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2018 Vol. 25, No. 12
Published: 2018-04-28
4
Study on genome editing targeting CCL17 and CCL22 using CRISPRCas9 system
GAO Shu-hui;QU Chuang;WU Feng-lin;SHEN Han
Objective
To design CRISPR/Cas9-gRNA targeting human CCL17 and CCL22 gene,and to evaluate the editing effectiveness of the sgRNA.
Methods
The targeted editing sites of CCL17 and CCL22 genes were screened using tools provided by CRISPR website,then the knockout plasmid of CRISPR-Cas9-CCL17 and CRISPR-Cas9-CCL22 were constructed and separately transfected into 293 T cells.Finally,the T-A editing and sequencing methods of genomic PCR products were used to verify the editing efficiency of the designed sgRNA knockout plasmid.
Results
The knockout plasmid of CRISPR-sgRNA targeting human CCL17 and CCL22 gene was successfully constructed with high editing efficiency,reached more than 70%.
Conclusion
The CRISPR-Cas9-CCL17 and CRISPR-Cas9-CCL22 show good editing efficiency,which provide foundation for the deep research of the function on CCL17 and CCL22.
2018 Vol. 25 (12): 4-8 [
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169
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9
The relationship of myocardial apoptosis and endoplasmic reticulum stressrelated protein CHOP in swine following coronary microembolization
LIN Chong-qiang;LIU Tao;TANG Zhong-li;LIU Yang-chun;LI Lang
Objective
To investigate the relation of myocardial apoptosis and endoplasmic reticulum stress-related(CME)protein C/EBP homologous protein (CHOP)in swine following coronary microembolization.
Methods
Fifty swine were selected and randomly divided into the Sham group (n=25)and the CME group (n=25).Five subgroups were assigned according to time points(3,6,12,24,48 h),5 cases in each group.The CME model was established through injecting microspheres into the coronary artery,while swine in the Sham group received the same dose of normal saline instead.Cardiac function was measured with echocardiography.Histopathological changes were detected with HE.Microinfarction and apoptotic index were detected with hematoxylinbasic fuchsinpicric acid (HBFP)and TUNEL stainings,respectively.The expressions of CHOP and Caspase-3 proteins were determined with Western blot.
Results
Compared with the Sham groups,the cardiac function was decreased in varying degrees in the corresponding CME groups(P＜0.05).The cardiac function of 12 h following CME was the worst.Microinfarction rather than massive necrosis was found each time points following CME,mainly located in left ventricle and subendocardial myocardium.The difference,however,was not statistically significant(P＞0.05).Compared with the Sham groups,the apoptotic index in the corresponding CME groups were increased in varying degrees(P＜0.05).It peaked 12 h following CME.Apoptotic cardiomyocytes were mainly located in microinfarct area and its border area.Compared with the Sham groups,CHOP protein expression in the corresponding groups following CME enhanced in varying degrees(P＜0.05),showing dynamic changes.It peaked 12 h following CME.
Conclusion
CME induces cardiomyocyte apoptosis and cardiac dysfunction,in which enhanced CHOP and caspase-3 expression may be involved.
2018 Vol. 25 (12): 9-13 [
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192
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14
Determination of the content of cardiac glycoside in Zhuang herb Streptocaulon griffithii and its influencing factors of different producing areas and harvesting seasons
LUO Yu-dong;TAN An-qiang; LU Shi-heng;WU Yu-qiang;ZHANG Qiang
Objective
To establish a method for the determination of cardiac glycoside in Zhuang herb Streptocaulon griffithii,and to study the influence of different producing areas and harvesting seasons on the content of medicinal herb.
Methods
The colorimetric reaction of α,β -unsaturated lactone ring of type A cardiac glycosides was used to establish the method for the determination of the content of cardiac glycoside in Streptocaulon griffithii by ultraviolet spectrophotometry (UV spectrophotometry).The methodology was also verified.The content of cardiac glycoside in Zhuang herb Streptocaulon griffithii from different producing areas and harvesting seasons was determined.
Results
By UV spectrophotometry,Digoxin was used as reference substance,and alkaline picric acid solution was used as chromogenic agent.The good linear relation of the content of reference substance and absorbance was displayed in the range of 0-0.08 mg/ml in 415 nm wavelength.The regression equation y=14.968x+0.008 (r=0.9969).The precision of RSD was 0.1%and average recovery was 95.51%(n=6;RSD=2.16%).The average content of cardiac glycosides from 6 batches of Streptocaulon griffithii was 2.07 mg/g.The cardiac glycosides of Streptocaulon griffithii from four different producing areas and seasons in the Guangxi Zhuang Autonomous Region were determined.The highest content of cardiac glycoside of Streptocaulon griffithii was from Basaigou,Qinzhou City and was collected from October to December yearly.
Conclusion
The established method for the determination of cardiac glycosides of Streptocaulon griffithii has high stability and repeatability in good recovery,and can be used as quality control for Streptocaulon griffithii.Differentproducing areasand harvesting seasons have significant impact on the content of cardiac glycosides of Streptocaulon griffithii.
2018 Vol. 25 (12): 14-17 [
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176
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18
Effect of intracoronary injection of Tirofiban on emergency percutaneous coronary intervention in patients with acute myocardial infarction
ZHANG Wei;XUE Zhong-wen
Objective
To investigate the clinical effect of intracoronary injection of Tirofibanon on emergency percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).
Methods
From January 2015 to January 2017,120 patients with AMI were selected and divided into the control group and the observation group according to the random number table method,60 cases in each group.The control group was treated with routine drugs and PCI.In the observation group,10 μg/kg Tirofiban injection was administered at the same time of routine medication and PCI,and the vein was maintained at 0.15 μg/(kg·min)after operation.The changes of blood flow classification and CTFC values in the two groups of patients with myocardial infarction thrombolytic test(TIMI)before and after treatment were compared.Left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular endsystolic diameter(LVESD)and plasma BNP concentration were compared between the two groups.
Results
Before treatment,there was no significant difference in the proportion of patients with TIMI grade 3 and CTFC between the two groups (P＞0.05).After treatment,the proportion of patients with TIMI grade 3 or above in the observation group was higher than that in the control group,but the CTFC was lower than that in the control group (P＜0.05).The LVEF at 3,15,30 d after operation in the observation group was higher than that of the control group,while the LVEDD and LVESD were lower than the control group,and the differences were statistically significant(P＜0.05).The plasma BNP concentration in the observation group was significantly lower than that in the control group(P＜0.05).
Conclusion
Coronary artery injection of Tirofibanon can significantly improve heart function in patients with AMI,the effect is significant and safe,it is worth to be widely used in clinical practice.
2018 Vol. 25 (12): 18-20转24 [
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21
Diagnostic value of MRI examination on cartilage injury of patellofemoral arthritis
ZHAI Jian-chun;SHI An-bin;ZHANG Liang-jin;FANG Wen-liang;ZHANG Wen-jun;WU Ji-xiong
Objective
To explore the diagnostic value of MRI examination on cartilage injury of patellofemoral arthritis.
Methods
From March 2015 to September 2017,the MRI imaging data of 67 cases of patellofemoral arthritis who hospitalized in the department of orthopedics in our hospital were analyzed,retrospectively.The MRI examination included the FS-FSE-T2W sequence and the 3D-FS-SPGR sequence.The MRI examination results was compared with the results of arthroscopy.
Results
Among the 67 patients,36 cases were cartilage injury in the medial margin of the patella,31 cases were cartilage injury in the anterolateral border of the lateral condyle of the femur.MRI examination showed that 27 cases were abnormal cartilage and signal in the medial margin of the patella,21 cases showed abnormal cartilage injury in the anterolateral border of the lateral condyle of the femur,6 cases showed thinning of cartilage,and 13 cases showed significant interruption or defect of local cartilage.The sensitivity and specificity of FS-FSE-T2W sequence for cartilage injury were 83.65%and 96.27%,respectively,and the sensitivity and specificity of 3D-FS-SPGR sequence were 93.67%and 99.18%,respectively,the differences were statistically significant(P＜0.05).
Conclusion
MRI examination can accurately and objectively identify the location,extent and extent of cartilage injury of patellofemoral arthritis,and the 3DFS-SPGR sequence is a little better than that in the FS-FSE-T2W sequence in evaluating the accuracy of the patellar osteoarthritis cartilage injury.
2018 Vol. 25 (12): 21-24 [
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160
)
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25
Effect of TGFβ
1
/BMP on pulmonary arterial hypertension induced by vascular smooth muscle cell proliferation
1/BMP on pulmonary arterial hypertension induced by vascular smooth muscle cell proliferation[J]. 中国当代医药, 2018,25(12): 25-28')" href="#">
ZHAO Dan-rui;REN Zhou-xin; LI Jian-sheng
Pulmonary arterial hypertension (PAH)is a pulmonary vascular devastating disease.It has the characteristics of fatality and poor prognosis,and it is currently not completely curable.The main pathogenic factors of this disease are the thickening of the pulmonary vascular smooth muscle medium and the invasive proliferation of smooth muscle cells into the intima.This abnormal proliferation leads to vascular hypertrophy,pulmonary vascular resistance and pulmonary arterial pressure continue to rise.And TGFβ
1
/BMP signaling is an important signal transduction pathways regulating pulmonary arterial remodeling of pulmonary hypertension,which involved a number of key targets in drug research,clinical treatment and pathological mechanisms study.This review summarizes the effects of TGFβ
1
/BMP signaling pathway on PAH and its mechanism of the vascular smooth muscle cell proliferation.
2018 Vol. 25 (12): 25-28 [
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158
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Progress autophagy mechanism and autophagy-related signaling pathways after cerebral ischemia-reperfusion injury
LI Yan-ze;GUO Yong-qing; WEI Jian-feng;ZHENG Li-na
Autophagy is a highly conserved material decomposition and metabolism pathway in the evolution of eukaryotes,which allows the orderly degradation and recycling of intracellular damaged organelles or misfolded long-acting macromolecule.But hyperactivation of autophagy is an injury mechanism for the body.The injury mechanism of cerebral ischemia reperfusion injury is not only related to various pathophysiological processes,but also plays an important role in autophagy.Since autophagy has gradually become a target for the prevention and treatment of a variety of major diseases in human beings,its mechanisms arose increasing attention.This paper aims to summarize the related concepts about autophagy,study the relationship between autophagy and cerebral ischemia reperfusion injury as well as introduce the signaling pathways involved in autophagy.
2018 Vol. 25 (12): 29-32 [
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151
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33
Effect of bed rehabilitation exercise in the prevention of deep venous thrombosis in patients with femoral fracture after operation
LIANG Fei-yan; RAO Jing-yun; FENG Xiu-ping; ZOU Jing-yi; DENG Shun-hua;ZHANG Dai-xiong;YAN Shao-mei;LIANG Si-min
Objective
To investigate the bed rehabilitation exercise in postoperative patients with femoral fracture prevention application of deep venous thrombosis.
Methods
From January 2017 to January 2018,120 cases of unilateral closedfemoralfracture patients were selected as the research objects treated in our hospital,the simple random differentiation were divided into two groups,60 cases in each group.The control group of orthopedic patients were received routine nursing care,the observation group patients on the basis of routine nursing care were accepted bed rehabilitation training.The incidence of deep venous thrombosis,recovery of limb function and satisfaction were compared between the two groups.
Results
In the observation group,2 patients had deep vein thrombosis (Deep Vein Thrombosis DVT),the incidence rate was 3.33%.In the control group,8 patients had DVT and the incidence was 13.33%.Compared with the two groups,the incidence of DVT in the observation group was significantly lower(P<0.05).Before nursing,observation group and control group,the motor function scores were(51.5±11.1),(52.3±12.0)point,the difference was not statistically significant(P＞0.05);after nursing care,observation group and control group,the motor function scores were(83.2±10.4),(62.0±13.5)point,the two group and the nursing before the deal was increased compared (P<0.05),and the observation group was significantly higher than that of control group(P<0.05).The satisfaction rate of the patients in the observation group was significantly higher than that of the control group,the differences were statistically significant(P<0.05).
Conclusion
In the nursing care of patients with femoral fracture after operation,the implementation of bed rehabilitation,can greatly reduce the incidence of DVT and promote the limb function rehabilitation,improve patient satisfaction,worthy of promotion.
2018 Vol. 25 (12): 33-35 [
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36
Clinical efficacy of laparoscopy in the treatment of acute appendicitis
LIN Jun-shuang
Objective
To explore the clinical effect of laparoscopy in the treatment of acute appendicitis.
Methods
A total of 40 patients with acute appendicitis in our hospital from June 2015 to December 2017 were enrolled.They were evenly and randomly divided into two groups by the envelope method,20 cases in each group.In the control group,surgery with a small incision was used,while in the observation group,laparoscopic surgery was adopted.
Results
The operative time,intestinal function recovery time,postoperative bed-out time,hospital stay,antibiotic use time and incision length in the observation group were all shorter than those of the control group(P<0.05).The intraoperative blood loss was lesser than that of the control group(P<0.05).The pain scores 12,24,and 48 hour after surgery were lower than those in the control group (P<0.05).The incidence of complications was also lower than that in the control group,the differences were statistically significant(P<0.05).
Conclusion
Laparoscopic surgery for patients with acute appendicitis is effective in high safety.
2018 Vol. 25 (12): 36-38 [
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144
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39
Influence of rehabilitation interventional treatment at different stages on functional recovery in elderly patients with cerebral hemorrhage
LU Shao-huan;CHENG Wan-chun;HUANG Lin
Objective
To explore the effect of rehabilitation intervention at different stages on the functional recovery in elderly patients with cerebral hemorrhage.
Methods
From July 2014 to July 2017,160 patients with senile cerebral hemorrhage in our hospital were selected and grouped by lottery,80 patients in each group.The control group was treated with advanced rehabilitation and the observation group was treated with early rehabilitation as interventions respectively.The upper limb scores,lower limb scores,neurological deficit scores,and MBI scores were compared in the two groups.
Results
1,3,and 6 weeks after treatment,the MBI scores in the observation group were(78.95±2.68),(85.94±2.65)and(96.38±1.58)points,and the upper and lower limb scores were(32.86±5.41)and(18.96±3.21)points respectively,all higher than the corresponding indices in the control group of(72.36±1.32),(80.15±1.33),(86.98±1.11)points,(28.41±3.69),and(22.87±5.42)points.The differences were statistically significant(P<0.05).The neurological defect scores in the observation group were (16.58±1.33),(13.28±1.42)points,and (8.63±1.03)points,which were lower than those in the control group of(18.96±1.45),(16.37±1.54)points and(11.39±1.42)points with significant differences(P<0.05).
Conclusion
Early rehabilitation interventional therapy for elderly patients with cerebral hemorrhage can promote functional recovery.
2018 Vol. 25 (12): 39-41 [
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154
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42
Effect of aerobic rehabilitation combined with psychological rehabilitation therapy in perioperative patients with breast cancer
GUAN Xiao-ning
Objective
To investigate the application of aerobic rehabilitation combined with psychological rehabilitation therapy in patients with perioperative breast cancer.
Methods
A total of 140 patients with perioperative breast cancer hospitalized in our hospital from January to September 2017 were selected.They were divided into control group(70 cases)and rehabilitation group (70 cases)according to random number table method.The conventional treatment of symptomatic postoperative radiotherapy and chemotherapy for breast cancer patients in both groups was performed.The control group patients were received basic cognitive education and voluntary exercise training on the basis of routine treatment.The rehabilitation group patients were received aerobic rehabilitation exercise combination of psychological rehabilitation therapy on the basic of routine treatment,aerobic rehabilitation exercise including qigong and dance practice,psychological rehabilitation therapy,including improving cognition,listening to music,relaxation of ideas and so on.Two groups of patients were treated for two weeks of continuous treatment.The differences between the two groups in the comprehensive physical condition,depression,QLQ-C30 score and inflammatory factors were compared and analyzed.
Results
After intervention,the two groups of patients had significantly improved physical quality,depression,QLQC30 score,and the degree of improvement in the rehabilitation group were more significant than those in the control group(P<0.05).
Conclusion
Aerobic rehabilitation combined with psychological rehabilitation therapy can reduce the pain and promote the recovery of patients with breast cancer during perioperative period.
2018 Vol. 25 (12): 42-44 [
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174
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45
Clinical analysis of rahrhubarb combined with light liquid paraffin in the treatment of acute pancreatitis
HU Hua-bin;GUO Yan-xiong
Objective
To observe the clinical effect of rawrhubarb combined with light liquid paraffin in treatment of acute pancreatitis(AP).
Methods
A total of 94 patients with AP in emergency department from January 2014 to August 2016 in our hospital were randomly divided into control group and treatment group,46 cases in each group.Control group patients were given standrad treatment,the treatment group was treated with 100 ml raw rhubarb fluid combined with light liquid paraffin by gastric tube on the basis of standard treatment.The anal exhaust time,remission time of abdominal pain,the first laxative time and recovered time of CRP and blood amylase between the two groups were compared,at the same time,the differences of APACHE-Ⅱscore,Balthazar CT score before and after treatment were observed.
Results
Anal exhaust time,remission time of abdominal pain,the first laxative time were significantly shorter than those in the control group,recovered time of CRP and blood amylase in the treatment group were also significantly shorter than that in the control group.The differences were statistically significant(P<0.05).Compared with the control group,the APACHE-Ⅱscore had significant difference (P<0.05),but Balthazar CT score had no significant difference(P＞0.05).
Conclusion
Therapy of raw rhubarb combined with light liquid paraffin in acute pancreatitis patients can significantly reduce the anal exhaust time,remission time of abdominal pain,the first laxative time,recovery time of blood amylase and CRP,the APACHE-Ⅱscore,too.
2018 Vol. 25 (12): 45-47 [
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48
Experience of laparoscopic diagnosis and treatment of Mirizzi syndrome in 37 cases
LI Shu-jie;GONG Zi-qi;WANG Yan;SUN Kai;XU Cai-teng
Objective
To explore the diagnosis of Mirizzi syndrome and the treatment by laparoscopic surgery.
Methods
The clinical data of Mirizzi syndrome patients who were diagnosed before or during the surgery from January 2002 to December 2016 in our hospital were retrospectively analyzed.
Results
A total of 37 patients with Mirizzi syndrome were enrolled including typeⅠ(n=28),typeⅡ(n=8),and typeⅢ(n=1).No typeⅣcase was involved in this study.Among typeⅠ,18 patients were performed with laparoscopic cholecystectomy,7 with laparoscopic sub-total cholecystectomy,and the rest 3 patients were converted to laparotomy due to severe adhesion or biliary injury.Among typeⅡ,5 patients were performed with laparoscopic sub-total cholecystectomy+fistula repair,1 with the combination of laparoscopic choledocholithotomy+sub-total cholecystectomy+fistula repair+T tube drainage(T tube across the fistula site),and the remaining 2 were converted to laparotomy due to common hepatic duct injury.Among typeⅢ,the patient was converted to cholecystojejunostomy (Roux-en-Y)by laparotomy due to large common hepatic duct fistula.
Conclusion
For patients with suspected Mirizzi syndrome,preoperative examination should be performed to confirm the diagnosis.Laparoscopic surgery is safe and feasible for typeⅠ and partial typeⅡ patients,but for patients with typeⅡin severe local adhesion or large fistula,Ⅲand Ⅳ,laparotomy is an optimal choice.
2018 Vol. 25 (12): 48-50 [
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51
Study of the risk factors related to permanent atrial fibrillation
ZHOU Huang;YIN Yue-hui
Objective
To explore the risk factors related to permanent atrial fibrillation(AF)and discuss the clinical significance.
Methods
A total of 169 inpatients of our department with atrial fibrillation (AF)from January 2015 to March 2017 were consecutively enrolled in this study.They were divided into paroxysmal AF group (n=53)and permanent AF group(n=116)by the consensus of WGA-ESC and NASPE.The clinical data and the results of laboratory tests and ultrasound cardiograms were collected,risk factors of AF were analyzed by logistic regression analysis.
Results
There were no significant differences in gender,age,smoking,drinking,hypertension,diabetes or coronary heart disease between the two groups(P＞0.05).However,the levels of SUA (324.1±86.1 vs.377.9±96.9,P<0.001),pro-BNP(175.3[99.0,529.7]vs.1084.0[750.4,2238.3],P<0.001)and LAD(35.8±5.0 vs.41.9±5.0,P<0.001)were higher in permanent AF group rather than in paroxysmal group.The stepwise regression analysis results were showed,SUA (OR=1.005 [1.001-1.010],P=0.027),pro-BNP(OR=1.329[1.000-1.001],P=0.026)and LAD(OR=1.329[1.199-1.475],P=0.001)levels were the risk factors of the development of permanent AF.
Conclusion
The SVA,pro-BNP and LAD may bethe risk factors of the development of permanent AF.
2018 Vol. 25 (12): 51-53转57 [
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The effect of slowly increasing blood flow rate treatment on intradialytic hypotension
ZHOU Yang;YE Fan; YIN Jin-feng
Objective
To explore the therapeutic effect of slowly increasing blood flow rate treatment on intradialytic hypotension.
Methods
A total of 19 patients who have frequent intradialytic hypotension during the treatment of maintenance hemodialysis in our hospital from January to October 2016,were selected,who were treated with slowly increasing blood flow rate hemodialysis.Each time the patient′s blood was extracted at the blood flow rate of 100 ml/min,then increased to 120 ml/min after 15 minutes,30 minutes later increased to 160 ml/min,increased to 180 ml/min after 45 minutes,60 minutes later increased to 200 ml/min,no longer increases.The hemodialysis mode was performed continuously for 12 weeks,3 times a week for 4 hours.The incidence of intradialytic hypotension,after treatment blood pressure,the lowest blood pressure in hemodialysis,hemodialysis time,ultrafiltration,hemoglobin,albumin and spKT/V were compared.
Results
The incidence of intradialytic hypotension after treatment was much lower than before treatment,with a statistical difference(P<0.05).The after treatment blood pressure,the lowest blood pressure in hemodialysis,hemodialysis time,ultrafiltration,hemoglobin,albumin and spKT/V were all increased,and the differences were statistically significant(P<0.05).
Conclusion
Slowly increasing blood flow rate treatment model can effectively reduce the incidence of intradialytic hypotension,improve hemodialysis sufficiency,and improve the nutritional status of patients.
2018 Vol. 25 (12): 54-57 [
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Effect of carbon dioxide pneumoperitoneum on neonatal brain function
LUO Chun-fang;NIU Li-wen
Objective
To analyze the effect of carbon dioxide pneumoperitoneum on neonatal brain tissue function and provide basis for the safe application of laparoscopy in neonatal treatment.
Methods
A total of 36 neonates undergoing laparoscopic surgery for duodenal ileus in our hospital from January 2016 to June 2017 were selected as laparoscopic group.During the same period,another group of 20 patients undergoing routine surgical treatment for duodenal obstruction were selected as control gorup.The brain function parameters of children in the laparoscopic group were determined 15 min before pneumoperitoneum(T
0
),15 min after pneumoperitoneum(T
1
),45 min after pneumoperitoneum(T
2
),and 15 min after the end of pneumoperitoneum(T
3
).The neonatal behavioral neurological assessment(NBNA)scores were compared between the two groups.
Results
The levels of serum neuron-specific enolase (NSE)and S100β protein at the T
1
and T
2
in the laparoscopic group were significantly higher than those at the T
0
(P<0.05).The concentrations of NSE and S100β protein at the T
3
were lower than those during the pneumoperitoneum,but still higher than those before pneumoperitoneum,which were displayed statistical differences(P<0.05).There was no significant difference in NBNA scores between the two groups(P＞0.05).
Conclusion
Artificial CO
2
pneumoperitoneum has reversible effect on serum levels of NSE and S100β in neonates,but no significant effect on neonatal neurological behavior.
2018 Vol. 25 (12): 58-60 [
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Application effect of Etomidate and Propofol anesthesia under Narcotrend monitoring maintaining laparoscopic surgery in elderly patients
CHEN Zhi;LUO Hai-dong;LIN Yue-hua;ZHANG Yue-nong
Objective
To investigate the application effect of Etomidate and Propofol anesthesia under Narcotrend monitoring maintaining the elderly patients undergoing laparoscopic surgeries.
Methods
A total of 100 elderly patients undergoing laparoscopic surgeries in our department from March 2016 to March 2017 were selected as the subjects.They were divided into two groups according to single or double month visit doctor.Both groups were provided with intravenous anesthesia maintaining by Etomidate and Propofol.In the control group,the infusion rate was adjusted based on symptoms and signs such as changes in blood pressure,heart rate(HR),and clinical experience,while in the research group,the infusion rate was changed based on Narcotrend monitoring.
Results
There was no difference in HR,mean arterial pressure (MAP)and anesthetic trend index between the two groups at the time of group entry and 5 s before induction of anesthesia(P＞0.05).In the research group,the indices of HR,MAP,and anesthetic trend index at intubation,5 minutes after intubation,eye-opening,extubation,and department leaving were all lower than those in the control group(P<0.05).The awake time,extubation time,and time of orientationrecoveryintheresearchgroupwereallshortercomparedwiththosein thecontrolgroup，thedifferenceswerestistically significant(P<0.05).No significant difference in the incidence of adverse reactions was displayed in the two groups (P＞0.05).
Conclusion
For elderly patients undergoing laparoscopic surgery,Etomidate and Propofol maintenance of anesthesia under Narcotrend monitoring can significantly reduce the indices of HR,MAP,and anesthetic trend index,shorten awake time,extubation time,and time of orientation recovery,and decrease the incidence of adverse reactions in high safety,which has an important clinical application value.
2018 Vol. 25 (12): 61-63 [
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Effects of Dexmedetomidine in different doses on sedation and analgesia in elderly patients with arthroplasty
ZHOU Wu-zhao;HU Qin-qing;LI Hong-qing
Objective
To compare the sedative and analgesic effects of Dexmedetomidine in different doses in elderly patients with arthroplasty.
Methods
A total of 84 elderly patients who underwent arthroplasty in our hospital from April to October in 2017 were divided into three groups according to the stratified randomized method.In combination group(n=28),low loading and maintenance doses of Dexmedetomidine was used.In maintenance group(n=28),a small dose of Dexmedetomidine for maintenance was selected.In the control group(n=28),intravenous infusion of saline was adopted.The sedative and analgesic effects among the three groups were compared.
Results
In both combination and maintenance groups,the sedation scores after medication and 30 min after medication were lower than those in the control group with statistical differences(P<0.05).In the combination group,the sedation scores after medication and 30 min after medication were lower than those after anesthesia,and the sedation score 30 min after treatment were lower than that just after medication(P<0.05).In the maintenance group,the sedation scores after medication and 30 min after treatment were both lower compared with those after anesthesia,which displayed statistical differences(P<0.05).In both combination and maintenance groups,the VAS analgesia scores after medication and 30 min after treatment were significantly lower than those in the control group(P<0.05).Meanwhile,they were all also lower than those after anesthesia(P<0.05).The scores of VAS analgesia 30 min after medication in the combination and maintenance group were lower than those just after medication(P<0.05).In the control group,the VAS analgesia score 30 min after medication was lower in comparison with that after anesthesia with a statistical difference (P<0.05).
Conclusion
Low-dose Dexmedetomidine in a continuous pump injection for sedation and analgesia in elderly patients with joint replacement can obtain a remarkable effect and is one of the appropriate surgical anesthesia methods.
2018 Vol. 25 (12): 64-66 [
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Effect of Ropivacaine on combined spinal-epidural anesthesia in cesarean section
LIAO Guo-qing
Objective
To analyze the effect of Ropivacaine on combined spinal-epidural anesthesia in cesarean section.
Methods
104 patients undergoing cesarean section under combined spinal-epidural anesthesia in our hospital from February to October 2017,were divided into Ropivacaine group(n=52)and Bupivacaine group(n=52)according to systic randomization.The Ropivacaine group was treated with 1.5 ml 0.5%Ropivacaine as the narcotic drug,and the Bupivacaine group was treated with the same dose and concentration of Bupivacaine.The nerve block time,anesthetic effect,hemodynamic difference at different times and abnormal reaction of the two groups were statistically analyzed.
Results
Starting time of sensory nerve and motor nerve block of the Ropivacaine group were later and duration were shorter than Bupivacaine group,the differences were statistically significant(P<0.05).The anesthesia effect of Ropivacaine was better than that of Bupivacaine(P<0.05).After 5 and 10 minutes of anaesthesia,the mean arterial pressure and systolic blood pressure of Ropivacaine group were higher than that of Bupivacaine group，the differences were statistically significant(P<0.05).There was no significant difference in the abnormal reaction between the two groups(P＞0.05).
Conclusion
Starting time of nerve block of using Ropivacaine is later and duration is shorter than Bupivacaine in cesarean section under combined spinal-epidural anesthesia.Ropivacaine is more effective than Bupivacaine.It has less influence on hemodynamics of puerpera.
2018 Vol. 25 (12): 67-69 [
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142
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Effect of Dexmetomidine combined with Propofol anesthesia on senile painless gastroscopy
LIAN Zhi-peng;ZHANG Quan
Objective
To compare the clinical effect of gastroscopy anesthesia in the elderly treated with Propofol combined with Dexmedetomidine.
Methods
A total of 88 elderly patients who received painless gastroscopy during the period from March 2016 to September 2017 were selected as observation subjects,and they were divided into control group(n=44)and observation group(n=44)according to the coin method.The control group patients were given Propofol anesthesia,the observation group patients were given Propofol combined Dexmetomidine on anesthesia,two groups of patients anesthesia induction time,recovery time,check the complications and adverse reactions after the test were compared.
Results
The observation group of patients anesthesia induction time,wake up of time was shorter than that in the control group patients,data respectively(133.8±19.4)s vs.(147.7±20.6)s,(95.2±16.2)s vs.(116.5±22.4)s,the two groups was statistically difference(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the data were 4.5%and 18.2%,respectively,and the comparison of the two groups was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 4.5%,compared with 11.4%in the control group,no statistical difference(P＞0.05).
Conclusion
The effect of Propofol combined with Dexmedetomidine in elderly patients with painless gastroscopy anesthesia is more significant,not only can shorten the induction time and recovery time of anesthesia,but also can reduce the occurrence of complications,with safe and reliable features,it is worth in the clinical further application and promotion.
2018 Vol. 25 (12): 70-72 [
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186
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73
Value analysis of three-dimensional color Doppler ultrasound combined with magnetic resonance imaging in the diagnosis of fetal central nervous system deformity
WANG Xian-jin
Objective
To investigate the value of three-dimensional color Doppler ultrasonography combined with magnetic resonance imaging （MRI） in the diagnosis of fetal central nervous system deformity.
Methods
From January 2016 to August 2017,30 pregnant women with prenatal examinations of fetal central nervous system deformity in our hospital were selected as research objects.All infants were confirmed by follow-up visits after childbirth or labor induction.Pregnant women were all examined by prenatal three-dimensional color Doppler ultrasound and MRI to analyze the combined diagnosis effect of the two methods.
Results
Three-dimensional color Doppler ultrasound and MRI were consistent with 12 cases accounting for 40.0%.There were 16 cases with supplementary diagnosis by MRI for 53.3%,and two cases with correct diagnosis which accounted for 6.7%.There was one case indicating abnormality by the detection of three-dimensional color Doppler ultrasound,but denied by MRI,accounting for 3.3%.The quality score of MRI image was superior to three-dimensional color Doppler ultrasound,with statistical significance （P＜0.05）.
Conclusion
In the diagnosis of fetal central nervous system deformity,the combined application of three-dimensional color Doppler ultrasound and MRI can obtain an optimal effect,which can complement and correct the diagnostic information each other,and deserves further study and promotion.
2018 Vol. 25 (12): 73-75 [
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178
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76
The value of ultrasound elasticity imaging combined with digital mammography in the differential diagnosis of breast tumor
LlANG Jin-hua;FENG Jian-ping;LIANG Jian-xiong;ZHOU Hong-hui;YI Jian-fen;ZHOU Zu-yong
Objective
To expore the application value of ultrasound elasticity imaging combined with digital mammography in the diagnosis of breast tumor,and to provide reference for clinical treatment.
Methods
The clinical data of 100 patients with breast tumor admitted to our hospital from February 2015 to March 2017 were analyzed retrospectively.All patients with breast masses were confirmed by pathological examination.Ultrasound elastography and mammography were performed on the masses and compared with postoperative pathological results.The diagnostic accuracy of the two methods and the combined diagnostic accuracy were compared and analyzed.
Results
There was no significant difference between ultrasonic elastography and molybdenum target photography in the coincidence rate between ultrasonic elastography and molybdenum target photography(P＞0.05).The coincidence rate between ultrasonic elastography and molybdenum target photography was significantly higher than that between ultrasonic elastography and molybdenum target photography,and the differences were statistically significant(P＜0.05).There was no significant difference in the results between ultrasound elastography and mammography(P＞0.05).Comparison of diagnostic sensitivity,specificity and ultrasonic elastography with molybdenum target photography,The difference was not statistically significant(P＞0.05),But there is an increasing trend.The accuracy of combined diagnosis was significantly higher than that of ultrasound elastography and mammography,and the differences were statistically significant(P＜0.05).
Conclusion
The diagnosis of ultrasound elasticity imaging combined with mammography is better than that of single diagnosis.It can be used widely in clinical application.
2018 Vol. 25 (12): 76-78 [
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164
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79
Application value of filling method in multi-slice spiral CT in the diagnosis of intestinal inflammatory bowel disease
HE Ya-lin;ZHOU Gang;LIU Qi-qiu;YU Hai-yi;LI Cai-yan;LI Jian-hui;LI Jing-min
Objective
To explore the clinical value of filling method in multi-slice spiral computed tomography （CT）examination of intestinal inflammatory bowel disease.
Methods
Sixty patients with inflammatory bowel disease admitted to our hospital from January 2016 to December 2017 were randomly divided into control group and observation group with 30 cases in each group.The observation group was examined by filling method with multi-slice spiral CT,while the control group was examined by barium meal X-ray.The jejunal dilatation was compared between the two groups,and the examination time and radiologic stay time were calculated.
Results
The situation of jejunum dilatation in the observation group was significantly better than that in the control group,and the difference was statistically significant(χ
2
=11.960,P＜0.05).The time-consuming examination and the stay time of radiology department in the observation group were shorter than those in the control group,the difference was statistically significant(P＜0.05).
Conclusion
For inflammatory bowel disease,application of multi-slice spiral CT examination can effectively increase the diagnostic rate,shorten the examination duration,and improve the efficiency of clinical diagnosis.
2018 Vol. 25 (12): 79-81 [
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152
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82
Multislice spiral computed tomography performance and misdiagnosis factor analysis of small intestine diverticulum
SHEN Qian-cheng;FAN Jun-fei;ZHANG Hong
Objective
To evaluate the diagnostic value of multislice spiral computed tomography （MSCT） in small bowel diverticulum and to analyze the common misdiagnosis reasons of small bowel diverticulum.
Methods
From January 2015 to December 2017,30 patients from outpatient clinics and hospitalization diagnosed as small intestine diverticulum by plain and enhanced CT scans on upper abdomen and 25 patients who were initially diagnosed as non-small bowel diverticulum but eventually proved were enrolled in our hospital in order to analyze the MSCT performance and the misdiagnosis reasons of these patients.
Results
The final definite diagnosis of small bowel diverticulum was in 55 patients mostly presenting with protrusion to the enteric cavity and gas or gas-liquid mixed density.The simple manifestation was less liquid density shadow.The diverticulum frequently located at the descending segment and the junction between the descending segment and the horizontal segment of duodenum,with little chance to be in horizontal segment.The small intestine diverticulum was mostly complicated with gastrointestinal diseases such as gallbladder stones and esophageal hiatal hernia,etc.The small intestine diverticulum in clinical practice was more likely to be misdiagnosed as intestinal obstruction,intestinal hemorrhage and perforation,inguinal hernia,appendicitis,which were mainly associated with single clinical manifestation and anatomic site of the small intestine diverticulum.
Conclusion
MSCT has a high value for the diagnosis of small bowel diverticulum,but it is easy to diagnose small bowel diverticulum as other diseases in the clinic.Therefore,attention should be paid to differential diagnosis.
2018 Vol. 25 (12): 82-84转87 [
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156
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85
Application value of X-ray and CT in the diagnosis of knee joint injury
ZHU Xiao-cheng;HE Mei-xiang
Objective
To compared and evaluate the value of X-ray and CT diagnosis in knee joint injury.
Methods
From July 2016 to July 2017,100 patients with knee joint injury were selected in Chancheng Hi-tech Zone Hospitaland Lecong Hospital,Shunde District,Foshan City,Guangdong Province,hospital,all patients were diagnosed by X-ray and CT,and the surgical results were taken as diagnostic criteria.The detection rate,fracture collapse and splitting distance of the types of injury (ligament injury,meniscal injury and tibial plateau fracture)diagnosed between the two groups were compared.
Results
There was no significant difference between CT diagnosis and surgical results(P＞0.05).And CT diagnosis in fracture collapse,splitting distance results were more close to the surgical results,the difference was not statistically significant(P＞0.05).X-ray diagnosis and surgical results between the types of injury(ligament injury,meniscal injury,tibial plateau fracture)detection rate comparison,the difference was statistically significant(P＜0.05);X-ray diagnosis in fracture collapse,splitting distance between the results and surgical results,the difference was statistically significant(P＜0.05).The detection rate of X-ray diagnosis was 90.00%(90/100)which was lower than that of CT diagnosis[99.00%(99/100)],the difference was statistically significant(P＜0.05).
Conclusion
For knee injury patients,the application value of CT diagnosis is more remarkable compared with that by X-ray,and the former can effectively and accurately reflect the knee joint injury.
2018 Vol. 25 (12): 85-87 [
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115
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88
The efficacy and safety of Weiyankang Capsule in the treatment of bile reflux gastritis
DAI Xiao-min
Objective
To explore the clinical efficacy and safety of Weiyanang Capsule in the treatment of bile reflux esophagitis.
Methods
A total of 120 patients with bile reflux gastritis treateed in our hospital from May 2015 to May 2017 were selected as subjects and divided into the observation group and the control group by dynamic random grouping method,60 cases in each group.The control group was treated with Hydrotalcite Tablets,while the observation group was given the auxiliary treatment of Weiyankang Capsule on the basis of the control group.The clinical effects were observed between the two groups.And the clinical symptom scores,gastric acid secretion,astric juice cholic acid content,plasma motilin (MTL)and serum vasoactive intestinal peptide (VIP)before and after treatment were compared between the two groups.
Results
The total effective rate of the observation group(96.7%)was significantly higher than that in the control group of 85.0%,the difference was statistically significant(P＜0.05).Before treatment,there was no significant difference in symptom score,gastric acid secretion,cholic acid in gastric juice,serum VIP and plasma MTL between the two groups(P＞0.05).The symptom score,gastric acid secretion,gastric acid and serum VIP after treament of two groups were significantly lower than before treatment,the differences were statistically significant(P＜0.05).And after treatment,these indexs of the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).After treatment,the plasma MTL after treament of two groups were significantly higher than before treatment(P＜0.05),and the plasma MTL in the observation group was significantly higher than that in the control group,the differences were statistically significant(P＜0.05).There were none adverse drug reactions in the two groups.
Conclusion
Weiyankang Capsule is an effective adjuvant therapy for bile reflux gastritis.It can significantly improve the clinical effective rate,improve various examination indexes,and is highly safe.It is worthy of popularization and application.
2018 Vol. 25 (12): 88-91 [
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166
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92
Distribution and drug resistance of pathogenic bacteria in traumatic fractures of limbs in our hospital from 2014 to 2016
SHEN Li-hua;CHEN Bi-qing
Objective
To analyze the distribution and drug resistance of pathogenic bacteria in traumatic fractures of limbs in our hospital from 2014 to 2016.
Methods
Eighty patients of traumatic fracture of extremities（open fracture in 45 cases and closed fracture in 35 cases）with confirmed pathogenic bacteria infection in our hospital from March 2014 to June 2016 were selected as subjects for medical record analysis.Pathogen distribution and drug susceptibility results were surveyed.
Results
Among the 80 patients,75 cases were single pathogenic bacteria (93.75%)and 5 cases were mixed infections(6.25%).A total of 85 strains were detected,of which 52 strains were Gram-positive bacteria(61.18%),33 strains were Gram-negative bacteria(accounting for 38.82%).Staphylococcus aureus and Staphylococcus epidermidis were all resistant to Penicillin,the resistance rate was 100%,while the resistance did not show to Tigecycline and Linezolid.Escherichia coli and Enterobacter cloacae were resistant to Cefazolin,the resistance rate was 100%,and the resistance of Enterobacter cloacae to Ampicillin and Sulbactam were 100%,while Escherichia coli did not show resistance to Piperacillin and Erythromycin.
Conclusion
s Gram-positive bacteria are the main pathogenic bacteria of traumatic fractures of limbs in our hospital from 2014 to 2016.The clinical treatment should be combined with specific drug susceptibility test results to choose antibacterial drugs.
2018 Vol. 25 (12): 92-94 [
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160
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95
Effect of emergency cervical cerclage combined with Atosiban in the treatment of cervical incompetence
LIU Yu;YIN Bao-min
Objective
To study and analyze the clinical efficacy of emergency cervical cerclage combined with Atosiban in the treatment of cervical incompetence.
Methods
Sixty patients with cervical incompetence treated in our hospital from September 2016 to September 2017 were selected as subjects.They were divided into two groups by random number table method,with 30 patients in each group.All patients were provided with emergency cervical cerclage.The patients in the observation group,besides the emergency cervical cerclage,Atosiban was added.The indexes of delivery mode,the delayed gestational period and fetal Apgar score between the two groups were observed and recorded.
Results
In the observation group,the delayed gestational period were significantly longer than those in the control group,the difference was statistically significant(P＜0.05).The fetal Apgar score in the observation group was much higher than that in the control group,the difference was statistically significant(P＜0.05).The rate of natural childbirth in the observation group was significantly higher than that in the control group(P＜0.05).
Conclusion
The combination of emergency cervical cerclage and Atosiban can effectively prolong the pregnancy time in patients with cervical incompetence,improve the outcomes of maternal and newborn,and increase the proportion of spontaneous delivery of pregnant women,which should be widely promoted in the clinic.
2018 Vol. 25 (12): 95-97 [
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165
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98
Effect of Compound Danshen Dripping Pills combined with Trimetazidine in the treament of chronic congestive heart failure
WANG Yong;LIANG Yu-ming
Objective
To explore and analyze the clinical efficacy of Compound Danshen Dripping Pills combined with Trimetazidine in the treatment of chronic congestive heart failure(CHF)and its influence on the level of high-sensitivity C-reactive protein (hs-CRP).
Methods
A total of 164 patients with chronic CHF treated in the department of cardiology in our hospital from March 2016 to April 2017 were selected as research objects.They were divided into control group(n=81)and observation group(n=83)according to the random number table method.Basic treatment was provided in both.Besides,Trimetazidine was added in the control group,and Compound Danshen Dripping Pill was used in the observation group on the basis of the control group.The clinical efficacy,changes of hs-CRP and occurrence of adverse reactions were recorded and compared between the two groups.
Results
At the time of discharge,Lee heart failure score was lower than on admission,the 6-minute walking distance and left ventricular ejection fraction (LVEF)were higher in both groups than those on admission with statistical significance(P＜0.05).Besides,the Lee heart failure score in the observation group was lower than that in the control group,and 6-minute walking distance and left ventricular ejection fraction(LVEF)in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).The hs-CRP levels of both groups after discharge and 1 month after discharge were lower than those on admission,and the hs-CRP level after discharge in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).After 1 month of discharge,there was no statistically significant difference in hs-CRP level between the two groups(P＞0.05).There was no significant difference in the incidence of adverse reactions during treatment between the two groups (P＞0.05).
Conclusion
Compound Danshen Dripping Pills combined with Trimetazidine obtains a favorable clinical efficacy in the treatment of chronic CHF,and can effectively reduce the level of hs-CRP,which is worthy of clinical application and promotion
2018 Vol. 25 (12): 98-100转103 [
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157
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101
Effect of Colloidal Bismuth Pectin combined with Amoxicillin in the treatment of chronic atrophic gastritis
ZHANG Ming-qiu
Objective
To explore the clinical effect of Colloidal Bismuth Pectin combined with Amoxicillin in the treatment of chronic atrophic gastritis.
Methods
A total of 96 patients with chronic atrophic gastritis admitted to our hospital from May 15,2017 to December 20,2017 were selected as the study subjects.The patients were divided into two groups by a random number table method,with 48 patients in each group.Patients in observation group were treated with Colloidal Bismuth Pectin combined with Amoxicillin,while in control group,they were treated with Clarithromycin and Colloidal Bismuth Pectin.The total clinical effectiveness rate and incidence of adverse drug reactions such as dizziness,rash,and nausea were compared between the two groups.
Results
The total effectiveness rate in the observation group was 95.83%,which was higher than that of the control group accounting for 72.92%with statistical significance (P＜0.05).The incidence of adverse drug reactions was 4.17%,which was lower than that in the control group accounting for 20.83%with a significant difference(P＜0.05).
Conclusion
The combination of Colloidal Bismuth Pectin and Amoxicillin in the treatment of chronic atrophic gastritis is of high clinical value.It can relieve clinical symptoms,which is worthy of application and promotion.
2018 Vol. 25 (12): 101-103 [
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139
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104
Experience discussion of Professor WANG Guo-hua treating polycystic ovary syndrome with insulin resistance starting with mediating zhongzhou
PANG Ying;WANG Guo-hua; LIU Jin-feng;CHEN Rui-fen\
The incidence of polycystic ovary syndrome (PCOS)is increasing rapidly in women of childbearing age,and most of them are accompanied by insulin resistance(IR).Professor WANG Guo-hua believed that nowadays,the change of lifestyle and the increase of women′s working pressure make spleen asthenia and qi depression become the key reasons for the onset of PCOS-IR.According to professor WANG Guo-hua clinical experience,due to syndrome differentiation,treatment for this,the effect of treating PCOS-IR starting with mediating zhongzhou is exact,and it has important guiding significance for treating PCOS with traditional Chinese Medicine.
2018 Vol. 25 (12): 104-107 [
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149
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108
Influence of auricular points plaster therapy on intervention effect of overabundant liver-fire type hypertension
WANG Ling-li;JIANG Yan;YUAN Yuan-chuan-zi
Objective
To discuss the intervention effect of auricular points plaster therapy on overabundant liver-fire type hypertension.
Methods
Eighty patients with overabundant liver-fire type hypertension managed by Binhe Community Health Center,Maternal and Child Health Hospital of Futian District in Shenzhen City from February 2016 to October 2017 were selected,and they were divided into the two groups according to the random number method,there were 40 cases in each group.The control group was treated with conventional western medicine,while the study group was given auricular points plaster intervention therapy.Blood pressure control,sleep quality and quality of life and so on were compared in patients between the two groups.
Results
The total effective rate of the study group was 95.00%,which was higher than that of the control group(82.50%),and the difference was statistically significant(P＜0.05).There was no significant difference in the indexes of SBP and DBP before treatment btween the two groups(P＞0.05),and the indexes of SBP and DBP after 1,2,3 and 4 weeks treatment in the study group were lower than those in the control group,and the difference were statistically significant(P＜0.05).There was no significant difference in the sleep quality score between the two groups before treatment(P＞0.05).After treatment,the sleep quality score of the patients in the study group was higher than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the SF-36 score between the two groups before treatment(P＞0.05).After the treatment,SF-36 score of the patients in the study group was higher than that of the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Auricular points plaster therapy treating overabundant liver-fire type hypertension can better control the blood pressure of patients,and it plays an important role in improving sleep quality and life quality,and can improve the therapeutic effect and is worthy of promotion.
2018 Vol. 25 (12): 108-111 [
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127
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112
Pro.CHEN Zhi-gang′s experience in treating peripheral neuropathy based on disease differentiation
YANG Ling;CHEN Zhi-gang
Peripheral neuropathy disease have complex etiologies,various courses and diverse clinical manifestations.Disease differentiation treatment is proposed by professor CHEN Zhi-gang,which is based on different courses and etiologies according to the classification of peripheral neuropathy in western medicine.Acute/subacute peripheral neuropathy is associated with exogenous pathogens,and removing pathogens is considered to be the primary treatment,supplementing qi and blood should be emphasized.Chronic peripheral neuropathy should be considered in terms of internal and accumulated damages.It is necessary to identify the problem according to syndrome differentiation of sanjiao theory.In addition to emphasizing qi and blood,invigorating kidney drugs should be properly used.The recurrent peripheral neuropathy needs to be understood from the perspective of"hidden pathogen theory".Its core pathogenesis is deficiency of vital qi,disorder of zang and fu viscera generating turbid phlegm,toxin and stasis.Treatment should be"benefiting vital qi,resolving phlegm and removing toxicity".
2018 Vol. 25 (12): 112-115 [
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155
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116
Effect study of ischemic pretreatment on improving the prognosis of reperfusion injury after cerebral ischemia
XIE Kai-sheng;PAN Qing-fei;HUANG Xian;LI Sheng-hai;HE Xiu-li
Objective
To investigate the effect of ischemic pretreatment on improving the prognosis of cerebral ischemia-reperfusion injury.
Methods
A total of 75 healthy male mice were randomly divided into 3 groups:sham operation group(n=15),control group(n=28)and observation group(n=32).In the sham operation group,only right common carotid artery was ligated.In the observation and control groups,the cerebral ischemic model in mice was established by suture method.The mice were reperfused 24 hours after ischemia for 2 hours.In the control group,saline was used before perfusion,while in the observation group,ceftriaxone was applied.The infarct volume,neurological deficit scores and interleukin-1β (IL-1β)inflammatory cytokines levels in the three groups of mice were observed.
Results
The score of neurological function in the observation group was higher than that in the control group.The level of IL-1β in the cortex was lower than that in the control group.The volume of cerebral infarction was smaller than that in the control group,the difference was statistically significant(P<0.05).The levels of inflammatory cytokines and infarcted volume of corpus striatum were not displayed statistical differences(P>0.05).The scores of neurological function in the sham operation group were higher than those in control group and observation group.The IL-1β level and infarct volume in the sham operation group were also lower than those in the other two groups,,the difference was statistically significant(P<0.05).
Conclusion
Application of ceftriaxone for pretreatment before cerebral ischemia-reperfusion can decrease the expression and secretion of IL-1β inflammatory factor,effectively reduce the volume of cerebral infarction,and alleviate neurological deficit.
2018 Vol. 25 (12): 116-118 [
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139
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119
Detection of cytomegalovirus in children with cytomegalovirus infection by urine samples at different time intervals
HUANG Bin;LIU Su-yun;WAN Li-jia;LIU Ming;WU Xiao-yang;LUO Qin
Objective
To investigate the effect of fluorescent quantitative PCR in detection of cytomegalovirus(HCMV)in urine samples of children with HCMV infection at different time intervals.
Methods
A total of 30 cases of infection in our hospital from September 2015 to February 2017 in Department of Pediatrics of infected children,for all children were collected in the morning urine as morning urine group,collecting urine specimens as random specimens from other time periods,the application of real-time fluorescence quantitative PCR technology in different periods of urine HCMV DNA level standard for examination,the positive detection rate was compared between the two groups.
Results
The results showed that morning urine group,27 cases were detected HCMV positive,the detection rate of 90.00%,random time urine group,20 cases were detected HCMV positive,the detection rate of 66.67%,compared the two groups,morning urine group was significantly higher than that of random time group,the difference was statistically significant(P<0.05).
Conclusion
The detection of HCMV real-time fluorescent quantitative PCR in children with infection of HCMV in children,collection of morning urine samples for testing,the positive rate is high,effectively reduce the misdiagnosis,it is worth in clinical application.
2018 Vol. 25 (12): 119-121 [
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134
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122
Analysis of PCT and CRP combined detection in the diagnosis of neonatal infectious diseases
LI Fu;YANG Xiao-mei;WU Chun-hong;WEI Lin-Yan;LAN Jin-sheng
Objective
To study the value of combined detection of calcitonin(PCT)and C-reactive protein(CRP)in the diagnosis of neonatal infectious diseases.
Methods
Participants 44 newborns(observation group)and 44 normal newborns(control group)admitted to our hospital from March 2016 to April 2017 were enrolled in this study.Infections were collected before treatment 3 ml venous in children with disease and 3 ml venous blood in control group within 7 days after birth.PCT and CRP were measured in two groups.Venous blood before treatment and 10 days after treatment were collected in the observation group,CRP,neutrophil(NEUT)content,using Spearman rank correlation coefficient test PCT,CRP NEUT content correlation.
Results
The serum levels of PCT and CRP in the two groups were significantly higher than those in the control group (P<0.05).The positive rate of PCT and CRP in the observation group was significantly higher than that in the control group(P<0.05).The levels of PCT,CRP and NEUT in the observation group were significantly lower than those before treatment,the differences were statistically significant(P<0.05).The results of PCT,CRP and NEUT were based on the Spearman rank correlation coefficient.The results showed that PCT,CRP and NEUT were related(P<0.05).
Conclusion
PCT and CRP haveimportant value in the early diagnosis of neonatal infectious diseases,determine the degree of infection,and determine the therapeutic effect,and apply them to clinical practice.
2018 Vol. 25 (12): 122-124 [
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160
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125
Diagnostic value of P16/Ki-67 immunocytochemistry double staining for cervical precancerous lesions
FANG Jia;CHEN Feng-yan
Objective
To explore the application of P16/Ki-67 immunocytochemistry double staining in the diagnosis of cervical precancerous lesions for its accuracy.
Methods
A total of 900 patients with cervical precancerous lesions who were treated in our hospital from May 2016 to March 2017 were selected.Each patient was provided with P16/Ki-67 immunochemistry double staining assay and thinprep cytologic test(TCT)for human papilloma virus DNA.The positive rate of cervical precancerous lesions was detected using P16/Ki-67 immunochemistry double staining method.The pathological biopsy results were set as the gold standard,the accuracy of P16/Ki-67 immunochemistry double staining and TCT detecting cervical precancerous lesions was assessed.
Results
Among 900 participants,54 subjects were examined as positivity by pathological biopsy.The specificity and sensitivity of P16/Ki-67 immunocytochemistry double staining for cervical precancerous lesions were 82.3%(696/846)and 92.6%(50/54).By TCT,they were 68.6%(580/846)and 62.9%(34/54)respectively.Compared with the two examination methods,the specificity and sensitivity of P16/Ki-67 immunocytochemistry double staining were superior to those by TCT with significant differences(P<0.05).
Conclusion
The detection of P16/Ki-67 immunocytochemistry double staining can improve the diagnostic accuracy of cervical precancerous lesions in a definite effect,which is worthy of clinical promotion.
2018 Vol. 25 (12): 125-127 [
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139
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128
Impacts and countermeasure of per disease scoring of medical insurance on management of Medical record
LI Shao-ling
On January 1,2018,Huizhou,Guangdong province began to implement the method of settlement of the hospitalization expenses under the total control of the disease.The new settlement method takes the main diagnostic icd-10 code as the reference standard,forcing the hospital to strengthen the management of the home page of medical records,and standardize medical information upload.This study mainly focuses on the implementation background of the settlement method and the requirements and countermeasures of hospital case management,so as to better cope with the reform of the insurance payment system.
2018 Vol. 25 (12): 128-130 [
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124
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131
Analysis and suggestions on quality of warehouse entry inspection of Chinese decoction pieces in a hospital
JIANG Ya-qin
Objective
To put forward some suggestions to guarantee the quality of clinical medication by analyzing the quality of warehouse entry inspection of Chinese decoction pieces in a hospital.
Methods
According to the records of warehouse entry inspection of Chinese decoction pieces in a hospital from January 2016 to June 2017,the reasons for unqualified Chinese decoction pieces were summarized and analyzed.
Results
There were 2623 batches of Chinese decoction medicine checked and accepted in a hospital,of which 136 batches pieces were unqualified,accounting for batches of 5.18%of total acceptance.The reasons of unqualified Chinese decoction pieces mainly included deterioration,adulteration and non-standard processing,which accounted for 52.94%of total unqualified batches.
Conclusion
Some suggestions were put forward to guarantee the quality of clinical medication in view of the problems found in the warehouse entry inspection of Chinese decoction pieces in a hospital,which included to strengthen the purchasing management of Chinese decoction pieces,to improve the acceptance level of staff,and to standardize the processing of Chinese decoction pieces.
2018 Vol. 25 (12): 131-133转1136 [
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127
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134
Significance of continuous quality improvement to the Management of Disinfection supply Room
LI Mu-ping;HUANG Reng-xin;ZHU Li-chan
Objective
To explore the clinical value of continuous quality improvement in the management of disinfection supply room.
Methods
Five hundred samples of disinfection disinfection and supply room in our hospital from March 2015 to February 2016 were selected as the observation object,and divided into two groups according to random draw method,namely the normal group(n=250)and improved group(n=250).Routine management of disinfection samples was carried out in routine group,and continuous quality improvement management was carried out in improved group.The packing quality,sterilization quality,cleaning quality and the time of sending samples to the department were compared between the two groups.
Results
The unqualified rate of disinfection samples,the unqualified rate of sterilization quality and the unqualified rate of cleaning quality in the improved group were 0.80%,0.40%,0.40%,which were significantly lower than those in the conventional group for 3.60%,2.80%and 2.80%,respectively,and the difference between the two groups was statistically significant(P＜0.05).The improved group samples sent to the department of disinfection time was significantly shorter than the conventional group according to the number of disinfection samples,respectively (41.43±11.42)min,(59.45±14.43)min,there were significant differences between the groups(P＜0.05).
Conclusion
The clinical value of continuous quality improvement measures in the management of disinfection supply room is more significant.It can effectively improve the quality of packaging,sterilization quality,cleaning quality,shorten the time of goods sent to department,and has a very positive significance for preventing nosocomial infection.
2018 Vol. 25 (12): 134-136 [
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131
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137
The implementation and effectiveness of nursing management measures in hospitals
XU AI-xia;LIU Shan-feng
Objective
To explore the risk factors of nursing risk events and the effectiveness of hospital nursing management measures.
Methods
Ninety cases of patients with risk events in Yi′nan Maternal and Child Health-Care Hospital were collected and analyzed retrospectively to investigate the risk factors of nursing risk events from January 2015 to December 2017.In addition,84 nurses from different departments of our hospital were selected to investigate the implementation of hospital management measures by self-made questionnaire.
Results
Ninety cases of nursing risk events were mainly caused by improper nursing management and patient′s own factors,71 cases (78.89%)and 19 cases(21.11%),respectively.The main reason for the improper nursing management was the low responsibility of medical staff(38.89%).The survey results of hospital nursing management measures showed that the implementation of hospital personnel management was better,but the quality management and staff welfare measures were not good,the defferents were statistically significant(χ
2
=5.682,P＜0.05).
Conclusion
The nursing management measures in the hospital can strengthen the human resources of the hospital,improve the comprehensive quality of the hospital nursing.Improving the sense of responsibility of medical nurses is of great importance for reducing the occurrence of nursing risk events.
2018 Vol. 25 (12): 137-139 [
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145
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140
Effect of Hospital-Community Integrated Management on blood glucose control in elderly patients with type 2 diabetes
WAN Lei;DONG Kun
Objective
To investigate the effect of hospital-community integrated management on blood glucose control in elderly patients with type 2 diabetes.
Methods
A total of 120 elderly patients with type 2 diabetes from September 2015 to September 2016 treated in our community health service center were selected as study subjects,and divided into the traditional group (n=60)and the integrated group (n=60)according to the random number table method.The patients in traditional group were treated by traditional hospital management.The patients in integrated group were treated with hospital-community integrated management mode.The blood glucose control effect,cognitive knowledge of diabetes knowledge and treatment compliance were compared between the two groups.
Results
After one year of management,the fasting blood glucose of patients in integrated group was lower than that of the traditional group at 2 h after meal.The difference was statistically significant(P＜0.05).Cognitive score of diabetes knowledge and treatment compliance in the integrated group were higher than those in the traditional group (P＜0.05).
Conclusion
The hospital-community integrated management model for elderly type 2 diabetes patients can improve the blood sugar control effect.
2018 Vol. 25 (12): 140-142 [
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124
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143
Application of homemade Y-tube in exhaust emissions during laparoscopic surgery
PENG Hui;LUO Shao-fang;WU Li-hua;LIN Zhou-mei;HUANG Yu-mei
Objective
To investigate the application effect of homemade Y-tube on exhaust emission in the laparoscopic surgery.
Methods
A total of 118 patients undergoing laparoscopic surgery from September 2016 to June 2017 in our hospital were selected and evenly divided into control group and observation group by drawing lots method,59 cases in each group.In the control group,traditional pneumoperitoneum tube was used,and in the observation group,homemade Y-tube was adopted.The intraoperative handling time of pneumoperitoneum tube,the average application cost,the average hemostasis time,the effectiveness rate of application and the satisfaction of medical staff were compared between the two groups.
Results
In the observation group,the handling time of pneumoperitoneum tube and average hemostasis time were all shorter than those in the control group,average application cost was lowser than that in the control group,with statistical differences(P<0.05).The effectiveness rate of application in the observation group was 94.92%,higher than that in the control group accounting for 81.36%,with a statistical difference(P<0.05).The satisfaction rate of medical staff on tube application in the observation group was 96.61%,higher than that in the control group accounting for 84.75%,which difference was statistically significant(P<0.05).
Conclusion
The application of homemade Y-tube in laparoscopic surgery does not affect the smooth operation,and has the advantages of shortening the exhaust time,reducing air pollution and decreasing the operating cost,which is worthy of promotion.
2018 Vol. 25 (12): 143-145 [
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126
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146
Comparison of the prophylactic effect of silica gel decompression body pad and multi layer soft silica gel foam dressing with surgical pressure injury on long time pediatric neurosurgery
RAO Zhi-ming
Objective
To study the effect of silica gel pad and multilayer decompression body soft silicone foam dressing on the effect of long time operation of pediatric neurosurgery.
Methods
A total of 112 patients undergoing neurosurgery from February 2015 to June 2017 in our hospital were selected as research subjects.The patients were divided into the observation group and the control group according to the random number table method,56 cases in each group.The control group was given routined nursing and silicone gel decompression position pad,the observation group was treated with conventional nursing and multi-layer soft silicone foam dressing and the occurrence of surgical pressure injury and the satisfaction of parents were compared between the two groups.
Results
The incidence of bedsore in the observation group was 1.79%,which was significantly lower than that in the control group 12.50%(P<0.05).The parents′satisfaction was 98.21%in the observation group,which was higher than that in the control group of 87.56%,the difference was statistically significant(P<0.05).
Conclusion
The application of multi layer soft silica gel foam dressing in the long operation of children department of neurosurgery has a more obvious effect on preventing surgical pressure injury.And it can improve the childrens parents′satisfaction effectivelyit is worth to applying.
2018 Vol. 25 (12): 146-148 [
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144
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149
Two cases of failure analysis and maintenance of GE-MA5500 electrocardiograph
HAO Mei-shuo
This paper discusses the maintenance methods of two cases of special fault maintenance of GE-MA5500 electrocardiograph.By analyzing the causes of the failure of the GE-MA5500 printing report,the failure source was found and the maintenance and maintenance was carried out.The result shows that a set of data lines was broken which causes the printing information to be unable to feed back to the control board,causing the failure.The 2 cases described in this paper are relatively rare,especially in first cases.We need to be patient reference to find out the source of failure.
2018 Vol. 25 (12): 149-151 [
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127
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152
Effect of pension pattern of integrated treatment and convalesce in elderly patients with coronary heart disease
JIANG Xiu-fang;WANG Hao;SU Hui-zhi;QIAO Yi-ling;YANG Xiao-li;ZHANG Yan
Objective
To investigate the clinical value of pension pattern of integrated treatment and convalesce in elderly patients with coronary heart disease.
Methods
A total of 80 elderly patients with coronary heart disease admitted in our hospital from January 2015 to December 2016 were selected as subjects and randomly divided into observation group and control group according to randow number table method,40 cases in each group.The patients in the control group were underwent routine pension pattern,the observation group were implemented with pattern of integrated treatment and convalesce.The monthly living expenses and medical expenses were compared between the two groups.The incidence of medical related diseases,mortality and serious complications during the follow up period between the two groups were compared.
Results
The monthly living expenses and medical expenses in the observation group were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).The incidence of hypertension,chronic obstructive pulmonary disease,diabetes and hyperlipidemia in the observation group were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).After 1 year follow-up,the rates of death and serious complication were significantly lower than control group,the differences were statistically significant(P＜0.05).
Conclusion
The pension pattern of integrated treatment and convalesce is gradually new and effective mode medical care for the elderly,which can effectively reduce the living and medical expenses of patients and reduce the complications and prolong the survival time.
2018 Vol. 25 (12): 152-154 [
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133
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155
Study on the role of health education in new infectious diseases and its control countermeasures
WANG Feng;LIU Xiao-hua
Objective
To analyze the clinical effect of health education in new infectious diseases.
Methods
A total of 1000 residents in the area of the disease control and prevention center from August 2017 to April 2015 were selected as the subjects,and the health education intervention was carried out from May to August in 2016.The status of health knowledge of the residents,the control of health behaviors and the incidence of infectious diseases before and after the implementation of education were compared.
Results
Before the implementation of health education,the health knowledge awareness score of 1000 residents was (73.2±3.5)points.After the implementation of health education,the score was(91.3±5.6)points.The health education score after the implementation of health education was significantly higher than that of before the implementation of health education,the difference was statistically significant(P＜0.05).After the implementation of health education,the rate of smoking and drinking and excessive intake of salt were significantly lower than that before the implementation of health education,the probability of participating in physical exercise was significantly higher than that before the implementation of health education,infectious disease incidence was significantly lower than before the implementation of health education,and the differences were statistically significant(P＜0.05).
Conclusion
Health education can play an effective role in the treatment of new infectious diseases,and the prevention and control of new infectious diseases should be increased and the level of prevention should be improved.
2018 Vol. 25 (12): 155-157 [
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132
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158
Detection results analysis of the health monitoring microorganisms in public places in a district of Huizhou City in 2015
YE Shi-xing;XU Wei-bing
Objective
To analyze the detection results of the health monitoring microorganisms in public places in Huiyang District and to provide reference for the health supervision and monitoring of public places in this area.
Methods
The hotel inn,beauty salon,culture and entertainment venues,and shopping malls in this area were selected as monitoring objects.From January to December in 2015,the air and public goods were collected and tested in order to analyze the health status of public places in this district.
Results
There were 814 air samples in public places,and 751 of them were qualified accounting for 92.23%.Among 1844 copies of public supplies,1761 were qualified accounting for 95.50%.
Conclusion
Generally,the public health conditions in public places in this area are in good condition,but there are still some improvement.Health supervision in public places should be intensified,and training of relevant laws,regulations and health knowledge for employees should be strengthened in order to improve the hygiene awareness of employees.
2018 Vol. 25 (12): 158-160 [
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167
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161
Effect observation of hand hygiene intervention in improvement of the hand hygiene compliance rate for medical staff
LI Leng-mei;SONG Xiao-mei;ZHU Feng-wan
Objective
To explore the effect of hand hygiene intervention in improvement of hand hygiene compliance rate for medical staff.
Methods
Altogether 96 cases of medical personnel who worked in our hospital from January to November in 2017 were selected as the subjects.An investigation on medical personnel′s awareness of hand hygiene knowledge,hand hygiene compliance rate and practice accuracy was conducted.After investigation,intervention was given according to the actual situation of medical personnel′s hand hygiene.After implementation of the intervention,its effectiveness in actual hand hygiene situation,hand hygiene knowledge awareness rate,compliance rate and practice accuracy was analyzed for medical staff.
Results
The post-interventional number of colonies ([1.7±1.1]cfu/ml)after hand washing was significantly lower than that before the intervention([9.1±3.5]cfu/ml),the difference was statistically significant(P＜0.05).The post-interventional hand hygiene knowledge awareness rate score and hand hygiene compliance rate were significantly higher than those before intervention,the difference was statistically significant(P＜0.05).The post-interventional hand hygiene practice accuracy of medical staff was 95.8%,significantly higher than that before the intervention(41.7%),the difference was statistically significant(P＜0.05).
Conclusion
Hand hygiene intervention can improve the hand hygiene compliance rate of medical staff.
2018 Vol. 25 (12): 161-163 [
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157
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164
Application of mobile WeChat+flipped classroom in the teaching of traditional chinese medicine psychology
YANG Bo;YANG Ping; WANG Le-zhou
Objective
To observe the effect of Mobile WeChat+flipped classroom method in the teaching of traditional Chinese medicine psychology.
Methods
A total of 80 students majoring at clinical psychology from Hunan University of Chinese Medicine in 2014 were selected as object and they were divided into the the control and experimental groups(n=40)according to the random number method.The control group received traditional teaching methods,while the experimental group was given the modern teaching method of mobile WeChat combined with flipped classroom.The teaching quality between the two groups were compared.
Results
The results of the online test and video speaking in the experimental group were significantly higher than those in the control group(P<0.05).The scores of some items in the experimental group were significantly higher than those in the control group,including the liking degree to the teaching method,satisfactory degree to the teaching method,effect and efficiency of the study,improving the interesting and activity successfully,improving the ability of thinking independently successfully,promoting improving the ability of self-study and communicating in class,promoting improving the ability of analysing and solving problems,independence,flexibility and cooperation in class(P<0.05 or<0.01).There were no statistical difference in improving the ability of self-study and communicating successfully in class (P＞0.05).
Conclusion
The teaching method of Mobile WeChat+flipped classroom can improve the teaching quality in traditional Chinese medicine psychology.
2018 Vol. 25 (12): 164-166转169 [
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116
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167
Effect discussion of combined application of various teaching methods on practice teaching in paediatric nursing
QIU Jian-jing; ZHU Xi-mei;LI Feng-mei
Objective
To explore the effect of combined application of nursing program teaching method and project teaching method on pediatric nursing practice teaching.
Methods
Ninety nursing students of our department from March to September in 2016 working during the internship period were selected as the observation objects.They were divided into the study group and control group according to the principle of random distribution.45 students in the study group were given nursing program teaching method and project teaching method.45 students in the control group were given traditional teaching method.The theoretical test scores and questionnaire survey results between the two groups were compared.
Results
The theoretical total score of students in the study group was(89.43±7.12)points,which was significantly higher than that of the control group,and there was a statistical difference between the two groups(P<0.05).The questionnaire survey of two groups showed that the total satisfaction rate in the study group was 93.33%,which was slightly higher than that was 84.44%in the control group,and there was no significant difference between the two groups(P>0.05).
Results
Compared with the traditional routine teaching methods,the effect of the combination of nursing program teaching method and project teaching method in pediatric nursing practice teaching is obvious,and has certain popularization and application significance in the later practice teaching,which can improve the teaching effect and teaching quality,then to further improve the satisfaction rate of doctors and patients and the quality of hospital service.
2018 Vol. 25 (12): 167-169 [
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127
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170
Application analysis of nursing safety education in the teaching of nursing technical operation
YUAN Jing;WANG Dan;LI Li-ping
Objective
To explore the application effect of nursing safety education in the teaching of nursing technical operation.
Methods
Eighty student nurses were studied according to the random sampling method from student nurses from July 2015 to March 2017.According to different teaching model,they were divided into the control group and observation group,and there were 40 students in each group.The student nurses in the control group were provided with the traditional teaching mode of nursing operation,while in the observation group,on the basis of the control group,the nursing safety education was strengthened.After the end of internship,the nursing education was evaluated.A comprehensive assessment was carried out in the two groups.
Results
After the end of internship,the theoretical score in the observation group was(87.23±4.50)points,which was significantly higher than that of the control group([75.21±3.84]points)(P<0.05).The scores of operation ability and nursing safety were also displayed statistical significance between the two groups(P<0.05).The nursing safety score of the nursing students in the observation group was significantly higher than that of the control group(P<0.05),and there was no significant difference in the other scores of the two groups(P>0.05).
Conclusion
In the process of clinical nursing teaching,intensification of nursing safety education is beneficial for reduction of the occurrence of nursing adverse events,ensures the nursing efficiency and improves the academic performance in the student nurses.Therefore,the nursing safety education is worthy of comprehensive promotion in the clinical nursing teaching process.
2018 Vol. 25 (12): 170-172 [
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121
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173
Application of acupuncture and TCM nursing care after the limb surgery
LIANG Chao-ling;WEI Man;YANG Li-juan;LI Huan-xi;ZHONG Cheng
Objective
To explore the clinical application of acupuncture and TCM nursing care after the orthopedics surgery.
Methods
From June 2016 to November 2017,80 patients with orthopedic limb postoperative pain in our hospital were selected as the research object,and divided into control group and study group by digital parity method,40 cases in each group.The study group was treated with acupuncture combined with traditional Chinese medicine nursing,while the control group was treated with routine treatment.The analgesic effect of the two groups was compared.
Results
There was no significant difference in NRS scores between the two groups before treatment （P＞0.05）.The NRS scores of 12,24 h and 3 d after treatment in the study group were significantly lower than those in the control group,and the difference was statistically significant （P＜0.05）.The incidence of adverse reactions in the study group was significantly lower than that in the control group,and the difference was statistically significant （P＜0.05）.The hospital stay in the study group was shorter than that in the control group,and the difference was statistically significant（P＜0.05）,and the scores of quality of life and satisfaction were higher than those in the control group,and the difference was statistically significant（P＜0.05）.
Conclusion
The combined method of acupuncture and TCM nursing care can quickly relieve the pain,reduce the incidence rate of adverse reactions,shorten the treatment time,improve the life quality and increase the patient′s satisfaction.
2018 Vol. 25 (12): 173-175 [
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139
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176
Application study of evidence-based nursing mode for the prevention of deep venous catheter-related complications during hemodialysis
LIANG Shu-qin
Objective
To investigate the clinical value of evidence-based nursing intervention on the prevention of deep venous catheter-related complications in hemodialysis patients.
Methods
From September 2015 to September 2017,92 cases of hemodialysis patients in our hospital were randomly divided into control group and observation group,46 cases in each group.The control group received routine dialysis nursing intervention during the treatment of indwelling deep venous catheter.Evidence-based nursing intervention was carried out in the observation group during the treatment of indwelling deep venous catheter.The number of complications,the improvement of renal function before and after nursing intervention,and the satisfaction of clinical nursing during the treatment of hemodialysis patients with indwelling deep venous catheter were compared between the two groups.
Results
The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The improvement range of renal function related indexes in the observation group after nursing intervention was greater than that in the control group,and the difference was statistically significant(P＜0.05).The total satisfaction of clinical nursing in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
For hemodialysis patients during deep venous catheter indwelling,evidence-based nursing intervention can effectively prevent the occurrence of related complications,greatly improve the renal function and increase the patient′s satisfaction on nursing services.
2018 Vol. 25 (12): 176-178 [
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132
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179
Effect of intensive nursing in wound care of senile patients with diabetic foot
LI Cheng-ye;YE Fang;YANG Si-wen;HUANG Wen-hua
Objective
To explore the effect of intensive nursing in elderly patients with diabetic foot wounds.
Methods
From October 2016 to October 2017,80 patients with diabetic foot in outpatient department of our hospital were selected and divided into control group and experimental group with 40 patients in each group.Patients in the control group received routine nursing.Patients in the experimental group received meticulous nursing.The difference of nursing satisfaction and anxiety score between the two groups was compared.
Results
The nursing satisfaction of the experimental group was significantly higher than that of the control group(P＜0.05).Before nursing intervention,there was no significant difference in anxiety score between the two groups(P＞0.05).After nursing intervention,the anxiety score of the experimental group was significantly lower than that of the control group(P＜0.05).Before nursing,there was no significant difference in foot condition between the two groups(P＞0.05).After nursing,the improvement degree of foot condition in the experimental group was significantly better than that in the control group(P＜0.05).
Conclusion
Elderly patients with diabetic foot Intensive nursing intervention can improve the patient satisfaction rate of nursing work,effectively improve their psychological status and promote the alleviation of the patient′s condition,it is worth promoting the application.
2018 Vol. 25 (12): 179-182 [
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134
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183
Effectiveness of application of whole-course nursing intervention in patients with diabetic retinopathy
OU Mei-yi;TAN Jie-mei;LIN Xiu-qin;ZHANG Zhi-hui;ZHOU Zhi-hua;XIONG Yi-bin
Objective
To explore the effectiveness of application of whole-course nursing intervention in patients with diabetic retinopathy.
Methods
A total of 100 diabetic retinopathy patients examined by fundus fluorescein angiography in our hospital from January 2017 to December 2017 were randomly divided into control group and study group,50 cases in each group.The control group was given routine nursing,while the study group was given whole-course nursing intervention.The incidence of adverse reactions,symptom checklist 90(SCL-90)scores,anxiety and depression scores and nursing satisfaction were compared between the two groups.
Results
The incidence of fever,vomiting,dizziness,urticaria and total adverse reactions in the study group were significantly lower than those in the control group,and the difference was statistically significant（P＜0.05）,and the scores of SCL-90 in the study group were significantly lower than those in the control group,and the difference was statistically significant （P＜0.05）.There was no significant difference in the scores of anxiety and depression between the two groups before intervention (P＞0.05).After intervention,the scores of anxiety and depression in the study group were significantly lower than those in the control group,and the difference was statistically significant（P＜0.05）.Nursing satisfaction(98.00%)in the study group was significantly higher than that in the control group (80.00%),and the difference was statistically significant （P＜0.05）.
Conclusion
The whole-course nursing intervention can significantly reduce the incidence of adverse reactions and improve patients′bad mood and quality of life in patients with diabetic retinopathy who underwent fundus fluorescein angiography.
2018 Vol. 25 (12): 183-185 [
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129
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186
Application effect of integrative health education for pregnant women in pregnancy
GUAN Jian-kui;WANG Bi-xia;Deng-wei
Objective
s To explore the application effect of selective network interactive health education method for pregnant women with prenatal care.
Methods
From November 2015 to July 2017,114 elderly pregnant women were selected as the experimental objects.The patients were divided into control group and observation group by digital parity method,with 57 cases in each group.The control group chose traditional basic nursing mode,the observation group chose traditional basic nursing+network interactive health education mode.After 3 months of nursing,anxiety and depression,pregnancy health knowledge and self-efficacy scores were compared between the two groups.
Results
After nursing,the scores of anxiety and depression in the observation group were lower than those in the control group,and the difference was statistically significant（P<0.05）.The scores of pregnant health knowledge in the observation group were higher than those in the control group,and the difference was statistically significant （P<0.05）.The self-efficacy score of the elderly pregnant women in the observation group was higher than that in the control group,and the difference was statistically significant（P<0.05）.
Conclusion
Reasonable choice of network interactive internet health education for pregnant women during pregnancy to provide prenatal care,by relieving anxiety and depression in older pregnant women to improve their cognitive awareness of health care during pregnancy and self-efficacy,can significantly improve the comprehensive effect of health care during pregnancy.
2018 Vol. 25 (12): 186-188 [
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152
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189
The influence of improved prenatal health education on improving cognitive behavior and delivery end of labor
HUANG Li-mei
Objective
To explore the role of improved prenatal health education in improving maternal cognitive behavior and delivery outcome.
Methods
From April to December 2016,132 parturients were selected and randomly divided into control group(n=68)and observation group(n=64).the control group was given routine nursing and the observation group was given improved prenatal health education intervention.The clinical data of the two groups were observed and recorded.
Results
The awareness rate of maternal health knowledge in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The scores of psychological status and coping behaviors in the observation group were higher than those in the control group,and the difference was statistically significant(P＜0.05).The proportion of spontaneous delivery in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in Apgar score between the two groups,and the difference was statistically significant(P＞0.05).The amount of bleeding in the observation group was less than that in the control group at 2 hours after delivery,The total labor time was less than that of the control group,and the difference was statistically significant(P＜0.05).The satisfaction rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).
Conclusion
The effect of improved prenatal health education on improving cognitive behavior and delivery end of labor is significant.It can also shorten the maternal total labor process and reduce postpartum hemorrhage,therefore worth to promote the clinical application.
2018 Vol. 25 (12): 189-191 [
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128
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192
The role of deming circulatory method in improving the accuracy of drip rate of scalp intravenous infants
CHEN Li-ping
Objective
To explore the role of Deming Central Loop （PDCA）method in improving the accuracy of drip rate of infantile scalp intravenous infusion.
Methosds
From January to October in 2017,260 cases of scalp venous transfusion in our hospital were selected as the research object.From January to May in 2017,120 children before PDCA cycle method was used were set as control group,and 140 children were after PDCA cycle method was used from June to October in 2017 set as observation group.The defects and accuracy of scalp intravenous infusion dripping rate were observed and compared between the two groups.
Results
The observation group had fewer defects than the control group,and the difference was statistically significant(P＜0.05).The accuracy rate of scalp intravenous infusion was 94.29%(132/140)in the observation group,which was significantly higher than 66.67% (80/120)in the control group,and the difference was statistically significant(χ
2
=32.743,P＜0.05).
Conclusion
The use of PDCA cycle in the treatment of scalp intravenous infusion of children,can effectively reduce the infusion rate of infusion defects,significantly improve the scalp intravenous infusion rate accuracy.
2018 Vol. 25 (12): 192-194转197 [
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128
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Application effect of comfort nursing on perioperative period of breast cancer patients
XU Bo-yuan;YANG Shu-qun;TAN Cai-ji;GUO Chen-hao;YAN Chun-ming;REN Yu
Objective
To investigate the clinical application effect of comfort nursing in perioperative nursing of patients with breast cancer.
Methods
Sixty cases of breast cancer patients admitted to our hospital from January 2015 to October 2017 were selected as the research object,and randomly divided into control group (perioperative routine nursing)and experimental group(perioperative comfortable nursing),30 cases in each group.The incidence of postoperative complications,quality of life and nursing satisfaction were observed and compared between the two groups.
Results
The incidence of complications in the control group was significantly higher than that in the experimental group,and the difference was statistically significant(P＜0.05).The nursing satisfaction of the control group was significantly lower than that of the experimental group,and the difference was statistically significant(P＜0.05).The scores of SCL-90([46.4±5.3]points)in the experimental group were significantly lower than those in the control group([69.2±3.7]points),the difference was statistically significant(t=19.3201,P=0.0000).
Conclusion
The application of comfortable nursing in perioperative nursing of patients with breast cancer is beneficial to prevent and reduce postoperative complications and improve the effect of operation.It is worthy of clinical selection and popularization.
2018 Vol. 25 (12): 195-197 [
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134
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