稽留流产患者绒毛及蜕膜组织中TLR4、NF-κB的表达及意义

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Abstract Objective To investigate the expression and clinical significance of Toll-like receptor 4(TLR4)and nuclear factor-kappaB (NF-κB)in the villi and decidua of patients with missed abortion.Methods A total of 90 patients with missed abortion treated in our hospital from January 2013 to October 2017 were selected(50 patients with missed abortion and infection were group A,40 patients with missed abortion and no infection were group B)and 50 normal early pregnancy required termination of pregnancy (group C).Immunehisto-chemical SP method was used to detect the expression of TLR4 and NF-κB in chorionic villi and decidua.Results TLR4 and NF-κB were expressed in the three groups of villi and decidua,but the expression of TLR4 and NF-κB in the villi and decidua of group A and B was higher than that of the group C (P＜0.05).There was a positive correlation between the expression of TLR4 and NF-κB in the same villi and decidua in group A (r=0.527,P＜0.05).Conclusion The expression of TLR4 and NF-κB in the villus and decidua of patients with missed abortion is increased,which may be involved in the occurrence and development of missed abortion.

Key words： Missed abortion Toll-like receptor 4 Nuclear transcription factor-kappa B

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	YANG Xiu-lian

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YANG Xiu-lian. Expression and significance of TLR4 and NF-κB in villi and decidua of patients with missed abortion[J]. 中国当代医药, 2018, 25(29): 91-93转96.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I29/91

[1]	Fang Y，Yu S，Ma Y，et al.Association of Dll4/notch and HIF1a-VEGF signaling in the angiogenesis of missed abortion[J].PLoS One，2013，8 （8）： e70667.
[2]	Hwang JH，Kim JW，Hwang JY，et al.Coxsackievirus B infection is highly related with missed abortion in Korea[J].Yonsei Med J，2014，55（6）：1562．
[3]	唐丽娟，谭布珍.生殖道常见病原体感染与稽留流产[J].中华临床感染病杂志，2013，6（4）：254.
[4]	Zhu LJ，Chen YP，Chen BJ，et al.Changes in reactive ox-ygen species，superoxide dismutase and hypoxia-inducible factor-1αlevels in missed abortion[J].Int J Clin Exp Med，2014，7（8）：2179-2184．
[5]	张月莲，王晶晶，廖平川，等.TLR4、CD80与复发性流产的相关性研究[J].中国医师杂志，2015，17（1）：68-70.
[8]	李莎，赵先兰.TLR4，NF-κB 与早期自然流产[J].国际妇产科学杂志 2012，39（2）：175-178.
[9]	曹玉华，叶家枝，张红萍，等.α黑色素细胞刺激素、白细胞介素-6及NF-κB在早产及晚期流产中的表达和临床意义[J].中国妇幼保健，2016，31（16）：3338-3340.
[10]	蔡彦卿，徐亮，张丹丹.α-MSH、IL-6 和 NF-κB 在晚期流产和早产中的表达及意义[J].现代妇产科进展，2015，24（6）：448-450.
[11]	刘常秀，梁金好，周筱燕.孕激素受体与 TNF-α、IL-1β、NF-κB在自然流产蜕膜组织中的表达及临床意义[J].吉林医学，2013，34（33）：6886-6889.
[6]	Friebe A，Douglas AJ，Solano E，et al.Neutralization of LPS or blockage of TLR4 signaling prevents stress-triggered fetal loss in murine pregnancy[J].J Mol Med（Bed），2011，89（7）：689-699．
[7]	Tian J，Zhang FJ，Lei GH.Role of integrins and their ligands in osteoarthritic cartilage[J].Rheumatol Int，2015，35（5）：787-798.
[12]	Fan Y，Liu B.Expression of Toll-like receptors in the mucosa of patients with ulcerative colitis[J].Exp Ther Med，2015，9（4）：1455-1459.
[13]	Lin M，Yiu WH，Wu HJ，et al.Toll-like receptor 4 Promotes tubular inflammation in diabetic nephropathy[J].J Am Soc Nephrol，2012，23（1）：86-102．
[14]	乔俊英，宋丽，张艳丽，等.哮喘小鼠HMGB1/TLR4/NF-κB信号通路及维生素D的作用[J].中国当代儿科杂志，2017，19 （1）： 95-103.
[15]	何姗姗，余娅，高进，等.右侧颈交感干离断对大鼠心肌梗死后炎症反应的抑制作用及对HMGB1/TLR4/NF-κB通路的影响[J].中国病理生理杂志，2018，34（3）：403-409
[16]	朱洪竹，朱梅菊，曾志刚，等.有氧运动加螺旋藻补充对2型糖尿病大鼠肾脏TLR4//NF-κB-p65的表达及炎性因子的影响[J].天然产物研究与开发，2017，29：1119-1126.
[17]	王玉红，张明磊，毛琪，等.肺炎支原体感染对BALB/c小鼠TLR4/NF-κB信号通路表达的影响[J].解剖科学进展，2017，23（3）：242-244.
[18]	Qu Z，Xiao G.Systematic detection of noncanonical NF-κB activation[J].Methods Mol Biol，2015，1280：121-154.
[19]	马涛.溃疡性结肠炎患者肠道菌群紊乱与TLR／NF-κB、炎症介质表达的关系[J].海南医学院学报2017，23（14）：1903-1906.
[20]	白雪，邵小光，李键.复发性流产患者 TLR4、NF-κB p65的表达及意义[J].中国妇幼保健，2015，30（16）：2626-2628.