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| The progress of the NF-κB signaling pathway regulated by miRNA-16 |
| LIU Chao CHEN Han-juan |
| Department of Medical Laboratory and Pharmacy,Jiangsu College of Nursing,Jiangsu Province,Huaian 223305,China |
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Abstract The miRNA-16,gene of coding which is located on chromosome 13,belong to the non-coding RNA and consists of 22 nucleotides,which could regulate the expression of NF-κB.NF-κB is a multidirectional adjustment of transcription factors,such as NF-κB couldn adjust the protein Bcl-x expression and other anti-apoptotic proteins exprsssion when also could adjust the protein IL-2 expression and other growth factors expression,also could adjust the gene-TRAF1 expression and other anti-apoptotic gene expression.Therefore,NF-κB is closely related to tumor proliferation and apoptosis.MiRNA-16 may be combined with promoter region or 3′UTR of the NF-κB,and could indirectly regulate anti-apoptotic genes,anti-apoptotic proteins and growth factors by NF-κB.The synthesis and function of mirna-16 and NF-κB were reviewed in this paper,and the potential anti-apoptotic gene,anti-apoptotic protein,growth factor and other control targets of mirna-16 were reviewed.
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