维生素D对体重指数正常妊娠期糖尿病孕妇的血糖控制及妊娠结局的影响

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Abstract Objective To explore the influence of vitamin D(VD)on blood glucose and pregnancy outcome in pregnant women with gestational diabetes mellitus (GDM).Methods From January 2016 to January 2017,280 cases of GDM pregnant women with VD deficiency (＜20 ng/ml)admitted to our hospital were selected as the research object.According to the random method,they were divided into the experimental group and the control group,140 cases in each group.The experimental group was given medical nutrition therapy (MNT)and oral VD 1200 IU/d,and the control group was given MNT and oral VD 400 IU/d.Blood glucose and pregnancy outcomes were compared between the two groups.Results Compared with before treatment,the fasting plasma glucose(FPG)and postprandial 2-hour plasma glucose(2 h PG)of pregnant women in both groups decreased after treatment,and the level of 25-hydroxyvitamin D3(25-[OH]D3)increased after treatment,the difference was statistically significant (P＜0.05).The level of FPG,2 h PG,HbA1c and the incidence rate of hypertension during pregnancy,polyhydramnios,fetal distress,forceps delivery rate,premature delivery,postpartum hemorrhage,prolonged or stagnation labor,neonatal asphyxia,macrosomia in the experimental group were significantly lower than those in the control group,with significant difference (P＜0.05).The rate of spontaneous delivery and the level of 25-(OH)D3in the experimental group was significantly higher than that in the control group,and the difference was significant(P＜0.05).There were no statistically significant differences in the incidence rates of cesarean section,stillbirth,low birth weight children and neonatal hypoglycemia between the two groups(P＞0.05).Conclusion VD is helpful to control the blood glucose of GDM pregnant women,reduce some complications during pregnancy and improve pregnancy outcomes.

Key words： Gestational diabetes mellitus Vitamin D Pregnancy outcome Body mass index

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	YUE Xiao-ling
	ZHAN Fang
	ZHANG Qian

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YUE Xiao-ling,ZHAN Fang,ZHANG Qian. Influence of vitamin D on blood glucose and pregnancy outcome in normal body mass index patients with gestational diabetes mellitus[J]. 中国当代医药, 2019, 26(8): 99-102.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I8/99

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