| [1] |
Subbarao K，Murphy BR，Fauci AS.Development of effective vaccines against pandemic influenza[J].Immunity，2006，24（1）：5-9.
|
| [2] |
Gerdil C.The annual production cycle for influenza vaccine[J].Vaccine，2003，21（16）：1776-1779.
|
| [3] |
Palese P.Making better influenza virus vaccines[J].Emerg Infect Dis，2006，12（1）：61-65.
|
| [4] |
Valkenburg SA，Mallajosyula VV，Li OT，et al.Stalking influenza by vaccination with pre-fusion headless HA ministem[J].Sci Rep，2016，6：22666.
|
| [5] |
Gao D，Chen Y，Han D，et al.Membrane-anchored stalk domain of influenza HA enhanced immune responses in mice[J].Microb Pathog，2017，113：421-426.
|
| [6] |
Horvath A，Toth GK，Gogolak P，et al.A hemagglutininbased multipeptide construct elicits enhanced protective immune response in mice against influenza A virus infection[J].Immunol Lett，1998，60（2/3）：127-136.
|
| [7] |
Li C，Jaentschke B，Song Y，et al.A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide[J].Nat Protoc，2010，5（1）：14-19.
|
| [8] |
Chun S，Li C，Van Domselaar G，et al.Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins[J].Vaccine，2008，26（48）：6068-6076.
|
| [9] |
Bianchi E，Liang X，Ingallinella P，et al.Universal influenza B vaccine based on the maturational cleavage site of the hemagglutinin precursor[J].J Virol，2005，79（12）：7380-7388.
|
| [10] |
Ekiert DC，Bhabha G，Elsliger MA，et al.Antibody recognition of a highly conserved influenza virus epitope[J].Science，2009，324（5924）：246-251.
|
| [11] |
Prabhu N，Prabakaran M，Ho HT，et al.Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection[J].J Virol，2009，83（6）：2553-2562.
|
| [12] |
Sui J，Hwang WC，Perez S，et al.Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses[J].Nat Struct Mol Biol，2009，16（3）：265-273.
|
| [13] |
Fouchier R.A，Schneeberger PM，Rozendaal FW，et al.Avian influenza A virus（H7N7）associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome[J].Proc Natl Acad Sci U S A，2004，101（5）：1356-1361.
|
| [14] |
Graves PN，Schulman JL，Young JF，et al.Preparation of influenza virus subviral particles lacking the HA1 subunit of hemagglutinin:unmasking of cross-reactive HA2 determinants[J].Virology，1983，126（1）：106-116.
|
| [15] |
Sagawa H，Ohshima A，Kato I，et al.The immunological activity of a deletion mutant of influenza virus haemagglutinin lacking the globular region[J].J Gen Virol，1996，77 （Pt7）：1483-1487.
|
| [16] |
Kashyap AK，Steel J，Oner AF，et al.Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies[J].Proc Natl Acad Sci U S A，2008，105（16）：5986-5991.
|
| [17] |
Okuno Y，Isegawa Y，Sasao F，et al.A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains[J].J Virol，1993，67（5）：2552-2558.
|
| [18] |
Wrammert J，Koutsonanos D，Li GM，et al.Broadly crossreactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection[J].J Exp Med，2011，8（1）：181-193.
|
| [19] |
Corti D，Voss J，Gamblin SJ，et al.A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins[J].Science，2011，333（6044）：850-856.
|
| [20] |
Ekiert DC，Friesen RH，Bhabha G，et al.A highly conserved neutralizing epitope on group 2 influenza A viruses[J].Science，2011，333（6044）：843-850.
|
| [21] |
Steel J，Lowen AC，Wang TT，et al.Influenza virus vaccine based on the conserved hemagglutinin stalkdomain[J].M Bio，2010，1（1）：1-9.
|
| [22] |
Wang TT，Tan GS，Hai R，et al.Vaccination with a synthetic peptide from theinfluenza virus hemagglutinin provides protection against distinct viral subtypes[J].Proc Natl Acad Sci U S A，2010，107（44）：18979-18984.
|
| [23] |
Krammer F，Pica N，Hai R，et al.Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies[J].J Virol，2013，87 （12）：6542-6550.
|
| [24] |
Ramirez A，Morris S，Maucourant S，et al.A virus-like particle vaccine candidate for influenza A virus based on multiple conserved antigens presented on hepatitis B tandem core particles[J].Vaccine，2018，36（6）：873-880.
|
| [25] |
Tamar BY，Marcus H，Reisner Y，et al.Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection[J].Int Immunol，1999，11（7）：1043-1051.
|
| [26] |
Adar Y，Singer Y，Levi R，et al.A universal epitope-based influenza vaccine and its efficacy against H5N1[J].Vaccine，2009，27（15）：2099-2107.
|
| [27] |
Atsmon J，Caraco Y，Sagit ZS，et al.Priming by a novel universal influenza vaccine（Multimeric-001)-a gateway for improving immune response in the elderly population[J].Vaccine，2014，32（44）：5816-5823.
|
