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2018 Vol. 25, No. 17
Published: 2018-06-18
 
 
4 Prokaryotic expression of latency-associated peptide of recombinant truncated TGF-β precursor and its influence on proliferation of HSC-T6 cell
SHIYong-ping；ZHENGJun-ya；LIUZeng-rui；LILu-xin；WANGJing；LILing-yu；CAOYa-nan；CHUYan-hui
ObjectiveTo preliminarily study the influence of recombinant protein of latency-associated peptide(LAP)of recombinant truncated TGF-β precursor on proliferation of hepatic stellate cells　(HSC)-T6.MethodsThe truncated LAP fragment was amplified by polymerase chain reaction(PCR)and the prokaryotic expression vector was constructed.After double enzyme digestion and DNA sequencing,the protein expression was induced by IPTG at 0.5 mmol/L at 37°C for 4 h.The expressed protein was detected by SDS-PAGE and Western blot,after that the recombinant protein was by nickel agarose affinity chromatography for purification.The recombinant protein was applied to rat hepatic stellate cell-T6　(HSC-T6),and the influence of different concentrations of recombinant protein on cell proliferation was detected by MTT assay.ResultsThe prokaryotic expression vector was successfully constructed and the recombinant protein was expressed and purified successfully.The proliferation of HSC-T6 cells decreased with the increase of the recombinant protein concentration.ConclusionThe recombinant protein inhibits the proliferation of HSC-T6 cells,and lays the foundation for the subsequent study on the interference of LAP fragments on the activation of TGF-β and the influence on organ fibrosis.
2018 Vol. 25 (17): 4-7 [Abstract] ( 146 ) HTML (41 KB)  PDF  (0 KB)  ( 37 )
8 The value of ultrasound score combined w ith medical history for predicting the risk degree of pernicious p lacenta previa
YANG De-lan　；ZHU Bao-ju
ObjectiveTo explore the value of ultrasound score combined with medical history for predicting the risk degree of pernicious placenta previa.MethodsClinical data of 58 patients with pernicious placenta previa treated in obstetrics department of our hospital and given terminal pregnancy from May to December 2017 were retrospectively analyzed.Prenatal diagnosis of pernicious placenta previa and placenta accrete was performed according to the ultrasound score scale combined with medical history score.The coincidence rate of the diagnosis,the sensitivity,and the specificity were evaluated after operation.At the same time,the receiver operating characteristic curve(ROC curve)was plotted and the area under the curve　(AUC)was calculated.The cut-off score for each type of placenta accrete was calculated.ResultsAll patients were considered as pernicious placenta previa before surgery.Postoperatively,according to the ultrasound scoring combined with medical history,the coincidence rate of the diagnosis of pernicious placenta previa and placenta accreta,the sensitivity,and the specificity was 93.1%(54/58),94.5%(52/55),and 66.7%(2/3)respectively.According to the ROC curve,AUC of the adhesion type and the implant type was 92.5%.The corresponding value of the maximum index was 7.5 points,and the sensitivity and specificity was 76.9%and 84.6%respectively.Therefore,the boundary value of the adhesions and implants was 8 points.AUC of the implants and penetrating was 92.7%,and the corresponding value of the largest one was 11.5 points,and the sensitivity and specificity was 89.5%and 81.8%respectively.Therefore,the boundary value of the implants and penetrating types was 12 points.ConclusionFor pregnant women who are suspected to the pernicious placenta previa during the third trimester,ultrasound score combined with medical history can be used to predict the degree of risk before delivery.So,it can make the corresponding treatment plans in advance,to improve the quality of maternal and child perinatal life as much as possible.
2018 Vol. 25 (17): 8-11转15 [Abstract] ( 160 ) HTML (42 KB)  PDF  (0 KB)  ( 25 )
12 The relationship between GSK-3 beta and Drp-1 in alleviating myocardial ischem ia reperfusion injury in rats
LUO Wei-hao；HE Jian-dong；HAN Chong-fang2▲
ObjectiveTo investigate the relationship between GSK-3β and Drp-1 in the myocardium protection in rats.Methods60 healthy male SD rats,weighing 250-300 g,randomly divided into 4 groups　(n=15)：Ischemia reperfusion group(group IR),Ischemia reperfusion+Mivi-1 treatment group(group M),Ischemia reperfusion+SB216763 treatment group(group B),and Ischemia reperfusion+Mivi-1 treatment group+SB216763 treatment group(group D).The myocardial ischemia-reperfusion injury model was established by ligating the LAD for 30 min and reperfusion for 120 min.Mdivi-1(1.2 mg/kg)was given at 1 min before reperfusion in group M by intravenous injection.SB216763(0.2 mg/kg)was given at 1 min before reperfusion in group B by intravenous injection.Both of them were given at 1 min before reperfusion in group D by intravenous injection.cTnI concentration was detected from abdominal aorta blood.Myocardial specimens were obtained from the apex for determination of the AI by TUNEL.Myocardial pathology were observed and the expression of caspase-3 was detected by Western blot.ResultsCompared with IR group,the levels of caspase-3,AI and myocardial injury in M,B and D groups were down-regulated(P<0.05).Compared with D group,the levels of caspase-3,AI and myocardial injury were increased in M and B group the differences were statistical significant(P<0.05).Conclusion The relationship between GSK-3β and Drp-1 of the myocardium protection in rats is not a single dependency.
2018 Vol. 25 (17): 12-15 [Abstract] ( 145 ) HTML (39 KB)  PDF  (0 KB)  ( 25 )
16 Effect of Huangqi Yiqi Decoction combined w ith western medicine in patients w ith chronic atrophic gastritis
LIANG Wan-ning；HOU Yan-ping；QIAN Cai-feng；MEI Quan-xi
ObjectiveTo investigate the effect of Huangqi Yiqi Decoction combined with western medicine in the treatment patients with chronic atrophic gastritis.MethodsEighty-five patients with chronic atrophic gastritis admitted to People′s Hospital of Gaoyao District in Zhaoqing City from March 2014 to January 2017 were selected as study subjects and randomly divided into：observation group(42 cases)and control group(43 cases).Patients in the control group were treated with Omeprazole,Colloidal Pectin Bismuth and Amoxicillin on the basis of general treatment.The patients in the observation group were given Huangqi Yiqi Decoction,Omeprazole and Colloidal Pectin Bismuth on the basis of general treatment.The total effective rate of clinical curative effect,the total effective rate of gastroscope curative effect,the clearance rate of Helicobacter Pylori infection,the biopsy pathology and the quantification of chronic atrophic gastritis symptoms were observed.ResultsAfter treatment,the total effective rate of clinical curative effect,the total effective rate of gastroscopy,the total effective rate of biopsy pathological treatment was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in HP infection clearance between the two groups(P＞0.05).After treatment and follow-up six months,the observation group of patients with chronic atrophic gastritis symptom score were lower than the control group,the difference was statistically significant(P<0.01).ConclusionHuangqi Yiqi Decoction combined with western medicine can effectively improve the clinical symptoms of patients with chronic atrophic gastritis,have a certain role in eradicating HP infection,and the long-term effect is good,worthy of clinical promotion.
2018 Vol. 25 (17): 16-19 [Abstract] ( 167 ) HTML (43 KB)  PDF  (0 KB)  ( 30 )
20 Effects of Haw thorn,Eucomm ia and Tangerine Peel m ixture decoction on reducing fat in obese rats induced by high fat diet
LIN Yuan-yuan；　XIONG Yi-tao
ObjectiveTo investigate the effect of Tangerine Peel,Eucommia and Hawthorn mixture decoction on reducing fat in obese rats induced by high fat diet.MethodsA total of 50 Wistar male rats who fed with high fat diet to establish the rat model of obesity were selected as subjects,which were divided into model group,positive group,low-dose group,middle-dose group and high-dose group randomly,10 rats in each groups.In addition,10 normal feeding rats were selected as the control group.The low-dose group,the middle-dose group and the high-dose group were treated with 1 ml/100 g,2 ml/100 g,4 ml/100 g herbal mixture decoction respectively each day.The rats in the positive group were intragastric Orlistat Suspension 60 mg/kg by gavage.All were treated continuously for 8 weeks.The model group and the control group were given normal saline by gavage with the same method.The content of serum triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)in serum and the contend of fatty acid synthase(FAS),acyl coenzyme A oxidase(ACO)in liver were detected by enzyme-linked immunosorbent assay.The number of intestinal flora of rats in each group were compared.ResultsThe weight,Lee′s index,TG,TC,LDL-C and FAS contents of the rats in the model group were significantly higher than those in the control group,and HDL-C and ACO of the rats in the model group were lower than those in the control group,the differences were statistically significant(P<0.05).The weight and Lee′s index,TG,TC,LDL-C and FAS contents of the rats in the high-dose group were significantly lower than those in the model group,and the levels of HDL-C and ACO of the rats in the high-dose group were significantly higher than those in the model group,the differences were statistical-ly significant(P<0.05).The number of bifidobacterium,lactobacillus and enterococcus in the intestinal tract of rats in high-dose group were higher than those in the model group,and the number of escherichia coli was less than that of the model group,the differences were statistically significant(P<0.05).There were no statistically significant differences in Lee′s index,TG,TC,LDL-C,FAS and ACO of rats in high-dose group compared with the positive group　(P>0.05).ConclusionThe three herbs mixed decoction of Tangerine Peel,Eucommia and Hawthorn can inhibit the activity of FAS,promote the activity of ACO and increase the number of probiotics.It had a significant effect on reducing weight and blood lipids in obese rats induced by high fat diet.
2018 Vol. 25 (17): 20-23转28 [Abstract] ( 162 ) HTML (45 KB)  PDF  (0 KB)  ( 34 )
24 Research progress of hypotension after prone position in patients w ith hypertension during spinal surgery
WANG Lin；CHEN Li
In the current clinical anaesthesia work,the incidence of hypertensive disease has significantly increased in patients with general anesthesia underwent prostrate spine surgery.The inferior vena cava is reduced because of the abdominal and thoracic compression in the prone position,and the ventricular compliance is decreased which resulted in the decline of the SV that leading to the hypotension.Antihypertensive drugs which taken by the chronic hypertensive patients cause the autonomic nervous function inhibition and blood pressure regulation impaired,and the sympathetic inhibition and vascular dilatation of general anesthesia further aggravate the hypotension.Hypotension can reduce the blood flow and perfusion of important organs,cause related complications,prolong hospital lengths of stay and even increase mortality.Hypertensive patients are more likely to be organ damaged,and are less resistant to the occurrence of hypotension.When hypotension occurs,it can be corrected by using intravenous infusion and vasoactive agents,or decreasing the level of anesthesia.The application of goal-directed fluid therapy and α1adrenergic receptor agonist ensure the stability of hemodynamic during surgery and make the patient recover quickly.In this paper,the causes of hypotension occurred in patients with hypertensive during spine surgery are reviewed,as well as the effects on organism and how to prevent and treatment.
2018 Vol. 25 (17): 24-28 [Abstract] ( 126 ) HTML (47 KB)  PDF  (0 KB)  ( 142 )
29 Pre-pregnancy assessment and intervention measures for the reproductive ability of elderly women
LI Xiao-mei
With the universal two-child policy carrying out,the group preparing to give birth to a second baby is enlarging rapidly,most of which are elderly women.These elderly women are always confronted with the decrease in the number of follicles and the quality of ova,resulting in the damage to fertility.In addition,some gestational deceases such as gestational diabetes and hypertension further increase the risk of pregancy,therefore,it was significant to have a detailed assessment inadvanced for the elderly women.In order to evaluate the reproductive capacity of elderly women and take corresponding intervention measures,the factors that affect the fertility of elder women were discussed.A variety of auxiliary examinations and questionnaires were used to carry out a comprehensive assessment of the reproductive ability of the elderly women before pregnancy,and the corresponding intervention measures were taken to solve the problems in the evaluation and the risk.Finally,the purpose of helping the elderly women to succeed in pregnancy was achieved.
2018 Vol. 25 (17): 29-32 [Abstract] ( 141 ) HTML (41 KB)  PDF  (0 KB)  ( 24 )
33 Clinical app lication of exhaled nitric oxide measurement in asthamachronic obstructive pulmonary disease
DING Yue-mei； SHI Chang-li ；YU Jiang-qing；　WANG Qing-feng
ObjectiveTo study the clinical application effect of exhaled nitric oxide measurement on asthama-chronic obstructive pulmonary disease　(ACOS).MethodsForty-two patients with asthma-chronic,simple asthma,simple chronic obstructive pulmonary disease and non-respiratory diseases who were admitted and diagnosed in our hospital from July 2013 to March 2017 were selected and observation group,control group A,control group B and control group C respectively.before medication,four groups of patients accepted the measurement of exhaled nitric oxide,and the differences between the measurement of exhaled nitric oxide in observation group and the control group were compared.ResultsThe feNO value of the patients in the observation group was lower than that of the control group A,and the difference was statistically significant(P<0.05).FeNO values of patients in the observation group were significantly higher than those in the control groups B and C,and the differences were statistically significant(P<0.05).The probability of FeNO≥27 ppb in the observation group was higher than that in the control group A,and there was no significant difference(P<0.05).The probability of FeNO≥27 ppb in the observation group was significantly higher than that in the control group B and C,and the differences were statistically significant(P<0.05).ConclusionThe measured value of exhaled nitric oxide in patients with asthma-chronic obstructive pulmonary disease is significantly different from those of asthma alone,COPD alone,and other non-respiratory diseases.Therefore,exhaled nitric oxide measurement plays a great differential diagnosis role in asthma-chronic obstructive pulmonary disease and has an application value.
2018 Vol. 25 (17): 33-35 [Abstract] ( 174 ) HTML (33 KB)  PDF  (0 KB)  ( 23 )
36 Clinical effect of laparoscopic peritoneal lavage and drainage in the treatment of severe pancreatitis
BAO Xing；　XIN Le；　LIU Ji-dong；　YE Jin-jun；　TAO Xu-xiong；　YAN Yu-kuang
ObjectiveTo summarize the clinical efficacy of laparoscopic peritoneal lavage and drainage　(LPLD)in the treatment of severe acute pancreatitis(SAP).MethodsFifty-two patients with severe SAP admitted to our hospital from January 2015 to September 2017 were selected as research objects,and were divided into control group and experimental group according to random number table method,with 26 cases in each group.The control group was treated with traditional laparotomy,and the experimental group was treated with LPLD,and the clinical therapeutic effects of the two groups were compared.ResultsThe operation time of the experimental group was significantly longer than that of the control group　(P<0.05),and the extubation time and hospitalization time of the experimental group were significantly shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the differences were statistically significant(P<0.05).The recovery time of each indexes level and the remission time of clinical symptoms in the experimental group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).The incidence of complications in the experimental group was significantly lower than that in the control group(P<0.05).ConclusionLPLD can achieve satisfactory results in the treatment of severe SAP,which can help reduce the amount of intraoperative blood loss,shorten the postoperative length of stay and the recovery time of symptoms,reduce the incidence rate of complications,and have a higher safety.It is suggested to put this method into promotion and application in a widespread manner.
2018 Vol. 25 (17): 36-38 [Abstract] ( 152 ) HTML (33 KB)  PDF  (0 KB)  ( 33 )
39 Effect of smoking cessation and passive smoking prevention in patients w ith chronic obstructive pulmonary disease
YUAN Ya；　ZHU Jia-zhi ；LI Shu-Zhen；　ZENG Guang；　PENG Ming-Jun
ObjectiveTo explore the effect of smoking cessation and prevention of passive smoking in patients with chronic obstructive pulmonary disease.MethodsA total of 300 patients with chronic obstructive pulmonary disease admitted to our hospital from March 2016 to December 2017 were selected as research objects.According to the time sequence of patients admitted,patients with odd numbers were divided into control group and patients with even numbers were divided into experimental group,with 150 cases in each group.The control group was given traditional treatment,and the experimental group was given smoking cessation and passive smoking prevention intervention on the basis of the control group.The clinical symptom score,pulmonary function index,treatment effect and 3 months follow-up after discharge were compared between the two groups.ConclusionBefore treatment,there was no statistically significant difference in the scores of clinical symptoms between the two groups(P>0.05).After treatment,the scores of clinical symptoms in experimental group were significantly less than those in control group,and the difference was statistically significant(P<0.05).There was no significant difference between the two groups in lung function indexes before treatment(P<0.05).After treatment,the pulmonary function index of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of patients in the experimental group was significantly higher than that in the control group(P<0.05).Three months after discharge,there were 24 cases of disease recurrence in the experimental group and 41 cases of disease recurrence in the control group.The disease recurrence rate in the observation group was 21.05%(24/114),it was lower than 67.21%(41/61)in the control group,and the difference was statistically significant(χ2=36.27,P=0.00).Conclusionsmoking cessation and prevention of passive smoking intervention have positive effects on improving lung function and reducing morbidity in patients with chronic obstructive pulmonary disease,which can be further promoted and implemented in clinical practice in the future.
2018 Vol. 25 (17): 39-41转45 [Abstract] ( 150 ) HTML (36 KB)  PDF  (0 KB)  ( 25 )
42 Relationship study between preschool children′s dental caries and maternal pregnancy and child related factors
DENG Xiao-juan；HUANG Wen-min；CUI You-zu
ObjectiveTo analyze the association of preschool children′s dental caries with maternal and child-related factors.MethodsFrom January to December,2017,218 children aged 3 to 6 with caries in 68 kindergartens in 17 towns of Boluo County were selected as the observation group by cluster sampling,and 200 normal preschool children who underwent health examination in our hospital at the same time were selected as the control group.The clinical data children and mothers in two groups of were collected and analyzed.ResultsThe clinical data of pregnant women in the observation group were compared with each other,and the difference was statistically significant(P<0.05).There was statistically significant difference between the two groups in children′s clinical data(P<0.05).Logistic regression analysis showed that pregnant women′s caries,inadequate nutrition during pregnancy,pregnant women′s poor pregnancy history,pregnant women′s first or second hand smoke,pregnant women′s oral symptoms,pregnant women′s complications,pregnant women′s educational level at or below the tertiary level,pregnant women′s toothache were high-risk factors for pregnant women whether preschool children suffered from caries or not(P<0.05).Premature infants,preference for sweets,no brushing habits twice in the morning and evening,and children′s brushing starting age ≥ 2 years old were all high-risk factors for children with dental caries in preschool children,and the differences were statistically significant(P<0.05).ConclusionPreschool children have relationship with preterm infants,brushing rate 2 times in the morning and evening,sweet tooth food,maternal education,maternal toothache during pregnancy,complications during pregnancy,first-hand or secondhand smoke,adequate nutrition during pregnancy,and incidence of mother′s caries.
2018 Vol. 25 (17): 42-45 [Abstract] ( 159 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
46 Effect of Shenkang Injection on peripheral blood IFN-γ,IL-4,IL-17 and homocysteine levels in patients w ith chronic glomerulonephritis
LI Ping-hua ；PAN Fu-lin；　LIU Wei-li； CHEN Wei-wei ；SHAO Lei ；HUANG Geng；　CHEN Zai-qiang； ZHANG Si-han
ObjectiveTo investiage the effect of Shenkang Injection on chronic glomerulonephritis and the influence of peripheral blood INF-γ,IL-4,IL-17and homocysteine levels.MethodsNinety-eight patients with chronic glomerulonephritis admitted to our hospital from April 2015 to August 2017 were selected as research objects,and were divided into control group and observation group by random number table method,with 49 cases in each group.Among them,patients in control group were treated with Benazepril,and patients in observation group were treated with Shenkang Injection on the basis of this,and related clinical indexes data of the two groups were observed and compared,including total effective rate of treatment,blood pressure before and after treatment,renal function before and after treatment,IFN-γ,IL-4,IL-17 and homocysteine levels in peripheral blood before and after treatment,etc.ResultsThe total effective rate of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).There were 1 case of rash,1 case of pruritus in the observation group,2 cases of rash and 1 case of pruritus in the control group.there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).There was no significant difference in blood pressure between the two groups before treatment(P>0.05).After treatment,the blood pressure of both groups was lower than before treatment,the blood pressure in the observation group was lower than that in the control group after treatment,and the differences were statistically significant(P<0.05).There was no significant difference in renal function indexes between the two groups before treatment(P<0.05).After treatment,the renal function indicators of the two groups were lower than those before treatment,and those of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in INF-γ,IL-4And IL-17 levels in peripheral blood between the two groups　(P<0.05).After treatment,INF-γ and Il-4 in peripheral blood of both groups were lower than those before treatment,and IL-17 was higher than that before treatment.After treatment(P<0.05),the serum,INF-γ and IL-17 levels of patients in the observation group were lower than those in the control group,and the serum IL-4 levels of patients in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in homocysteine levels between the two groups before treatment(P>0.05).After treatment,the homocysteine levels in both groups were lower than those before treatment,the homocysteine level in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).ConclusionShenkang Injection of chronic glomerulonephritis with the effect is superior to Benazepril alone in the application.The effects on peripheral blood levels of IFN-γ,IL-4,IL-17 and homocysteine is significant.Therefore it can be popularized and applied in clinic.
2018 Vol. 25 (17): 46-49 [Abstract] ( 150 ) HTML (40 KB)  PDF  (0 KB)  ( 23 )
50 Application effect of nutritional intervention in gestational diabetes mellitus patients
LIU Xiao-yang
ObjectiveTo explore the effect of nutritional intervention in patients with gestational diabetes mellitus.MethodsA total of 82 cases of gestational diabetes mellitus admitted in our hospital from January to June,2017 were retrospectively analyzed,and divided into control group and observation group according to whether they were willing to accept nutritional intervention,with 41 cases in each group.The control group received routine intervention,and the observation group combined with nutritional intervention on the basis of routine intervention,and the weight changes and pregnancy outcomes of the two groups of patients were counted and compared.ResultsThe weight gain during pregnancy in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).In the Apgar scores of newborns in the observation group,the proportion of scores of 0-3 points and 4-7 points were lower than those in the control group,the proportion of scores of 8-10 points was higher than those in the control group,and the incidence of macrosomia in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).ConclusionNutritional intervention for patients with gestational diabetes can effectively reduce weight gain during pregnancy,reduce complications and macrosomia,and improve neonatal Apgar score,which is worthy of popularization and application.
2018 Vol. 25 (17): 50-52 [Abstract] ( 141 ) HTML (31 KB)  PDF  (0 KB)  ( 39 )
53 Effect analysis of emergency rescue combined w ith low-dose Epinephrine in treatment of patients w ith severe asthma
GAO Peng；QIAO Xiao-xue；XUE Xin-yu；WU Xian；　LI Yang
ObjectiveTo observe and analyze the clinical efficacy of emergency rescue combined with low-dose Epinephrine in treatment of patients with severe asthma.MethodsEighty-six patients with severe asthma admitted to our hospital from November 2015 to November 2017 were selected and randomly divided into control group and observation group according to the random number table method,with 43 cases in each group.The control group was treated with routine emergency rescue and conventional drugs such as Methylprednisolone and Aminophylline.The observation group was based on the treatment measures of the control group and added with low-dose of Epinephrine,and the changes of heart rate,respiratory rate,blood oxygen saturation and other indicators and therapeutic effects of the two groups were observed and compared.ResultsAfter treatment,the respiratory frequency and heart rate of patients in the observation group were lower than those in the control group,and the blood oxygen saturation was higher than that in the control group,the differences were statistically significant(P<0.05).The total effective rate of patients in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(P>0.05).ConclusionCombination of application of emergency rescue and low-dose Epinephrine is effective and safe in treatment of severe asthma patients,which is worthy of clinical application.
2018 Vol. 25 (17): 53-55 [Abstract] ( 171 ) HTML (34 KB)  PDF  (0 KB)  ( 36 )
56 Com parison of the effects of ventriculoperitoneal shunt and cranioplasty in the treatment of cerebral trauma w ith hydrocephalus
WU Sheng-qing；　ZENG Zhen-kun；　LI Jing-dong；　WU Hai-qing；　HUANG Wei
ObjectiveTo observe the different effects of homochronous and staging operative treatment of ventricularperitoneal shunt and skull repair for traumatic brain injury with hydrocephalus.MethodsSixty-two patients with traumatic brain injury and hydronephrosis admitted to our hospital from January 2013 to June 2017 were selected as the research objects,and divided into the same period group（35cases） and the staging group　（27cases） according to the time interval between ventriculoperitoneal shunt and skull repair,and the same period group was conducted with two kinds of operations at the same time.The staging group was treated with ventriculoperitoneal shunt first，and then cranioplasty was performed after interval of 1-3 months.The daily life ability(Barther index),limb movement function(Fugl-Meyer index),Glasgow coma index(GCS),clinical efficacy and complication rate of the two groups were compared before and after treatment.ResultsThere was no significant difference in Bart her index，fugl-Meyer index and GCS index between the two groups before treatment(P>0.05).Barther index，Fugl-Meyer index and GCS index of the two groups increased significantly after treatment，and the rising amplitude of the same period group was significantly larger than that of the staging group，and GOS index of the same period group was higher than that of the staging group，with statistically significant difference　(P<0.05).The excellent and good rate of treatment in the same period group was significantly higher than that in the stage group，and the difference was statistically significant(P<0.05).There were 5 patients with complications in the same period and 10 patients with complications in the staging group,and the complication rate of 14.29%in the same period was significantly lower than that of 37.04%in the staging group,the difference was statistically significant(χ2=4.302;P=0.038).ConclusionHomochronous ventricular-peritoneal shunt and skull repair has a better curative effect and prognosis than staging surgery，it has the advantages of fast recovery，less postoperative complications.
2018 Vol. 25 (17): 56-58 [Abstract] ( 142 ) HTML (34 KB)  PDF  (0 KB)  ( 37 )
59 Clinical efficacy of Alprostadil sequential therapy in the treatment of elderly patients w ith clinical diabetic nephropathy
ZENG Zhi-yong ；YAN Hai-lan；　HU Yan-hong ；WANG Yan-hong
ObjectiveTo investigate the clinical efficacy of Alprostadil as a sequential therapy in the treatment of clinical diabetic nephropathy in the elderly.MethodsA total of 200 elderly patients with diabetic nephropathy in clinical stage who were admitted in our hospital from February 2015 to September 2017 were selected as research objects,and randomly divided into routine group and research group,with 100 cases in each group.Routine group was treated with Alprostadil therapy on the basis of routine treatment,while research group was treated with Alprostadil sequential therapy on the basis of routine treatment,and the therapeutic efficacy and renal function indexes changes before and after treatment were compared between the two groups.ResultsThe total effective rate of treatment in the study group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the renal function indexes of the two groups of patients were lower than those before treatment,and the renal function indexes of the patients in the study group were higher than those of the conventional group,the difference was statistically significant(P<0.05).ConclusionOn the basis of routine treatment,application of Alprostadil as a sequential therapy in the treatment of elderly patients with clinical diabetic nephropathy obtains a better clinical effect,which can improve the therapeutic efficacy and significantly ameliorate the patients′various renal function indexes.
2018 Vol. 25 (17): 59-61 [Abstract] ( 139 ) HTML (31 KB)  PDF  (0 KB)  ( 24 )
62 Evaluation of the effect of preoperative pillow and percutaneous vertebrop lasty in the treatment of osteoporotic thoracolumbar com pression fractures
CHEN Wen-sheng；　SHEN Lian-cheng；　LONG Hou-cai ；FANG Xiao-ting
ObjectiveTo investigate the clinical effect of preoperative pillow and percutaneous vertebroplasty　(PVP)in the treatment of osteoporotic thoracolumbar vertebral compression fractures.MethodsSixty patients with osteoporotic thoracolumbar vertebral compression fractures admitted to our hospital from February 2014 to June 2017 were selected and divided into control group and study group with 30 cases in each group by random number table method.The control group was treated with PVP,while the study group was treated with preoperative pillow and PVP.The clinical efficacy of the two groups were compared,as well as the vas scores,vertebral anterior height compression ratio,vertebral central height compression ratio and Cobb angle changes before and after 3 d,3 and 6 months.ResultsThe total clinical effective rate in the study group was significantly higher than that in the control group(P<0.05).There was no statistically significant difference in vas scores between the two groups before surgery and 3 days　(P>0.05).The VAS scores of the two groups at 3 and 6 months after surgery were significantly lower than those before surgery,and the VAS scores of the study group at 3 and 6 months after surgery were lower than those of the control group,and the difference was statistically significant(P<0.05).Before surgery,there was no significant difference between the two groups　(P>0.05)in the compression ratio of the height of the anterior vertebral edge.The compression ratio of the height of the anterior verte-bral edge of the two groups at 3 d,3 and 6 months after surgery was significantly lower than that before surgery,and the compression ratio of the height of the anterior vertebral edge of the patients in the study group was significantly lower than that of the control group,the difference was statistically significant(P<0.05).Before surgery,there was no statistical difference between the two groups(P>0.05).at 3 d,3 and 6 months after surgery,the compression ratio of the height of the middle vertebra in the study group was significantly lower than that before surgery,and the compression ratio of the height of the middle vertebra in the study group was significantly lower than that in the control group，the difference was statistically significant(P<0.05).The compression ratio of the height of the middle vertebra in the control group at 3 d after surgery was significantly lower than that before surgery,and the difference was statistically significant(P<0.05).Before surgery,there was no significant difference in Cobb angle between the two groups at different stages,the difference was statistically significant(P>0.05).The Cobb angle of the two groups at 3 d,3 and 6 months after surgery was significantly lower than that before surgery,and the Cobb angle of the study group was significantly lower than that of the control group,the difference was statistically significant(P<0.05).ConclusionThe treatment of osteoporotic thoracic and lumbar vertebral compression fractures with anterior cushion and PVP can significantly relieve pain,restore height of vertebral body and correct Cobb angle malformation.The curative effect is definite.
2018 Vol. 25 (17): 62-65 [Abstract] ( 123 ) HTML (39 KB)  PDF  (0 KB)  ( 37 )
66 The value of gastric filling ultrasound in the screening of gastric cancer in community
YU Yong-ming；GUO Yan
ObjectiveTo explore the value of gastric filling ultrasonography in the screening of gastric cancer in the community.MethodsFrom May 2013 to May 2015,500 community people who received gastric cancer screening in our hospital were selected as the subjects.All the participants were examined by gastric filling ultrasound.According to the results of gastroscopy and case diagnosis,the results of gastric filling ultrasound were analyzed.Results①405 positive cases were detected by gastric filling ultrasound，and the positive rate was 81%.A total of 415 positive cases were detected by gastroscopy and pathological diagnosis,and the positive rate was 83%.There was no significant difference between the two groups(P＞0.05).The accuracy of gastric filling ultrasound was 71%,and the accuracy of gastroscopy and pathological diagnosis was 70.2%.There was no significant difference between groups(P＞0.05).ConclusionThe gastric ultrasonography examination in screening of gastric cancer，with a high degree of accuracy，especially applied to children and the elderly to gastroscopy intolerance group,its value is more significant,therefore,can be widely used in the diagnosis,treatment,follow-up and referral links.
2018 Vol. 25 (17): 66-68 [Abstract] ( 151 ) HTML (33 KB)  PDF  (0 KB)  ( 28 )
69 Effect observation of laparoscopic im plantation of125I radioactive particles combined Gem citabine chemotherapy after surgery for advanced pancreatic cancer
125I radioactive particles combined Gem citabine chemotherapy after surgery for advanced pancreatic cancer[J]. 中国当代医药, 2018,25(17): 69-71')" href="#"> ZHONG Zhen-wu；ZHONG Hui；LIU Ling；XIE Ling-yan；XU Shu-mei
ObjectiveTo observe the clinical effect of Gemcitabine chemotherapy in the treatment of advanced pancreatic cancer after laparoscopic implantation of125I radioactive particles.MethodsFrom May 2016 to May 2017,40 patients with advanced pancreatic cancer treated in our hospital were enrolled as the research object.With the consent of the patients,they were evenly divided into reference group and research group by drawing lots.In the reference group,Gemcitabine chemotherapy alone was used,while in the research group,laparoscopic implantation of125I radioactive particles followed by Gemcitabine chemotherapy was adopted.The diameters of tumor,jaundice index and body weight were compared between the two groups after treatment.The symptoms of abdominal pain and ascites,and nutritional status of the patients in both groups were observed and the improvement rates were compared.The occurrence of pancreatic fistula and hemorrhage was observed and recorded in the research group and the safety of the operation was summarized.ResultsAfter treatment,the tumor diameter of the research group was significantly smaller than that of the reference group.The jaundice index was significantly lower,and the weight gain increased obviously compared with those in the reference group.In the research group,the improvement rates of abdominal pain,ascites and nutritional status were higher than those in the reference group.The indexes mentioned above were displayed statistical significance between the two groups(P<0.05).The incidence of relevant complications in the research group was 10.00%,which was not significantly different from that in the reference group accounting for 0.00%(P＞0.05).ConclusionAfter laparoscopic implantation of125I radioactive paticles,combination of Gemcitabine chemotherapy in patients with advanced pancreatic cancer can effectively reduce tumor size,decrease jaundice index,relieve the symptoms of abdominal pain and ascites,improve the nutritional status,and help patient to gain weight as well as improve quality of life.In addition,the incidence of relevant complications after particle implantation is low,the combined therapy is safe and effective for the treatment of advanced pancreatic cancer and is worth promoting.
2018 Vol. 25 (17): 69-71 [Abstract] ( 152 ) HTML (35 KB)  PDF  (0 KB)  ( 140 )
72 Causes and preventive measures of com plications of modified radical mastectom y for breast cancer
HUANG Han-yang； HUANG Jing-yin； XIAO Li ；WAN De-yan
ObjectiveTo explore the causes and preventive measures of complications of modified radical mastectomy for breast cancer.MethodsAltogether 60 cases of patients who underwent modified radical mastectomy in our hospital from January 2014 to December 2017 were selected as the observation object.The clinical data of 60 patients were analyzed retrospectively.Combined with the complications,all the patients were divided into complication group　(23 cases)and non-complication group　(37 cases).The causes and preventive measures of complications of modified radical mastectomy for breast cancer were studied.ResultsThe inappropriate surgical incision selection rate,incomplete intra-operative hemostasis rate,unreasonable axillary dissection rate,improper use of electric knife,improper free flap rate,postoperative premature radiotherapy,post-operative over-pressurized bandage rate,and post-operative over-thick incision dressings rate of complication group were significantly higher than those of non-complication group with statistically significant(P<0.05).Logistic regression analysis showed that influencing factors leading to complications of modified radical mastectomy for breast cancer included inappropriate surgical incision selection,incomplete intra-operative hemostasis,unreasonable axillary dissection,improper use of electric knife,improper free flap,post-operative premature radiotherapy,post-operative over-pressurized bandage and post-operative over-thick incision dressings.ConclusionThere are many reasons for the complications of modified radical mastectomy,such as inappropriate surgical incision selection,incomplete intra-operative hemostasis,unreasonable axillary dissection,improper use of electric knife and improper free flap.The clinicians should choose appropriate surgical incision pre-operatively,act strictly in accordance with the standard intra-operatively and provide proper dressing treatment of incisions post-operatively so as to reduce the postoperative complications of the patients.
2018 Vol. 25 (17): 72-74转89 [Abstract] ( 142 ) HTML (32 KB)  PDF  (0 KB)  ( 21 )
75 Application effect of crescent incision combined w ith abdom inal advancement flap in breast conserving surgery for moderate-to small-sized breast cancer
WANG Xi-yue；　CAO Yin；　CHEN Gui-lin　；YE Hui-rong；　GAO Xue-zhong；　LIN Zheng-quan；　WU Li-hua ；CHEN Li-juan
ObjectiveTo evaluate the application effect of crescent incision combined with abdominal advancement flap in breast conserving surgery for moderate-to small-sized breast cancer.MethodsFrom December 2014 to May 2017,thirty-eight moderate-to-small sized breast patients whose tumor was located in the lower pole of our hospital were included.According to the different application of incision in breast conserving surgery,the patients were divided into the two groups:crescent incision breast conserving group(observation group,n=18)and the inverted T shape incision breast conserving group　(control group,n=20).The breast volume,the tumor diameter,the amount of tissue excised,the proportion of tissue excised amount,the postoperative complications and the cosmetic effect in patients between the two groups were compred.Statistically analyzed was conducted with SPSS 19.0 software.ResultsBreast volume in the observation group was smaller than that of the control group,the proportion of tissue excised amount in the observation group was higher than that of the control group,and there was a statistical difference(P＜0.05).The median follow-up period was 22 months(6-30 months),in the observation group,there was 1 case of local flap ischemia but no necrosis at the early stage.There were 2 cases of local flap ischemic necrosis in the control group,it had no local recurrence and distant metastasis occurred in all the patients.There was no statistical difference in cosmetic effect between the two groups　(P>0.05).Conclusion For breast cancer patients with tumor located in the lower pole,the tumor shaping method of crescent incision combined with abdominal advancement flap applied reasonably can achieve a good aesthetic effect.It is a simple and feasible procedure and it is worthy of promotion.
2018 Vol. 25 (17): 75-77 [Abstract] ( 143 ) HTML (33 KB)  PDF  (0 KB)  ( 28 )
78 Effect of esophageal stent im plantation treating advanced esophageal cancer
LU Xin-peng；　GUO Fan-wei
ObjectiveTo investigate the effect of esophageal stent implantation treating advanced esophageal cancer.MethodsThe clinical data of 82 patients with advanced esophageal cancer admitted into our hospital from January 2013 to January 2016 were retrospectively analyzed.According to different treatment methods,they were divided into the observation group(n=41)and control group(n=41).In the control group,patients were treated with conventional chemotherapy,while in the observation group,patients were given esophageal stent implantation.The improvement of dysphagia before and after treatment,patients′polypnea index and score of nutritional status,quality of life score(SF-36),patient′s satisfaction rate for treatment,and 1 year and 2 years survival rate were compared between the two groups.ResultsBefore treatment,there was no significant difference in dysphagia between the two groups(P>0.05).After treatment,dysphagia was improved in both groups,and the improvement in the observation group was better than that of the control group　(P<0.05).The polypnea index,score of nutritional status,and SF-36 score in the observation group were all superior to those in the control group　(P<0.05).The satisfaction rate for treatment in the observation group was 97.56%,which was higher than that in the control group(80.49%).1 year and 2 years survival rate was 95.12%and 90.24%respectively,which was higher than that of the control group(78.05%and 70.73%respectively)(P<0.05).ConclusionThe effect of esophageal stent implantation treating advanced esophageal cancer is good.It can improve the dysphagia symptoms and nutritional status,improve the quality of life and the satisfaction rate for treatment in patients.It is worthy of further clinical study and application in clinic.
2018 Vol. 25 (17): 78-80 [Abstract] ( 142 ) HTML (33 KB)  PDF  (0 KB)  ( 33 )
81 Clinical effect of three-dimensional conformal radiotherapy combined w ith concurrent chemotherapy for the treatment of m iddle and advanced esophageal cancer
LIN Jia；　WANG Ji-yu；　XU Hong-wei
ObjectiveTo explore the clinical effect of three-dimensional conformal radiotherapy combined with concurrent chemotherapy for the treatment of middle and advanced esophageal cancer.MethodsForty-five patients with middle and advanced esophageal cancer admitted into our hospital from March 2016 to June 2017 were selected.They were divided into the control group　(n=23)and observation group　(n=22)according to an envelope randomization grouping method.Three-dimensional conformal radiotherapy was performed in the control group,while in the observation group,three-dimensional conformal radiotherapy combined with concurrent chemotherapy was adopted.The short-term and long-term efficacy,adverse reactions,survival rate,and survival time of the two groups after the corresponding treatment were observed.ResultsIn the observation group,the short-term and long-term total effectiveness rate was 95.45%and 90.91%respectively and 3-month and 6-mongh survival rate was 95.45%and 81.82%respectively in the observation group,which was higher than that in the control group respectively,and the incidence of adverse reactions was 9.09%in the observation group,which was lower than that in the control group,and the survival time was(19.85±5.34)months,which was longer than that in the control group　(P<0.05).ConclusionThree-dimensional conformal radiotherapy combined with concurrent chemotherapy is obvious in middle and advanced esophageal cancer and can prolong survival time.
2018 Vol. 25 (17): 81-83 [Abstract] ( 155 ) HTML (32 KB)  PDF  (0 KB)  ( 30 )
84 Effect of laparoscopic radical hysterectom y treating early-stage cervical cancer
ZENG Wei-hong ；YANG Hai-kun；　HUANG Li-shan
ObjectiveTo laparoscopic radical hysterectomy　(LRH)treating early-stage cervical cancer.MethodsAll of 120 patients with early-stage cervical cancer treated in our hospital from December 2013 to March 2018 were selected and they were divided into the study group　(60 cases)and control group　(60 cases)according to the different surgical approach.Patients in the study group were treated with LRH and patients in the control group were treated with open radical hysterectomy(ORH).The surgery efficacy,postoperative recovery,complications and FACT-G score of cancer patients were compared between the two groups.ResultsThe operation time of the study group was longer than that of the control group,and the bleeding volume during operation was fewer than that of the control group,and the number of lymph nodes dissection in the study group was significantly more than that in the control group(P=0.000).There was no significant difference in the length of excisional vaginal wall between the two groups(P=0.654).The postoperative exhaust,defecation time,indwelling catheter and hospitalization time in the study group were significantly shorter than those in the control group　(P=0.000),and the total incidence of postoperative complications was significantly lower than that of the control group(P=0.024).There was no significant difference in FACT-G scores between the two groups(P>0.05).Compared with before operation,FACT-G score of the two groups were significantly higher than those before operation(P=0.000),and FACT-G score of the study group was significantly higher than that of the control group(P=0.000).ConclusionLRH treating early-stage cervical cancer has a better effect with faster postoperative recovery and fewer complications,which is helpful to improve the quality of life of patients after operation.
2018 Vol. 25 (17): 84-86 [Abstract] ( 152 ) HTML (34 KB)  PDF  (0 KB)  ( 33 )
87 Study on the effects of metabolic syndrome during pregnancy on maternal and infantile lipid metabolism
LI Xiu-ming；JI Jia-fen；LIU Chang-yun；ZHU Hai-ling；ZHANG Qi；ZHAI Yu-ping；ZHENG Yang
ObjectiveTo study the effects of metabolic syndrome during pregnancy on lipid metabolism in pregnant women and the effects on the early lipid metabolism in their offspring.MethodsA total of 40 pregnant women who were hospitalized and gave delivery in the department of obstetrics in the Affiliated Hospital of Weifang Medical University from May 2016 to May 2017 were selected.Among them,20 cases of the pregnant women with metabolic syndrome in pregnancy and 20 offsprings of theirs were assigned to the study groups.20 healthy pregnant women and their offsprings were assigned to the control groups.The levels of apolipoprotein E,adiponectinand leptin in the serum of pregnancy women were measured respectively.At the same time,the correlation analysis between the above three components in the umbilical cord serum of the offspring were carried out.ResultsApolipoprotein E was　(490.15±90.76)ng/ml and leptin was(4.92±1.00)ng/ml in the pregnancy women in the study group.The Apolipoprotein was(576.95±83.37)ng/ml and leptin was　(3.16±1.18)ng/ml in their offsprings,which were all higher than those in the control group for pregnant women,apolipoprotein E and leptin were(389.51±69.37)ng/ml and(3.83±0.52)ng/ml respectively,and for the offsprings,the apolipoprotein E and leptin were(400.38±57.25)ng/ml and(2.29±1.01)ng/ml respectively;adiponectin was(4.76±1.19)ng/ml in the pregnancy women in the study group,and adiponectin was(4.29±1.34)ng/ml in their offsprings,which were both lower than those in the control group(adiponectin was[7.63±2.77]ng/ml in the pregnant women,and the adiponectin was　[6.32±1.97]ng/ml in the offsprings).The differences were statistically significant(P<0.05).ConclusionMetabolic syndrome during pregnancy leads to abnormal lipid metabolism in pregnant women and affects early lipid metabolism in the offsprings,which increases the risk of future metabolic syndrome in the offsprings.
2018 Vol. 25 (17): 87-89 [Abstract] ( 120 ) HTML (33 KB)  PDF  (0 KB)  ( 38 )
90 Influence on anti-mullerian hormone by different operation methods under laparoscope in treatment of salpingocyesis
CHEN Yu-ge ；MENG Jun； HUANG Shu-feng ；ZHUANG Yan； WU Yan-ling
ObjectiveTo study the influence on anti-mullerian hormone　(AMH)with different operation methods under laparoscope in treatment of salpingoeyesis.MethodsA total of 60 patients with tubal pregnancy from January 2015 to January 2017 were randomly divided into three groups with 20 cases in each group.For GroupⅠ,the monopolar electrical hook was adopted to eliminate the side fallopian tube with coagulation.For groupⅡ,the fallopian tube was ligated two times from the umbrella end to the cornual membrane near the isthmus using on DEXON thread before removing the fallopian tube.For groupⅢ,the lateral fallopian tube was resected after the tubal mesangial membrane was bipolar electrocoagulated.The radio-immunity method was employed to monitor the level of AMH and antral follicle count(AFC)in the affected side in the preoperative and 1,3 and 6 months postoperative periods.Through statistical analysis and comparison,the impacts to the ovarian reserve function due to different operation methods of fallopian tubal resection were observed.Results①The levels of AMH were in normal range before and after the operation.②there was no significant difference(P＞0.05)between preoperative AMH and AFC within the group ofⅠ,Ⅱ and Ⅲ before the operation.③In the 1 month after surgery,AMH and AFC all declined in groupⅠ,Ⅱ and Ⅲ,while AMH and AFC in group Ⅱdecreased significantly the difference were statistically significant(P<0.05).④In each time point after surgery,AMH and AFC of three groups,after surgery 3,6 months with compared before surgery,was not statistically significant(P＞0.05).ConclusionThree types of tubal resection of laparoscopic tube may have certain effects on the function of the ovary,with the ligation and resection method having a slightly greater impact on the ovarian reserve function.
2018 Vol. 25 (17): 90-92转96 [Abstract] ( 121 ) HTML (35 KB)  PDF  (0 KB)  ( 33 )
93 Comparative study on the effect of heel sam pling for newborn disease screening in two kinds of postures
LAN Xiu-xiu；　CHEN Xiao-jiao
ObjectiveA comparative study of the effects of screening for heel blood in neonatal disease screening under two postures.MethodsA total of 200 healthy newborns born in our hospital from October 2016 to October 2017 were randomly selected.All newborns were screened for heel blood collection disease.According to the random number table method，they were divided into control group　(n=100)and observation group　(n=100).The control group was used the traditional heel blood supine position,the observation group was used arms make a head low to high neonatal heel blood collection,analysis of the two groups of blood collection results.ResultsThe blood spot diameter of the observation group was greater than that of the control group,and the blood collection time was shorter than that of the control group,with a significant difference(P<0.05).The success rate of blood sampling in the observation group was higher than that in the control group.The incidence of heel blood stasis was lower in the observation group than in the control group.The heel pressure was lesser than that in the control group,and the differences were statistically significant(P<0.05).The puncture heart rate of the observation group was lower than that of the control group,and the oxygen saturation was higher than that of the control group,with a significant difference(P<0.05).The limb movement,facial expression pain scores,voice performance pain of the observation group were all lower than those of the control group(P<0.05).ConclusionIn the screening of neonatal diseases heel blood collection.the use of hand-wounding method makes the neonatal head high and low position blood collection effect is good,and the clinical application value is higher.
2018 Vol. 25 (17): 93-96 [Abstract] ( 124 ) HTML (37 KB)  PDF  (0 KB)  ( 28 )
97 Analysis of cesarean section rates and indications of cesarean section in our hospital ranging from M arch,2010 to July,2014 and its influencing factors
ZHANG Rong
ObjectiveTo analyze the changes of cesarean section rates and indications of cesarean section in our hospital and to explore its influencing factors in order to promote the reasonability and standardability of cesarean section.MethodsThe clinical data of cesarean section women from March 2010 to July 2014 were retrospectively analyzed.The maternal delivery mode and cesarean section indications were collected.The proportions of different modes of delivery and various surgical indications were calculated.ResultsCesarean section rates in our hospital from March 2010 to July 2014 was 62.30%,63.43%,56.42%,50.91%,and 58.21%respectively.The cesarean section rate was in a downward trend(χ2=119.644,P<0.01).The vaginal delivery rate during 2010-2014 was 37.67%,36.29%,43.58%,49.09%,and 41.79%respectively.The vaginal delivery rate showed an inclination of increase(P<0.01).The first three indications of cesarean section after analysis in our hospital from 2010 to 2014 were head presentation dystocia,fetal distress,and abnormal fetal position.The proportions of scar uterus and abnormal pelvic were elevating.The percentages of head presentation dystocia,abnormal stages of labor,and social factors were in a tendency of decrease.ConclusionThe cesarean section rate in our hospital has been declining year by year.Its influencing factors are related to social,medical,and economic factors etc.Clinicians should effectively control the indications of cesarean section and reduce the interference of nonmedical factors on the choice of delivery mode in order to control the cesarean section rate in a reasonable range,and improve the diagnosis of obstetric staff and midwifery techniques.
2018 Vol. 25 (17): 97-99 [Abstract] ( 119 ) HTML (30 KB)  PDF  (0 KB)  ( 32 )
100 The effect of early contact，early sucking on lactation of prim ipara and health of the newborn
GU Cong-hui； LUO Qiu-xia；　MU Ying-ying；　WU Xiao-xiao　；WU Xiu-na
ObjectiveTo research the effect of early contact,early sucking on lactation of primipara and health of the newborn.MethodsFrom June 2016 to September 2017,the clinical data of 145 cases of primipara who were successfully delivered in obstetrics department of our hospital were analyzed retrospectively.According to whether or not to accept the postpartum early contactearly sucking,primiparas were divided into the observation group(76 cases)and the control group(69 cases).The observation group carried out early contact and early sucking after postpartum,while the control group did not carry out early contact and early sucking after postpartum.The lactation and neonatal status of the two groups of primipara were compared.ResultsThe colostrum secretion time and the filling time of postpartum breast in the observation group were significantly lower than in the control group,the number of 24 h lactation after postpartum was significantly more than that of the control group(P<0.05).In the observation group,the distribution lactating amount of 0-48 h and＞48-72 h in postpartum women were significantly better than those of the control group,and the differences were statistically significant(P<0.05).The incidence of neonatal complications in the observation group was 9.21%,which was significantly lower than that of the control group(36.23%),and the difference was statistically significant(P<0.05).ConclusionThe primipara who carry out the early postpartum,early sucking,the colostrum is secreted earlier,and the amount of lactation is more.It can satisfy the newborn′s breast milk supply at the early stage of postpartum,so that the success rate of breastfeeding is further improved,which is very beneficial for the health of the newborn and the newborn.
2018 Vol. 25 (17): 100-102转106 [Abstract] ( 126 ) HTML (34 KB)  PDF  (0 KB)  ( 23 )
103 App lication effect of Bakri uterine tam ponade w ith balloon catheter in treatment of postpartum hemorrhage after cesarean section
BAI Zhi； LONG Da-jian；　CHI Hao；　YANG Ming；　CHEN Min-hong；　LIU Zhuan-qin；　HE Ya-ting；　JI Yan-jie
ObjectiveTo explore the application of Bakri uterine tamponade with balloon catheter in prevention of postpartum hemorrhage.MethodsAll of 152 patients suffered from postpartum hemorrhage after cesarean section admitted into our hospital from January 2015 to January 2018 were randomly divided into control group and study group,76 cases in each group.In the control group,conventional basic uterine contraction therapy and local suturing for bleeding were used,while in the study group,Bakri uterine tamponade with balloon catheter intervention on the basis of the control group was added.The post-natal 24-hour bleeding,preoperative and postoperative hemoglobin changes,hospital stay,hospital costs,lochia duration,and hysterectomy rate in both groups were observed.ResultsIn the study group,the post-natal 24-hour blood loss,hemoglobin change was lesser than that in the control group,hospital stay,and duration of lochia were shcrter than that in the control group,hospitalization cost was significantly lower than those in the control group with statistical significance(P<0.05).The hysterectomy rate was 0.0%in the study group,lesser than that in the control group accounting for 0.3%with a significant difference(P<0.05).ConclusionThe Bakri uterine tamponade with balloon catheter can be used to prevent postpartum hemorrhage.The method is simple and obtain a rapid hemostasis,which can be used in clinic.
2018 Vol. 25 (17): 103-106 [Abstract] ( 153 ) HTML (39 KB)  PDF  (0 KB)  ( 27 )
107 Influence of subclinical hypothyroidism during pregnancy on pregnancy outcome
LI Xiao-ling；　DENG Shan；　DENG Qing-hua
ObjectiveTo investigate the effect of subclinical hypothyroidism during pregnancy on pregnancy outcome.MethodsNinety cases of pregnancy with subclinical hypothyroidism(SCH)in our hospital from June 2015 to June 2017 were selected as the observation group.At the same time,95 cases of healthy pregnant women were selected as the control group.Two groups of maternal serum samples were collected respectively.Serum free thyroxine　(FT4),thyroid stimulating hormone　(TSH)and thyroid peroxidase antibody　(TPOAB)levels in serum were detected by chemiluminescence immunoassay.And give the corresponding treatment.ResultsThe incidence of pregnancy induced hypertension,premature rupture of membranes,postpartum hemorrhage and anemia in the observation group was significantly higher than that in the control group,the differences were statistically significant(P<0.05).There were no significant difference in the incidence of gestational diabetes,intrahepatic cholestasis,abortion,and hypoproteinemia in the two groups　(P＞0.05).The incidence of fetal intrauterine distress and fetal intrauterine growth restriction in the observation group was significantly higher than that in the control group,with a significant difference　(P<0.05).There were no significant difference in the incidence of low birth weight infants,fetal malformation and neonatal asphyxia in the two groups　(P＞0.05).ConclusionSubclinical hypothyroidism of pregnancy has an obvious adverse effect on pregnancy outcome,and corresponding clinical intervention should be carried out to reduce the result of bad pregnancy.
2018 Vol. 25 (17): 107-109 [Abstract] ( 136 ) HTML (32 KB)  PDF  (0 KB)  ( 37 )
110 Clinical effect of hemostatic wound healing gauze in the treatment of oral mucosal ulcer
ZHANG Yi-xuan;HANG Jing;ANG Lei;HANG Wen-jun
ObjectiveTo discuss the clinical effect of hemostatic wound healing gauze　(carboxymethyl chitosan)in the treatment of traumatic oral mucosal ulcer.MethodsFrom August 2015 to October 2017,84 patients with oral ulcers caused by various types of wounds in outpatient clinic of stomatology in our hospital were selected as the subject,and randomly divided into observation group and control group,with 42 cases in each group.In the observation group,hemostatic wound healing gauze was used,while in the control group,mirabilitum praeparatum spray was adopted.After treatment,time for pain relieving was observed.The time of wound edema disappeared on the 3rdand 7thday after treatment was observed as well as the effect of wound healing and repairing.The adverse reactions were recorded and evaluated.ResultsThe effective time of pain relieving in the observation group was significantly shorter than that in the control group　(P<0.05).The disappearance time of wound edema in the observation group was much shorter than that in the control group(P<0.05).The cure rate on the 7thday in the observation group was 95.2%,significantly higher than that in the control group accounting for 64.3%　(P<0.05).There was no significant difference in safety between the two groups(P>0.05).ConclusionHemostatic wound healing gauze in the treatment of traumatic oral mucosal ulcers obtains effect of pain relieving and ulcer healing promotion in good safety,which is worthy of clinical promotion and application.
2018 Vol. 25 (17): 110-112 [Abstract] ( 133 ) HTML (35 KB)  PDF  (0 KB)  ( 27 )
113 Effect of Com pound Huangqin M outhwash in the treatment of bacteriainfected stomatitis
WAN Qian
ObjectiveTo investigate the effect of Compound Huangqin Mouthwash in the treatment of bacteria-infected stomatitis.MethodsFrom September 2016 to September 2017,84 patients with bacteria-infected stomatitis who were admitted to the department of stomatology in our hospital were selected as the subject.According to the random number table method,the patients were divided into two groups,with 42 patients in each group.The control group was given nystatin tablets,and the observation group was given Compound Huangqin Mouthwash on the basis of this.The oral condition,NRS score and satisfaction were compared and observed between the two groups.ResultsThe number of oral microbes in the observation group was less than that in the control group,the situation of stomatitis after treatment was better than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in NRS scores before treatment between the two groups(P>0.05).After treatment,the NRS score in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).The total satisfaction in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).ConclusionThe application of Compound Huangqin Mouthwash in the treatment of stomatitis can achieve a favorable therapeutic effect,improve the patient′s pain index,and improve patients′satisfaction.
2018 Vol. 25 (17): 113-115 [Abstract] ( 123 ) HTML (33 KB)  PDF  (0 KB)  ( 35 )
116 Analysis of the influence of gingival and alveolar ridge dressing on the restoration of dental
YE Bo-yang;　TANG Zi-ming;　LIAO Shi-fen
ObjectiveTo study the influence of gingival and alveolar ridge repair on the restoration of teeth.MethodsSixty-eight patients with dental restoration treated in our hospital from February 2015 to January 2016 were selected as the research object.According to the random number table,they were divided into control group and intervention group,34 cases in each group.The control group was treated with traditional dental restoration surgery.The intervention group was given gingival and alveolar ridge dressing surgery prior to dental restoration surgery.The aesthetics score,dental stability,masticatory function,dental comfort level,total effective rate of dental restoration,incidence of adverse events after dental restoration,and the quality of life scores of patients before and after the repair were compared between the two groups.ResultsThe total effective rate of dental restoration in the intervention group was higher than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse events in the intervention group was significantly lower than that of the control group after dental restoration,the difference was statistically significant(P<0.05).The scores of aesthetic appearance,dental stability,chewing function and dental comfort in the intervention group were significantly better than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in quality of life scores before intervention　(P>0.05).After intervention,each quality of life factor score of the intervention group was better than those of the control group,the differences were statistically significant(P<0.05).ConclusionGingival and alveolar ridge dressing has a great effect on dental restoration,which can effectively improve the aesthetic appearance,dental stability,dental comfort,improve the masticatory function,and improve the quality of life of patients and reduce the occurrence of adverse events,which deserves promotion and application.
2018 Vol. 25 (17): 116-118 [Abstract] ( 121 ) HTML (32 KB)  PDF  (0 KB)  ( 33 )
119 The clinical effect of eustachian tube balloon dilatation and tympanic membrane incision catheter in the treatment of refractory otitis media
LI Hao ;SUN Qun;　WANG Qiong; CHEN Qi-guo ;LI Xiao-hu
ObjectiveTo study and discuss the clinical effect of eustachian tube balloon dilatation combined with tympanic membrane incision catheter in the treatment of refractory otitis media with effusion.MethodsFrom January 2015 to June 2017,60 cases of patients with refractory secretory otitis media treated in our hospital were selected and divided into two groups by random number table method,30 cases in each group.The control group was treated by simple tympanic membrane incision catheter,the observation group was treated by tympanic membrane incision catheter combined with eustachian tube balloon dilatation.The patients were followed up for 6 months,the clinical effects,pure audiometry,eustachian tube pressure and pain score were compared between the two groups.ResultsThe total effective rate in the observation group was 93.33%,the control group was 73.33%,there was statistically significant between the two groups　(P<0.05).After treatment,the pure tone audiometry in the observation group was higher than that in the control group　(P<0.05),eustachian tube pressure and pain scores in the observation group were lower than that in the control group,the difference was statistically significant　(P<0.05).ConclusionTympanic membrane incision catheter combined with eustachian tube balloon dilatation can be used to treat patients with refractory otitis media with effusion,which can effectively improve hearing and relieve pressure and pain of eustachian tube,it has significant effect.
2018 Vol. 25 (17): 119-121 [Abstract] ( 122 ) HTML (34 KB)  PDF  (0 KB)  ( 29 )
122 Effect of different surgical methods in the treatment of cataract
SUN Meng；YANG Bing；YU Wen-han
ObjectiveTo explore the effect of different surgical methods in the treatment of cataract.MethodsFrom October 2015 to October 2016,175 cataract patients treated in Mudanjiang Aier Ophthalmology Hospital and the First Branch of Hongqi Hospital Affiliated to Mudanjiang Medical University were selected as the subjects,and divided into ultrasonic group(86 cases)and non-ultrasound group(89 cases)according to the willing of patients.Ultrasonic emulsification was adopted in patients with ultrasound group,and the patients with non ultrasonic group were treated with small incision and non phacoemulsification.The recovery of visual acuity,astigmatism,the number of corneal endothelial cells and the incidence of postoperative complications were compared between the two groups.ResultsThe recovery of visual acuity in patients of non-ultrasound group at 1stwas better than that in the ultrasound group.The incidence rate of corneal edema and rupture of suspension ligament of non-ultrasound group was lower than that in ultrasound group,the difference was statistically significant(P<0.05).ConclusionSmall incision and non phacoemulsification have better postoperative rehabilitation,and effectively reduce the incidence of postoperative complications.
2018 Vol. 25 (17): 122-124 [Abstract] ( 102 ) HTML (32 KB)  PDF  (0 KB)  ( 28 )
125 Clinical effect of rigid ear endoscopic tympanoplasty in the treatment of secretory otitis media
CAO Run-qin
ObjectiveTo investigate the clinical effect of tympanostomy with rigid ear endoscopy in the treatment of secretory otitis media.MethodsForty-eight patients with secretory otitis media admitted from January 2017 to January 2018 in our department were selected as the subject,and randomly divided into the control group and the observation group,with 24 cases in each group.Twenty-four patients in the control group were treated by conventional tympanostomy.Twenty-four patients in the observation group were treated by rigid endoscopic tympanoplasty.The treatment effects,operational satisfaction and adverse reactions were compared between the two groups.ResultsThe total effective rate of the observation group was 91.7%,while the total effective rate of the control group was 79.2%,the difference was statistically significant(P<0.05).The satisfaction degree of the observation group was 87.5%,which was significantly higher than that of the control group(70.8%),the difference was statistically significant(P<0.05).Zero case of the external auditory canal mucosal bleeding,1 case of tympanic membrane hemorrhage,1 case of ear pain were observed in the observation group,the adverse reaction rate was 8.3%.There were 2 cases of tympanic membrane hemorrhage in the control group,1 case of the external auditory canal mucosal bleeding,2 cases of ear pain,the adverse reaction rate was 20.8%,the difference was statistically significant(P<0.05).ConclusionFor the cases of secretory otitis media treated in otolaryngology clinic,rigid ear endoscopic tympanic membrane puncture is used to treat patients.Compared with conventional tympanostomy,the therapeutic effect and operation satisfaction of the patients can be significantly improved,and the risk of thetympanic membrane and mucosa of the external auditory canal can be significantly reduced.It can prevent pain and other adverse reactions.Furthermore,its value of the prognosis is significant.
2018 Vol. 25 (17): 125-127 [Abstract] ( 108 ) HTML (33 KB)  PDF  (0 KB)  ( 32 )
128 Effect of orthodontic treatment in bracketless app liance and traditional fixed appliance and com parison of periodontal health
LI Hong；　LU Ying-jie；　LIANG Jing
ObjectiveTo investigate the effect of orthodontic treatment in bracketless appliance or traditional fixed appliance and comparison of periodontal health.MethodsFrom January 2016 to June 2017,40 patients accepted orthodontic treatment in Department of Dentistry of our hospital were selected as the subject,and divided into research group and control group by odd or even number of their enrollment sequency,20 cases in each group.In the control group,patients were treated with straight wire bow bracket every day.In the research group,following the design protocol for clinical correction,the transparent bracket-free appliance for dental jaw model was created via a three-dimensional rapid laser in each stage of orthodontic treatment.The orthodontic treatment effect,dental arch width,gingival index(GI),and plaque index　(PLI)were compared between the two groups.ResultsAfter treatment,the U1-NA angle,L1-NB angle,and the length of anterior segment of the dental arch in the research group were all significantly higher than those in the control group,and L1-NB angle was lower than that in the control group,the difference was statistically significant(P<0.05).In the research group,the scores of GI and PLI scores at the 16thweek were significantly lower than those in the control group,the difference was statistically significant(P<0.05).ConclusionCompared with the traditional fixed appliance,the orthodontic treatment in bracketless appliance can better reduce the height of the posterior teeth,prevent the tilting of the front teeth in an excellent curative effect,and have more healthy mouth and gums.
2018 Vol. 25 (17): 128-130 [Abstract] ( 117 ) HTML (34 KB)  PDF  (0 KB)  ( 23 )
131 Application of Dexmedetom idine combination w ith Dezocine in awake intubation guided by dioscorea
CHEN Wen-jia；　JIANG Lin；　SUN Can-lin
ObjectiveTo investigate the effects of Dexmedetomidine combined with Dezocine for application of awake intubation guided by disposcope endoscope.MethodsFrom August 2017 to January 2018,40 patients required intubation in our hospital were randomly divided into group A and B.Group A was treated intravenous injection of Midazolam and Sufentanil;group B was treated intravenous infusion of Dexmedetomidine,intravenous injection of Dezocine.The MAP and HR were recorded.,and the recording time was 4 times in operation room(T0),before intubation(T1),after tracheal intubation(T2)and 10 min after extubation(T3),using Ramsay Score,intubation tolerance score satisfaction score to evaluate intubation process and,the number of patients with respiratory depression was recorded.ResultsAll of the 40 patients were successfully intubated.The score of Ramsay in group B was superior to that of group A at T3(P<0.05).MAP and HR of both groups were decreased after treatment,with statistical difference at T1and T2,while group B(P<0.05).At T3,the HR of group B was lower than that of group A　(P<0.05),and the satisfaction of group B was better than that of group A　(P<0.05).And no patients with respiratory depression in group B.ConclusionWith the application of Dexmedetomidine combined with Dezocine,in the process of intubation and extubation in patients with more stable hemodynamics;patients with sedative effect and higher satisfaction;it is worthy of clinical application.
2018 Vol. 25 (17): 131-133转136 [Abstract] ( 133 ) HTML (40 KB)  PDF  (0 KB)  ( 37 )
134 Effect com parison of Lidocaine and Atenaine in mandibular molar irreversible pulpitis anesthesia
SU Ru-yi
ObjectiveTo analyze the effects of Lidocaine and Articaine on mandibular molars irreversible pulpitis anesthesia of mandibular molars.MethodsFrom January 2013 to December 2016,96 patients with irreversible pulpitis of mandibular molars underwent pulpotomy in our hospital were selected and randomly divided into the Lidocaine group and the Articaine group,48 patients in each group.In the anesthesia of alveolar nerve infiltration,2%Lidocaine＋1∶100 000 adrenaline was used for nerve block anesthesia and 4%altecaine＋1∶100 000 adrenaline was used for nerve block anesthesia,respectively.The anaesthetic onset time,intraoperative and postoperative VAS pain scores,and satisfaction degree with surgical anesthesia were recorded and observed between the two groups.The difference in anesthetic effects between the two anesthesia methods was compared.ResultsThe time of onset of intraoperative and postoperative anesthesia in the Articaine group was shorter than that in the Lidocaine group　(P＜0.05),the pain score in the Articaine group was significantly lower than that in the Lidocaine group　(P＜0.05),the satisfaction rate of anesthesia effect in the Articaine group was significantly higher than that in the Lidocaine group(P＜0.05).ConclusionIn the case of mandibular molar irreversible pulpitis requiring endodontic surgery,selective use of Articaine for local anesthesia can shorten the onset time of anesthesia,the effect is significant.
2018 Vol. 25 (17): 134-136 [Abstract] ( 122 ) HTML (31 KB)  PDF  (0 KB)  ( 32 )
137 Clinical effect of sublingual Captopril on the emergency treatment of hypertension
CHEN Jian；　LAI Hai-Bo；　CUI Yu-Ting
ObjectiveTo study and investigate the clinical effect of sublingual Captopril on the emergency treatment of hypertension.MethodsA total of 100 hypertensive patients treated in department of emergency in our hospital from January 2015 to December 2017 were selected as subjects and divided into two groups according to the random number table method in the computer,50 cases in each group.The control group was treated with Amlodipine orally,and the observation group was given sublingual therapy with Captopril on the basis of Amlodipine treatment.The blood pressure level,onset time of lowering blood pressure and the occurrence of adverse reactions were compared between the two groups.ResultsBefore treatment,there was no significant difference in systolic and diastolic pressure between groups(P>0.05).After treatment,the systolic pressure and diastolic pressure in the two groups were significantly lower than those before the treatment,the differences were statistically significant(P<0.05),while the systolic and diastolic pressure in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The onset time of lowering blood pressure in the observation group was(9.86±2.35)min,which was shorter than that in the control group of(12.75±2.81)min,the difference was statistically significant(P<0.05).The total incidence of adverse reactions was 8%in the observation group,which was 6%in the control group,and the total incidence of adverse reactions in the two groups was not statistically significant(P>0.05).ConclusionDuring the emergency treatment of hypertension,the treatment method of sublingual Captopril can promote the decrease of blood pressure as soon as possible,improve the effect of blood pressure control,and it is safe and reliable,and will not increase the risk of adverse drug reaction.
2018 Vol. 25 (17): 137-139 [Abstract] ( 127 ) HTML (33 KB)  PDF  (0 KB)  ( 23 )
140 Effect com parison of Omeprazole and Ranitidine on gastric ulcer
LU Tian-yu；　GONG Mei-jin；　ZHENG Yi

ObjectiveTo compare the effect of Omeprazole and Ranitidine on gastric ulcer.MethodsFrom October 11,2016 to October 11,2017,a total of 140 patients with gastric ulcer treated in our hospital were selected as study subjects.According to an odd or even number method,they were divided into two groups,70 cases in each group.In the odd number group,patients were treated with Ranitidine Hydrochloride　(as Ranitidine group),and the other patients with even number were provided with Omeprazole(as Omeprazole group).The total effectiveness rate,treatment time(effective time and cure time),and occurrence of adverse reactions in the two groups were compared and analyzed.Meanwhile,the changes of interleukin-2　(IL-2),IL-6,C-reactive protein　(CRP),vascular endothelial growth factor(VEGF)and epidermal growth factor　(EGF)before and after treatment were comarped and observed.ResultsThe total effectiveness rate of the Omeprazole group was 97.14%,which was higher than that of Ranitidine group accounting for 85.71%with a significant difference　(P<0.05).The therapeutic effectiveness time and cure time in the Omeprazole group were　(6.54±1.84)days and(18.55±4.23)days,shorter than those in the Ranitidine group of(15.41±3.22)days and(37.54±5.34)days respectively,which were displayed statistical significance　(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treament,in the Omeprazole group,the levels of IL-2,IL-6,and CRP were　(5.44±1.63)ng/L,(15.08±8.33)ng/L and　(2.11±1.12)mg/L,all lower than those in the Ranitidine group of(8.68±1.40)ng/L,(33.22±7.94)ng/L and　(4.26±1.15)mg/L,which were displayed statistical significance　(P<0.05).The values of VEGF and EGF in the Omeprazole group were(102.50±8.01)pg/L and(302.33±10.27)pg/L,higher than those in the Ranitidine group of(81.75±8.61)pg/L and(229.54±10.44)pg/L respectively,with significant differences(P<0.05).ConclusionOmeprazole has a significant effect on gastric ulcer,which can effectively ameliorate patients′inflammatory response,quickly repair the ulcer,and enhance the treatment effect,and has the value of recommended application.
2018 Vol. 25 (17): 140-142 [Abstract] ( 128 ) HTML (34 KB)  PDF  (0 KB)  ( 26 )
143 Effect of Nifedipine Sustained Release Tablets combined w ith Enalapril Tablets in the treatment of elderly patients w ith hypertension and coronary heart disease
QIN Su-ping
ObjectiveTo investigate the therapeutic effects of combination therapy on elderly patients with hypertension and coronary heart disease.MethodsTotally 76 elderly patients with hypertension and coronary heart disease who were treated in our hospital from July 2015 to May 2017 were selected as subjects of this study.The selected patients were randomly divided into experimental group and control group according to the random number table method,38 cases in each group.Patients in the control group were treated with Nifedipine Sustained Release Tablets only.Nifedipine Sustained Release Tablets combined with Enalapril Tablets were used in the experimental group.The total effective rate,systolic and diastolic blood pressure before and after treatment and incidence of adverse reactions during treatment were compared between the two groups.ResultsThe total effective rate in the experimental group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups(P>0.05).After treatment,the systolic and diastolic blood pressure were significantly lower than before treatment,and the systolic and diastolic blood pressure of patients in the experimental group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).ConclusionThe combined treatment of hypertension and coronary heart disease in elderly patients with significant effect,which can quickly stabilize patients with systolic and diastolic blood pressure,improve clinical symptoms,fewer adverse drug reactions,with the promotion of value.
2018 Vol. 25 (17): 143-145 [Abstract] ( 122 ) HTML (34 KB)  PDF  (0 KB)  ( 27 )
146 Influencing factors of the efficacy of the combination of Carboprost Trometham ine and Oxytocin in the treatment of postpartum hemorrhage after cesarean section
ZHAO Ya-ling
ObjectiveTo explore the influencing factors of the efficacy of the combination of Carboprost Tromethamine and Oxytocin in the treatmentofpostpartum hemorrhageaftercesarean section.MethodsA retrospectiveanalysisof140 cases of cesarean section postpartum hemorrhage treated with Carboprost Tromethamine combined with Oxytocin in Chang′an Hospital in Dongguan City of Guangdong Province from September 2015 to September 2017 were carried out.According to the effect of clinical treatment,the patients were divided into effective group(n=120)and ineffective group(n=20).Single factor descriptive analysis and multiple factor Logistic regression analysis of factors that may affect the efficacy of such patients treated with Carboprost Tromethamine and Oxytocin were determined.ResultsThe rates of age≥35 years old,uterine scar pregnancy,multi fetus,fetal distress,double or multiple births,placenta previa,gestational times>3 and small pelvis in the ineffective group were much higher than those in the effective group,the differences were statistically significant(χ2=23.770,61.920,21.672,9.047,4.543,7.426,15.084,P<0.05).The age ≥35 years old,uterine scar pregnancy,multi fetus,fetal distress,double or multiple births,placenta previa,gestational times>3 and small pelvis were independent risk factors affecting the efficacy by Logistic regression analysis(OR=12.475,19.643,11.120,5.407,4.144,4.071,6.745,P<0.05).ConclusionThe greater the age,the less effective the treatment of postpartum hemorrhage treated with Carboprost Tromethamine combined with Oxytocin,in addition,there are a variety of risk factors that are more common.In order to promote the rapid recovery of postpartum hemorrhage in caesarean section and guarantee the recovery of postpartum hemorrhage,the strategies of improving the curative effect should be formulated according to the analysis of the above risk factors.
2018 Vol. 25 (17): 146-148转155 [Abstract] ( 136 ) HTML (33 KB)  PDF  (0 KB)  ( 27 )
149 Clinical effect of Yiqi Huoxue,Dem pness and phlegm dissipating traditional Chinese medicine combined w ith Western medicine in treating the sequela of ischem ic cerebral apop lexy
LIN Xiao-ling
ObjectiveTo study the clinical effect of Yiqi Huoxue,Dempness and phlegm dissipating traditional Chinese medicine combined with Western medicine in treating the sequela of ischemic cerebral apoplexy.MethodsA total of 91 cases of ischemic stroke sequelae patients admitted to our hospital from October 2015 to October 2017 were randomly selected and divided into the observation group　(46 cases)and the control group　(45 cases).The control group was adopted the routine Western medicine treatment regimen,and the observation group was based on the treatment plan of Yiqi Huoxue and and comparing the clinical effects of the two groups.ResultsThe total effective rate was 89.13%,higher than 71.11%in the control group　(P＜0.05）.The total blood viscosity,plasma viscosity and fibrinogen content of the observation group were lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion yiqi huoxue approaches for the patients with ischemic cerebral apoplexy sequel,dampness and phlegm dissipatring combined Chinese traditional medicine western medicine treatment,effectively improve the efficiency of patients at the same time help to improve the liquidity,the blood is worth popularizing clinically，
2018 Vol. 25 (17): 149-151 [Abstract] ( 120 ) HTML (31 KB)  PDF  (0 KB)  ( 28 )
152 Clinical effect of Entecavir combined w ith Fuzheng Huayu Tablets in the treatment of liver cirrhosis com pensatory patients
CHEN Xing
ObjectiveTo investigate the clinical effect of Entecavir combined with Fuzheng Huayu Tablets in the treatment of decompensated hepatitis B patients.MethodsThe clinical data of 78 patients with decompensated hepatitis B from June 2015 to May 2016 in our hospital were retrospectively analyzed.The patients were divided into two groups(n=39)by random number table method.The patients in the control group were treated with Entecavir Dispersible Tablets.The patients in the treatment group were treated with Fuzheng Huayu Tablets on the basis of the control group.Both groups were treated for 1 year and were followed up for 3 months.The liver function indexes and serum liver fibrosis indexes were measured before and after treatment in both groups.The diameter of main portal vein and the spleen thickness before and after treatment were observed with abdominal ultrasonography.FibroScan was used to measure and record the liver cirrhosis(Stiffne value)before and after treatment.The negative rate of HBeAg and HBV DNA in both groups were calculated.The Child-Pugh scores and adverse reactions were compared between the two groups after treatment.ResultsThe indexes of ALT,AST,TBil,ALB and other indexes of serum liver fibrosis of HA,LN,PCⅢandⅣ-C in two groups after 1 year of treatment and 3 months of follow-up were significantly lower than those in the control group(P<0.05).After treatment,the above indexes in the treatment group were significantly better than those in the control group(P<0.05).The other two groups were significantly better than the treatment group before significantly reduced after treatment,the treatment group improved significantly better than the control group(P<0.05).The negative conversion rate of HBV DNA after treatment in treatment group was 89.74%,66.67%in control group,and Child-Pugh score was significantly lower than that in control group,the differences were statistically significant(P<0.05).But there was no statistical difference in the negative conversion rate of HBeAg between the two groups(P＞0.05).During the treament and after treatment of two groups,no serious adverse reactions occurred.ConclusionEntecavir combined with Fuzhenghuayu can significantly improve liver function in patients with decompensated hepatitis B and effectively inhibit or even reverse the progress of liver fibrosis.Compared with Entecavir alone,the clinical efficacy is better and the prognosis is more stable,which is worthy of clinical application.
2018 Vol. 25 (17): 152-155 [Abstract] ( 125 ) HTML (37 KB)  PDF  (0 KB)  ( 27 )
156 Analysis and study of individual voluntary unpaid donors
LIANG Jie-zhen； CHEN Cun-yi； CHEN Chao-hong ；LIANG Li-hua ；CHEN Zhi-zhong； QIU Yan-mei ；YU Wen-chao ；ZHANG Xin
ObjectiveTo understand individual voluntary donors′cognition for unpaid donation,the blood donation motivation and the information to blood donation,and the influence of the blood donation behavior of all kinds of people on the individual voluntary blood donors,providing scientific basis for improving the propaganda work of free blood donation in our city,establishment of an effective recruitment strategy for voluntary unpaid donors,taking effective propaganda to promote and recruit the target population,continue to expand the team of voluntary unpaid donors.MethodsThe database of voluntary voluntary blood donors from July 2015 to June 2017 were entered into the computer.A random survey of 1000 cases of individual donors was conducted by the way to take a questionnaire.Among them,760 cases were submitted with valid questionnaires,292 cases of first-time blood donors and 468 cases of again blood donors.The motivation and the knowledge of blood donation were compared between the first-time blood donors and the again blood donors.And the blood donors′access to blood donation information and the influence of various blood donors on the blood donors were investigated.ResultsThe main occupation of individual blood donors were self-employed businessmen,self-employed workers and peasants.There were more blood donors in the town than in the countryside,more men than women,and the blood donors were mainly young people under the age of 35.The blood donation motivation of"altruistic contribution"for the first-time blood donors and the again blood donors was the highest,and the difference was not statistically significant between the two group　(P>0.05).Among the first-time blood donors,the proportion of blood donation motivation of"want to know blood type or understand the condition of the body"was higher than that of the again blood donors,and the proportion of"to enjoy preferential blood policy"was lower than that of the again blood donors,the differences were statistically significant(P<0.05).The awareness of again blood donors in the knowledge of blood donation of"blood donation at a time","offer the composition difference of whole blood and blood","notes on the before and after blood donation"and"the main responsibility of voluntary blood donation"were higher than those of the first-time blood donors,the differences were statistically significant(P<0.05).The main channel of blood donation information for blood donors in our city was media publicity　(39.74%),followed by mobile blood donation vehicles　(or houses)(19.73%)and outdoor advertising(17.89%).Among blood donors,relatives and friends donate blood　(55.52%)most easily to persuade them to participate in blood donation.Relatives and friends,blood station staff and medical staff blood donationwould make blood donors more believe that blood donation was not harmful to health.ConclusionThe effective use of new media and the promotion of unpaid blood donation in rural areas can expand the publicity effect,achieve good results of recruitment.Attention should be paid to the propaganda of the blood donation activities of the medical staff or workers in blood station and the establishment of typical cases,as well as the activities for the blood donors to bring relatives and friends to participate in the organization of blood stations.It can encourage more people to join the blood donor team.
2018 Vol. 25 (17): 156-159 [Abstract] ( 136 ) HTML (39 KB)  PDF  (0 KB)  ( 27 )
160 Analysis on the demands and influencing factors of home care service for elderly patients with fracture
LIANG Qun-fei；ZHONG Lian-feng
ObjectiveTo explore the demands and influencing factors of home care service for elderly patients with fracture.MethodsWith the convenient sampling method,256 cases fracture patients treated in Luoding City Red Cross Hospital and Luoding People′s Hospital from April 2014 to August 2017 were selected as subjects.The self-designed elderly fracture home care needs questionnaire and modified Bathel index assessment were used to investigate the status of home nursing service demands and influencing factors for elderly patients with fracture.ResultsIn this study,there were 85.94%　(220/256)patients with varying degrees of daily self-care disability.The scores of life care,psychological spirit,health guidance,safety nursing,rehabilitation nursing and total demand of patients with different degrees of self-care were compared,and the differences were statistically significant(P<0.05).The results of multivariate Logistic regression analysis indicated that the degree of culture,marital status and economic income per capita were the important influencing factors for the demand of home care services for elderly patients with fracture(P<0.05).ConclusionThere is a large home care services demands of elderly patients with fracture in Luoding area.According to the demands of the elderly patients and provide personalized home care services,it is more conducive to the early recovery of patients and improve the quality of patients′life.
2018 Vol. 25 (17): 160-163 [Abstract] ( 126 ) HTML (35 KB)  PDF  (0 KB)  ( 36 )
164 Quality risk management study for vaccine cold chain transport
TIAN Su-xia
The vaccine transportation should ensure strict cold chain environment.The problems of cold chain will lead to serious product quality issue.In this paper,by applying the method of quality risk management,the various aspects of the vaccine cold chain transportation and identified the risks in the cold chain transportation were systematically evaluated.Mitigation actions for cold chain high risks were implemented,and the risks to acceptable level were effectively reduced to ensure the quality of the vaccine.
2018 Vol. 25 (17): 164-168 [Abstract] ( 110 ) HTML (36 KB)  PDF  (0 KB)  ( 31 )
169 Effect of applying the seam less care management mode in the emergency department on the transport of critical patients
ZHAO Run-mei ；LIANG Yi； MA Jian-kang ；ZHANG Fu-ling
ObjectiveTo investigate the effect of applying seamless care management in emergency department on the transport of critical patients.MethodsThe clinical data of 390 critical patients admitted to the emergency department in our hospital from July 2015 to June 2017 were analyzed.They were divided into the control group　(n=190)and the observation group(n=200)by random paper method.The control group was given regular care management,the observation group was given seamless care management.The probability of telephone-connections between departments,the probability of disputes on duties between the two handling parties,the probability of forgetting to hand over the patients,and the scores of handover time,transferring equipment,vital signs,and transferring valuable goods were observed in the two groups.ResultsThe probabilities of telephone-connections between departments,disputeson duties between the two handling parties,and forgetting to hand over the patients in the observation group were lower than that in the control group,the scores of observation time,transferring equipment,vital signs and valuable goods in the observation group were higher than that in the control group,with statistical significance(P＜0.05).ConclusionThe use of seamless care management in the emergency department to transfer critical patients can improve the transfer-handover efficiency and nursing satisfaction score by patients,which is worthy of clinical application and promotion.
2018 Vol. 25 (17): 169-171 [Abstract] ( 107 ) HTML (31 KB)  PDF  (0 KB)  ( 22 )
172 App lication of W eChat public p latform in operating room health education
ZHANG Jun-qiang；ZHANG Li；ZHOU Can；ZHAO Yuan-kun
ObjectiveTo explore the use of WeChat public platform in the operation room nursing health education.Methods200 patients relatives undergoing elective surgery in the operating room from July 2015 to February 2017 were selected as research objects.Patients relatives were randomly divided into control group and observation group according to the random number table method,100 cases in each group.The control group was adopted the traditional method of health education,the observation group was through the WeChat platform for health education.The knowledge of surgical knowledge and health education satisfaction were compared.ResultsThe score of medication knowledge,check knowledge,precautions and disease-related knowledge in observation group was higher than that in control group,with significant difference(P<0.05).The satisfaction of the content of health,the satisfaction of the educational form and the attitudes of the educators education in observation group was higher than that of the control group,the difference was statistically significant(P<0.05).ConclusionWe Chat public platform plays an active role in the operation and nursing health education.It can enhance the knowledge of patients′relatives in surgical knowledge and improve the satisfaction of health education,so it is worth further promotion.
2018 Vol. 25 (17): 172-174 [Abstract] ( 141 ) HTML (34 KB)  PDF  (0 KB)  ( 30 )
175 Application of holistic nursing in painless artificial abortion
LIAN Gui-xiang；JIANG Li-ping
ObjectiveTo evaluate the effect of holistic nursing in painless abortion.Methods58 patients with painless abortion who were admitted to our hospital from September 2016 to October 2017 were randomized.All patients were anesthetized with Propofol and Fentanyl,and were divided into controls group(n=29)and experimental group(n=29)according to the random number table method.The control group was treated with routine care and the experimental group was treated holistic care.The anesthetic effect,incidence of adverse reactions,heart rate and blood pressure,pain level,and nursing satisfaction were analyzed between two group.ResultsThe of good and excellent anesthetic effect and nursing satisfaction in the experimental group were significantly higher than those in the control group(P<0.05).The total incidence of adverse reactions and pain in the experimental group were significantly lower than those in the control group.The differences were statistically significant(P<0.05).The experimental group heart rate and blood pressure were significantly better than the control group,the differences were statistically significant(P<0.05).ConclusionIn the painless abortion propofol combined with fentanyl,the implementation of the overall care measures,significant care effect,can not only improve the anesthetic effect,improve blood pressure and heart rate in patients,but also reduce the incidence of adverse reactions,relieve pain，worthy of clinical application.
2018 Vol. 25 (17): 175-177 [Abstract] ( 123 ) HTML (35 KB)  PDF  (0 KB)  ( 27 )
178 Com parison of the app lication effect of psychological nursing in infertile patients at different cultural levels
MO Li-ping；　HUANG Xiao-lian
ObjectiveTo analyze and compare the application effect of psychological nursing on infertile patients at different cultural levels.MethodsA total of 120 patients with infertility who were admitted to our hospital from May 2016 to May 2017 were randomly selected as study subjects.According to different cultural levels,they were divided into the experimental group　(college degree or above),the observation group　(high school and junior middle school education)and the control group(primary school education),40 patients in each groups.All patients were treated with routine nursing and psychological nursing.The effect of nursing was analyzed and compared.ResultsThe negative psychology of the three groups after nursing was lower than that before nursing,and the difference was statistically significant(P＜0.05).The negative psychological score after nursing in the experimental group was significantly lower than that of the observation group and the control group,and the difference was statistically significant(P＜0.05).After nursing,family function scores and social adaptability scores of the three groups were higher than those before nursing,the difference was statistically significant(P＜0.05).The family function scores and social adaptability scores of the experimental group after nursing were significantly higher than those of the observation group and the control group,and the difference was statistically significant(P＜0.05).ConclusionIn the clinical nursing of patients with infertility,psychological nursing interventions for patients of different cultural levels can not only improve the negative psychology,but also improve the family function scores and social adaptability scores.The higher the cultural level,the better the nursing effect,with high clinical application value,it is worth promoting.
2018 Vol. 25 (17): 178-180转184 [Abstract] ( 109 ) HTML (36 KB)  PDF  (0 KB)  ( 29 )
181 Effect of high quality nursing intervention on health know ledge awareness and com pliance of schizophrenic patients
CHEN Ze-qun；JIANG Jian-mao；HUANG Ju-juan；CAO Yun-zhen
ObjectiveTo analyze the effect of high quality nursing on the level of knowledge of health knowledge and medication compliance in schizophrenia patients.MethodsProspective study was carried out,schizophrenic patients 124 cases in Guangzhou Civil Affairs Bureau Mental Hospital from Jaunary 2015 to October 2016,was divided into two groups by random number table method,62 cases in each group.The control group was received routine nursing and observation group was used high quality nursing.Before intervention,6 months and 12 months as the observation point,and the ITAQ score,health knowledge score and average compliance rate of each group were recorded.ResultsThe scores of ITAQ of the observation group at 6 months and 12 months after intervention were significantly higher than those of the control group respectively(P<0.05).The scores of health knowledge in the observation group were higher than those of the control group at 6 months and 12 months.The average compliance rate of the observation group at 6 months was(88.18±10.11)%,at 12 months was(90.01±9.21)%,which were significantly higher than those of the control group(P<0.05).The average compliance rate of the observation group at 12 months was higher than that before the intervention,the difference was statistically significant(P<0.05).But there was no statistical difference between the group and the 6 months(P＞0.05).ConclusionHigh quality nursing is used in the care of patients with schizophrenia,which can increase patient′s health knowledge and continually improve patient′s self-knowledge and attitude towards treatment,so as to ensure steady improvement of drug compliance in the near and long term.
2018 Vol. 25 (17): 181-184 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 29 )
185 Study on the influence of objective operation standard operating procedure on adverse events of elderly inpatients
ZHONG Li-Ying；　ZHANG Lin；　HUA Lian-ying；　PENG Rui-ying
ObjectiveTo study the effect of establishing standard operating procedure of nursing evaluation(SOP)on adverse events in elderly inpatients.MethodsAll of 160 elderly patients admitted to our hospital from January 2015 to December 2016 were selected as study subjects.From January to December 2015,76 patients treated with routine nursing evaluation were set up as control group,and from January to December 2016,84 patients treated with SOP were set up as experimental group.The patients in the two groups were observed to fall/fall in bed,inhaled/suffocated by mistake,and mistreated.Incidence of adverse events such as scalding,suicide,pressure sore,accidental extubation and satisfaction with nursing care.ResultsThe total incidence of adverse events such as falling/falling down bed,aspiration/asphyxia,medication error,scalding,suicide,pressure sore and accidental extubation in the experimental group were significantly lower than those in the control group.The differences were statistically significant(P<0.05),and the satisfaction degree of nursing service was significantly higher than that of the control group　(P<0.05.ConclusionThe establishment of SOP standard for nursing evaluation in elderly inpatients can effectively reduce the incidence of adverse events,ensure the safety of elderly patients,and improve the satisfaction of medical service.Degree is not only the practice standard of clinical nurses,but also the demand of the development of nursing discipline.
2018 Vol. 25 (17): 185-187 [Abstract] ( 125 ) HTML (31 KB)  PDF  (0 KB)  ( 25 )
188 Continuous nursing intervention improves the postoperative self-efficacy score and the effect of social support in patients w ith breast cancer
CHENG Cai-Ping；LI Shao-Fang；　LI Hua-xing；　SONG Li-xia；　HUANG Li-yun；　LAO Qi-jun
ObjectiveTo explore the effect of continuous nursing intervention on improving postoperative self-efficacy and social support of patients with breast cancer and to improve the cancer-induced fatigue in patients.MethodsSixtyfour patients with postoperative chemotherapy of breast cancer admitted from February 2015 to October 2017 in department of oncology of our hospital were divided into observation group and control group according to the random number table method,32 cases in each group.In the observation group,On the basis of the control group,the observation group was given continuous nursing intervention,the control group was given routine nursing intervention.The self-efficacy and social support scores of the two groups were compared to evaluate the effect of improving the cancer-induced fatigue in the two groups.ResultsAt 3 months and 6 months postoperatively,the scores of self-efficacy of the observation group were significantly higher than those of the control group(P<0.05);the scores of social support score,objective support and subjective support and support for utilization were higher than the control group,the differences were statistically significant(P<0.05);6 months after the observation group in behavior,emotion,feeling,cognition and total score were lower than the control group,The differences were statistically significant(P<0.05).ConclusionThe continuous nursing intervention after breast cancer patients can improve patient self-efficacy and social support,relieve symptoms of cancer-induced fatigue,it is worth clinical promotion.
2018 Vol. 25 (17): 188-190转193 [Abstract] ( 153 ) HTML (40 KB)  PDF  (0 KB)  ( 29 )
191 Effect of com fort nursing on pain control in patients with postoperative bone trauma
PAN Wen-xia； TAN Wen-yi； CHEN Xiu-bian
ObjectiveTo study the effect of comfort care in the pain control of patients with postoperative bone trauma.Methods80 cases of bone trauma in our hospital from February 2016 to February 2018 were selected.According to odd even number,they were divided into control group(40 cases)and observation group(40 cases).The control group bone trauma patients were given the conventional nursing mode,the observation group was given comfortable nursing for bone trauma patients,bone trauma patients postoperative pain scale score,quality of life score and nursing satisfaction were campared between two groups.ResultsThe VAS score of the observation group was lower than that of the control group on the first,second,third day after operation,and the differences were statistically significant(P<0.05).The indicators of quality of life in the observation group were all higher than those in the control group,the difference was statistically significant(P<0.05).The nursing satisfaction of the observation group(95.00%)was higher than that of the control group(67.50%),the difference was statistically significant(P<0.05).ConclusionComfortable nursing service has a significant effect on relieving postoperative pain in patients with bone trauma,and the pain is significantly reduced on the 3 day after operation,and the quality of life is guaranteed after operation.The satisfaction degree of patients with bone trauma is also improved.
2018 Vol. 25 (17): 191-193 [Abstract] ( 128 ) HTML (31 KB)  PDF  (0 KB)  ( 24 )
194 Observation on clinical nursing of infantile diarrhea treated by infantile massage combined w ith acupoint application
LIANG Rui-fen;　LIANG Feng-hao
ObjectiveTo explore and analyze the clinical nursing effect by infantile massage combined with acupoint application of traditional Chinese medicine in the treatment of infantile diarrhea.MethodsFrom January 2017 to January 2018,a total of 80 children with diarrhea diagnosed in pediatric outpatient department of our hospital were selected and divided into nursing group and control group according to the principle of random distribution,40 cases in each group.The control group was given Bacillus subtilis binomial living bacteria granules,Montmorillonite dispersion and routine nursing care.The nursing group was performed infantile massage combined with acupoint application on the basis of the control group.The clinical efficacy and satisfaction with nursing were compared in two groups.ResultsThe total effective rate of clinical efficacy of the nursing group(97.5%)was significantly higher than that of the control group(82.5%).The difference was statistically significant(P<0.05).The total satisfaction rate of the nursing group was significantly higher than that of the control group.The difference between the two groups was statistically significant(P<0.05).ConclusionOn the basis of routine treatment and nursing care,the combination of infantile massage and acupoint application can obviously improve the curative effect and the satisfaction of the children′s family to the nursing work.It is worth popularizing in clinic.
2018 Vol. 25 (17): 194-196 [Abstract] ( 140 ) HTML (33 KB)  PDF  (0 KB)  ( 33 )
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