| [4] |
王红，杜娟，董亚琼.成人重症肺炎107例病原学分析[J].贵州医药，2015，39（4）：358-358.
|
| [9] |
Atkins D，Best D，Briss PA，et al.Grading quality of evidence and strength of recommendations[J].BMJ，2004，328（7454）：1490-1494.
|
| [16] |
Gao D，Li W.Structures and recognition modes of toll-like receptors[J].Proteins，2017，85（1）：3-9.
|
| [17] |
王耀辉，高丽丽，刘春样，等.溃疡性结肠炎患者Toll样受体2和转化生长因子-β水平变化及意义[J].中华实用诊断与治疗杂志，2017，31（1）：51-53.
|
| [1] |
Zhou J，Zhang X，Liu S，et al.Genetic association of TLR4 Asp299Gly，TLR4 Thr399Ile，and CD14 C-159T polymorphisms with the risk of severe RSV infection：a meta-analysis[J].Influenza Other Resp，2016，10（3）：224-233.
|
| [2] |
Nilsen NJ，Vladimer GI，Stenvik J.A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling[J].J Biol Chem，2015，290（6）：3209-3222.
|
| [3] |
Du B，Luo W，Li R，et al.Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression[J].J Biol Chem，2013，288（21）：15 131-15 141.
|
| [5] |
Iroh Tam PY，Thielen BK，Obaro SK，et al.Childhood pneumococcal disease in Africa-A systematic review and metaanalysis of incidence，serotype distribution，and antimicrobial susceptibility[J].Vaccine，2017，35（15）：1817-1827.
|
| [6] |
Moens L，Verhaegen J，Pierik M，et al.Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease[J].Microbes Infect，2007，9（1）：15-20.
|
| [7] |
Yuan FF，Marks K，Wong M，et al.Clinical relevance of TLR2，TLR4，CD14andFcgammaRIIAgenepolymorphismsin Streptococcus pneumoniae infection[J].Immunol Cell Biol，2008，86（3）：268-270.
|
| [8] |
Tellería-Orriols JJ，García-Salido A，Varillas D，et al.TLR2-TLR4/CD14 polymorphisms and predisposition to severe invasive infections by Neisseria meningitidis and Streptococcus pneumoniae[J].Med Intensiva，2014，38 （6）：356-362.
|
| [10] |
Corsini B，Aguinagalde L，Ruiz S，et al.Immunization with LytB protein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis[J].Vaccine，2016，34（50）：6148-6157.
|
| [11] |
Jaiswal N，Singh M，Thumburu KK，et al.Burden of invasive pneumococcal disease in children aged 1 month to 12 years living in South Asia：a systematic review[J].PLoS One，2014，9（5）：e96282.
|
| [12] |
Musie E，Moore CC，Martin EN，et al.Toll-like receptor 4 stimulation before or after Streptococcus pneumoniae induced sepsis improves survival and is dependent on T-cells[J].PLoS One，2014，9（1）：e86015.
|
| [13] |
Tomlinson G，Chimalapati S，Pollard T，et al.TLR-mediated inflammatory responses to Streptococcus pneumoniae are highly dependent on surface expression of bacterial lipoproteins[J].J Immunol，2014，193（7）：3736-3745.
|
| [14] |
Du B，Luo W，Li R，et al.Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression[J].J Biol Chem，2013，288（21）：15 131-15 141.
|
| [15] |
Guo T，Cai J，Peng Y，et al.Protective effect of an antibody against specific extracellular domain of TLR2 on agonistsdriven inflammatory and allergic response[J].Biomed Res Int，2016，（2016）：1-8.
|
| [18] |
Zeljic K，Supic G，Jovic N，et al.Association of TLR2，TLR3，TLR4 and CD14 genes polymorphisms with oral cancer risk and survival[J].Oral Dis，2014，20（4）：416-424.
|
| [19] |
Thorburn AN，Tseng HY，Donovan C，et al.TLR2，TLR4 and MyD88 mediate allergic airway disease（AAD）and Streptococcus pneumoniae-Induced suppression of AAD[J].PLoS One，2016，11（6）：e0156402.
|
| [20] |
H Zhang，L Kang，H Yao，et al.Streptococcus pneumoniae Endopeptidase O （PepO）Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 signaling pathways[J].Front Cell Infet Mi，2016，6：23.
|
