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2017 Vol. 24, No. 29
Published: 2017-10-18
4
Prevention effect and mechanism of salvianolic acid A of water-soluble component from Salvia miltiorrhiza on hepatic fibrosis induced by carbon tetrachloride in rats
WU Xiong-jian；ZHENG Hong；ZHU Hai-yan；MAO Zhong-yi；XIE Jun
ObjectiveTo explore the preventive effect and mechanism of salvianolic acid A of water-soluble component from Salvia miltiorrhiza on hepatic fibrosis induced by carbon tetrachloride in rats.Methods48 adult male SD rats were selected and randomly divided into the sham group,the model group,the salvianolic acid A group,and the Wnt channel blocker group(DKK-1),with 12 rats in each group.Except the sham group,the CCl4was injected in other three groups to establish hepatic fibrosis model in rats.In the salvianolic acid A group,10 mg/(kg·d)salvianolic acid A was intraperitoneally injected after 8-week modeling.In the Wnt channel blocker group,the DKK-1 and 10 mg/kg salvianolic acid A were intraperitoneally injected after 8-week modeling.For the sham group and the model group,the same volume of saline was intraperitoneally injected after 8-week modeling.The rats were sacrificed 6 weeks after medications.Two liver tissues from the middle of the right lobe of the liver were collected for test.One of them was fixed with 10%formaldehyde and prepared into paraffin sections.The other one was stored in a refrigerator at-70℃for molecular biological detection.ResultsBy Western blot detection,the expression of α-SMA,TIMP-1 and Collagen Ⅰ proteins in the model group was significantly higher than that in the sham group,while in the salvianolic acid A group and Wnt channel blocker group,the proteins expression mentioned above could be obviously down-regulated after the corresponding therapy.In the model group,the expression levels of α-SMA,MMP-2,TIMP-1,Collagen Ⅰ and CollagenⅢmRNA were much higher compared with those in the sham group,while in the salvianolic acid A group and the Wnt channel blocker group,these indexes were greatly down-regualted after the related therapy.The Gsk3β and β-catenin expression levels in the model group were much higher than those in the sham group.The β-catenin expression level was extremely higher than that in the sham group.In the salvianolic acid A group and the Wnt channel blocker group,after the corresponding therap,the Gsk3β and βcatenin expression levels could be significantly down-regulated.ConclusionSalvianolic acid A may inhibit hepatic fibrosis by activating Wnt/β-catenin signal pathway.
2017 Vol. 24 (29): 4-06转10 [
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219
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The experimental research on the influence of Silybin on cavies′s skin pigmentation
XU Yan-ming；YANG Liu；FU Wei；LI Jian-min ；WANG Xue
ObjectiveTo explore the influence of Silybin on guinea pigs model induced pigmentation by UVB.MethodsBrown yellow guinea pigs were irradiated by ultraviolet ray phototherapy apparatus,the skin pigmentation of guinea pigs model was established,the guinea pigs were divided into blank control group,model group,matrix group,treatment group,and positive control group,there were 40 guinea pigs,each group 8 guinea pigs.Model group,treatment group and positive control group were irradiated by 1 min for 20 days continually,matrix group,treatment group and positive control group were used matrix,silybin and Olay for 30 days,the SOD,CAT,TYR and TRP－2 content in guinea pigs were tested.ResultsCompared with model group,guinea pigs′skin pigment becomes shadow distinctively,SOD,CAT activity in tissue homogenizing fluid becomes high distinctively,the differences were statistically significant （P＜0.05）,TYR,TRP－2 contents decrease distinctively （P＜0.05）.ConclusionSlybin can inhibit skin pigmentation,the mechanism function may be related to the ability of removal free radicals from oxidative damage and inhabitation of tyrosine′s activity
2017 Vol. 24 (29): 7-10 [
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Clinical effect of Bromocriptine treating pituitary prolactinoma
ZHANG Fang-fang；ZHANG Jiang-nan；LIN Lan-mei；HUANG Yin-xing
ObjectiveTo analyze the usage and effect of Bromocriptine treating pituitary prolactinoma.Methods47 patients with pituitary prolactinoma treated from June 2014 to June 2016 were selected as the subjects.Among them,there were 27 patients with pituitary microadenoma(tumor diameter≤10 mm),20 patients with pituitary macroadenoma(tumor diameter＞10 mm);there were 5 cases with 25 μg/L≤PRL＜100 μg/L,22 cases with 100 μg/L≤PRL＜200 μg/L,20 cases with PRL≥200 μg/L.After the patients were diagnosed,they are treated with Bromocriptine immediately.Serum prolactin level was regularly reviewed and pituitary enhanced MRI scan was conducted.PRL level and tumor size change were analyzed before and after treatment and the adverse reactions during the period of medication were monitored,and the treatment plan was adjusted in time.ResultsAfter Bromocriptine treatment,3 patients had severe adverse reactions and were replaced with Cabergoline.Among 44 patients who continued to take Bromocriptine medication,the symptom improvement rate was 70.5%.There was no significant difference in the therapeutic effect between different tumor size and different PRL level(P＞0.05).The changes of tumor diameter before and after treatment were statistically significant(P＜0.05).36.2%(17 patients)of patients in the medication had varying degrees of adverse reactions,the majority could be gradually tolerated.ConclusionBromocriptine has a significant therapeutic effect on hyperprolactinemia and tumor size in patients with pituitary prolactinoma,but there are several adverse reactions during treatment,and the therapeutic dose should be individualized.Patients with ineffective treatment should be preferred to replace the other dopamine receptor agonists.
2017 Vol. 24 (29): 11-14 [
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The progress of the NF-κB signaling pathway regulated by miRNA-16
LIU Chao ；CHEN Han-juan
The miRNA-16,gene of coding which is located on chromosome 13,belong to the non-coding RNA and consists of 22 nucleotides,which could regulate the expression of NF-κB.NF-κB is a multidirectional adjustment of transcription factors,such as NF-κB couldn adjust the protein Bcl-x expression and other anti-apoptotic proteins exprsssion when also could adjust the protein IL-2 expression and other growth factors expression,also could adjust the gene-TRAF1 expression and other anti-apoptotic gene expression.Therefore,NF-κB is closely related to tumor proliferation and apoptosis.MiRNA-16 may be combined with promoter region or 3′UTR of the NF-κB,and could indirectly regulate anti-apoptotic genes,anti-apoptotic proteins and growth factors by NF-κB.The synthesis and function of mirna-16 and NF-κB were reviewed in this paper,and the potential anti-apoptotic gene,anti-apoptotic protein,growth factor and other control targets of mirna-16 were reviewed.
2017 Vol. 24 (29): 15-17 [
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18
Analysis effect of aerosol inhalation of Budesonide and Ipratropium bromide in the treatment of senile chronic obstructive pulmonary disease
SONG Lin-yuan
ObjectiveTo explore the clinical therapeutic effect of aerosol inhalation of Budesonide and Ipratropium bromide in the treatment of senile chronic obstructive pulmonary disease.MethodsFrom January 2015 to June 2016,60 patients with moderate to severe chronic obstructive pulmonary disease were selected as research object.They were randomly divided into study group and control group by random number table,30 cases in each group.The study group were given inhaled Budesonide and Ipratropium bromide treatment,the control group were given inhaled with stioke physiscogical saline solation.Peak airway pressure of 10 min before and after treatment with 5 min,SpO2,arterial blood gas pH value,partial pressure of oxygen,partial pressure of carbon dioxide of before anesthesia without oxygen state and after anesthesia recovery without oxygen inhalation after 10 min were observed and compared between the two groups.ResultsBefore the treatment of 5 min two groups of patients with peak pressure,the difference had no statistical significance(P＞0.05),after the treatment of airway 10 min study group of patients with peak pressure was significantly lower than the control group.The SpO2,PaO2of the study group of patients were significantly higher than the control group,the partial pressure of carbon dioxide was significantly lower than the control group;the success rate of postoperative 1 h in the study group was 90.00%,which was significantly higher than that of the control group of 56.67%;the differences were statistically significant(P＜0.05).ConclusionThe clinical treatment effect of the inhalation of Budesonide and Ipratropium bromide in the treatment of senile chronic obstructive pulmonary disease is remarkable.It is an ideal choice for clinical practice.
2017 Vol. 24 (29): 18-20 [
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159
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Effect of pulmonary recruitment in prone position on oxygenation index，intrapulmonary shunt and hemodynamics in patients with severe pulmonary infection and hypoxemia
ZOU Xin-hui；LUO Wei-wen；ZHONG Ying-yu
ObjectiveTo explore the effect of prone position of lung recruitment on oxygenation index in patients with hypoxemia in patients with severe pulmonary infection,intrapulmonary shunt,hemodynamics.Methods88 cases of hypoxemia in patients with severe pulmonary infection from March 2015 to March 2017 in our hospital,according to patients with atelectasis were divided into prone group(n=44,pulmonary recruitment in prone position)and supine group(n=44,supine lung recruitment),the status of the therapeutic effects and safety of statistics of the two groups were compared.ResultsThe prone group after treatment in patients with SpO2,PaO2/FiO2,CI,SVI,CVP,GEF respectively (102.9±2.7)%and (398.2±43.8),(3.6±0.4)L/min,(32.7±3.4),(3.9±1.1)cmH2O,(26.8±2.5)%,significantly higher than the supine group[(95.2±2.6)%and (328.3±42.7),(3.3±0.5)L/min,(30.5±3.5),(3.2±0.7)cmH2O,(24.1±2.7)],the difference was statistically significant(P＜0.05);the prone group after treatment in patients with Qs/Qt and SVRI respectively (9.5±0.8)%and(10.8±1.3)%,significantly lower than the supine group [(11.2±1.3)%and (12.2±1.5)%],the difference was statistically significant(P＜0.05).The incidence of side effects in the prone group after treatment was 6.8%,compared with that in the supine group(9.1%),and there was no significant difference(P＞0.05).ConclusionSevere pulmonary infection prone atelectasis patients can improve the oxygenation index,the implementation of hypoxemia in patients with intrapulmonary shunt and reduce the effects on hemodynamics.
2017 Vol. 24 (29): 21-23 [
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166
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24
Comparison of the effect of elastic wire ligature stapler and apron stapler in the treatment of mixed hemorrhoids
LIANG Jia-ji；LIAO Ming ；CHEN Xing-yi；XIAO Liu
ObjectiveTo investigate the effect of elastic wire ligation stapler(RPH－4)and loop stapler(RPH)in the treatment of hemorrhoids.Methods290 cases of patients with mixed hemorrhoids from March 2014 to June 2016 in our hospital as the research object,according to different surgical methods,divided into control group and intervention group,with 145 cases in each group.The control group was treated with RPH treatment,the intervention group used RPH－4therapy stapler.The operation time and length of stay in two groups were recorded,and the curative effect and postoperative complications were observed and analyzed.ResultsThere was no significant difference in the operation time between the two groups,and there was no statistical significance(P＞0.05).The postoperative hospital stay in the intervention group was significantly less than that in the control group,the difference was statistically significant(P＜0.05).The total effective rate of the control group was lower than that of the intervention group,the difference was statistically significant(P＜0.05).The number of postoperative pain and postoperative anal distension sensation in the intervention group was significantly less than that of the control group,the difference was statistically significant(P＜0.05).The patients in the intervention group did not suffer from massive hemorrhage，which was significantly less than that of the control group，with statistical significance(P＜0.05).There were no complications such as anal incontinence,stenosis and perianal infection in the two groups.ConclusionRPH－4 and RPH can effectively treat hemorrhoid patients,but compared with traditional ligation therapy,RPH－4 has the advantages of simple operation,short treatment time,accurate curative effect and minimal invasion.It can obviously reduce the postoperative pain,postoperative anal distention,and the incidence of postoperative complications such as massive bleeding.
2017 Vol. 24 (29): 24-26转35 [
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Analysis of application effect of modified early warning score in emergency internal medicine
XIA Lian-xiang； XIE Ai-rong ；LI Xiao-hong
ObjectiveTo discuss the application effect of modified early warning score in emergency internal medicine.Methods200 cases in internal medicine emergency in our hospital from June 2015 to July 2017 were selected as study objects.All cases were evaluated by MEWS.The where abouts and prognosis of patients with different scores in different score group was compared.Results128 cases scored≤4 points,and 72 cases scored≥5 points and were sent to ICU rates,and mortality of cases with MEWS≥5 points were higher than those of those of cases with MEWS≤4 points,which showed significant difference(P＜0.05).ICU rates in cases with MEWS 7－8 points,≥9 points were higher than those of cases with MEWS 5－6 points，3－4 points and 0－2 points，and cases with MEWS 5－6 points was higher than that of cases with MEWS 3－4 points and 0－2 points,which showed significant difference(P＜0.05）.Mortality of cases with MEWS 7－8 points and ≥9 points were higher than that of the cases with 0－2,3－4 points and 5－6 points,which showed significant difference(P＜0.05).ConclusionThe application of MEWS in emergency department has important clinical significance for evaluating the patients′condition,and can effectively predict the prognosis of the patient.
2017 Vol. 24 (29): 27-29 [
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170
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Clinical application of painless gastrointestinal endoscopy and conventional gastrointestinal endoscopy in digestive tract diseases
MA Gui-yang
ObjectiveTo compare the effect of painless gastrointestinal endoscopy and conventional gastrointestinal endoscopy in digestive tract diseases.Methods396 digestive tract diseases patients from September 2015 to June 2017 in our hospital were selected.Patients were divided into two groups according to different check mode,and each group was 198 cases.Patients in observation group were used painless gastrointestinal endoscopy and the control group were used conventional gastrointestinal endoscopy.The changes of heart rate，blood pressure and blood oxygen saturation(SpO2)in the two groups before,during and after the examination were recorded and compared.The adverse reactions in the course of the examination were compared,and the results of the two groups were compared.ResultsThe heart rate，blood pressure and SpO2of the observation group did not change significantly at each time point(P＞0.05);The heart rate and blood pressure during operation and after operation were significantly better than those in the control group(P＜0.01);The intraoperative rate and blood pressure in the control group were significantly higher than those before operation and after operation(P＜0.01),but there was no significant change in SpO2(P＞0.05).The incidence rate of adverse effect in observation group was 10.10%,significant lower than that was 57.58%in control group(P＜0.01).In the examination，the excellent and good rate of the observation group was 93.93%,which was significantly better than that of the control group(77.28%)(P ＜0.01).ConclusionCompared with routine gastrointestinal endoscopy，painless gastrointestinal endoscopy has less pain，lower rate of adverse reactions，higher compliance，and is worthy of further clinical promotion.
2017 Vol. 24 (29): 30-32 [
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168
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Comparison and analysis the effect of laparoscopic cholecystectomy and open cholecystectomy
ZHANG Yi-dan
ObjectiveTo investigate the treating effect of laparoscopic cholecystectomy and open cholecystectomy.Methods106 patients with gallbladder disease treated in Central Hospital of Pulandian District from March 2015 to May 2016 were selected.Patients were grouped by computer random grouping method,and each group was 53 cases.The routine group was given open cholecystectomy,and the experimental group was given laparoscopic cholecystectomy.The effect between the two groups was compared.ResultsThe bleeding amount during operation in the experimental group were significantly fewer than those of the routine group,operation time,hospitalization time,gastrointestinal function recovery time were significantly shorter than those of the routine group(P＜0.01).The incidence of postoperative intestinal adhesion in the experimental group was 3.77%,which was significantly lower than that of the routine group(24.53%)(P=0.0020).The incidence of total complication in the experimental group was 9.43%,which was significantly lower than that of the routine group(30.19%)(P＜0.05).ConclusionThe effect of laparoscopic cholecystectomy in the treatment of gallbladder diseases is remarkable,and its safety is more higher,and the hospitalization time and operation time were shorter,and the complications are fewer.It is worthy of practice and popularization.
2017 Vol. 24 (29): 33-35 [
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Correlation between ventilation function and blood lipid metabolism,insulin resistance,atherosclerosis degree in patients with cerebral infarction complicated with sleep apnea
LU Feng-cai
ObjectiveTo investigate the correlation etween ventilation function and blood lipid metabolism,insulin resistance,atherosclerosis degree in patients with cerebral infarction complicated with sleep apnea.Methods32 patients with cerebral infarction complicated with sleep apnea treated in our hospital from September 2014 to December 2016 were collected as group A,43 patients with simple cerebral infarction were selected as group B,and 50 healthy subjects who
received：
physical examination in our hospital during the same period were collected as normal control group.Ventilation function index,blood lipid metabolism index and insulin resistance index and ultrasonic atherosclerosis parameter of three groups were determined.Pearson method was used to assess the correlation between ventilation function and blood lipid metabolism,insulin resistance and atherosclerosis parameter in patients with cerebral infarction complicated by sleep apnea.ResultsVentilation function indexes FEV1and FEV1/FVC level of group A and group B were lower than those of normal control group(P＜0.05),blood lipid metabolism indexes such as TC,TG and LDL－C content in peripheral blood were higher than those of normal control group (P＜0.05),while HDL－C content were lower than those of normal control group(P＜0.05).FINS and HOMA－IR level in peripheral blood were higher than those of normal control group(P＜0.05).Ultrasonic atherosclerosis parameter such as IMT,AC and PWVβ level were higher than those in normal control group,and the above changes in group A were greater than those in group B (P＜0.05).Pearson test showed that the ventilation function level in patients with cerebral infarction complicated by sleep apnea were directly correlated with the blood lipid metabolism,insulin resistance and atherosclerosis severity.ConclusionThere are ventilation function inhibition in patients with cerebral infarction complicated by sleep apnea,and the specific state of ventilation is directly correlated with disease severity indicators such as blood lipid metabolism,insulin resistance,atherosclerosis and so on.
2017 Vol. 24 (29): 36-39 [
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Effect exploration of laparoscopic surgery applied for patients in department of hepatobiliary surgery
LIU Yi-ping；HUANG Yu-hai；ZHANG Ling
ObjectiveTo explore the effect of laparoscopic surgery applied for patients in department of hepatobiliary surgery.MethodsFrom July 2015 to July 2017,78 patients in department of hepatobiliary surgery treated in our hospital were selected and they were divided into the two groups according to the random number table method,and there were 39 cases in each group.The control group was treated with conventional laparotomy,and the study group was treated with laparoscopic surgery.The therapeutic effect between the two groups was compared.ResultsThe total effective rate and satisfaction rate of the study group were significantly higher than those of the control group,and the use rate of analgesic drugs was lower than that of the control group,and the difference was statistically significant(P＜0.01).The incision length of the study group was significantly less than the control group,the bleeding amount during operation was significantly less than the control group,operation time,ambulation time and average hospitalization time were shorter than those of the control group,and the difference was statistically significant(P＜0.01).The complications of varying degrees of abdominal distention,wound bleeding,wound infection and biliary fistula occurred in the two groups,and the incidence of postoperative total complications in the study group was 7.69%,which was significantly lower than that of the control group (25.64%),and the difference was statistically significant(P＜0.05).ConclusionLaparoscopic surgery applied for patients in department of hepatobiliary surgery can significantly improve the clinical efficacy,reduce the use rate of analgesic drugs,optimize the operation indexes,and reduce the incidence of postoperative complications,and is worthy of clinical wide application.
2017 Vol. 24 (29): 40-42 [
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Risk factors analysis of rebleeding of non-variceal upper gastrointestinal hemorrhage treated by gastrointestinal endoscopy
WU Lian-hui；LUO Jia；LIN Ming-fang
ObjectiveTo analyze the risk factors of rebleeding of non－variceal upper gastrointestinal hemorrhage treated by gastrointestinal endoscopy.MethodsFrom February 2015 to February 2017,a total of 216 patients with non－variceal upper gastrointestinal bleeding who underwent endoscopic treatment in our hospital were selected as research objects.A-mong them,41 patients occurred with rebleeding and classified into the observation group,and the rest(n=175)without rebleeding was categorized into the control group.The basic data,examination indexes,and treatment process were recorded and compared.ResultsIn the observation group,the levels of hemoglobin and thrombocyte were both remarkably lower than those in the control group(P＜0.05).The percentage of vascular malformation,treatment time＞24 h,cardia tearing,hemorrhage of gradeⅠa,insufficiency of supportive treatment,hemorrhage due to malignant tumors and lack of following PPIs were all much higher than those in the control group (P＜0.05).Vascular malformation,Hemorrhage of gradeⅠa,cardia tearing and hemorrhage due to malignant tumors were all independent risk factors leading to rebleeding after gastrointestinal endoscopy(P＜0.01).ConclusionFor patients suffering from non－variceal upper gastrointestinal hemorrhage after gastrointestinal endoscopy,insufficiency of supportive treatment and low－level of hemochrome causes rebleeding.Besides,hemorrhage due to malignant tumor is also an important risk factor,which should be strengthened protection in time in order to ensure health of patients.
2017 Vol. 24 (29): 43-45 [
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Clinical effect of low-dose Etoposide in the maintenance treatment of small cell lung cancer
WANG Fan ；WAN Bao-lin； YI Jun
ObjectiveTo explore the clinical effect of low dose Etoposide in the maintenance treatment of small cell lung cancer.MethodsThe clinical data of 80 patients with limited-stage small cell lung cancer admitted into our hospital from January 2014 to January 2015 were retrospectively analyzed.According to the different therapeutic methods,all patients were divided into the research group and the control group,40 cases in each group.In the research group,lowdose Etoposide Capsule as a maintenance therapy was adopted,while in the control group,no medication was given.After 24-month follow-up visits,the therapeutic effect in the two groups was compared.ResultsThe disease free survival time in the research group was greatly longer than that in the control group,with significant difference (P＜0.05).In the research group,the survival rates in 12thand 24thmonths after follow-up visits were both higher than those in the control group,with significant differences(P＜0.05).After 12,18,and 24-month follow-up visits,the scores of quality of life in the research group were all superior to those in the control group,with significant differences(P＜0.05).ConclusionIn the process of treating small cell lung cancer,application of low-dose Etoposide as a maintenance therapy can obtain a optimal effect by prolonging the disease free survival time,increasing the survival rate within 24 months,and improving long-term quality of life,which is worthy of further study and promotion.
2017 Vol. 24 (29): 46-48 [
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Relationship between GLI1 and epithelial-mesenchymal transition in gastric cancer and its clinical study
LIN Zhi-ping；DUAN Zhao
ObjectiveTo observe the relationship between GLI1 expression and epithelial-mesenchymal transition in gastric cancer.Methods58 cases of gastric cancer specimens who were given surgical resection with clear diagnosis and complete data from January 2006 to December 2011 were collected,and tissue microarray was made.The expression of GLI1,E-cadherin and N-cadherin in gastric carcinoma and normal gastric mucosa in tissue microarray were detected by immunohistochemical SP method.ResultsGLI1 expression in gastric cancer was higher than that in normal tissues(P＜0.05),which was significantly associated with lymph node metastasis,clinical staging,Lauren typing and tumor differentiation of gastric cancer,with significant difference(P＜0.05).The expression of E-cadherin in normal gastric mucosa was higher than that in gastric cancer(P＜0.05),which was significantly associated with lymph node metastasis,clinical staging,Lauren typing and tumor differentiation of gastric cancer,with significant difference(P＜0.05).The expression of N-cadherin in gastric cancer was higher than that in normal gastric mucosa(P＜0.05),which was significantly associated with lymph node metastasis,clinical staging,Lauren typing and tumor differentiation of gastric cancer,with significant difference(P＜0.05).GLI1 expression was associated with epithelial-mesenchymal transition,with significant difference(P＜0.01).ConclusionThe expression of GLI1 in gastric cancer is associated with E-cadherin and N-cadherin,indicating that GLI1 may be involved in the EMT process.
2017 Vol. 24 (29): 49-52 [
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Clinical effect of Pemetrexed combined with Tegafur Gimeracil Otera in the treatment of recurrent metastatic breast cancer
WANG Min ；ZHAO Jian-hua
ObjectiveTo observe and analyze the clinical efficacy and adverse reactions of Pemetrexed combined with Tegafur Gimeracil Otera in the treatment of recurrent metastatic breast cancer.MethodsFrom August 2015 to August 2016,56 patients with recurrent metastatic breast cancer in our hospital were selected and randomly divided into the control group and the observation group,28 cases in each group.In the observation group,Pemetrexed combined with Tegafur Gimeracil Otera was adopted,every 3 weeks was considered as a treatment cycle.In the control group,only Tegafur Gimeracil Otera was used,every participant should be treated for at least two cycles,and effect and adverse reactions were evaluated between the two groups.ResultsIn the observation group,the survival rate and recurrence rate were 75.00%and 3.57%respectively,which were both superior to those in the control group(35.71%,39.29%),with significant difference(P＜0.05).There was no significant difference between the two groups in mortality(P＞0.05).The incidence of digestive tract reaction in the observation group was 32.14%,the incidence rate of hematologic toxicity was 46.43%,and the incidence of liver function toxicity was 32.14%,which were lower than those in the control group(57.14%,72.43%,25.00%),with significant difference (P＜0.05).There was no significant difference in the incidence of neurotoxicity and liver function toxic reaction between the two groups(P＞0.05).ConclusionCombination of Pemetrexed and Tegafur Gimeracil Otera can obtain a remarkable effect on treating recurrent metastatic breast cancer in a low adverse reactions.It can be tolerated and is worthy of clinical promotion and research.
2017 Vol. 24 (29): 53-55 [
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Clinical effect of percutaneous biliary metal stenting on hilar cholangiocarcinoma
SHEN Bo；LUO Jun-feng；PAN Jing-gang；ZHANG Yu-ting
ObjectiveTo investigate the clinical effect of percutaneous biliary metal stenting in patients with hilar cholangiocarcinoma.MethodsA total of 62 patients with hilar cholangiocarcinoma who had lost the opportunity of surgical resection from January 2011 to December 2014 were selected.Percutaneous biliary metal stenting was carried out under the guidance of ultrasonography.After 1 week,the biliary metal stent implantation was performed under DSA fluoroscopy.The external drainage in the percutaneous biliary metal stenting was switched into the internal drainage within biliary stent.ResultsA total of 56 patients with hilar cholangiocarcinoma out of 62 patients were successfully implanted with biliary stent.The success rate was 90.3% .The serum total bilirubin in 56 patients with hilar cholangiocarcinoma was decreased from (290.3±170.0)μmol/L before the surgery to (108.2±62.0)μmol/L.The serum direct bilirubin was decreased from(197.3±119.2)μmol/L before the surgery to(49.2±19.4)μmol/L.Alanine aminotransferase was decreased from (206.3±127.4)U/L to (80.1±55.8)U/L after the surgery.Aspartate aminotransferase was decreased from (180.1±95.2)U/L to (94.2±59.7)U/L after the surgery.γ－glutamyl transpeptidase was decreased from (756.8±302.1)U/L to(230.1± 101.5)U/L.AFP was decreased from(120.3±32.2)μg/L to(98.2±10.8)μg/L.All the differences were statistically significant(P＜0.05).ConclusionPercutaneous biliary metal stenting can effectively improve the liver function of patients with hilar cholangiocarcinoma， which is worthy of clinical promotion and application.
2017 Vol. 24 (29): 56-58 [
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Efficacy of Tegafur combined with Oxaliplatin in the treatment of elderly advanced gastric carcinoma
LIU Jian-jun ；CUI Lin； ZHOU Xiang-rong； DING Jie
ObjectiveTo investigate the clinical application effect of Tegafur combined with Oxaliplatin in the treatment of elderly advanced gastric carcinoma.Methods60 elderly patients with advanced gastric carcinoma who were admitted to our hospital from January 2013 to February 2017 were selected as the subjects of this study.According to the odd and even number methods(order of admission),the enrolled elderly patients with advanced gastric cancer(n=60)were randomly assigned to the study group(n=30)and the control group(n=30).In the study group,the elderly patients with advanced gastric cancer were treated with Tegafur combined with Oxaliplatin,and the control group was treated with Capecitabine combined with Oxaliplatin.The short－term efficacy and incidence of adverse events were recorded in the two groups of elderly patients with advanced gastric cancer.ResultsThe total effective rate(56.67%)in the study group was higher than that in the control group(40.00%),and the difference was statistically significant(P＜0.05);the incidence rate of diarrhea and hand foot syndrome(HFS)in the study group was significantly lower than that in the control group during chemotherapy,and the difference was statistically significant(P＜0.05).There were no statistically significant differences in nausea,vomiting,myelosuppression and other adverse reactions between the two groups(P＞0.05).ConclusionThe combination of Oxaliplatin and Tegafur in the treatment of elderly advanced gastric cancer can improve the curative effect of these patients,and at the same time can reduce the incidence rate of adverse reactions during chemotherapy,which is conducive to ensuring the quality of life and life safety.
2017 Vol. 24 (29): 59-61 [
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Influence of nutritional management combined with moxibustion on quality of life in patients with lung cancer after radical operation
WANG Li-Qin ；ZHANG Juan
ObjectiveTo analyze the effect of nutritional management combined with moxibustion on quality of life in patients with lung cancer after radical operation.MethodsOur research team build the nutritional management group,performed the efficiency mode of nutritional management.From December 2013 to December 2016,96 cases patients with lung cancer after radical operation were divided randomly into nutritional support therapy group(n=48)and control group(n=48).All patients followed prescribed therapy,the treatment group were given nutritional support combined with moxibustion.The quality of life,hospital stay and satisfaction rate were compared between two groups.ResultsThe satisfaction rate was 93.8%in treatment group and 79.2%in the control group,there was significant difference between them(P＜0.05).The hospital stay in treatment group was lower than the control group(P＜0.05).The body function,mood function,fatigue,vomiting eased,cough,breathing problem and chest pain in treatment group were better than control group,there was significant difference between them(P＜0.05).ConclusionThe nutritional management combined with moxibustion could improved the quality of life,shorten the length of hospital stay,improved the satisfaction rate in patients with lung cancer after radical operation.
2017 Vol. 24 (29): 62-64转74 [
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The role of TWEAK and Fn14 in the pathogenesis of endometriosis
SHU Ru-ming ；HE Jie
ObjectiveTo investigate the expression and function of tumor necrosis factor like apoptosis inducer(TWEAK)and fibroblast growth factor inducible 14(Fn14)in endometriosis(EMs).Methods50 EMs patients in department of obstetrics and gynecology of our hospital from June 2014 to June 2015 were selected as the subjects.Among them,30 cases were ectopic cyst wall group,20 cases were eutopic endometrium group.At the same time,20 patients who
received：
hysterectomy in the study group matched with the diseases of uterine fibroids and cervical lesions were collected as the control group.Gene and protein expression in different groups by immunohistochemistry,Western－Blot and RT－PCR detection of TWEAK,Fn14,according to the data analysis of TWEAK,Fn14 expression level and CA－125 level,anti endometrial antibody(EMAb),modified endometriosis stage(r－AFS)correlation analysis.ResultsThe positive rates of TWEAK and Fn14 were significantly different between the three groups,the differences were statistically significant(P＜0.05).The positive rates of TWEAK and Fn14 in ectopic cyst wall group and eutopic endometrium group were significantly higher than those in the control group,the differences were statistically significant(P ＜0.05).The positive rates of TWEAK and Fn14 in patients with EMs were significantly different in r－AFS,CA－125 and EMAb,and the differences were statistically significant(P＜0.05).According to the correlation analysis,the expression levels of TWEAK and Fn14 were positively correlated with r－AFS,CA－125 and EMAb(P＜0.05).ConclusionTWEAK/Fn14 is involved in the occurrence and development of endometriosis.Abnormal levels of TWEAK/Fn14 can lead to decreased apoptosis of endometrial cells.
2017 Vol. 24 (29): 65-67转87 [
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The clinical effect of Sodium Hyaluronate injection combined with Estrogen and Progesterone in the prevention and treatment of intrauterine adhesions after curettage
ZHANG Jin-xian； LIN Hui-ping ；LIU Hua-liu； CHEN Yue-qiong
ObjectiveTo investigate the clinical effect of sodium hyaluronate injection combined with estrogen and progesterone in the prevention and treatment of intrauterine adhesions after curettage.MethodsFrom January 2016 to March 2017,200 cases of artificial abortion and missed abortion in our hospital who had at least 2 times in the history of artificial abortion were selected as the research objects,they were divided into the control group and the observation group by taking computer random number method,100 cases in each group.The control group had not taken special treatment after the operation,the observation group had taken intrauterine injection of Sodium Hyaluronate combined with oral Estrogen and Progesterone after the operation.The amount of bleeding of intrauterine adhesions,the incidence of postoperative bleeding duration,duration of abdominal pain,menses time,reduce menstruation rate and amenorrhea rate were compared between two groups.ResultsThe adhesion of uterine cavity in the observation group were significantly lower than the control group,the difference was statistically significant(P＜0.05);the amount of bleeding in the observation group was less than that in the control group,the duration of bleeding,the duration of abdominal pain,the time of menstruation and tidal repetition were shorter than those in the control group,the differences were statistically significant(P＜0.05);3 months after surgery,the observation group of reduced rate of menstruation,the rate of closed were lower than the control group,the differences were statistically significant(P＜0.05).ConclusionThe combined Estrogen and Progesterone treated by sequential injection of Sodium Hyaluronate in uterine cavity repeatedly in patients with artificial abortion and missed abortion after curettage can effectively prevent postoperative intrauterine adhesions,but also can effectively relieve postoperative bleeding,abdominal pain and other symptoms,promote the recovery of patients after menstruation.
2017 Vol. 24 (29): 68-70 [
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Influence of estrogen-replacement therapy on insulin-like growth factor-1 and bone mineral density in patients with menopausal syndrome
MA Juan-wen ；CHEN Wei-wei；WANG Hui-qin； ZHAO Hui-feng；LI Hui
ObjectiveTo investigate the changes of serum insulin－like growth factor－1(IGF－1)and bone mineral density (BMD)before and after estrogen－replacement therapy in patients with climacteric syndrome.MethodsFrom June 2014 to June 2016,100 patients with menopausal syndrome admitted in our hospital were selected as objects and were randomly divided into research group and control group according to the order of visiting doctors,50 cases in each group.In the control group,routine treatment was used,while in the research group,on the basis of routine treatment,oraladministration of Estrdiolvlerte Tablet/Estradiol Progesterone Tablet for 6 continuous months.The Kupperman score,total effective rate,serum estradiol,insulin－like growth factor－1 (IGF－1)level,speed of ultrasound in tibia and radius were compared in research group and control group.ResultsAfter treatment,the improved Kupperman score of the research group was lower than the control group,and the difference was statistically significant(P＜0.05).The total apparent efficiency(94.0%)was higher than the control group(78.0%),and the difference was statistically significant(P＜0.05).After treatment,the serum E2and IGF－1 levels of the patients in the research group were higher than the control group,and the difference was statistically significant(P＜0.05).After treatment,the spread of tibial and radial ultrasound in the research group were higher than before treatment,and the differences were statistically significant(P＜0.05).ConclusionE-strogen－replacement therapy can increase the estrogen level,thereby alleviate the clinical symptoms of patients with menopausal syndrome,but also increase the level of serum IGF－1 and improve patient′s osteoporosis.
2017 Vol. 24 (29): 71-74 [
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Clinical effect of Live Combined Bifidobacterium and Lactobacillus Tablets combined with Compound Lysine Hydrochloride and Zinc Gluconate Granules in the treatment of children with acute diarrhea and its influence on recurrence rate
GUAN Ling-hong
ObjectiveTo investigate the clinical effects of Live Combined Bifidobacterium and Lactobacillus Tablets combined with Compound Lysine Hydrochloride and Zinc Gluconate Granules in the treatment of children with acute diarrhea and its influence on recurrence rate.Methods86 cases of children with acute diarrhea who accepted treatments in our hospital from September 2015 to January 2017 were selected as the research objects,and were divided into two groups by the random number table method,43 cases in each group.The control group were
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routine treatment (watersupplement,correction ofwater,electrolyte and acidosis,and were given the live Combined Bifidobacterium and Lactobacillus Tablets,etc.),while the observation group were treated with Compound Lysine Hydrochloride and Zinc Gluconate Granules on the basis of the control group.The clinical effects,gastrointestinal barrier function and recurrence rate after the treatment of two groups of patients were observed.ResultsThe total effective rate after the treatment tin the observation group (97.67%)was higher than that in the control group (81.40%),and the difference was statistically significant(P＜0.05).Before the treatment,there was no significant difference in the diamine oxidas(DAO)and D－lactic acid and endotoxin levels between the two groups(P＞0.05).After the treatment,the levels of DAO and D－lactic acid and endotoxin in the observation group were significantly lower than those in the control group,the difference was statistically significant(P＜0.05).There was no recurrence in the observation group after the treatment for 1 months,recurrence rate after the treatment for 2 months was 4.65%,and 3 months was 13.95%,while the control group respectively were 9.30%,20.93%,32.56%,the differences were statistically significant(P＜0.05).ConclusionThe effect of Live Combined Bifidobacterium and Lactobacillus Tablets combined with Compound Lysine Hydrochloride and Zinc Gluconate Granules in the treatment of children with acute diarrhea are significant,which can effectively improve the intestinal barrier function and reduce the recurrence rate,thus it is worthy to be promoted in the clinical.
2017 Vol. 24 (29): 75-77 [
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Comparative study of laparoscopic total hysterectomy and laparotomy in patients with uterine fibroids
CHEN Wei-zhong ；ZHANG Fei-fei；HE Ling-yan
ObjectiveTo investigate the clinical difference of laparoscopic hysterectomy and laparotomy in patients with uterine fibroids.MethodsFrom May 2015 to April 2017,82 patients with hysteromyoma who treated in our hospital were selected as objects.They were divided into observation group(n=41)and control group(n=41)according to random number table method.The control group was treated with open hysterectomy,and the observation group was treated with laparoscopic total hysterectomy.The operation time,bleeding volume,postoperative exhaust time,hospitalization time,FSH level and complication rate were compared between the two groups.ResultsOperation time was compared between the two groups,the difference was not statistically significant(P＞0.05),the patients in the observation group had less blood loss than the control group,the postoperative ventilation time and the hospitalization time were shorter than the control group,the differences were statistically significant(P＜0.05).Before treatment,the level of FSH was compared between the two groups,the difference was not statistically significant(P＞0.05).After treatment,the level of FSH of the patients in the observation group were compared with before treatment,the difference was statistically significant(P＜0.05).In the complication rate,the control group was much higher than the observation group,the difference was statistically significant(P＜0.05).ConclusionLaparoscopic hysterectomy compared with open surgery,it has many advantages in clinical application,to ensure the normal operation time,shorten surgery time and hospitalization time,reduce the amount of hemorrhage,improve the level of FSH,reduce the incidence of complications,can be popularized in clinical treatment.
2017 Vol. 24 (29): 78-80 [
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Comparative study on the effect of hysteroscopic uterine mediastinal cold knife operation and transurethral resection on endometrium
AI Dan；ZHONG Li-zhen
ObjectiveTo investigate the effect of hysteroscopic uterine mediastinal cold knife operation and transurethral resection of endometrium.MethodsFrom March 2016 to February 2017,62 patients with uterine mediastinal were selected as the subjects.The patients were randomly divided into two groups.Hysteroscopic resection was performed in the control group.The observation group was treated with hysteroscopic uterine mediastinal cold knife operation.The surgical conditions,endometrial healing,residual,uterine adhesions of two groups were compared.ResultsThe operation time[(15.11±2.82)min]and hospitalization time[(4.03±0.67)d]of the observation group were shorter than those in the control group[(28.04±1.96)min,(8.81±1.92)d],the differences were statistically significant(P＜0.05).Blood loss was compared between the two groups,the difference was not statistically significant(P＞0.05).The satisfaction rate of endometrial healing was 93.55%in the observation group,which was higher than that in the control group,the difference was statistically significant(P＜0.05).Residual and intracavitary adhesions were compared between the two groups,the differences were not statistically significant(P＞0.05).ConclusionCompared with hysteroscopic resection,hysteroscopic uterine longitudinal cold knife surgery more advantages,better endometrial healing,shorter operating time.
2017 Vol. 24 (29): 81-83 [
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Clinical effect evaluation of micro-implant anchorage nail in distal movement of maxillary full dentition
LIU Ming；GAO Zhen；WU Guang-yu；LIU Xiang；HU Wen-yun；PENG Yun-wen
ObjectiveTo observe the clinical effect of micro-implant anchorage nail in distal movement of maxillary full dentition in the treatment of patients with anterior teeth protrusion in classⅡ.MethodsFrom April 2014 to April 2016,45 patients with anterior teeth protrusion in classⅡtreated in Department of Orthodontics in our hospital were selected.They were randomly divided into group A (n=23)and group B (n=22).In group A,the technique of micro-implant anchorage nail in distal movement of maxillary full dentition was adopted,while in group B,molar by headgear was used.The moving distance of maxillary dental arch and changes of soft tissue before and after treatment were analyzed.ResultsThe therapeutic effect in all participants was satisfactory.The U1-X,U1-Y,and U6-Y in group A after treatment were higher than those in group B,with statistical differences(P＜0.05).No great difference was displayed in other indexes between the two groups(P＞0.05).ConclusionApplication of micro-implant anchorage nail can effectively move maxillary full dentition in a certain distance at advantages of stable anchorage and few side effects,and has a favorable effect in patients with anterior teeth protrusion in classⅡ.
2017 Vol. 24 (29): 84-87 [
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Observation of curative effect of fundus laser combined with Calcium Dobesilate in the treatment of diabetic retinopathy
HU Jun-hua； LIU Chun-lan； XIA Hou-li；LIAO Ying-lin ；HU Ming-sheng ；MAO Lei；YANG Chun-ping
ObjectiveTo analyze the effect of fundus laser combined with Calcium Dobesilate in the treatment of diabetic retinopathy.Methods60 patients with diabetic retinopathy treated in our hospital from October 2015 to September 2016 were selected as the research objects,randomly divided into treatment group and control group,30 cases in each group.The treatment group
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fundus laser combined with Calcium Dobesilate Capsules oral treatment,the control group was given fundus laser treatment.The clinical curative effect,systolic blood pressure,hemoglobin,stages of diabetic retinopathy and adverse reactions of the patients in two groups were compared and analyzed.ResultsThe total effective rate of the treatment group (93.3%)was significantly higher than that in the control group (83.3%),and the difference was statistically significant(P＜0.05).The number of diabetic retinopathy stage Ⅱ in treatment group was significantly less than that in the control group,the difference was statistically significant(P＜0.05).The incidence of adverse reactions in treatment group(0.00%)was significantly lower than that in the control group(3.33%),and the difference was statistically significant(P＜0.05).ConclusionFundus laser combined with Calcium Dobesilate has good effect on diabetic retinopathy.It can effectively improve the blood pressure level of the patients,and there is no obvious adverse reaction,which is worthy of promotion and application.
2017 Vol. 24 (29): 88-90 [
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Clinical effect of Ornidazole Mixture in adjunctive filling treatment of endodontic disease
YUAN Huan；CHENG Qin；WANG Wen-chao
ObjectiveTo investigate the clinical effect of Ornidazole Mixture in adjunctive filling treatment of endodontic disease.MethodsFrom June 2013 to May 2015,92 patients with endodontic diseases treated in our hospital were enrolled as the research objects,and the patients were evenly divided into control group and observation group in random,46 cases in each group.In the control group,regular adjunctive filling for treatment was used,while in the observation group,Ornidazole Mixture for temporary storage and permanent root canal filling was provided.The clinical efficacy and adverse reactions were compared in the two groups.ResultsAfter temporary storage in the two groups,the overall clinical effective rate in the observation group was 91.30%,much higher than that in the control group accounting for 69.57%.By permanent filling,the total effective rate in the observation group (86.97%)was higher than that in the control group (58.70%).Adverse reactions include toothache,swelling gum,occlusion discomfort,bad breath,and gastric discomfort,etc.The incidence of adverse reactions in the observation group was 21.74%,which was significantly lower than that in the control group accounting for 43.48%,the differences were statistically significant (P ＜0.05).ConclusionOrnidazole Mixture in adjunctive filling treatment of endodontic disease can remarkably improve clinical effect,reduce the incidence of adverse reactions and present with high safety.
2017 Vol. 24 (29): 91-93 [
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Clinical effect analysis of deep anterior lamellar keratoplasty in the treatment of herpes simplex keratitis
HUANG Hai；CHENG Han-xin；LUO Fang-lan
ObjectiveTo investigate the clinical effect of deep anterior lamellar keratoplasty(DALK)in the treatment of herpes simplex keratitis.MethodsA total of 70 patients with herpes simplex keratitis treated in our department from January 2014 to January 2016 were selected and randomly divided into the control group and the observation group,35 cases in each group.The control group was treated with penetrating keratoplasty(PKP),the observation group was treated with DALK.The surgical efficacy,visual acuity,graft rejection and survival,the incidence rate of complications and recurrence rate in the two groups were compared.ResultsThe total effective rate of the observation group was 97.14%,which was significantly higher than 82.86%of the control group,the difference was statistically significant(P＜0.05).There was no significant difference between the observation group and the control group in the equivalent spherical lens value and astigmatism(P＞0.05);The survival rate of skin grafts in observation group was 97.14%,and the rejection rate was 2.86%;the skin graft survival rate of the control group was 80.00%,and the rejection rate was 20.00%,the difference was statistically significant(P＜0.05).The incidence rate of complication such as secondary glaucoma,localized anterior synechia of iris,secondary cataract,posterior elastic layer micro perforation and posterior elastic layer wrinkle were significantly lower in the observation group than in the control group,the difference was statistically significant(P＜0.05).The recurrence rate of epithelial and stromal viruses in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).There was no recurrence of endothelial virus in the two groups.ConclusionDALK is effective in the treatment of herpes simplex keratitis,and it has high survival rate,low rejection rate,no obvious effect on postoperative visual acuity and low incidence of complications.It has positive clinical significance.
2017 Vol. 24 (29): 94-96 [
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The clinical curative effect of oral repair therapy in the treatment of congenital missing teeth patients
XIONG Bin；ZHAO You-xin；LUO Ming-le
ObjectiveTo investigate the clinical curative effect of oral repair therapy in the treatment of congenital missing teeth patients.MethodsFrom April 2016 to April 2017,78 patients with congenital missing teeth in our hospital were selected as the research object,all patients were given oral rehabilitation therapy,including routine examination,treatment plan,orthodontic treatment and repair treatment.The masticatory and language function scores,aesthetic satisfaction degree were compared before and after treatment,and the effect of oral rehabilitation therapy was analyzed.ResultsIn 78 patients,32 cases were cured,24 cases were markedly effective,18 cases were effective,4 cases were ineffective,the total effective rate was 94.87%.The scores of language function and masticatory function after treatment were significantly higher than those before treatment,with significant difference(P＜0.05).The aesthetic satisfaction degree after treatment was 93.59%,which was higher than 39.74%before treatment,and the difference was statistically significant(P＜0.05).ConclusionThe effect of oral repair therapy is significant in the treatment of congenital missing teeth,which can significantly improve the patient′s oral function,improve the appearance of the teeth,and effectively improve the patient′s satisfaction,which is worthy of clinical promotion and application.
2017 Vol. 24 (29): 97-99 [
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Effect of Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection on postoperative pain after laparoscopic appendectomy and its influence on platelet aggregation function
HE Guang-fan ；MA Jian-fa ；SHEN Yi-fei；XU Shan ；LUO Hui-jun ；LIU Jia
ObjectiveTo investigate the effect of Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection on postoperative pain after laparoscopic appendectomy and its influence on platelet aggregation function.Methods60 patients undergoing endoscopic appendectomy admitted into our hospital from February 2014 to December 2016 were evenly divided into two groups according to the random number method.30 patients were given normal saline 5 ml for intravenous injection after postoperative sober(the control group),and 30 patients were given Flurbiprofen Axetil Injection of 1 mg/kg for intravenous injection after postoperative sober(the study group).Resting visual analogue scale(VAS),active VAS score,and platelet aggregation function(PAG)were compared between the two groups before medication(T1),after 15 min medication(T2),after 30 min medication(T3),after 1 h medication(T4),after 2 h medication(T5),after 4 h medication (T6)and after 6 h medication (T7).The incidence of adverse reactions was statistically analyzed in both groups.ResultsThere was no significant difference in VAS score at T1and T2during resting and activity in both groups(P＞0.05).At T3,T4,T5,T6,T7,VAS score in the study group during resting and activity was significantly decreased,which was significantly lower than that in the control group(P＜0.05).There was no significant difference in PAG level at T1,T2,T3,T4,T5,T6and T7between the two groups (P＞0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P＞0.05).ConclusionFlurbiprofen Axetil Injection of 1 mg/kg for intravenous injection in patients receiving laparoscopic appendectomy can effectively inhibit postoperative pain,and will not affect platelet aggregation function,with no significant adverse reactions,which is worthy of promotion and application in clinic.
2017 Vol. 24 (29): 100-102 [
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Application effect of cocktail after knee joint replacement
FENG Dian-peng ；LIU Guang-hui ；JIANG Tao
ObjectiveTo analyze the application effect of cocktail after knee joint replacement.Methods60 patients underwent the unilateral total knee arthroplasty and 60 patients underwent the single knee replacement of knee joint in Department of Orthopaedics of the Second People′s Hospital of Dalian City from 2012 to 2016 were selected and they were divided into the two groups according to admission time,and there were 30 cases in each group.The observation group (admission after 2014)was given cocktail analgesia during operation,while the control group (admission before 2014)were not given any analgesic drugs during operation.NRS score of sicken knee at rest and during exercise after 24 h,48 h,3 d,7 d,14 d surgery and the incidence of adverse reaction were observed.ResultsFor total knee arthroplasty and single condylar joint replacement,NRS score at rest and during exercise after 24 h,48 h,3 d operation in the observation group were significantly lower than those of the control group,and there was a statistical difference (P＜0.05),and there was no statistical difference of NRS score at rest and during exercise after 7 d,14 d surgery between groups(P＞0.05).The incidence rate of adverse reaction the observation group after operation was lower than that of the control gorup,with statistically significant difference(P＜0.05).ConclusionAdopting cocktail therapy for postoperative analgesia in total knee arthroplasty and unicompartmental knee arthroplasty has definite analgesic effect,and the adverse reaction is fewer,the safety is higher,which can provide better choice for postoperative analgesia regimen in clinical work.
2017 Vol. 24 (29): 103-105 [
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Clinical application experience of visual laryngoscope in tracheal intubation after general anesthesia
ZHOU Chang-yuan
ObjectiveTo evaluate the application effect of visual laryngoscope in tracheal intubation after general anesthesia.Methods105 patients underwent tracheal intubation after general anesthesia treated in our hospital from July 2016 to July 2017 were selected and they they were divided into the control group and research group by drawing lots.In the research group(n=53),visual laryngoscope was applied for tracheal intubation,while in the control group(n=52),direct laryngoscope for tracheal intubation was used.The time of tracheal intubation and glottis exposure,and change of hemodynamics were compared between the two groups.ResultsThe time of tracheal intubation and glottal exposure in the study group[(9.65±1.21)s and(4.74±0.87)s respectively]was significantly shorter than that in the control group,and there was a statistical difference between groups(P＜0.05).The success rate of tracheal intubation at one time in the study group was 92.45%,which was higher than that in the control group (73.08%),and the incidence rate of complications in the study group was 3.77%,which was significantly lower than that in the control group(19.23%),and there was a statistical difference between groups(P＜0.05).During intubation,the heart rate and average arterial pressure was(75.60±8.97)times per minute and(97.46±8.97)mmHg respectively in the study group,which was significantly lower than that in the control group respectively[(90.84±10.58)times/min,(110.30±10.21)mmHg],and there was a statistical difference between groups(P＜0.05).There was no statistical difference of heart rate and average arterial pressure in patients between the two groups before induction and after 5 minutes intubation(P＞0.05).ConclusionVisual laryngoscope applied in tracheal intubation after general anesthesia obtains a great application effect and can effectively increase the success rate of tracheal intubation at one time,reduce the occurrence of various complications,and shorten the time of tracheal intubation and glottis exposure at the same time,and have mild impact on hemodynamics of patients.It is worthy of promotion.
2017 Vol. 24 (29): 106-108 [
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Application effect of Rivaroxaban after hip joint replacement
LING Xiao-peng
ObjectiveTo explore the effect of Rivaroxaban on the prevention of deep vein thrombosis (DVT)of lower extremity after hip joint replacement.MethodsFrom February 2015 to August 2016,84 patients with hip joint replacement treated in our hospital were selected as research objects.According to different therapeutic methods,they weredivided into the observation group and control group,and there were 42 cases in each group.In the control group,low molecular weight heparin (LMWH)was used 12 hours after surgery,while in the observation group,Rivaroxaban of oral administration 6 after hours surgery was adopted.The coagulation function indexes,changes of platelet count,D－dimer value,and volume of incision drainage before and after surgery,and incidence of adverse reactions and DVT were comparatively analyzed.ResultsPLT was(175.54±24.21)×109/L and activated partial thromboplast in time was(31.09±2.58)s after operation in the observation group,which was not displayed a significant difference between the two groups (P＞0.05).D－dimer level 1,3,7 d,and 14 day after surgery in the observation group were much lower than those in the control group (P＜0.05).In the observation group,the incidence of DVT after operation was not significantly different from that in the control group (P ＞0.05).The volume of incision drainage after operation in the observation group was(247.56±39.78)ml,and it was(252.34±42.24)ml in the control group,and there was no statistical difference (P＞0.05).The incidence of adverse reactions was 7.14%in the observation group,and it was 16.67%in the control group,and there was no statistical difference (P＞0.05).ConclusionFor patients after hip joint replacement,Rivaroxaban applied can remarkably improve anticoagulant effect and has a tantamount effect on preventing DVT formation as LMWH,but more effective and safe in the former.
2017 Vol. 24 (29): 109-111 [
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Effect of Compound Bismuth and Magnesium Granules quadruple therapy on Hp-eradication
WANG Heng-cui；YU Bo-la；DONG Qi-rong ；YANG Xiang-yu ；QIN Ying
ObjectiveTo observe the effect of Hp eradication of Compound Bismuth and Magnesium Granules quadruple therapy on chronic gastritis and peptic ulcer.Methods150 patients with Hp infection treated in People′s Hospital of Xishuangbanna Prefecture from January 2012 to December 2015 were selected and they were divided into 3 groups,and there were 50 cases in each group.The standard triple group was given Rabeprazole,Amoxicillin,Clarithromycin for 14 days.Compound Bismuth and Magnesium Granules quadruple group was added Compound Bismuth and Magnesium Granules,while Bismuth Potassium Citrate quadruple group was added Bismuth Potassium Citrate for oral administration for 14 days on the basis of the standard triple treatment respectively.Hp eradication,remission of symptoms and adverse reaction of the three groups were observed.ResultsHp eradication rate and symptoms remission rate of abdominal pain and abdominal distension and acid belching of Compound Bismuth and Magnesium Granules quadruple group were higher than those of standard triple group,and there were notable statistical differences(P＜0.01).Hp eradication rate of Compound Bismuth and Magnesium Granules quadruple group was also higer than that of Bismuth Potassium Citrate quadruple group,and there was a statistical difference(P＜0.05).There was a statistical difference of symptoms remission rate of abdominal pain and distension of Bismuth Potassium Citrate quadruple group and standard triple group(P＜0.05).The adverse reaction among three groups had no statistical significance (P＞0.05).ConclusionCompound Bismuth and Magnesium Granules quadruple therapy in the clinical treatment on Hp－eradication and symptoms remission has a better effect than the other groups.What′s more,it does not add adverse reaction,and it has a certain advantage and a better safety in the treatment of Hp eradication.
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Effect observation of Shuanghuanglian Oral Liquid (only for children)as an adjunctive therapy on herpangina
LI Ya-juan
ObjectiveTo observe the clinical effect of Shuanghuanglian Oral Liquid(only for children)as an adjunctive therapy on herpangina.MethodsFrom January 2016 to April 2017,130 pediatric patients with herpangina treated in our hospital were selected and they were divided into 3 groups by a random number table method.In group A(n=43),intravenous drip of Xiyanping Injection was used,and in group B (n=43),Ribavirin Injection for intravenous drip was used,while in group C (n=44),on the basis of the group A,Shuanghuanglianoral Liquid (only for children)was added.It was observed for 5 days by continuous medication.The total effective rate and recovery time of symptoms among three groups were compared.ResultsThe total effective rate was 100.00%,which is greatly higher than that in group A(86.04%)and group B(76.74%)with statistical differences(P＜0.05).In group C,the time of abating fever,herpesdisappearing,and food refusal and drooling was much shorter in comparison with those in group A and group B,with statistical differences(P＜0.05).ConclusionCombination of Shuanghuanglianoral liquid (only for children)and Xiyanping injection can obtain a remarkable effect on treating pediatricherpangina,which can alleviate children patients′clinical signs sooner compared with those only by Xiyanping or Ribavirin,which is worthy of clinical further promotion and application.
2017 Vol. 24 (29): 115-117 [
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Effect observation of Huangqi Danshen Injection combined with antibiotics treating acute pelvic inflammatory disease
LI Jian-mei
ObjectiveTo observe the effect of Huangqi Danshen Injection combined with antibiotics treating acute pelvic inflammatory disease (PID).MethodsFrom January to June 2017,81 patients with acute PID admitted into our hospital were enrolled and divided into control group (n=40)and observation group (n=41).In the control group,Penicillin combined with Metronidazole was used,while in the observation group,on the basis of the control group,Huangqi Danshen Injection was added.The efficacy－related indicators and adverse reactions after one week medication between the two groups were compared.ResultsIn the observation group,the average score of fever,abdominal pain,and leucorrhea after therapy were lower than those in the control group (P＜0.05).Indicators including high sensitivity C－reactive protein,white blood cell count,and size of the mass were smaller than those in the control group (P＜0.05).The clinical therapeutic effect in the observation group was better than that in the control group (P＜0.05).No allergic reactions or other adverse reactions occurred.ConclusionHuangqi Danshen Injection combined with antibiotics in the treatment of acute PID can obtain a remarkable effect without serious adverse reactions,and is worthy of wide promotion in clinic.
2017 Vol. 24 (29): 118-120 [
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134
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Effect analysis of Sini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris
TAN Ming-qin
ObjectiveTo study the efficacy of Sini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris.Methods74 patients with variant angina pectoris in the Central Hospital of Zibo Mining Group Co.,LTD.from June 2014 to April 2017 were selected and divided into the combination group and the control group by random number table method,37 cases in each group.The combination group was treated with Sini Decoction combined with Isosorbide Mononitrate,the control group was treated with Isosorbide Mononitrate.During the course of treatment,the frequency and duration of angina pectoris in the two groups were observed.2 weeks after treatment,cardiac function indexes and serum cytokines were determined in the two groups.ResultsThe frequency of angina pectoris in the combined group was significantly less than that in the control group and the duration of each attack in the combined group was significantly shorter than that in the control group,with significant difference (P＜0.05).After 2 weeks of treatment,cardiac function indexes CO,EF of the combination group was significantly higher than that of the control group,with significant difference(P＜0.05);serum tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),intercellular adhesion molecule-1(ICAM-1)contents in the combination group was significantly lower than that in the control group,with significant difference(P＜0.05).ConclusionSini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris can reduce angina pectoris,improve heart function and inhibit inflammatory reaction.
2017 Vol. 24 (29): 121-123 [
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163
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Clinical observation of Yishen Huayu Paizhuo Decoction combined with Compound α-Ketoacid Tablets on treating chronic renal failure
PENG Yong；ZHOU Xia
ObjectiveTo explore the clinical effect of Yishen Huayu Paizhuo Decoction combined with compound α-ketoacid tablets in the treatment of chronic renal failure (CRF).MethodsA total of 66 CRF patients treated in our hospital from July 2013 to June 2016 were selected and randomly divided into the medication-only group and the combined group,33 cases in each group.The symptomatic supportive treatment was provided in the two groups.In the medicationonly group,Compound α-Ketoacid Tablets was used,while in the combined group,on the basis of the medication-only group,Yishen Huayu Paizhuo Decoction was added.The indicators of renal function and nutrition indicators in the two groups were compared.ResultsThe levels of serum urea nitrogen,serum creatinine,and endogenous creatinine clearance in the two groups after treatment were lower than that before treatment,the levels of serum urea nitrogen,serum creatinine,and endogenous creatinine clearance in the combined group after treatment was lower than that in the medicationonly group,with significant difference (P＜0.05).The nutrition indicators including body weight,arm muscle circumference,thickness of skin-fold of musculus triceps brachii,hemoglobin,and serum albumin in the two groups after treatment were better than that before treatment,the nutrition indicators including body weight,arm muscle circumference,thickness of skin-fold of musculus triceps brachii,hemoglobin,and serum albumin in the combined group after treatment were better than that in the medication-only group,with significant difference (P＜0.05).ConclusionFor CRF patients,application of Yishen Huayu Paizhuo Decoction combined with Compound α-Ketoacid Tablets can not only improve patient′s renal function,but also better their nutritional status.
2017 Vol. 24 (29): 124-126 [
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153
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Feasibility analysis of Mecobalamin Injection combined with Modified Shaoyaogancao Decoction and Taohongsiwu Decoction in the treatment of diabetic peripheral neuropathy
WEI Hai-ying；LIU Shu-jun
ObjectiveTo investigate the clinicaleffectofMecobalamin Injection combined with Modified Shaoyaogancao Decoction and Taohongsiwu Decoction in the treatment of diabetic peripheral neuropathy.Methods80 patients with diabetic peripheral neuropathy treated in our hospital from February 2014 to December 2016 were selected and divided into the control group and the study group according to the random number table method,40 cases in each group.The control group was treated with Mecobalamin Injection,and the study group was treated with Mecobalamin Injection combined with Modified Shaoyaogancao Decoction and Taohongsiwu Decoction.The clinical curative effect,the incidence of adverse reaction,symptoms score,and the level of motor nerve conduction velocity and(MNCV),sensory nerve conduction velocity(SNCV),homocysteine(Hcy),Cystatin C(Cys-C)levels before and after intervention in the two groups were compared.ResultsThe total effective rate of the patients in the study group (92.50%)was significantly higher than that in the control group(70.00%),with significant difference(P＜0.05).The MNCV and SNCV levels of the patients in the study group after intervention were significantly higher than those in the control group,with significant difference (P＜0.05).The levels of Hcy,Cys-C and symptom scores in the study group after intervention were significantly lower than those in the control group,with significant difference (P＜0.05).There were no adverse reactions in the two groups.ConclusionMecobalamin Injection combined with Modified Shaoyaogancao Decoction and Taohongsiwu Decoction in the treatment of diabetic peripheral neuropathy can significantly improve the clinical efficacy,improve nerve conduction velocity and symptom score,reduce serum Cys-C and Hcy levels.
2017 Vol. 24 (29): 127-129转132 [
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Clinical effect of Shenling Hewei Decoction combined with western medicine on treating gastric ulcer
HUANG De-chang；CHEN Fang
ObjectiveTo explore the clinical effect of Shenling Hewei Decoction combined with western medicine on treating gastric ulcer.MethodsFrom April 2015 to February 2017,124 patients with gastric ulcer treated in our hospital were randomly divided into the control group and the observation group by odd/even numbers.Patients in the control group were treated with triple therapy,while in the observation group,they were provided with Shenling Hewei Decoction and western medicine.The treatment effect,the clearance rate of Helicobacter pylori(Hp),the recurrence rate after 6 months,and the incidence rate of adverse reaction were compared in the two groups.ResultsThe total effective rate in the observation group was 95.2%,which was higher than that in the control group(83.9%),with significant difference(P＜0.05).There was no significant difference in the clearance rate of Hp between the two groups after treatment(P＞0.05).The recurrence rate of the observation group was lower than that in the control group,with significant difference (P＜0.05).There was no significant difference in the incidence rate of adverse reaction between the two groups (P＞0.05).ConclusionThe effect of combination of Shenling Hewei Decoction and western medicine on treating gastric ulcer is remarkable,with low incidence rate of adverse reactions,which is worthy of promotion.
2017 Vol. 24 (29): 130-132 [
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149
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Influence of patients′participation in patient safety pattern on the maintenance of PICC catheter patients
HAN Lian-ying ；CHENG Shu-hua；NI Dan； LIU Fang-yuan； PU Qi-lin ；ZHENG Chun-ying ；LIU Shan ；LIANG Juan
ObjectiveTo investigate the effect of patients′participation in patient safety model on the maintenance of PICC catheter patients.Methods50 PICC catheter patients who were hospitalized in Department of Oncology of a GradeⅢA Hospital from January to June in 2015 was selected as the control group,while,50 patients who underwent PICC catheter from July to December in 2015 with willingness to be involved in the maintenance of the catheter were selected as the experiment group.Patients in the control group underwent PICC catheter by intravenous therapy nurse and the primary nurse undertook the responsibility of maintenance and management as well as establishment and maintenance of the archives;on the basis of the control group,patients′participation in patient safety model was added in the experiment group to improve patients′safety awareness of active participation and cooperate with medical staff for catheter maintenance.During intubation,anonymous questionnaire surveys were adopted in two groups to make investigation and analysis,and the incidence of PICC complications of the two groups was observed.ResultsThrough the application of patients′participation in patient safety model,the patients′intention of participation in patient safety of the experiment group was significantly improved,with significant significance(P＜0.01).There was no significsnt significance in PICC complications between the two groups,such as local infection,thrombosis and catheter breakage(P＞0.05).The incidence of PICC complications of the experiment group,such as phlebitis,catheter blockage and catheter prolapse,was significantly lower than that of the control group,with significant difference (P＜0.05).ConclusionApplication of patients′participation in patient safety model can promote patients′intention of safety behavior in involvement in catheter maintenance after PICC catheterization.The nurse and patient work together for catheter maintenance can effectively reduce the incidence of PICC complications and decrease the clinically unplanned extubation.
2017 Vol. 24 (29): 133-136 [
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123
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Epidemiological study on unintentional injuries in children aged 0-6 years in Shaoguan District
ZHU Jun；LONG Li-hua；CAO Shan-hong；QIU Shao-zhi；HUANG Guo-ji；MA Guo-dong；WU Qiang
ObjectiveTo investigate the epidemiological status on unintentional injuries among children aged 0-6 years in Shaoguan District,so as to provide reliable evidence for reducing injury and establishing relevant intervention measures.MethodsThe questionnaire was adopted to make an investigation of unintentional injuries among children aged 0-6 years from January to December in 2015 in Shaoguan District,including the basic situation of the family,occurrence of unintentional injuries in children,injury cause,injured season,medical expenses and other information.ResultsAmong the 400 infants and children who suffered from unintentional injuries,there were 238 boys (accounting for 59.5%)and 162 girls(accounting for 40.5%);there was significant statistical difference in the incidence of unintentional injuries between boys and girls(χ2=17.78,P＜0.001);there were 256 infants and children aged 4-6 years suffered from unintentional injuries,accounting for 64.0%;while,144 cases infants and children aged 0-4 years had unintentional injuries,accounting for 36.0%;the incidence of unintentional injury of infants and children aged 4-6 years was significant higher than that of infants and children aged 0-4 years,with statistical significant difference (χ2=19.64,P＜0.001).The top three injury types of boys and girls were fall injuries,animal bites and burns,accounting for 24.0%,18.5%and 17.5%,respectively.During the spring,summer,fall and winter seasons,the incidence of unintentional injuries in spring and summer was the highest,accounting for 62.5%;and the average medical expenses of all the injured children totaled 3280 Yuan,accounting for 21.7%of the total income of the family.ConclusionUnintentional injuries seriously affect the health status of infants and children aged 0-6 years in Shaoguan District,which will cause heavy economic losses to families and society.Therefore,targeted prevention measures are particularly important.
2017 Vol. 24 (29): 137-139 [
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150
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Survey analysis of bone mineral density of middle-aged and old women in Xihu District of Nanchang City
WU Shao-yang
ObjectiveTo investigate the bone mineral density(BMD)of middle-aged and old women in Xihu District of Nanchang City,and to explore the incidence and influential factors of osteoporosis(OP)in this district.MethodsA total of 800 middle-aged women who
received：
health examination in our hospital from January to October in 2016 were enrolled.BMD of the distal one-third of the radius and the ulna in non-dominant forearm was measured using dual energy X-ray absorptiometry (DEXA).Relationship of BMD and age,body mass index (BMI),menopause status,outdoor sports,sunshine,milk drinking and other related factors were analyzed.ResultsThe incidence of OP in 40-49 years old group,50-59 years old group,60-70 years old group were 12.85%,21.72%,30.29%,there was significant difference among each groups(P＜0.05).The incidence of OP in low BMI group was 51.11%and in normal BMI group was 15.08%,with significant difference (P＜0.05).The incidence of OP in premenopause was 11.88%,which was lower than 27.47%in menopause,with significant difference (P＜0.05).The incidence of OP in outdoor sports,sunshine,milk drinking was lower than those no outdoor sports,no sunshine,no milk drinking,with significant difference (P＜0.05).ConclusionThe incidence of OP is increased when the age increasing and postmenopausal in middle-aged women.Proper outdoor sports and good lifestyle can slow down BMD.Early intervention prevention and good lifestyle are important to the prevention of OP.
2017 Vol. 24 (29): 140-142 [
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157
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Investigation and analysis of cognition status of knowledge about puerperal health care in puerperium
Chen Ya-li
ObjectiveTo analyze the cognition status of puerperal health care related knowledge and the factors affecting maternal cognition status,and to provide a strong basis and reference for the implementation of clinical nursing work.Methods89 puerperal women from May 2016 to February 2017 in our hospital were selected as objects of this observation.The cognition status of related knowledge of health care knowledge,breast feeding rate,neonatal care knowledge awareness,activity time,balanced nutrition diet,maternal self recovery nursing were investigated,and the influence of the understanding of health knowledge on personal condition was analyzed.ResultsThere was significant difference in the knowledge of puerperal health care knowledge between different age groups(P＜0.05).The awareness of maternal health knowledge was higher in women with high educational level than that of women with low educational level,with significant difference (P＜0.05).The awareness rate of maternal health care in urban areas was better than that in rural women,with significant difference (P＜0.05).The awareness of health knowledge among the parturients was obviously superior to that of primipara,with significant difference (P＜0.05).ConclusionMaternal awareness of puerperal health knowledge is mainly affected by maternal age,number of deliveries,cultural level and urban and rural living environment,maternal health education should be taken according to the actual situation to improve maternal health knowledge awareness rate.
2017 Vol. 24 (29): 143-145 [
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155
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Application of safety transfer program management in the transportation of critically ill patients in hospital
HUANG Fang ；ZHU Hui-juan； LI Shu-xia
ObjectiveTo analyze and study the application effect of safety transfer program management in the transportation of critically ill patients in hospital.Methods720 patients from January 2015 to September 2016 in our hospital were selected and divided into the observation group (from January to November 2015)and the control group(from December 2015 to September 2016)according to the admission,and each group was 360 cases.Patients in the observation group were given safety transfer program management,and patients in the control group were given general transfer program management.The transfer time,patient satisfaction degree,and the incidence rate of adverse event in the two groups were compared.ResultsThe transfer time,patient satisfaction degree,and the incidence rate of adverse event in the observation group were respectively (11.98±3.14)min,94.17%and 1.12%,which were respectively (19.39±3.77)min,87.50%and 4.47%in the control group,and the difference was significant between the two groups(P＜0.05).ConclusionUsing safety transfer program management in critically ill patients can shorten the time of transportation and reduce the incidence of adverse events,increase patient satisfaction degree,which with great significance for the development of hospital and the life quality of patients.It is worthy of clinical promotion and application.
2017 Vol. 24 (29): 146-148 [
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156
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The effect of PDCA cycle in risk control management
LAN Jian-yun ；ZHOU Yun-ying ；LIU Mei-ying； GUAN Xi-hong
ObjectiveThe explore the effect of PDCA cycle applied in risk control management,to provide the basis for clinical nursing management.MethodsPDCA cycle was appliedin risk control managementby the interventional treatment center from June 2015 to June 2016.The score of nursing quality (including nursing management,specialist nursing,safety management,hospital infection,education and training 5 indicators),department performance evaluation score and patient satisfaction score were compared before and after the implementation of PDCA cycle.ResultsNursing quality score after PDCA implementation(such as nursing management,specialized nursing,safety management,hospital infection and education training)were significantly higher than those before PDCA implementation,the difference was statistically significant(P＜0.05).The performance evaluation score and satisfaction degree score of patients were higher than those before the implementation of PDCA,the difference was statistically significant(P＜0.05).ConclusionThe implementation of PDCA cycle can effectively improve the quality of risk control management,improve the performance and patients′satisfaction degree of the department,and ensure the quality and safety of nursing.It is worthy of clinical promotion and application.
2017 Vol. 24 (29): 149-151 [
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128
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Application of the three four two two check system with four right as the core in the decreasing of the medication errors
FU Lian-ying； YANG Hai-lan； LIAO Ai-min
ObjectiveTo explore the application effect of the “three four two two check system with four right as the core”in the application of decreasing of the medication errors.MethodsThere were 19782 patients in 2015 and 19793 patients in 2016.The nurses carried out the medicine with the check system in 2016,which were three times check,four rights,two ways,two person check were built into the “three four two two check system with four right as the core”,and were draw into the figure.The incidence of medication errors and near medication errors after(in 2016)and before(in 2015)the application of the check system were compared.ResultsAfter the application of the check system,the incidence rate of medication errors and near medication errors were 0.10‰and 0.50‰,which were lower than 0.45‰and 1.60 ‰ before the application of the check system,the differences were statistically significant(P＜0.05,P＜0.01).ConclusionThe application of"the three four two two check system with four right as the core"can decrease the medication errors.
2017 Vol. 24 (29): 152-154 [
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146
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The application effect of time-section appointment registration in outpatient clinic in nursing triage management
CHEN Jin
ObjectiveTo explore the application effect of time－section appointment registration in outpatient clinic in nursing triage management.Methods26 800 patients conducted appointment registration in outpatient clinic of our hospital from January to June 2016 were selected.According to the registration procedure,they were divided into the experimental group and control group,and there were 13 400 cases in each group.In the control group,the related appointment was conducted through traditional registration,while in the experimentalgroup,the related appointment was conducted through time－section appointment registration.The doctor－patient dispute rate,the satisfaction degree of patients,and time－spending on visiting doctors were calculated in the two groups.ResultsIn the experimental group,the doctorpatient dispute rate was 1.49%,which was significantly lower than that in the control group(5.97%)(P＜0.05).The satisfaction degree of patients in the experimental group was 96.27%,which was much higher than that in the control group(74.63%)(P＜0.05).In the experimental group,the average time－spending on visiting doctors was (45.27±11.23)min,while it was(89.63±15.19)min in the control group,and there was a statistical difference (P＜0.05).ConclusionTimesection appointment registration in outpatient clinic can effectively reduce the doctor－patient dispute rate,improve the satisfaction degree of patients for hospital and the visiting efficiency of hospital,which is worthy of promotion and application in outpatient clinics of various major hospitals.
2017 Vol. 24 (29): 155-157 [
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140
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Research on application effect of flexible management in obstetrics and gynecology department nursing management practice
XIAO Yu-juan；ZHANG Shi-bing
ObjectiveTo study the application effect of flexible management in obstetrics and gynecology department nursing management practice.Methods100 patients of obstetrics and gynecology treated in our hospital from January 2016 to June 2017 were selected as the subjects,and the patients were divided into two groups according to the order of treatment,and there were 50 cases in each group.The patients in the control group (treatment time was from January to September 2016)were given the routine nursing management while the patients in the observation group(treatment time was from October 2016 to June 2017)were treated with flexible management.The nursing quality,nursing satisfaction degree,nursing error rate and complaint rate were compared in patients between the two groups.ResultsThe score of service process,nursing technology,health education,nursing attitude of nursing staff and quality score of 5 items of nursing quality score were better than those of the control group(P＜0.05),the total nursing satisfaction degree(92.00%)was higher than that of the control group (P＜0.05),nursing error rate(2.00%)and complaint rate (2.00%)were lower than those in the control group (P＜0.05).ConclusionThe implementation of flexible management in obstetrics and gynecology nursing management has a good application effect,which will help to improve the nursing quality and satisfaction degree of patients,reduce the occurrence of nursing error and its clinical promotion application value is high.
2017 Vol. 24 (29): 158-160 [
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156
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Study on application of modified cuff compression hemostasis sphygmomanometer after interventional therapy for hepatocellular carcinoma
WANG Shu-fang；HE Ye；PAN Yun
ObjectiveTo investigate the application effect of modified cuff compression hemostasis sphygmomanometer after interventional therapy for hepatocellular carcinoma.Methods200 patients with liver cancer treated by interventional surgery in our hospital from February 2015 to December 2016 were selected for the study,and randomly divided them into observation group and control group according to the random number table method,and 100 cases in each group.The observation group was treated with modified sphygmomanometer for hemostasis,the control group was treated with routine artificial compression and sandbag compression.The time of compression and hemostasis,the incidence of complications and comfort were compared between the two groups.ResultsThe hemostasis time of the observation group[(14.5±5.2)min]was lower than that of the control group[(24.3±7.8)min],the difference was statistically significant(P＜0.05).The incidence of complications such as hemorrhage,hematoma and thrombosis in the observation group (7%)was lower than that in the control group (31%),and the difference was statistically significant(P＜0.05).The incidence of back pain and dysuria in the observation group(19%,14%)were lower than those in the control group(33%,39%),and the sleeping time of the first day after surgery of the observation group was longer than that of the control group,and the difference were both statistically significant(P＜0.05).ConclusionThe hemostatic effect of modified cuff compression hemostasis sphygmomanometer after interventional therapy for hepatocellular carcinoma is not only good,and with fewer complications,but also can improve the comfort of patients.
2017 Vol. 24 (29): 161-163 [
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Effects of TCM rehabilitation nursing combined with conductive education and exercise on postoperative pulmonary function and quality of life in non-small cell lung cancer patients
RAO Ju-fang； XIE Yan； XIONG Han-peng
ObjectiveTo investigate the effects of TCM rehabilitation nursing combined with conductive education and exercise on postoperative pulmonary function and quality of life in non－small cell lung cancer patients.MethodsEightsix non－small cell lung cancer patients who were admitted and underwent surgery in our hospital from August 2013 to July 2016 were selected as objects,they were divided into two groups according to the random number table method,each of which was 43 cases.The control group
received：
conventional care,the observation group received TCM rehabilitation nursing combined with conductive education and exercise in addition to conventional care.The pulmonary function and quality of life before and after nursing of two groups were compared.ResultsBefore nursing,the FEV1,FVC,PEF and quality of life scores of the two groups were compared,the differences were not statistically significant(P＜0.05).After nursing,the FEV1,FVC,PEF and quality of life scores in the observation group were significantly higher than those in the control group,and the differences were statistically significant (P ＜0.05).ConclusionTCM rehabilitation nursing combined with conductive education and exercise could effectively improve postoperative pulmonary function and quality of life of non－small cell lung cancer patients.
2017 Vol. 24 (29): 164-166 [
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143
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Application effect of multiplex nursing intervention in adolescents with schizophrenia
YAN Lan
ObjectiveTo investigate the application effect of diversified nursing intervention in improving self－management ability in adolescents with schizophrenia.MethodsFrom March 2015 to December 2016,134 cases adolescents with schizophrenia treated in our hospital were selected as the research objects,and were divided into multivariate group and routine group according to different nursing intervention methods,67 cases in each group.The patients in the routine group were given routine nursing intervention,and the multivariate group was given diversified nursing intervention on the basis of the routine group,and the two groups were all treated with antipsychotic drugs.After treatment,two groups of patients rehabilitation self－management ability and nursing satisfaction were compared.ResultsBefore intervention,the self－management ability and rehabilitation effect score of the two groups were compared,and the differences were not statistically significant(P＞0.05).After intervention,the scores of self－management ability and rehabilitation effect of the patients in the multivariate group were higher than those in the conventional group,the differences were statistically significant(P＜0.05).After intervention,the satisfaction of the nurses in the multivariate group (95.52%)was higher than that in the routine group (80.60%),and the difference was statistically significant(P＜0.05).ConclusionNursing intervention can improve the diversification of adolescent schizophrenia patients self management ability,the effect of rehabilitation and nursing satisfaction,so that patients can better control of psychiatric symptoms,return to society can bear the social responsibility and obligation,clinical application has achieved good results,it is worth of wide application.
2017 Vol. 24 (29): 167-169 [
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Application of comprehensive nursing in patients with surgical incision infection
CHEN Jing
ObjectiveTo analyze the application effect of comprehensive nursing in patients with surgical incision infection.Methods108 patients with operation incisional infection from October 2,2015 to February,5 2016 treated in our hospital were selected and the patients were randomly divided into two groups.The control group(54 patients)was given routine nursing,whlie in the observation group 54 patients with comprehensive nursing.Infection control rate,symptom improvement time,operation time,hospitalization time after nursing in patients between the two groups were compared.ResultsThe infection control rate was 92.59%in the observation group,and it was higher than that in the control group(74.07%)(P＜0.05).The time of symptom improvement was(8.23±1.05)d,the operation time was(45.27±10.15)min,hospitalization time was(12.45±1.28)d in the observation group after treatment were shorter than those of control group[(12.11±1.28)d,(60.45±11.28)min,(16.37±1.18)d],and there were a statistical difference(P＜0.05).ConclusionThe comprehensive nursing in patients with surgical incision infection can not only shorten the time of hospitalization,the operation time,the improvement time of symptoms,but also control the infection of patients.
2017 Vol. 24 (29): 170-171转178 [
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Effects of different intervention methods on relieving pain of neonatal plantar blood sampling
AI Mei-lian
ObjectiveTo investigate the clinical effect of different interventions methods on relieving pain of neonatal plantar blood sampling.MethodsFrom January 2015 to October 2016,91 cases of plantar blood in healthy term newborns treated in our hospital were selected as the research objects and were divided into two groups according to the differences in the intervention methods in blood sampling.Definition of
received：
touch nursing intervention in 45 patients as the control group,the 46 cases of non nutritive sucking nursing intervention of patients as the observation group.The nursing method of pain relief effect of two group were compared.ResultsThe decrease of heart rate,respiration,blood pressure and oxygen saturation of the observation group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).The NICU score of neonates in the observation group[(3.5±0.6)points]was significantly lower than the control group[(2.4±0.4)points],and the difference was statistically significant(P＜0.05).The average bleeding time of neonates in the observation group was shorter than that in the control group,the average bleeding was greater than the control group,and the differences were statistically significant(P＜0.05).ConclusionNon nutritive sucking clinical effect of nursing intervention on pain relief of plantar blood newborns significantly,worthy of promotion.
2017 Vol. 24 (29): 172-174 [
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Application of quality nursing model in gestational diabetes mellitus with gestational hypertension
LIU Fen ；CHEN Qiu-hua ；HU Jian-mei
ObjectiveTo investigate the application effect of high quality nursing model on gestational diabetes mellitus complicated with hypertensive disorder,and to expound the value and significance of clinical application of quality nursing program.Methods70 puerperae of gestational diabetes mellitus with gestational diabetes mellitus
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in our hospital from January to December 2016 were selected as objects and were randomly divided into control group and observation group,35 cases in each group.The control group was treated with routine nursing and the observation group was treated with high quality nursing intervention.The maternal satisfaction,the changes of blood glucose and blood pressure before and after maternal care,the pregnancy outcomes of the two groups were compared.ResultsAfter nursing,the blood glucose and blood pressure indexes of the observation group were lower than the control group,and the differences were statistically significant(P＜0.05).The total satisfaction of the puerperae in the observation group was significantly higher than the control group,and the difference was statistically significant(P＜0.05).The total incidence rate of adverse pregnancy outcomes was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).ConclusionQuality care program has significant clinical value and significance,it is conducive to maternal blood glucose and blood pressure significantly improved,improve the outcome of pregnancy has important positive significance,can significantly reduce the appearance rate of malformations and huge children,but also effectively improve the maternal nursing satisfaction,to a certain extent,can significantly improve the tension between doctors and patients,it is worthy of clinical application.
2017 Vol. 24 (29): 175-178 [
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156
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179
Nursing strategy and effect analysis of postoperative pain in ankle joint fracture
YANG Yin-hua；LIU Li-na；CHEN Jing
ObjectiveTo investigate the nursing countermeasures and clinical effects of postoperative pain of ankle fracture.Methods70 patients with ankle fractures who were treated in the Department of orthopedics of the Third People′S Hospital of Wuxi City from March 2014 to March 2017 were selected as the study subjects.There were 35 cases of control group and 35 cases of observation group according to the different nursing methods.The control group were given routine nursing measures,the observation group was given routine nursing plus pain nursing.The pain relief rate,nursing satisfaction,the incidence of nursing disputes of patients in the two groups were compared.ResultsThe total pain relief rate in the observation group(94.29%)was significantly better than the control group(74.29%),and the difference was statistically significant (P ＜0.05).The postoperative pain nursing satisfaction in the observation group(97.14%)was significantly higher than that in the control group(77.14%),and the difference was statistically significant(P＜0.05).The incidence of nursing disputes in the observation group(2.86%)was lower than the control group(17.14%),and the difference was statistically significant(P＜0.05).ConclusionPatients with ankle fracture postoperative pain,routine care and not a single complete remission in patients with pain,joint pain relieving effect of pain nursing in ankle fracture,it is worth in the clinical application of recommendation.
2017 Vol. 24 (29): 179-181 [
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159
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182
Application of standardized high-quality nursing in vocal cord polyp removal
DENG Mei-huan
ObjectiveTo investigate the application of standardized quality nursing and routine nursing model in vocal cord polyp removal.MethodsA total of 300 patients were randomly divided into control group(n=150)and study group(n=150).The patients in the control group were treated with routine nursing.The patients in the observation group were given standardized quality nursing.The sleep status,quality of life,satisfaction with the nursing work and 3 months after the vocal cord recovery were compared of patients in the two groups.ResultsAfter treatment,the sleep status and quality of life of the two groups were better than those of before nursing,the sleep status and quality of life were lower in the observation group than those in the control group,and the differences were statistically significant(P＜0.05).The satisfaction degree of the nursing staff in the observation group (98.00%)was significantly higher than that in the control group(76.00%),and the difference was statistically significant(P＜0.05).After 3 months follow－up,the recovery of vocal cord in the observation group was significantly better than that in the control group,the difference was statistically significant(P＜0.05).ConclusionIn the vocal cord polyp removal in the use of standardized quality care,can significantly improve the quality of sleep in patients with improved quality of life and satisfaction with the degree of care,3 months after the vocal recovery is good,worthy of clinical promotion.
2017 Vol. 24 (29): 182-184 [
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134
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185
Effect of 4C continuous nursing management model on the rehabilitation of stroke patients
JIANG Zhi-li；LI Run-xiang
ObjectiveTo investigate the nursing effect of 4C continuous nursing management mode in patients with stroke rehabilitation.Methods86 patients with stroke from September 2015 to March 2017 in our hospital were selected as objects and divided into the observation group(n=43)and control group(n=43)according to the random number method.The patients in control group were given regular nursing plans.Patients in the observation group were
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the additional 4C continue nursing management mode.The evaluation of three index,such as nursing after the patients daily behavior and compliance the medical behavior and nursing satisfaction of two groups were compared.ResultsThe scores of daily living ability of the patients in the observation group were significantly higher than those in the control group at first,second and 6 months after discharge respectively,and the differences were statistically significant(P＜0.05).The score of compliance in the observation group after nursing was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The satisfaction degree of the patients in the observation group(90.1%)was significantly higher than that in the control group(76.7%),and the difference was statistically significant(P＜0.05).ConclusionThe 4C continuity management model can greatly improve ability of stroke patients the daily life and improve the satisfaction of nursing,which is worthy of clinical research in nature.
2017 Vol. 24 (29): 185-187 [
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171
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188
Application effect of systematic perioperative nursing in elderly patients with gallstones
LIN Xiao-qin
ObjectiveTo investigate the application effect of systematic perioperative nursing measures in elderly patients with gallstones.MethodsA total of 86 elderly patients with gallstones were enrolled in our hospital from March 2015 to March 2017.By a random number table,these patients were evenly divided into research group and control group,43 cases in each group.Patients in the control group were treated with general nursing measures,while in the research group,the systematic perioperative nursing measure was used.The time of being off bed,discharge time,incidence of complications,and nursing satisfaction in the two groups were comapred.ResultsIn the research group,the time of being off bed[(31.58±6.33)d]and discharge time[(8.42±2.09)d]were shorter than those in the control group[(53.74±7.10)d,(12.73±2.88)d],the differences were statistically significant(P＜0.05).In the research group,the therapeutic effective rate(97.67%)was higher than that in the control group(81.40%),the difference was statistically significant(P＜0.05).The incidence of complications(4.65%)and nursing satisfaction(97.67%)in the research group were higher than those in the control group(18.60%,83.72%)respectively,the difference was statistically significant(P＜0.05).ConclusionApplication of the comprehensive perioperative nursing measures in the elderly patients with gallstones can obtain an optimal effect and effectively promote patient′s recovery,which is worthy of promotion.
2017 Vol. 24 (29): 188-190 [
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144
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75
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191
Influence of early swallowing function training on swallowing function in patients with post-stroke dysphagia
LI Jiang-xia
ObjectiveTo investigate the influence of early swallowing function training on swallowing function in patients with post－stroke dysphagia.MethodsForty－eight patients with stroke dysmenorrhea wereselected from the hospital from February 2013 to December 2016,and weredivided into control group(n=44)and observation group(n=44)according to the random number table method.Routine treatment and care were given the two groups.On this basis,early swallowing function training was added in the observation group.Treatment effect and the improvement and swallowing function were compared between the two groups using SPSS 17.0 statistical software in two groups of treatment improvement.ResultsThe total effective rate was 95.45%in the observation group and 72.73%in the control group,the difference was statistically significant(P＜0.05).The two groups had lower swallowing function scores after treatment,but this score in the observation group was obviously decreased (P＜0.05).ConclusionThe effect of early swallowing function training is significant,which is beneficial to the recovery of swallowing function in stroke patients with swallowing disorder,it is worthy of further promotion.
2017 Vol. 24 (29): 191-193 [
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167
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72
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Influence of early nursing intervention on the incidence of complications of arteriovenous fistula in maintenance hemodialysis patients
ZHANG Xia
ObjectiveTo explore the influence of early nursing intervention on the incidence of complications of arteriovenous fistula in maintenance hemodialysis patients.MethodsClinical data of 140 cases with maintenance hemodialysis treated in our hospital from January 2015 to January 2017 were selected and they were randomly divided into control group and experimental group,the control group
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the routine therapy and nursing,the experimental group received early nursing intervention.The incidence of complications and long－term quality of life were compared between the two groups.ResultsThe incidence of complication rate of the experimental group was 11.43%,and that of the control group was 54.29%.The complication rate of the experimental group was lower than that of the control group,and the difference was statistically significant (P ＜0.05).The various long－term quality of life indicators of the maintenance hemodialysis in the experimental group were higher than those in the control group,and the difference was statistically significant(P＜0.05).ConclusionEarly nursing intervention for hemodialysis patients is helpful to reduce the incidence of complications of arteriovenous fistula and improve the quality of life in the long run.
2017 Vol. 24 (29): 194-196 [
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153
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