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| Effect of combined treatment of Labetalol and Magnesium Sulfate on pregnancy outcome in patients with preeclampsia |
| XIE Fang |
| Department of Obstetrics,People′s Hospital of Xinyi City,Guangdong Province,Xinyi 525300,China |
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Abstract Objective To investigate the effect of combined treatment of Labetalol and Magnesium Sulfate on pregnancy outcome in patients with preeclampsia.Methods Altogether 210 patients with preeclampsia admitted to our hospital from August 2016 to March 2018 were selected as research objects and they were divided into the combined group and basic group according to the random number table method,with 105 cases in each group.The patients in the basic group were treated with Magnesium Sulfate alone,and the patients in the combined group were treated with Labetalol and Magnesium Sulfate.The therapeutic effect,pregnancy outcomes,adverse reactions,and blood pressure and urine protein quantitation before and after treatment were compared between the two groups.Results There were no significant differences in blood pressure(diastolic blood pressure,systolic blood pressure)and 24 h urine protein quantitation between the two groups before treatment(P＞0.05).The blood pressure and 24 h urine protein quantitation after treatment in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).The blood pressure and 24 h urine protein quantitation after treatment in the combined group were lower than those in the basic group,and the differences were statistically significant(P＜0.05).The total effective rate of treatment in the combined group was 96.2%,which was significantly higher than that in the basic group(78.1%),and the difference was statistically significant (P＜0.05).The incidence rates of uterine atony,premature delivery,fetal distress,neonatal asphyxia,postpartum infection,and postpartum hemorrhage in the combined group were lower than those in the basic group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P＞0.05).Conclusion Labetalol combined with Magnesium Sulfate is effective in treatment of patients with preeclampsia,and it can improve the pregnancy outcome of patients,which is worthy of clinical promotion.
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