring)and the incidence of hypoglycemia,satisfaction with nursing work,and quality of life (SF-36)before and after intervention scores were counted.Results The study group′s standardized drug use rate (97.87%),positive exercise rate (89.36%),reasonable diet rate(89.36%),and self-glycemia monitoring rate (95.74%)were higher than those in the control group (72.34%,65.96%,68.09%,and 70.21%),the incidence of hypoglycemia (8.51%)was lower than that of the control group (25.53%),the differences were statistically significant(P＜0.05).The total satisfaction of nursing work in the study group(93.62%)was higher than that of the control group (76.60%),and the difference was statistically significant(P＜0.05）.The scores of SF-36 after intervention were higher than those before intervention in both groups,and that of the study group was higher than that of the control group,and the differences were statistically significant(P＜0.05）.Conclusion QCC can effectively improve the compliance behavior of patients with T2DM,reduce the incidence of hypoglycemia,and improve the quality of life of patients and improve the satisfaction of nursing work.
2019 Vol. 26 (8): 198-201 [Abstract] ( 66 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
202 Effect of nursing mode of traditional Chinese medicine on prevention of lower limb venous thrombos in patients with femoral neck fracture after operation
FU Shao-yan； XIONG Zhen； LI Xuan
Objective To evaluate the effect of traditional Chinese medicine(TCM)nursing mode on prevention of lower limb venous thrombosis in patients with femoral neck fracture after operation.Methods Sixty-two elderly patients with femoral neck fracture treated in our hospital from February 2017 to May 2018 were selected and divided into observation group(n=31)and control group(n=31)according to the time of treatment.The observation group was adopted traditional Chinese medicine nursing mode,while the control group was adopted conventional nursing mode.The clinical related indexes(pain score 7 day after operation,lower limb swelling degree),nursing satisfaction and incidence of lower limb venous thrombosis)were compared between the two groups.Results The pain score,lower extremity swelling degree and lower extremity venous thrombosis incidence in the observation group were lower than those in the control group 7 days after operation,and the differences were statistically significant(P＜0.05）.The total nursing satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05）.Conclusion TCM nursing after operation of femoral neck fracture can prevent venous thrombosis of lower extremity and play a strong role in improving swelling degree and pain symptoms of lower extremity.
2019 Vol. 26 (8): 202-204 [Abstract] ( 61 ) HTML (29 KB)  PDF  (0 KB)  ( 12 )
205 Effect of comprehensive physical and mental nursing intervention in the treatment of patients with chronic hepatitis B
ZHANG Jue
Objective To explore the effect of comprehensive physical and mental nursing intervention in the treatment of chronic hepatitis B patients and the influence of anxiety and depression on patients.Methods From March 2016 to March 2018,94 patients with chronic hepatitis B in our hospital were selected and divided into routine nursing group(n=47)and comprehensive nursing group(n=47)according to random number table method.The patients in both groups were treated with routine antiviral therapy and liver protection therapy.The patients in routine nursing group were given routine nursing and the patients in comprehensive nursing group were given comprehensive nursing of body and mind.After 6 months of treatment and nursing,the compliance,recovery,anxiety and depression were compared between the two groups.Results The total compliance rate in the comprehensive nursing group were significantly higher than those in the routine nursing group(P＜0.05）.The recovery rate of liver function,the recovery rate of α-fetoprotein and the negative conversion rate of hepatitis B virus deoxyribonucleic acid in the comprehensive nursing group were significantly higher than those in the routine nursing group (P＜0.05）.There was no significant difference in self-rating anxiety scale scores and self-rating depressive scale scores before nursing between the two groups (P＞0.05）,but the SAS and SDS scores were significantly decreased in the two groups after nursing(P＜0.05）.The SAS and SDS scores in comprehensive nursing group were significantly lower than those in routine nursing group(P＜0.05）.Conclusion Physical and mental comprehensive nursing intervention in the treatment of patients with chronic hepatitis B can improve the compliance of the patients,so that the patients can recover,but also can effectively alleviate the anxiety and depression of patients and other adverse emotions.
2019 Vol. 26 (8): 205-207转210 [Abstract] ( 73 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
208 Application effect of Erythromycin Ointment in blunt needle eyebatton puncturing of arteriovenous fistula
LI Ni-hong
Objective To study the effect of Erythromycin Ointment in the puncture of the blunt needle of intemal arteriovenous fistula.Methods A total of 46 patients with intemal arteriovenous fistula treated in our hospital from September 2017 to February 2018 were selected as the subjects.The patients were divided into control group (23 cases)and observation group (23 cases)according to random number table method.The control group was treated with routine post-puncture treatment,while the observation group was treated with erythromycin ointment at the puncture site.The complications and the incidence of infection after treatment between two groups were compared between the two groups.Results Patients in the observation group complication rate was 17.39%,which was lower than that of the control group(34.78%),the difference was statistically significant(P＜0.05）.The infection rate of the observation group was 13.04%,which was lower than that of the control group(21.74%).The difference was statistically significant(P＜0.05）.Conclusion The application of erythromycin ointment in blunt needle buttonhole puncture of intemal arteriovenous fistula is simple,convenient,safe,effective and cheap.It can easily remove the scab of the wound while preventing the infection of internal fistula.It is worth popularizing in clinic.
2019 Vol. 26 (8): 208-210 [Abstract] ( 59 ) HTML (28 KB)  PDF  (0 KB)  ( 11 )
211 Application effect of nursing intervention in vesicovaginal fistula after extensive hysterectomy for cervical cancer
ZHONG Jing-hua
Objective To analyze the nursing effect of vesicovaginal fistula after extensive hysterectomy for cervical cancer.Methods A total of 103 patients with cervical cancer admitted to our hospital from January 2015 to June 2018 were selected and divided into observation group (n=53)and control group (n=50)according to random number table method.Patients in the control group were treated with routine nursing intervention,while in the observation group,participants were treated with targeted nursing intervention.The incidence of vesicovaginal fistula,quality of life and satisfaction in the two groups were analyzed.Results The incidence of vesicovaginal fistula in the observation group was lower than that in the control group,with significant difference (P＜0.05）.At the same time,the quality of life scores including psychological function,physical fitness and activity of daily living in the observation group were higher than those of the control group,with statistical significance (P＜0.05）.The total nursing satisfaction of patients in the observation group was higher than that in the control group,with statistical difference (P＜0.05）.Conclusion For patients with extensive cervical resection due to cervical cancer can reduce the incidence of vesicovaginal fistula,improve the quality of life,ensure their health,and increase their satisfaction,which is worthy of clinical promotion.
2019 Vol. 26 (8): 211-213 [Abstract] ( 70 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
214 Nursing intervention in promoting functional recovery and reducing pain of patients with deep burn
LIANG Yan; ZHONG Bing-bing
Objective To explore the role of nursing intervention in postoperative functional recovery and reducing the degree of pain in patients with deep burn.Methods A total of 46 patients with deep burn in our hospital from January 2013 to July 2017 were selected and divided into the observation group and the control group according to the random number table method,23 cases in each group.The patients in the control group were given burn nursing routine,and the patients in the observation group were given nursing intervention on the basis of the routine burn care.The postoperative functional recovery rate,pain degree,infection rate and wound healing were compared between the two groups.Results The postoperative functional recovery rate in the observation group was 100.00%,which was higher than 73.91%of the control group,the difference was statistically significant(P＜0.05）.Before nursing intervention,the two groups had no statistically significant difference between patients with VAS score(P＞0.05）.The VAS scores of two groups after nursing were significantly lower than before nursing,the differences were statistically significant(P＜0.05）.The VAS score of the observation group after nursing was significantly lower than that of the control group,the difference was statistically significant(P＜0.05）.The wound healing time in the observation group was significantly shorter than that in the control group,and the difference was statistically significant(P＜0.05）.Conclusion Nursing intervention for patients with deep burn can improve postoperative functional recovery of patients,reduce pain degree and accelerate the healing time of wounds and infection rate,which is worthy of promotion in clinical practice.
2019 Vol. 26 (8): 214-216 [Abstract] ( 67 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
217 Effect of comprehensive nursing intervention on postoperative comfort degree of children with limbs fracture
ZENG Jie; HE Xiao-fang; LIN Li; ZENG Fan-ying ; KANG Lu-hua
Objective To observe the effect of comprehensive nursing intervention on the postoperative comfort of degree children with limbs fracture.Methods A total of 62 cases of orthopedic surgery were collected from January 2015 to January 2017 in our hospital and divided into observation group and control group according to the random number table method,31 cases in each group.The control group was used routine nursing,and the observation group was used comprehensive nursing intervention,the postoperative anxiety degree,pain improvement degree and nursing satisfaction of two groups were compared.Results The anxiety score of the observation group was (37.62±4.21)point,which was lower than that of the control group(45.36±4.62)point,the difference was statistically significant(P＜0.05）.The observation group pain score was lower than the control group,the difference was statistically significant(P＜0.05）.The nursing satisfaction of the observation group was 96.77%,which was higher than the control group of 67.74%,the difference was statistically significant(P＜0.05）.Conclusion The application of comprehensive nursing intervention in the postoperative nursing of children with limbs fracture has remarkable effect and has the value of clinical use.
2019 Vol. 26 (8): 217-219 [Abstract] ( 58 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
220 Effect of psychological nursing intervention on negative emotions and compliance of young and middle-aged patients with ischemic stroke
SHAO Min; WANG En-ming;
Objective To analysis the effect of psychological nursing intervention on negative emotions and compliance of young and middle-aged patients with ischemic stroke.Methods A total of 95 young and middle-aged patients with ischemic stroke in our hospital from December 2016 to December 2017 were selected and divided into control group(n=47)and study group (n=48)according to the random number table method.The control group was received routine nursing intervention,and the study group combined psychological nursing intervention.The intervention period was 3 months.The negative emotions were evaluated by self rating anxiety scale(SAS)and self rating depression scale(SDS),and the negative emotion and treatment compliance were compared between the two groups before and after intervention.Results There was no significant difference in the SAS and SDS scores between the two groups before intervention(P＞0.05）.After intervention,the scores of SAS and SDS of the two groups decreased,and the scores of the study group were lower than those of the control group,the differences were statistically significant(P＜0.05）.The compliance rate of the study group was 93.75%,which was significantly higher than that of the control group (76.60%),the difference was statistically significant(P＜0.05）.Conclusion Psychological nursing intervention can significantly relieve the negative emotions of young and middle-aged patients with ischemic stroke and improve their treatment compliance,which is of high clinical value.
2019 Vol. 26 (8): 220-222 [Abstract] ( 79 ) HTML (30 KB)  PDF  (0 KB)  ( 18 )
223 Application effect of multi-directional nursing intervention on the nursing of patients with compulsory schizophrenia
TAN Feng-ling; CUI Qian; XIE Ji-qun
Objective To investigate the effect of multi-directional nursing intervention on the nursing of patients with compulsory schizophrenia.Methods Eighty patients with schizophrenia who were hospitalized in our ward from March 2017 to March 2018 were selected.(Patients were identified as schizophrenia without criminal capacity by the judicial authorities after the accident,and they were forced to be hospitalized).According to the random number table method was divided into control group and observation group，each group has 40 cases.The control group was received the conventional nursing.and the observation group were given multi-directional nursing intervention on the basis of conventional nursing.The anxiety self-assessment table (SAS)，The Mental Disorder Scale(BPRS)and the world Health Organization Quality of life Measurement scale summary(WHOQOL-BREF)score before and after nursing were compared between the two groups.Results There were no significant differences in SAS,BPRS,WHOQOL-BREF scores between the two groups before interuention(P＞0.05）.After the intervention,the BPRS score([135.20±29.47]points)and SAS score [40.42±7.24]points)in the observation group were significantly lower than those in the control group (P＜0.05）.The WHOQOL-BREF score ([58.15±8.37]points)in the observation group was significantly higher than that in the control group(P=0.000）.Conclusion Multi-directional nursing intervention can significantly improve the condition of patients with schizophrenia,alleviate their anxiety and improve their quality of life.
2019 Vol. 26 (8): 223-225 [Abstract] ( 65 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
226 Application of limb restraint band in chest X-ray examination of children
CHEN Yun-hua; YANG Mu-lan; WU Hai-sheng; XUE Jian-feng
Objective To explore an alternative method of postural restraint in children′s chest X-ray examination to avoid X-ray exposure of family members.Methods A total of 681 children aged 1-3 who underwent chest radiography from July 2017 to June 2018 in our hospital were selected in this study.All of them were grouped by the parity of X-ray examination numbers,odd numbers as the control group (340 cases)and even numbers as the experimental group(341 cases).In the control group,one family member fixed the upper limb and the other fixed the lower limb.In the experimental group,the modified limb restraint band was used to fix the limbs.The quality of chest radiograph,Incidence of bedfall in children and the number of family members were compared between the two groups.Results Compared the two groups,there was no statistically significant difference in image quality and Incidence of bedfall in children(P＞0.05）.The rate of accompanying examination of family members in the experimental group(34.60%)was significantly lower than that in the control group(160.90%),the difference was statistical significance(P＜0.05）.Conclusion The limb restraint band produced by this study can effectively fix the limbs of children and avoid or reduce X-ray exposure of family members.
2019 Vol. 26 (8): 226-228 [Abstract] ( 81 ) HTML (30 KB)  PDF  (0 KB)  ( 6 )
232 Application effect of evidence-based nursing in the nursing of patients with severe acute pancreatitis
XIE Dan
Objective To explore the application effect of evidence-based nursing in the nursing of patients with severe acute pancreatitis （SAP）,to provide theoretical basis for nursing quality management of patients with severe acute pancreatitis.Methods From January 2014 to December 2016,60 patients with SAP in our hospital were selected as the research objects.All patients were randomly divided into observation group and control group,30 cases in each group.In the control group patients were given routine nursing,and in the observation group patients were given evidencebased nursing.The complications,hospitalization time,nursing effect and nursing satisfaction of the two groups were compared.Results The incidence of complications in the observation group (6.7%)was lower than that in the control group (23.3%),the difference was statistically significant(P＜0.05）.The hospitalization time in the observation group([5.7±1.2]days)was shorter than that in the control group ([10.4±1.5]days),the difference was statistically significant(P＜0.05）.The rate of nursing excellence and total satisfaction in the observation group were 96.7%and 93.3%,higher than that in the control group (80.0%and 73.3%),the differences were statistically significant(P＜0.05）.Conclusion Evidence-based nursing can reduce complications,shorten treatment time,improve the nursing effect and the nursing satisfaction in the nursing of patients with SAP,and worthy of clinical application.
2019 Vol. 26 (8): 232-234 [Abstract] ( 64 ) HTML (30 KB)  PDF  (0 KB)  ( 13 )
235 Effect of high quality nursing care on postpartum hemorrhage of pregnant women with hypertensive syndrome complicating pregnancy
WEI Hai-rong

Objective To explore the effect of high quality nursing in postpartum hemorrhage of pregnant women with hypertensive syndrome complicating pregnancy.Methods From January 2014 to January 2017,100 pregnant women with postpartum hemorrhage complicating hypertension syndrome during pregnancy in our hospital were selected and divided into control group and observation group according to random number table method,50 cases in each group.The control group was treated with routine nursing,the observation group was treated with high quality nursing.The amount of postpartum bleeding,postpartum hemostasis time,sleep time and nursing satisfaction were compared between the two groups.Results Delivery in observation group The amount of bleeding at 2,24 hours after gynaecology of delivery in observation group was significantly lower than that in the control group(P＜0.05）.The hemostasis time of the observation group was significantly shorter than that of the control group,the sleep time was significantly longer than that of the control group,the PSQI score was lower than that of the control group,and the final nursing satisfaction was much higher than that of the control group,the differences were statistically significant(P＜0.05）.Conclusion The high quality nursing is helpful to stop bleeding,reduce the amount of bleeding,improve the sleep quality of the pregnant women with hypertension syndrome complicating pregnancy,and can greatly improve the satisfaction of the patients with nursing.
2019 Vol. 26 (8): 235-237 [Abstract] ( 82 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
238 Application effect of comprehensive nursing intervention in patients with hip replacement
CHENG Hui; XU Lin; LUO Xiu-qun
Objective To analyze the effect of comprehensive nursing intervention in improving the psychological state of patients with hip replacement surgery and reducing postoperative complications.Methods A total of 120 cases of hip replacement in department of orthopedics were systematically reviewed from January 2017 to February 2018 in our hospital.According to different nursing methods,all of the patients were divided into two groups,the experimental group and the control group.Each group had 60 patients.The control group was given routine nursing and the experimental group was given comprehensive nursing intervention.One month later,the anxiety,depression and the hip function before and after the nursing intervention were compared and the overall incidence of complications was counted.Results After the intervention，the self-rating depression scale (SDS)and self-rating anxiety scale (SAS)scores of all patients decreased，and the hip function scores increased,after the intervention,the SDS and SAS of the experimental group were significantly lower than those of the control group,and the hip function score of the experimental group was significantly higher than that of the control group,the total incidence of surgical complications in the experimental group was lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion Comprehensive nursing intervention can significantly improve the psychological state of patients with hip replacement surgery and effectively reduce the incidence of postoperative complications.The clinical effect is significant.It is worthy of clinical promotion.
2019 Vol. 26 (8): 238-240 [Abstract] ( 60 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
241 Application effect of early nursing on pregnant women with eclampsia and thrombosis tendency
XU Hui-zhen; HUANG Yong; LIN Hui-mei
Objective To explore the application effect of early nursing on pregnant women with eclampsia and thrombosis tendency.Methods A total of 68 pregnant women with thrombophilia who admitted to our hospital from January 2015 to December 2017 were enrolled in this study.The patients were divided into two groups,34 patients each group.In control group,routine nursing was used,while in observation group,early nursing intervention was adopted.The coagulation index,thrombus marker,platelet activation index and complication rate of the two groups were compared and analyzed.Results Participants were all delivered successfully without maternal and child death.After nursing,the prothrombin time(PT)and activated partial thromboplastin time(APTT)of the observation group were significantly longer compared with those in the control group.The fibrinogen (FBG)level of the observation group was significantly lower than that of the control group with statistical significance(P＜0.05).There was no significant difference in thrombin time(TT)between the two groups(P＞0.05).After nursing,the plasminogen activity(PLG)and antithrombin activity(AT)of the observation group were both significantly higher than those of the control group with significant differences (P＜0.05).The D-dimer(D-D)level of the observation group was much lower than that of the control group,with significant difference(P＜0.05).After nursing,lysosomal membrane glycoprotein(CD63)and platelet alpha granule membrane glycoprotein (CD62p)were significantly lower in the observation group than that in the control group (P＜0.05).The total incidence of postpartum complications in the observation group was significantly lower than that in the control group(P＜0.05).Conclusion Early care for pregnant women with eclampsia and thrombosis tendency can optimize the patient′s coagulation indexes,thrombus markers and platelet activation indexes in a low incidence of postpartum complications,which is worthy of further clinical application.
2019 Vol. 26 (8): 241-243 [Abstract] ( 108 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
244 Application effect of perioperative comprehensive nursing in patients with soft tissue defect of four limbs repaired by perforator flap transplantation
XIAO Xia; YANG Qian-qi; LIAO Qiong
Objective To analyze the application value of perioperative comprehensive nursing in the treatment of limb soft tissue defects with perforator flap transplantation.Methods Eighty-four patients with percutaneous soft tissue defects who underwent perforator flap transplantation in our hospital from May 2016 to May 2017 were enrolled.According to the order to visiting doctors,they were divided into the observation group(n=42)and the control group(n=42).In the control group,routine nursing was used,and in the observation group,comprehensive nursing was adopted.The total effectiveness rate,occurrence of complications,and nursing satisfaction of the two groups were compared.Results In the observation group,the total effectiveness rate was 95.24%,significantly higher than that of the control group,accounting for 78.87% (P＜0.05）.The incidence of complications in the observation group was significantly lower than that of the control group(P＜0.05）.The nursing satisfaction of the observation group was significantly higher than that of the control group,the differences were statistically significant(P＜0.05）.Conclusion During perioperative period of perforator flap transplantation to repair soft tissue defect of four limbs,comprehensive nursing intervention can consolidate the treatment effect,reduce the incidence of postoperative complications and increase patient′s nursing satisfaction.
2019 Vol. 26 (8): 244-246 [Abstract] ( 62 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
247 Effect of whole course continuous midwifery nursing in vaginal delivery in second pregnancy after cesarean section
WU Rong-hua
Objective To explore the effect of whole course continuous midwifery nursing in vaginal delivery in second pregnancy after cesarean section.Methods From January 2017 to July 2018,208 pregnant women with vaginal delivery after cesarean section were selected as the study objects.They were divided into experimental group and reference group according to random number table method,104 cases in each group.The reference group was given routine segmental midwifery nursing,while the experimental group was given whole course continuous midwifery nursing.The natural delivery rate,postpartum hemorrhage rate and fetal distress rate were observed and compared between the two groups.The time of delivery was recorded and the satisfaction of the two groups was investigated.Results The natural delivery rate in the experimental group was higher than that in the control group,while the incidence of postpartum hemorrhage and fetal distress was significantly lower than that of the control group(P＜0.05).The average duration of labor in the experimental group was(10.4±2.3)h,which was significantly shorter than that in the control group(12.7±2.8)h(P＜0.05).The satisfaction degree of the pregnant women in the experimental group was 94.23%,which was significantly higher than that in the reference group(76.92%),and the difference was statistically significant(P＜0.05).Conclusion Continuous midwifery nursing can promote natural delivery,shorten the time of labor,reduce complications such as postpartum hemorrhage and fetal distress,and improve nursing satisfaction.It is worthy of further clinical promotion.
2019 Vol. 26 (8): 247-249 [Abstract] ( 71 ) HTML (31 KB)  PDF  (0 KB)  ( 11 )
250 Application effect of extended care in patients with bladder perfusion after bladder cancer operation
LIU Mei-fang
Objective To explore the effect of extended care in patients with bladder perfusion after bladder cancer operation.Methods A total of 100 patients with bladder cancer who were treated in our hospital from January 2016 to December 2017 were selected and divided into control group (50 cases)and study group (50 cases)according to random number table method.The control group was given routine nursing,and the study group was given routine nursing combined with continuous nursing intervention.The self-rating anxiety scale (SAS)scores，self-depression scale(SDS)scores,quality of life scores and nursing satisfaction of the two groups before and after nursing were compared.Results There was no significant difference in the scores of SAS and SDS before nursing between the two groups(P＞0.05）；the scores of SAS and SDS after nursing in the study group were lower than those in the control group (P＜0.05)；the scores of quality of life (including PF,BP,GH,VT,SF,MH）before nursing in the two groups were not significantly different(P＞0.05）.The scores of quality of life (including PF,BP,GH,VT,SF and MH)in the study group were higher than those in the control group (P＜0.05）,and the satisfaction of the study group was higher than that of the control group(P＜0.05）.Conclusion The effect of continuous nursing for patients with bladder perfusion after bladder cancer operation is exact.
2019 Vol. 26 (8): 250-252 [Abstract] ( 62 ) HTML (31 KB)  PDF  (0 KB)  ( 12 )
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