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Quick Search     Adv Search 2018 Vol. 25, No. 29 Published: 2018-10-18   4 Influence of Irbersartan on serum HGF level in the rats with myocardial infarction YU Jun-min;ZHANG Xiao-bo;LI Da-he;ZHAO Yuan-yuan;CHEN Hong-ye Objective To explore the influence of Irbersartan on HGF level in myocardial infarction rats.Methods Myocardial infarction (MI)model was built by ligating the left anterior descending coronary.The survived rats after 24 hours were randomized into the Irbersartan group (n=11)and the control group (n=9),in addition,the sham operation group(n=6)was set up.The Irbesartan group was given Irbesartan(50 mg/[kg·d]).The control group and the sham operated group received the same volume physiological saline by intraperitoneal injection for 4 weeks,the blood was harvested from the posterior orbital vein for 24 hours,and 1,2,4 weeks after surgery,the level of HGF were determined by ELISA.Rats were sacrificed after 4 weeks,and HE staining was used to observe the pathological changes of ischemic myocardium.Results HE staining revealed that the myocardial cells were arranged neatly in the sham operation group,a small amount of inflammatory cell infiltrated.Myocardial cells were dissolving and myocardial structure disordered in the Irbersartan group and the control group,the pathological changes in the Irbersartan group were less than those in the control group.The level of HGF at 24 hours after operation was detected in all groups rats,and there was no significant difference between the each groups(P＞0.05).The level of HGF in the sham operated group after 1 week was lower than that at 24 hours after operation(P＜0.01),and which went up at 2 and 4 weeks,but which was still lower than that at 24 hours after operation (P＜0.01).The levels of HGF in the control group and the Irbesartan group at 1 week were higher than those at 24 hours,and the level of HGF in the control group and the Irbesartan group decreased significantly at 4 weeks,which was lower than that at 1 weeks(P＜0.01).At 1 and 2 weeks,the levels of HGF in the control group and the Irbesartan group were higher than those in the sham operation group (P＜0.01),at 2 and 4 weeks,the level of HGF in the Irbesartan group was significantly lower than that in the control group (P＜0.01).The level of HGF in the control group at 1 and 2 weeks was higher than that at 24 h after operation(P＜0.01),the level of HGF in the control group at 2 and 4 weeks was higher than that at 1 weeks(P＜0.05,P＜0.01).The level of HGF in the Irbesartan group at 4 weeks was lower than that at 24 h and 1 weeks after operation (P＜0.05,P＜0.01).Conclusion Irbersartan can improve the pathological changes of ischemic myocardium for 4 weeks.The serum level of HGF is increased in MI rats,and peaked at 1 week.Irbesartan can reduce serum HGF level after 4 weeks treatment. 2018 Vol. 25 (29): 4-07 [Abstract] ( 167 ) HTML (46 KB)  PDF  (0 KB)  ( 30 ) 8 The preliminary study on the apoptosis of hepatic stellate cells induced by nerve growth factor and its low affinity receptor ZHU Hai-yan;WU Xiong-jian;ZENG Bin;XIE Zhi-jun Objective To observe the effect of nerve growth factor(NGF）and its low affinity receptor(p75 neurotrophin receptor,p75NTR)on the apoptosis and proliferation of rat hepatic stellate cells (HSC),and to explore the possible mechanism of apoptosis.Methods Rat hepatic stellate cells(HSC-T6)were incubated in vitro,HSC-T6 was incubated with NGF and NGF＋p75NTR with different concentrations.The cells were divided into the control group,the NGF group and the NGF＋p75NTR group.The control group was cultured with 0 ng/ml NGF＋0 ng/ml p75NTR,the NGF group was cultured with 100 ng/ml NGF,and the NGF＋p75NTR group was cultured with 100 ng/ml NGF＋100 ng/ml p75NTR.The flow cytometry was used to detect the apoptosis condition.The effect of HSC on the proliferation of NGF and p75NTR was observed by XTT,the expression of P53 and Caspase-3 were detected by immunohistochemical staining.Results The inhibitory effect of the NGF group on the proliferation of HSC was statistically significant(P＜0.05)with the NGF＋p75NTR group and the control group (P＜0.05).The flow cytometry results showed that the apoptosis rate of the control group was lower than that of the NGF group and the NGF＋p75NTR group(P＜0.05),the apoptosis rate of the NGF＋p75NTR group was higher than the NGF group(P＜0.05).The expression of P53 and Caspase-3 in the NGF group and the NGF＋p75NTR group were significantly higher than that in the control group (P＜0.05),the expressions in the NGF＋p75NTR group were significantly higher than that in the NGF group(P＜0.05).Conclusion NGF may inhibit HSC-T6 proliferation and promote its apoptosis through p75NTR,which may be related to the regulation of P53 and Caspase-3 expression. 2018 Vol. 25 (29): 8-10转14 [Abstract] ( 163 ) HTML (38 KB)  PDF  (0 KB)  ( 31 ) 11 Toxicological evaluation of Haematococcus pluvialis soft capsule WANG Yan-wu;QIN Guang-qiu;HE li;PENG Liang;GAO Yu-qiu;WANG Shao-long Objective To evaluate the safety of Haematococcus pluvialis soft capsule.Methods Acute toxicity test,genetic toxicity tests and rat 30 days feeding test were conducted using different doses of Haematococcus pluvialis soft capsule.The differences between the experimental and the control groups were compared.Results No toxic effects of Haematococcus pluvialis soft capsule were observed at doses up to 18 000 mg/(kg·BW)in the acute toxicity test.The results of mice semen abnormality test and mice myeloid cell micronucleus test were all negative,there was no significant difference between the treatment groups and the control group in the 30 days feeding test in terms of body weight,food intake,food utilizing rate,blood biochemistry and hematology (P＞0.05).No apparent pathological injury was observed in rat tissues.Conclusion Haematococcus pluvialis soft capsule is non-toxic and non-mutagenic under the current experimental conditions. 2018 Vol. 25 (29): 11-14 [Abstract] ( 158 ) HTML (39 KB)  PDF  (0 KB)  ( 30 ) 15 Influence of different doses of Oxycodone on catheter-related bladder discomfort during recovery from general anesthesia DENG Jian-ping;JIAO Shou-feng;YANG Yu-jun;LUO He-guo Objective To investigate the influence of different doses of Oxycodone on catheter-related bladder discomfort(CRBD)during recovery from general anesthesia in patients.Methods Ninety male patients with radical gastrectomy for gastric cancer from January to December 2017 in our hospital were selected and divided into the control group,the low dose group and the high dose group according to random number table method,30 cases in each group.Before the end of the operation,the low dose group was intravenously injected with 0.05 mg/kg Oxycodone,and the high dose group was injected with 0.1 mg/kg Oxycodone,and the control group was injected with the same dose of normal saline.The operation condition and hemodynamic changes,Ricker sedation agitation score and CRBD occurrence were recorded during anesthesia recovery stage between the three groups.Results The MAP and HR in the low and high dose group were lower than that in control group,the level of SpO2in the low and high dose group was higher than that in control group at T2and T3,and the MAP and HR in the high dose group were lower than those in the low dose group,the SpO2in the high dose group was higher than that in the low dose group,and the difference was statistically significant(P＜0.05).At T1,there was no significant difference in Ricker sedation-agitation score among the three groups(P＞0.05).At T2and T3,the Ricker sedation agitation score of the low and high group was significantly lower than that of the control group,and the Ricker sedation agitation score of the high dose group was significantly lower than the low dose group,with significant difference(P＜0.05).The degree of CRBD in the low dose group was less than that of the control group,and the degree of CRBD in the high dose group was lower than that in the low dose group,and the difference was statistically significant(P＜0.05).Conclusion Oxycodone of 0.1 mg/kg can effectively prevent catheter related bladder irritation during general anesthesia recovery period. 2018 Vol. 25 (29): 15-17转21 [Abstract] ( 129 ) HTML (45 KB)  PDF  (0 KB)  ( 30 ) 18 Effect of Kanglaite Injection combined with chemotherapy in the treatment of non-small cell lung cancer and its influence on T lymphocyte subsets NING Shang-fu Objective To observe the effect of Kanglaite Injection combined with chemotherapy regimen in the treatment of non-small cell lung cancer and its influence on the level of T lymphocyte subsets and inflammatory factors.Methods Sixty-eight non-small cell lung cancer patients admitted to our hospital from April 2015 to August 2017 were selected and divided into the observation group and the control group according to the random number table method,34 cases in each group.The observation group was given Kanglaite Injection+the GP regimen,and the GP regimen was used to treat the patients in the control group,and 21 d for 1 courses,continuous treatment for 3 courses.Clinical efficacy,T-lymphocyte subsets,inflammatory factors,quality of life,and adverse reactions were observed in the both groups.Results The clinical remission rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the levels of CD3,CD4,CD8,and CD4/CD8 in the observation group were significantly higher than that in the control group,the difference was statistically significant(P＜0.05).After treatment,the levels of IL-2,IL-6 and TNF-α in the observation group were significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).The scores of somatic function,material function,social function,and psychological function in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups during treatment(P＞0.05).Conclusion Kanglaite Injection-assisted GP regimen is effective in the treatment of non-small cell lung cancer,which can significantly improve the patient′s immune function,reduce the level of inflammation,improve the patient′s quality of life,and it is worthy of clinical promotion. 2018 Vol. 25 (29): 18-21 [Abstract] ( 137 ) HTML (40 KB)  PDF  (0 KB)  ( 26 ) 22 Progress in research of universal influenza vaccine based on influenza A virus hemagglutinin ZHANG Jing-jing;WANG Bin;SONG Lu-ping;JING Xin-rui;GUO Bing-feng;MA Chao-yuan;LIANG Xue-shuang;MA Xiao-wei At present,influenza vaccines are designed for the circulating strains,so it is difficult to effectively respond to new strains due to the rapid variation of influenza virus.The trend of future influenza vaccine development is a universal influenza vaccine that can simultaneously protect against multiple influenza virus strains with cross-protection.The research reviews recent general influenza vaccines based on influenza virus hemagglutinin construction in recent years. 2018 Vol. 25 (29): 22-25 [Abstract] ( 145 ) HTML (45 KB)  PDF  (0 KB)  ( 35 ) 26 Clinical effect of decompression and craniotomy for bilateral craniocerebral injury WU Qiong;XIONG Xiao-bing;LI Xiao-hong;ZHANG Jie-hui Objective To investigate the clinical effect of decompression and craniotomy for bilateral craniocerebral injury.Methods From July 2012 to December 2017,40 patients with bilateral craniocerebral injury were selected as the study objects.They were divided into study group(20 cases)and control group(20 cases)according to random number table method.The patients in the study group were treated with decompression of bone flap,while the patients in the control group were treated with unilateral standard large bone flap decompression.The treatment effect and the incidence of postoperative complications (acute encephalocele and incisional hernia)were compared between the two groups.Results The total effective rate of the study group was 80.00%,which was higher than that of the control group(60.00%),the differences were statistically significant(P＜0.05).The incidence of postoperative complications,such as acute encephalocele and incisional hernia,which was 20.00%in the study group,lower than that in the control group(55.00%),the differences were statistically significant(P＜0.05).Conclusion The treatment of bilateral craniocerebral injury with deossed-bone flap decompression is effective in improving the effective rate of clinical treatment,reducing the incidence of acute encephalocele and incisional hernia,and improving the prognosis of the patients,which is worthy of clinical application. 2018 Vol. 25 (29): 26-28 [Abstract] ( 127 ) HTML (38 KB)  PDF  (0 KB)  ( 34 ) 29 Effect of laparoscopy on acute appendicitis and its influence on serum procalcitonin and C-reactive protein levels OUYANG Zhao-han Objective To investigate the effect of laparoscopic surgery on patients with acute appendicitis and its influence on serum procalcitonin (PCT)and C-reactive protein (CRP)levels.Methods A total of 110 patients with acute appendicitis admitted to our hospital from April 2016 to September 2017 were selected as subjects.They were randomly divided into two groups according to the order of admission:laparoscopic appendectomy group (laparoscopic group,n=55)and appendectomy by laparotomy group (laparotomy group,n=55).The operation time,intraoperative blood loss,the time of getting out of bed,the recovery time of intestinal function and the hospital stay after surgery were compared between the two groups.The postoperative complications of the two groups were compared.The serum PCT and CRP levels on the 1st day and 3rdday after laparoscopic surgery were compared between the two groups.Results The operation time in the laparoscopic group was longer than that in the laparotomy group,the intraoperative blood loss in the laparoscopic group was less than that in the laparotomy group,the time of getting out of bed,the recovery time of intestinal function and the hospital stay after surgery in the laparoscopic group were greatly shorter than those in the laparotomy group,the differences were statistically significant(P＜0.05).The total incidence of postoperative complications in the laparoscopic group was significantly lower than that in the laparotomy group with a statistical difference (P＜0.05).First day after surgery,the PCT and CRP levels were both higher in the two groups than prior surgery,the differences were statistically significant(P＜0.05).Three-day after surgery,the serum PCT and CRP levels in the two groups were significantly lower than those on the first day after surgery,the differences were statistically significant(P＜0.05).However,the serum PCT and CRP levels three days after surgery in the laparoscopic group were not greatly different from those before surgery (P＞0.05),while in the laparotomy group,the serum PCT and CRP levels were significantly higher than those before surgery,the differences were statistically significant(P＜0.05).The serum PCT and CRP levels on the 1st day and 3rd day after laparoscopic surgery were significantly lower than those in the laparotomy group,the differences were statistically significant(P＜0.05).Conclusion The clinical effect of laparoscopic surgery for patients with acute appendicitis is remarkable,which can reduce the inflammatory response in the body and has high safety. 2018 Vol. 25 (29): 29-32 [Abstract] ( 142 ) HTML (42 KB)  PDF  (0 KB)  ( 23 ) 33 Predictive value of hyperbilirubinemia in acute suppurative gangrenous appendicitis TAO Hong-fa;ZHAO Kun;XIAO Yong;ZHANG Chao;YE Yuan-li;REN Peng-zhen;HE Xiao-yu Objective To evaluate the predictive value of hyperbilirubinemia in the diagnosis of acute purulent gangrenous appendicitis.Methods A total of 226 patients with acute appendicitis who were admitted to our hospital from January 2010 to January 2018 were selected as research subjects,serum total bilirubin(TBil),C-reactive protein(CRP)and white blood cell count(WBC)were detected in all patients before operation,the patients were divided into simple appendicitis group (51 cases),acute pyogenic gangrenous appendicitis group (129 cases)and perforating appendicitis group (46 cases)according to postoperative pathology,the incidence of hyperbilirubinemia,serum bilirubin,CRP and WBC levels were recorded,the sensitivity and specificity of acute pyogenic gangrenous appendicitis were predicted by Alavrdo score.Results The incidence of hyperbilirubinemia,postoperative complications,Alvardo score,WBC,TBil and CRP levels in simple appendicitis group were lower than those in pyogenic gangrenous appendicitis group and perforating appendicitis group(P＜0.05),the duration of abdominal pain and postoperative hospitalization were shorter than those of pyogenic gangrenous appendicitis group and perforating appendicitis group (P＜0.05);There was no significant difference in the incidence of hyperbilirubinemia and postoperative complications between pyogenic gangrenous appendicitis group and perforating appendicitis group(P＞0.05);The duration of abdominal pain and postoperative hospitalization in pyogenic gangrenous appendicitis group were shorter than those in perforating appendicitis group (P＜0.05),alvardo scores,WBC,TBil and CRP levels were lower than those in the perforated appendicitis group(P＜0.05).The sensitivity,specificity,positive predictive value and negative predictive value of acute pyogenic gangrenous appendicitis were 89.5%,91.6%,85.7%and 93.8%respectively,when serum bilirubin level＞21.3 mol/L,sensitivity and specificity were significantly higher than those of WBC,CRP and Alavrdo scores(P＜0.05).Conclusion Hyperbilirubinemia has better predictive value in the diagnosis of acute suppurative gangrenous appendicitis. 2018 Vol. 25 (29): 33-36 [Abstract] ( 147 ) HTML (42 KB)  PDF  (0 KB)  ( 36 ) 37 Effectiveness and safety of endoscopic ligation combined with drug injection in the treatment of cirrhosis complicated with upper digestive hemorrhage ZOU Zi-wan;GUO Wei-qiang Objective To explore the effectiveness and safety of endoscopic ligation combined with drug injection in the treatment of cirrhosis complicated with upper digestive hemorrhage.Methods A total of 50 patients with cirrhosis and upper digestive hemorrhage admitted to our hospital from January 2015 to December 2017 were enrolled,they were randomly divided into observation group and control group with 25 cases in each group,patients in control group received conservative treatment in hospital,patients in observation group received endoscopic ligation combined with drug injection on the basis of conservative treatment.The hemostasis time,hospitalization time,rebleeding and hemodynamics before and after treatment were compared between the two groups.Results The amount of blood transfusion in the observation group was less than that in the control group,and the hemostasis time,symptom improvement time and hospitalization time were shorter than those in the control group,the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statiscally significant(P＜0.05).The portal venous blood flow and splenic venous blood flow in the observation group were fewer than those in the control group (P＜0.05).The re-bleeding rate in the observation group was lower than that in the control group,the difference was statiscally significant(P＜0.05).Conclusion Endoscopic ligation combined with drug injection is effective in the treatment of cirrhosis complicated with upper gastrointestinal hemorrhage,which can effectively improve the varicose hemodynamics and reduce the probability of re-bleeding. 2018 Vol. 25 (29): 37-39 [Abstract] ( 165 ) HTML (38 KB)  PDF  (0 KB)  ( 32 ) 40 Effect of aerobic exercise on erectile dysfunction in young and middleaged patients with coronary heart disease ZENG Hui-qing;FANG Xiang-yan;CHEN Zhao-yang Objective To investigate the effect of aerobic exercise on erectile dysfunction (ED)in young and middleaged patients with coronary heart disease(CHD).Methods From January 2015 to August 2016,60 patients with chronic stable coronary heart disease aged 22-60 years in the Second People′s Hospital of Shunde District of Foshan City were selected and divided into the treatment group and the control group according to random number table method,30 cases in each group.In the treatment group,12 weeks of aerobic exercise and second-prevention drug therapy on CHD were used,while in the control group,12 weeks of second-prevention drug therapy on CHD alone was adopted.The therapeutic effects of the two groups were compared.Results There was significant difference in the simplified IIEF-5 scores between after treatment and before treatment in the two groups(P＜0.05).There was significant difference in the simplified IIEF-5 scores between after treatment in the treatment group and after treatment in the control group (P＜0.05).The cure rate of the treatment group was higher than that of the control group,and the difference was statistically significant(P＜0.05).In the two group,there was no adverse reactions such as chest pain,syncope or fall occurred during the study.Conclusion Aerobic exercise is effective in treating ED in young and middle-aged patients with CHD,it is worthy of clinical promotion and application. 2018 Vol. 25 (29): 40-42转57 [Abstract] ( 137 ) HTML (40 KB)  PDF  (0 KB)  ( 25 ) 43 Clinical efficacy of Trimetazidine combined with Metoprolol Succinate in the treatment of coronary heart disease with heart failure ZHU Ling-hua;ZHU Ming-zhen Objective To investigate the clinical effect of Trimetazidine combined with Metoprolol Succinate in the treatment of coronary heart disease (CHD)with heart failure.Methods A total of 100 CHD patients with heart failure treated in our hospital from February 2015 to March 2017 were selected,they were divided into the experimental group(n=50)and the control group (n=50)according to block randomization method.The control group received Metoprolol Succinate on the basis of basic treatment,while the experimental group received Trimetazidine and Succinate on the basis of basic treatment.The therapeutic effects,blood pressure,heart rate (HR),left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),plasma brain natriuretic peptide (BNP)and the incidence rate of adverse reactions were compared between the two groups.Results The total effective rate(96.00%)in the experimental group was higher than that in the control group(82.00%),and the difference was statistically significant(P＜0.05).The blood pressure,heart rate,LVESD and LVEDD levels in the experimental group were lower than those in the control group,and the levels of LVEF and BNP in plasma in the experimental group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the experimental group (8.00%)was lower than that in the control group(40.00%),the difference was statistically significant(P＜0.05).Conclusion Trimetazidine combined with Metoprolol Succinate can improve the therapeutic effect and cardiac function of CHD patients with heart failure,and it is safe to use Trimetazidine and Metoprolol Succinate. 2018 Vol. 25 (29): 43-45 [Abstract] ( 164 ) HTML (36 KB)  PDF  (0 KB)  ( 30 ) 46 Influence of endocrine therapy on blood lipids and bone health in postmenopausal women with breast cancer WANG Qin;LI De-jun;WU Yu-ping Objective To analyze the influence of endocrine therapy on blood lipids and bone health in postmenopausal women with breast cancer.Methods A total of 105 cases of postmenopausal breast cancer patients admitted to our hospital from April 2016 to April 2017 were selected as the research objects.All patients were randomly divided into groups A,group B,group C,with 35 cases in each group.Group A was given Letrozole and Anastrozole,group B was treated with Exemestane,and group C was treated with Tamoxifen.The changes of blood lipid level and bone mineral density (BMD)were compared between the three groups before treatment and 12 months after treatment.Results The levels of total cholesterol(TC),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)in group A and group B were higher than those before treatment,with significant difference (P＜0.05).The levels of TC and LDL-c after treatment in group C were lower than those before treatment,and the levels of TG and HDL-C after treatment in group C were higher than those before treatment,with significant difference(P＜0.05).The level of TC after treatment in group A was higher than that in group B and group C,with significant difference (P＜0.05).The levels of TC and LDL-C after treatment in group C were lower than those in group A and group B,with significant difference (P＜0.05).The BMD of the lumbar spine and left hip after treatment in the three groups were lower than those before treatment,with significant difference (P＜0.05).The BMD of the lumbar spine and left hip after treatment in group C were higher than those in group B and group A,with significant difference(P＜0.05).Conclusion Letrozole,Analtriazole,Etoxetin,and Tamoxifen are all effective drugs for adjuvant endocrine therapy in postmenopausal breast cancer patients,but Tamoxifen is superior to the other three drugs in blood lipids and BMD. 2018 Vol. 25 (29): 46-48 [Abstract] ( 165 ) HTML (37 KB)  PDF  (0 KB)  ( 28 ) 49 Expression of GLI1 in colon cancer and its relationship with epithelialmesenchymal transformation LIN Zhi-ping;DUAN Zhao;XIONG Ping-xiang;HUANG Jie-ping;MEI Rui-ping;YANG De-ping Objective To observe the relationship between the expression of GLI1 and epithelial-mesenchymal transformation in colon cancer.Methods From January 2010 to December 2015,altogether 50 specimens of surgically resected colon cancer and adjacent tissues from Jiangxi Integrated Hospital of Traditional Chinese and Western Medicine were collected and made into tissue microarrays.Immunohistochemical SP method was used to detect the expression of GLI1,Vimentin,N-cadherin and E-cadherin in colon cancer tissues and adjacent tissues.Results The expression of GLI1 in the colon cancer was higher than that in the adjacent tissues,with statistically significant difference (P＜0.05),which was significantly correlated with lymphatic metastasis,clinical stage and tumor differentiation of colon cancer(P＜0.05).The expression of E-cadherin in the adjacent tissues was higher than that in the colon cancer,with statistically significant difference (P＜0.05),which was significantly correlated with lymphatic metastasis,clinical stage and tumor differentiation of colon cancer(P＜0.05).The expression of vimentin and N-cadherin were higher in the colon cancer than that in the adjacent tissues,with statistically significant difference (P＜0.05),which was significantly associated with lymphatic metastasis,clinical stage,and tumor differentiation of colon cancer(P＜0.05).The expression of GLI1 was associated with the state of epithelial-mesenchymal transformation (P＜0.05).Conclusion The expression of GLI1 in the colon cancer is related to Vimentin,N-cadherin and E-cadherin.It is indicated that GLI1 may participate in the epithelial-mesenchymal-transformation process. 2018 Vol. 25 (29): 49-51转66 [Abstract] ( 134 ) HTML (39 KB)  PDF  (0 KB)  ( 138 ) 52 Expression of p140Cap in breast cancer and its clinical significance TONG Hui Objective To investigate the expression and clinical significance of p140Cap in breast cancer.Methods A total of 246 cases of primary breast cancer from June 2012 to June 2017 in our hospital were selected as the case group,and 60 cases of adjacent tissues of breast cancer were selected as the control group.Immunohistochemical technique was used to detect the expression levels of p140Cap gene in the two groups.The expression levels of p140Cap gene in breast cancer and normal breast tissue,the expression levels and correlation of different molecular classifications of breast cancer and in different clinical parameters were analyzed by statistical method.Results The expression of p140Cap was significantly decreased or absent in breast cancer tissues,and which was significantly different from that in para-carcinoma tissues(P＜0.05).The expression of p140Cap was related with the tumor diameter,age,axillary lymph node metastasis,histological grading,estrogen receptor status,progesterone receptor status,and human epidermal growth factor receptor status,but not to tumor stage.Conclusion p140Cap is lowly expressed in breast cancer tissues and correlates with clinicopathological types of breast cancers in some prognosis,which affects the poor prognosis of breast cancer. 2018 Vol. 25 (29): 52-54 [Abstract] ( 150 ) HTML (35 KB)  PDF  (0 KB)  ( 138 ) 55 Expression and clinical significance of miR-92 in epithelial ovarian cancer HU Ping;PENG Wei;WU Ming-tao;LIU Ting Objective To investigate the expression and clinical significance of miR-92 in epithelial ovarian cancer.Methods From January 2007 to December 2017,altogether 300 cases of patients with epithelial ovarian cancer,300 cases of benign ovarian tumor,and 300 patients who underwent unilateral or bilateral ovariectomy because of benign lesions of reproductive organs(except ovary)were selected as the research objects.The real-time fluorescence quantitative assay was used to detect the expression of miR-92 in ovarian cancer,benign ovarian tumor and normal ovarian tissues.Results The level of miR-92 in ovarian cancer group was higher than that in ovarian benign tumor group and normal ovarian group,and the difference was statistically significant(P＜0.05).The level of miR-92 in ovarian cancer group was related to lymph node metastasis,clinical stage and tumor differentiation (P＜0.05).Conclusion The level of miR-92 expression can be used as a clinical basis for the diagnosis of epithelial ovarian cancer. 2018 Vol. 25 (29): 55-57 [Abstract] ( 148 ) HTML (34 KB)  PDF  (0 KB)  ( 25 ) 58 Effect observation of preburial double-barrelled negative pressure drainage tube after radical mastectomy for the prevention of postoperative skin flap necrosis and effusion CHEN Jun Objective To investigate the effect of preburial double-barrelled negative pressure drainage tube after radical mastectomy for the prevention of postoperative skin flap necrosis and effusion.Methods A total of 96 patients who underwent radical mastectomy in our hospital from February 2016 to October 2017 were selected as the research subjects.According to the time of admission,they were divided into the observation group and the control group,48 cases in each group.The patients in the observation group were treated with axillary and parastnal double tube drainage,while the control group was treated with conventional axillary single tube drainage.The postoperative subcutaneous fluid,flap necrosis and incision infection,the time of extubation and hospital stay were compared between the two groups.Results The incidence of flap necrosis,fluid accumulation and incision infection after intubation in the observation group were significantly lower than those in the control group,with significant difference(P＜0.05).The extubation time and length of stay in the observation group were significantly shorter than those in the control group,with significant difference (P＜0.05).Conclusion The effect of preburial double-barrelled negative pressure drainage tube in the prevention of postoperative skin flap necrosis is significant,and it is one of the key factors for postoperative prognosis.It is worth popularizing in clinical application. 2018 Vol. 25 (29): 58-60 [Abstract] ( 144 ) HTML (33 KB)  PDF  (0 KB)  ( 29 ) 61 Evaluation on the effect of whole brain radiotherapy combined with Temozolomide in the treatment of brain metastases of non-small cell lung cancer WAN Lin-lin;LIU Xiao-hong;CHEN Kai Objective To observe the efficacy and side effects of whole brain radiotherapy Combined with Temozolomide in the treatment of brain metastases of non-small cell lung cancer(NSCLC).Methods A total of 56 patients with NSCLC in our hospital from May 2014 to May 2017 were selected as the study objects.According to the random grouping method,all the patients were divided into the study group and the control group,with 28 cases in each group.The study group received whole brain radiotherapy combined with Temozolomide Capsules chemotherapy,whole brain radiotherapy dose was 40 GY/20 F,Temozolomide dose was 75 mg/(m2·d).The control group was treated with simple whole brain radiotherapy,and the dose and method of radiotherapy were the same as those of the study group.The treatment related adverse reactions were compared between the two groups during the treatment and after the end of the treatment.After 1 month at the end of the radiotherapy,the brain enhanced MRI was reviewed,and the total effective rate (RR),the progression free survival period and the total survival period were compared between the two groups.Results The total effective rate (RR)of the study group was higher than that of the control group,with significant difference (P＜0.05).The median progression free survival of the study group was 3.9 months,which was higher than that of the control group for 2.8 months,and the difference was statistically significant(P＜0.05).The median overall survival of the study group was 6.1 months,which was 5.2 months in the control group,there was no significant difference between the two groups(P＞0.05).In the study group of adverse reactions,most of them were granulocytic,digestive tract reaction and headache and dizziness,all of which were gradeⅠ toⅡ.There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).All adverse reactions did not affect radiotherapy after symptomatic treatment.Conclusion whole brain radiotherapy combined with Temozolomide in the treatment of NSCLC brain metastases is highly effective in the near future,and can prolong the progression free survival,the adverse reaction is small,and the patient is well tolerated. 2018 Vol. 25 (29): 61-63转72 [Abstract] ( 147 ) HTML (36 KB)  PDF  (0 KB)  ( 26 ) 64 Clinical study of intravesical instillation of Doxorubicin Liposomes in the prevention of postoperative recurrence of bladder cancer YANG Rong-chen;XUE Gang Objective To investigate the efficacy and safety of Doxorubicin Liposome in the prevention of postoperative recurrence of bladder cancer by intravesical instillation.Methods A total of 75 patients with superficial bladder cancer who were treated in our hospital from February 2013 to March 2015 were selected as the study subjects.They were divided into the control group(37 cases)and the treatment group(38 cases)according to the sequential order of surgery.The control group was given Pirarubicin bladder infusion,and the treatment group was given Doxorubicin Liposome bladder infusion method.The recurrence rate and the total incidence rate of adverse reactions were compared between the two groups.Results The follow-up period was 2 years.The recurrence rate 24 months after treatment in the treatment group was 18.42%,which was lower than that in the control group (35.14%),and the difference was statistically significant(P＜0.05).The total incidence rate of adverse reactions in the treatment group was 26.31%,which was lower than that in the control group(62.16%),and the difference was statistically significant(P＜0.05).ConclusionIntravesical instillation of Doxazosin Liposomes is effective in the prevention of postoperative recurrence of bladder cancer. 2018 Vol. 25 (29): 64-66 [Abstract] ( 158 ) HTML (35 KB)  PDF  (0 KB)  ( 28 ) 67 Clinical application value of Fanlesheng for non-invasive and painless delivery in maternal natural delivery NING Jie Objective To observe and analyze the clinical application value of Fanlesheng for non-invasive and painless delivery in maternal natural delivery.Methods From January 2017 to April 2018,137 cases of healthy full-term clinical puerpera who were admitted to the department of gynecology and obstetrics in our hospital were selected as the subjects.They were divided into experimental group(n=70)and control group(n=67)according to random number table method.The control group was given conventional analgesia for delivery.The experimental group was given Fanlesheng for non-invasive and painless delivery.The maternal labor time,delivery status and recovery of lactating function were compared between the two groups.Results After delivery,the first labor,second labor and third labor time of the puerpera in the experimental group were significantly shorter than those in the control group (P＜0.05).The visualoganalog score(VAS)score in the experimental group was significantly lower than that in the control group(P＜0.05).The sensory block time and exercise block time in the experimental group were significantly shorter than those in the control group(P＜0.05).The postpartum hemorrhage in the experimental group was significantly less than that in the control group(P＜0.05).The Cesarean section rate in the experimental group (4.29%)was significantly lower than that in the control group(23.88%)(P＜0.05).After delivery,the starting time of lactation in the experimental group was significantly earlier than that in the control group(P＜0.05).The concentration of prolactin(PRL)in the two groups was significantly higher than that before delivery.The concentration of PRL in the experimental group was significantly higher than that in the control group(P＜0.05).Conclusion Fanlesheng for non-invasive and painless technique applied to the maternal natural delivery process is beneficial to effectively alleviating maternal pain and reducing the amount of bleeding,and thereby shorten maternal sensation,motor block time and labor time,improve maternal natural delivery rate and promote the recovery of lactating function,which is worthy of clinical promotion and application. 2018 Vol. 25 (29): 67-69 [Abstract] ( 136 ) HTML (37 KB)  PDF  (0 KB)  ( 21 ) 70 Application effect of targeted intervention in advanced age multipara pregnancy and childbirth WANG Jing;ZHU Yi-lin Objective To explore the application effect of targeted intervention in advanced age multipara pregnancy and childbirth.Methods Eighty-six advanced multiparae were admitted to department of gynecology and obstetrics,Zhuanyang Community Health Service Center of Zhuanyang street,Wuhan economic and technological development zone,from July 2016 to February 2018 were selected as the study subjects,according to the random number table method,they were divided into control group(43 cases)and observation group(43 cases),the observation group was given targeted intervention,while the control group received regular inspection according to the doctor's advice.The tatal incidence of pregnancy complications (gestational hypertension,placenta previa,premature delivery,late pregnancy)and total satisfaction were compared between the two groups.Results The total incidence of pregnancy complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).The total satisfaction rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion It is of high clinical value to implement targeted intervention during advanced age multipara pregnancy,it can ensure the safety of pregnant women and fetuses on the basis of reducing the incidence of complications,which is worthy of application and promotion. 2018 Vol. 25 (29): 70-72 [Abstract] ( 134 ) HTML (32 KB)  PDF  (0 KB)  ( 30 ) 73 Clinical efficacy of cefoperazone sodium and sulbactam sodium in treatment of children with lower respiratory tract infection WU Shu-ying Objective To explore the efficacy of cefoperazone sodium and sulbactam sodium in children with lower respiratory tract infection.Methods A total of 70 children with lower respiratory tract infection admitted to our hospital from December 2016 to December 2017 were selected as the research subjects,the children were randomly divided into the control group and the observation group according to the No.ID of the children,with 35 cases in each group.The control group was treated with Azithormycin,while the observation group was treated with cefoperazone sodium and sulbactam sodium,the clinical effects of the two groups were compared and analyzed,and the bacterial clearance rate was tested.The incidence of adverse reactions was compared between the two groups.Results The total effective rate of the observation group(94.28%)was significantly higher than that of the control group(77.14%),the difference was statistically significant(P＜0.05).The average clearance rate ofStreptococcus pneumoniae,Klebsiella pneumoniae,Escherichia coli,Pseudomonas aeruginosa,Enterobacter cloacae,Proteus and other pathogens in the observation group (91.43%)were significantly higher than those in the control group(71.43%),the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the observation group (0.00%)was significantly lower than that in the control group (5.71%)(P＜0.05).Conclusion Cefoperazone Sodium Sulbactam Sodium in the treatment of children with lower respiratory tract infection has a significant effect,can improve the bacterial clearance rate,reduce the incidence of adverse reactions. 2018 Vol. 25 (29): 73-75 [Abstract] ( 123 ) HTML (34 KB)  PDF  (0 KB)  ( 22 ) 76 Clinical efficacy of Montelukast Sodium combined with inhaled corticosteroids in the treatment of children with asthma GU Ting-ting Objective To explore the clinical effect of Montelukast Sodium combined with inhaled corticosteroids in the treatment of children with asthma.MethodsEighty children with asthma admitted to our hospital from January 2017 to January 2018 were selected as the study subjects and randomly divided into control group(40 cases)and observation group(40 cases)according to random sampling,the control group was treated with Budesonide,while the observation group was treated with Montelukast Sodium combined with Budesonide.The clinical efficacy,pulmonary function indexes(FEV1,PEF),the time of disappearance of symptoms length of stay and total incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group after treatment was higher than that of the control group,the difference was statistically significant(P<0.05).The lung function indexs of the observation group after treatment were higher than those of the control group,the difference was statistically significant(P<0.05).The Length of stay and the time of disappearance of symptoms in the observation group were shorter than those of the control group,the differences were statistically significant(P<0.05).Conclusion The clinical effect of Montelukast sodium combined with inhaled glucocorticoid in the treatment of children with asthma is very obvious,and it can improve the pulmonary function of children,shorten hospital stay,worthy of clinical promotion and application. 2018 Vol. 25 (29): 76-78 [Abstract] ( 140 ) HTML (35 KB)  PDF  (0 KB)  ( 25 ) 79 Efficacy of live Clostridium Butyricum powder combined with blue light phototherapy treatment of neonatal hyperbilirubinemia ZHAO Wei-kun;HUANG Gui-hua Objective To explore the feasibility of live clostridium butyricum Powder combined with blue light phototherapy treatment of neonatal with hyperbilirubinemia.Methods A total of 384 cases neonate with hyperbilirubinemia in our hospital from January 2016 to January 2018 were selected and randomly divided into the control group and the observation group according to random number table,192 cases in each group.Two groups of children were given the same dose of blue light irradiation treatment,observation group of children with blue light treatment and given Clostridium Butyricum powder 1.5 g/d,oral three times.The levels of bilirubin were measured before treatment and 1,4 and 7 days after treatment.The daily average decrease of bilirubin,the disappearance time of jaundice and the occurrence of adverse reactions were calculated and compared.Results There was no significant difference in bilirubin levels between the two groups before treatment(P＞0.05),after treatment,the bilirubin levels of the two groups were significantly lower than those before treatment(P＜0.05),the bilirubin level in the observation group after treatment for 4 and 7 d was significantly lower than that in the control group (P＜0.05).The average daily decrease of bilirubin in the observation group was significantly higher than that in the control group(P＜0.05),and the disappearance time of jaundice was significantly shorter than that in the control group (P＜0.05).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group (P＜0.05).Conclusion Live Clostridium Butyricum Powder combined with blue light phototherapy in treatment of neonatal hyperbilirubinemia can improve the curative effect,shorten the treatment time and reduce adverse reactions.It is worth promoting in clinical practice. 2018 Vol. 25 (29): 79-81 [Abstract] ( 132 ) HTML (35 KB)  PDF  (0 KB)  ( 26 ) 82 Influence of laparoscopic uterine artery ascending branch blocking assisted hysteromyomectomy on ovarian and sexual function SONG Yun-hong Objective To study the influence of laparoscopic uterine artery ascending branch blocking assisted hysteromyomectomy on ovarian function and sexual function.Methods The data of 60 patients with uterine myoma who were confirmed in our hospital from January 2014 to January 2017 were retrospectively analyzed.All the patients were divided into group A and group B according to the different surgical methods,with 30 cases in each group.Group A underwent laparoscopic uterine artery ascending branch blocking assisted hysteromyomectomy.Group B underwent laparoscopic total hysterectomy(TLH).After two surgical procedures,the ovarian function,sexual life quality and other indicators were analyzed.Results The intraoperative blood loss in group A was less than that in group B,the operation time,postoperative exhaust time and hospitalization time were shorter than those in group B(P＜0.05).There were no statistically significant differences in follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estrogen(E2)of group A at postoperational 6 months in contrast with those before operation(P＞0.05).FSH and LH levels of group B were significantly higher than those before operation,and E2of group B was significantly lower than that before operation,with statistically significant difference (P＜0.05).After operation the FSH and LH levels in group A were lower than those in group B,E2 levels was higher than that in group B,with statistically significant difference(P＜0.05).The sexual function of group A was higher than that of group B(P＜0.05).Conclusion Laparoscopic uterine artery ascending branch blocking assisted hysteromyomectomy is featured with less haemorrhage,rapid recovery,less impact on ovarian function and sexual function,and retention of fertility,which enables patients to have higher quality of life,and is worthy of clinically rational use. 2018 Vol. 25 (29): 82-84 [Abstract] ( 118 ) HTML (37 KB)  PDF  (0 KB)  ( 27 ) 85 Effect of Cinnidine combined with Live Lactobacillus Capsule for vsginal use in the treatment of vulvovaginal candidiasis in pregnant women HONG Ya-xue Objective To evaluate the clinical effect of Cinnidine combined with Live Lactobacillus Capsule for vsginal use in the treatment of vulvovaginal candidiasis in pregnant women.Methods From December 2016 to December 2017,180 cases of vulvovaginal candidiasis in pregnant women admitted to our hospital were selected as combination group,and treated with Cortinafine and Live Lactobacillus Capsule for vsginal use.The other one was treated in the same period,180 cases of pregnant women with vulvovaginal candidiasis who were seleced as the single group,and taken cortisol treatment.The treatment effect,the incidence of adverse reactions and recurrence rates were compared between the two groups.Results The treatment effect in the combined group(93.3%)was higher than that in single group(82.2%)(P＜0.05).The incidence of adverse reactions in combination group(3.3%)was lower than that in single group(15.6%)(P＜0.05).The relapse rate in combination group(1.1%)was lower than that in single group(6.5%)(P＜0.05).Conclusion The treatment of vulvovaginal candidiasis in pregnant women taking Cinnidine combined with Live Lactobacillus Capsule for vsginal use effectively improves the treatment effect,reduces the chance of recurrence,and has high safety.Pregnant women can use it safely. 2018 Vol. 25 (29): 85-87 [Abstract] ( 126 ) HTML (34 KB)  PDF  (0 KB)  ( 30 ) 88 The value of HbA1c in the diagnosis of gestational diabetes during early pregnancy CHEN Xiao-jie;TAO Hua-qing;JIANG Li Objective To investigate the value of HbA1c in the diagnosis of gestational diabetes during early pregnancy.Methods Pregnant women who had undergone a pregnancy test in our department from June 2015 to October 2017 were selected.Among them,98 cases of pregnant women diagnosed with gestational diabetes were chosen as the experimental group,while 100 cases of pregnant women undergoing normal pregnancy tests were chosen as the control group.Fasting plasma glucose(FPG),glucose tolerance test(OGTT)2 h blood glucose,and HbA1c were detected in both groups.The differences in FPG,2 h blood glucose,and HbA1c were analyzed between the two groups of pregnant women,and the positive rate,diagnostic sensitivity,and specificity were compared.Results The FPG,2 h blood glucose,HbA1c and positive rate of the experimental group were higher than those of the control group (P＜0.05).The FPG detection sensitivity was 77.5%,specificity was 89.3%,2 h blood glucose detection sensitivity was 87.8%,specificity was 98.0%,HbA1c detection sensitivity was 85.7%,specificity was 95.2%.Conclusion The clinical detection of glycated hemoglobin in early pregnancy has a certain diagnostic value for the diagnosis of gestational diabetes.It can be used as an important indicator for the early screening of gestational diabetes,and it is worthy of promotion in clinical practice. 2018 Vol. 25 (29): 88-90 [Abstract] ( 130 ) HTML (33 KB)  PDF  (0 KB)  ( 22 ) 91 Expression and significance of TLR4 and NF-κB in villi and decidua of patients with missed abortion YANG Xiu-lian Objective To investigate the expression and clinical significance of Toll-like receptor 4(TLR4)and nuclear factor-kappaB (NF-κB)in the villi and decidua of patients with missed abortion.Methods A total of 90 patients with missed abortion treated in our hospital from January 2013 to October 2017 were selected(50 patients with missed abortion and infection were group A,40 patients with missed abortion and no infection were group B)and 50 normal early pregnancy required termination of pregnancy (group C).Immunehisto-chemical SP method was used to detect the expression of TLR4 and NF-κB in chorionic villi and decidua.Results TLR4 and NF-κB were expressed in the three groups of villi and decidua,but the expression of TLR4 and NF-κB in the villi and decidua of group A and B was higher than that of the group C (P＜0.05).There was a positive correlation between the expression of TLR4 and NF-κB in the same villi and decidua in group A (r=0.527,P＜0.05).Conclusion The expression of TLR4 and NF-κB in the villus and decidua of patients with missed abortion is increased,which may be involved in the occurrence and development of missed abortion. 2018 Vol. 25 (29): 91-93转96 [Abstract] ( 122 ) HTML (38 KB)  PDF  (0 KB)  ( 18 ) 94 Effect observation of sublingual allergen specific immunotherapy in the treatment of allergic asthma in children HUA Tong Objective To observe the effect of sublingual allergen specific immunotherapy on allergic asthma in children.Methods A total of 58 cases children with allergic asthma treated in our hospital from October 2016 to October 2017 were selected as the subjects,and all the children were randomly divided into the observation group and the control group,with 29 cases in each group.The control group was treated with Inhaled Budesonide Aerosol,and the observation group was given Dermatophagoides Farinae Drops by sublingual administrntion.The changes of serum interferon gamma(IFN-gamma)and interleukin-4(IL-4)were compared before and after treatment,and the effect of clinical treatment was compared.Results The levels of IFN-gamma and IL-4 in the two groups were significantly improved after treatment compared with those before treatment(P＜0.05).After treatment,the level of IFN-gamma in the observation group was higher than that in the control group,and the IL-4 level was lower than that in the control group,the differences were statistically significant (P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion The treatment of sublingual Dermatophagoides Farinae Drops specific immunotherapy in the treatment of allergic asthma in children is beneficial to improve the symptoms of asthma in children.It is effective in clinical treatment,and is worthy of further clinical application. 2018 Vol. 25 (29): 94-96 [Abstract] ( 113 ) HTML (32 KB)  PDF  (0 KB)  ( 22 ) 97 Effect comparison of Vitapex paste and traditional root canal paste in the treatment of periapical periodontitis HUANG Hong-qiong;REN Quan-zhi;LI Hai-feng Objective To compare the effects of Vitapex paste and traditional root canal paste in the treatment of periapical periodontitis.Methods A total of 210 patients with periapical periapical admitted to our hospital from June 2015 to January 2017 were selected as the study subjects and were divided into the observation group and the control group,105 cases in each group.The observation group was treated by Vitapex paste for filling therapy,the control group was treated by traditional root canal paste.The postoperative pain and the total effective rate of 6 months were compared between the two groups.Results The pain degree of the observation group was significantly lower than that of the control group (P＜0.05).The total effective rate at 6 months in the observation group was significantly higher than that in the control group (P＜0.05).Conclusion Compared with the traditional root canal paste,filling with Vitapex paste can effectively improve the efficacy of patients with periapical periodontitis and significantly relieve pain. 2018 Vol. 25 (29): 97-99 [Abstract] ( 109 ) HTML (33 KB)  PDF  (0 KB)  ( 28 ) 100 Effect comparison of Minocycline Hydrochloride and Metronidazole Sticks in the treatment of periodontitis HE Ping Objective To compare the clinical efficacy of Minocycline Hydrochloride and Metronidazole Sticks in the treatment of periodontitis.Methods Twenty-two patients with chronic periodontitis admitted to our hospital from August 2016 to August 2017 were selected and divided into the observation group and the control group according to the random number table method,11 cases in each group.The observation group was treated with Minocycline Hydrochloride Ointment,and the control group was treated with Metronidazole Sticks.The periodontal clinical conditions,submicron microbiology,and the incidence rate of adverse drug reactions were observed before and after treatment in the two groups.Results there was no significant difference in the clinical and microbiological conditions between the two groups before treatment(P＞0.05),and the values of PLI,PD,GI,BOP,the number of bacilli and spirals after treatment at 7,14 d in the two groups were lower than those before treatment,and the number of staphylococci after treatment in the two groups after treatment at 7,14 d was higher than those before treatment(P＜0.05).There was no significant difference in clinical situation,microbiology and the incidence rate of adverse reactions between the two groups after treatment(P＞0.05).Conclusion Both Minocycline Hydrochloride and Metronidazole Sticks are effective drugs for periodontitis.They have safe and reliable characteristics,and the two drugs have similar efficacy. 2018 Vol. 25 (29): 100-102 [Abstract] ( 120 ) HTML (34 KB)  PDF  (0 KB)  ( 27 ) 103 Effect of local application of Ornidazole root canal paste in the treatment of periapical periodontitis of deciduous teeth GONG Da-dong Objective To explore the effect of ornidazole root canal paste in the treatment of periapical periodontitis of deciduous teeth.Methods A total of 102 cases of periapical periodontitis of deciduous teeth treated in our hospital from January 2017 to December 2017 were selected as the research object.According to the sequence of admission registration,all the patients were divided into the reference group(51 cases)and the study group(51 cases).The reference group applied the local application of Metronidazole root canal paste,and the study group was given Ornidazole root canal paste local treatment.The total effective rate,percussion score and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 96.08%,which was significantly higher than that of the reference group (38/51),with significant difference (P＜0.05).The percussion pain score of the study group was significantly lower than that of the reference group,with significant difference (P＜0.05).The incidence of adverse reactions of the study group was 3.92%,which was significantly lower than that of the reference group,and the difference was statistically significant(P＜0.05).Conclusion The treatment of Ornidazole root canal paste for the patients with periapical periodontitis of the deciduous teeth can improve the treatment efficiency,relieve the pain,reduce the incidence of adverse reactions,which have good effect,with high safety factor and good application value. 2018 Vol. 25 (29): 103-105 [Abstract] ( 129 ) HTML (33 KB)  PDF  (0 KB)  ( 35 ) 106 Clinical effect of pre-fabricated fiber post in oral prosthodontic treatment HE Jing-jing Objective To analyze the clinical application effect of pre-fabricated fiber post in the treatment of oral prostheses.Methods Sixty-eight patients with received oral prostheses in our hospital from January to December in 2017 were selected and divided into the observation group and the control group according to the different treatment mode,34 cases in each group.The control group was treated with plastic fiber post,and the observation group was treated with pre-fabricated fiber post.The efficacy,quality of life,and care satisfaction of the two groups were compared.Results The success rate of dental restoration in the observation group was higher than that of the control group,with significant difference(P＜0.05).The quality of life score in the observation group was significantly higher than that in the control group,with significant difference (P＜0.05).The satisfaction of the observation group was significantly higher than that of the control group,with significant difference (P＜0.05).Conclusion The oral rehabilitation of prefabricated fiber post in patients with oral prosthesis has a significant therapeutic effect,which can not only effectively improve the success rate of patients with restored teeth,but also improve the patient′s quality of life and satisfaction. 2018 Vol. 25 (29): 106-108 [Abstract] ( 122 ) HTML (34 KB)  PDF  (0 KB)  ( 22 ) 109 Clinical application effect of tinnitus retraining therapy in the treatment of tinnitus LUO Gao-qing;LIN Xi-kang;CAI Yan-fei;LI Xiao-rong Objective To study the clinical application effect of tinnitus retraining therapy in the treatment of tinnitus.Methods A total of 94 tinnitus patients who were admitted to our hospital from October 2016 to October 2017 were selected as the study subjects.According to odd-even grouping method,they were divided into the control group(47 cases)and the experimental group(47 cases).The control group was given drug therapy.The experimental group was given tinnitus retraining therapy on the basis of the control group.The therapeutic effects,quantifiable results of tinnitus irritability level,anxiety and depression scores were compared between the two groups.Results The total adaptation rate in the experimental group after treatment at 1,3,6 months was higher than that in the control group,with significant difference (P＜0.05).The quantifiable results of tinnitus irritability level in both groups after treatment were improved,the improvement rate in the experimental group after treatment was significantly better than that in the control group,with significant difference (P＜0.05).The anxiety scores and depression scores in both groups after treatment were improved,the improvement rate in the experimental group after treatment was significantly better than that in the control group,with significant difference (P＜0.05).Conclusion Tinnitus patients receiving tinnitus retraining therapy can significantly improve the patient′s clinical symptoms and promote the improvement of patient′s conditions.It is worthy of popularization and application. 2018 Vol. 25 (29): 109-111 [Abstract] ( 127 ) HTML (35 KB)  PDF  (0 KB)  ( 37 ) 112 Clinical value of Remifentanil combined with Propofol target controlled infusion in brain tumor surgery SHUAI Jun;MENG Hai-bin;GAO Zong-yan;JIN Si-li;ZHOU Biao Objective To explore the clinical effect of target controlled infusion of Remifentanil combined with Propofol in brain tumor surgery.Methods A total of 66 patients with brain tumors treated in the No 334 Hospital in Nanchang from July2016 to April 2018.The patients were divided into two groups according to the random number table method,33 cases in each group.The observation group was given Remifentanil compound Propofol target-controlled infusion,and the control group was given the Fentanyl compound Propofol,the operation time,anesthesia time,extubation time,blink time,recovery time,and mean arterial pressure and heart rate were observed and assessed.Results There was no significant difference in the operation time and anesthesia time between the two groups(P＞0.05）.The time of extubation,blinking time and recovery time in the observation group were all shorter than those in the control group (P<0.05）.There was no significant difference in the mean arterial pressure between the two groups at each time (P＞0.05）;Comparison of heart rate before induction in two group there was no significant difference (P＞0.05）;the heart rate was low after the induction in the observation group until the completion of the surgery.In the control group,the difference was statistically significant(P<0.05）.Conclusion Target-controlled infusion of remifentanil combined with Propofol has a high clinical value in patients with brain tumor surgery,and can ensure safety on the basis of exerting significant curative effect.It is worthy of application and promotion. 2018 Vol. 25 (29): 112-114 [Abstract] ( 133 ) HTML (35 KB)  PDF  (0 KB)  ( 30 ) 115 Comparison of Ketamine combined with different sedative drugs for intravenous anesthesia in children OUYANG Wei-dong;HU Hua-kun Objective To compare the clinical effects of Ketamine combined with Midazolam and Propofol in pediatric anesthesia.Methods A total of 72 cases of children′s elective operation at ASAⅠ～Ⅱ level in our hospital from January 2017 to January 2018 were randomly divided into Ketamine+Midazolam group and Ketamine+Propofol group according to the method of anesthesia,36 cases in each group.The effects of two anesthesia methods on the heart rate and mean arterial pressure of children,as well as anesthesia induction,awakening time and body movement were compared.Results The awakening time of children in Ketamine+Propofol group was significantly shorter than that of Ketamine+Midazolam group(P＜0.05）,and the number of body movement was significantly lesser than that of Ketamine+Midazolam group during the anesthesia(P＜0.05）.The heart rate of the children in the Ketamine+Midazolam group was lower than that before anaesthesia,and the MAP was significantly higher than that before anesthesia,and the differences were statistically significant(P＜0.05）,but the heart rate and the MAP of the Ketamine+Propofol group had no significant changes(P＞0.05）.The incidence of adverse reactions in Ketamine+Propofol group was 9.37%,which was significantly lower than that in Ketamine+Midazolam group of 18.75%,the difference was statistically significant(P＜0.05）.Conclusion Ketamine combined Propofol anesthesia has better clinical effect,and it has worthy of clinical promotion. 2018 Vol. 25 (29): 115-117 [Abstract] ( 117 ) HTML (35 KB)  PDF  (0 KB)  ( 36 ) 118 Clinical study of combined use of three drugs in the treatment of overlapping functional dyspepsia of diarrhea induced irritable bowel syndrome LIU Ning;RAO Jian-guo Objective To study the clinical effect of three drugs combined with diarrhea-predominant irritable bowel syndrome on functional dyspepsia.Methods Sixty patients with diarrhea-predominant irritable bowel syndrome with functional dyspepsia who were admitted to our hospital from September 2015 to September 2017 were selected as subjects and were randomly divided into two groups by lottery,with 30 cases in each group.Patients in the control group were given Montmorillonite Powder(3 g/time,3 times/d)+Domperidone(10 mg,3 times/d)pre-meal orally,patients in the observation group were given Mosapride(5 mg/time,3 times/d)on the above basis,oral 2 h after meal,4 weeks later,the clinical symptom scores,clinical efficacy,and adverse reactions of the two groups were compared before and after treatment.Results There was no statistically significant difference in clinical symptom scores between the two groups before treatment(P＞0.05).Clinical symptom scores in the observation group after treatment was(1.26±0.19)points,which was significantly lower than those in the control group of(4.53±0.36)points,the difference was statistically significant(P＜0.05).The total treatment efficiency in the observation group(96.67%)was significantly higher than the control group(70.00%),the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group(6.67%)was significantly lower than that in the control group(43.33%),the difference was statistically significant(P＜0.05).Conclusion The combination of three drugs in the treatment of diarrhea-predominant irritable bowel syndrome with functional dyspepsia can effectively improve the patient′s clinical discomfort,has significant efficacy,safety,and is worthy of promotion. 2018 Vol. 25 (29): 118-120 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 30 ) 121 Effect of Chlorphenamine Maleate combined with acupuncture point injection therapy of Vitamin B12Injection in atopic dermatitis 12Injection in atopic dermatitis[J]. 中国当代医药, 2018,25(29): 121-123')" href="#"> LIU Yu-ping;ZHANG Ling;SHEN Jin-di Objective To analyze the clinical efficacy of Chlorphenamine Maleate combined with acupuncture point injection therapy of Vitamin B12Injection in the treatment of allergic dermatitis.Methods Sixty-two patients with allergic dermatitis who came to our hospital from April 2017 to October 2017 were selected as subjects and divided into two groups according to the treatment method,31 cases in each group.Patients in the observation group were treated with Chlorpheniramine Maleate combined with acupuncture point injection therapy of Vitamin B12Injection,the patients in the control group were treated with intramuscular injection therapy of Chlorpheniramine Injection combined with Vitamin B12Injection.Clinical efficacy was compared between the two groups.Results In the observation group,the improvement rate of the patients′condition were higher than that of the control group after one day,three days,and seven days,the total treatment efficiency were higher than that of the control group,after the patient was discharged from the hospital,the recurrence rate in the observation group were lower than the control group after 10 days,30 days,and 60 days,the differences were statistically significant(P＜0.05).Conclusion The efficacy of Chlorphenamine Maleate combined with acupuncture point injection of Vitamin B12Injection in the treatment of allergic dermatitis is significant,it has a low recurrence rate,is worth promoting and applying. 2018 Vol. 25 (29): 121-123 [Abstract] ( 200 ) HTML (36 KB)  PDF  (0 KB)  ( 142 ) 124 Effect of Mosapride Citrate combined with Aluminum Phosphate on bile reflux gastritis SHEN Lin;LAN Jian Objective To explore the clinical effect of Mosapride Citrate combined with Aluminum Phosphate in the treatment of bile reflux gastritis.Methods A total of 86 cases of bile reflux gastritis treated in our hospital from January 14,2017 to January 20,2018 were selected as the subjects and divided into the control group (43 cases)and the observation group(43 cases)according to the random number method.The control group was treated with PPI combined with Mosapride Citrate,and the observation group was given the PPI and Mosapride Citrate combined with Aluminum Phosphate.The clinical total effective rate and clinical symptom score(anti acid,nausea,abdominal distention,heartburn,upper abdominal pain)and the incidence of adverse reactions(constipation,dry mouth,diarrhea)were compared between the two groups.Results The total effective rate of the observation group after treatment was 97.67%(42/43),which was higher than that of the control group of 72.09% (31/43),and the difference was statistically significant(P＜0.05).The clinical scores of the observation group(sour regurgitation of[0.56±0.12]points,nausea of[0.33±0.12]points,abdominal distension of[0.58±0.15]points,heartburn of[0.63±0.20]points and epigastric pain of[0.52±0.10]points)were lower than those in the control group(sour regurgitation of[1.63±0.36]points,nausea of[1.36±0.26]points,abdominal distention of[1.65±0.40]points,heartburn of[2.36±0.78]points and epigastric pain of[1.98±0.52]points),the differences were statistically significant(P＜0.05).The incidence of adverse reactions after treatment in the observation group was 2.33%(1/43),which was lower than that in the control group of 18.60%(8/43),and the difference was statistically significant(P＜0.05).Conclusion The combination of Mosapride Citrate and Aluminum Phosphate is of high clinical value in the treatment of bile reflux gastritis.It can reduce the incidence of adverse reactions on the basis of relieving clinical symptoms.It is worth applying and popularizing. 2018 Vol. 25 (29): 124-126 [Abstract] ( 130 ) HTML (34 KB)  PDF  (0 KB)  ( 30 ) 127 Effect observation of applying Glargine Insulin combined with oral drug in the treatment of type 2 diabetes HE Kai Objective To investigate the clinical effect of Glargine Insulin combined with oral drug in the treatment of type 2 diabetes.Methods A total of 126 patients with type 2 diabetes treated in our hospital were selected as subjects from January 2017 to December 2017.The patients were randomly divided into single group and combined group,63 patients in each group.Patients in the single group were treated by oral administration,patients in the combined group were treated with Glargine Insulin combined with oral drug.The blood glucose(FPG,2 h PG,HbA1c)before and after treatment,the total effective rate of treatment and the incidence of hypoglycemia were compared and analyzed between the patients of two groups.Results Before treatment,there was no significant difference in blood glucose between the two groups (P＞0.05),after treatment,the blood glucose of the combined group was lower than that of the single group(P＞0.05).After treatment,the total effective rate of the combined group was 92.06%,the total effective rate of the single group was 66.67%,the total effective rate of the combined group was higher than that of the control group,the difference was statistically significant(P＜0.05).The incidence of hypoglycemia in the combined group was 3.17%,and the incidence of hypoglycemia in the single group was 14.29%,the incidence of hypoglycemia in the combined group was lower than that of the control group,and the difference was statistically significant(P＞0.05).Conclusion The clinical effect of insulin glargine combined with oral medicine in the treatment of type 2 diabetes is ideal.It is effective to control the blood sugar within the normal range and reduce the incidence of hypoglycemia.It is worth popularizing and using in clinical practice. 2018 Vol. 25 (29): 127-130 [Abstract] ( 121 ) HTML (39 KB)  PDF  (0 KB)  ( 23 ) 131 Clinical effect of traditional Chinese medicine bath combined with Levofloxacin Injection and Glucocorticoid therapy in the treatment of acute epididymitis YIN Wei-qiang;XIE Hui-qin;WANG Xiu-di;ZHOU Jun-hong;TANG Yan-quan;LIAO Zhi-jian Objective To investigate the clinical effect of traditional Chinese medicine bath combined with Levofloxacin Injection and Glucocorticoid therapy in the treatment of acute epididymitis.Methods A total of 64 acute epididymitis patients with damp heat and blood stasis syndrome were selected as objects treated in our hospital from December 2016 to December 2017.They were divided into treatment group and control group according to the random number table method,with 32 cases in each group.Both groups were treated with Levofloxacin Injection in the first 7 d,Dexamethasone Sodium Phosphate Injections were also used in the first 3 d,and the treatment schemes were changed to Levofloxacin Hydrochloride Capsules orally after 7 d.The total course was 14 d.In addition,traditional Chinese medicine bath was applied to the treatment group once a day for 14 d.The clinical efficacy,scrotal pain scores and adverse events were compared between two groups.Results The total effective rate of the treatment group was higher than that of the control group,and the difference was significant(P＜0.05).There was no significant difference in the scrotal pain scores before treatment between two groups (P＞0.05).The scrotal pain scores after treatment in two groups were significantly lower than those before treatment,and the differences were significant(P＜0.01).The scrotal pain scores after treatment in the treatment group were lower than those in the control group,and the difference was significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion Traditional Chinese medicine bath can significantly improve the clinical efficacy of combination therapy in the treatment of acute epididymitis,which can reduce the pain of patients,and its safety is good. 2018 Vol. 25 (29): 131-133转137 [Abstract] ( 133 ) HTML (42 KB)  PDF  (0 KB)  ( 32 ) 134 Application effect of traditional Chinese medicine syndrome differentiation combined with minimally invasive hip-preserving therapy in the treatment of femoral head osteonecrosis XU Fa-ming;ZHANG Yong-xing Objective To investigate the application effect of traditional Chinese medicine(TCM)syndrome differentiation combined with minimally invasive hip-preserving therapy in the treatment of femoral head osteonecrosis.Methods A total of 138 patients with femoral head osteonecrosis treated in our hospital from January 2015 to March 2018 were selected as objects and they were randomly divided into the control group and the test group,with 69 cases in each group.The control group was treated with the minimally invasive hip-preserving therapy,and the test group was given syndrome differential treatment on the basis of the control group.The clinical efficacy,hospital-related indicators,life quality scores,and hip function (Harris)scores were compared between two groups.Results The total clinical effective rate in the test group was 94.2%,which was higher than that in the control group (81.5%),and the difference was statistically significant(P＜0.05).The hospitalization days and healing time in the test group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the life quality scores before treatment between two groups(P＞0.05).The life quality scores after 4,8 weeks of treatment in two groups were higher than those before treatment,and the differences were statistically significant(P＜0.05).The life quality scores after 4,8 weeks of treatment in the test group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the Harris scores before treatment between two groups(P＞0.05).The Harris scores after 4,8 weeks of treatment in two groups were higher than those before treatment,and the differences were statistically significant(P＜0.05).The Harris scores after 4,8 weeks of treat-ment in the test group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The TCM syndrome differential treatment combined with minimally invasive hip-preserving therapy can better increase the effective rate and quality of life,promote the fast recovery and improve the hip joint function,which is worthy of clinical selection. 2018 Vol. 25 (29): 134-137 [Abstract] ( 118 ) HTML (41 KB)  PDF  (0 KB)  ( 23 ) 138 Effect of Banxia Baizhu Tianma Decoction combined with Edaravone in the treatment of acute ischemic stroke HUANG Deng-tang Objective To investigate the effect of Banxia Baizhu Tianma Decoction combined with Edaravone in the treatment of acute ischemic stroke.Methods A total of 100 patients with acute ischemic stroke admitted to our hospital from May 2015 to May 2017 were selected as objects and randomly divided into the control group (50 cases)and the study group (50 cases).The control group was treated with Edaravone,while the study group was treated with Banxia Baizhu Tianma Decoction on the basis of the control group.The clinical efficacy,NIH stroke scale(NIHSS)scores and activity of daily living scale(ADL)scores before and after treatment in two groups were compared.Results The total effective rate of treatment in the study group (98.00%)was significantly higher than that in the control group (82.00%),and the difference was statistically significant(P＜0.05).There were no significant difference in NIHSS scores and ADL scores before treatment between two groups(P＞0.05).The NIHSS scores after treatment in the study group and control group ([10.65±1.55]points,[17.60±1.78]points)were respectively lower than those before treatment([25.02±2.60]points,[25.05±2.55]points),ADL scores([40.10±12.12]points,[36.55±11.95]points)after treatment were respectively higher than those before treatment([17.45±1.73]points,[17.40±1.78]points),and the differences were statistically significant(P＜0.05).The NIHSS scores after treatment in the study group were lower than those in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in ADL scores after treatment between the study group and the control group (P＞0.05).Conclusion Banxia Baizhu Tianma Decoction combined with Edaravone in the treatment of acute ischemic stroke is effective,and the symptoms of the disease after treatment are improved more significantly. 2018 Vol. 25 (29): 138-140 [Abstract] ( 123 ) HTML (35 KB)  PDF  (0 KB)  ( 26 ) 141 Analysis and countermeasures of drug bidding management in our hospital SUN Chuang-bin;XU Yuan-yuan;TAN Lei Drug bidding refers to a kind of transaction that the bidding procurement agency sends out the notice of drug bidding,explains the name,specification,quantity and other conditions of the purchase,and invites enterprises to bid in a prescribed time and place in accordance with a certain procedure.The management of drug bidding and purchasing in our hospital mainly includes network purchasing,emergency purchase and temporary purchase,which has achieved good results in the process of implementation,but there are also many problems in practice.This paper analyzes the main problems arising from the procurement of drugs from the hospital,the winning enterprises and the government,and discusses the countermeasures to solve the problems. 2018 Vol. 25 (29): 141-143 [Abstract] ( 131 ) HTML (36 KB)  PDF  (0 KB)  ( 20 ) 144 Management effectiveness of antibacterial agents in the prevention of perioperative period of clean incision XIA Chang-liang Objective To analyze the management effectiveness of antibacterial agents in the prevention of perioperative period of clean incision.Methods A total of 1863 patients who underwent clean incision surgery in our hospital from October 2014 to September 2016 were selected as subjects.Altogether 902 patients before the intervention from October 2014 to September 2015 were selected as the control group,and 961 patients who underwent comprehensive intervention from October 2015 to September 2016 were selected as the study group.The clinical data of comprehensive intervention to strengthen the use of antibacterial agents before and after management were compared and analyzed to explore the management effectiveness.Results The rate of prophylactic antibacterial use in the study group was 27.26%(262/961),which was lower than that in the control group(53.88%[486/902]),and the difference was statistically significant(P＜0.05).The rate of drug use within 30 min to 1 h before surgery in the study group was 97.71%,which was higher than that in the control group(71.19%),and the difference was statistically significant(P＜0.05).The incidence of prophylactic antibacterial use lower than 24 h in the study group was 85.11%,which was higher than that in the control group(80.25%),and the difference was statistically significant(P＜0.05).The average time of prophylactic antibacterial use in the study group was(1.47±0.23)d,which was shorter than that in the control group([5.18±1.45]d),and the difference was statistically significant(P＜0.05).For the selection of varieties of antibacterial drugs,the past empirical application of restricted antibacterial drugs such as Cefoxitin,Cefathiamidine and Cefotiam,have been changed to the standard application of the first and second generation of non-restricted Cephalosporins such as Cefazolin and Cefuroxime.Conclusion The comprehensive intervention management for prophylactic antibacterial use in clean incisions during perioperative period is beneficial for standardized prophylactic antibacterial use.This management mode needs to be extensively promoted and applied. 2018 Vol. 25 (29): 144-146 [Abstract] ( 116 ) HTML (35 KB)  PDF  (0 KB)  ( 29 ) 147 Application effect of operating room detail nursing intervention on laparoscopic surgery in elderly patients LI Xin-fang Objective To investigate the application effect of operating room detail nursing intervention on elderly patients undergone surgery.Methods From February 2015 to April 2017,80 patients performed with laparoscopic surgery in our hospital were selected for analysis.All patients were divided into reference group and study group by a random lottery,40 cases in each group.In the reference group,routine nursing intervention was used,while in the study group,detail nursing intervention in the operating room was adopted.The patient′s satisfaction and pain,anxiety and depression scores of the two groups were assessed.Results The satisfaction of the study group was higher than that of the reference group with a significant difference (P<0.05）.The pain score,anxiety and depression scores of the study group were lower than those in the reference group with statistical significance (P<0.05）.Conclusion The implementation of operating room detail nursing intervention in elderly patients can effectively improve patient′s satisfaction,relieve pain and reduce anxiety and depression scores,which is worthy of clinical promotion. 2018 Vol. 25 (29): 147-149 [Abstract] ( 120 ) HTML (32 KB)  PDF  (0 KB)  ( 26 ) 150 Effect of psychological intervention measures on the patients undergoing laparoscopic surgery for infertility WAN Xiao-qin Objective To explore the effect of psychological intervention on laparoscopic treatment of infertility and provide guidance for clinical practice.Methods From December 2014 to December 2016,58 patients with infertility in our hospital were selected as the observation subjects.Laparoscopic treatment was performed in 58 patients.The random number table method was used to divide 58 patients into routine group (n=29,receiving routine nursing care)and psychological group (n=29,receiving routine nursing care+psychological nursing care).One year follow-up visit was performed to compare the psychological status scores,satisfaction and conception rate between the two group.Results The scores of post-intervention psychological status in the psychological group was(19.24±2.87)points,compared with the conventional group of(25.62±3.21)points,the difference was statistically significant(P<0.05）;the degree of satisfaction (96.55%)and conception rate (93.10%)in the psychological group were significantly higher than those in the conventional group(72.41%,68.97%),and the differences were statistically significant(P<0.05）.Conclusion The effect of psychological intervention on the patients undergoing laparoscopic treatment of infertility is better,which can effectively improve negative emotions of patients. 2018 Vol. 25 (29): 150-152 [Abstract] ( 118 ) HTML (34 KB)  PDF  (0 KB)  ( 20 ) 153 The role of prenatal care in improving the outcome of vaginal delivery in women with scarred uterus ZHOU Hong;ZENG Jie-lian;HE Xiang-lian;XIE Chun-yan Objective To study the effect of prenatal care on improving the outcome of vaginal delivery in women with scarred uterus.Methods Sixty puerperae with scarred uterus via vaginal delivery in Maternal and Child Health Care Hospital of Xinfeng County from January to August 2017 were selected as the study subjects.By a random number table method,they were equally divided into control group and observation group.In the control group,routine nursing mode was used,while in the observation group,prenatal comprehensive nursing intervention was adopted.The scores of anxiety and depression,nursing satisfaction score,maternal delivery,maternal pregnancy outcome,2 h amount of bleeding,24 h amount of bleeding and the incidence of complications were compared.Results The anxiety and depression scores of the observation group were lower than those of the control group,the nursing satisfaction score was higher than that of the control group,the natural delivery rate was higher than that of the control group,the normal rate of vital signs in pregnant women and fetus was higher than that of the control group,the 2 h and 24 h amount of bleeding were both lesser than those in the control group,in the observation group,the incidence of complications was lower than that of the control group,the differences mentioned above all displayed statistical significance(P<0.05）.Conclusion Prenatal comprehensive nursing intervention can effectively improve the adverse psychological status of women with scar uterus before delivery,shorten the labor process,reduce the cesarean section rate,the risk of maternal delivery,and the postpartum hemorrhage and complications,which meets the patient′s care and has a high clinical promotion value. 2018 Vol. 25 (29): 153-155 [Abstract] ( 127 ) HTML (37 KB)  PDF  (0 KB)  ( 23 ) 156 Application effect of systematic nursing in children with intussusception treated by hydrostatic enema reduction JIANG Li Objective To explore the application effect of systematic nursing in children with intussusception treated by hydrostatic enema reduction.Methods A total of 48 cases of children with intussusception treated by color Doppler ultrasound guided water pressure enema treatment from June 2014 to June 2017 were randomly divided into the observation group (n=24)and the control group (n=24).Two groups of children were treated with color Doppler ultrasound guided water enema reduction treatment.The control group was received routine clinical nursing,and the observation group was implemented systematic nursing service on this basis.Results All time of treatment,length of stay and postoperative anal exhaust time in the observation group were shorter than those in the control group,the differences were statistically significant(P＜0.05）.The blood CRP level was higher that that in the control group,fecal leukocytosis was more than that in the control group,fever and diarrhea were significantly lower in the observation group than those in the control group(P＜0.05）.The recurrence rate of the 24 h in the observation group was lower than that in the control group(P＜0.05）.There was no significant difference between the two groups in the success rate of enema reduction(P＞0.05）.Conclusion Systematic nursing can improve the treatment of children with intussusception by water pressure enema reduction,reduce complications and recurrence rate,and reduce family financial burden. 2018 Vol. 25 (29): 156-158转165 [Abstract] ( 111 ) HTML (38 KB)  PDF  (0 KB)  ( 27 ) 159 Comparison of application effect between venous indwelling needle and scalp steel needle in outpatient department of pediatrics ZENG Jie-lian;ZHANG Tian-shu;YIN Qiu-hong objective To compare the effect of intravenous indwelling needle and scalp needle in pediatric clinic.Methods 102 cases of children admitted to our hospital from June 2016 to May 2017 were included in the study.They were randomly divided into control group and experimental group,51 cases in each group.Children in the control group were treated with disposable scalp needles for infusion.The experimental group of children Intravenous indwelling needles were used for infusion.The incidence of adverse events,puncture success rate,and care satisfaction were compared between the two groups.Results The incidence of adverse events in the experimental group was lower than that in the control group,and the satisfaction rate of nursing and the success rate of one puncture were higher than those in the control group,and the differences were statistically significant(P<0.05）.Conclusion The use of intravenous indwelling needle can reduce the number of puncture,reduce the pain of children,and reduce the occurrence of drug fluid extravasation and detubation. 2018 Vol. 25 (29): 159-161 [Abstract] ( 116 ) HTML (34 KB)  PDF  (0 KB)  ( 28 ) 162 Effect of control and prevention related nursing on urinary tract retrograde infection in elderly patients with indwelling catheter LIU Dong-ying;LIN Hua Objective To study the effect of control and prevention related nursing on urinary tract retrograde infection in elderly patients with indwelling catheter.Methods A total of 160 elderly patients who underwent indwelling catheters in our hospital from October 2016 to October 2017 were selected as subjects.According to the different methods of treatment for patients,they were equally divided into observation group and control group.In the observation group,relevant care for control and prevention was adopted,while in the control group,general routine care was used.The number of urinary tract retrograde infections,patient′s satisfaction on nursing,and care quality were used as the evaluation basis for the control and prevention effects.Results The survey showed that the quality of care and the patient′s satisfaction on nursing in the observation group were significantly higher than those of the control group (P<0.05）.The incidence of urinary tract retrograde infection in the observation group was lower than that in the control group with a statistical difference(P<0.05）.Conclusion The control and prevention of urinary tract retrograde infection in elderly patients with indwelling catheters is very effective.For elderly patients with indwelling catheters,the impeccable control and prevention system for retrograde urinary tract infections can be used to strengthen the delicate nursing on patients with indwelling catheters,so as to effectively reduce or even avoid the urinary tract retrograde infection caused by indwelling catheters. 2018 Vol. 25 (29): 162-165 [Abstract] ( 125 ) HTML (40 KB)  PDF  (0 KB)  ( 24 ) 166 Application of central suction device in nursing of patients with intestinal fistula after negative pressure drainage after intestinal anastomosis JIANG Ming-yuan;JIANG Hui;LI Han-hua Objective To analyze the effect of central suction device in nursing of patients with intestinal fistula after negative pressure drainage after intestinal anastomosis.Methods Eighty patients with intestinal fistula who underwent enteroanastomosis from August 2015 to July 2017 were selected and grouped according to a single and double number of visits.With single number were observed group,and with double number were control group,40 cases in each group.The control group was drained by drainage tube,and the observation group was received continuous negative pressure drainage with central suction device.The recovery time,incidence of wound infection,frequency of dressing change and quality of life before and after treatment were compared between the two groups.Results The exhaust time,extubation time,healing time and length of stay in the observation group were significantly shorter than those in the control group(P<0.05）.The incidence of incision infection in the observation group was lower than that in the control group(P<0.05）.There was no significant difference in the scores of social function,psychological function,physical function and material life between the two groups before nursing(P＞0.05）.The scores of social function,psychological function and physical function of the observation group were significantly higher than those of the control group after nursing，the differences were statistically significant(P<0.05).There was no significant difference in the scores of material life between the two groups after nursing(P＞0.05）.Conclusion The central suction device can effectively shorten the recovery time and reduce the infection and improve the quality of life in the nursing of intestinal fistula negative pressure drainage after intestinal anastomosis. 2018 Vol. 25 (29): 166-168 [Abstract] ( 108 ) HTML (35 KB)  PDF  (0 KB)  ( 22 ) 169 Effect of path based exercise therapy on pneumoperitoneum complications and quality of life after gynecologic laparoscopic hysterectomy ZENG Li-qin;XIONG Hua Objective To explore the effect of path based exercise therapy on pneumoperitoneum complications and quality of life after gynecologic laparoscopic hysterectomy.Methods A total of 80 cases of laparoscopic hysterectomy in our hospital from December 2015 to December 2017 were selected and randomly divided into the observation group and the control group,40 cases in each group.The control group was given routine postoperative care.The observation group was given the path exercise therapy on the basis of the control group.The postoperative pneumoperitoneum complications(shoulder pain and subcutaneous)occurrence and quality of life of emphysema and hypercapnia were evaluated.Results The total incidence of shoulder pain,subcutaneous emphysema and complications after operation in the observation group were significantly lower than those of the control group(P<0.05）.Compared with the intervention,the two groups were significantly changed in the environment,psychological,physiological,social relations,general feeling and total score,and the observation group intervened.The above scores were significantly higher than those of the control group,and the differences were statistically significant(P<0.05）.Conclusion It is helpful to reduce the postoperative complications of pneumoperitoneum and improve the quality of life in patients with gynecologic laparoscopic hysterectomy,which is worthy of clinical application. 2018 Vol. 25 (29): 169-171 [Abstract] ( 133 ) HTML (35 KB)  PDF  (0 KB)  ( 26 ) 172 Application result high quality nursing in patients with senile cerebral infarction LAI Shi-di;CHEN Hua-qing Objective To study the quality of nursing service mode in the application of senile cerebral infarction care effect.Methods A total of 82 cases of senile cerebral infarction hospitalized in our hospital from January 2015 to October 2017,were divided into control group and observation group according to random number table method,41 cases in each group.The control group was given routine nursing,the observation group was based on this,was given high quality nursing service,the two groups before and after the simple mental state examination scale(MMSE),national inistitute of health strolce scale(NIHSS),ADL and quality of life score were compared,and the nursing satisfaction of the two groups was compared.Results Before nursing,there was no significant difference in the scores of ADL and NIHSS between the two groups(P＞0.05）.After nursing,the ADL score and MMSE score of the observation group were higher than those of the control group (P<0.05）,and the NIHSS scores were lower than those of the control group (P<0.05）.The quality of life,health,mental support,activity）scores and total scores in the observation group were higher than those in the control group(P<0.05）.The nursing satisfaction of the observation group(97.56%)was higher than that of the control group(82.93%),and the differences were statistically significant(χ2=8.65,P<0.05).Conclusion According to the elderly patients with cerebral infarction,the high quality nursing service model can significantly improve their daily life,cognitive and neurological ability,improve the quality of life and nursing satisfaction,and the clinical application is of high value. 2018 Vol. 25 (29): 172-174 [Abstract] ( 111 ) HTML (34 KB)  PDF  (0 KB)  ( 26 ) 175 Application effect of maternal and infant bedside nursing in maternity nursing WANG Xiao-yang;LUO Wei;LI You-cong;CHEN Yan-qun;CHEN Gui-hua Objective To explore the effect of application of maternal and infant bedside nursing in promotion of maternal nursing skills and their nursing satisfaction.Methods A retrospective analysis was performed on 50 pregnant women who were hospitalized in Department of Neonatology of Baoan District Hospital of Traditional Chinese Medicine in Shenzhen from September 2017 to March 2018.All the pregnant women were divided into the experiment group and control group according to the different nursing methods,25 cases in each group.In the experiment group,the maternal and infant bedside nursing methods was adopted;while,the control group was treated with traditional nursing methods.The nursing satisfaction and the mastery degree of neonatal nursing skills of all the cases were investigated and compared at discharge.Results The nursing satisfaction of the experiment group was higher than that of the control group,with statistically significant difference(P＜0.05）.The scores of hip nursing,umbilical nursing,infant bathing and swimming and touch-related nursing of experiment group were significantly higher than those of control group,with statistically significant difference(P＜0.05）.Conclusion Maternal and infant bedside nursing can effectively promote maternal mastery of neonatal nursing skills and significantly improve their satisfaction with nursing,which is worthy of clinical application. 2018 Vol. 25 (29): 175-177 [Abstract] ( 127 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 178 Effect of emotional nursing in rehabilitation of patients with cervical spondylosis CHENG Xiao-hong;QIAN Cui-yu Objective To study the role of emotional nursing in the rehabilitation of patients with cervical spondylosis.Methods One hundred patients with cervical spondylosis who were treated in our hospital from April 2016 to April 2018 were selected and the patients were divided into two groups according to the different nursing methods,50 cases in each group.Patients in the controi group were received routine care,patients in the experimental group were received emotional care,and the anxiety scores,depression scores,pain scores,nursing satisfaction,and clinical treatment effects of the two groups were compared.Results After the nursing,the anxiety scores of the experimental group,the depression score,and the pain score.were lower than those of the control group,the differences were significant(P<0.05）;the quality of the patients in the experimental group compared with the control group,the difference between the groups was significant(P<0.05）;the total effective rate of the experimental group was 96.00%,higher than that in the control group,difference was statistically significantly (P<0.05）.Conclusion Patients with cervical spondylosis receiving emotional care during rehabilitation treatment can promote the improvement of patients'condition and it is worthy of promotion and application. 2018 Vol. 25 (29): 178-180 [Abstract] ( 118 ) HTML (35 KB)  PDF  (0 KB)  ( 24 ) 181 Application effect of humanistic care in the recovery of schizophrenia PAN Xiao-zhen Objective To explore the application of humanistic care in the recovery of schizophrenia.Methods A total of 76 patients with convalescent schizophrenia who were admitted to our hospital from January to December 2017 were selected.The patients were divided into observation group and control group according to random number table methods,38 cases in each group.The observation group was treated with humanistic care and the control group was given routine nursing.The care effects of the two groups of patients were compared.Results The scores of somatization,interpersonal relationship,obsessive-compulsive,depression,anxiety,horror,paranoid,hostile,and psychoticism were lower in the observation group than in the control group,the BPRS score of(22.18±2.46)points was lower than the control group of(33.10±2.54)points,household work,social skills,life function,interest and hobbies were significantly better than the control group,and the data were statistically significant(P<0.05).Conclusion The application of humanistic care in the rehabilitation of schizophrenia in the recovery period can improve the mental status of the patients as soon as possible,and the effect is significant. 2018 Vol. 25 (29): 181-183 [Abstract] ( 109 ) HTML (33 KB)  PDF  (0 KB)  ( 34 ) 184 Effect of prenatal high quality nursing on psychological state and sleep quality of high-risk pregnant women XIAO Hui;SUN Yun-ling;CHEN Yu-zhen Objective To study the effect of prenatal high quality nursing on high-risk pregnant women′s psychological state and sleep quality.Methods A total of 60 high-risk pregnant women who were admitted to our hospital from March 2016 to April 2017 were selected.According to the order of admission,they were divided into study group and control group,30 cases in each group.The control group was given routine nursing intervention,and the study group was given prenatal high quality nursing on the basis of routine nursing in the control group.The two groups of pregnant women′s self-rating depression scale(SDS),self-rating anxiety scale(SAS)and Pittsburgh sleep scale were compared to evaluate the mental state and sleep quality of the two groups of pregnant women.Results The SAS score of the study group was(51.24±4.6)points and SDS score was(50.80±4.38)points.The SAS score of the control group was(58.53±5.58)score and SDS score was (57.83±5.32)points.The SAS score and the SDS score of the study group were significantly lower than those in the control group (P<0.05）.The sleep time score of the study group was (1.4±0.2）points,sleep efficiency score was(1.5±0.4)points,the sleep time score of the control group was(1.9±0.3)points,and sleep efficiency score was (2.2±0.3)points.The sleep time score and sleep efficiency score of the study group were significantly lower than that of the control group,the differences were statistically significant(P<0.05）.Conclusion Prenatal high quality nursing for high-risk pregnant women can improve the psychological state and sleep quality of pregnant women,and is worthy of clinical application. 2018 Vol. 25 (29): 184-186 [Abstract] ( 124 ) HTML (35 KB)  PDF  (0 KB)  ( 31 ) 187 Effect of comprehensive nursing intervention on nausea and vomiting and the quality of life of patients after chemotherapy of hematological diseases FENG Gui-juan;CAI Yu;LUO Jin-lian;ZENG Xiao-qing Objective To study the effect of comprehensive nursing intervention on nausea and vomiting and their quality of life in patients with hematopathy after chemotherapy.Methods 84 patients with hematologic chemotherapy treated in our hospital from April 2014 to October 2017 were selected and divided into control group and observation group by randomized sequential method,42 cases in each group.The control group was used routine nursing intervention and the observation group was used comprehensive nursing intervention.The incidence of adverse reactions during the patient care was recorded and the nursing effect was evaluated by the nursing satisfaction score,sleep quality score,pain score and quality of life score.Results The incidence of adverse reactions in the observation group (2.38%)was lower than that in the control group(28.57%),the difference was statistically significant(P<0.05）.Before nursing intervention,the nursing satisfaction score,sleep quality score,pain score and quality of life score between two groups were compared,the difference had no statistical significance (P＞0.05）,after nursing intervention,the quality of life score of the observation group was higher than that of the control group,and the pain score and sleep quality score were lower than those of the control group,which were statistically significant(P<0.05）.Conclusion Comprehensive nursing intervention can effectively improve the prognosis,reduce adverse reactions and pain,and improve sleep quality and quality of life in patients with hematological diseases. 2018 Vol. 25 (29): 187-189 [Abstract] ( 113 ) HTML (35 KB)  PDF  (0 KB)  ( 30 ) 190 Application effect of family-based complementary health education nursing in children with fever TAN Cai-yu Objective To explore the application effect of family-based complementary health education nursing in children with fever.Methods From February 2017 to February 2018,86 children with fever in our hospital were enrolled in our hospital.The childrens were divided into two groups by odd/even number,43 cases in each grouo.Pediatric childrens in the control group were received routine nursing intervention,while in the experimental group,they were provided with family-based complementary health education nursing intervention.Results The mastery of the children in the experimental group on the correct treatment of pediatric fever,treatment of fever at preliminary stage,rational selection of antipyretic drugs,reasonable measures to bring down body temperature,and body temperature measurement were significantly higher than those of the control group (P<0.05）.In the experimental group,the scores of nursing quality such as service attitude,ward environment,management normativeness,timely service,comprehensive quality and total score were higher than those of the control group,the differences were the statistically significant(P<0.05）.Conclusion Children with fever and their families provided with family-based on complementary health education as a nursing intervention can promote the treatment and nursing methods of children′s families to master the disease and improve pediatric therapeutic effect children,which is worthy of popularization and application. 2018 Vol. 25 (29): 190-192 [Abstract] ( 107 ) HTML (33 KB)  PDF  (0 KB)  ( 21 ) 193 Application effect of comprehensive nursing intervention in children with febrile convulsion nursing SUN Rong;WU Qun-fang Objective To analyze the effect of comprehensive nursing intervention on mental state and clinical effect of children with febrile convulsion.MethodsFrom February 2015 to August 2017,60 children with febrile convulsion treated in our hospital were selected and randomly divided into the control group (n=30)and experimental group (n=30).Routine nursing was given in the reference group and comprehensive nursing intervention was given in the experimental group.The nursing effect of the two groups was compared.Results The antipyretic time,convulsion disappearance time and hospitalization time in the experimental group were significantly shorter than those in the control group(P<0.05).The scores of SAS and SDS in the two groups were significantly reduced than those before treatment(P<0.05),but the SAS score and SDS score in the experimental group was significantly lower than that in the control group (P<0.05).The total satisfaction of the patients in the experimental group was 93.33%,which was significantly higher than that of the control group(70.00%),the differencesereas statistically significant(P<0.05).Conclusion The comprehensive nursing intervention for children with febrile convulsion can effectively improve the psychological state of the family members of the children,shorten the time of hospitalization,the time of disappearance of convulsion and the antipyretic effect.Time,clinical effect is remarkable,worth clinical popularizing use. 2018 Vol. 25 (29): 193-195 [Abstract] ( 103 ) HTML (33 KB)  PDF  (0 KB)  ( 19 ) 196 Application effect of comprehensive nursing in patients with postoperative radiotherapy for breast cancer LAI Xiao-ming;LIN Yu-Sheng;ZENG Ying-ting Objective To investigate the effect of comprehensive nursing in postoperative radiotherapy for breast cancer patients.Methods Sixty female breast cancer postoperative radiotherapy patients who treated in our hospital from January 2015 to January 2018 were selected as study subjects.According to the nursing methods,they were divided into control group and experimental group,30 cases in each group.The patients in the control group were treated with routine care.The patients in the experimental group were given on this basis with comprehensive nursing interventions.The quality of life scores and nursing satisfaction were compared between the two groups.Results The quality of life and nursing satisfaction in the experimental group were significantly higher than that in the control group,the differences were statistically significant(P<0.05）.Conclusion Compared with routine care,clinical nursing interventions can better improve the quality of life scores of patients,and thus improve the patients′care satisfaction so it is worth being promoted. 2018 Vol. 25 (29): 196-198 [Abstract] ( 125 ) HTML (33 KB)  PDF  (0 KB)  ( 25 ) 199 Application effect of comfortable nursing in hematological diseases nursing XIA Yan-ling;ZHANG Chun-xia;YI Jia;LI Li;WANG Wen-ting Objective Analyze the application effect of comfortable care in hematology care.Methods A totla of 78 patients with hematological malignancies treated in our hospital from January to December 2017 were selected as research subjects,the patients were randomly divided into two groups by lottery,39 cases in each group.The study group was performed comfort nursing and the control group was received routine nursing,the anxiety and depression scores,comfort scores and nursing satisfaction were compared between the two groups.Results After the intervention,the anxiety and depression scores of the study group were lower than those of the control group,comfort scores and nursing satisfaction were higher than those of the control group,the differences were statistically significant(P<0.05）.ConclusionApplying comfort care to hematologic diseases improves negative emotions,improve comfort and care satisfaction,worthy of clinical application. 2018 Vol. 25 (29): 199-201 [Abstract] ( 115 ) HTML (35 KB)  PDF  (0 KB)  ( 32 ) 202 Study on nursing management of thrombolysis time window in patients with ischemic stroke XIA Lian-xiang;ZHONG Yuan-mei;SHENG Xiao-wei;TU Fu-tang Objective To investigate the effect of time window nursing in patients with ischemic stroke.Methods A total of 70 patients with acute ischemic stroke who were treated in our hospital from January 2017 to April 2018 were selected as research subjects.They were randomly divided into two groups,35 patients cases in each group.In control group,general care was used,while the time window management was adopted in the time window management group.The neurological deficits NIH Stroke Scale(NIHSS)score before and after thrombolysis and Glasgow Coma Scale(GCS)for prognosis evaluation,quality of life (QOL)score,and disability,fatality,and incidence of complications were compared between the two groups.Results In the time window management group,there was no significant difference in the NIHSS score 2-hour or 24-hour after thrombolysis compared with those in the control group(t=0.2877,1.4881;P＞0.05）,but 1-week and 3-month after thrombolysis,the NIHSS score was lower than those in the control group,with statistical differences (t=5.1730,12.6 480;P＜0.05）.The improvement of GCS and QOL scores in the time window management group was greater than that in the control group with statistical significance (t=17.5338,2.7765;P＜0.05）.The incidence of complications in the time window management group was lower than that in the control group with a significant difference (χ2=4.629,P＜0.05）.Conclusion Time window nursing management can improve the neurological function of patients with ischemic stroke,promote good prognosis,ameliorate patients′QOL,and have low fatality and disability rates,which is worthy of clinical application. 2018 Vol. 25 (29): 202-205 [Abstract] ( 125 ) HTML (43 KB)  PDF  (0 KB)  ( 26 ) 206 Application effect of Zero defect theory in operation room heart surgery nursing LI Shu-Hong;SUN Ting-ting Objective To explore the application effect of surgical nursing mode in cardiac surgery in the operating room under the zero defect theory.Methods A total of 55 patients with cardiac surgery in our hospital from January 2016 to December 2017 were selected as the study subjects,and were divided into the observation group (n=28)and the control group (n=27)according to the order of admission.The control group was received conventional surgical nursing intervention and the observation group was received surgical nursing intervention under the theory of zero defect.The two groups were compared for intraoperative and postoperative conditions,the occurrence of nursing defects and the nursing quality scores.Results The blood loss in the observation group was lesser than that in the control group,and the length of the operation and days of hospital stay were shorter than those in the control group.The differences were statistically significant(P<0.05）.The incidence of nursing defects in the observation group was 3.57%(1/28),which was lower than that of the control group 25.93%(7/27),with statistically significant differences(P<0.05）.The nursing quality score of the observation group was higher than that of the control group,with statistically significant differences(P<0.05）.Conclusion The application of zero defect theory in cardiac surgery nursing in the operating room can significantly improve the surgical condition,reduce the defect of nursing and improve the quality of nursing. 2018 Vol. 25 (29): 206-208 [Abstract] ( 101 ) HTML (34 KB)  PDF  (0 KB)  ( 21 ) 209 Effect of targeted nursing in the nursing of bronchopneumonia in children YANG Li-hong Objective To study the clinical nursing value of targeted nursing for children with bronchopneumonia.Methods According to the order of hospitalization,60 children with bronchial pneumonia in our hospital from May 2014 to July 2017 were divided into control group and observation group,30 cases in each group.The control group was given standardized nursing intervention and the observation group was targeted nursing intervention respectively,and the effects of two groups of nursing intervention were compared.Results The clinical total effective rate of the observation group was significantly higher than that of the control group (P<0.05）,and the clinical symptoms,the recovery time of the signs and the time of hospitalization were significantly shorter in the observation group,the differences were the statistically significant(P<0.05）.Conclusion The application of targeted nursing in the nursing of bronchopneumonia in children has a prominent clinical effect,improving the total clinical efficiency,promoting the disappearance of the symptoms,and promoting the application value. 2018 Vol. 25 (29): 209-211 [Abstract] ( 128 ) HTML (32 KB)  PDF  (0 KB)  ( 22 ) 212 Application effect of comfortable nursing in burn patients LUO Yan Objective To explore the effect of comfort nursing on pain score and stress state during burn wound dressing change.Methods From January 2015 to January 2018,120 burn patients hospitalized in the department of burn were selected as the research subjects.According to the different nursing methods,they were divided into in the control group (50 cases）and the study group (70 cases).The patients in the control group were treated with routine nursing,and the study group was given comfort nursing intervention on the basis of the control group.The pain scores and stress state of the two groups were compared before and two weeks after the nursing.ResultsAfter nursing,the pain degree and anxiety score of the two groups were lower than those before nursing.The pain degree and anxiety score of the patients in the study group were lower than those in the control group,the differences were statistically significant(P<0.005）.The salivary cortisol levels of the two groups improved compared with those before nursing,but the study group was lower than that of the control group,and the difference was statistically significant(P<0.05）.ConclusionFor the burn patients,taking comfort nursing care can obviously relieve the pain of the wound dressing,and reduce the stress response and speed up the recovery.It is worthy of clinical application. 2018 Vol. 25 (29): 212-214 [Abstract] ( 114 ) HTML (33 KB)  PDF  (0 KB)  ( 24 ) 215 Application effect of peritoneal dialysis fluid transfer process picture method in peritoneal dialysis patients′operation training LI Yin-song;WU Shao-li Objective To explore the effect of the picture method of peritoneal dialysis fluid transfer operation in peritoneal dialysis patients′operation training.Methods A total of 90 cases of peritoneal dialysis catheterization in our hospital from March 2015 to February 2016 were selected and divided into control group and observation group according to random number table method,45 cases in each group.Finally,43 cases in the control group were studied,and the control group was trained by the method of operation demonstration+oral preaching to train the patients with peritoneal dialysis.In the observation group,43 cases were completed.The observation group was trained by operation demonstration+oral teaching+operation flow picture method,and the patients were trained by peritoneal dialysis.ResultsHospitalization time in observation group was(10.5±2.0)d,shorter than that of control group (12.0±1.5)d,(P<0.05）,and the observation group of peritoneal dialysis fluid change qualified rate respectively in 6 months after the intervention and intervention evaluation 12 months were higher than the control group(P<0.05）.In addition,the observation group by peritoneal dialysate exchange lead to peritoneal dialysis related peritonitis in 6 months after the intervention and intervention evaluation 12 months were lower than the control,the differences were statistically significant(P<0.05）.Conclusion The application of peritoneal dialysis fluid change operation training picture law in peritoneal dialysis patients operation can not only shorten the hospitalization time of patients,and help patients to form a correct concept of operations,so as to improve peritoneal dialysis fluid change qualified rate,reduce the incidence of peritoneal dialysis related peritonitis,is a kind of feasible training method. 2018 Vol. 25 (29): 215-217 [Abstract] ( 129 ) HTML (35 KB)  PDF  (0 KB)  ( 22 ) 218 Application effect of coherent nursing health education in chronic cervicitis nursing LONG Hong-ying Objective To explore the feasibility of choosing a coherent nursing health education model during nursing in patients with chronic cervicitis.Methods A total of 150 patients with chronic cervicitis who were admitted to our hospital from December 2015 to January 2018 were selected as the research subjects.By drawing lots,they were equally divided into control group(traditional nursing model)and observation group(traditional nursing model+coherent nursing health education model),75 cases in each group.The treatment time,total nursing effectiveness rate,and total nursing service satisfaction in the two groups were compared.Results The duration of disease treatment was significantly shorter in the observation group than that in the control group (P<0.05）.The total nursing effectiveness rate in the observation group was 98.67%,much higher than that in the[84.00%]with statistical significance(P<0.05）.The total satisfaction on the nursing service in the observation group was 98.67%,significantly higher than that of the control group (82.67%)with statistical significance (P<0.05）.Conclusion Nursing staff choosing the coherent nursing health education model for patients with chronic cervicitis can ensure the shortened treatment time,enhanced nursing effect,and increased nursing satisfaction,so that,promote the recovery of patients with chronic cervicitis. 2018 Vol. 25 (29): 218-220 [Abstract] ( 118 ) HTML (33 KB)  PDF  (0 KB)  ( 21 )

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