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| Effects of Dexmedetomidine in different doses on sedation and analgesia in elderly patients with arthroplasty |
| ZHOU Wu-zhao HU Qin-qing LI Hong-qing |
| Department of Anesthesiology,the Second People′s Hospital of Shantou City,Guangdong Province,Shantou 515011,China |
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Abstract Objective To compare the sedative and analgesic effects of Dexmedetomidine in different doses in elderly patients with arthroplasty.Methods A total of 84 elderly patients who underwent arthroplasty in our hospital from April to October in 2017 were divided into three groups according to the stratified randomized method.In combination group(n=28),low loading and maintenance doses of Dexmedetomidine was used.In maintenance group(n=28),a small dose of Dexmedetomidine for maintenance was selected.In the control group(n=28),intravenous infusion of saline was adopted.The sedative and analgesic effects among the three groups were compared.Results In both combination and maintenance groups,the sedation scores after medication and 30 min after medication were lower than those in the control group with statistical differences(P<0.05).In the combination group,the sedation scores after medication and 30 min after medication were lower than those after anesthesia,and the sedation score 30 min after treatment were lower than that just after medication(P<0.05).In the maintenance group,the sedation scores after medication and 30 min after treatment were both lower compared with those after anesthesia,which displayed statistical differences(P<0.05).In both combination and maintenance groups,the VAS analgesia scores after medication and 30 min after treatment were significantly lower than those in the control group(P<0.05).Meanwhile,they were all also lower than those after anesthesia(P<0.05).The scores of VAS analgesia 30 min after medication in the combination and maintenance group were lower than those just after medication(P<0.05).In the control group,the VAS analgesia score 30 min after medication was lower in comparison with that after anesthesia with a statistical difference (P<0.05).Conclusion Low-dose Dexmedetomidine in a continuous pump injection for sedation and analgesia in elderly patients with joint replacement can obtain a remarkable effect and is one of the appropriate surgical anesthesia methods.
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