右美托咪定联合地佐辛用于帝视内镜引导清醒插管的应用价值

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (0 KB) HTML (40 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo investigate the effects of Dexmedetomidine combined with Dezocine for application of awake intubation guided by disposcope endoscope.MethodsFrom August 2017 to January 2018,40 patients required intubation in our hospital were randomly divided into group A and B.Group A was treated intravenous injection of Midazolam and Sufentanil;group B was treated intravenous infusion of Dexmedetomidine,intravenous injection of Dezocine.The MAP and HR were recorded.,and the recording time was 4 times in operation room(T0),before intubation(T1),after tracheal intubation(T2)and 10 min after extubation(T3),using Ramsay Score,intubation tolerance score satisfaction score to evaluate intubation process and,the number of patients with respiratory depression was recorded.ResultsAll of the 40 patients were successfully intubated.The score of Ramsay in group B was superior to that of group A at T3(P<0.05).MAP and HR of both groups were decreased after treatment,with statistical difference at T1and T2,while group B(P<0.05).At T3,the HR of group B was lower than that of group A　(P<0.05),and the satisfaction of group B was better than that of group A　(P<0.05).And no patients with respiratory depression in group B.ConclusionWith the application of Dexmedetomidine combined with Dezocine,in the process of intubation and extubation in patients with more stable hemodynamics;patients with sedative effect and higher satisfaction;it is worthy of clinical application.

Key words： Dexmedetomidine Dezocine Midazolam Sufentanil Awake intubation Application value

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Wen-jia
	JIANG Lin
	SUN Can-lin

Cite this article:

CHEN Wen-jia,　JIANG Lin,　SUN Can-lin. Application of Dexmedetom idine combination w ith Dezocine in awake intubation guided by dioscorea[J]. 中国当代医药, 2018, 25(17): 131-133转136.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I17/131

[1]	Gao JM，Meng XW，Zhang J，et al.Dexmedetomidine protects Cardiomyocytes against Hypoxia/Reoxygenation injury by Suppressing TLR4-MyD88-NF-κB Signaling[J].Biomed Res Int，2017，2017（3）：1674613.
[2]	徐春城.右美托咪定联合帝视内镜在全身麻醉气管插管老年患者中的应用效果[J].中国当代医药，2016，23（34）:120-122.
[3]	O'Brien JJ，Benfield P.Dezocine.A preliminary review of its pharmacodynamic　and　pharmacokinetic　properties，and therapeutic efficacy[J].Drugs，1989，38（2）：226-248.
[4]	Strain EC，Preston KL，Liebson IA，et al.Opioid antagonist effects of dezocine in opioid-dependent humans[J].Clin Pharmacol Ther，1996，60（2）：206-217.
[5]	彭沛华，陈燕曾毅.右美托咪定和咪达唑仑用于清醒插管患者镇静的效果比较[J].实用医学杂志，2011，27（13）：2428-2429.
[6]	马建军.不同负荷剂量右旋美托咪定对成人行清醒气管插管的影响[J].中外医疗，2013，32（6）：115-116.
[7]	李寿春，翁浩，王学敏，等.帝视内镜用于模拟颈椎制动患者气管插管的效果[J].上海医学，2016，39（4）：214-217.
[8]	刘卓，赵莉，于洋，等.帝视内镜与纤维支气管镜在清醒气管插管时的比较[J].重庆医学，2016，45（26）：3709-3711.
[9]	许旭东，齐敦益，许晓勤，等.右美托咪定用于纤支镜引导清醒气管插管镇静[J].现代医学，2014，51（12）：1436-1438.
[10]	Ishizaki H，Terao Y，Taniguchi M，et al.Analysis of the factors in successful helmet non-invasive positive pressure ventilation[J].Masui，2015，64（10）：1023-1029.
[11]	Kohli U，Muszkat M，Sofowora GG，et al.Effects of variation in the human alpha2Aand alpha2C-adrenoceptor genes on cognitive tasks and pain perception[J].Eur J Pain，2010，14（2）：154-159.
[12]	Taittonen MT，Kirvela A，Aantaa R，et al.Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state[J].Br J Anaesth，1997，78（4）：400-406.
[13]	Zhang X，He W，Wu X，et al.TCI remifentanil vs.TCI propofol for awake fiber-optic intubation with limited topical anesthesia[J].Int J Clin Pharmacol Ther，2012，50（1）：10-16.
[14]	Liu R，Huang XP，Yeliseev A，et al.Novel molecular targets of dezocine and their clinical implications[J].Anesthesiology，2014，120（3）：714-723.
[15]	He L，Ding Y，Chen H，et al.Dezocine pretreatment prevents myoclonus induced by etomidate：a randomized，double-blinded controlled trial[J].J Anesth，2015，29（1）：143-145.
[16]	Li S，Zhan H.Dong，Research of dezocine in clinical ap-plication[J]Med Recapitulate，2012，18（23）：4021-4023.
[17]	Su XMeng ZT，Wu XH，et al.Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery： a randomised， double-blind，placebo-controlled trial[J].Lancet，2016，388（10054）：1893-1902.
[18]	Zhou M，Wang L，Wu C，et al.Reprint of：eFFICACY and safety of different doses of dezocine for preemptive analgesia in gynecological laparoscopic surgeries：a prospective，double blind and randomized controlled clinical trial[J].Int J Surg，2018，49：84-90.