地佐辛对老年患者七氟醚吸入诱导气管插管的影响

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Abstract Objective To investigate the effect of Dizocine on inhaled tracheal intubation induced by Sevoflurane in elderly patients.Methods A total of 50 elderly patients who underwent general anesthesia selective surgery and Sevoflurane inhalation-induced tracheal intubation admitted to our hospital from January 2017 to September 2018 were selected as subjects.According to the random number table method,they were divided into the experimental group(25 cases)and the control group (25 cases).In the experimental group,0.2 mg/kg of Dizocine was injected intravenously before induction of anesthesia,and 10 ml of normal saline was given intravenously before induction of anesthesia in the control group.The demodynamic parameters(cardiac index [CI],central venous pressure [CVP]and oxygen saturation[SpO2]),stress indicators(heart rate[HR],systolic blood pressure[SBP],diastolic blood pressure[DBP],respiratory rate[RR])before injecting drugs(T1),10 min(T2)after injecting drugs,1 min(T3)before tracheal intubation,1 min(T4)after tracheal intubation,and 10 min after tracheal intubation(T5)and the incidence of adverse reactions were compared between the two groups.Results There were no significant differences in CI,CVP and SpO2at T1between the two groups(P＞0.05).The CI,CVP and SpO2in the two groups at T2,T3,T4and T5were lower than those at T1,and the differences were statistically significant(P＜0.05).There were no significant differences in CI and CVP at T2,T3,T4and T5between the two groups (P＞0.05).The SpO2in the experimental group at T2,T3,T4and T5was higher than that in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in HR,SBP,DBP and RR at T1between the two groups(P＞0.05).The HR,SBP,DBP and RR at T2,T3,T4and T5in the experimental group were lower than those at T1,and the differences were statistically significant(P＜0.05).The HR,SBP,DBP and RR at T3,T4and T5in the control group were lower than those at T1,and the differences were statistically significant(P＜0.05).There were no significant differences in HR,SBP,DBP and RR between T1and T2in the control group (P＞0.05).The HR,SBP,DBP and RR at T2,T3,T4and T5in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence rate of adverse reactions during the anesthesia of the experimental group was 4.00%,which was significantly lower than that of the control group(32.00%),and the difference was statistically significant(P＜0.05).Conclusion Dizocine for the inhaled tracheal inhalation induced by Sevoflurane can improve the SpO2of patients,and it has stable hemodynamic parameters,less stress response after intubation,with high drug safety.

Key words： Dezocine Sevoflurane Haemodynamics Stress changes Adverse reaction

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	WAN Lun

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WAN Lun. Effect of Dizocine on inhaled tracheal intubation induced by Sevoflurane in elderly patients[J]. 中国当代医药, 2019, 26(8): 147-150.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I8/147

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