四逆汤联合单硝酸异山梨酯治疗变异性心绞痛的效果分析

Abstract
Figure/Table
References (20)
Related Citation (12)

Download: PDF (0 KB) HTML (35 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo study the efficacy of Sini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris.Methods74 patients with variant angina pectoris in the Central Hospital of Zibo Mining Group Co.,LTD.from June 2014 to April 2017 were selected and divided into the combination group and the control group by random number table method,37 cases in each group.The combination group was treated with Sini Decoction combined with Isosorbide Mononitrate,the control group was treated with Isosorbide Mononitrate.During the course of treatment,the frequency and duration of angina pectoris in the two groups were observed.2 weeks after treatment,cardiac function indexes and serum cytokines were determined in the two groups.ResultsThe frequency of angina pectoris in the combined group was significantly less than that in the control group and the duration of each attack in the combined group was significantly shorter than that in the control group,with significant difference (P＜0.05).After 2 weeks of treatment,cardiac function indexes CO,EF of the combination group was significantly higher than that of the control group,with significant difference(P＜0.05);serum tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),intercellular adhesion molecule-1(ICAM-1)contents in the combination group was significantly lower than that in the control group,with significant difference(P＜0.05).ConclusionSini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris can reduce angina pectoris,improve heart function and inhibit inflammatory reaction.

Key words： Sini Decoction Variant angina pectoris Heart function Inflammatory reaction Cytokine

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TAN Ming-qin

Cite this article:

TAN Ming-qin. Effect analysis of Sini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris[J]. 中国当代医药, 2017, 24(29): 121-123.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I29/121

[1]	Kim HL，Lee SH，Kim J，et al.Incidence and risk factors associated with hospitalization for variant angina in Korea[J].Medicine （Baltimore），2016，95（13）：e3237
[2]	Zhang S，Yan H，Yu P，et al.Development of protocatechualdehyde proliposomes-based sustained-release pellets with improved bioavailability and desired pharmacokinetic behavior for angina chronotherapy[J].Eur J Pharm Sci，2016，10（93）：341-350.
[3]	武艳玲，张奇，杨琴，等.变异型心绞痛临床治疗一例[J].江苏实用心电学杂志，2016，25（4）：257-260.
[4]	杨琴，张奇，王安才，等.变异型心绞痛的心电图特征[J].实用心电学杂志，2016，25（4）：251-256.
[5]	杨桂英，刘筱菲.平板运动试验诱发变异性心绞痛一例[J].江苏实用心电学杂志，2015，24（5）：378-380.
[6]	Akyildiz ZI.Poor tolerance and limited effects of isosorbide-5-mononitrate in microvascular angina[J].Cardiology，2015，130（4）：221-222.
[7]	Wu M，Villano A，Russo G，et al.Poor tolerance and limited effects of isosorbide-5-mononitrate in microvascular angina[J].Cardiology，2015，130（4）：201-206.
[8]	徐丽，朱庆贵.四逆汤结合地尔硫卓治疗变异型心绞痛临床疗效[J].陕西中医，2017，38（1）：14-15.
[9]	黄贝莉.四逆汤在冠心病心绞痛患者中的应用观察[J].海峡药学，2016，28（9）：118-119.
[10]	Mygind ND，Michelsen MM，Pena A，et al.Coronary microvascular function and cardiovascular risk factors in women with angina pectorisand no obstructive coronary artery disease：the iPOWER study[J].J Am Heart Assoc，2016，5（3）：e003064.
[11]	Slavich M，Maranta F，Fumero A，et al.Long-term preservation of left ventricular systolic function in patients with refractory angina pectoris and inducible my ocardial ischemia on optimal medical therapy[J].Am J Cardiol，2016，117（10）：1558-1561.
[12]	Horváth Z，Csuka D，Vargova K，et al.Alternative complement pathway activation during invasive coronary procedures in acute myocardial infarction and stable angina pectoris[J].Clin Chim Acta，2016，463：138-144.
[13]	Mostowik M，Siniarski A，Golebiowska-Wiatrak R，et al.Prolonged CRP increase after percutaneous coronary intervention is associated with high thrombin concentrations and low platelet′response to clopidogrel in patients with stable angina[J].Adv Clin Exp Med，2015，24（6）：979-985.
[14]	Gin AL，Vergallo R，Minami Y，et al.Changes in coronary plaque morphology in patients with acute coronary syndrome versus stable angina pectoris after initiation of statin therapy[J].Coron Artery Dis，2016，27（8）：629-635.
[15]	Neufcourt L，Assmann KE，Fezeu LK，et al.Prospective association between the dietary inflammatory index and cardiovascular diseases in the supplémentation en vitamines et minéraux antioxydants （SU.VI.MAX） cohort[J].J Am Heart Assoc，2016，5（3）：e002735.
[16]	Wu JJ，Guérin A，Sundaram M，et al.Cardiovascular event risk assessment in psoriasis patients treated with tumor necrosis factor-α inhibitors versus methotrexate[J].J Am Acad Dermatol，2017，76（1）：81-90.
[17]	Dopheide JF，Knopf P，Zeller GC，et al.Low IL-10/TNFα ratio in patients with coronary artery disease and reduced left ventricular ejection fraction with a poor prognosis after 10 years[J].Inflammation，2015，38（2）：911-922.
[18]	Caselli C，De Graaf MA，Lorenzoni V，et al.HDL cholesterol，leptin and interleukin-6 predict high risk coronary anatomy assessed by CT angiography in patients with stable chest pain[J].Atherosclerosis，2015，241（1）：55-61.
[19]	Tang JN，Shen DL，Liu CL，et al.Plasma levels of C1q/TNF-related protein 1 and interleukin 6 in patients with acute coronary syndrome or stable angina pectoris[J].Am J Med Sci，2015，349（2）：130-136.
[20]	Jalaly L，Sharifi G，Faramarzi M，et al.Comparison of the effects of Crataegus oxyacantha extract，aerobic exercise and their combination on the serum levels of ICAM-1 and E-selectin in patients with stable angina pectoris[J].Daru，2015，23：54.