重度阻塞性睡眠呼吸暂停低通气综合征患者呼出气一氧化氮水平及其与涎液化糖链抗原的相关性

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Abstract

Objective To investigate fractional exhaled nitric oxid(FeNO)of patients with severe obstructive sleep apnea and hypopnea syndrome(OSAHS)and its correlation with Krebs Von den Lungen-6(KL-6).Methods From January 2017 to December 2018,a total of 70 patients with severe OSAHS admitted to the Second People′s Hospital of Guangdong Province were selected as the experimental group,and seventy healthy persons in the same period were selected as the control group.The body mass index(BMI),apnea-hypopnea index(AHI),lowest oxygen saturation(LSaO2),KL-6 and FeNO levels of the two groups were compared,and the FeNO correlation with BMI,AHI,LSaO2,KL-6 were analysed.Results The level of BMI and AHI in the experimental group was higher than those in the control group,and the level of LSaO2 was lower than that in the control group,the differences were statistically significant(P<0.05).The levels of KL-6 and FeNO in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).FeNO level was positively correlated with BMI,AHI and KL-6(r=0.43,0.57,0.37, P<0.05).There was a negative correlation between FeNO and LSaO2(r=-0.49, P<0.05).Conclusion The levels of KL-6 and FeNO in patients with severe OSAHS increased,and the levels of FeNO were positively correlated with AHI and KL-6,and negatively correlated with LSaO2.It is suggested that FeNO is related to the severity of the disease and can be used as an index to evaluate the disease.

Key words： Obstructive sleep apnea and hypopnea syndrome Krebs Von den Lungen-6 Fractional exhaled nitric oxid Airway inflammation Oxidative stress induced lung injury

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