脑梗死合并睡眠呼吸暂停患者通气功能与血脂代谢、胰岛素抵抗及动脉粥样硬化程度的相关性

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Abstract

ObjectiveTo investigate the correlation etween ventilation function and blood lipid metabolism,insulin resistance,atherosclerosis degree in patients with cerebral infarction complicated with sleep apnea.Methods32 patients with cerebral infarction complicated with sleep apnea treated in our hospital from September 2014 to December 2016 were collected as group A,43 patients with simple cerebral infarction were selected as group B,and 50 healthy subjects who received：physical examination in our hospital during the same period were collected as normal control group.Ventilation function index,blood lipid metabolism index and insulin resistance index and ultrasonic atherosclerosis parameter of three groups were determined.Pearson method was used to assess the correlation between ventilation function and blood lipid metabolism,insulin resistance and atherosclerosis parameter in patients with cerebral infarction complicated by sleep apnea.ResultsVentilation function indexes FEV1and FEV1/FVC level of group A and group B were lower than those of normal control group(P＜0.05),blood lipid metabolism indexes such as TC,TG and LDL－C content in peripheral blood were higher than those of normal control group (P＜0.05),while HDL－C content were lower than those of normal control group(P＜0.05).FINS and HOMA－IR level in peripheral blood were higher than those of normal control group(P＜0.05).Ultrasonic atherosclerosis parameter such as IMT,AC and PWVβ level were higher than those in normal control group,and the above changes in group A were greater than those in group B (P＜0.05).Pearson test showed that the ventilation function level in patients with cerebral infarction complicated by sleep apnea were directly correlated with the blood lipid metabolism,insulin resistance and atherosclerosis severity.ConclusionThere are ventilation function inhibition in patients with cerebral infarction complicated by sleep apnea,and the specific state of ventilation is directly correlated with disease severity indicators such as blood lipid metabolism,insulin resistance,atherosclerosis and so on.

Key words： Cerebral infarction Sleep apnea Ventilation function Lipid metabolism Insulin resistance

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LU Feng-cai. Correlation between ventilation function and blood lipid metabolism,insulin resistance,atherosclerosis degree in patients with cerebral infarction complicated with sleep apnea[J]. 中国当代医药, 2017, 24(29): 36-39.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I29/36

[1]	张馨，赵雅宁.阻塞性睡眠呼吸暂停低通气综合征合并脑梗死患者认知功能障碍相关危险因素的研究[J].中华老年心脑血管病杂志，2017，19（2）：167－170.
[2]	王驰仲.阻塞性睡眠呼吸暂停低通气综合征与脑梗死的关系[J].齐齐哈尔医学院学报，2017，38（2）：164-167.
[3]	Zhang W，Zhao ZR，Dai CF，et al.Correlation between Calpain-10 single-nucleotide polymorphisms and obstructive sleep apnea/hypopnoea syndrome with ischemic stroke in a Chinese population：a population-based study[J].Medicine（Baltimore），2017，96（16）： e6570.
[4]	贾惠，杨波，刘禹，等.哮喘和慢性阻塞性肺疾病患者呼吸阻抗与通气功能相关性分析[J].现代生物医学进展，2016，16（34）：6669-6672.
[5]	Nava-Guerra L，Tran WH，Chalacheva P，et al.Model-based stability assessment of ventilatory control in overweight adolescents with obstructivesleep apnea during NREM sleep[J].J Appl Physiol（1985），2016，121（1）： 185-197.
[6]	刘江伟，赵立，朱丽华，等.气流受限不完全可逆的慢性阻塞性肺疾病患者容量和流速变化与肺通气功能障碍严重程度分级的关系[J].中国医科大学学报，2016，45（9）：805-808.
[7]	Burschtin O，Wang J.Testosterone deficiency and sleep apnea[J].Sleep Med Clin，2016，11（4）：525-529.
[9]	郭东青.血塞通联合西医抗血小板治疗脑梗死患者的疗效及对血脂代谢的影响[J].中国实用神经疾病杂志，2016，19（19）：84-88.
[13]	顾成武，郭伟鹏，蒋世杰，等.脑梗死患者胰岛素抵抗与血浆同型半胱氨酸水平的相关性分析[J].华西医学，2016，31（1）：7-10.
[15]	黄辉，朱正球，栾云，等.超极速超声成像脉搏波技术在早期颈动脉粥样硬化风险动态评估中的应用价值[J].东南大学学报（医学版），2017，36（1）：9-12.
[16]	郭萌，杨青，李蔚，等.冠心病患者颈动脉粥样硬化的超声特征及其与病情严重程度的相关性[J].海南医学院学报，2017，23（3）：316-320.
[8]	Draganova AI，Terziyski KV，Kostianev SS.Identifying predictors of central sleep apnea/cheyne-stokes breathing in chronic heart failure：a pathophysiological approach[J].Folia Med （Plovdiv），2016，58（4）：225-233.
[10]	Zhang L，Song K，Zhu M，et al.Proprotein convertase subtilisin/kexin type 9 （PCSK9） in lipid metabolism，atherosclerosis and ischemic stroke[J].Int J Neurosci，2016，126（8）：675-680.
[11]	Mehra R，Bena J，Walia HK.Clarifying the role of hypoxia in obstructive sleep apnea as a potential promulgator of atrial fibrillation in ischemic stroke[J].J Clin Sleep Med，2017，13（5）：667-668.
[12]	Swartz RH，Cayley ML，Lanctot KL，et al.The"DOC"screen：feasible and valid screening for depression，obstructive sleep apnea（OSA）and cognitive impairment in stroke prevention clinics[J].PLoS One，2017，12（4）： e0174451.
[14]	Katsiki N，Mikhailidis DP.Pioglitazone in patients with insulin resistance after ischemic stroke or transient ischemic attack：a comment on the IRIS trial[J].J Diabetes Complications，2017，31（1）：1-3.