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2019 Vol. 26, No. 2
Published: 2019-01-18

 
 
4 Influencing factors of acute ischemic stroke
WU Mei-ting;CHEN Ci-yu;WANG Si-ping;SHEN Bin-yan;WANG Juan
Objective To investigate the influencing factors of the onset of acute ischemic stroke.Methods A 1∶1 case-control study was conducted among 694 patients hospitalized in the First Affiliated Hospital of Guangdong Pharmaceutical University from September 2016 to October 2017.Logistic regression was used to analyze the factors affecting the onset of acute ischemic stroke.Results The results of univariate analysis on the incidence of acute is chemic stroke suggest that,the years of education,monthly income,birth place,current place of residence,occupation,smoking,exercise,high salt,high sugar,high fat,eggs,lean meat,poultry,vegetables,coarse grains,tea drinking,hypertension,diabetes,coronary heart disease,hyperlipidemia,atrial fibrillation,stroke history,white blood cells(WBC),fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),systolic blood pressure(SBP),diastolic blood pressure(DBP)and body mass index(BMI)in case group were compared with those in control group,and the differences were statistically significant(P<0.05).Multivariate unconditioned Logistic analysis showed that the risk factors of ischemic stroke were education years,smoking,high salt,high fat,eggs,hypertension,atrial fibrillation,stroke history,LDL-C,TG and SBP,and the protective factors were exercise and tea drinking (P<0.05).Conclusion Active control of risk factors for stroke can help reduce the incidence of ischemic stroke.
2019 Vol. 26 (2): 4-7 [Abstract] ( 110 ) HTML (37 KB)  PDF  (0 KB)  ( 13 )
8 Meta analysis of TLR2 Arg753Gln and CD14-159C/T polymorphisms and susceptibility to Streptococcus pneumoniae disease
ZHU Man-gui;FENG Yan;LI Xia-xi
Objective To investigate the association between TLR2 Arg753Gln and CD14-159C/T polymorphisms and Streptococcus pneumoniae disease.MethodsPubmed,embase,Cohrance,CNKI,VIP,Wanfang Data were searched to get related clinical controlled trials.The time limit for retrieving studies was until June 1,2017.Meta-analysis was conducted by Revman 5.3 software.Results Three TLR2 related papers were included,with a total sample size of 951 cases.Two CD14 related studies were included,with a total sample size of 674 cases.Meta-analysis showed no correlation between Arg753Gln polymorphism of TLR2 gene and CD14-159C/T polymorphism and susceptibility to Streptococcus pneumoniae disease(dominant allele vs.recessive alleles:OR=0.76,95%CI=0.40-1.46,P=0.41;dominant genotype vs.recessive genotype:OR=0.70,95%CI=0.34-1.44,P=0.33).Conclusion No significant differences between TLR2 Arg753Gln and CD14-159C/T polymorphisms and Streptococcus pneumoniae disease were found in the metaanalysis.
2019 Vol. 26 (2): 8-11 [Abstract] ( 112 ) HTML (35 KB)  PDF  (0 KB)  ( 17 )
12 Risk factors in delirium patients with acute coronary syndrome after percutaneous coronary intervention:A Meta-Analysis
MA Jing-ru;WANG Zhan-sheng;ZHANG Xiao-nan;FAN Meng-meng
Objective To evaluate the main risk factors for delirium after percutaneous coronary intervention (PCI)in patients with acute coronary syndrome (ACS),to analyze the association between risk factors and delirium.Methods A case-control study of major risk factors for delirium in patients with ACS after PCI were retrieved from the database and Meta-analysis was performed using RevMan 5.2 software.Results Finally,9 studies and 384 patients were included.Meta analysis showed that the age of delirium group and control group (OR=5.53,95%CI[2.28,13.42],P=0.0002),previous history of cerebrovascular disease [OR=10.56,95%CI[5.19,21.48],P<0.00001],atrial fibrillation[OR=3.31,95%CI[1.84,5.97],P<0.0001],anemia [OR=2.65,95%CI[1.55,4.53],P=0.0004],the increase of serum creatinine[OR=13.09,95%CI[5.15,33.30],P<0.00001],and the high dosage of contrast agent[OR=5.56,95%CI[1.32,23.37],P=0.002]had significant difference.Conclusion The current evidence shows that age,past history of cerebrovascular disease,atrial fibrillation,anemia,elevated serum creatinine,and large dosage of contrast agents are the main risk factors for delirium in patients with ACS after PCI.But this conclusion still needs further high-quality prospective study.
2019 Vol. 26 (2): 12-16 [Abstract] ( 111 ) HTML (38 KB)  PDF  (0 KB)  ( 15 )
17 Comparison of the application effects of Hem-o-lok and appendix transfixion and purse suture ligation in the treatment of appendix stump by laparoscopic appendectomy
LIANG Yong-sheng;GUAN Jian-xin;CHEN Zhen-huan
Objective To compare the clinical effects of Hem-o-lok ligature clamp clamping and appendix stump suture and purse embedding in appendix stump by laparoscopic appendectomy.Methods A total of 100 cases of appendicitis patients who underwent laparoscopic appendectomy in our hospital from January 2016 to January 2018 were selected as the research objects.Patients were randomly divided into 2 groups by random number table method,50 cases in each group.The appendix stump was clamped with Hem-o-lok ligature clamp was used in laparoscopic appendectomy for patients in the clamping group,and Hem-o-lok ligation clip was used in patients in the purse suture group for clamping appendectomy the appendix stump was sutured,purse was sutured and embedded was used in laparoscopic appendectomy for patients in the purse suture group.The operation condition,postoperative pain score,postoperative complications,postoperative recovery,and immune function index were compared between the two groups.Results In terms of the surgery,the surgery time in the purse suture group was longer than that in the clamping group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the amount of intraoperative blood loss between the two groups(P>0.05).In terms of postoperative pain scores,there were no statistically significant differences in pain scores between the two groups at 8,12,24,and 48 h after surgery (P>0.05).In terms of postoperative complications,the total incidence of postoperative complications of purse suture group was 4.00%,and the to-tal incidence of postoperative complications in the clamping group was 18.00%.The total incidence of postoperative complications of postoperative complications in the purse suture group was lower than that in the clamping group,the difference was statistically significant(P<0.05).In terms of postoperative recovery,the anal exhaust recovery time and length of hospital stay in the purse suture group were both shorter than those in the clamping group,the differences were statistically significant(P<0.05).In terms of immune function indexes,the CD3+,CD4/CD8 of the two groups after surgery were lower than those before surgery,the differences were statistically significant(P<0.05),and the CD3+,CD4/CD8 in the purse suture group were higher than that in the clamping group,the differences were statistically significant(P<0.05).Conclusion In laparoscopic appendectomy,Hem-o-lok ligature clamping and purse suture embedding can effectively treat the appendix stump,which has their own advantages.The surgery time of the Hem-o-lok ligature clamping is relatively short and easy to operate.The postoperative complications of purse suture embedding are less,and the postoperative recovery is faster.Clinically,the corresponding appendix stump treatment method can be reasonably selected according to the specific needs of the patient.
2019 Vol. 26 (2): 17-20 [Abstract] ( 119 ) HTML (40 KB)  PDF  (0 KB)  ( 17 )
21 Effect of acupuncture combined with conventional drugs on ankylosing spondylitis
LIU Bi-yan
Objective To investigate the effect of acupuncture combined with conventional drugs on ankylosing spondylitis.Methods A total of 80 patients with ankylosing spondylitis admitted to our hospital from January 2016 to January 2018 were selected as the study subjects,and they were randomly divided into 40 cases of the control group and 40 cases of the observation group according to different treatment methods.The patients in the control group were treated with oral Diclofenac Sodium and Sulfasalazine,and the observation group was given acupuncture treatment on the basis of the control group.All the patients had been treated for 2 courses,30 d for a course.Before and after treatment,two groups of patients were evaluated for TCM symptoms,the thoracic activity and spinal activity were measured,the bath ankylosing spondylitis disease activity index(BASDAI)and bath ankylosing spondylitis function index(BASFI)were evaluated.Quality of life improvement was assessed by SF-36 quality of life scale,C-reactive protein(CRP)was detected by ELISA,and tumor necrosis factor(TNF-α)was detected by radioimmunoassay.Adverse reactions in both groups were recorded.Results The scores of TCM symptoms such as lumbosacral pain,low back pain and morning stiffness after treatment in the control group and the observation group were significantly lower than those before treatment,the differences were statistically significant(P<0.05),the thoracic activity and spinal activity were significantly higher than before treatment,the differences were statistically significant(P<0.05).The scores of TCM symptoms such as lumbosacral pain,low back pain and morning stiffness in the observation group after treatment were significantly lower than the control group,the differences were statistically significant(P<0.05),the thoracic activity and spinal activity were significantly higher than the control group,the differences were statistically significant(P<0.05).The BASDAI index,BASFI index,CRP and TNF-α after treatment in the control group and the observation group were significantly lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,the BASDAI index,BASFI index,CRP,TNF-α in the observation group were significantly lower than the control group,the differences were statistically significant(P<0.05).The scores of the SF-36 quality life scales in the control group and the observation group after treatment were significantly lower than those before treatment,the differences were statistically significant(P<0.05).The scores of the SF-36 quality of life scales in the observation group after treatment were significantly lower than the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Acupuncture can effectively relieve pain,improve thoracic activity,spinal activity,reduce inflammation,improve disease and quality of life,and has good safety in the treatment of ankylosing spondylitis.
2019 Vol. 26 (2): 21-24转33 [Abstract] ( 112 ) HTML (41 KB)  PDF  (0 KB)  ( 12 )
25 Correlation between MMP-9 and airway remodeling in bronchial asthma and its clinical application
YE Hong-wei;LIANG Min-yong;WANG Xiao-li;WU Xiu-ming
The treatment of acute attack of bronchial asthma(asthma)is still based on its severity as an important reference and the severity of the disease was assessed by symptoms,signs,blood gas analysis and pulmonary function at onset in Guidelines for the prevention and treatment of bronchial asthma in China(2016).But there are certain limitations:the assessment of symptoms and signs is very subjective,and the prevalence of blood gas analysis and pulmonary function tests are not high in the primary hospital,and the pulmonary function tests are not practical in acute asthma attacks.Airway remodeling occurs early in the course of asthma and increases with the progression of the disease,which can reflect the severity of asthma.Matrix metalloproteinase-9(MMP-9)can be used as a biomarker for airway remodeling in asthma to assess asthma and airway remodeling.
2019 Vol. 26 (2): 25-28 [Abstract] ( 112 ) HTML (48 KB)  PDF  (0 KB)  ( 11 )
29 Research progress of LCZ 696 in the treatment of cardiovascular disease
CHENG Zhao;JIA Da-lin
Cardiovascular disease has become one of the serious diseases threatening human health.Although various drugs have been used for cardiovascular diseases,the morbidity and mortality are still high.Therefore,exploring new medicines is a hot spot in the treatment of cardiovascular diseases now.LCZ 696 is a novel neuroendocrine inhibitor with a dual inhibition of angiotensin receptor and nekephalin,and it is a cardiovascular drug with a new mechanism of action,which is considered to be one of the most important advances in the field of cardiovascular disease treatment in the past 10 years.This paper reviews the mechanism of action,the pharmacokinetics of LCZ 696 and the researches in the treatment of cardiovascular diseases.
2019 Vol. 26 (2): 29-33 [Abstract] ( 124 ) HTML (43 KB)  PDF  (0 KB)  ( 19 )
34 Influence of health education on improving dysphagia in patients with Alzheimer′s disease
YE Hua;YE Xiao-yun;LIU Min;GUO Yan
Objective To explore the Influence of health education on improving dysphagia in patients with Alzheimer′s disease.Methods A total of 40 patients with Alzheimer′s disease and dysphagia treated in Elderly Hospital of Guangzhou City from January 2016 to September 2017 were selected by randomized sampling method.All patients were given health education.After six months of health education,the dysphagia grading,BMI index of patients were observed.Results The improvement of dysphagia after patient care was better than that before nursing,and the difference was statistically significant(P<0.05).The average BMI after nursing was(22.45±3.54)kg/m2,which was higher than that before nursing for(20.69±2.28)kg/m2,and the difference was statistically significant(P<0.05).Conclusion Health education can help improve the dysphagia of patients with Alzheimer′s disease,which has higher application value,and is worthy of recommend.
2019 Vol. 26 (2): 34-36 [Abstract] ( 112 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
37 Effect comparison of the continuous nutritional support and nutritional support taken at a draught in critically ill patients
LIANG Rong-di
Objective To compare the effects of continuous nutritional support and nutritional support taken at a draught in critically ill patients.Methods Seventy critically ill patients admitted to our hospital from February 2017 to February 2018 were selected as subjects.They were divided into continuous group and draught group according to the randomization method,with 35 cases in each group.In the continuous group,continuous enteral nutrient solution for nutritional support was used,and in the draught group,enteral nutrition solution taken at a draught was adopted.The therapeutic effect of the two groups were compared.Results The pre-albumin (PA),hemoglobin (Hb)and albumin(ALB)in the continuous group were all higher than those in the draught group,with statistical significance (P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).There was no significant difference in the percentage of IgA,IgG,IgM or lymphocytes between the two groups(P>0.05).The duration of mechanical ventilation and the intensive care unit(ICU)stay in the continuous group were both shorter than those in the draught group,with significant differences (P<0.05).Conclusion For critically ill patients,continuous nutritional support is beneficial for patients′application status improvement,pstoperative hospital stay shortening,effective promotion for the recovery of the body,and non-increase of adverse reactions,which has a high application value.
2019 Vol. 26 (2): 37-39 [Abstract] ( 112 ) HTML (31 KB)  PDF  (0 KB)  ( 15 )
40 Evaluation of pathogenic characteristics and risk factors of nosocomial infection in patients with chronic renal failure
HOU Jing
Objective To analyze the pathogenic characteristics and risk factors of nosocomial infection in patients with chronic renal failure.Methods A total of 100 patients with chronic renal failure admitted to our hospital from May 2015 to January 2018 were selected as the subjects,and their clinical data were analyzed,including white blood cell count,serum albumin level,preventive use of antimicrobial agents,invasive procedures,complications,length of hospital stay,gender,age,etc.The related risk factors were evaluated.Results The types of infection in patients with chronic renal failure were mainly urinary tract infection,blood circulation system infection,catheter infection,digestive system infection,respiratory infection,etc.,and the probability of respiratory infection was significantly higher than those of the other types of infection (P<0.05).The results of pathogen isolation in patients with chronic renal failure were mainly Gram-negative bacteria,Gram-positive bacteria and fungi,and the proportion of Gram-negative bacteria was significantly higher than those of Gram-positive bacteria and fungi(P<0.05).Age≥60 years,hospital stay≥30 days,invasive procedure,combined complications,serum albumin level<35 g/L,white blood cell count<4×109/L were related factors of nosocomial infection in patients with renal failure (P<0.05).Hospital stay≥30 d,invasive procedure,serum albumin level<35 g/L,white blood cell count<4×109/L were independent risk factors of nosocomial infection in patients with renal failure (P<0.05).Conclusion There are many risk factors for nosocomial infection in patients with chronic renal failure.According to their specific infection characteristics,patients should be treated with antibiotics and relevant infection prevention measures should be implemented to control the occurrence of infection.
2019 Vol. 26 (2): 40-42转45 [Abstract] ( 95 ) HTML (32 KB)  PDF  (0 KB)  ( 15 )
43 Clinical effect of Budesonide,Ipratropium Bromide combined with Salbutamol in aerosol inhalation in the treatment of acute asthma attack
BAI Ying-lian;WAN Jun;MO Wen-qing;TANG Ying-lian;ZHANG Qi-song;SHAO Wei-ping
Objective To investigate the clinical effect of budesonide,ipratropium bromide combined with salbutamol in aerosol inhalation in the treatment of acute asthma attack.Methods Sixty patients with acute exacerbation of asthma admitted to our hospital from January 2015 to January 2017 were enrolled in the study.They were randomly divided into control group(n=32)and experimental group(n=28).In the control group,aerosol inhalation of budesonide and ipratropium bromide was used,while in the experimental group,salbutamol was added.The clinical therapeutic effect and the blood gas indexes before and after treatment compared between the two groups.Results The total effectiveness rate of the experimental group was 96.43%,which was higher than that of the control group accounting for 78.13%,with a significant difference (P<0.05).The PO2of the experimental group was higher than that of the control group,and PCO2 of the experimental group was lower than that of the control group,with statistical significance (P<0.05).Conclusion For patients with acute asthma attack,budesonide,ipratropium bromide combined with salbutamol in aerosol inhalation can obtain a remarkable clinical effect and significantly improve the blood gas index of patients.
2019 Vol. 26 (2): 43-45 [Abstract] ( 121 ) HTML (29 KB)  PDF  (0 KB)  ( 13 )
46 Clinical effect of rectal internal displacement flap repair in the treatment of high anal fistula
LI Zhen-wei
Objective To investigate the clinical effect of rectal internal displacement flap repair in the treatment of high anal fistula.Methods A total of 174 patients with high anal fistula who were admitted to Pu′ning Overseas Chinese Hospital from October 2017 to June 2018 were selected as the subjects.They were randomly divided into control group and treatment group,with 87 cases in each group.The treatment group was given rectal displacement flap for the repair of the internal orificium of anal fistula.The control group was given seton for treatment.The operation and postoperative recovery were compared between the two groups.The pain visual analogue scale (VAS)was used to compare the pain of the two groups on the 1st,3rd,and 7thdays after surgery,and the clinical effect was evaluated 3 months after surgery.The KELLY score was used to evaluate the anal function in both groups.Results The operation time in the treatment group was longer than that in the control group (P<0.05).There was no statistically significant difference in postoperative defecation time between the two groups(P>0.05).The healing time of anal fistula in the treatment group was shorter than that in the control group(P<0.05).The VAS scores in the treatment group were lower than those in the control group on the 1st,3rd,and 7thdays after surgery,and the differences were statistically significant(P<0.05).The cure rate and anal function scores in the treatment group were higher than those in the control group at 3 months after operation,and the differences were statistically significant(P<0.05).Conclusion Rectal internal displacement flap for the repair of orificium fistulae in the treatment of high anal fistula can reduce the healing time of anal fistula,relieve postoperative discomfort and improve curative effect,which has a good clinical effect.
2019 Vol. 26 (2): 46-48 [Abstract] ( 112 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
49 Effect of 3R health education on self-esteem and self-efficacy of patients with schizophrenia in community
LIU Lei;HUANG Hai-feng;JIANG Ting-yun
Objective To investigate the effect of 3R health education on self-esteem and self-efficacy of patients with chronic schizophrenia in the community.Methods A total of 116 patients with schizophrenia treated in the Third People′s Hospital of Zhongshan City from February 2013 to February 2015 were selected as study subjects.According to the random number table method,they were divided into the control group (58 cases)and the study group (58 cases).The control group was given regular follow-up education.The study group was further given 3R health education for 4 months continuously on the basis of routine follow-up education.The patient′s self-esteem level was evaluated with a self-esteem scale,and the patients′self-efficacy level was assessed with a general self-efficacy scale.Results Through 3R health education,the self-efficacy level in the study group was higher than that before education,and the difference was statistically significant(P<0.05).The scores of self-efficacy after education in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The self-esteem scores in the study group was significantly higher than that before education,and the difference was statistically significant(P<0.01).The self-esteem scores in the study group after education was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion 3R health education as a new way of health education can improve patients′self-confidence and self-esteem,enhance patients′self-efficacy and improve their quality of life.It is worthy of further application and promotion in the community′s severe mental illness management.
2019 Vol. 26 (2): 49-51 [Abstract] ( 113 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
52 Effect comparison of Aripiprazole and Risperidone in the treatment of schizophrenia
XUE Xin-jie;LAO Hui-shan ;WANG Yang;SUN Hong-bo;GUO Qin-qin
Objective To compare the effect of aripiprazole and risperidone in the treatment of schizophrenia.Methods A total of 120 patients with schizophrenia treated in our hospital from February 2016 to February 2017 were selected as the subjects.According to the random number table method,they were divided into group A and group B,with 60 cases in each group.In group A,patients were treated with aripiprazole,and in group B,patients were provided with risperidone.The clinical therapeutic effect of the two groups was compared.Results There were no statistical difference in the total effectiveness rate between the two groups (P>0.05).There were no statistical difference in the positive symptoms,negative symptoms,general psychopathology or total scores before treatment between the two groups (P>0.05).After treatment,scores of each index were lower compared with those before treatment(P<0.05).And there were no statistical difference in the positive symptoms,negative symptoms,general psychopathology or total scores after treatment between the two groups(P>0.05).The total incidence of adverse reactions in group A was 8.33%,which was lower than that of group B accounting for 18.33%,with a statistical difference (P<0.05).Conclusion Aripiprazole and risperidone both have certain value in the treatment of patients with schizophrenia.They can greatly alleviate the related symptoms and promote the stable condition.However,aripiprazole is safer which can effectively reduce the occurrence of adverse reactions,thus providing a guarantee for prognosis.
2019 Vol. 26 (2): 52-54 [Abstract] ( 122 ) HTML (30 KB)  PDF  (0 KB)  ( 14 )
55 Clinical effect of Alogliptin combined with Metformin in the treatment of type 2 diabetes mellitus complicated with non-alcoholic fatty liver
LIU Ying; YU Hong-ying
Objective To investigate the clinical effect of Alogliptin combined with Metformin in the treatment of type 2 diabetes mellitus complicated with non-alcoholic fatty liver(NAFLD).Methods A total of 60 patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver treated in our hospital from May 2017 to May 2018 were selectes as the subjects,and divided into observation group and control group by random number table method,with 30 cases in each group.The control group was treated with metformin.The observation group was treated with Aglutine combined with Metformin.The baric index(BMI),fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c),aspartate aminotransferase(AST),alanine aminotransferase(ALT),gamma-glutamyl transpeptidase(GGT),total cholesterol(TC),triacylglycerol(TG)and fatty liver clinical effects,adverse reactions were observed.Results BMI,FRG,2 hPG and HbAlc of the two groups after treatment were lower than those before treatment,and the BMI,FRG,2 hPG and HbAlc of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).AST,ALT,GGT,TC,TG of the two groups after treatment were lower than those before treatment,and the AST,ALT,GGT and TG of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in total incidence of adverse reactions between the two groups (P>0.05).Conclusion Agliptin combined with Metformin has obvious effect on type 2 diabetes mellitus complicated with NAFLD.It can effectively control blood glucose,improve liver function,and is safe.It is worthy of clinical application.
2019 Vol. 26 (2): 55-57 [Abstract] ( 96 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
58 Clinical effect of Self-formulated prescription Tangbikang in the treatment of qi deficiency and blood stasis in diabetic peripheral neuropathy
CHEN Xi-hui;ZHANG Yu-qin
Objective To explore the clinical effect of Tangbikang in the treatment of qi deficiency and blood stasis diabetic peripheral neuropathy.Methods A total of 80 patients with diabetic peripheral neuropathy treated in our hospital from October 2016 to March 2017 were selected as the subjects,and divided into two groups by random number table method.In the control group,patients were treated with the basic treatment combined with Mecobalanin Tablets,and in the observation group,patients were treated with Tangbikang based on the treatment of the control group.Both groups were given one course of treatment for 8 weeks.The clinical efficacy,TCSS scores,changes of nerve conduction velocity,and changes of hemorheology indexes between the two groups were compared.Results The total effective rate in the observation group was 87.5%,which was higher than in the control group(67.5%),the difference was statistically significant(P<0.05).After treatment,the TCSS scores of the two groups were lower than that before treatment,and the TCSS scores of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).After treatment,MNCV and SNCV of median nerve and peroneal nerve in the two groups were higher than those before treatment,and MNCV and SNCV in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Hemorheological indexes in the observation group after treatment were better than those before treatment and the control group,and the differences were statistically significant(P<0.05).Conclusion The efficacy of Self-designed Tangbikang is benefiting qi for activating blood circulation and dispersing blood stasis and dredging collateral,it can effectively treat the diabetic peripheral neuropathy,has the guiding significance to the clinic treatment,and it deserves the clinical promotion.
2019 Vol. 26 (2): 58-60 [Abstract] ( 124 ) HTML (35 KB)  PDF  (0 KB)  ( 15 )
61 Application effect of Carbon Nanoparticles Suspension Injection in lymph node dissection of thyroid cancer
DING Ji-wei;SHEN Wen-hua ;LIU Yan-zhang
Objective To observe the effect of Carbon Nanoparticles Suspension Injection in lymph node dissection of thyroid cancer.Methods A total of 60 patients with differentiated thyroid cancer admitted to our hospital from January 2015 to December 2017 were enrolled in the study.They were divided into the observation group and the control group according to the random number table method,with 30 cases in each group.The observation group injected 0.2 ml Carbon Nanoparticles Suspension Injection,while the control group injected 0.2 ml Methylthioninium Chloride Injection.Both groups was treated with total thyroidectomy and central lymph node dissection combined with lateral cervical lymph node dissection.The number of total detected lymph nodes,the number of lymph nodes detected in each case,the number of stained lymph nodes detected,the number of lymph nodes for diameter<2 mm,the positive rate of lymph node metastases,the number of metastatic lymph nodes detected,the number of stained metastatic lymph nodes detected,the parathyroid error rate,the total incidence of postoperative complications were compared between two groups.Results The total number of lymph nodes,the number of lymph nodes detected in each case,the number of stained lymph nodes detected,the number of lymph nodes for diameter<2 mm,number of metastatic lymph nodes detected and the number of stained metastatic lymph nodes detected in the observation group were significantly higher than those in the control group (P<0.05).There were no significant difference in the positive rate of lymph node metastases,the parathyroid error rate between the two groups(P>0.05),and the total incidence of postoperative complications in the observation group was 10.00%,which was significantly lower than 30.00%of the control group (P<0.05).Conclusion The application of Carbon Nanoparticles Suspension Injection in thyroid cancer surgery can help to understand the situation of lymph nodes,improve the accuracy of lymph node dissection,effectively protect parathyroid glands,reduce complications and medical disputes.
2019 Vol. 26 (2): 61-63转67 [Abstract] ( 112 ) HTML (36 KB)  PDF  (0 KB)  ( 15 )
64 Clinical effect of Gefitinib in the treatment of patients with non-small cell lung cancer
HUANG Chao;JIN E ;TIAN Hong
Objective To investigate the clinical effect of Gefitinib in the treatment of patients with non-small cell lung cancer(NSCLC).Methods A total of 80 patients with NSCLC admitted to our hospital from March 2015 to May 2016 were enrolled in this study.They were divided into the control group and the the observation group according to a random number table method,40 cases in each group.The control group was treated with GP regimen,Gemcitabine combined with Cisplatin regimen,while the observation group was treated with Gefitinib.The epidermal growth factor receptor(EGFR)mutations in the two groups were compared.The keratin 19(CYFRA 21-1)and carcinoembryonic antigen(CEA)levels after treatment,and median survival time,quality of life,and therapeutic effect of the two groups were compared.Results The mutation rate of the observation group was significantly lower than that of the control group(P<0.05).The levels of CYFRA 21-1 and CEA in the observation group were lower than those of the control group (P<0.05).The survival time of the observation group was longer than that of the control group(P<0.05).The 1-year and 2-year survival rates of the observation group were both higher than those of the control group(P<0.05).The effectiveness rate of disease treatment in the observation group was significantly higher compared with that of the control group (P<0.05).Conclusion In NSCLC patients with markedly elevated CEA and CYFRA 21-1 levels,Gefitinib treatment can effectively reduce EGFR mutation rate,reduce tumor marker levels,prolong patient′s survival time,and improve the clinical therapeutic effect.
2019 Vol. 26 (2): 64-67 [Abstract] ( 101 ) HTML (34 KB)  PDF  (0 KB)  ( 18 )
68 Effect of time-modulated induction chemotherapy combined with intensity-modulated radiotherapy plus concurrent Lobaplatin chemotherapy in the treatment of locally advanced head and neck squamous cell carcinoma
GUO Li-yi;DENG Ming-hui;LYU Li
Objective To investigate the clinical effect of combined time-modulated induction chemotherapy and intensity-modulated radiotherapy with concurrent lobaplatin chemotherapy in locally advanced head and neck squamous cell carcinoma.Methods Altogether 60 patients with locally advanced head and neck squamous cell carcinoma from April 2014 to April 2017 were selected and randomly divided into the observation group and the control group,30 cases in each group.The control group was treated with time-modulated induction chemotherapy.The observation group was treated with time-modulated induction chemotherapy and intensity-modulated radiotherapy combined with concurrent Lobaplatin chemotherapy.The incidence of adverse reactions,total effective rate,one-year overall survival rate,progression-free survival rate and local recurrence-free survival rate were compared between the two groups.Results The total effective rate of the observation group was 60.00%,which was higher than that of the control group(30.00%),with statistically significant difference (P<0.05).The total incidence of adverse reactions of the observation group was 23.33%,compared with the control group(20.00%),there was no statistically significant difference(P>0.05).The oneyear overall survival rate,progression-free survival rate and local recurrence-free survival rate of the observation group were 80.00%,60.00%and 56.67%respectively,which was higher than those of the control group(53.33%,33.33%and 30.00%),with statistically significant difference (P<0.05).Conclusion Time-modulated induction chemotherapy combined with intensity-modulated radiotherapy combined plus concurrent Lobaplatin chemotherapy for locally advanced head and neck squamous cell carcinoma has a satisfactory effect with mild adverse reactions,which can be tolerated by patients and has clinical value.
2019 Vol. 26 (2): 68-70 [Abstract] ( 112 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
71 Effect comparison of laparoscopic and open surgery in the treatment of right colon tumor
LI Jian
Objective To compare the therapeutic effects of laparoscopic and open surgery in the treatment of right colon tumors.Methods A total of 98 patients with right colon cancer treated in our hospital from January 2011 to May 2013 were selected as the research objects.According to the different surgical methods,they were divided into the observation groups(n=50)and the control group(n=48).The control group received laparotomy,and the observation group received laparoscopic surgery.The operative-related indicators,the incidence rate of complications and 5-year survival rates were compared between the two groups.Results The operation time and hospitalization time of the observation group were shorter than those of the control group,and the amount of bleeding of the observation group was less than that of the control group,with significant difference(P<0.05).The exhaust time,out-of-bed activity time and liquid diet time of the observation group were shorter than those of the control group,with significant difference (P<0.05).The VAS score of the observation group was lower than that of the control group,with significant difference (P<0.05).The incidence rate of complication of the observation group was lower than that of the control group,and the 5-year survival rate of the observation group was higher than that of the control group,with significant difference(P<0.05).Conclusion Laparoscopic surgery is superior to open surgery in the treatment of right colon cancer.It is worthy of clinical popularization and application.
2019 Vol. 26 (2): 71-73 [Abstract] ( 124 ) HTML (30 KB)  PDF  (0 KB)  ( 12 )
74 Effect and safety of Pegaspargase in the treatment of extranodal NK/T-cell lymphoma
JIN Li;LI Zhao-hui;XU Ning; SONG Nan
Objective To investigate the effect and safety of Pegaspargase in the treatment of extranodal NK/T cell lymphoma.Methods A total of 60 patients admitted from January 2014 to December 2017 in Anshan Tumor Hospital were selected as the research objects.Patients were divided into the control group and the observation group by the random table method,30 cases in each group.The control group was treated with Gemcitabine,Oxaliplatin,Dexamethasone and L-asparaginase,while the observation group was treated with Gemcitabine,Oxaliplatin,Dexamethasone and Pegaspargase.The short-term curative efficacy and drug toxicity side effect were compared between the two groups.Results The total effective rate was 93.33%in the observation group and 90.00%in the control group,the difference was not statistically significant(P>0.05).The incidence of digestive tract reaction,hyperglycemia and allergic reaction in the observation group was significantly lower than that in the control group (P<0.05).There was no significant difference in the incidence of neutropenia,thrombocytopenia and hepatic dysfunction between the two groups(P>0.05).Conclusion Pegaspargase in the treatment of extranodal NK/T cell lymphoma is effective in the short term,with less side effect and high safety.It is worthy of clinical promotion.
2019 Vol. 26 (2): 74-76 [Abstract] ( 104 ) HTML (31 KB)  PDF  (0 KB)  ( 15 )
77 Influence of preoperative yellow reduction of bile duct on curative effect and prognosis of patients with hilar cholangiocarcinoma
LIU Yun-feng
Objective To investigate the influence of preoperative yellow reduction of bile duct on the curative effect and prognosis of hilar cholangiocarcinoma.Methods From March 2015 to March 2017,78 patients with hilar cholangiocarcinoma were selected and randomly divided into the experimental group and the reference group according to the order of treatment,with 39 patients in each group.The patients in the control group were treated with direct hepatectomy,the patients in the experimental group were treated with percutaneous transhepatic bile duct drainage before hepatectomy.The changes of liver function before and after treatment were observed in the experimental group,and the related indexes,postoperative complications and 1 year mortality were analyzed and compared between the two groups.Results The liver function indexes such as TB,ALT,γ-GT and ALP in the experimental group after treatment were all lower than those before treatment,the difference was statistically significant(P<0.05).There was no significant difference in operative time,hospitalization time and blood transfusion volume between the two groups (P>0.05),the amount of intraoperative blood loss in the experimental group was less than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in postoperative complications and 1-year mortality between the two groups (P>0.05).Conclusion Preoperative yellow reduction of bile duct can effectively improve liver function of patients with hilar cholangiocarcinoma,but it can not significantly reduce postoperative complications and mortality.Patients with poor preoperative liver function can be treated with selective yellow reduction.
2019 Vol. 26 (2): 77-79 [Abstract] ( 105 ) HTML (31 KB)  PDF  (0 KB)  ( 15 )
80 Clinical effect of Thymosin α1in the treatment of digestive system tumors in elderly patients
1in the treatment of digestive system tumors in elderly patients[J]. 中国当代医药, 2019,26(2): 80-82')" href="#"> FAN Ming-juan
Objective To study the clinical effect of Thymosin α1in the treatment of digestive system tumors in elderly patients.Methods A total of 100 elderly patients with digestive system tumors from August 2016 to December 2017 in our hospital were selected as research objects and they were divided into the control group and the observation group according to the computer randomization,with 50 cases in each group.The control group was treated with conventional chemotherapy,and the observation group was treated with Thymosin α1.The immune function,Karnofsky scores before and after treatment and total effectiveness rate were compared between the two groups.Results The levels of CD3+,CD4+,CD8+,CD4+/CD8+,NK lymphocyte in the two groups after treatment were better than those before treatment,with statistically significant differences(P<0.05).The levels of CD3+,CD4+,CD8+,CD4+/CD8+,NK lymphocyte in the observation group after treatment were better than those in the control group,with statistically significant differences(P<0.05).The total effective rate of the observation group was higher than that of the control group,with statistically significant difference(P<0.05).The Karnofsky scores of the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).The Karnofsky score of the observation group after treatment was higher than that of the control group,with statistically significant difference (P<0.05).Conclusion Thymosin α1has a significant effect on treating digestive system tumors in elderly patients,which can improve immune function of patients with high safety and it is worthy of further study.
2019 Vol. 26 (2): 80-82 [Abstract] ( 110 ) HTML (37 KB)  PDF  (0 KB)  ( 13 )
83 Clinical effect of minimally invasive intervention in the comprehensive treatment of malignant tumors
LI Tao;CUI Jian-dong;LONG Gui-ning;WEN Shi-long;WANG Hong-zhi
Objective To study the clinical effect of minimally invasive intervention in the comprehensive treatment of malignant tumors.Methods A total of 60 cases of patients with malignant tumor from July 2016 to July 2018 treated in our hospital were selected as study objects.They were randomly divided into the minimally invasive interventional therapy group(30 cases)and the traditional chemotherapy group(30 cases).The minimally invasive interventional therapy group was given minimally invasive interventional therapy,while the traditional chemotherapy group was given routine chemotherapy.The improvement of clinical symptoms,white blood cell counts,Karnofsky(KPS)scores and clinical effect of the two groups were statistically analyzed.Results The improvement rates of nausea,vomiting,loss of appetite,fatigue,fatigue and pain of the minimally invasive interventional therapy group were significantly higher than those of the traditional chemotherapy group,and the differences were statistically significant(P<0.05).The white blood cell counts and KPS score after treatment in the minimally invasive interventional therapy group were significantly higher than those in the traditional chemotherapy group,and the differences were statistically significant(P<0.05).The total remission rate of the minimally invasive interventional therapy group was significantly higher than those of the traditional chemotherapy group,and the difference was statistically significant(P<0.05).Conclusion The clinical effect of minimally invasive intervention is better than that of traditional chemotherapy in the comprehensive treatment of malignant tumors.
2019 Vol. 26 (2): 83-85 [Abstract] ( 104 ) HTML (31 KB)  PDF  (0 KB)  ( 16 )
86 Clinical effect of concurrent chemoradiotherapy in the treatment of advanced non-small cell lung cancer
RAO Jing-jie;WU Xi-shi;ZHU Hui;YANG Jian;WANG Hui-min;HONG Dao-zhong
Objective To investigate the clinical effects of concurrent chemoradiotherapy in the treatment of advanced non-small cell lung cancer.Methods A total of 100 patients with advanced non-small cell lung cancer from January 2016 to January 2018 in the department of oncology in our hospital were selected as research subjects.According to the method of remote randomization,all the patients were divided into the control group and the experimental group,50 cases in each group.The control group was given sequential chemotherapy and radiotherapy.The experimental group was given concurrent chemoradiotherapy.The therapeutic efficacy,the incidence of adverse reactions and quality of life of patients with advanced non-small cell lung cancer were compared between the two groups.Results The total effective rate of treatment in the patients with advanced non-small cell lung cancer in the experimental group was 66.00%,which was significantly higher than 42.00%in the control group,the difference was statistically significant(P<0.05).The incidence rate and severity of adverse reactions such as leukopenia,radiation esophagitis,and radiation-induced lung injury in the experimental group were compared with the control group,and the differences were not statistically significant(P>0.05).The quality of life scores in the experimental group after treatment were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Patients with advanced non-small cell lung cancer receive concurrent chemoradiotherapy has a good therapeutic effect.It has a positive significance for improving the quality of life and extending life expectancy.
2019 Vol. 26 (2): 86-88 [Abstract] ( 70 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
89 Application effect of addition and subtraction of Guizhi Fuling Pill in lung cancer surgery
ZHANG Shu-cheng
Objective To investigate the application effect of addition and subtraction of Guizhi Fuling Pill in lung cancer surgery.Methods A total of 106 patients with lung cancer admitted to our hospital from March 2016 to May 2017 were selected as research targets.According to different admission time,they were divided into the control group and the treatment group,53 cases in each group.The control group underwent radical lung cancer surgery.The treatment group underwent radical lung cancer surgery on the basis of oral Guizhi Fuling Pill.The difference between the clinical efficacy of the two groups and the incidence rate of adverse reactions during chemotherapy was compared.Results The total effective rate of the treatment group was significantly higher than that of the control group,and the incidence rate of adverse reactions during chemotherapy in the treatment group was significantly lower than that in the control group,with significant difference (P<0.05).Conclusion The addition and subtraction of Guizhi Fuling Pill can further improve the clinical efficacy of radical mastectomy and reduce the incidence of adverse reactions during chemotherapy.It has clinical use and promotion value.
2019 Vol. 26 (2): 89-91 [Abstract] ( 101 ) HTML (29 KB)  PDF  (0 KB)  ( 15 )
92 Effect of thoracoscopic radical resection of lung cancer in the treatment of early stage non-small cell lung cancer
ZHU Jun;DUAN Hai-rui;YUAN Quan
Objective To explore the clinical effect of thoracoscopic radical resection of lung cancer in the treatment of early stage non-small cell lung cancer.Methods A total of 110 cases of early stage non-small cell lung cancer patients were selected from January 2012 to March 2017 in our hospital.According to the different treatment methods,they were divided into the thoracotomy group and the thoracoscopy group,55 cases in each group.Traditional thoracotomy was used in the thoracotomy group,while thoracoscopic radical resection of lung cancer was used in the thoracoscopy group.The success rate,operation time,indwelling drainage tube time,blood transfusion volume,total drainage volume,number and amount of lymph node dissection group and the incidence of complications were compared between the two groups.Results There was no significant difference in the success rate between the thoracotomy group and the thoracoscopy group (P>0.05).The operation time and indwelling drainage tube time of the thoracoscopy group were shorter than those of the thoracotomy group,and the amount of blood transfusion and total drainage of the thoracoscopy group were less than those of the thoracotomy group (P<0.05).There was no significant difference in the number and volume of lymph node dissection between the two groups(P>0.05).The total incidence of complications in the thoracoscopy group was lower than that in thoracotomy group(P<0.05).Conclusion The curative effect of thoracoscopic radical resection of lung cancer for patients with early stage non-small cell lung cancer is accurate.It can effectively improve the patient′s condition,shorten the time of operation and drainage tube indwelling,reduce the volume of flow and bleeding,and reduce the incidence of complications.It is worth popularizing.
2019 Vol. 26 (2): 92-94 [Abstract] ( 88 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
95 Effect comparison of laparoscope-assisted and laparotomy D2radical operation for stomach cancer in the treatment of advanced stomach cancer
2radical operation for stomach cancer in the treatment of advanced stomach cancer[J]. 中国当代医药, 2019,26(2): 95-97')" href="#"> YAO Yong-sheng;CHEN Xiao-feng;LIN Geng-liang
Objective To compare the differences between laparoscope-assisted and laparotomy D2radical operation for stomach cancer in the treatment of advanced stomach cancer.Methods A total of 38 patients were systematically reviewed who were diagnosed in the First Department of Surgery of our hospital from March 2014 to March 2015,all cases of gastric cancer were divided into the experimental group and the control group according to the different surgical methods,19 cases in each group.The experimental group adopted laparoscope-assisted D2radical operation for stomach cancer,while the control group was treated with laparotomy D2radical operation for stomach cancer.The operation time,bleeding volume,abdominal drainage volume,exhaust time and hospitalization time were observed and compared between the two groups.After 3 years′follow-up visit,the postoperative long-term survival rate was analyzed.Results The average operation time of the experimental group was significantly longer than that of the control group,the intraoperative bleeding volume and abdominal drainage volume in the experimental group were significantly less than those in the control group,the exhaust time and hospitalization time in the experimental group were significantly shorter than those in the control group,with significant difference (P<0.05).The total incidence of adverse reactions and mortality rate of the experimental group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of laparoscope-assisted D2radical operation for stomach cancer in the treatment of advanced stomach cancer is significant and it is worthy of clinical promotion.
2019 Vol. 26 (2): 95-97 [Abstract] ( 93 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
98 Clinical effect of moxibustion combined with Montmorillonite Powder and Bifidobacterium Triple Live Bacteria Powder in the treatment of children with rotavirus enteritis
LIU Qi
Objective To investigate the clinical effect of moxibustion combined with Montmorillonite Powder and Bifidobacterium Triple Live Bacteria Powder in the treatment of children with rotavirus enteritis.Methods A total of 116 cases of children with rotavirus enteritis admitted to our hospital from January 2016 to May 2018 were selected as research objects.They were divided into the control group(58 cases)and the treatment group(58 cases)according to the random even/odd method.The control group was treated with Montmorillonite Powder and Bifidobacterium Triple Live Bacteria Powder alone,and the treatment group was treated with moxibustion combined with Montmorillonite Powder and Bifidobacterium Triple Live Bacteria Powder.The clinical treatment effect and the disappearance time of clinical symptoms were compared between the two groups.Results The total effective rate of treatment in the treatment group was 96.6%,which was significantly higher than that in the control group accounting for 82.8%,and the difference was statistically significant(P<0.05).The antiemetic time and antidiarrhea time of the treatment group were significantly shorter than those of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the disappearance time of dehydration symptom between the two groups(P>0.05).Conclusion Moxibustion combined with Montmorillonite Powder and Bifidobacterium Triple Live Bacteria Powder has a good effect in the treatment of children with rotavirus enteritis,which can effectively promote the recovery of the disease,with clinical application and reference significance.
2019 Vol. 26 (2): 98-100 [Abstract] ( 121 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
101 Effect of lymphatic vessels on the formation of pelvic lymphocyst after ligation of methylene blue staining
HU Ping;PENG Wei;WU Ming-tao;LIU Ting;WANG Wen-hua
Objective To analyze the effect of lymphatic vessels on the formation of pelvic lymphocyst after ligation of methylene blue staining.Methods A total of 86 patients with gynecologic malignancies who underwent pelvic lymphadenectomy from January 2017 to June 2018 were selected as research objects,and the patients were divided into the study group and the control group according to the random number table method,with 43 cases in each group.Patients in the study group underwent methylene blue to trace the lymphatic vessels and then the pelvic lymphatic vessels were ligated,and the pelvic lymphatic vessels were routinely ligated in the control group.The pelvic lymphocyst formation and complications (wound infection,fever,deep vein thrombosis,intestinal obstruction,perineal swelling)were compared between the two groups at different time points,and the incidence of methylene blue adverse reactions in the study group was observed.Results The incidence rates of pelvic lymphocysts at 1 week and 4 weeks after operation in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence rates of pelvic lymphocysts at 12 and 24 weeks after operation in the study group were lower than those in the control group,but the differences weren′t statistically significant(P<0.05).The total incidence rate of postoperative complications in the study group was lower than that in the control group,but the difference was not statistically significant(P>0.05).In the study group,no adverse reactions such as dizziness,vomiting,chest tightness,infection,and blood pressure were observed after the injection of Methylene Blue Injection.Conclusion Lymphatic vessels after ligation of methylene blue staining can reduce the incidence of pelvic lymphocyst,and at the same time it can reduce adverse reactions,which is worthy of clinical promotion and application.
2019 Vol. 26 (2): 101-103转116 [Abstract] ( 83 ) HTML (33 KB)  PDF  (0 KB)  ( 18 )
104 Application effect of Pituitrin+Quill barbed thread+baseball suture in laparoscopic uterine myomectomy
WAN He-ping;HAN Hui-jun
Objective To investigate the application effect of Pituitrin+Quill barbed thread+baseball suture in laparoscopic uterine myomectomy.Methods Altogether 92 patients who underwent laparoscopic uterine myomectomy in our hospital from October 2015 to October 2017 were selected as research objects and they were randomly divided into the control group and the treatment group,with 46 cases in each group.The control group was treated with Pituitrin+conventional microtrellis thread+traditional suture method,and the treatment group was treated with Pituitrin+Quill barbed thread+baseball suture method.The intraoperative bleeding volume,postoperative pelvic drainage volume,complications,total operation time,tumor cavity and wound suture time,postoperative drainage time,postoperative hospitalization time,and satisfaction with the surgical hemostasis program of patients were compared between the two groups.Results The intraoperative bleeding volume and postoperative pelvic drainage volume in the treatment group were less than those in the control group,and the differences were statistically significant(P<0.05).The rate of complications in the treatment group was 4.3%(2/46),which was lower than that in the control group accounting for 21.7%(10/46),and the difference was statistically significant(P<0.05).The total operation time,tumor cavity and wound suture time,postoperative drainage time and postoperative hospitalization time were shorter than those in the control group,and the differences were statistically significant(P<0.05).The total satisfaction rate of the surgical hemostasis program was 93.5%in the treatment group,which was higher than that in the control group(78.3%),and the difference was statistically significant(P<0.05).Conclusion Pituitrin+Quill barbed thread+baseball suture in the treatment of laparoscopic uterine myomectomy can reduce the amount of bleeding during operation and postoperative pelvic drainage,shorten the operation time and postoperative recovery time,reduce the rate of complications and improve satisfaction of patients.
2019 Vol. 26 (2): 104-106 [Abstract] ( 95 ) HTML (33 KB)  PDF  (0 KB)  ( 14 )
107 Clinical effect of Salbutamol Sulfate Solution combined with Budesonide Suspension aerosol inhalation in the treatment of children with bronchial asthma complicated with pneumonia
YU Zhi-xin;XIE Xiao-qin
Objective To investigate the clinical effect of Salbutamol Sulfate Solution combined with Budesonide Suspension aerosol inhalation in the treatment of children with bronchial asthma complicated with pneumonia.Methods Altogether 72 cases of children with bronchial asthma complicated with pneumonia who were treated in our hospital from January 2015 to December 2017 were selected as the research subjects,and they were randomly divided into the observation group and the control group,with 36 cases in each group.The observation group was treated with Salbutamol Sulfate Solution and Budesonide Suspension aerosol inhalation,while the control group was treated with Budesonide Suspension aerosol inhalation.The clinical treatment effect,recurrence and changes of lung function (1 second forced expiratory volume [FEV1],FEV1proportion)before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.4%,which was significantly higher than that in the control group(86.1%),and the difference was statistically significant(P<0.05).There were no significant differences in the FEV1and proportion of FEV1between the two groups before treatment(P>0.05).The FEV1and proportion of FEV1in the two groups after treatment were significantly higher than those before treatment,and the differences were statistically significant(P<0.05).The FEV1and proportion of FEV1in the observation group after treatment were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The recurrence rate of the observation group was 5.6%(2/36),which was significantly lower than that of the control group accounting for 22.2%(8/36),and the difference was statistically significant(P<0.05).Conclusion The effect of Salbutamol Sulfate Solution combined with Budesonide Suspension aerosol inhalation is certain in the treatment of children with bronchial asthma complicated with pneumonia,and it can significantly change the clinical symptoms,with lower recurrence rate,which is worthy of clinical application.
2019 Vol. 26 (2): 107-109 [Abstract] ( 83 ) HTML (35 KB)  PDF  (0 KB)  ( 14 )
110 Effect of intake management during labor on delivery outcomes
PAN Li-li;HUANG Li-chuan ;YAO Juan; HUANG Zhong-yang;RAO Wen-yu
Objective To assess the effect of intake management during labor on delivery outcomes.Methods A total of 150 single-term full-term primipara who gave birth in our hospital from February to July 2018 were selected as research objects and they were divided into oral administration group,intravenous administration group and control group according to the voluntary principle,with 50 cases in each group."Pregnancy Jiabao"delivery energy package was orally administered in the oral administration group,physiological saline and 5%glucose solution alternately was given in the intravenous administration group during labor(after the uterine mouth opened 4 cm),and no additional oral administration and intravenous administration of energy was given in the control group during labor (after the uterine mouth opened 4 cm)except water.The second and third stage of labor time,total labor time,postpartum hemorrhage,neonatal score,and changes in blood sodium before and after delivery were compared among the three groups.Results The second and third stage of labor time and total labor time in the oral administration group were shorter than those in the intravenous administration group and control group,the second and third stage of labor time and total labor time in the intravenous administration group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in levels of blood sodium among the three groups before and after delivery (P>0.05).The postpartum 2 h hemorrhage volume in the oral administration group and intravenous administration group was lower than that in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the postpartum 2 h hemorrhage volume between the oral administration group and intravenous administration group (P>0.05).There were no statistically significant differences in the scores of the newborns among the three groups(P>0.05).Conclusion Intake management during the labor process(oral and intravenous administration)can achieve the purpose of accelerating labor and reducing postpartum hemorrhage,without affecting the changes of blood sodium,and has no effect on neonatal scores.The oral administration of"Pregnancy Jiabao"delivery energy package is more effective than the intravenous administration in shortening the labor process,and it is more convenient to use and is worthy of admiration.
2019 Vol. 26 (2): 110-112 [Abstract] ( 70 ) HTML (33 KB)  PDF  (0 KB)  ( 15 )
113 Analysis of the clinical diagnosis and treatment of residual horn uterine pregnancy
LU Jie;WANG Xiao-min
Objective To analyze the clinical features,diagnosis and treatment of residual horn uterine pregnancy,and to reduce the misdiagnosis rate.Methods The clinical data of 5013 cases with ectopic pregnancy admitted to our hospital from July 1,1993 to December 31,2016 were retrospectively analyzed,and the related literature was reviewed.Results During 23 years,10 cases of residual horn uterine pregnancy accounted for 0.20%of ectopic pregnancy patients at the same period,3 cases of residual horn uterine cavity connected with normal uterine cavity,7 cases of non-communicating residual horn uterus(70%).Four cases of intrauterine pregnancy were indicated by B-mode ultrasonography.Among them,2 cases had no villus after induced abortion,1 case had stillbirth after 3-month pregnancy clinic treatment,and 1 case had mid-pregnancy and intrauterine live fetus because of abdominal pain clinic B-mode ultrasonography.The other 6 cases were not examined and were first visited in our hospital.Among them,1 case was ruptured uterine remnant horn pregnancy,1 case was diagnosed uterine remnant horn pregnancy by ultrasound before rupture,accounting for 10%.3 cases were admitted to hospital with ectopic pregnancy,1 case had obvious anemia,shock and abdominal distension in 5 months of pregnancy,and the suspected intestinal obstruction was transferred to superior hospital.All the 10 patients underwent laparotomy,2 cases without rupture underwent elective operation,the remaining 8 cases underwent emergency operation,and 3 cases of fetus and placenta were discharged into abdominal cavity or blocked the rupture.The residual horn uterus was located on the right in 6 cases,on the left in 4 cases,on the opposite side of the corpus luteum in 3 cases,and on the umbrella end of the fallopian tube in 3 cases.Surgical methods included residual horn hysterectomy plus salpingectomy on the affected side in 5 cases,simple residual horn hysterectomy in 5 cases,and circular ligament suture and fixation in 3 cases.One patient died(10%).Conclusions Residual horn uterine pregnancy is very rare,often occurs in the second trimester of pregnancy uterine rupture,because there is no specific clinical manifestations,it is very easy to misdiagnose.Attention to early pregnancy examination,careful and accurate analysis of clinical data and ultrasound examination can help to reduce the rate of misdiagnosis;early operation should be carried out after diagnosis,and minimal invasive treatment should be advocated.
2019 Vol. 26 (2): 113-116 [Abstract] ( 95 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
117 Clinical effect of cervical dilatation balloon in the induction of labor in full-term pregnancy
HUANG Li-ping
Objective To analyze the clinical effect of cervical dilatation balloon in the induction of labor in full-term pregnancy.Methods From December 2016 to December 2017,a total of 50 full-term pregnant women who received nursing in our hospital were selected as subjects.The women were divided into control group and observation group according to the random number table method,with 25 cases in each group.Conventional Oxytocin for induction was used in the control group,while in the observation group,Oxytocin combined with cervical dilatation balloon was adopted.The total effective rate of cervical ripening,cesarean section rate,labor time and adverse reactions were compared between the two groups.Results The total effective rate of cervical ripening in the observation group was 92.00%,which was significantly higher than that of the control group(68.00%),and the difference was statistically significant(P<0.05).The cesarean section rate of the observation group was 12.00%,which was significantly lower than that of the control group(40.00%),and the difference was statistically significant(P<0.05).The first and second labor time and total labor time of the observation group were significantly shorter than those in the control group,and the differences were statistically significant (P<0.05).The total incidence rate of postpartum adverse reactions in the observation group was 8.00%,which was significantly lower than that in the control group(32.00%),and the difference was statistically significant(P<0.05).Conclusion In the induction of labor in full-term pregnancy,Oxytocin combined with cervical dilatation balloon can facilitate the cervical ripening,reduce the cesarean section rate and shorten the labor time compared with the application of Oxytocin alone,which is worthy of comprehensive promotion in the clinical practice.
2019 Vol. 26 (2): 117-119 [Abstract] ( 89 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
120 Analysis of the clinical effect of hysteroscopic tubal intubation and hydrotubation in the treatment of infertility
ZENG Shun-hua
Objective To analyze the clinical effect of hysteroscopic tubal intubation and hydrotubation in the treatment of infertility.Methods A total of 100 patients with infertility caused by tubal obstruction in our hospital from January 2015 to December 2016 were selected as the research objects,they were divided into observation group and control group according to different surgical method,with 50 cases in each group.The control group was given routine fallopian tubal intubation and hydrotubation,the observation group was given hysteroscopic tubal intubation and hydrotubation.The clinical efficacy and pregnancy rate of the two groups were compared after 1 year follow-up.Results The total effective rate of the observation group was significantly higher than that of the control group,the difference was significant(P<0.05).After one year of follow-up,the pregnancy rate of the observation group was 66.0%(33/50),higher than 42.0%(21/50)of the control group,the difference was statistically significant(P<0.05).Conclusion Hysteroscopy tubal intubation and hydrotubation has a good clinical effect in the treatment of infertility,and can improve the pregnancy rate of patients,which is worthy of clinical application.
2019 Vol. 26 (2): 120-122转126 [Abstract] ( 93 ) HTML (35 KB)  PDF  (0 KB)  ( 17 )
123 Effect of combined treatment of Labetalol and Magnesium Sulfate on pregnancy outcome in patients with preeclampsia
XIE Fang
Objective To investigate the effect of combined treatment of Labetalol and Magnesium Sulfate on pregnancy outcome in patients with preeclampsia.Methods Altogether 210 patients with preeclampsia admitted to our hospital from August 2016 to March 2018 were selected as research objects and they were divided into the combined group and basic group according to the random number table method,with 105 cases in each group.The patients in the basic group were treated with Magnesium Sulfate alone,and the patients in the combined group were treated with Labetalol and Magnesium Sulfate.The therapeutic effect,pregnancy outcomes,adverse reactions,and blood pressure and urine protein quantitation before and after treatment were compared between the two groups.Results There were no significant differences in blood pressure(diastolic blood pressure,systolic blood pressure)and 24 h urine protein quantitation between the two groups before treatment(P>0.05).The blood pressure and 24 h urine protein quantitation after treatment in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The blood pressure and 24 h urine protein quantitation after treatment in the combined group were lower than those in the basic group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the combined group was 96.2%,which was significantly higher than that in the basic group(78.1%),and the difference was statistically significant (P<0.05).The incidence rates of uterine atony,premature delivery,fetal distress,neonatal asphyxia,postpartum infection,and postpartum hemorrhage in the combined group were lower than those in the basic group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Labetalol combined with Magnesium Sulfate is effective in treatment of patients with preeclampsia,and it can improve the pregnancy outcome of patients,which is worthy of clinical promotion.
2019 Vol. 26 (2): 123-126 [Abstract] ( 94 ) HTML (36 KB)  PDF  (0 KB)  ( 16 )
127 Clinical effect of uterine artery chemoembolization combined with uterine curettage in the treatment of placenta implantation after vaginal delivery
YU You-hui;FAN Jian-hui;HUANG Can; SHI Jing
Objective To investigate the clinical effect of uterine artery chemoembolization combined with uterine curettage in the treatment of placenta implantation after vaginal delivery.Methods A total of 45 patients with placenta implanation after vaginal delivery who were admitted to our hospital from January 2013 to January 2018 were randomly divided into the observation group(23 cases)and the control group(22 cases).The control group was given drugs for treatment(Mifepristone combined with Methotrexate),and the observation group was treated with uterine artery chemoembolization,if the placenta failed to discharge by itself,the uterus curettage was performed 7 to 10 days after surgery.The therapeutic effect,adverse reactions and recovery(hospitalization time,quality of life questionnaire[SF-36]score)between the two groups were compared.Results The total effective rate in the observation group was 100.00%,which was higher than that in the control group accounting for 72.73%,and the difference was statistically significant(P<0.05).The total incidence rate of adverse reactions was 4.35%in the observation group,which was significantly lower than that in the control group(31.82%),and the difference was statistically significant(P<0.05).The hospitalization time of the observation group was(10.3±3.1)d,which was significantly shorter than that of the control group accounting for(15.1±4.9)d,and the difference was statistically significant(P<0.05).The score of SF-36 in the observation group was(91.3±5.9)points,which was significantly higher than that in the control group accounting for(79.9±6.3)points,and the difference was statistically significant(P<0.05).Conclusion Uterine artery chemoembolization combined with uterine curettage is effective in the treatment of placenta implantation after vaginal delivery.It can significantly shorten the hospitalization time and reduce the incidence rate of adverse reactions,and also reduce the risk of removing the uterus and losing fertility,which is worthy of clinical promotion.
2019 Vol. 26 (2): 127-130 [Abstract] ( 86 ) HTML (36 KB)  PDF  (0 KB)  ( 16 )
131 Clinical effect of Ambroxol combined with Budesonide atomized inhalation in the treatment of neonatal pneumonia
ZOU Zhao-cheng
Objective To investigate the clinical effect of Ambroxol combined with Budesonide atomized inhalation in the treatment of neonatal pneumonia.Methods Altogether 80 cases of neonatal children with pneumonia who were admitted to our hospital from December 2016 to November 2017 were selected as study subjects.According to the random number table method,the children were divided into the control group(40 cases)and the observation group(40 cases).All children were given routine treatment measures.The control group was given atomized inhalation of Ambroxol on the basis of the routine treatment,and the observation group was given Ambroxol combined with Budesonide atomized inhalation.The tidal breathing indexes(respiratory rate,tidal volume,peak time ratio,peak expiratory flow rate)before and after treatment were compared between the two groups,and the clinical symptom relief time (the disappearance time of the voice,lip purpura,cough and breath shortness),hospitalization time,treatment effect and adverse reactions were compared between the two groups.Results There were no significant differences in the tidal breathing indexes between the two groups before treatment(P>0.05).The respiratory rate and peak expiratory flow rate of the two groups after treatment were lower than those before treatment,the tidal volume was more than that before treatment,peak time ratio and peak expiratory flow rate were higher than those before treatment,and the differences were statistically significant(P<0.05).The respiratory rate and peak expiratory flow rate in the observation group after treatment were lower than those in the control group,the tidal volume was more than that in the control group,peak time ratio and peak expiratory flow rate were higher than those in the control group,and the differences were statistically significant(P<0.05).The clinical symptom relief time and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 97.50%,which was significantly higher than that in the control group (80.00%),and the difference was statistically significant(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion The combination of Ambroxol and Budesonide atomized inhalation can effectively improve the tidal breathing indexes of children,shorten the disappearance time of clinical symptoms,improve the therapeutic effect,and has a high clinical value,which is worthy of promotion.
2019 Vol. 26 (2): 131-133转136 [Abstract] ( 76 ) HTML (34 KB)  PDF  (0 KB)  ( 16 )
134 Effect of blood glucose control in gestational diabetes mellitus on maternal and fetal outcomes
LIN Xin-miao
Objective To explore the effect of blood glucose control in gestational diabetes mellitus on maternal and fetal outcomes.Methods The clinical data of 54 pregnant women with gestational diabetes mellitus who delivered in our hospital from January 2016 to January 2017 were retrospectively analyzed.Among them,the patients who underwent blood glucose control were selected as the observation group (27 cases),and those who did not control blood glucose effectively were selected as the control group (27 cases).The pregnancy outcomes and neonatal complications between the two groups were compared.Results The incidence rates of cesarean section,premature delivery,premature rupture of membranes and excessive amniotic fluid in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence rates of macrosomia,hypoglycemia and hyperbilirubinemia in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidence retes of hypocalcemia,asphyxia,and congenital malformation between the two groups(P>0.05).Conclusion Blood glucose control has an important effect on the maternal and infant outcomes of gestational diabetes mellitus.Therefore,early detection and control of blood glucose should be carried out to reduce the incidence of poor prognosis.
2019 Vol. 26 (2): 134-136 [Abstract] ( 90 ) HTML (28 KB)  PDF  (0 KB)  ( 16 )
137 Clinical effect of sutureless large incision manual cataract extraction in the treatment of hard nucleus cataract
YANG Hong-sheng;XIA Hou-li;YAN Si-zhen;XIA Huan
Objective To explore the clinical effect of suturless large incision manual cataract extraction (SLIMCE)in the treatment of hard nucleus cataract.Methods A total of 200 cases of hard nucleus cataract patients admitted to Fenyi People′s Hospital of Jiangxi Province from April 2016 to April 2018 were selected as the research objects,they were divided into control group (100 cases)and observation group (100 cases)according to random number table method.The control group was treated with traditional large incision extracapsular cataract extraction,while the observation group was treated with SLIMCE.The visual acuity,corneal astigmatism and corneal endothelial cell injury were compared between the two groups one week and one month after operation.Results One week after operation,the percentages of naked eye vision in the observation group were lower than those in the control group at 0.1-0.4 level,higher than those in the control group at>0.4-0.9 level,and higher than those in the control group at>0.9 leve,the differences were statistically significant(P<0.05).One month after operation,the proportion of naked eye vision in the observation group was lower than that in the control group at the level of>0.4-0.9,and the proportion of naked eye vision at the level of>0.9 was higher than that in the control group,the differences were statistically significant(P<0.05).The astigmatism of the observation group was lower than that of the preperative one week after operation,the astigmatisn one month after operation was lower than that preoprathve and dntol group,the endothelial cell reduction of the observation group was lower than that inpreaperative and control group one week and one month after operation,the differences were statistically significant(P<0.05).Conclusion SLIMCE is an effective method for hard nucleus cataract patients,which can improve their visual acuity and enhance the safety of treatment.
2019 Vol. 26 (2): 137-139 [Abstract] ( 75 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
140 Clinical effect of femtosecond laser-assisted phacoemulsification for cataract
LIU Xiao-jun;CHEN Run-lian;DENG Ju-liang;LIU Huan-tai
Objective To explore the clinical effect of femtosecond laser-assisted phacoemulsification for cataract.Methods Sixty cases (64 eyes)of cataract patients admitted to our hospital from October 2016 to October 2017 were selected as the research objects,they were randomly divided into conventional group and experimental group,30 cases(32 eyes)in each group.Conventional cataract phacoemulsification was performed in the conventional group,and femtosecond laser-assisted phacoemulsification was performed in the experimental group,relevant intraoperative indicators,naked visual acuity>0.5 and the incidence of intraocular lens deviation were compared between the two groups.Results The diameter of anterior capsulotomy in the experimental group was shorter than that in the conventional group,the ring tension of the capsule was higher than that in the conventional group,and the size of the capsule was smaller than that in the conventional group,the differences were statistically significant(P<0.05).The naked visual acuity >0.5 in the experimental group was higher than that in the routine group and 1 day after operation,the differences were statistically significant(P<0.05).The incidence of intraocular lens deviation in the experimental group was lower than that in the conventional group 1 day and 1 month and 6 months after operation,the difference was statistically significant(P<0.05).The incidence of intraocular lens deviation was higher in the experimental group 1 and 6 months after operation than that in the 1 day after operation,and the difference was statistically significant(P<0.05).Conclusion Femtosecond laser-assisted phacoemulsification for cataract patients can improve the related indicators,improve the visual acuity level of patients,and reduce the incidence of intraocular lens deviation.It is worthy of clinical application.
2019 Vol. 26 (2): 140-142 [Abstract] ( 80 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
143 Clinical effect of 1%Atropine Sulfate Eye Gel in the treatment of juvenile low myopia
YE Yong;OUYANG Lang;CHEN Hong-ru
Objective To explore the clinical effect of 1%Atropine Sulfate Eye Gel in the treatment of juvenile low myopia.Methods A total of 220 patients(440 eyes)with myopia or myopic astigmatism in our hospital from July 2015 to June 2017 were randomly divided into control group (110 cases/220 eyes)and observation group (110 cases/220 eyes),the control group was treated with spectacles,while the observation group was treated with 1%Atropine Sulfate Eye Gel,the intraocular pressure,diopter,eye axis,corneal curvature and naked eye vision of the two groups were compared before and after treatment for 1 week,1,2,3,6 months and 1 year.Results The diopter of the observation group after 1,2,3,6 months and 1 year treatment was higher than that before treatment,and the differences were statistically significant(P<0.05).The eye axis of the control group was longer 1,2,3,6 months and 1 year after treatment than that before treatment,and the differences were statistically significant(P<0.05).The diopter of the observation group was higher than that of the control group 1,2,3,6 months and 1 year after treatment,and the differences were statistically significant(P<0.05).The ocular axis of the observation group was shorter than that of the control group 2,3,6 months and 1 year after treatment,and the differences were statistically significant(P<0.05).Conclusion 1%Atropine Sulfate Eye Gel is effective in treating juvenile low myopia.It can effectively improve the diopter and axial changes of juvenile myopia.It is simple and feasible,and has high clinical value.
2019 Vol. 26 (2): 143-146 [Abstract] ( 91 ) HTML (35 KB)  PDF  (0 KB)  ( 14 )
147 Effect of Sodium Bicarbonate combined with Fluconazole in the treatment of diabetes mellitus complicated with oral Fungal infection
LU Yan
Objective To explore the effect of Sodium Bicarbonate combined with Fluconazole in the treatment of diabetes mellitus complicated with oral Fungal infection.Methods Eighty two patients with diabetes mellitus complicated with oral Fungal infections admitted to our hospital from January to December 2016 were selected as the research objects,they were divided into control group and observation group according to different treatment methods,with 41 cases in each group.The control group was treated with Fluconazole,while the observation group was treated with Sodium Bicarbonate on the basis of the control group.The clinical efficacy,oral pH value,leukoplakia area and total incidence of adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the observation group was higher than that of the control group,the difference was significant(P<0.05).After treatment,the oral pH value of the two groups was higher than that before treatment,and the area of white spot was smaller than that before treatment,the oral pH value of the observation group was higher than that of the control group,and the area of white spot was smaller than that of the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group(2.44%)was lower than that in the control group(12.20%),but there was no significant difference (P>0.05).Conclusion Sodium Bicarbonate combined with Fluconazole in the treatment of diabetes mellitus complicated with oral Fungal infection has good clinical effect,which is superior to Fluconazole alone in the treatment of diabetes mellitus complicated with oral Fungal infection.It can alleviate the internal environment of oral Fungal infection and is worthy of clinical application.
2019 Vol. 26 (2): 147-149 [Abstract] ( 93 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
150 Clinical effect of He-Ne laser combined with visual enhancement training in the treatment of high astigmatism amblyopia
LI Dan;SHEN Ling;DENG En-li
Objective To explore the clinical effect of He-Ne laser combined with visual enhancement training in the treatment of high astigmatism amblyopia.Methods A total of 260 children (459 eyes)with high astigmatism amblyopia admitted to the ophthalmological clinic of our hospital from July 2010 to July 2017 were selected as the study subjects,all the children were divided into treatment group(n=130,225 eyes)and control group(n=130,234 eyes),the treatment group was given He-Ne laser combined with visual enhancement training,while the control group was given traditional therapy(occlusion therapy),the treatment efficiency of the two groups after 3,6 months and 1 year of treatment was recorded and compared,the treatment effect of different types of astigmatism in the treatment group and the treatment efficiency of different refraction at different time points in the treatment group were also recorded and compared.Results The effective rate of the treatment group was higher than that of the control group after 6 months and 1 year of treatment(P<0.05).The total effective rate of hyperopic astigmatism was the highest in children with simple hyperopic astigmatism(P<0.05),the total effective rate was the lowest in children with compound myopic astigmatism(P<0.05).After 3 months of treatment,the effective rates of children with 2.00-<2.75 D and 2.75-<3.50 D were higher than those of children with ≥3.50 D (P<0.05).After 6 months of treatment,the effective rate of children with 2.00-<2.75 D was higher than that of the other two groups,the effective rate of children with 2.75-<3.50 D was higher than that of children with ≥3.50 D,the differences were statistically significant(P<0.05).After one year of treatment,the effective rate of children with 2.00-<2.75 D was higher than that of the other two groups,the effective rate of treatment in children with 2.75-<3.50 D was higher than that in children with ≥3.50 D,the differences were statistically significant(P<0.05).Conclusion He-Ne laser combined with visual enhancement training is safe and effective in the treatment of high astigmatism amblyopia,which can significantly improve the visual acuity of children,especially in children with 2.00~<2.75 D simple high hyperopic astigmatism amblyopia.
2019 Vol. 26 (2): 150-152 [Abstract] ( 105 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
153 Clinical effect analysis of phacoemulsification combined with goniosynechialysis in the treatment of angle-closure glaucoma with cataract
TANG Jing;RUXIANGULI Ai-zezi
Objective To explore the effect of phacoemulsification combined with goniosynechialysis in the treatment of angle-closure glaucoma with cataract,and to provide reference for the treatment of ophthalmic complications.Methods A total of 60 patients with angle-closure glaucoma and cataract were treated surgically in our ophthalmology department from December 2014 to August 2016 were selected as the study subjects,phacoemulsification combined with goniosynechialysis was used for 1-year follow-up.The best visual acuity correction and intraocular pressure were compared before and after operation,and adverse reactions were analyzed.Results The best visual acuity correction after operation was better than that before operation,the difference was statistically significant(P<0.05).The intraocular pressure after operation was significantly lower than that before operation,the difference was statistically significant(P<0.05).There were 5 cases of corneal edema and 9 cases of iris inflammation after drug treatment,the inflammation was controlled after drug treatment.Conclusion Phacoemulsification combined with goniosynechialysis for angle closure glaucoma with cataract is safe and effective.It has significant effect on the correction of vision and improvement of intraocular pressure in patients with angle closure glaucoma.It has combined application value.
2019 Vol. 26 (2): 153-155 [Abstract] ( 80 ) HTML (32 KB)  PDF  (0 KB)  ( 15 )
156 Detection significance of CCL-18 and CyclinD1 in oral and maxillofacial malignant tumors
QI Xiao-yu;AN Ying-jie
Objective To explore the significance of CCL-18 and CyclinD1 in the detection of oral and maxillofacial malignant tumors.Methods Sixty four patients with oral and maxillofacial malignant tumors admitted to our hospital from February 2016 to February 2018 were selected as the analysis group,and 64 healthy volunteers at the same period were selected as the reference group,serum tests were performed in both groups.Routine examinations were performed once in the control group.The patients in the analysis group were tested before and 1 month after the treatment,preoperative serum levels of CCL-18 and CyclinD1 were compared between the two groups.The levels of CCL-18 and CyclinD1 in serum before and after operation,different pathological types,lymph node metastasis and different clinical stages were compared and analyzed.Results The levels of CCL-18 and CyclinD1 in serum of the analysis group before operation were higher than those of the control group,the differences were statistically significant(P<0.05).The levels of CCL-18 and CyclinD1 in the serum of the analysis group at 1 month after operation were lower than those before operation,and the differences were statistically significant(P<0.05).The level of CCL-18 in serum of patients without lymph node metastasis was significantly lower than that of patients with lymph node metastasis,the difference was significant(P<0.05).The level of CCL-18 in serum of patients with stage II was significantly higher than that of patients with other 3 stages,the difference was significant(P<0.05).The level of serum Cyclin D1 in patients with stage II was significantly lower than that in patients with other 3 stages,the difference was significant(P<0.05).Conclusion Compared with healthy volunteers,the serum levels of CCL-18 and CyclinD1 in patients with oral and maxillofacial malignant tumors were significantly higher,which can be considered as an assistant diagnostic method for maxillofacial malignant tumors,and have a certain reference value.
2019 Vol. 26 (2): 156-158转161 [Abstract] ( 86 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
159 Application effect of combined periodontal and pulpal therapy in patients with severe periodontitis
WANG Hong
Objective To explore the application effect of combined periodontal and pulpal therapy in patients with severe periodontitis.Methods A total of 26 patients(38 offending teeth)with severe periodontitis treated in outpatient department of stomatology in our hospital from March 2017 to March 2018 were randomly divided into study group and control group,with 13 cases(19 offending teeth)in each group.The study group was treated with combined periodontal and pulpal therapy,while the control group was treated with simple periodontal therapy.The patients were followed up for 6 months,the PDD,RAL,CEJ-BD,CEJ-AC and CADIA were compared between the two groups 3 and 6 months after treatment.Results After 3 and 6 months of treatment,PPD,RAL,CEJ-BD and CEJ-AC in the two groups were lower than those before treatment,and CADIA was higher than those before treatment,the differences were statistically significant(P<0.05).After 3 and 6 months of treatment,CEJ-BD,CEJ-AC and CADIA in the study group were lower than those in the control group,and higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Compared with simple periodontal therapy,combined periodontal and pulpal therapy is more conducive to the recovery of bone tissue and has better therapeutic effect.
2019 Vol. 26 (2): 159-161 [Abstract] ( 88 ) HTML (28 KB)  PDF  (0 KB)  ( 15 )
162 Anesthesia effect comparison of Etomidate and Propofol for general anesthesia induction in laparoscopic surgery for ectopic pregnancy
CHEN Kuang-dong;WANG Xing-gao;ZHUO Rui
Objective To compare the anesthetic effect of Etomidate and Propofol for general anesthesia in laparoscopic surgery for ectopic pregnancy.Methods A total of 90 patients with ectopic pregnancy who underwent laparoscopic surgery from October 1,2017 to June 30,2018 in our hospital were selected.According to the admission time,they were divided into the control group and observation group,and there were 45 cases in each group.Patients in the control group were provided with general anesthesia with Propofol,and in the observation group,Etomidate for general anesthesia induction was used.Change of heart rate and blood pressure in before anesthesia(T0),after induction(T1),1 minute after intubation (T2),and 5 minutes after intubation (T3)in ectopic pregnancy patients undergone laparoscopic surgery were compared.The eyes open time,extubation time and orientation recovery time between the two groups were compared.Results The heart rate and systolic blood pressure at T1in patients of the observation group were significantly higher than those in the control group,and the diastolic blood pressure was lower than that in the control group,and the eyes opening time,extubation time and orientation recovery time in patients of the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Compared with Propofol,Etomidate is more effective in laparoscopic surgery for ectopic pregnancy,and with sooner recovery in patients.
2019 Vol. 26 (2): 162-164 [Abstract] ( 91 ) HTML (35 KB)  PDF  (0 KB)  ( 17 )
165 Application effect of Dezocine administered at different time points in patients undergoing laparoscopic surgery
YE Hua;YANG Xian-ping;ZHU Zhi-qiao;WANG Jing-ye;CHEN Min-ling;TAN Jie-yin;LIAO Cui
Objective To compare the application effect of Dezocine administered at different time points in patients undergoing laparoscopic surgery.Methods All of 105 patients scheduled for gynecologic laparoscopy treated in our hospital from June 2016 to July 2018 were selected,and they were randomly divided into group A(n=52)and group B(n=53).Patients in group A received intravenous injection of Dezocine 60 min before end surgery.Patients in group B received same intervene 20 min before end surgery.At the same time,20 patients were set up as blank control group.The recovery time of anesthesia,restlessness score during recovery and incidence of adverse reactions after recovery were compared in patients among the three groups.Results The restlessness score of group A and group B were lower than those of the blank control group at the time of recovery and 5,10 and 20 minutes after extubation(P<0.05).At 20 minutes after extubation,the agitation score in group B was lower than that in group A(P<0.05).The recovery time was the longest in group B,followed by group A and the shortest in blank control group(P<0.05).The total incidence of adverse reactions was 9.62%,9.43%and 10.00%respectively in group A,group B and blank control group at 24 hours after operation,and there was no significant difference (P>0.05).Conclusion Intravenous injection of appropriate amount of Dezocine before end operation can effectively prevent restlessness during recovery period of general anesthesia in gynecological laparoscopic patients,and intravenous injection of Dezocine 60 minutes before operation can effectively prevent restlessness during recovery period in patients with gynecological laparoscopic surgery.
2019 Vol. 26 (2): 165-167 [Abstract] ( 86 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
168 Anesthesia effect of 0.3%Ropivacaine for continuous epidural block in percutaneous nephrolithotomy
LIU Da-qing;ZHANG Jian-bo;ZENG Wei-xiang;CHENG Cai-ni
Objective To explore the anesthetic effect of 0.3%Ropivacaine for continuous epidural block in percutaneous nephrolithotomy.Methods All of 161 patients with percutaneous nephrolithotomy treated in our hospital from January 2017 to January 2018 were selected and divided into the control group (n=80)and the observation group (n=81)according to the random number table method.The control group received 0.1%Lidocaine+0.5%Ropivacaine for continuous epidural anesthesia,and the observation group received 0.3%Ropivacaine for continuous epidural anesthesia.Hemodynamic indexes,analgesic effect and muscle strength at different time points were compared in patients between the two groups during perioperative period.Results The heart rate and mean arterial pressure at T1,T2and T3 were higher than those at T0in patients of the two groups,and the differences were statistically significant(P<0.05).Compared with at T0,there was no significant difference in oxygen saturation at T1,T2and T3in the two groups (P>0.05).There was no significant difference in heart rate,mean arterial pressure and oxygen saturation at T1,T2and T3 between the two groups (P>0.05).There was no significant difference in VAS scores at T0,T1,T2and T3in patients between the two groups(P>0.05).The muscle strength of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions in patients between the two groups (P>0.05).Conclusion Continuous epidural anesthesia with 0.3%Ropivacaine has a good anesthetic effect in the percutaneous nephrolithotomy.It has little effect on hemodynamics,the analgesic effect is accurate,the effect of muscle relaxation is not obvious,and it is safe and reliable.
2019 Vol. 26 (2): 168-170转173 [Abstract] ( 83 ) HTML (40 KB)  PDF  (0 KB)  ( 11 )
171 Effect comparison of B-ultrasound guided nerve block and traditional nerve block in upper limb nerve block anesthesia
LIU Li-li;ZHENG Qiu-wu
Objective To compare the effect of B-ultrasound guided nerve block and traditional nerve block in upper limb nerve block anesthesia.Methods A total of 128 patients given upper extremity surgery in our hospital from May 2016 to February 2018 were selected as observation objects and they were divided into the control group (n=64)and study group (n=64)according to odd or even number.In the control group,blind brachial plexus block anesthesia was selected,while in the study group,B-ultrasound guided brachial plexus block anesthesia was selected.The anesthetic effect between the two groups was compared.Results The excellent and good rate of anesthesia in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).The operation time,drug onset time in the study group were shorter than those of the control group,and anesthetic drug dose was less than that of the control group,and the anesthesia maintenance time was longer than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Compared with the traditional nerve block,B-ultrasound guided nerve block is superior in patients with upper limb surgery.It can quickly take effect,shorten the operation time,reduce the dose f the drug,and prolong the action time,which is worthy of clinical selection and promotion.
2019 Vol. 26 (2): 171-173 [Abstract] ( 64 ) HTML (28 KB)  PDF  (0 KB)  ( 13 )
174 Application effect of Midazolam combined with Sufentanil in sedation and analgesia in patients with severe acute pancreatitis
CHEN Ming-di;TIAN Bin-bin;WU Qing-lan;ZENG Yu;HUANG Rong-xian
Objective To observe the application effect of Midazolam combined with Sufentanil in sedation and analgesia in patients with severe acute pancreatitis(SAP).Methods All of 62 patients with SAP treated in clinical surgery of the Second Affiliated Hospital of Guangdong Medical University from January 2016 to January 2018 were selected and they were randomly divided into the research group(n=31)and the control group(n=31).The research group received Midazolam and Sufentanil,and the control group received Midazolam and Morphine.The sedative and analgesic effect between the two groups were compared.Results The time of sedation reaching the standard,awakening time after drug withdrawal and total hospitalization time of the study group were shorter than those of the control group,and the incidence of adverse reactions was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Midazolam combined with Sufentanil applied in SAP has good analgesic and sedative effect,good safety and is worthy of application.
2019 Vol. 26 (2): 174-176 [Abstract] ( 81 ) HTML (31 KB)  PDF  (0 KB)  ( 15 )
177 Application effect comparison of target-controlled infusion of Sufentanil and Remifentanil in gynecological laparoscopic surgery anesthesia
CHEN Rong-qiang;MAI Wei-liang;ZHANG Min-sen ;HUANG Xiao-hua
Objective To investigate the application effect of target-controlled infusion of Sufentanil and Remifentanil in gynecological laparoscopic surgery anesthesia.Methods Eighty patients given gynecologic laparoscopic surgery treated in our hospital from March 2016 to October 2017 were selected and they were divided into the two groups according to different target-controlled infusion drugs,there were 40 cases in each group.The control group was given targetcontrolled infusion of Remifentanil while the study group was given target-controlled infusion of Sufentanil.The hemodynamic index before anesthesia(t0),3 min after induction(t1),tracheal intubation(t2),skin incision(t3),laparoscopic probing (t4),and extubation (t5);postoperative awakening time,tracheal intubation/extubation time,time of appeal for analgesics for the first time;the observer assessment of alertness/sedation scale (OAAS)score,and visual analogue scale (VAS)score were compared in patients between the two groups.Results The level of heart rate (HR),systolic blood pressure(SBP)and diastolic blood pressure(DBP)at t1and t5were significantly different from those at t0in patients of the two groups(P<0.05).The level of HR,SBP and DBP in the study group were significantly different from those in the control group at t1and t5(P<0.05).The time of postoperative awakening,tracheal intubation/extubation time,time of appeal for analgesics for the first time in the study group were obviously longer than those in the control group (P<0.05).In the study group,the OAAS maximal score within 30 min of staying at resuscitation room and VAS score before leaving resuscitation room were both lower compared with those in the control group (P<0.05).There was no significant difference in the maximal scores of OAAS between the two groups staying at the resuscitation room for over 30 min (P>0.05).Conclusion Hemodynamics of target-controlled infusion of Sufentanil and Remifentanil applied in gynecological laparoscopic surgery anesthesia are relatively stable,and recovery by Remifentanil is sooner than that by Sufentanil,but postoperative pain is severe.
2019 Vol. 26 (2): 177-179 [Abstract] ( 91 ) HTML (36 KB)  PDF  (0 KB)  ( 14 )
180 Anesthetic effect of painless oral local anesthesia instrument in the treatment of oral demyelination
ZHONG Jian-ping;PAN Feng;LIU Yan;ZHENG Wei;OUYANG Nan-qi
Objective To investigate the anesthetic effect of oral local anesthesia apparatus of single tooth anesthesia(STA)in the treatment of oral demyelination.Methods From December 2017 to May 2018,80 patients with acute and chronic pulpitis were selected as study objects and they were divided into the two groups according to the the random number table method.The observation group was given STA,while the control group was given conventional local anesthesia way.The VAS score,anesthesia effect,and heart rate were compared between the two groups.Results The VAS score in the observation group was(2.21±1.08)points which was significantly lower than that in the control group(6.62±1.46)points(P<0.05).The good and excellent rate of anesthetic effect in the observation group(87.5%)was significantly higher than that in the control group (20.0%)(P<0.05).After anaesthesia,the heart rate of the observation group was(73.65±8.15)times/min,which was significantly lower than that of the control group ([80.46±10.27]times/min)and([80.41±10.22]times/min)before anesthesia(P<0.05).Conclusion Oral local anesthesia apparatus of STA can effectively relieve pain during oral demyelination,stabilize the patients′heart rate,and ensure the successful completion of surgery.
2019 Vol. 26 (2): 180-182 [Abstract] ( 99 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
183 Application effect of Propofol intravenous anesthesia in patients with acute severe craniocerebral injury surgery
PAN Ming;JIA Yan-jie
Objective To investigate the application effect of Propofol intravenous anesthesia in patients with acute severe craniocerebral injury surgery.Methods From June 2014 to June 2017,118 patients with acute severe craniocerebral injury were selected and they were randomly divided into the control group (59 cases)and the observation group(59 cases).The control group was anesthetized with Etomidate,while the observation group was anesthetized with Propofol.The intracranial pressure(ICP),cerebral oxygen partial pressure(PbrO2),cellular inflammatory factor level and recovery time were compared between the two groups.Results The ICP of T4and T5in the observation group was lower than that of the control group,the PbrO2of T4and T5in the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).The IL-1,IL-6,TNF-α and S100β level in the observation group were lower than those of the control group at T5,and the differences were statistically significant(P<0.05).The recovery time for the first time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Propofol intravenous anesthesia applied in patients with acute severe craniocerebral injury surgery protect brain function,reduce inflammation and shorten postoperative recovery time in patients.
2019 Vol. 26 (2): 183-185 [Abstract] ( 81 ) HTML (35 KB)  PDF  (0 KB)  ( 10 )
186 Clinical application effect of low dose Dexmedetomidine Hydrochloride in resuscitation and extubation period of general anesthesia
YING Chao
Objective To study the application effect of low dose Dexmedetomidine Hydrochloride in resuscitation and extubation period of general anesthesia.Methods All of 90 patients with general anesthesia and operation treated in our hospital from August 2016 to December 2017 were selected as study subjects.They were randomly divided into the control group(45 cases)and observation group(45 cases).The observation group was given the low dose Dexmedetomidine Hydrochloride while the control group was given normal saline.The change of blood pressure,heart rate and recovery were compared between the two groups.Results There was no significant difference in blood pressure and heart rate before anesthesia,10 minutes after anesthesia and at extubation between the two groups(P>0.05).The blood pressure and heart rate at extubation in patients of the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference of the related indicators of awakening between the two groups(P>0.05).Conclusion Low dose Dexmedetomidine Hydrochloride plays an important role in in resuscitation and extubation period of general anesthesia and can improve the blood pressure and heart rate.It is worthy of study.
2019 Vol. 26 (2): 186-188 [Abstract] ( 93 ) HTML (28 KB)  PDF  (0 KB)  ( 15 )
189 Application effect comparison of different positioning methods in brachial plexus block
HUANG Xiao-juan
Objective To investigate the application effect of different positioning methods in brachial plexus block.Methods From May 2015 to August 2017,100 patients with upper extremity fracture treated in our hospital were selected as study subjects.According to the block randomization method,the patients were divided into the control group(n=50)and the experimental group (n=50).The control group was given traditionally anatomical positioning during the intervention of brachial plexus block.The experimental group was given ultrasound-guided positioning.The doses of anesthetics,the duration of analgesia,the onset time of anesthesia,the duration of block operation,the anesthetic effect,and incidence of complications were compared between the two groups.Results The anesthetic dosage in the experimental group was (17.24±2.53)ml,which was ower than that of the control group,the anesthesia onset time was(11.54±2.88)min,and the duration of block operation was(185.52±24.85)s,which were shorter than those of the control group,and the duration of analgesia in the experimental group was(11.41±2.38)h,which was longer than that of in the control group,and the differences were statistically significant(P<0.05).The excellent and good rate of anesthesia in the experimental group was 98.00%,which was higher than that in the control group,and the difference was statistically significant(P<0.05).The total incidence rate of complication in the experimental group was 0.00%,which was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Ultrasoundguided positioning in brachial plexus block can achieve better anesthetic effect and higher safety.
2019 Vol. 26 (2): 189-191 [Abstract] ( 85 ) HTML (29 KB)  PDF  (0 KB)  ( 8 )
192 Application effect of Dexmedetomidine in patients with thyroid operation
SUN Yun
Objective To investigate the application effect of Dexmedetomidine in patients with thyroid operation.Methods All of 180 patients with thyroid surgery treated in our hospital from May 2015 to July 2017 were selected.According to the different drugs used during extubation of general anesthesia,the patients were divided into the observation group and control group,there were 90 cases in each group.The observation group was given 0.5 μg/kg Dexmedetomidine during tracheal intubation and extubation under general anesthesia,while the control group was injected with the same amount of normal saline.Results There was no significant difference in operation time,eye opening time and extubation time between the two groups (P>0.05).The heart rate and systolic blood pressure of the observation group were lower than those of the control group at injection of Dexmedetomidine or saline (t3),extubation (t4)and 1 min(t5)after extubation,and the differences were statistically significant(P<0.05).The incidence rate of cough,nausea and vomiting in the observation group was significantly lower than that in the control group(P<0.05).The incidence of hypotension and bradycardia was significantly higher than that in the control group(P<0.05).Conclusion The clinical effect of Dexmedetomidine during extubation under general anesthesia is better,which can effectively reduce the occurrence of cough,nausea and other adverse reactions.
2019 Vol. 26 (2): 192-194 [Abstract] ( 87 ) HTML (34 KB)  PDF  (0 KB)  ( 3 )
195 Clinical effect of Metformin combined with Acarbose in treatment of type 2 diabetes mellitus with hyperlipidemia
HE Tian-xiu;WANG Mei-zhen;XU Rui-guang
Objective To investigate the clinical effect of Metformin combined with Acarbose in the treatment of type 2 diabetes mellitus (T2DM)with hyperlipidemia.Methods A total of 82 cases of T2DM and hyperlipidemia admitted to our hospital from October 2016 to May 2018 were selected as subjects and were randomly divided into 2 groups.Fortyone patients in the control group were treated with Acarbose and forty-one patients in the study group were treated with Metformin.The clinical efficacy,fasting blood glucose(FPG),2 h postprandial blood glucose(2 h PG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),diastolic blood pressure(DBP),and systolic blood pressure(SBP)were compared between the two groups.Results The total effective rate of the study group (95.12%)was significantly higher than that of the control group (70.73%),the difference was statistically significant(P<0.05).There was no significant difference in FBG,2 h PG,HbA1c,TC,TG,LDL-C,HDL-C,DBP and SBP levels between the two groups before intervention(P>0.05).The levels of FBG,2 h PG,HbA1c,TC,TG,DBP and SBP in the two groups after intervention were lower than those before intervention,and the levels in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The level of HDL-C in study group was higher than that before intervention,and the level of LDL-C in study group was lower than that before intervention,and the differences were statistically significant(P<0.05).Conclusion Metformin is effective in the treatment of T2DM and hyperlipidemia with Acarbose,which is worthy of clinical application.
2019 Vol. 26 (2): 195-197 [Abstract] ( 89 ) HTML (36 KB)  PDF  (0 KB)  ( 14 )
198 Clinical effect of Weifuchun Tablets combined with Esomeprazole Magnesium Enteric-coated Tablets in the treatment of duodenal bulbar ulcer in the spleen and stomach deficiency pattern
LUO Guo-liang;YANG Si-wei;LIU Xi-jian;ZHEN Hui-lian
Objective To investigate the efficacy of Weifuchun Tablets combined with Esomeprazole Magnesium Enteric-coated Tablets in the treatment of duodenal bulbar ulcer in the spleen and stomach deficiency type.Methods A total of 100 patients with duodenal bulbar ulcer identified as spleen and stomach deficiency pattern who were admitted to our hospital from September 2016 to February 2018 were enrolled in the study.They were equally divided into treatment group 1 and treatment group 2 according to the random number table.In the treatment group 1,WeifuchunTablets combined with Esomeprazole Magnesium Enteric-coated Tablets was used,while in the treatment group 2,Esomeprazole Magnesium Enteric-coated Tablets alone was adopted.The efficacy of treatment,the disappearance time of abdominal pain and ulcer,visual simulation score (VAS),daily living ability (ADL)score and adverse reactions were compared between the two groups.Results The total effectiveness rate of the treatment group 1 was 98.00%,which was higher than that of the treatment group 2 accounting for 86.00%with a statistical difference(P<0.05).The time of abdominal pain and ulcer disappeared in the treatment group 1 was shorter compared with those in the treatment group 2 with statistical significance (P<0.05).The total incidence of adverse reactions was 6.00%in the treatment group and 10.00%in the treatment group.There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).There was no statistically significant difference between the two groups in VAS and ADL score before treatment(P>0.05).After treatment,the VAS score of treatment group 1 was lower than that of the treatment group 2,and the ADL score was higher than that of the treatment group 2,the differences were statistically significant(P<0.05).Conclusion The application of Weifuchun Tablets combined with Esomeprazole Magnesium Enteric-coated Tablets in the treatment of patients with duodenal bulbar ulcer identified as spleen and stomach deficiency pattern is not only safe and reliable,but also exerts a remarkable curative effect.The disappearance time of patient′s abdominal pain and ulcer is short.It is worthy of application and promotion.
2019 Vol. 26 (2): 198-201 [Abstract] ( 166 ) HTML (36 KB)  PDF  (0 KB)  ( 11 )
202 Clinical effect of integrated Chinese traditional and western medicine therapy for dry eye syndrome
JIANG Yan-hua; LI Ruo-xi;TONG Tian
Objective To observe the effect of decoction and ear acupoint pressing method in treating dry eye syndrome.Methods A total of 100 patients with dry eye syndrome in the Fourth People′s Hospital in Shenyang City from July 2017 to May 2018 were selected as subjects.The patients were divided into treatment group and control group by random number table method,with 50 cases in each group.The patients in the control group were treated with Artificial Tear Drops,and the patients in the treatment group were treated with internal decoction plus auricular point sticking on the basis of the control group.After 1 month of treatment,clinical symptom scores,tear secretion test(SIT),tear film rupture time(BUT)and corneal fluorescein staining(FL)were compared between the two groups.The total therapeutic efficiency of the two groups was compared.Results The clinical symptom scores,SIT,BUT and FL of patients in the treatment group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The comprehensive treatment of decoction and ear acupoint pressing method with sodium hyaluronate eye drops in treating dry eye syndrome is more effective than sodium hyaluronate eye drops alone,it deserves to popularize.
2019 Vol. 26 (2): 202-204转208 [Abstract] ( 78 ) HTML (36 KB)  PDF  (0 KB)  ( 12 )
205 Effect of Modified Buqi Huoxue Recipe on interleukin-6,C-reactive protein and fibrinogen in patients with deep venous thrombosis after orthopedics surgery
WEI Xing-xing
Objective To investigate the effect of Modified Buqi Huoxue Recipe on interleukin-6 (IL-6),C-reactive protein(CRP)and fibrinogen(FIB)in patients with deep venous thrombosis after orthopedics surgery.Methods A total of 78 patients with lower extremity deep venous thrombosis admitted to our hospital from January 2016 to March 2018 were selected as subjects.According to the random number table method,78 patients were divided into control group and observation group,39 cases in each group.The control group was treated with basic western medicine,observation group on the basis of the control group plus Modified Buqi Huoxue Recipe.After treatment,the levels of IL-6,CRP and FIB were compared between two groups,the difference of the circumference of the lower limbs between the two groups before and after treatment was compared,and the clinical efficacy was compared.Results The levels of IL-6,CRP and FIB in the two groups were lower than before(P<0.05);and observation groups′indicators were lower than the control group (P<0.05).The 15 cm diameter and circumference difference of patella superior and patella lower margin between the two groups of patients after treatment were lower than those before treatment,and the 15 cm diameter and circumference difference of patella superior and patella lower margin after treatment in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The total clinical effective rate of the observation group after treatment was 92.31%,higher than that of the control group(61.54%),and the difference was statistically significant(P<0.05).Conclusion Modified Buqi Huoxue Recipe has obvious curative effect on target patients.It can improve the levels of IL-6,CRP and FIB,and eliminate the deep venous thrombosis.It is worth popularizing.
2019 Vol. 26 (2): 205-208 [Abstract] ( 81 ) HTML (36 KB)  PDF  (0 KB)  ( 19 )
209 Clinical effect of acupoint embedding combined with intense pulsed light in the treatment of chloasma
CHEN Xiao-qiong ;XIAO Wei-mian
Objective To observe the clinical effect of acupoint embedding combined with intense pulsed light in the treatment of chloasma.Methods A total of 120 patients with chloasma treated in our hospital from December 2016 to November 2017 were selected as subjects,and they were divided into the treatment group (60 cases)and the control group (60 cases)according to the random number table method.The treatment group was treated with syndrome differentiation acupoint embedding combined with intense pulsed light therapy once a month,and syndrome differentiation acupoint embedding was conducted half an hour before light therapy,while the control group was treated with intense pulsed light alone once a month with a course of 5 months.The chloasma area and severity index (MASI)score before and after treatment and the total effective rate of treatment were compared between the two groups.The absolute value of the VISIA image analysis system score before and after treatment and the improvement rate of skin pigmentation were compared between the two groups.The adverse reactions of the two groups were compared.The recurrence rates of the two groups were compared.Results After treatment,MASI score and VISIA image analysis system absolute score in both groups were lower than those before treatment,the differences were statistically significant(P<0.05).MASI score and VISIA image analysis system absolute score were lower in the treatment group than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the treatment group was 82.46%,which was higher than 53.45%of the control group,the difference was statistically significant(P<0.01).The improvement rate of skin pigmentation in the treatment group was higher than that in the control group,the difference was statistically significant(P<0.05).No serious adverse reactions occurred in either group.After 12 weeks of follow-up,the recurrence rate of patients in the treatment group was 7.0%,which was lower than 15.5%in the control group,and the difference was statistically significant (P<0.05).Conclusion The combined treatment of chloasma with acupoint embedding and intense pulsed light can improve clinical efficacy and reduce recurrence rate.
2019 Vol. 26 (2): 209-212 [Abstract] ( 93 ) HTML (38 KB)  PDF  (0 KB)  ( 18 )
213 Research and application of PDCA hospital performance management based on resource-based relative value scales and key performance indicators
LI Bao-xiang;YUAN Xiao-hong;QIN Da-wei;MENG Fan-shun;JIANG Liang-mei;ZHOU Hao
It is the need of new medical reform and public hospital reform to construct a set of hospital performance management system which is in line with the characteristics of China's medical and health industry,fair and reasonable,scientific system and effective.Through the literature review of domestic and foreign hospital performance management research status,analysis and comparison of hospital performance appraisal methods,summed up a set of resource consumption based on resource-based relative value scales (RBRVS)and key performance indicators(KPI)combined PDCA hospital performance management system,so as to provide a certain degree of practical experience and guidance for the implementation of hospital performance management in China.
2019 Vol. 26 (2): 213-217 [Abstract] ( 85 ) HTML (41 KB)  PDF  (0 KB)  ( 14 )
218 Application effect of refined health checkup management mode in physical examination center
ZHAO Rui-hua;CUI Sheng;YU Jun-jie;LIU Yue-sheng
Objective To analyze the application effect of fine physical examination management mode in physical examination center.Methods A total of 54 physical examinees in the Medical Examination Center of our city from April 2016 to April 2017 were selected as the control group,which received traditional conventional management mode.A total of 54 physical examinees in the Medical Examination Center of our city from May 2017 to May 2018 were selected as the seminar group,which received fine physical examination management mode.The service satisfaction,mastery of health knowledge and quality of life scores between the two groups were compared.Results After the physical examination of the two groups,the total satisfaction of the medical examinees in the seminar group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The total awareness rate of health knowledge in the seminar group was higher than that in the control group,and the difference was statistically significant(P<0.05).The scores in the seminar group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The nursing satisfaction of physical examination patients is improved by adopting the fine management mode of physical examination in physical examination center.The application effect is ideal.It is worth further popularizing in the future physical examination management.
2019 Vol. 26 (2): 218-220 [Abstract] ( 83 ) HTML (33 KB)  PDF  (0 KB)  ( 18 )
221 Effect of psychological nursing intervention on pregnancy outcome and postpartum depression in pregnant women and puerpera
WU Hui-ping
Objective To analyze the effect of psychological nursing intervention on the pregnancy outcome and postpartum depression in pregnant women and puerpera.Methods From September 2016 to January 2018,a total of 150 cases of puerpera were included in the study.According to the grouping methods of admission order,they were divided into the observation group (75 cases)and the control group (75 cases).In the control group,the puerpera were given routine nursing intervention.In the observation group,the puerpera were given psychological intervention based on the control group.The delivery outcomes and postpartum depression were analyzed in the two groups of puerpera.Results The vaginal delivery rate in the observation group was significantly higher than that in the control group (P<0.05).Its cesarean section rate was significantly lower than that in the control group (P<0.05).The postpartum bleeding rate was also lower than that in the control group,the difference was statistically significant(P<0.05).In addition,the postpartum anxiety and depression scores in the puerpea in the observation group were also lower than those in the control group,the quality of life scores were significantly higher than those in the control group.The differences were significantly different(P<0.05).In the neonatal Apgar score (Apgar),the scores in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Psychological intervention can effectively improve the negative emotions of the puerperal,so that they can better control their own temperament and improve their expectation of childbirth.It can make them face delivery with an optimistic attitude,improve the vaginal delivery rate,and ensure maternal and child health.
2019 Vol. 26 (2): 221-223 [Abstract] ( 79 ) HTML (31 KB)  PDF  (0 KB)  ( 12 )
224 Correlation analysis between health literacy and self-management ability in patients with type 2 diabetes mellitus
ZHOU Dan
Objective To analyze the correlation between health literacy and self-management ability in patients with type 2 diabetes mellitus (T2DM).Methods Sixty T2DM patients admitted to our hospital from January to May 2018 were enrolled in the study.According to the level of health literacy,they were divided into observation group(high health literacy)and control group(low health literacy),30cases in each group.Health education was instructed for them in order to analyze the relationship between patient′s health literacy and self-management ability.Results After nursing,the scores of emotional area,social area,mental health,and physiological area in the observation group were higher than those of the control group (P<0.05).There was a positive correlation between health literacy level and selfmanagement behavior as well as self-efficacy.That′s to say,the higher the patient′s health literacy level was,the higher the self-management behavior and self-efficacy scores get.Conclusion There is a correlation between the health literacy of patients with T2DM and the self-management ability.If the health literacy in T2DM patients is low,it is easy to lead to a decline in self-management ability,identify people with low health literacy and strive to improve their health literacy.
2019 Vol. 26 (2): 224-225转231 [Abstract] ( 50 ) HTML (27 KB)  PDF  (0 KB)  ( 14 )
226 Application effect of family doctor care service mode in patients with newly diagnosed sputum positive tuberculosis
ZHUANG Rong-zhen;LIANG Zhi-quan;YANG Rong;CHEN Rong-jiao;HE Yan
Objective To explore the application effect of family doctor care service mode in patients with newly diagnosed sputum positive tuberculosis.Methods Sixty patients with newly diagnosed sputum-positive pulmonary tuberculosis admitted to our institute from May 2016 to July 2017 were enrolled.They were divided into control group and experimental group according to random number table method,30 cases in each group.The patients in the control group were provided with the anti-tuberculosis regimen.In the experimental group,the family doctor care service mode as an assistance to the anti-tuberculosis regimen was adopted.The treatment compliance within one year,and the anxiety and depression scores after one year,and the negative conversion ratio of sputum in different time were compared in the two groups.Results During the intervention period,the correct medication rate and daily self-management scores of the experimental group were higher than those of the control group with statistical differences(P<0.05).The anxiety and depression scores of the experimental group were significantly lower compared with those of the control group (P<0.05).The negative conversion ratio of sputum after one-and-two-month intervention in the experimental group was significantly higher than that of the control group with statistical significance(P<0.05).The negative conversion ratio of sputum was not displayed statistical difference after 3-month intervention in the two groups(P>0.05).Conclusion The implementation of the family doctor care service model for patients with newly diagnosed sputum positive tuberculosis can effectively alleviate patients′anxiety and depression in a good treatment compliance and a quick negative conversion ratio of sputum.
2019 Vol. 26 (2): 226-228 [Abstract] ( 74 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
229 Application effect of risk awareness in operating room nursing management
SONG Yan
Objective To explore the application effect of risk awareness in the management of operating room nursing.Methods Eighty patients who underwent surgery from July 2017 to July 2018 in our hospital were selected as the study subjects.The patients were divided into the control group(40 cases)and the observation group(40 cases)according to the patient′s admission time sequence.The control group was used conventional operating room nursing management method,the observation group was adopts risk awareness.The surgical quality scores,patient care satisfaction,and risk event rates were compared between the two groups.Results The total incidence of risk events in the observation group was 5.00%,which was lower than that in the control group (22.50%),the difference was statistically significant(P<0.05).The total nursing satisfaction of the observation group was 90.00%,which was significantly higher than that of the control group (72.50%),the difference was statistically significant(P<0.05).The nursing quality scores of the patients in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Risk awareness is very effective in the operation of the operating room,which is helpful to improve the surgical treatment effect,reduce the incidence of risk events,and improve patient care satisfaction.It is worth recommending.
2019 Vol. 26 (2): 229-231 [Abstract] ( 86 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
232 Nursing intervention in promoting early recovery of pelvic floor function in patients with pelvic floor dysfunction
HUANG Qi-ling
Objective To study the role of nursing intervention in promoting the early recovery of pelvic floor function in patients with pelvic floor dysfunction.Methods From May 2017 to January 2018,120 patients with pelvic floor dysfunction (PFD)treated in our hospital were selected and randomly divided into two groups,with 60 cases in each group.The experimental group treated with nursing intervention and the control group treated with routine nursing.The pelvic floor function recovery and other relevant indicators were compared between the two groups.Results Before nursing,there was no significant difference in the ratio of grade V muscle strength,uterine prolapse grade,stress urine incontinence and sexual satisfaction(P>0.05).After nursing,the ratio of muscle strength V(53.33%)in the experimental group was statistically higher than that in the control group (20.00%)(P<0.05).The incidence of uterine prolapse and stress urine incontinence in the experimental group was significantly lower than that in the control group(P<0.05).The sexual life satisfaction of the experimental group was much higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Nursing intervention can significantly promote the recovery of pelvic floor function in patients with PFD,increase patients′sexual life satisfaction,reduce the incidence of complications.
2019 Vol. 26 (2): 232-234 [Abstract] ( 83 ) HTML (32 KB)  PDF  (0 KB)  ( 15 )
235 Application effect of network interaction-based health education in maternal breastfeeding
ZHONG Yuan-shan;ZENG Hong
Objective To analyze the effect of network interaction-based health education on maternal breastfeeding.Methods A total of 100 puerperae from June 2017 to April 2018 in People′s Hospital of Longhua District,Shenzhen City were selected.According to different health education and nursing modes,they were divided into control group and observation group,50 cases in each group.In the control group,routine health education was used,while in the observation group,network interaction-based health education was adopted.The psychological status of puerperae,awareness rate of breastfeeding knowledge,breastfeeding compliance and satisfaction in the two groups were compared.Results The self-rating anxiety scale(SAS)and self-rating depression scale(SDS)scores of puerperae after health education in the observation group were lower than those in the control group (P<0.05).The awareness rate of breastfeeding knowledge in the observation group was 92.0%,higher than that of the control group accounting for 64.0%(P<0.05).The maternal breastfeeding compliance rate of the observation group was 98.0%,higher than that of the control group accounting for 82.0% (P<0.05).The total satisfaction from puerperae on health education was 100.0%,higher than that of the control group(86.0%).The differences mentioned above were all significant(P<0.05).Conclusion Network interactionbased health education has a remarkable effect on maternal breastfeeding care,which can significantly improve the maternal psychological state,and increase the maternal breastfeeding knowledge awareness,breastfeeding compliance and satisfaction,which is worthy of promotion.
2019 Vol. 26 (2): 235-237 [Abstract] ( 81 ) HTML (31 KB)  PDF  (0 KB)  ( 12 )
238 The effect of progressive rehabilitation nursing on the hope level and quality of life of discharged patients after radical gastrectomy
ZHENG Juan-xia;ZHENG Juan-li;ZHENG Juan-fen; HUANG Bi-fang;YANG Zheng-kun
Objective To evaluate the effect of progressive rehabilitation nursing on the hope level and quality of life of patients with gastric cancer after radical gastrectomy.Methods From May 2014 to May 2016,90 patients undergoing radical gastrectomy in our hospital were selected and divided into observation group(n=45)and control group(n=45)according to random number table method.The control group was given routine hospitalization health education,discharge guidance and follow-up plan,in the observation group,the gradual rehabilitation nursing intervention was added on the basis of the control group.The quality of life scale(QLQ-C30)and Herth Hope scale(HHI)were used to evaluate the level of hope and quality of life (QLQC-30)at 3 months,6 months and 9 months after discharge.The effect of progressive rehabilitation nursing on the level of hope and quality of life after radical gastrectomy were evaluated.Results The scores of positive attitude,intimate relationship and positive action in the observation group were significantly higher than those in the control group 3 months,6 months and 9 months after discharge (P<0.05).The scores of functional scale,general health status symptom score of the observation group were higher than those of the control group 3 months,6 months and 9 months after discharge from hospital,symptom score were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion The progressive rehabilitation nursing program can improve the quality of life of patients after radical gastrectomy and improve the level of hope after discharge,which is worthy of clinical application.
2019 Vol. 26 (2): 238-241 [Abstract] ( 90 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
242 Application effect of early rehabilitation nursing in stroke patients with hemiplegia
CHEN Jian-pu
Objective To explore the application effect of early rehabilitation nursing on stroke patients with hemiplegia.Methods Fifty stroke patients with hemiplegia who were admitted to our hospital from May 2017 to May 2018 were selected as the study subjects.According to different nursing methods,they were divided into experimental group (n=25)and control group(n=25).In the control group,traditional nursing was used,while in the experimental group,traditional nursing combined with early rehabilitation care was adopted.The Barthel index and Braden pressure sore risk score were compared between the two groups.Results After nursing,the Barthel index of the experimental group was higher than that of the control group,and the risk score of Braden pressure sore was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion Early rehabilitation care for stroke patients with hemiplegia can significantly alleviate negative emotions and improve limb function and living ability.
2019 Vol. 26 (2): 242-244 [Abstract] ( 64 ) HTML (30 KB)  PDF  (0 KB)  ( 17 )
245 Application effect of targeted preventive nursing in patients with gastrointestinal bleeding
ZHANG Yan
Objective To explore the application effect of targeted preventive nursing in patients with gastrointestinal bleeding.Methods Eighty patients with gastrointestinal hemorrhage admitted to our hospital from January 2017 to January 2018 were selected as the subjects.The patients were divided into control group and observation group according to random number table method,40 cases in each group.In the control group,routine nursing was used,while in the observation group,targeted preventive care was adopted.The clinical effect,hospital stay,and incidence of complications in the two groups were compared.Results The total effectiveness rate of patients with gastrointestinal hemorrhage in the observation group was 95.00%,higher than that in the control group accounting for 80.00%,with statistical significant(P<0.05).The total incidence of postoperative complications in the observation group was 7.50%,lower than that in the control group accounting for 27.50%,with statistical difference(P<0.05).The hospital stay of the patients in the observation group was shorter than that in the control group,with statistical difference (P<0.05).Conclusion For patients with gastrointestinal hemorrhage,early treatment and early prevention contribute to the reduction of the incidence of complications and prevent the occurrence of upper gastrointestinal bleeding due to stress,which is beneficial to the early recovery of patients.It is of great significance for the treatment of patients,and is worthy of recommendation.
2019 Vol. 26 (2): 245-247 [Abstract] ( 87 ) HTML (29 KB)  PDF  (0 KB)  ( 16 )
248 Application effect of individualized continuous nursing in patients with pneumoconiosis
HE Dan
Objective To explore the application effect of individualized continuous nursing in patients with pneumoconiosis.Methods Sixty patients with pneumoconiosis admitted to our hospital from February 2016 to April 2017 were selected as subjects.They were divided into control group (30 cases)and observation group (30 cases)according to computer randomization method.The control group was used routine care,the observation group was used personalized continuation care,the quality of life and lung function of the two groups were campared.Results The forced vital capacity(FVC),Forced Expiratory Volume in the first second(FEV1)and FEV1/FVC of the observation group were higher than those before the nursing(P<0.05).The FVC,FEV1and FEV1/FVC of the observation group were higher than those of the control group(P<0.05).The scores of physiological function,physiological function,vitality,general health,social function,mental health and emotional function were higher than those of the control group,and the somatic pain score was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion Individualized continuous nursing can effectively improve the lung function of patients with pneumoconiosis and improve the quality of life of patients.
2019 Vol. 26 (2): 248-250 [Abstract] ( 92 ) HTML (31 KB)  PDF  (0 KB)  ( 17 )
251 Application effect of emergency quality nursing in patients with acute myocardial infarction
LIU Ying
Objective To explore the effect of emergency high quality nursing in patients with acute myocardial infarction (AMI).Methods A total of 74 patients with AMI in our hospital from July 2016 to August 2017 were selected and divided into observation group and control group according to different nursing methods,37 cases in each group.The observation group were given high-quality nursing care and routine nursing was given in the control group.The hospital stay,bedridden time,incidence of complications and nursing satisfaction,the rate of thrombolysis recanalization and the time of intravenous thrombolysis of the two groups were compared and analyzed.Results The hospitalization time,bed rest time and intravenous thrombolysis time of the observation group were significantly shorter than those of the control group(P<0.05),the total incidence of complications was significantly lower than that of the control group(P<0.05),and the total nursing satisfaction and thrombolysis recanalization rate were significantly higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion Emergency high quality nursing in patients with AMI in the nursing effect is good,worthy of clinical promotion.
2019 Vol. 26 (2): 251-253 [Abstract] ( 84 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
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