Objective To explore the drug compatibility and relevant medication rules in applications of Realgar in the treatment of sores and poison in ancient doctors.Methods Realgar prescriptions recorded in classic ancient books of Chinese ancient doctors were searched based on the "General Catalogue of Ancient Books on Chinese Medicine",so as to establish a relevant prescription database,and then,a statistical analysis on the frequency of drug use,four characters,five tastes,nature,flavor and channel tropism was conducted based on the database.Subsequently,the drug association rules and visual network diagrams were analyzed,so as to demonstrate the connections between drugs comprehensively.Finally,a cluster analysis was conducted to explore the classification of drugs for clinical use.Results A total of 459 prescriptions containing Realgar were included in the study,involving 480 kinds of drugs,and the accumulative times of medication reached 2980.There were 32 drugs with accumulative frequency ≥80%.In the prescriptions concerning Realgar,Cinnabar,Musk, Radix Aconite Lateralis Preparata,Alum,Croton and Bezoar were used for more than 60 times as high frequency drugs.For the nature and flavor,both warm and cold drugs were used,with pungent and sweet(light)flavors as the main.For channel tropism,liver,spleen,and heart meridians were dominant.The analysis on the drug association rules and visual network diagrams showed that the drug combination with the highest support was Realgar-Cinnabar,followed by Realgar-Musk.The cluster analysis results showed that high frequency drugs could be grouped into 5 categories.Conclusion A systematic analysis on the Realgar medication rules of ancient doctors for treating ulcer and carbuncle may be performed based on a data mining method,so as provide references for safe application of Realgar in modern clinical practice.

Objective To investigate the toxicity of Zedoary Turmeric Oil Cream on rats after long term continuous percutaneous administration and its safety of topical application.Methods Thirty Sprague Dawley(SD)female rats were randomly divided into 3 groups(blank control group,intact skin group and damaged skin group),10 rats in every group.Blank control group was administrated with blank cream matrix,intact skin group and damaged skin group were administrated with zedoary turmeric oil cream.After three months of continuous administration,the body weight,blood biochemical indicators(red blood cell[RBC],white blood cell[WBC],haemoglobin[HGB],neutrophil percentage[NEUT],platelet count[PLT],monocyte percentage[MONO],lymphocyte ratio[LYMPH],eosinophilic percentage[EO],basophile percentage[BASO])and blood biochemical indexes(aspartate aminotransferase[AST],aminotransferase[ALT],gamma-Glutamyl transferase[GGT],total bile acid[TBA],total bilirubin[TBil],preserum albumin[PA],urea,uric acid[UA],creatinine[Crea])were detected.Results Three months after the administration,the WBC of the damaged skin group were higher than that of the blank control group,and the HGB of the damaged skin group was lower than that of the blank control group,the PA of the damaged skin group were higher than that of the blank control group,and the differences were statistically significant(P<0.05).There were no significant differences of RBC,NEUT,PLT,MONO,LYMPH,EO,BASO,AST,ALT,GGT,TBA,TBil,Urea,UA,Crea among the three groups(P>0.05).Conclusion Zedoary Turmeric Oil Cream has no obvious long-term toxicity to experimental rats.

Objective To explore the application effect of Low Molecular Weight Heparin Calcium combined with Insulin pump in the treatment of hyperlipidemia pancreatitis.Methods A total of 56 patients with hyperlipidemia pancreatitis in the Department of Internal Medicine of the Second People′s Hospital of Panyu Guangzhou from September 2019 to September 2020 were selected as the research subjects,and they were divided into the control group and the study group by the random number table method,with 28 cases in each group.The control group was treated with fasting,fluid replacement,anti-inflammatory,Insulin and glucose,and the study group was treated with Insulin pump and Low Molecular Weight Heparin Calcium on this basis.The changes of activated partial thrombin time(APTT)and prothrombin time(PT)before and after treatment,the improvement time of abdominal distension after treatment,the improvement time of abdominal pain and the length of hospital stay,the levels of high-sensitivity C-reactive protein(hs-CRP),triacylglycerol(TG),D-dimer(D-D),white blood cell count(WBC)before treatment,4,7 days after treatment and treatment effects after days were compared between the two groups.Results There were no statistically significant differences in APTT and PT between the two groups before and after treatment(P>0.05).The improvement time of abdominal distension,abdominal pain,and length of hospital stay in the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The hs-CRP,TG,D-D,and WBC levels of the study group were lower than those of the control group after 4 and 7 days of treatment,and the differences were statistically significant(P＜0.05);The total treatment effective rate of the study group was higher than that of the control group,with statistical significance(P<0.05).Conclusion The combined application of Insulin pump and Low Molecular Weight Heparin Calcium in the treatment of hyperlipidemic pancreatitis has an ideal effect,which can reduce the hs-CRP,TG,D-D and WBC in the body,accelerate the improvement of symptoms,shorten the length of hospitalization,and thus improve the treatment effect.Therefore,it is worthy of promotion and application.

Objective To explore the effect of continuous positive airway pressure(CPAP)on oxygenation and intrapulmonary shunt in patients with one-lung ventilation by meta-analysis.Methods PubMed,Embase,VIP,CNKI,Wanfang Data and other databases were searched by computer.The search time was from the inception to 31 December 2020.Randomized controlled trials(RCTs)on the effect of CPAP administered on the non-ventilated side during one-lung ventilation on patients′ oxygenation status and intrapulmonary shunt were collected.Two independent researchers screened and extracted relevant literature,and evaluated the quality of literature following the inclusion and exclusion criteria.Finally,RevMan 5.3 software was used to conduct a meta-analysis on the included RCTs.Results A total of 11 RCTs and 346 patients were included.Intrapulmonary shunt volume in CPAP group(one-lung ventilation 30 min:SMD=-1.08,95%CI=-1.37 to -0.79, P<0.000 01;one-lung ventilation for 60 min: SMD=-0.47,95%CI=-0.83 to -0.12, P=0.009)was lower than that of the control group,and arterial partial oxygen pressure(one-lung ventilation for 30 min: SMD=0.97,95%CI=0.73-1.20, P<0.000 01;one-lung ventilation for 60 min: SMD=0.72,95%CI=0.30-1.13,P=0.0007),and the differences were statistically significant(P<0.05).There was no significant difference in the partial pressure of carbon dioxide between the two groups(one-lung ventilation for 30 min: SMD=0.02,95%CI=-0.24 to -0.29, P=0.87;one-lung ventilation for 60 min: SMD=-0.18,95%CI=-0.70-0.35, P=0.51).Conclusion CPAP can significantly improve the oxygenation status and intrapulmonary shunt in patients with one-lung ventilation.

Objective To explore the clinical effect of Mifepristone combined with Levonorgestrel intrauterine birth control system in the treatment of adenomyosis.Methods A total of 90 patients with adenomyosis who visited the department of gynaecology in Nantong Tongzhou People′s Hospital from January 2018 to January 2020 were selected as the research subjects.According to random number table method,they were divided into control group and observation group,with 45 cases in each group.The control group was treated with Mifepristone,and the observation group was treated with Mifepristone combined with Levonorgestrel intrauterine birth control system.Menstrual volume,uterine condition,levels of follicle generating hormone(FSH),estradiol(E2)and luteinizing hormone(LH)in two groups before and after treatment were compared.Visual analogue scale(VAS)was used to evaluate dysmenorrhea.The incidence of adverse reactions in two groups during treatment was compared.Results Before treatment,there was no significant difference in menstrual volume and VAS score between two groups(P>0.05).After treatment,the menstrual volume of the observation group was less than that of the control group,and the VAS score of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in uterine volume and endometrial thickness between two groups(P>0.05).After treatment,endometrial thickness and uterine volume in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before and after treatment,there were no significant differences in FSH,E2 and LH between two groups(P>0.05).There was no statistical significance in the total incidence of adverse reactions between two groups(P>0.05).Conclusion Mifepristone combined with Levonorgestrel intrauterine birth control system can relieve the degree of dysmenorrhea and reduce menstrual volume in patients with adenomyosis and meanwhile will not cause hormone level fluctuations and increase the incidence of adverse reactions.The effect is remarkable and it is worthy of promotion.

Osteonecrosis of the femoral head(ONFH)is one of the most common refractory diseases in orthopedics,which seriously affects the quality of life of patients.Traditional Chinese medicine classifies ONFH as "bone erosion""bone atrophy" "bone paralysis" and so on.Under the guidance of the holistic concept and treatment based on syndrome differentiation,traditional Chinese medicine treats ONFH according to the symptoms and signs in clinic,the invention has the unique advantages of strong individuality,high safety,few adverse reactions and quick curative effect.Through reading and discussing the present situation of diagnosis and treatment of ONFH and the differentiation of symptoms and signs and other literature materials in the treatment of ONFH with traditional Chinese medicine in recent years,this article summarizes the application research progress of traditional Chinese medicine syndrome differentiation treatment methods in ONFH,with a view to provide a scientific reference for the traditional Chinese medicine diagnosis of ONFH and the selection of prescriptions according to the methods.

Rectus abdominis,as an important part of the core muscle group of human abdomen,can protect abdominal organs,maintain and increase intraabdominal pressure,and participate in physiological activities such as defecation,vomiting,cough and delivery.When the left and right rectus abdominis muscles are abnormally separated from the abdominal white line to both sides,and the distance between them is greater than 2 cm,the clinical diagnosis is diastasis recti abdominis.Diastasis recti abdominis is a kind of connective tissue damage,which mainly occurs in 30% to 68%of postpartum women.At present,the widening of rectus abdominis internal spacing is used as an index to measure the severity of diastasis recti abdominis at home and abroad.Imaging examinations such as ultrasound,CT and MRI can directly show the separation distance of rectus abdominis and the pathological changes of the surrounding tissue,which plays an important role in making clinical treatment plan and evaluating the effect of treatment.This study reviews the risk factors,clinical manifestations,treatment and imaging diagnosis of diastasis recti abdominis.

Objective To investigate the judgment value of the central venous-to-arterial carbon dioxide difference(Pcv-aCO2)on the prognosis of traumatic hemorrhagic shock(THS).Methods A retrospective analysis of the clinical data of 60 patients with THS admitted to the First Affiliated Hospital of Gannan Medical College from May 2019 to September 2020.According to the outcome,they were divided into the survival group(36 cases)and the death group(24 cases).The levels of Pcv-aCO2,central venous blood oxygen saturation(ScvO2),central venous pressure(CVP),base excess(BE),blood lactic acid and acute physiology and chronic health evaluation(APACHEⅡ)score between the two groups were compared.To evaluate the judgment value of Pcv-aCO2 detection,ScvO2 detection,Pcv-aCO2 combined with ScvO2 detection on the prognosis.Results Six hours after resuscitation,the levels of Pcv-aCO2 and blood lactic acid of the survival group were lower than those of the death group,the levels of ScvO2 and BE of the survival group were higher than those of the death group,the differences were statistically significant(P<0.05).There were no statistically significant of CVP levels and APACHEⅡscore between the two groups(P>0.05).The levels of Pcv-aCO2 and blood lactic acid at six hours after resuscitation were lower than those before resuscitation in the survival group,and the levels of ScvO2 and BE at six hours after resuscitation were higher than those before resuscitation in the survival group,with statistically differences(P<0.05).There were no statistically significant of CVP levels before and after resuscitation in the survival group(P<0.05).The judgment value the prognosis was the highest of Pcv-aCO2 combined with ScvO2 detection on the prognosis(Pcv-aCO2 combined with ScvO2 detection vs. Pcv-aCO2 detection: Z=2.291, P<0.05;Pcv-aCO2 combined with ScvO2 detection vs.ScvO2 detection: Z=2.144, P<0.05),and the sensitivity and specificity were 85.71% and 82.69%,its better than the ScvO2 detection and Pcv-aCO2 detection.Conclusion Early detection of Pcv-aCO2 combined with ScvO2 could accurately judgment the prognosis of patients with THS,it has important clinical guiding value.

Objective To discuss the application of percutaneous dilated tracheotomy guided by ultrasound and fiberoptic bronchoscopy in ICU patients.Methods A total of 60 ICU patients admitted to Fuzhou First People′s Hospital from August 2019 to August 2020 were selected as the research objects and divided into control group(30 cases)and test group(30 cases)according to the random number table method.The control group received percutaneous dilated tracheotomy guided by fiberoptic bronchoscopy,and the test group received percutaneous dilated tracheotomy guided by ultrasound.Compare the two groups of surgery-related indicators and the occurrence of complications.Results After comparison,the operation time of the test group was shorter than that of the control group,the amount of blood loss and the number of cases of airbag leakage during tracheal intubation were less than those of the control group,and the operation cost was lower than that of the control group ,the difference was statistically significant(P<0.05).There were no significant differences in the incidence of complications such as postoperative bleeding,intraoperative hypoxemia,posterior tracheal wall injury,sputum from incision,the total incidence and extubation time between the two groups(P>0.05).Conclusion Ultrasound-guided percutaneous dilatation tracheotomy is effective in the treatment of ICU patients.It can

Objective To investigate the application of individualized prescription diet in pulmonary tuberculosis patients with diabetes.Methods A total of 80 cases of newly treated pulmonary tuberculosis patients with type 2 diabetes who were admitted to the four departments of Jiangxi Chest Hospital from February 2019 to December 2019 were selected as the research objects,according to the random number table method,they were divided into the control group(n=40)and the experimental group(n=40).The control group was guided by regular diet,experimental group received individualized diet prescription,all patients were followed up by telephone after discharge were followed up for 3 months..The two groups of patients were compared with whole blood fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PG)and glycosylated hemoglobin(HbA1c)levels,clinical symptoms and imaging indicators before admission and 3 months after discharge.Results The levels of whole blood FBG,2 h PG,HbA1c and the clinical symptom scores of cough and sputum in the treatment group were lower than those in the control group 3 months after discharge,the differences were statistically significant(P＜0.05).The lesion closure rate in the experimental group was higher than that in the control group 3 months after discharge,no change rate was lower than the control group,the differences were statistically significant(P＜0.05).Conclusion Individualized dietary prescriptions are better than conventional dietary guidance in controlling blood glucose levels in patients with diabetes and tuberculosis,and the efficacy of anti-TB drugs can play a normal,control the development of tuberculosis.

Objective To investigate the clinical effect of mouse nerve growth factor(mNGF)combined with mecobalamine in the treatment of peripheral neuropathy(PN)in hemodialysis patients.Methods Fifty-four hemodialysis patients with PN who were admitted to the Affiliated Hospital of Jiujiang University from August 2019 to August 2020 were selected and divided into two groups according to the random number table method,with 27 patients in each group.Both groups were treated with routine hemodialysis.The control group was additionally treated with mecobalamin for 4 weeks,and the observation group was treated with mNGF based on the control group,both groups were treated for 4 weeks.Clinical efficacy,nerve conduction velocity and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.30%,which was higher than that of the control group(70.37%),and the difference was statistically significant(P<0.05).No significant difference was observed in nerve conduction velocity between the two groups before treatment(P>0.05).After treatment,the motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of median nerve,common peroneal nerve and sural nerve in both groups were higher than those before treatment in the group,with statistically significant differences(P<0.05).MNCV and SNCV of median nerve,common peroneal nerve and sural nerve in the observation group were higher than those in the control group after treatment,and the differences were statistically significant(P<0.05).No significant difference was observed in the total incidences of adverse reactions between the two groups(P>0.05).Conclusion The mNGF combined with mecobalamine can enhance the treatment effect of PN in hemodialysis patients,improve nerve conduction velocity,and promote the disappearance of clinical symptoms,which is safe and reliable.

Objective To investigate fractional exhaled nitric oxid(FeNO)of patients with severe obstructive sleep apnea and hypopnea syndrome(OSAHS)and its correlation with Krebs Von den Lungen-6(KL-6).Methods From January 2017 to December 2018,a total of 70 patients with severe OSAHS admitted to the Second People′s Hospital of Guangdong Province were selected as the experimental group,and seventy healthy persons in the same period were selected as the control group.The body mass index(BMI),apnea-hypopnea index(AHI),lowest oxygen saturation(LSaO2),KL-6 and FeNO levels of the two groups were compared,and the FeNO correlation with BMI,AHI,LSaO2,KL-6 were analysed.Results The level of BMI and AHI in the experimental group was higher than those in the control group,and the level of LSaO2 was lower than that in the control group,the differences were statistically significant(P<0.05).The levels of KL-6 and FeNO in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).FeNO level was positively correlated with BMI,AHI and KL-6(r=0.43,0.57,0.37, P<0.05).There was a negative correlation between FeNO and LSaO2(r=-0.49, P<0.05).Conclusion The levels of KL-6 and FeNO in patients with severe OSAHS increased,and the levels of FeNO were positively correlated with AHI and KL-6,and negatively correlated with LSaO2.It is suggested that FeNO is related to the severity of the disease and can be used as an index to evaluate the disease.

Objective To investigate the effect of cryoprecipitation in perioperative period of patients with portal hypertension(PHT)of liver cirrhosis.Methods A total of 86 patients with cirrhosis and PHT who were admitted to the Yichun People′s Hospital in Jiangxi Province from August 2018 to December 2019 were selected as the research objects.They were divided into the control group(43 cases)and the observation group(43 cases)according to the random lottery method.The control group was given blood components such as inactivated frozen plasma and leukocyte-free suspended red blood cells during the perioperative period,and the observation group was given cryoprecipitate during the perioperative period.The coagulation function,medical expenses,amount of leukocyte-removed suspended red blood cell in 24 hours,and hospital stay were compared between the two groups.Results The postoperative plasma prothrombin time(PT)24 hours after infusion,activated partial thromboplastin time(APTT),thrombin time(TT),and D-Dimer(D-Dimer,D-D)level were lower than the control group,and the fibrinogen(FBG)level was higher than that of the control group,the differences were statistically significant(P＜0.05).The medical expenses and the amount of leukocyte-removed and suspended red blood cells in 24 hours of the observation group were less than those of the control group,the hospital stay was shorter than the control group,the differences were statistically significant(P<0.05).Conclusion The application of cryoprecipitation in cirrhosis patients with portal hypertension during perioperative period can improve the coagulation function of patients,reduce medical costs and shorten the length of hospital stay,which is worthy of promoting.

Objective To analyze the application effect of integrated trauma emergency mode in surgical severe trauma emergency.Methods A total of 120 patients with severe surgical trauma admitted to the emergency department of Huizhou Huiyang Sanhe Hospital from December 2018 to December 2019 were selected as the research objects and divided into the control group and the observation group according to random numble table method,with 60 cases in each group.The control group received conventional emergency mode intervention,and the observation group received integrated trauma emergency mode intervention.The treatment success rate,emergency response time,coma status(Glasgow coma score[GCS])and trauma degree(abbre viated injury scale-injury severity score[AIS-ISS])were compared between the two groups.Results The success rate of treatment in the observation group was 86.87%,higher than 68.33%in the control group,and the difference was statistically significant(P<0.05).The stay time in the emergency room,the time spent in special examination,the time between emergency and operation,the time between admission and operation in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Before emergency treatment,there were no significant differences in GCS and AIS-ISS scores between the two groups(P>0.05).After emergency,the GCS scores of the two groups were higher than those before emergency,the AIS-ISS scores of the two groups were lower than those before emergency,and the differences were statistically significant(P<0.05).After emergency,the GCS score of the observation group was higher than that of the control group,the AIS-ISS score of the observation group was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion The integrated trauma emergency mode has a significant effect on surgical patients with severe trauma,which can significantly shorten the emergency response time,improve the success rate of treatment,and improve the doctor-patient relationship and the quality of life of patients.

Objective To compare the clinical efficacy of Dapagliflozin and Linagliptin in the treatment of overweight or obese patients with type 2 diabetes mellitus(T2DM)with microalbuminuria.Methods A total of 58 patients diagnosed as overweight or obese with T2DM with microalbuminuria at the Seventh People′s Hospital of Nanhai District,Foshan City,Guangdong Province from April 2019 to April 2020.According to the random number table,they were divided into Dapagliflozin group and Linagliptin group,with 29 cases in each group.Both groups were treated with Metformin for basic treatment.Blood glucose related indexes,insulin resistance index,renal function related indexes and adverse reactions were compared between the two groups.Results The fasting blood glucose(FPG),2 h postprandial glucose(2 h PG)and glycosylated hemoglobin(GHb)after treatment in the two groups were lower than those before treatment,the FPG,2 h PG and GHb in the Dapagliflozin group after treatment were lower than those in the Linagliptin group,and the differences were statistically significant(P<0.05).After treatment,the insulin resistance index of the two groups was lower than that before treatment,and the insulin resistance index of the Dapagiflozin group was lower than that of the Linaliptin group,and the differences were statistically significant(P<0.05).Urinary microalbumin(UAlb),urine albumin/creatinine ratio(UACR),and serum creatinine(SCr)after treatment in the two groups were lower than those before treatment,the UAlb,UACR and SCr of the Dapagliflozin group after treatment were lower than those of the Linagliptin group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Dapagliflozin can effectively improve the blood sugar of overweight or obese patients with T2DM with microalbuminuria,lower their insulin resistance index and improve their renal function,and reduce the incidence of adverse reactions.

Objective Use the handheld gauge to measure the pressure in the cuff of the tracheal tube intermittently,to analyze the deviation of the measure value and the actual value of the cuff pressure in different target,and to provide references for the use.Methods The experiment used self-match design,compared the difference between the measure value and the actual value by the traditional method and the improved method.Traditional manometry simulated artificial airway through the tracheal intubation model.The handheld gauge was used to measure the pressure in the cuff of the tracheal tube intermittently.Under different target pressures 30,28,26 cmH2O,recorded as traditional group 1,traditional group 2 and traditional group 3,the handheld gauge and the air bag were quickly separated,and then connected again to get the measurement value and the loss value,each group was repeated 120 times.Improved manometry while the airbag pressure was 30 cmH2O,connected medical tee to the pressure gauge,adjusted the tee switch to 45°,and after inflated to 30 cmH2O,connected the airbag and the tee,then turn the tee ,got the pressure value and the loss value.Results The measurement values of traditional group 1,traditional group 2 and traditional group 3 were(23.27±0.88),(21.15±0.83)and(17.63±1.28)cmH2O,the target pressure and measured value of three groups were compared,the differences were with highly statistically significant(P＜0.01).There was no statistically significant of pressure loss value between the traditional group 1 and the traditional group 2(P＞0.05).The pressure loss value of the traditional group 1 was lower than that of the traditional group 3,the difference was statistically significant(P＜0.05),the pressure loss value of the traditional group 2 was lower than that of the traditional group 3,the difference was statistically significant(P＜0.05).The pressure loss value of the improve pressure measuring group was lower than that of the traditional group 1,the difference was statistically significant(P＜0.05).The measured value of the improve pressure measuring group was(29.48±0.45)cmH2O,within the target pressure range.Conclusion The pressure loss by traditional manometry is obvious.The improve pressure manometry by tee can effectively reduce the pressure loss.

Objective To investigate the efficacy and safety of Kudanwan combined with Acitretin Capsules in the treatment of psoriasis vuIgaris.Methods A total of 200 patients with psoriasis vuIgaris admitted to the Seventh People′s Hospital of Shenyang from October 2019 to October 2020 were selected as the research objects.They were divided into observation group(100 cases)and control group(100 cases)by random drawing method.The observation group was treated with Kudanwan combined with Acitretin Capsules,and the control group was treated with conventional treatment.The total effective rate,levels of inflammatory factors,incidence of adverse reactions and immune function of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,interleukin-6,interleukin-8,tumor necrosis factor-α of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).IgG,IgA,IgM,C3,C4 of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion Kudanwan combined with Acitretin Capsules has A remarkable effect and high safety.

Objective To explore the application of Alprostadil combined with Pantoprazole Sodium in the treatment of patients with acute pancreatitis.Methods A total of 58 patients with acute pancreatitis in the Department of Gastroenterology of the First the People′s Hospital of Changshu City from February 2018 to February 2020 were selected as the research objects and divided into the control group and the study group according to random number table method,with 29 cases in each group.The control group was treated with Pantoprazole Sodium,and the study group was treated with Alprostadil combined with Pantoprazole Sodium.The negative conversion rate of blood amylase,the rate of relief or disappearance of signs,the rate of relief or disappearance of symptoms,the clinical effect and the hemodynamic indexes were compared between the two groups after 5 and 10 days of treatment.Results The blood amylase negative conversion rate,sign remission or disappearance rate,symptom remission or disappearance rate of the study group were higher than those of the control group at 5 and 10 days after treatment,and the differences were statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The cerebrovascular resistance(CVR),mean arterial pressure(MAP)of the study group after treatment were higher than those of the control group,and the heart rate(HR)was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion Compared with Pantoprazole Sodium alone,Proprostadil combined with Pantoprazole Sodium in the treatment of acute pancreatitis can better relieve the signs and symptoms of patients,improve the hemodynamics,have more significant therapeutic effect,have higher application value,and are worthy of clinical promotion.

Objective To investigate the effect of sputum aspiration through fiberbronchoscope combined with alveolar lavage in the treatment of aspiration pneumonia and its influence on lung function.Methods A total of 80 patients with aspiration pneumonia admitted to Yifu Hospital Affiliated to Nanjing Medical University from March 2017 to June 2020 were selected as the research objects.According to the principle of random drawing,they were divided into the observation group(40 cases)and the control group(40 cases).The control group was treated with conventional treatment,and the observation group was treated with sputum aspiration through fiberbronchoscope combined with alveolar lavage.The improvement of symptom,total effective rate,total incidence of adverse reactions and pulmonary function indexes were compared between the two groups.Results The temperature recovery time,rales disappearance time,cough disappearance time,antibiotic use time,erythrocyte sedimentation rate recovery time and hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,with statistical significance(P<0.05).The forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and peak expiratory flow(PEF)in the observation group after treatment were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The effect of sputum aspiration through fiberbronchoscope combined with alveolar lavage in the treatment of aspiration pneumonia is very significant,without increasing obvious adverse reactions,which can improve the lung function index of patients.

Objective To investigate the effect of ultrasound guided stellate ganglion pulsed radiofrequency in the treatment of scapulohumeral periarthritis.Methods A total of 60 patients with scapulohumeral periarthritis admitted to People′s Hospital of Shangrao City in Jiangxi Province from January 2019 to December 2020 were selected as the research objects and divided into ultrasound group and routine group according to random number table method,with 30 cases in each group.The ultrasound group received continuous pulsed radiofrequency treatment of stellate ganglion under ultrasound guidance after lidocaine block,and the routine group received lidocaine planetary ganglia block(SGB)treatment.The shoulder joint pain and shoulder joint function were compared between the two groups at different time points.Results At 1,2,3 and 4 weeks after treatment,the shoulder pain scores in the ultrasound group were lower than those in the routine group,and the differences were statistically significantly(P<0.05).At 1,2,3 and 4 weeks after treatment,the shoulder function joint scores in the ultrasound group were higher than those in the routine group,and the differences were statistically significantly(P<0.05).Conclusion Ultrasound-guided stellate ganglion pulsed radiofrequency therapy can effectively relieve the pain of scapulohumeral periarthritis and improve the shoulder joint function,which is worthy of clinical promotion.

Objective To investigate the clinical effect of free peroneal perforator flap in repairing the wound of infective ulcer of foot.Methods A total of 60 patients with foot infectious ulcer wounds admitted to Nanchang First Hospital from September 2018 to October 2019 were selected as the research subjects and divided into control group(30 cases)and treatment group(30 cases)according to random number table method.The control group used pedicle flap repair,the treatment group was repaired with free peroneal artery perforator flap.The recovery of the skin flap,the sensory function of the skin flap and the foot function scores before and after operation were compared between the two groups.Results Twelve months after operation,there was no significant difference in the recovery of skin flap between two groups(P>0.05).The recovery rate of sensory function of flaps in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in American orthopaedic foot and ankle society(AOFAS)scores and AOFAS functional scores between the two groups before surgery(P>0.05).At 12 months after surgery,the AOFAS score and AOFAS functional score in both groups were higher than those before surgery,and the AOFAS score and AOFAS functional score in treatment group were higher than those in control group,the differences were statistically significant(P<0.05).Conclusion Free peroneal artery perforator flap for repairing foot infection and ulcer wound with reliable blood supply,moderate thickness,sensory function recovery after surgery is better,and good prognosis,can effectively restore the patient's foot function level.

Objective To investigate the clinical effect of Sanqi Huoxue Jiegu Capsules in the treatment of patients with distal radius fracture(DRF).Methods A total of 70 DRF patients treated in Hongdu Hospital of Traditional Chinese Medicine of Nanchang City from April 2019 to June 2020 were selected and divided into two groups by random number table method,with 35 patients in each group.The control group was treated with manual reduction and small splint external fixation,and the observation group was treated with Sanqi Huoxue Jiegu Capsules on this basis.The clinical efficacy,wrist function,pain degree,swelling degree and complications of the two groups were compared.Results The total clinical effective rate of observation group(94.29%)was higher than that of control group(74.29%),and the rate of excellent and good of wrist function in observation group(88.57%)was higher than that of control group(68.57%),with statistically significant differences(P<0.05).After treatment,the wrist swelling score and pain visual analogue scale(VAS)of the observation group were(0.55±0.24)and(1.72±0.14)points,which were lower than those of the control group of(0.98±0.27)and(2.04±0.20)points,with statistical significances(P<0.05).The total incidence of complications in the observation group(5.71%)was lower than that in the control group(22.86%),and the difference was statistically significant(P<0.05).Conclusion The treatment of DRF patients with Sanqi Huoxue Jiegu Capsules can relieve the swelling and pain of the affected limbs,reduce the incidence of complications,promote the recovery of wrist joint function,and accelerate the recovery process of the patients.

Objective To analyze the clinical value of platelet-rich plasma(PRP)in knee osteoarthritis.Methods A total of 70 patients with knee osteoarthritis admitted to the Department of Orthopedics of Shangrao Municipal Hospital from January 2019 to June 2020 were selected and divided into the control group(n=35)and the observation group(n=35)according to the random number table method.The control group were treated with sodium hyaluronate,and the observation group were treated with PRP.The knee joint function and pain degree were compared between the two groups.Results Before treatment,there were no statistically significant differences in the Lequesne Algofunctional index(Lequesne)score,visual analog scale(VAS)score,and the western Ontario and McMaster Universities osteoarthritis index(WOMAC)score between the two groups(P>0.05).The Lequesne score,VAS score,and WOMAC score of the observation group were lower than those of the control group at 1,3,and 6 months after treatment,with statistically significant differences(P<0.05).The Lequesne score,VAS score,and WOMAC scores at 1,3,and 6 months after treatment were lower than those before treatment in this group,with statistically significant differences(P<0.05).Conclusion PRP is effective in the treatment of knee osteoarthritis,which can improve knee joint function and degree of osteoarthritis,relieve pain,and promote recovery of patients.

Objective To investigate the application effect of endoscopic fenestration of intervertebral disc(ENDO-LOVE)and percutaneous endoscopic interlaminar discectomy(PEID)in the treatment of patients with lumber disc herniation(LDH)of L5-S1.Methods A total of 119 patients with intervertebral disc herniation of L5-S1 admitted to the First People′s Hospital of Shaoguan from January 2017 to January 2020 were selected and divided into the study group(60 cases)and the control group(59 cases)according to the random number table method.The study group received ENDOLOVE operation,and the control group received PEID operation.Procalcitonin(PCT),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),visual analogue scale(VAS)scoring at 1,2,3,24 and 48 hours after operation,Japanese orthopaedic association assessment treatment(JOA)score at 1 day before operation and 1 month after operation,and the incidence of complications were compared between the two groups.Results One day before operation,PCT and TNF-α levels of the two groups were compared,there were no significant differences in CRP level and JOA scores(P>0.05).On the 10th day after operation,CRP in the study group was lower than that in the control group(P<0.05),while JOA scores of upper limb and sensory function were higher than those in the control group(P<0.05).There was no significant difference between the two groups(P>0.05).There was no significant difference in the total complication rate between the two groups(P>0.05).Conclusion Compared with PEID,ENDO-LOVE has higher stability in the treatment of LDH in L5-S1 vertebrae,better recovery of cervical spine function and lower changes of serum inflammatory factors.

Objective To compare the clinical effect of percutaneous lateral foraminal endoscopy and posterior fenestration in the treatment of lumbar disc herniation(LDH).Methods From January 2019 to January 2020,60 patients with LDH admitted to the Department of Orthopedics,Leping Hospital of Traditional Chinese Medicine,Jiangxi Province were selected as the research objects.According to the random number table method,they were divided into control group(30 cases)and study group(30 cases).Patients in the control group underwent posterior fenestration,and patients in the study group underwent percutaneous lateral foraminal endoscope.The surgical indexes,the total incidence of postoperative complications and the surgical results were compared between the two groups.The pain and lumbar dysfunction before and after surgery were compared between the two groups.Results The incision length,operation time and postoperative hospital stay in the study group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group,with statistically significant differences(P<0.05).The total incidence of postoperative complications in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the rate of the excellent and good of operation between the two groups(P>0.05).There was no significant difference in pain visual analogue scale(VAS)and Oswestry disability index(ODI)scores before and after surgery between the two groups(P>0.05).The VAS and ODI scores at one month after surgery in the two groups were lower than those before surgery,with statistically significant differences(P<0.05).Conclusion Posterior lamina fenestration and percutaneous lateral foraminal endoscopy have similar surgical effects in patients with LDH,but the latter has less trauma to patients and fewer postoperative complications,it is recommended as the first choice.

Objective To explore the clinical effect of arthroscopic internal fixation with threaded anchors in the treatment of posterior cruciate ligament fractures.Methods A total of 80 patients with posterior cruciate ligament anchorage fractures admitted to Yingtan Medical District,No.908 Hospital of Joint Logistic Support Force of Chinese People′s Liberation Army from June 2019 to June 2020 were selected.According to the random number table method,they were divided into control group and experimental group,40 cases in each group.Patients in the control group underwent conventional rouge socket wire fixation,and patients in the experimental group received arthroscopic internal fixation with wire anchors.Patients in both groups were followed up for 6 months.Operation-related indexes and postoperative clinical efficacy were compared between the two groups.The functional recovery before and 6 months after surgery of the two groups was compared.Results The operation time and the healing time of the Ⅰincision in the experimental group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group,with statistical significances(P<0.05).Before surgery,there was no significant difference in Lysholm score between the two groups(P>0.05).At 6 months after surgery,Lysholm scores in the two groups were higher than those before surgery,the differences were statistically significant(P<0.05).At 6 months after surgery,Lysholm score in the experimental group was higher than that in the control group,and the total effective rate in the experimental group(92.50%)was higher than that in the control group(72.50%),with statistical significances(P<0.05).Conclusion Arthroscopic internal fixation with threaded anchors can significantly reduce the clinical symptoms of patients with posterior cruciate ligament attachment fractures,promote joint function recovery,and have a significant effect.

Objective To investigate the effect of conventional rehabilitation combined with electroacupuncture training on postoperative rehabilitation of patients with arthroscopic rotator cuff injury.Methods Ninety-two patients who underwent arthroscopic rotator cuff injury repair at the Northern Theater General Hospital from September 2017 to March 2020 were selected as the research objects,and were divided into the control group and the observation group according to the random number table,with 46 patients in each group.The control group received conventional rehabilitation training,and the observation group received conventional rehabilitation training combined with electroacupuncture.The total effective rate of treatment and visual analog scale(VAS)score were compared between the two groups.The American Association of Shoulder and Elbow Physicians score(ASES)and Constant-Murley score(CMS)were used to evaluate the shoulder function of the patients,and the range of motion in flexion,abextension and extension of the shoulder joint was measured.Quality of life scale(SF-36)was used to evaluate patients′ quality of life after treatment.Results The total effective rate of the observation group(93.48%)was higher than that of the control group(76.09%),and the difference was statistically significant(P<0.05).There was no significant difference in VAS scores between the two groups before treatment(P>0.05).VAS scores in the observation group were lower than those in the control group at 7,14 and 12 weeks of treatment,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in shoulder ASES and CMS scores between the two groups(P>0.05).After 14 d and 12 weeks of treatment,the ASES and CMS scores of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the range of motion of shoulder between the two groups(P>0.05)After treatment,the range of motion of shoulder flexion,abduction and extension in observation group was higher than that in control group,and the differences were statistically significant(P<0.05).After treatment,the scores of social function,emotional function,physiological function,physical pain,mental health,general health and vitality in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Rehabilitation training after repair of rotator cuff injury is very important.Electroacupuncture on the basis of conventional training can relieve pain,improve shoulder joint function,and consolidate the effect of rehabilitation training.

Objective To study the effect of modified lateral superior malleolar perforator flap in the treatment of soft tissue defect after calcaneus operation.Methods A total of 86 patients with soft tissue defect after calcaneal surgery admitted to the Department of Orthopedics in the Third People′s Hospital of Jingzhou City,Hubei Province from January 2018 to January 2019 were selected as the research objects.According to the random number table method,they were divided into the control group and the study group,with 43 patients in each group.Patients in the control group were treated with traditional flap repair,and patients in the study group were treated with modified lateral supramolleolar perforator flap repair.The incidence of complications,heel shape score at 12 months and postoperative indexes were compared between the two groups.Results There was no significant difference in the total incidence of complications between the study group(6.98%)and the control group(11.63%)(P>0.05).There were no significant differences between the study group and the control group in flap color and flap temperature scores of heel shape score at 12 months after surgery(P>0.05).The scores of local scar and wound healing in the study group of heel shape score at 12 months after surgery were lower than those in the control group,and the differences were statistically significant(P<0.05).The duration of swelling relief and pain relief in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Conclusion When the modified superior perforator flap is used to repair the soft tissue defect after calcaneal surgery,it can obtain the ideal repair effect,reduce the complications,alleviate the pain and swelling of the patients,and shorten the hospital stay,it is worth popularizing and applying.

Objective To investigate the expression of NF-κB p65 protein in skin squamous cell carcinoma.Methods The pathological sections of 50 patients with skin squamous cell carcinoma treated in the Affiliated Hospital of Guizhou Medical University and the First Affiliated Hospital of Gannan Medical University from January 2018 to December 2019 were selected as cancer tissue group,and 50 cases of paracancerous tissue was selected as control group.The expression of NF-κB p65 protein was compared between the two groups.The relationship between the expression of NFκB p65 protein in skin squamous cell carcinoma and the patient′s gender,age,clinical stage and degree of differentiation was analyzed.Results The positive rate of NF-κB p65 protein expression in the cancer tissue group was higher than that in the paracancerous tissue group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the expression of NF-κB p65 protein in skin squamous cell carcinoma under different genders and ages(P>0.05).The positive rate of NF-κB p65 protein expression in patients with stage Ⅲ-Ⅳwas higher than that of patients with stage Ⅰ-Ⅱ,and the difference was statistically significant(P<0.05).The positive rate of NFκB p65 protein expression in poorly differentiated patients was higher than that in highly differentiated patients,and the difference was statistically significant(P<0.05).Conclusion The expression of NF-κB p65 protein in skin squamous cell carcinoma is higher than that in paracancerous tissue,and the higher the stage of skin squamous cell carcinoma is,the higher the expression of NF-κB p65 protein is,and the lower the degree of differentiation of skin squamous cell carcinoma is,the higher the expression of NF-κB p65 protein is.However,there is no significant relationship between the expression of NF-κB p65 protein and the age and gender of the patients.

 

 

[Abstract]Objective To analyze the effect preoperative combined use of Western medicine Cisplatin and traditional Chinese medicine Emodin on WIG-1 mRNA of human esophageal squamous cell carcinoma.Methods A total of 120 patients with esophageal squamous cell carcinoma in Xiangya Ping Mining Cooperation Hospital from January 2019 to August 2020 were selected as the research objects.All patients were treated with Western medicine Cisplatin and traditional Chinese medicine Emodin for three courses.According to the different tissue locations of the lesions taken during the operation,they were divided into observation group and control group.In the observation group,the tumor tissue was taken during the operation,and in the control group the paracancerous tissue at the distance of more than 3 cm from the tumor site was taken during the operation,60 cases in each group.After collecting samples of different lesions,the WIG-1 mRNA expression level was analyzed by real-time fluorescent quantitative polymerase chain reaction(RTPCR)technology.Results The WIG-1 mRNA expression level in tumor tissue of the observation group was(0.79±0.14),which was higher than that(0.06±0.02)of the control group,and the difference was statistically significant(P<0.05).The WIG-1 mRNA expression level in the tumor tissue of the observation group after operation was(0.24±0.04),which was lower than(0.79±0.14)before operation,and the difference was statistically significant(P<0.05).Conclusion The expression of WIG-1 mRNA is less in non-diseased tissue,and the combination of Western medicine Cisplatin and traditional Chinese medicine Emodin before operation is beneficial to reduce the expression of WIG-1 mRNA in patients with esophageal squamous cell carcinoma,which can better improve the prognosis of patients,and provide clinical and molecular basis for the treatment of esophageal squamous cell carcinoma.

Objective To investigate the clinical effect of Polyene Phosphatidylcholine combined with Ademetionine for intrahepatic cholestasis of pregnancy(ICP).Methods A total of 93 ICP patients admitted to Ningxi Branch,Zhuhai Maternal and Child Health Hospital from July 2018 to July 2020 were selected as the research subjects.They were divided into the control group(n=46)and the observation group(n=47)according to the random envelope method.The control group was treated with Ursodeoxycholic Acid Tablets,and the observation group was provided with Polyene Phosphatidylcholine combined with Adenosine.The levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bile acid(TBA)and total bilirubin(TBil)before and after treatment were compared between the two groups,as well as the pregnancy outcomes and neonatal situations.Results After treatment,the levels of AST,ALT,TBA and TBil in 2 groups were lower than before treatment,and the levels of AST,ALT,TBA and TBil in the observation group were lower than those in the control group,with statistical significances(P<0.05).The incidence of fetal distress,amniotic fluid and feces contamination,premature delivery and neonatal asphyxia in the observation group was lower than that in the control group,and Apgar score of neonates in the observation group was higher than that in the control group,with statistical significances(P<0.05).Conclusion Polyene phosphatidylcholine combined with Ademetionine can effectively reduce AST,ALT,TBA,and TBil levels and improve pregnancy outcomes in ICP treatment.

Objective To analyze and compare the clinical features,pathogens and prognosis of bacterial and fungal late-onset sepsis(LOS)in very low/extremely low birth weight infants.Methods The clinical data of 62 infants with very low/extremely low birth weight sepsis who were admitted to the First Affiliated Hospital of Anhui Medical University from July 2015 to June 2020 were collected and retrospectively analyzed.According to the results of blood culture,they were divided into a bacterial group(n=37)and a fungal group(n=25).The incidence,mortality,and pathogenic bacteria of LOS of the two groups were counted,and the clinical manifestations and prognosis of the two groups were analyzed and compared.Results There were 1115 very low/extremely low birth weight infants during the study period,and the incidence of positive blood culture sepsis was 5.56%.The most common pathogen in the bacterial group was Klebsiella pneumonia(12 strains,19.35%),and the most common pathogen in the fungal group was Candida glabrata(11 strains,17.74%).In the fungal group,the incidence of apnea,abdominal distension/vomiting/retention,and splenauxe was higher than that in the bacterial group,and the difference was statistically significant(P<0.05).The incidence of increased heart rate in the bacterial group was higher than that of the fungal group,and the ratio of platelets <100×109/L was lower than that in the fungal group,and the differences were statistically significant(P<0.05).The values of C-reactive protein(CRP)and procalcitonin(PCT)were higher than those in the fungal group,and the differences were statistically significant(P<0.05).The complication of central nervous system infection in the bacterial group was lower than that in the fungal group,and the difference was statistically significant(P<0.05).Conclusion The incidence of LOS in very low/extremely low birth weight infants is high.The clinical manifestations at onset are not specific.Increased heart rate,elevated CRP and PCT indicate bacterial infection.Apnea,abdominal distension,vomiting,retention,splenauxe,and decreased platelet are more indicative of fungal infection.Children with fungal infection are more likely to develop central nervous system infection than those with bacterial infection.

Objective To explore the clinical effect of carbon dioxide laser under suspension laryngoscopy in the treatment of early glottic carcinoma.Methods Thirty patients with early glottic laryngeal cancer admitted to the Jiujiang First People′s Hospital from January 2019 to June 2020 were selected as the research subjects and divided into control group(n=15)and treatment group(n=15)according to random number table method.The control group were treated with local laryngectomy for dehiscence,and the treatment group were treated with carbon dioxide laser under suspension laryngoscope.The treatment effect,quality of life,voice function,survival rate and recurrence rate were compared between the two groups.Results The total effective rate and survival rate in the treatment group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in preoperative quality of life scores between the two groups(P>0.05).Three months after operation,the quality of life score of the treatment group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in voice function between the two groups before operation(P>0.05).Three months after surgery,the longest vocalization time in the observation group was longer than that in the control group,the sound pressure level was higher than that in the control group,and the fundamental frequency perturbation was lower than that in the control group,the differences were statistically significant(P<0.05).Three months after operation,the recurrence rate of the treatment group was 6.67%(1/15),lower than that of the control group(46.67%,7/15),and the difference was statistically significant(P<0.05).Conclusion The diagnosis and treatment of early glottic cancer using carbon dioxide laser under suspension laryngoscope is ideal.It can accurately remove the tumor,with high repeatability and safety,which minimizes the impact of the body pain caused by the nasogastric tube.It can achieve the effect of true minimally invasive treatment.

Objective To explore and analyze the application effect of bracketless invisible appliance in orthodontic treatment.Methods A total of 50 orthodontic patients admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from June 2018 to June 2019 were selected as the research subjects.They were divided into observation group and control group by computer random drawing method,with 25 cases in each group.Patients in the observation group were treated with bracketless invisible appliance,and patients in the control group were treated with MBT metal bracket straight wire appliance.The periodontal index(gingival index[GI],plaque index[PLI],gingival crevicular bleeding index[SBI],gingival crevicular depth[SPD])of the two groups were compared.The satisfaction scores of dental aesthetics,social interaction,comfort,oral hygiene,psychological disorders,correction process,quality of life and the number of visits were compared between the two groups.The adverse reaction scores of oral ulcer,tooth pain and masticatory difficulty were compared between the two groups.Results After 6 months of treatment,GI,PLI and SBI in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in SPD between the two groups after 6 months of treatment(P>0.05).After 12 months of treatment,the satisfaction scores of patients in dental aesthetics,social interaction,comfort,oral hygiene,psychological disorders,correction process,quality of life and the number of visits in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The adverse reaction score of oral ulcer,tooth pain and masticatory difficulty in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).Conclusion In the clinical orthodontic treatment,the bracketless invisible appliance has a definite effect and significant clinical application value.

Objective To compare the effect of vitreous injection of Ranibizumab and Conbercept in the treatment of macular edema.Methods A total of 128 patients with macular edema admitted to the ophthalmology department of Heyuan People′s Hospital from December 2018 to December 2019 were selected as the research subjects,and randomly divided into the observation group(64 cases)and the control group(64 cases)by drawing lots.The observation group was treated with vitreous injection of Ranibizumab,while the control group was treated with vitreous injection of Conbercept.The macular fovea retinal thickness,the total incidence of complications,the total effective rate of treatment and the visual acuity of two groups were compared.Results There was no significant difference in the thickness of macular fovea between the two groups(P>0.05).There was no statistical significance in the total incidence of complications between the two groups(P>0.05).There was no significant difference in the total effective rate between the two groups(P>0.05).There was no significant difference in visual acuity between the two groups at different time points(P>0.05).Conclusion The vitreous injection of Ranibizumab in the treatment of macular edema has the same effect as the treatment of Conbercept,with better curative effect and fewer complications,which can be selected according to the actual condition of the patient.

Objective To analyze the effect of ultrasound-guided erector spinae plane block in thoracoscopic lobectomy in elderly patients.Methods From January 2018 to February 2020,72 elderly patients who underwent thoracoscopic lobectomy in the Department of Anesthesiology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were selected as research objects,and they were divided into control group and observation group by random number table method,with 36 cases in each group.The control group was given total intravenous anesthesia,while the observation group was given ultrasound-guided erector spinae plane block on the basis of the control group.The lung function,ventilation disturbance before anesthesia induction(T0),after tracheal tube removal(T1)and after thoracic drainage tube removal(T2)and postoperative analgesia were compared between the two groups.Results There were no significant differences in the peak expiratory flow rate(PEFR),the forced expiratory volume in 1 second(FEV1),the forced vital capacity(FVC)and FEV1/FVC between the two groups at T0(P>0.05).The PEFR,FEV1,FVC at T1 and T2 in the two groups were lower than T0,and the differences were statistically significant(P<0.05).The PEFR in the observation group was higher than that at T1,and higher than that in the control group,the differences were statistically significant(P<0.05).The FEV1 in the observation group was higher than that in the control group at T1,and the difference was statistically significant(P<0.05).The FEV1 in the control group at T2 was higher than that at T1,and the difference was statistically significant(P<0.05).The FVC in the observation group was higher than that in the control group at T2,and the difference was statistically significant(P<0.05).At T1,the proportion of patients with restrictive,obstructive and mixed ventilation disorders in the observation group were lower than that in the control group,and the differences were statistically significant(P<0.05).There were no significant differences between the two groups in the occurrence of different types of ventilation disorders at T0 and T2(P>0.05).During the postoperative hospitalization,the actual times of pressure and remedial analgesia in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the effective pressing times of analgesic pump between the two groups(P>0.05).Conclusion Anesthesia of elderly patients undergoing thoracoscopic lobectomy combined with ultrasound-guided erector spinae plane block on the basis of total intravenous anesthesia could effectively improve the pulmonary function of patients and reduce the occurrence of ventilation disorder,and has better analgesic effect without increasing the occurrence of complications.

Objective To study the effect of different ventilation modes on respiratory mechanical parameters and postoperative recovery quality of infants undergoing laparoscopic surgery.Methods From September 2019 to October 2020,50 children with laparoscopic surgery in People′s Hospital of Pingxiang City were selected as the research objects and divided into pressure controlled ventilation(PCV)group and volume controlled ventilation(VCV)group accoeding to random assignment method,with 25 cases in each group.PCV group was given PCV mode,and VCV group was given VCV mode.The intraoperative medication of the two groups was consistent.The airway peak pressure(Ppeak),airway mean pressure(Pmean),airway flat pressure(Pplat),end-expiratory pressure of carbon dioxide(PETCO2)and postoperative agitation score were compared between the two groups after tracheal intubation(T0),1 min after pneumoperitoneum(T1),10 min after pneumoperitoneum(T2),and before descopization(T3).Results There were no statistically significant differences in Ppeak,Pmean,Pplat and PETCO2 levels between the two groups at T0(P>0.05).Ppeak,Pplat and PETCO2 in PCV group at T1,T2 and T3 were lower than those in VCV group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in Pmean between the two groups at T1,T2 and T3(P>0.05).The score of postoperative agitation in PCV group was lower than that in the VCV group,and the difference was statistically significant(P<0.05).Conclusion General anesthesia with PCV ventilation mode in pediatric laparoscopic surgery has high safety and stability,stable vital signs of children,and can improve the quality of recovery,and ensure the safety of children in the operation to the maximum extent.

Objective Based on literature retrieval and data mining,to analyze the treatment rules of traditional Chinese medicine(TCM)for acute gastrointestinal function injury(AGI),so as to provide clinical reference for drug use.Methods The medical research literature of AGI treatment by TCM in January 1,2010 to December 31,2020 were collected from CNKI、Wanfang and VIP database.According to the inclusion and exclusion criteria，all the literature were screened and the information of prescriptions and medicines were extracted to establish the database.Imported the database into the ancient and modern medical record cloud platform(V2.2.3)and analyzed the frequency,attribute,correlation and complex network of medication.Results A total of 58 prescriptions were included,involving 56 kinds of Chinese medicine.The top five Chinese medicine with the higher frequency of prescriptions were Rhubarb,Magnolia officinalis,Fructus aurantii Immaturus,Mirabilite,Fried Licorice and the average using dose were 12.48 g,13.72 g,12.07 g,11.59 g and 7.42 g.The main property of medicine was warm,cold,flat,and tastes were bitter,pungent and sweet.The main belonged meridians were spleen,stomach and lung.The results of correlation and complex network analysis showed that the core prescription was Dachengqi Decoction combined with Angelica,Codonopsis,Aconite,Fried Atractylodes macrocephala,Fried Licorice.Conclusion The clinical treatment of acute gastrointestinal injury with

TCM could based on Dachengqi Decoction.At the same time，it can be combined with medicines such as warming Yang、invigorating Qi or invigorating the Spleen to obtain better therapeutic effects.

Objective To analyze the constitution characteristics of traditional Chinese medicine(TCM)in patients with H-type hypertension.Methods A total of 280 patients with essential hypertension who were admitted to Fangshan Hospital Beijing University of Chinese Medicine from January 2018 to December 2019 were selected as the research subjects,and were divided into observation group(210 cases)and control group(70 cases)according to whether they were complicated with hyperhomocysteinemia(HHCY).The observation group was H-type hypertension patients,and the control group was non H-type hypertension patients.TCM constitution identification was performed on the two groups of patients,and the TCM constitution characteristics of the patients were counted and analyzed.Results The proportion of male in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The biased constitution of 210 patients with H-type hypertension was mainly composed of phlegm-dampness(18.21%),qi deficiency(15.90%),yang deficiency(15.13%)and damp-heat(14.87%).The biased constitution of 70 patients with non-H-type hypertension were mainly Qi deficiency(21.99%),Yang deficiency(19.86%),Qi stagnation(12.77%)and phlegm dampness(12.06%).The proportion of men with phlegm-dampness and damp-heat quality in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion H-type hypertension is related to all types of constitution in traditional Chinese medicine.Among them,it is closely related to phlegm and dampness,and the prevalence of men is higher.This is of great significance for guiding Chinese medicine to treat hypertension by adjusting the constitution,use drugs for different constitution,and improve clinical efficacy.

Objective To compare the rapid diagnosis value between sputum fungal smear and sputum fungal immunofluorescence staining in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Sputum specimens from 60 patients with AECOPD diagnosed in Ji′an Hospital,Shanghai Dongfang Hospital from June 2019 to June 2020 were selected as the research objects.The sputum specimens were timely sent for examination of general fungal smear,immunofluorescence staining of sputum,culture of sputum fungi and others,and statistical data were collected.According to the gold standard of sputum fungal culture,the positive rate of fungal culture was compared between the methods of sputum fungal smear and immunofluorescence,as well as the sensitivity,specificity and accuracy.Results The sensitivity of the immunofluorescence assay of sputum fungus was 92.86%,which was higher than 71.42% of the sputum fungal smear,with statistically significant difference(P<0.05).The specificity of the sputum fungal immunofluorescence assay was 88.89%,which was higher than 66.67% of sputum fungal smear,with statistically significant difference(P<0.05).The accuracy of the immunofluorescence of sputum fungus was 93.33%,which was higher than 70.00% of the sputum fungal smear,with statistically significant difference(P<0.05).Conclusion Compared with the sputum fungal smear,the fungal immunofluorescence assay has higher sensitivity,specificity and accuracy in the rapid diagnosis of AECOPD,which can reduce the occurrence of false negative results and the rate of missing detection and is thus worthy to be applied widely.

Objective To explore and analyze the value of combined serum procalcitonin,C-reactive protein and blood routine in the clinical diagnosis of children with bacterial infections.Methods A total of 84 infected children admitted to Baicheng Hospital from March 2019 to June 2020 were selected as the research objects and divided into the study group(with bacterial infection)and the reference group(non-bacterial infections),with 42 cases in each group.All children received serum procalcitonin and C-reactive protein and routine blood tests.Statistical analysis of the study group and the reference group of serum procalcitonin and C The accuracy,sensitivity and specificity of the detection results of reactive protein and blood routine test and serum procalcitonin detection,C-reactive protein detection,blood routine detection and combined detection.Results The detection levels of serum procalcitonin,C-reactive protein and white blood cell counts in the study group were higher than those of the reference group,and the positive detection rates of serum procalcitonin,C-reactive protein and blood routine tests were all higher than those of the reference group.The accuracy,sensitivity,and specificity were higher than those of serum procalcitonin detection,C-reactive protein detection and blood routine detection,and the differences were statistically significant(P<0.05).Conclusion There are significant differences in the levels of serum procalcitonin,C-reactive protein and white blood cell counts between children with bacterial infections and children with non-bacterial infections.Serum procalcitonin,C-reactive protein and blood routine tests can accurately distinguish different infection groups ,The diagnostic value of the combined test is significantly higher than that of a single test,and it can be flexibly selected according to the actual situation in clinical practice.

Objective To understand the current medication adherence of the patients suffering from chronic diseases,analyze its relationship with medication convictions and provide a path to improve the medication adherence level of the patients suffering from chronic diseases.Methods A total of 220 patients suffering from hypertension,diabetes,coronary heart disease and other chronic diseases who were admitted to the Chronic Disease Clinic of a grade-A and first-class hospital in Wuhu from October 7 to 13,2019 were randomly selected.The medication adherence report scale(MARS-5)and beliefs about medical questionnaire(BMQ-G)were used to investigate the patients,and the data obtained from the survey were statistically analyzed.Results The patients suffering chronic diseases were poor in medication adherence,with the score of(14.25±3.15)points.Medication adherence was related to gender,age,and educational background(P<0.05),while it was not related to the type of diseases(P>0.05).There was a correlation between the three dimensions of medication convictions(excessive application,beneficial convictions and harmful convictions)and medication adherence(P<0.01).Beneficial convictions and excessive application could exert a significant prediction effect on medication adherence(P<0.01).Conclusion Patients suffering from chronic diseases have a low medication adherence level,and there are obvious differences in gender,age and education;among the medication convictions of the patients suffering from chronic diseases,beneficial conviction predicts medication adherence positively,and excessive application negatively predicts medication adherence.

Objective To investigate the infection of Helicobacter pylori(Hp)in the population tested in the Second People′s Hospital of Jingdezhen.Methods A total of 48 353 subjects who underwent 14C-urea breath test in the Second People′s Hospital of Jingdezhen from July 2008 to December 2019 were collected for statistical analysis.Results The infection rate of Hp in 48 353 subjects was 42.94%,of which 43.21% were males and 42.67% were females.There was no statistically significant difference between males and females in Hp infection rate(P>0.05).The highest infection rate of Hp was 47.43% in the age group of 30-<40 years old.The infection rate of Hp decreased year by year since 2015.There was significant difference in infection rate of Hp between people with gastrointestinal symptoms and those with physical examination(P<0.05).Conclusion The infection rate of Hp in the Second People′s Hospital of Jingdezhen is similar to that of the national level，and there is no difference between genders.The Hp infection rate is the highest in the age group of 30-<40 years old,and the infection rate is decreasing year by year.

Objective To discuss the preliminary construction of the intelligent triage function of the WeChat official account platform.Methods A total of 1000 patients who received manual triage in the Department of Outpatient,Jiangxi Provincial Dermatology Hospital from May 2019 to July 2019 were selected as the control group,1000 patients who received intelligent triage on the WeChat official account platform in the Department of Outpatient,Jiangxi Provincial Dermatology Hospital from August 2019 to October 2019 were selected as the observation group.Triage accuracy,triage time,registration and waiting time and patient satisfaction were compared between the two groups.Results The triage accuracy of the observation group(98.80%)was higher than that of the control group(94.80%),and the difference was statistically significant(P<0.05).The time required for triage([63.12±7.96]s),waiting time for registration([15.31±3.05]min)and waiting time for treatment([22.43±5.29]min)in the observation group were shorter than those in the control group([86.19±8.24]s,[24.08±3.19],[30.35±5.36]min),and the differences were statistically significant(P<0.05).The scores of triage method([17.83±2.01]points),triage skill([17.89±1.95]points),treatment environment([17.80±1.93]points),humanization service([17.75±1.99]points)in the observation group were higher than those of the control group([15.94±2.31],[15.96±2.33],[15.97±2.35],[15.88±2.43]points),and the differences were statistically significant(P<0.05).Conclusion The initial construction of the intelligent triage function of the WeChat official account platform can improve the accuracy of triage,greatly shorten the time of patient triage and consultation,and help improve the nurse-patient and doctor-patient relationship,thereby increasing patient satisfaction.

Objective To study the application value of multi-center homogeneous medical quality management in obstetrics and gynecology.Methods A total of 102 patients admitted to the Department of Obstetrics and Gynecology of Dalian Maternity and Child Health Hospital from August 2017 to December 2019 were selected as the research objects,and they were divided into two groups according to the random number table method,with 51 cases in each group.The control group underwent routine management,and the observation group underwent multi-center homogeneous medical quality management.The clinical satisfaction,management quality scores and medical staff service scores were compared between the two groups.Results After the intervention,the scores of health education,service attitude,complication management and ward management of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).The total clinical satisfaction rate of the observation group(96.08%)was higher than that of the control group(78.43%),the difference was statistically significant(P<0.05).After the intervention,scores of specialized theory,skills and humanistic ability in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The application of multi-center homogeneous medical quality management in obstetrics and gynecology can effectively improve management quality and service quality,thereby improving clinical satisfaction.

Establish the evaluation index system of regional medical equipment and identify the index weight of every layer in order to lay the foundation for further evaluation of the overall strength of hospital medical equipment.Focusing on the quality evaluation of medical equipment,this paper proposes a medical equipment quality evaluation model based on analytical hierarchy process,and calculates the weight of various influencing factors to get the main factors affecting the quality of medical equipment.The weight of medical equipment evaluation index system is applicable using the proposed method,which can provide powerful value for the regional medical equipment evaluation combined with the comprehensive model.

Objective To explore the practice and effect of implementing the chief resident work model of midwives to cultivate junior midwives.Methods From March 2017 to November 2019,the Obstetrics Department of Guangdong Maternal and Child Health Hospital successively carried out midwife chief resident training for 33 N1 midwives,with each cycle of 3 months,training 3 midwives in each period.A total of 11 sessions were carried out.Their participations in the department during the chief resident period as a midwife were analyzed.The core competence assessment and general self-efficacy scores of the 33 midwives before and after the training were compared.Results During the chief resident period as a midwife,the 33 midwives actively participated in the work of the department and exceeded the total requirements of the department.After the implementation of the midwife chief resident training model,the total score of midwives′ core competence assessment([80.98±1.55]points)was higher than that before the implementation([70.30±1.96]points),and the difference was statistically significant(P<0.001).Using the mini-clinical evaluation exercise(Mini-CEX)to evaluate the delivery of single birth by midwives,the excellent rate increased from 45.45%(15/33)to 90.91%(30/33),the proportion of midwives who scored excellence in the assessment of singleton deliveries after the implementation was higher than that before the implementation,and the difference was statistically significant(P<0.001).The general self-efficacy score after the implementation([3.07±0.11]points)was higher than that before the implementation([2.05±0.15]points),and the difference was statistically significant(t=34.690, P<0.001).Conclusion The implementation of chief resident work model is conductive to improve the midwifery quality for junior midwives,can effectively improve their core competency,and significantly enhance their self-efficacy.

General internal medicine is an important part of clinical medicine,because the general internal disease involves a wide range and the disease manifestation is complex,which needs the clinician to focus on the research.Clinical teaching of general internal medicine is not only to impart relevant theoretical knowledge to medical students,but also more importantly to teach clinical learning physicians the ability to solve problems in practice.Although traditional lecture based learning(LBL)teaching method can better teach students theoretical knowledge,it is not as good as case-based learning(CBL)teaching method in cultivating students′ practical ability.CBL teaching mode can stimulate students′ interest in learning,improve their clinical critical thinking ability,closely connect theory with practice,and better cultivate students′ clinical diagnosis and treatment ability.

Objective To discuss the application of case teaching method in the teaching of antiviral nursing interns with chronic hepatitis B.Methods A total of 60 nursing interns from January to December in 2019 were selected for the study,and they were divided into group A and group B by random number table method,with 30 cases in each group.Group A was taught by routine interns.On this basis,group B was given case teaching method.Theoretical knowledge,case analysis results,comprehensive ability and satisfaction with teaching effect were compared between the two groups of interns.Results The scores of theoretical knowledge,case analysis and the total score of group B were higher than those of group A,and the differences were statistically significant(P＜0.05).The total scores of operation skills,emergency ability,observation ability and comprehensive ability of group B were higher than those of group A,and the differences were statistically significant(P＜0.05).The scores of students in group B in teaching content,teaching methods,interest,ability improvement,deepening theoretical knowledge understanding and improving comprehensive analysis ability were higher than those in group A,and the differences were statistically significant(P＜0.05).Conclusion Case teaching method has a good effect in the teaching of chronic hepatitis B antiviral nursing interns,which can improve the interns′ knowledge of the disease,related nursing skills and self-protection ability,it is worthy of promotion.

Objective To explore the application effect of peer education in experience tools of diabetic complications.Methods A total of 60 newly diagnosed type 2 diabetic patients in Ganzhou People′s Hospital from May 2018 to May 2019 were selected as the research subjects.They were divided into the control group(n=30)and the observation group(n=30)by lottery method.In the control group,routine diabetes health education was used.In the observation group,diabetes health education with strengthened peer education was adopted.Patients′ blood glucose indicators before and after intervention,self-management behavior ability score and nursing service satisfaction after intervention between the two groups were compared.Results The levels of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin of the two groups after intervention were lower than those before intervention,with statistical significances(P<0.05).The levels of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in the observation group after intervention were lower than those in the control group,with statistical significances(P<0.05).The self-management behavior score and nursing service satisfaction of the observation group were higher than those of the control group,with statistical significances(P<0.05).Conclusion Emphasis on the application of peer education in diabetic complication experience tool in diabetes management can improve the blood glucose control effect and self-management ability of diabetic patients,continuously improve the quality of service,and lay the foundation for the prevention of diabetic complication.

The problems and limitations in the teaching of Traditional Chinese medicine research laboratory,such as the lack of Traditional Chinese medicine research hours,difficulty to understanding Traditional Chinese medicine research,little practical application and value recognition,limited teaching mode,were analyzed.We have tried to establish the teaching and practice system for Traditional Chinese medicine scientific research by improving the teaching mode and means.Small class system was established;the application teaching of Traditional Chinese medicine research instruments was strengthened;the practical teaching of molecular biology and pathological examination technology was solidified;open examination paper was used to improve the examination system,and the bottleneck of Traditional Chinese medicine scientific research laboratory teaching was broken through.The above methods not only introduced the advanced Traditional Chinese medicine research knowledge,but also expanded students′ visual field,stimulated students′ interest in learning and enhanced their passion for Traditional Chinese medicine research.As a result,The construction of teaching and practice system in Traditional Chinese medicine scientific research laboratory could help improve the teaching status in the lab,and guide students to learn and grasp the thought methods of TCM scientific research.

The cultivation of innovative stomatology talents is an urgent need for stomatology education under the background of the new era.Dedication of moral education is necessary for stomatology education and ideological and political education should be transformed into the whole process of professional education.Clearly stipulate the training objectives of "emotions,attitudes and values" in the training plan,and gradually implant the "curriculum ideological and political" system of dental medicine education to realize the organic integration of ideological and political education and professional courses.Moral education should be deeply rooted in the curriculum construction to strengthen the humanities education and professional quality training of dental medicine students.Dig deep into the ideological and political elements of professional courses to stimulate students′ sense of innovation and scientific research and exploration spirit.In the process of scientific research,strengthen the scientific literacy and humanistic spirit of dental medicine students,and enhance the cognition of lifelong learning and scientific research practice ability of dental medicine students continue.Enhance the scientific research and innovation ability of dental medicine students through the exploration and practice of curriculum ideological and political,and cultivate innovative dental medicine talents that meet the needs of society.

Objective To investigate the effect of patient-centered learning mode on health education of patients after percutaneous coronary intervention(PCI).Methods A total of 115 patients after PCI in Huizhou Central People′s Hospital from January to December 2019 were divided into an observation group(58 cases)and a control group(57 cases)by a random number table method.Patients in the observation group were treated with patient-centered learning mode to implement health education,and in the control group,patients were treated with routine health education.The scores of disease rehabilitation knowledge,secondary prevention abilities,blood pressures and blood lipids were collected and compared between the two groups before discharge,3 and 6 months after discharge.Results The scores of disease rehabilitation knowledge,secondary prevention ability and high density lipoprotein levels in observation group were higher than those in control group at 3 and 6 months after discharge,and the levels of cholesterol,triglyceride and low density lipoprotein in observation group were lower than those in control group,the differences were statistically significant(P<0.05).The scores of disease rehabilitation knowledge,secondary prevention ability and high density lipoprotein levels of two groups at 3 and 6 months after discharge were higher than those before discharge,and the levels of cholesterol,triglyceride and low density lipoprotein of two groups were lower than those before discharge,the differences were statistically significant(P<0.05).Blood pressures before discharge,3 and 6 months after discharge between two groups were compared,the difference was not statistically significant(P>0.05).Conclusion By implementing health education in patient-centered learning mode,it is possible to improve the health behavior and disease status of patients after PCI to a certain extent.

Objective To explore the influence of systematic health education and postpartum breast massage on breast feeding.Methods A total of 120 cases of full-term natural delivery and single birth primiparas accompanied by their husbands in Dalian Women and Children′s Medical Center from February to May in 2020 were selected as the research objects,and they were divided into the control group and the observation group according to random number table method,with 60 cases in each group.The observation group was given systematic health education,the maternal and husband were given systematic health education on breast feeding related knowledge and skills,and breast massage was given after delivery.The control group was only given routine breast-feeding guidance.The scores of breastfeeding related knowledge,skills,breast milk volume and breast swelling of the two groups were compared.Results The score of breastfeeding related knowledge in the observation group after intervention was higher than that in the control group,and the difference was statistically significant(P＜0.05).The breastfeeding skills of the observation group was better than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the amount of breast milk at 3 days after delivery between the two groups(P＞0.05).The ratio of breast milk adequate in the observation group at 30 days after delivery was more than that in the control group,and the difference was statistically significant(P＜0.05).The breast swelling rate of primipara in the observation group was 5.00%(2/60),which was lower than 16.67%(10/60)of the control group,the difference was statistically significant(P＜0.05).Conclusion Providing systematic health education and early breast massage for pregnant women and their families,promoting husband′s participation and support can improve maternal confidence in breastfeeding,promote maternal milk secretion and reduce breast swelling.

Objective To explore the application effect of Chuankezhi Zusanli acupoint injection in airway nursing after tracheotomy.Methods A total of 60 patients with tracheotomy treated in Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from July 2018 to July 2019 were selected as subjects and divided into the observation group(n=30)and the control group(n=30)according to random number table method.The control group was given routine airway nursing,and the observation group was given Chuankezhi Zusanli acupoint injection on the basis of the control group.The improvement of clinical symptoms,changes of blood gas indexes and adverse reactions were compared between the two groups.Results After nursing,the scores of cough,wheezing and expectoration in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The arterial oxygen partial pressure(PaO2)in the observation group was higher than that in the control group,the arterial partial pressure of carbon dioxide(PaCO2)in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).There was no adverse reaction in the control group,and 1 patient in the observation group had mild skin pruritus,the difference was not statistically significant(P＞0.05).Conclusion Chuankezhi Zusanli acupoint injection has a good effect in airway nursing after tracheotomy,which can relieve clinical symptoms,improve blood gas,and has less adverse reactions.

Objective To explore the effect of systematic rehabilitation training at different timings on motor function and neurological dysfunction in elderly patients with cerebral infarction.Methods From January to December 2020,98 elderly patients with cerebral infarction admitted to Jiujiang First People′s Hospital were selected as the research objects.Using random number table method,they were divided into Halle group(49 cases)and Olivier group(49 cases).Patients in the Halle group received early rehabilitation training,and patients in the Olivier group received late rehabilitation training.The improvement of motor function and neurological dysfunction after nursing was compared between the two groups.Results The upper and lower limb movement scores in Halle group was higher than that in the Olivier group,and scores of comparative neurological function were lower than those in Olivier group,nursing effect of the Halle group was better than that of the Olivier group,the differences were statistically significant(P<0.05).Conclusion The use of early rehabilitation training can better improve the patient′s limb movement level,improve the patient′s neurological dysfunction,and help the patient to restore health.It is worthy of promotion in the course of disease care.

Objective To explore the effect of narrative psychotherapy on the choice of delivery mode and postpartum breastfeeding of high-risk pregnant women.Methods From May to December 2020,80 high-risk pregnant women admitted to the Second Affiliated Hospital of Gannan Medical University were selected as the research objects.According to coin tossing method,they were divided into the control group and the observation group,40 patients in each group.Patients in the control group were given routine nursing,while patients in the observation group were given routine nursing and narrative psychological intervention.Both groups were observed for 8 weeks.The psychological status,delivery modes and outcomes,and scores of breastfeeding self-efficacy scale of the two groups were compared.Results Before intervention,there were no significant differences in the scores of anxiety and depression between the two groups(P＞0.05).After narrative psychotherapy,anxiety and depression of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The natural labour rate in the observation group was higher than that in the control group,and delivery outcome was better than that in the control group,the differences were statistically significant(P<0.05).Before intervention,there were no significant differences in breastfeeding knowledge and confidence in breastfeeding scores between the two groups(P＞0.05).After intervention,breastfeeding knowledge and confidence in breastfeeding scores of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion Narrative psychotherapy can alleviate unhealthy emotions of parturients,reduce the incidence of fetal distress,lower the risk of childbirth,and improve maternal confidence in breastfeeding.

Objective To explore the application of targeted nursing intervention in the treatment of infertility patients with polycystic ovary syndrome(PCOS)and insulin resistance by in vitro fertilization and embryo transfer(IVF-ET).Methods A total of 84 cases of PCOS infertility with insulin resistance treated by IVF-ET in Dalian Maternal and Child Health Hospital from February 2019 to February 2020 were selected as the research objects,and they were divided into the study group and the reference group according to random number table method,42 cases in each group.The control group was given routine nursing intervention during IVF-ET treatment,while the study group was given targeted nursing intervention during this period.Self rating anxiety scale(SAS)and self rating depression scale(SDS)were used to evaluate the psychological changes of patients before and after the intervention.The fertilization success rate,embryo implantation rate and pregnancy rate of the two groups were compared statistically.The nursing satisfaction of the two groups was analyzed by questionnaire.Results Before the intervention,there were no significant differences in the psychological state scores between the two groups(P＞0.05).After the intervention,the SAS and SDS scores of the two groups were lower than those before the intervention,the SAS and SDS scores of the study group were lower than those of the reference group,the differences were statistically significant(P<0.05).The embryo implantation rate and pregnancy rate of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the success rate of fertilization between the two groups(P＞0.05).The nursing total satisfaction of the study group was higher than that of the reference group,and the difference was statistically significant(P＞0.05).Conclusion The application of targeted nursing intervention in PCOS patients with insulin resistance infertility during IVF-ET treatment can improve the emotional state of patients,help to improve the embryo implantation rate and pregnancy rate,improve the pregnancy outcome and enhance nursing satisfaction.

Objective To study the clinical effect of mindfulness cognitive therapy combined with comprehensive nursing intervention in patients with depression during treatment.Methods A total of 72 patients with depression admitted to Ganzhou Third People′s Hospital from August 2018 to November 2020 were selected as the study subjects.They were divided into the control group and the observation group by randomization method,36 cases in each group.The control group was only treated with mindfulness cognitive therapy,the observation group received mindfulness cognitive therapy combined with comprehensive nursing intervention.Psychological state,quality of life,quality of sleep,satisfaction with intervention mode,occurrence of adverse events,time to return to normal mental state and total length of hospital stay were compared between two groups before and after nursing.Results The scores of mental state and sleep quality in the observation group were lower than those in the control group,and the scores of life quality in the observation group were higher than those in the control group,with statistical differences(P<0.05).The nursing total satisfaction of the observation group was higher than that of the control group,the total incidence of adverse events in observation group was lower than that of the control group,the differences were statistically significant(P<0.05).The psychological state normalization time and hospitalization time of observation group were shorter than those of the control group,the differences were statistically significant(P<0.05).Conclusion Mindfulness cognitive therapy combined with comprehensive nursing intervention can improve the psychological state,sleep quality and quality of life of patients with depression,reduce adverse events,quickly restore the psychological state,shorten the length of hospital stay,and improve the satisfaction.

Objective To explore the effect of biofeedback combined with electrical stimulation in the treatment of postpartum pelvic floor dysfunction(PFD).Methods A total of 60 patients with PDF treated in Dexing Maternal and Child Health Hospital,Jiangxi Province from June 2019 to April 2020 were selected as the research objects.By the random number table method,they were divided into the control group and the observation group,30 cases in each group.The control group was received vaginal dumbbell training,and the observation group was received biofeedback combined with electrical stimulation.Both groups were treated for 3 months,the pelvic floor function(pelvic floor distress inventory-short form 20[PFDI-20],urinary incontinence[international consultation on incontinence questionnaire urinary incontinence short form[ICI-Q-SF],pelvic floor muscle strength and uterine prolapse were observed between the two groups.Results After treatment,the PFDI-20 and ICI-Q-SF scores of the two groups were lower than thosee before treatment,and the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the superficial and deep muscle fiber Ⅰand Ⅱscores of the two groups were higher than those before treatment,and the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).The uterine prolapse of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Biofeedback combined with electrical stimulation can effectively improve postpartum PFD,strengthen pelvic floor muscles,and improve uterine prolapse and urinary incontinence.

Objective To approach value of old age severe erythrodermic psoriasis complicated with diabetes by comprehensive nursing model.Methods A total of 80 cases old age severe erythrodermic psoriasis complicated with diabetes patients treated in Dalian Dermatology Hospital from June 2018 to June 2020 were selected as research objects,which were divided into the control group and the detection group by random slip method,40 cases in each group.The control group was used routine nursing mode,the detection group was used comprehensive nursing model,the anxiety score,depression score,delf-nursing ability score of two group before nursing and after nursing were compared,the nursing satisfaction and nursing error rate of two group were compared.Results The anxiety score,depression score,disease knowledge,self-monitoring,daily living ability,dietary self-regulation score of two group before nursing were compared,the differences were no statistical significance(P＞0.05).After nursing,anxiety score,depression score of two group were lower than before nursing in the same group,the detection group were lower than those of the control group,the differences were statistical significance(P<0.05).After nursing,disease knowledge,elf-monitoring,daily living ability,dietary self-regulation score of two group were higher than before nursing in the same group,the detection group were higher than those of the control group,the differences were statistical significance(P<0.05).The nursing satisfaction of the detection group was higher than that of the control group,nursing error rate was lower than that of the control group,the differences were statistical significance(P<0.05).Conclusion The application of old age severe erythrodermic psoriasis complicated with diabetes by comprehensive nursing model,which could improve anxiety and depression,increase delf-nursing level and nursing satisfaction,decrease nursing error rate.