持续气道正压对单肺通气患者氧合及肺内分流影响的meta分析

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Abstract

Objective To explore the effect of continuous positive airway pressure(CPAP)on oxygenation and intrapulmonary shunt in patients with one-lung ventilation by meta-analysis.Methods PubMed,Embase,VIP,CNKI,Wanfang Data and other databases were searched by computer.The search time was from the inception to 31 December 2020.Randomized controlled trials(RCTs)on the effect of CPAP administered on the non-ventilated side during one-lung ventilation on patients′ oxygenation status and intrapulmonary shunt were collected.Two independent researchers screened and extracted relevant literature,and evaluated the quality of literature following the inclusion and exclusion criteria.Finally,RevMan 5.3 software was used to conduct a meta-analysis on the included RCTs.Results A total of 11 RCTs and 346 patients were included.Intrapulmonary shunt volume in CPAP group(one-lung ventilation 30 min:SMD=-1.08,95%CI=-1.37 to -0.79, P<0.000 01;one-lung ventilation for 60 min: SMD=-0.47,95%CI=-0.83 to -0.12, P=0.009)was lower than that of the control group,and arterial partial oxygen pressure(one-lung ventilation for 30 min: SMD=0.97,95%CI=0.73-1.20, P<0.000 01;one-lung ventilation for 60 min: SMD=0.72,95%CI=0.30-1.13,P=0.0007),and the differences were statistically significant(P<0.05).There was no significant difference in the partial pressure of carbon dioxide between the two groups(one-lung ventilation for 30 min: SMD=0.02,95%CI=-0.24 to -0.29, P=0.87;one-lung ventilation for 60 min: SMD=-0.18,95%CI=-0.70-0.35, P=0.51).Conclusion CPAP can significantly improve the oxygenation status and intrapulmonary shunt in patients with one-lung ventilation.

Key words： Continuous positive airway pressure One-lung ventilation Oxygenation Intrapulmonary shunt Metaanalysis

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	LIU Shu-jie
	GAO Jie
	WANG Yu
	YANG Shi-jie
	YAN Yu-rong

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LIU Shu-jie,GAO Jie,WANG Yu, et al. A meta-analysis of the effect of continuous positive airway pressure on oxygenation and intrapulmonary shunt in patients with one-lung ventilation[J]. 中国当代医药, 2021, 28(24): 16-20.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I24/16

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