口腔颌面部恶性肿瘤CCL-18、CyclinD1分子的检测意义

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Abstract Objective To explore the significance of CCL-18 and CyclinD1 in the detection of oral and maxillofacial malignant tumors.Methods Sixty four patients with oral and maxillofacial malignant tumors admitted to our hospital from February 2016 to February 2018 were selected as the analysis group,and 64 healthy volunteers at the same period were selected as the reference group,serum tests were performed in both groups.Routine examinations were performed once in the control group.The patients in the analysis group were tested before and 1 month after the treatment,preoperative serum levels of CCL-18 and CyclinD1 were compared between the two groups.The levels of CCL-18 and CyclinD1 in serum before and after operation,different pathological types,lymph node metastasis and different clinical stages were compared and analyzed.Results The levels of CCL-18 and CyclinD1 in serum of the analysis group before operation were higher than those of the control group,the differences were statistically significant(P＜0.05).The levels of CCL-18 and CyclinD1 in the serum of the analysis group at 1 month after operation were lower than those before operation,and the differences were statistically significant(P＜0.05).The level of CCL-18 in serum of patients without lymph node metastasis was significantly lower than that of patients with lymph node metastasis,the difference was significant(P＜0.05).The level of CCL-18 in serum of patients with stage II was significantly higher than that of patients with other 3 stages,the difference was significant(P＜0.05).The level of serum Cyclin D1 in patients with stage II was significantly lower than that in patients with other 3 stages,the difference was significant(P＜0.05).Conclusion Compared with healthy volunteers,the serum levels of CCL-18 and CyclinD1 in patients with oral and maxillofacial malignant tumors were significantly higher,which can be considered as an assistant diagnostic method for maxillofacial malignant tumors,and have a certain reference value.

Key words： CCL-18 CyclinD1 molecule Maxillofacial malignant tumor Auxiliary diagnosis

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	QI Xiao-yu
	AN Ying-jie

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QI Xiao-yu,AN Ying-jie. Detection significance of CCL-18 and CyclinD1 in oral and maxillofacial malignant tumors[J]. 中国当代医药, 2019, 26(2): 156-158转161.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I2/156

[1]	刘鹍鹏，李森森，华炜，等.CCL-18与CyclinD1分子在口腔颌面部恶性肿瘤患者血清中的变化及临床意义[J].肿瘤药学，2017，7（5）：586-590.
[2]	王蕊，李立恒，朱晓龙，等.涎腺腺样囊性癌中微血管密度与血管内皮生长因子的表达水平及临床意义[J].山西医药杂志，2017，46（22）：2749-2751.
[3]	王晓峰，张天夫，刘新，等.CD133基因启动子的克隆与序列分析[J].中国实验诊断学，2017，21（8）：1428-1429.
[4]	段红明，陈运美，吴汉江.口腔颌面部恶性肿瘤患者的营养状况评价[J].华西口腔医学杂志，2001，19（5）：300-302.
[5]	李晓，季彤.颌面头颈部骨肉瘤化学治疗的研究进展[J].国际口腔医学杂志，2017，44（1）：83-86.
[6]	李思源，郭雪生，单小峰，等.177例儿童口腔颌面部恶性肿瘤临床病理分析[J].中国口腔颌面外科杂志，2016，14（2）：134-139.
[7]	戴昱，汤剑明，冯力，等.老年口腔颌面部手术患者感染特征及炎症反应观察[J].中国医师杂志，2017，19（11）：1672-1675，1679.
[8]	姜啸，夏娟，程斌.趋化因子CCL18与肿瘤[J].国际肿瘤学杂志，2014，41（10）：724-726.
	（）（）
[9]	蒋李懿.细胞周期素D1及其编码基因CCND1与口腔黏膜癌变的关系研究[A]//广东省口腔医学会第三次会员代表大会暨第十次口腔医学学术会议[C].广州，2011.
[10]	邢劲松，史培荣，陈显久，等.细胞周期素D1在口腔鳞状细胞癌组织中的表达及意义[J].华西口腔医学杂志，2011，29（3）：299-301.
[11]	比力克孜·玉素甫，邝辉，田刚.MMP-2和CyclinD1在口腔鳞癌中表达的研究[J].右江医学，2011，39（2）：137-139.
[12]	张蓓.CyclinD1与P27在口腔鳞癌的表达及意义[J].医学理论与实践，2013，26（9）：1193-1194.
[13]	陈双艳，吴曦，余和东.国内口腔鳞癌患者肿瘤组织中CyclinD1 表达的 meta 分析[J].口腔医学，2014，34（9）：701-704.
[14]	何伟，陈欢，陈卫民.CyclinD1、Ki-67在口腔黏膜白斑和口腔鳞癌中的表达[J].河北联合大学学报（医学版），2016，18（2）：139-141，144.
[15]	罗锐，张睿智，龚正林，等.c-fos调控p16/CyclinD1信号途径并促进口腔鳞状细胞癌增殖和迁移[J].实用口腔医学杂志，2017，33（1）：100-104.