二甲双胍治疗胰岛素抵抗的复发性流产患者的临床效果

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (32 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the clinical effect of Metformin in the treatment of recurrent spontaneous abortion(RSA)combined with insulin resistance(IR).Methods A total of 100 IR patients with RSA in our hospital from January 2016 to January 2018 were selected.According to treatment options,they were divided into the control group(48 cases)and the observation group (52 cases).The control group received oral Metformin Tablets before pregnancy,stopping Metformin after pregnancy,and Progesterone was used for treatment.The observation group continued to take Metformin Tablets after pregnancy on the basis of the control group.The changes of homeostasis model of assessment for insulin resistence index (HOMA-IR)before and after treatment were observed between the two groups.The pregnancy outcomes and adverse reactions of the two groups were also recorded.Results After treatment,the HOMA-IR of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P＜0.05).The incidence rate of abortion and the total incidence rate of adverse reactions in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Metformin in the treatment of IR patients with RSA has good clinical effect and good safety,which can effectively improve the patients′IR and reduce the abortion rate.

Key words： Recurrent spontaneous abortion Insulin resistance Metformin

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Yan-ni
	ZHOU Zi-qiu
	ZHONG Cui-ping

Cite this article:

ZHANG Yan-ni,ZHOU Zi-qiu,ZHONG Cui-ping. Clinical effect of Metformin in the treatment of insulin resistance patients with recurrent spontaneous abortion[J]. 中国当代医药, 2019, 26(8): 96-98.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I8/96

[1]	中华医学会妇产科学分会产科学组.复发性流产诊治的专家共识[J].中华妇产科杂志，2016，51（1）：3-9.
[2]	张阳佳，朱宝生.复发性自然流产的病因学研究进展[J].中国妇幼保健，2015，30（10）：1637-1640.
[3]	杨学舟，权效珍，邢辉.复发性流产妇女内分泌影响因素分析[J].中国妇幼保健，2017，32（18）：4330-4332.
[4]	母义明，纪立农，宁光，等.二甲双胍临床应用专家共识（2016 年版）[J].中国糖尿病杂志，2016，24（10）：871-884.
[5]	Shahine L，Lathi R.Recurrent pregnancy loss：evaluation and treatment[J].Obstet Gynecol Clin North Am，2015，42（1）：117-134.
[6]	熊焱强，邓小月，李志英.钙网蛋白在自然流产中的相关性研究[J].重庆医学，2016，45（18）：2565-2567.
[7]	梁宝珠，钟春华，李彩娟，等.多囊卵巢综合征所致复发性流产与体重指数、胰岛素抵抗及疗效相关性研究[J].中国优生与遗传杂志，2015，23（4）：77-79.
[8]	Arcidiacono B，Iiritano S，Nocera A，et al.Insulin resistance and cancer risk：an overview of the pathogenetic mechanisms[J].Exp Diabetes Res，2016，2012（6）：383-388.
[9]	赵小萱，陈璐，刘鑫，等.助孕宁Ⅱ号对PCOS早孕先兆流产胰岛素抵抗及炎症因子的干预作用[J].广州中医药大学学报，2017，34（6）：810-814.
[10]	Dodd JM，Crowther CA，Cincotta R，et al.Progesterone supplementation for preventing preterm birth：a systematic review and meta-analysis[J].Acta Obstet Gynecol Scand，2015，84（6）：526-533.
[11]	包春荣，戴虹，余自成.复发性流产的药物治疗进展[J].中国临床药学杂志，2015，24（6）：393-397.
[12]	Harding M，Cowan S，Hole D，et al.Estrogen and progesterone receptors in ovarian cancer[J].Cancer，2015，65（3）：486-491.
[13]	莫紫文，张应亮.二甲双胍及饮食干预改善多囊卵巢综合征孕妇妊娠结局的效果[J].广西医学，2016，38（3）：413-415.
[14]	Bruno S，Ledda B，Tenca C，et al.Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells[J].Oncotarget，2015，6（26）：22 624-22 640.
[15]	王蕴慧，李玲，梁立阳，等.妊娠期间口服二甲双胍对子代生长发育影响的随访观察[J].实用妇产科杂志，2015，31（11）：848-851.