时间调节诱导化疗联合调强放疗同期洛铂化疗治疗局部晚期头颈部鳞癌的效果

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (33 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical effect of combined time-modulated induction chemotherapy and intensity-modulated radiotherapy with concurrent lobaplatin chemotherapy in locally advanced head and neck squamous cell carcinoma.Methods Altogether 60 patients with locally advanced head and neck squamous cell carcinoma from April 2014 to April 2017 were selected and randomly divided into the observation group and the control group,30 cases in each group.The control group was treated with time-modulated induction chemotherapy.The observation group was treated with time-modulated induction chemotherapy and intensity-modulated radiotherapy combined with concurrent Lobaplatin chemotherapy.The incidence of adverse reactions,total effective rate,one-year overall survival rate,progression-free survival rate and local recurrence-free survival rate were compared between the two groups.Results The total effective rate of the observation group was 60.00%,which was higher than that of the control group(30.00%),with statistically significant difference (P＜0.05).The total incidence of adverse reactions of the observation group was 23.33%,compared with the control group(20.00%),there was no statistically significant difference(P＞0.05).The oneyear overall survival rate,progression-free survival rate and local recurrence-free survival rate of the observation group were 80.00%,60.00%and 56.67%respectively,which was higher than those of the control group(53.33%,33.33%and 30.00%),with statistically significant difference (P＜0.05).Conclusion Time-modulated induction chemotherapy combined with intensity-modulated radiotherapy combined plus concurrent Lobaplatin chemotherapy for locally advanced head and neck squamous cell carcinoma has a satisfactory effect with mild adverse reactions,which can be tolerated by patients and has clinical value.

Key words： Locally advanced head and neck squamous cell carcinoma Time-modulated induction chemotherapy Intensity-modulated radiotherapy Simultaneous Lobaplatin chemotherapy Treatment

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GUO Li-yi
	DENG Ming-hui
	LYU Li

Cite this article:

GUO Li-yi,DENG Ming-hui,LYU Li. Effect of time-modulated induction chemotherapy combined with intensity-modulated radiotherapy plus concurrent Lobaplatin chemotherapy in the treatment of locally advanced head and neck squamous cell carcinoma[J]. 中国当代医药, 2019, 26(2): 68-70.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I2/68

[1]	叶蕊，赵志飞，高灵灵，等.贝伐珠单抗联合同步放化疗在局部晚期头颈部鳞癌中的效果观察[J].解放军医学院学报，2016，37（9）：919-922.
[2]	王丽权，张立杰，孙继才，等.尼妥珠单抗联合奈达铂同步放化疗治疗晚期头颈部鳞癌临床观察[J].中国医师杂志，2016，18（10）：1564-1566.
[3]	王健仰，黄晓东，王凯，等.甘氨双唑钠降低头颈部鳞癌患者严重放射性黏膜炎的Ⅱ期随机临床研究[J].中华放射肿瘤学杂志，2016，25（7）：671-675.
[4]	邓坦，段华新.多西他赛联合奈达铂诱导化疗治疗局部晚期头颈部鳞癌的效果和不良反应观察[J].中国综合临床，2016，32（12）：1100-1102.
[5]	王天，丁浩，王胜资.诱导化疗在头颈部鳞状细胞癌中的应用[J].中国眼耳鼻喉科杂志，2018，18（1）：52-55.
[6]	罗以.局部晚期/远处转移的头颈部鳞癌的诊治策略[J].肿瘤药学，2016，6（1）：1-3.
[7]	杨亮，罗德红，易俊林，等.能谱参数预测局部晚期喉及下咽鳞癌治疗效果的探索性研究[J].中华放射肿瘤学杂志，2016，25（4）：310-314.
[8]	王兴，孟箭，李志萍，等.外放疗联合个体化导板辅助125I放射性粒子植入治疗晚期头颈部鳞癌[J].中华介入放射学电子杂志，2016，4（3）：132-135.
[9]	张余飞，温居一，康静波，等.SBRT治疗复发头颈部肿瘤的临床初步应用探讨[J].肿瘤学杂志，2016，22（10）：827-831.
[10]	陆雪官，胡超苏.头颈部鳞癌术后辅助放化疗的研究现状[J].中国癌症杂志，2017，27（6）：463-470.
[11]	李晓明，宋琦.同步放化疗在头颈部鳞状细胞癌治疗中应用的发展现状[J].中华耳鼻咽喉头颈外科杂志，2016，51（7）：545-549.
[12]	杨勇波.时辰诱导化疗序贯同步放化疗治疗局部晚期头颈部鳞癌的临床效果[J].中外医学研究，2017，15（12）：39-40.
[13]	胡章威，陈晨，汪雷，等.头颈部鳞状细胞癌相关肿瘤标志物的研究进展[J].现代生物医学进展，2016，16（25）：4984-4988.
[14]	张肖肖，张帆.局部晚期头颈部鳞癌术后同期放化疗与单纯放疗的效果比较[J].中国冶金工业医学杂志，2015，32（3）：295-296.
[15]	孟昭忠，李闯，王超.替吉奥胶囊联合尼妥珠单抗治疗晚期头颈部鳞癌的疗效观察[J].现代药物与临床，2017，32（11）：2212-2215.