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Quick Search     Adv Search 2018 Vol. 25, No. 9 Published: 2018-03-28   4 The effect of Propofol on the activation of p38 MAPK/NF-κB signal pathway in human umbilical vein endothelial cells induced by lipopolysaccharide WANG Xin;LEI Xiao-wen;CHEN Dan;LIU Bin bjective To study the influence of Propofol on the activity of p38,MAPK/NF-κ B signal pathway in human umbilical vein endothelial cells(HUBECs)induced by lipopolysaccharide (LPS).Methods HUBECs cultured in vitro were randomly divided into the 4 groups:control group(group C)was given Intralipid 20 mg/L,LPS group(L group)was given LPS 10 mg/L,Propofol group (P group)was given Propofol 20 mg/L,Propofol+LPS group (PL group)was given Propofol 20 mg/L and LPS 10 mg/L.The change in the content of p38 MAPK,p-p38 MAPK and NF-κB were detected at five time points of 1,2,3,6,and 12 h.Results When administered 1 h,the gray value of p-p38 MAPK and NF-κB in group L was 10.32±0.73,60.32±5.73 respectively,which increased significantly compared with group C(P＜0.05).When administered 2 h,the gray value of p-p38 MAPK and NF-κB in group L was 9.23 ±0.53,69.23±5.53,which increased significantly compared with group C (P＜0.05),and the gray value of PL group was 6.32±0.35,which was significantly lower than that of group L.Administration of 3 h,p-p38 MAPK,NF-κB gray value in group L was 11.13±0.23,71.13±5.23 respectively,which increased significantly compared with group C(P＜0.05).p-p38 MAPK,NF-κB gray value was 8.95±0.21,56.95±5.21 respectively in group PL,which decreased significantly compared with group L(P＜0.05).Administration of 6 h,p-p38 MAPK,NF-κB gray value was 12.16±0.20,73.16±4.20 respectively in group L,which increased significantly compared with group C (P＜0.05).p-p38 MAPK,NF-κB gray value was 9.65±0.32,58.65±4.32 respectively in group PL,which decreased significantly compared with the L group (P＜0.05).Administration of 12 h,p-p38 MAPK,NF-κB gray value was 18.19±0.31,91.19±6.31 respectively,which increased significantly compared with group C (P＜0.05).p-p38 MAPK,NF-κB gray value in group PL was 12.65±0.12,63.36±5.12 respectively,which decreased significantly compared with group L(P＜0.05).Conclusion LPS stimulating HUBECs can increase the expression of p-p38 MAPK and NF-κB,and inhibit this increase after Propofol injection may be one of the mechanisms of Propofol anti-inflammation. 2018 Vol. 25 (9): 4-6转11 [Abstract] ( 169 ) HTML (33 KB)  PDF  (0 KB)  ( 26 ) 7 Effect of Metformin combined with Compound Danshen Dripping Pills treating metabolic syndrome induced by antipsychotic drugs XIE Sui-feng;YU Jun;ZHONG Yuan-hui; XU Bing-cong;CAI Li-li;GAO Shuai;WANG Zhao Objective To discuss preliminarily the influence of single or combined use of Metformin and Compound Danshen Dripping Pills on the body mass and glycolipid metabolism in patients with schizophrenia.Methods One hundred and twenty inpatients with schizophrenia accompanying with metabolic syndrome in our hospital from September 2016 to May 2017,and the patients were all in line with the diagnostic criteria of schizophrenia in the International Classification of Diseases(ICD-10).According to the random number table method,patients were divided into the Metformin combined with Compound Danshen Dripping Pills group (the following was referred to as the joint group),Compound Danshen Dripping Pills group and Metformin group,and there were 40 cases in each group.Body weight,body max index (BMI),fasting glucose,fasting insulin,triglyceride,total cholesterol,high-density lipoprotein (HDL),low-density lipoprotein (LDL),apolipoprotein A1,apolipoprotein B,and C peptide as well as the score of positive and negative syndrome scale (PANSS)and treatment emergent symptom scale (TESS)were assessed at baseline,3 and 6 months among three groups.Results After 6 months treatment,the joint group,Metformin group,and Compound Danshen Dripping Pills group had significant improvement in body weight,BMI,fasting glucose,total cholesterol and fasting insulin compared with beforetreatment(P＜0.05).Similarly,the joint group and Compound Danshen Dripping Pills group had significant improvement in HDL and LDL compared with before treatment(P＜0.05).The degree of decline of body mass,BMI and fasting insulin level in the joint group was the highest,followed by the Compound Danshen Dropping Pills group and Metformin group.There were no significant difference regarding clinical efficacy and the incidence of adverse reaction (P＞0.05).Conclusion Single or combined use of Metformin and Compound Danshen Dripping Pills can effectively and safely improve the body weight increasing and metabolic disturbance of metabolic syndrome induced by antipsychotic drugs.The curative effect of Metformin combined with Compound Danshen Dripping Pills is the best. 2018 Vol. 25 (9): 7-11 [Abstract] ( 300 ) HTML (38 KB)  PDF  (0 KB)  ( 29 ) 12 Exploration of the influence factors of synthesis efficiency of 2-deoxy-2-[fluorine-18]fluorine-D-glucose CHEN Li-guang;LIANG Ming-quan;DENG Qing-rong;LEI Zhen-shan Objective To investigate the influence factors of synthesis efficiency of 2-deoxy-2-[fluorine-18]fluorine-D-glucose (18F-FDG).Methods The influence of radiation loss,different hydrolysis methods and time as well as the nucleophilic reaction temperature and time of different nucleophilic reactions on the synthetic efficiency were analyzed.Results The synthetic efficiency of was increased when the content of water decreased.The best reaction conditions of 18F-FDG:the nucleophilic reaction temperature was 110℃,the time was 180 s and acid hydrolysis time was 9 min.Conclusion The synthesis efficiency of18F-FDG could be improved by controlling the technological parameters such as acetonitrile water content,reaction temperature and time. 2018 Vol. 25 (9): 12-15 [Abstract] ( 152 ) HTML (37 KB)  PDF  (0 KB)  ( 28 ) 16 Clinical effect analysis of preoperative interventional therapy for cervical cancer DING Lin-Kang;LIU Bing-Yuan;JIANG Li-Ping Objective To explore the clinical value of uterine arterial chemoembolization in the treatment of cervical carcinoma.Methods Thirty patients with cervical cancer of stageⅡa-Ⅱb treated in our hospital from March 2014 to August 2016 were selected as the study group,who underwent radical hysterectomy followed by uterine arterial chemoembolization.Thirty patients who underwent radical resection of cervical cancer at the same period were selected as the control group.The short-term efficacy,tumor shrinkage,the volume of intraoperative blood loss,operation time and postoperative pathological results were analyzed.Results After interventional treatment,the clinical symptoms of patients were relieved in different degrees,the remission rate was 100%,and the total effective rate of short-term curative effect for interventional therapy was 76.67%.There was no significant difference in the effective rate of intervention between study group at stageⅡa andⅡb (P＞0.05).The tumor diameter in the study group after interventional treatment was lower than before intervention,and the difference was statistically significant (P＜0.05).The volume of intraoperative blood loss in the study group was less than that in the control group,and the rate of cancer metastasis of lymph node,vascular tumor thrombus and para uterine infiltration after operation were all lower than those in the control group,and the difference was statistically significant(P＜0.05).ConclusionInterventional therapy before radical resection of cervical cancer can effectively reduce the size of tumor,the short-term curative effect is obvious,and can improve the clinical symptoms of patients,effectively inhibit the cancer metastasis of lymph node,vascular tumor thrombus,and para uterine invasion,and reduce the risk of operation. 2018 Vol. 25 (9): 16-19 [Abstract] ( 154 ) HTML (37 KB)  PDF  (0 KB)  ( 30 ) 20 Determination of Adapalene related substances in Adapalene Gel by HPLC ZHU Ya-lian;XIAO Xue-cheng;CUI Kai-yu;WANG Xiao-piao Objective To establish the HPLC method for determination related substances of Adapalene in Adapalene Gel.Methods Chromatographic column ORBAX Eclipse XDB-C18(4.6 mm×250 mm,5 μm)was used,and the mobile phase A was glacial acetic acid-water(0.1∶100),and the mobile phase B was acetonitrile-tetrahydrofuran(65∶35)to conduct the gradient elution.The wavelength of detection was 270 nm,the temperature of column was 30°C,the sampling amount was 100 μl,and the flow rate was 1.2 ml/min.Results Adapalene was well separated from various impurity.The solution of Adapalene Gel was stable in 12 hours.The limit of quantification of impurity A,B,C and D was 0.38 ng,0.56 ng,3.75 ng and 1.5 ng respectively,and the detection limit was 0.11 ng,0.17 ng,1.12 ng and 0.45 ng.Adapalene showed a good linear relationship between peak area and concentration in the concentration range of 0.0225-0.1125 g/ml,and the regression equation was y=9.9714x+0.003906(r=0.9998).Conclusion This method is simple and feasible to determine the related substances of Adapalene in Adapalene Gel. 2018 Vol. 25 (9): 20-24 [Abstract] ( 170 ) HTML (40 KB)  PDF  (0 KB)  ( 37 ) 25 Research progress of the application of Dexmedetomidine in cardiac surgery with cardiopulmonary bypass ZHONG He-jiang;YANG Tian-de Dexmedetomidine,a highly selective α2agonist,provides dose-dependent sedation,analgesia,and anti-sympathetic activity.It alleviates the stress associated with anesthesia and surgery,without obvious respiratory depression.Dexmedetomidine as an anesthetic adjunct was widely used in clinical anesthesia.Recently,studies have shown that perioperative administration of dexmedetomidine decreases the need for anesthetics and maintains hemodynamic stability.It induces myocardial protection and anti-inflammatory effects and significantly reduces the incidence of perioperative cardiovascular events in patients undergoing cardiac surgery with cardiopulmonary bypass.Therefore,perioperative dexmedetomidine improves the recovery of the patients undergoing cardiac surgery.This paper mainly elaborate the clinical use of dexmedetomidine in patients undergoing cardiac surgery with cardiopulmonary bypass. 2018 Vol. 25 (9): 25-28 [Abstract] ( 155 ) HTML (37 KB)  PDF  (0 KB)  ( 28 ) 29 Application of PD-1/PD-L1 inhibitors in the treatment of non-small cell lung cancer GONG Jin;LI Jian-qiang Lung cancer is the most common malignant tumor in the world,and the mortality of lung cancer still is the first in all of tumors.Non-small cell lung cancer has a large proportion of the lung cancer.However,the current treatments for non-small cell lung cancer are limited and ineffective.Therefore,it is urgent to find a more effective treatment for non-small cell lung cancer.Programmed death-1 (PD-1)and its ligand,an important immunosuppressive molecule,whose ligand is PD-L1,has been discovered for over 20 years.In recent years,with the deepening research of programmed death-1(PD-1)and its ligand(PD-L1),the new treatment methods on the immune checkpoint has been gradually applied in clinical and gotten great achievements.Among them,the PD-1/PD-L1 inhibitors used to treat non-small cell lung cancer that have been significant clinical effect for the advanced patients.This paper reviewed the clinical effect and application of PD-1/PD-L1 inhibitors used commonly for non-small cell lung cancer. 2018 Vol. 25 (9): 29-32 [Abstract] ( 168 ) HTML (37 KB)  PDF  (0 KB)  ( 35 ) 33 Research progress on the relationship and intervention of common senile disease with cognitive impairment WANG Yu;SHI Zhen-dong;ZHANG Hua With the trend of population aging exacerbating,the incidence of cognitive impairment(CI)in the elderly is increasing.The cause of senile CI is very complex,not only the common nervous system diseases,but also many other diseases outside the nervous system.This should arouse the attention by both doctors and patients.Early intervention and prevention with risk factors of CI will actively prevent the disease,while comprehensive treatment and management of patients with CI will improve the prognosis.This review will summarize the relationship and the intervention strategies of common senile disease with CI. 2018 Vol. 25 (9): 33-35 [Abstract] ( 163 ) HTML (31 KB)  PDF  (0 KB)  ( 33 ) 36 Clinical study on the treatment of unstable angina pectoris in traditional Chinese medicine LIU Rui CHENG Xiao-yu Unstable angina pectoris(UA)is a group of clinical syndromes that are mainly manifested by pressing pain in front of the heart.Coronary atherosclerosis and vascular stenosis lead to insufficient blood supply and cardiomyocytes acute ischemia,eventually result in the occurrence of unstable angina.Unstable angina belongs to Chinese medicine thoracic,true painca tegory.The traditional Chinese medicine consider that due to the heart of qi、blood,Yin and Yang are damaged caused stagnation of qi,Blood stasis,phlegm turbidity and cold coagulation arise imperceptibly.Unstable angina is a kind of disease which asthenia in origin and asthenia in superficiality,Western Medicine mainly treatments for unstable angina pectoris are dual antiplatelet aggregation,anti-platelet aggregation,stable atherosclerotic plaques and Protect vascular endothelium,etc.The treatment of UA by TCM has remarkable characteristics.This paper discusses the classification and characteristics of unstable angina pectoris. 2018 Vol. 25 (9): 36-40 [Abstract] ( 252 ) HTML (46 KB)  PDF  (0 KB)  ( 36 ) 41 Clinical analysis of coagulation function indexes of neonates of different ages CHEN Li-zhen;XIE Ke-kai;MAI Ji-hong Objective To study the clinical difference of blood coagulation function in preterm infants of different age.Methods A total of 100 premature infants admitted to our hospital from April 2016 to September 2017 were selected as research subjects.According to their age of admission,they were divided into 0 to ＜2 d,2 to 7 d （excluding 7 d）,7 to 14 d （excluding 14 d）,14 d above four groups.The coagulation function indexes such as prothrombin time(PT),activated partial prothrombin time(APTT),thrombin time(TT)and fibrinogen(FIB)in 12 hours after admission were compared.Results Premature infant FIB was (1.88±0.61)g/L,was significantly lower than that of full-term infants(reference neonatal science)(2.69±0.34)g/L,the differences were statistically significant(P＜0.05).With the increase of preterm infants′age,PT,APTT and TT shortened,and FIB increased,the differences were statistically significant(P＜0.05).Conclusion There are differences in coagulation function indexes among children at different ages.The smaller the age is,the easier the coagulation function is.The monitoring of coagulation function is beneficial for early intervention and treatment,and improve the quality of life of premature infants. 2018 Vol. 25 (9): 41-42转48 [Abstract] ( 166 ) HTML (25 KB)  PDF  (0 KB)  ( 33 ) 43 Comparative study on pressure release ventilation and pulmonary protective ventilation for acute respiratory distress syndrome PAN Jian;MA Jun-wu;DENG Xiu-fan;HUANG Xiao-ming Objective To explore the effects of airway pressure release ventilation(APRV)and lung protective ventilation(SIMV)on acute respiratory distress syndrome.Methods 94 patients with acute respiratory distress syndrome admitted to our hospital from November 2016 to November 2017 were selected as the research subject,and were divided into two groups(n=47)according to the random number table method.Pulmonary protective ventilation was performed in the SIMV group and airway pressure release ventilation was applied in the APRV group.The arterial blood gas index,airway mechanics,hemodynamics and lung injury were compared between the two groups before ventilation and 2 days after ventilation.Results There was no significant difference in PaO2/FiO2,ELWI,Ppeak and Pmean between the two groups before ventilation (P＞0.05).After ventilation,however,the PaO2/FiO2in the SIMV group was shown to be lower than that in the APRV group,while the ELWI,Ppeak and Pmean were higher than that in the APRV group,the differences were statistically significant(P＜0.05).There was no significant difference in HR,CVP,MAP and Murray score between the two groups before ventilation(P＞0.05).After 2 days of ventilation,the HRV,CVP and Murray scores in the SIMV group were shown to be higher than those in the APRV group,and the MAP was lower than that in the APRV group,the differences were statistically significant(P＜0.05).Conclusion Compared with SIMV,APRV is more effective in the treatment of patients with acute respiratory distress syndrome,which is beneficial to their respiratory function and lung recruitment.It can also improve the hemodynamics of the patients and is better for their recovery. 2018 Vol. 25 (9): 43-45 [Abstract] ( 158 ) HTML (30 KB)  PDF  (0 KB)  ( 28 ) 46 Effect evaluation of multidisciplinary comprehensive pulmonary rehabilitation on senile patients with pneumoconiosis ZHOU Gong-hao;OU Wen-bin Objective To evaluate the application effect of multidisciplinary pulmonary rehabilitation in elderly patients with pneumoconiosis.Methods From January 2015 to November 2017,76 elderly patients with pneumoconiosis who were admitted into our hospital were enrolled in this study.According to different rehabilitation methods,they were evenly divided into experimental group and reference group,38 cases in each group.In the reference group,conventional rehabilitation was provided,while in the experimental group,multidisciplinary comprehensive pulmonary rehabilitation was adopted.The quality of life scores and mean 6-minute walking distance before and after rehabilitation in the two groups were observed.Results The score of quality of life before rehabilitation was(2.7±0.4)points in experimental group,and(2.8±0.5)points in the reference group without a significant difference(P＞0.05).The quality of life score of the experimental group after rehabilitation was(2.5±0.1)points,which was lower than that in the reference group of(2.7±0.6)points with a statistical difference(P＜0.05）.The mean 6-minute walking distance beofre rehabilitation was(286.3±31.0)m in the experimental group,and(285.2±32.0)m in the reference group without a significant difference(P＞0.05).The mean 6-minute walking distance after rehabilitation was(365.8±36.0)m in the experimental group,which was significantly higher than that in the reference group of(281.0±30.5)m with a statistical difference (P＜0.05）.Conclusion Application of multidisciplinary comprehensive pulmonary rehabilitation can obtain a remarkable effect in elderly patients with pneumoconiosis. 2018 Vol. 25 (9): 46-48 [Abstract] ( 156 ) HTML (26 KB)  PDF  (0 KB)  ( 29 ) 49 Clinical study of Calcitriol combined with Zoledronic Acid in the prevention of adjacent vertebral fracture after vertebroplasty SUN Jing-hua;RUAN Wen-li;WANG Wen-hui Objective To investigate the clinical effect of Calcitriol combined with Zoledronic Acid in the prevention of adjacent vertebral fracture after vertebroplasty.Methods From February 2012 to June 2014,256 elderly patients with thoracolumbar vertebral compression fracture were divided into experimental group(n=113)and control group(n=143)according to whether they were willing to use Calcitriol combined with Zoledronic Acid or not after PKP surgery.In the control group,only calcium supplement was used,while in the experimental group,on the basis of the control group,Calcitriol combinedwithcontinuousZoledronicAcidwasadded.Bone mineral density(BMD),vertebral height,and local Cobb angle were measured before medication and the third year after medication in all patients.The number of refracture was calculated in the two groups.Results In the experimental group,the BMD in the third year after medication was significantly higher than that before treatment(P＜0.05).There was no significant difference in the height of vertebral body or Cob angle before and after medication(P＞0.05).The BMD of the control group before and after treatment was displayed a significant difference(P＜0.05).The height of vertebral body in control group was shorter than that before medication，and the Cob angle was larger compared with prior treatment，which were in great differences(P＜0.05).Compared with the control group after medication,the BMD was better and the vertebral height was larger in the experimental group after therapy,after medication,the Cob angle was small than that in the control group (P＜0.05).In the experimental group,there was 1 case occurred with adjacent vertebral fracture,but 11 cases in the control group.Conclusion Combination of Calcitriol and Zoledronic Acid in continuous sufficient doses can strengthen the adjacent vertebral BMD in the elderly patients with brittle fracture of thoracolumbar spine after PKP surgery,prevent fracture,and improve the long-term clinical effect. 2018 Vol. 25 (9): 49-52 [Abstract] ( 145 ) HTML (36 KB)  PDF  (0 KB)  ( 29 ) 53 Application effect of Alprostadil in the treatment of patients with chronic obstructive pulmonary disease and chronic cor pulmonale YI Xiao-li;LI Shi-xiong;ZHEN New-xian Objective To investigate the effect of Prostaglandin(PGE1)on pulmonary arterial pressure and pulmonary function in patients with chronic obstructive pulmonary disease(COPD)complicated with chronic cor pulmonale.Methods From May 2016 to October 2017,62 patients with COPD complicated with chronic cor pulmonale in our hospital were randomly divided into two groups,31cases in each group.The control group was received routine treatment and the study group was treated with Alprostadil.The clinical effect of two groups was observed and analyzed.Results Before treatment,FEV1/FVC and FEV1of two groups were no significant differences between forced expiratory volume of one second,forced vital capacity,forced expiratory volume of one second and pulmonary arterial pressure(P＞0.05).After treatment,FEV1/FVC and FEV1were all expected higher in the study group,the pulmonary arterial pressure was lower than that in the control group(P＜0.05).There was no significant difference in pulmonary capillary permeability between the two groups before treatment(P＞0.05),and after treatment,pulmonary capillary permeability was better in the study group than in the control group(P＜0.05).Before treatment,there was no significant difference between the two groups in the partial pressure of oxygen(PaO2)and the oxygenation index[P(A-A)O2](P＞0.05).After treatment,PaO2was higher in the study group than that in the control group,P(A-a)O2was lower than that in the control group,the differences were statistically significant （P＜0.05）.Conclusion The application of Alprostadil in COPD patients with chronic pulmonary heart disease can achieve the exact effect and improve the pulmonary function. 2018 Vol. 25 (9): 53-55 [Abstract] ( 174 ) HTML (32 KB)  PDF  (0 KB)  ( 31 ) 56 The effect of Ticagrelor on acute ST-elevation myocardial infraction JIANG Yang;ZHENG Xiao-qun Objective To evaluate the effect of Ticagrelor on acute ST-elevation myocardial infraction.Methods 120 patients with STEMI admitted to our hospital from January 2016 to January 2017 were performed primary PCI.According to the difference of treatment methods,the patients were divided into Ticagrelor group and Clopidogrel group.At the third month after procedure,the incidence of bleeding and major adverse cardiovascular events(MACE)between two groups were compared.Results In Ticagrelor group,the incidence of MACE was 3.3%,which was lower than that in the Clopidogrel group(8.3%),but no significant difference was observed between both groups(P＞0.05).Additionally,the incidence of bleeding,major without,minor was no significant difference was found between both groups(P＞0.05).Conclusion Ticagrelor has a tendency to reduce the incidence of MACE,without the increase of the bleeding incidence,in elderly patients with STEMI. 2018 Vol. 25 (9): 56-58 [Abstract] ( 148 ) HTML (27 KB)  PDF  (0 KB)  ( 29 ) 59 Evaluation of retroperitoneal laparoscopic pyeloplasty for the treatment of ureteropelvic junction stenosis in children LIU Dian-yong;ZHANG Shuai;GAO Li-juan objective To evaluate the clinical effect of retroperitoneal disconnection pyeloplasty in the treatment of ureteral junction stenosis in children.Methods From October 2015 to October 2016,82 cases of ureteral junction stricture were studied in our hospital.They were randomly divided into study group and reference group according to random number table method,41 cases in each group.The patients in the control group were treated with open dissected pyeloplasty,and those in the study group were treated by retroperitoneal laparoscopic dissecting pyeloplasty.The operative time,intestinal function recovery time,hospitalization time and intraoperative blood loss were compared between the two groups.And the success rate，postoperative complications and recurrence of hydronephrosis were compared between the two groups.Results The operative time,intestinal function recovery time,hospitalization time and intraoperative blood loss in the study group were significantly lower than those in the control group (P＜0.05).The success rate of operation,the incidence of postoperative complications and the recurrence rate of hydronephrosis in the study group were 95.1%,7.3%and 2.4%respectively,there was no significant difference compared with the control group(P＞0.05).Conclusion Laparoscopic pyeloplasty for the treatment of ureteral junction stricture in children was performed in a short time,and the patients recovered quickly after operation.It is a safe and effective surgical treatment method,which is worthy of extensive clinical application. 2018 Vol. 25 (9): 59-61 [Abstract] ( 173 ) HTML (28 KB)  PDF  (0 KB)  ( 35 ) 62 Clinical study on surgical treatment of non-puerperal mastitis ZHANG Hong-wei;YAO Ning;LIU Yu-fei;CUI Xiao;WANG Juan Objective To study the clinical situation of surgical treatment of non-puerperal mastitis(NPM).Methods In our hospital from March 2015 to March 2017 were selected 44 cases of NPM patients as the research object,according to the time of surgical treatment were divided into A group(25 cases)and B group(19 cases),from the onset to surgery,group A was less than or equal to 1 months,group B was more than 1 month,were treated with antibiotics for a week after breast tumor surgery,the clinical situation were compared between the two groups.Results Before surgery,the age,lactation history,nipple,nipple discharge,skin irritation,tumor diameter,leukocytosis,pathological type of patients in two groups had no statistical significant differences (P＞0.05),after surgery,there was no significant difference in postoperative infection,time of hospitalization,postoperative recurrence rate,and postoperative satisfaction of the breast(P＞0.05).Conclusion Early surgical treatment of NPM,which can avoid the disease continues to increase,development caused by mass abscess or sinus formation and pain caused by treatment,can shorten the course of disease and reduce adverse drug reactions caused by treatment,physical and mental health of patients with better protection 2018 Vol. 25 (9): 62-64转73 [Abstract] ( 139 ) HTML (31 KB)  PDF  (0 KB)  ( 27 ) 65 Application of Sufentanil combined with Remifentanil in patients undergoing general anesthesia for intubation and its influence on hemodynamics and stress response JIANG Jin-hong;ZHANG Ding-xiu;ZHENG De-zhi;YU Hong Objective To explore the application of Sufentanil combined with Remifentanil in patients undergoing general anesthesia for intubation and its influence on hemodynamics and stress response.Methods From April 2014 to April 2017,62 patients undergoing intubation in general anesthesia in our hospital were evenly divided into combination group and control group by computer randomization,31 cases in each group.Patients in the combination group were given Sufentanil and Remifentanil,and those in the control group,Remifentanil alone was provided.The hemodynamics includingheartrate(HR),meanarterialpressure(MAP),andoxyhemoglobinsaturation(SpO2)and stress indicators of epinephrine(E),norepinephrine(NE)before anesthesia(T0),after intubation(T1),tube drawing(T2)were observed between the two groups.The postoperative visual analogue scale(VAS)score between the two groups was also compared.Results Compared with T0,the levels of HR,E and NE at T1and T2were all increased,and the indicators in the combination group were lower in comparison with those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in MAP at T0,T1and T2,the differences were not statistically significant(P＞0.05).The MAP levels at T1and T2 were elevated compared with that at T0,and those indexs of the combined group were lower than those of the control group,the differences were statistically significant(P＜0.05).There was no significant difference in SpO2at different time points (P＞0.05).Four hours after surgery,the VAS score in the combination group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Combination of Sufentanil and Remifentanil can effectively maintain the hemodynamic stability,decreasethe stress level and relieve postoperative pain in patients undergoing intubation in general anesthesia. 2018 Vol. 25 (9): 65-67 [Abstract] ( 155 ) HTML (34 KB)  PDF  (0 KB)  ( 32 ) 68 Anesthetic effects of ultrasound guided lower extremity nerve block in ankle surgery WANG Hai-dong;ZHANG Jie;LU Li-hua Objective To analyze the anesthetic effects of ultrasound guided lower extremity nerve block in ankle surgery.Methods A total of 94 ankle patients undergoing ankle surgeries in our hospital from October 2016 to October 2017 were divided into research group(n=47)and reference group(n=47)according to a double-blind method.Patients in the reference group were provided with lumbar anesthesia,while in the research group,ultrasound guided lower extremity nerve block was adopted.The motor score,sensory score,anesthetic effect and occurrence of complications were comparatively analyzed.Results There was no significant difference in motor score or sensory score in different grading between the two groups(P＞0.05).In the research group,the onset time of postoperative sensory block,the onset time of motor block,the maintenance of motor block,the duration of postoperative analgesia were longer than those in the reference group,while the the time for getting out of bed was shorter than that in the reference group,the differences were statistically significant(P＜0.05).The total incidence of complications in the research group was 6.38%,which was lower than that in the reference group accounting for 21.27%,the difference was statistically significant(P＜0.05).Conclusion Compared to lumbar anesthesia,ultrasound-guided lower extremity nerve block has a better anesthetic effect on patients with ankle surgery by effectively shortening the onset time of the drug and the time to get out of bed,prolonging the duration of drug maintenance and analgesia,and reducing the occurrence of complications,which has a higher value of clinical application. 2018 Vol. 25 (9): 68-70 [Abstract] ( 144 ) HTML (27 KB)  PDF  (0 KB)  ( 39 ) 71 The application value of transvaginal color doppler ultrasound testing of trophoblast blood flow signal in early pregnancy with cesarean scar LONG Zheng-xi;LUO Li-hua Objective To analyze the application value of transvaginal color doppler ultrasound testing of trophoblast blood flow signal in early pregnancy with cesarean scar.Methods Forty-four patients with uterine scar pregnancy were selected from February 2013 to January 2017 in our hospital.All patients were given transvaginal color Doppler ultrasound detection,and compared with postoperative pathological examination results,the diagnostic coincidence rate of transvaginal color Doppler ultrasound detection was calculated,and the ultrasonographic characteristics were analyzed.Results Ultrasound examination showed that 40 cases were in accordance with postoperative pathological examination results,4 cases were missed diagnosis,clinical diagnosis coincidence rate was 90.91%(40/44).Gestational sac was embedded in uterine scar in 28 cases,mass in 10 cases and 6 cases of gestational sac were completely in the middle and lower uterine cavity or uterine cavity.Conclusion In the early diagnosis of pregnancy with cesarean scar,transvaginal color doppler ultrasound testing plays a significant role.In terms of pregnancy with cesarean scar,its sonographic feature is mainly demonstrated by the blood flow signal of the existence of low-resistent trophoblast around the gestation sac,which is really important to early accurate diagnosis of cesarean scar pregnancy. 2018 Vol. 25 (9): 71-73 [Abstract] ( 139 ) HTML (28 KB)  PDF  (0 KB)  ( 25 ) 74 Diagnostic value of transabdominal ultrasonography in recurrent metastasis after radical operation of colon cancer YU Hui-lin;WANG Jing-bo Objective To analyze the diagnostic value of transabdominal ultrasonography in recurrent metastasis after radical operation of colon cancer.Methods A total of 100 patients with suspected recurrence and metastasis after radical resection of colon cancer diagnosed and treated in our hospital from October 2015 to August 2016 were randomly divided into control group and observation group with 50 cases in each group.CT examination was performed in the control group and transabdominal ultrasound examination was performed in the observation group.The detection rate,sensitivity and specificity of the two groups were compared.Results The detection rate of patients in the observation group was higher than that in the control group，the difference was statistically significant(P＞0.05).The sensitivity and specificity of patients in the observation group were 95.56%and 80.00%,which were higher than those in the control group(77.78%and 60.00%),and the differences were statistically significant(P＞0.05).Conclusion Transabdominal ultrasonography can significantly improve the detection rate,sensitivity and specificity in the patients with recurrent metastasis after radical resection of colon cancer,which is worthy of further promotion and application in the patients with recurrent metastasis after radical operation of colon cancer. 2018 Vol. 25 (9): 74-76 [Abstract] ( 162 ) HTML (29 KB)  PDF  (0 KB)  ( 25 ) 77 Application value of ultrasonography in the diagnosis of lower extremity venous thrombosis ZHANG Zhao-qing Objective To analyze the value of ultrasound in the diagnosis of venous thrombosis of the lower extremity.Methods Fifty patients with venous thrombosis of lower limbs diagnosed in our hospital from February to December in 2017 were selected as the research objects,and underwent ultrasound examination and digital subtraction angiography(gold standard).The diagnosis results of the two methods were compared.Results The diagnosis rate of digital subtraction angiography was 100.00%(50/50)and ultrasound was 100.00%,there was no significant difference between the two groups(P>0.05).Conclusion The application of ultrasonography in the diagnosis of venous thrombosis of lower extremity has high diagnosis rate,plus its advantages of noninvasiveness and simple operation,which have good application and promotion value. 2018 Vol. 25 (9): 77-79 [Abstract] ( 181 ) HTML (29 KB)  PDF  (0 KB)  ( 33 ) 80 Effect of 3%Hypertonic Saline atomization inhalation combined with Budesonide and Salbutamol in the treatment of moderate to severe bronchiolitis in children YU Dong-hui;LIU Ying-hui;LI Yong-hong;YU Li-ying Objective To observe the therapeutic effect of 3%Hypertonic Saline atomization inhalation combined with Budesonide and Salbutamol in the treatment of moderate to severe bronchiolitis in children.Methods From November 2013 to November 2016,451 children with bronchiolitis,aged from 1 month to 2 years,who were admitted to the department of pediatrics in the People′s Hospital in Langfang City were selected as the study subjects.The subjects were randomly divided into the control group(n=227)and the treatment group(n=224)by random number table method.Two groups of patients were treated by conventional methods.In the control group,children were treated with Budesonide combined with Salbutamol inhalation,and the treatment group were treated on the basis of the control group plus 3%Hypertonic Saline.The clinical efficacy,hypoxia symptom score,duration of symptoms,hospital stay and adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the treatment group(86.2%)was higher than that in the control group(80.6%),and the difference was statistically significant(P＜0.05).After treatment 1,3,5 days,the scores of hypoxia symptom in the treatment group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The duration of coughing continued,the wheezing continued,the recovery time of blood gas and the time of sound disappeared in the treatment group shorter than those in the control group,and the differences were statistically significant(P＜0.05).The average length of hospital stays in the treatment group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The 3%Hypertonic Saline inhalation combined Budesonide and Salbutamol in the treatment of moderate to severe bronchiolitis in children is remarkable.This treatment method has certain clinical application value for the treatment of children with bronchiolitis. 2018 Vol. 25 (9): 80-82转86 [Abstract] ( 154 ) HTML (34 KB)  PDF  (0 KB)  ( 33 ) 83 Effect of Nimodipine combined with Xingnaojing for the treatment of hypertensive intracerebral hemorrhage GENG Yu Objective To investigate the effect of Nimodipine on serum neurotransmitters in hypertensive intracerebral hemorrhage and its prognostic.Methods From June 2016 to June 2017,108 patients with hypertensive intracerebral hemorrhage were diagnosed in our hospital were selected as subjects.They were divided into observation group(56 cases)and control group (52 cases)according to different medication schemes.The patients in the observation group were treated with Nimodipine combined with Xingnaojing,and the control group was treated with the treatment of Edaravone and Xingnaojing,and two courses of treatment were successively treated.The serum neurotransmitter indexs,neurofunctional indexs,survival quality score and therapeutic effect were compared between the two groups.Results After two courses of treatment,the vasopressin([7.18±1.59]ng/L),glial fibrillary acidic protein([7.28±2.16]ng/L),glutamate([77.57±3.59]μmol/L)μmol/L,aspartic acid([28.69±3.67]μmol/L),S100B protein([0.44±0.06]ng/L),neuropeptide Y([177.45±11.07]μg/L),neuron-specific enolase([10.19±2.65]mg/L)in the observation group were significantly lower than those in the control group ([10.27±3.01]ng/L,[13.24±2.62]ng/L,[84.34±6.52]μmol/L,[37.95±4.95]μmol/L,[0.87±0.31]ng/L,[196.34±12.64]μg/L,[16.08±4.12]mg/L),while the γ-aminobutyrate([4.25±1.02]μmol/L)and brain origin neurotrophic factor([6.21±1.26]ng/mL)in the observation group were significantly higher than those in the control group ([3.41±0.58]μmol/L,(5.13±1.05]ng/mL),and the differences were statistically significant(P＜0.05).The total score of world health organization survival quality measurement scale (WHOQOL-100)in the observation group was (78.55±7.53)points,which was significantly higher than that in the control group (71.05±6.15)points,and the difference was statistically significant(P＜0.05).The effective rate of treatment in the observation group(89.29%)was significantly higher than that in the control group(80.77%),and the difference was statistically significant(P＜0.05).Conclusion Nimodipine and Xingnaojing are suitable for the treatment of hypertensive intracerebral hemorrhage.It can effectively regulate the expression level of serum neurotransmitters,promote the recovery of nerve function,and have a good prognosis. 2018 Vol. 25 (9): 83-86 [Abstract] ( 130 ) HTML (34 KB)  PDF  (0 KB)  ( 34 ) 87 Effect comparison of Low Molecular Weight Heparin combined with Magnesium Sulfate and conventional Magnesium Sulfate in the treatment of early-onset preeclampsia CHEN Ai-ni;WANG Mei-lan;ZHANG Li-ping Objective To study the clinical effect of Low Molecular Weight Heparin combined with Magnesium Sulfate in the treatment of patients with early-onset preeclampsia.Methods A total of 160 early-onset preeclampsia patients admitted to our hospital from August 2015 to November 2016 were selected as research objects.They were divided into research group and control group according to a random number table method,with 80 cases each group.In the research group,Low Molecular Weight Heparin combined with Magnesium Sulfate were used,while in the control group,Magnesium Sulfate was adopted.The blood pressure,coagulation function and renal function index were compared in the two groups,and the complications of the two groups were also compared.Results Before and after treatment,the prothrombin time,activated partial thromboplastin time and fibrinogen level of patients in two groups were compared,and the differences were not statistically significant(P＞0.05).Before treatment,the systolic blood pressure,diastolic blood pressure and D-dimer were not statistically different(P＞0.05),while after therapy,the levels of the systolic blood pressure,diastolic blood pressure and D-dimer in the research group were all lower than those in the control group (P＜0.05).There was no significant difference in the incidence of complications between the two groups(P＞0.05).There was no significant difference in renal function before treatment between the two groups(P＞0.05).The levels of urea nitrogen,uric acid and serum creatinine after therapy of patients in two groups were compared,and the differences were not statistically significant(P＞0.05).In the research group,the levels of 24-hour urinary protein and urinary protein/creatinine were both lower compared with those in the control group,and the differences were statistically significant(P＜0.05).Conclusion For earlyonset preeclampsia patients,Low Molecular Weight Heparin combined with Magnesium Sulfate can obtain a great effect,significantly improve coagulation and renal function and safeguard patient′s prognosis. 2018 Vol. 25 (9): 87-89 [Abstract] ( 167 ) HTML (29 KB)  PDF  (0 KB)  ( 21 ) 90 Clinical effect of Cefonicid combined with Xuebijing Injection in the treatment of senile patients with community acquired pneumonia Li Chang-juan Objective To observe the clinical effect and safety of Cefonicid combined with Xuebijing Injection in the treatment of senile patients with community acquired pneumonia(CAP).Methods From February 2016 to August 2017,112 senile patients with CAP treated in our hospital were divided into the control group and the observation group according to the random digital table method,and each group was 56 cases.The control group was treated with Cefonicid for intravenous infusion,and the observation group was treated with Xuebijing Injection on the basis of the control group.At the same time,the basic diseases were actively treated,symptomatic treatment and support treatment were carried out.The clinical effect,inflammation markers and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 96.4%,which was significantly higher than that in control group(76.8%),and the difference was statistically significant(P＜0.05).The levels of white blood cell count,high sensitivity C-reactive protein and proealcitonin 14 days after treatment of the two groups were statistically lower than those before treatment,while the indicators of patients in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).Both groups had no serious adverse reactions.Conclusion The clinical effect and inflammation markers of Cefonicid combined with Xuebijing Injection in the treatment of senile patients with CAP is better than Cefonicid alone,and there was no serious adverse reaction. 2018 Vol. 25 (9): 90-92 [Abstract] ( 158 ) HTML (30 KB)  PDF  (0 KB)  ( 34 ) 93 Efficacy of Medopa combined with Pramipexole in the treatment of Parkinson′s disease WANG Lei Objective To investigate the effect of Medopa combined with Pramipexole on cognitive function and quality of life(QOL)in patients with Parkinson′s disease(PD).Methods From January 2016 to January 2018,126 patients with PD admitted in our hospital were selected as subjects.They were randomly divided into Medodopa group (n=63)and Pramipexole group(n=63).Medopa group was treated with Medopa,while the Pramipexole group was treated with Pramipexole on the basis of above treatment.The therapeutic effect were compared between the two groups.Results After treatment,the score of Parkinson′s scale Ⅲ (UPDRSⅢ)was significantly lower than that before treatment,the Montreal cognitive scale(MoCA)and simple mental state evaluation scale(MMSE)were significantly lower than those before treatment,whlie the score of UPDRSⅢin Pramipexole group was significantly lower than that in Medopa group,the scores of MoCA and MMSE were significantly higher than those in Pramipexole group,the differences were statistically significant(P＜0.05).After treatment,two groups of patients with levels of serum glutathione (GSH)and glutathione peroxidase(GSH-Px)were significantly higher than those before treatment,the level of reactive oxygen species (ROS)was lower than that before treatment,and the levels of GSH and GSH-Px in the Pramipexole group were significantly higher than those in Medopa group,the ROS level was significantly lower than that in Medopa group,the differences were statistically significant(P＜0.05).The physical,psychological,independence,social relationship and environment of the Pramipexole group were all higher than those of the Medopa group,the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in Pramipexole group was 6.35%,and it was 12.70%in the Medopa grou,and the difference was not statistically significant(P＞0.05).Conclusion The clinical symptoms of PD patients can be effectively alleviated by the combination of Medopa and Pramipexole.It can improve its cognitive function and quality of life,clinical application is safe and effective. 2018 Vol. 25 (9): 93-96 [Abstract] ( 136 ) HTML (33 KB)  PDF  (0 KB)  ( 23 ) 97 Effect comparison of the Erythromycin,Azithromycin sequential therapy and Azithromycin alone in the treatment of mycoplasma pneumonia in children MA Xing-wei;WU Wei-sen;CHEN Pei-qun;MA Ya-hong;LIN Ni-yang Objective To explore the effect of Erythromycin and Azithromycin sequential therapy in the treatment of mycoplasma pneumonia.Methods Altogether 200 cases of children with mycoplasma pneumonia who were treated in our hospital from September 2015 to August 2017 were selected as subjects and randomly divided into two groups,100 cases in each group.The children of two groups were both given conventional symptomatic treatment,the children in the control group were treated with Azithromycin alone,while the children in the observation group were treated with Erythromycin and Azithromycin sequential therapy.The total effective rate,adverse reaction rate,treatment time and hospitalization duration were compared between the two groups.Results After treatment,the total effective rate in the observation group(97.0%)was higher than that in the control group(88.0%),and the difference was statistically significant(P＜0.05).During the treatment,the total incidence of adverse reactions in the observation group (4.0%)was lower than that in the control group(13.0%),and the difference was statistically significant(P＜0.05).The treatment time and hospitalization duration of the children in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).ConclusionThe sequential therapy of Erythromycin and Azithromycin can help to reduce the adverse drug reactions of children with mycoplasma pneumonia,shorten the treatment time,and make the patients recover early. 2018 Vol. 25 (9): 97-99 [Abstract] ( 147 ) HTML (29 KB)  PDF  (0 KB)  ( 31 ) 100 Clinical effect observation of Clomiphene combined with traditional Chinese medicine compound Ovulation Decoction in the treatment of anovulatory infertility YAO Wei-zhi;PENG Wen Objective To investigate the clinical effect of Clomiphene combined with traditional Chinese medicine compound Ovulation Decoction in the treatment of anovulatory infertility.Methods Ninety-two cases of patients with anovulatory infertility treated in our hospital from September 2015 to June 2017 were selected as subjects,and were divided into control group and observation group by random number table method,with 46 cases in each group.The control group were only treated with Clomiphene,while the observation group were treated with Clomiphene combined with traditional Chinese medicine compound Ovulation Decoction.Then the clinical effect,pregnancy rate and ovulation rate of the two groups of patients were compared.Results The total effective rate in the observation group (93.48%)was higher than that in the control group(69.57%),and the difference was statistically significant(P＜0.05).The endometrial thickness in the observation group was (12.12±1.31)mm,which was greater than that in the control group of(7.46±1.21)mm,the number of mature follicle in the observation group was (1.81±0.47),which was more than that in the control group of(1.63±0.37),the ovulation rate(89.13%)and pregnancy rate(50.00%)in the observation group were higher than those in the control group (60.87%,60.87%),and the differences were statistically significant(P＜0.05).Conclusion The use of Clomiphene combined with traditional Chinese medicine compound Ovulation Decoction in the treatment of anovulatory infertility which clinical effect is prominent,and can effectively improve the pregnancy rate and ovulation rate,thus it is worthy extensive clinical promotion. 2018 Vol. 25 (9): 100-102 [Abstract] ( 137 ) HTML (28 KB)  PDF  (0 KB)  ( 29 ) 103 Clinical effect of Ziwuliuzhu acupuncture sticking and oral administration of Chinese herbs in pattern identification in the treatment of knee osteoarthritis GE Rui;WANG Qing;DAI Bo;XIANG Wen-dong;ZHANG Ying-zi Objective To investigate the clinical effect of Ziwuliuzhu acupuncture sticking and oral administration of Chinese herbs in pattern identification in the treatment of knee osteoarthritis.Methods From June 2016 to June 2017,150 patients with osteoarthritis of the knee treated in our hospital were selected as the subjects,and randomly divided into the observation group and the control group,75 cases in each group.The control group was treated with western medicine treatment.The observation group was divided into four syndromes according to TCM syndrome type,and treated with oral decoction combined with topical Ziwuliuzhu acupuncture according to the method of syndrome types.Results The WOMAC score of the two groups before treatment had no significant difference(P＞0.05).At 1,3 and 6 months after treatment,the WOMAC scores in the observation group were significantly lower those in the control group(P＜0.05).There was no significant difference between the two groups of patients before treatment in CRP and IL-6(P＞0.05).CRP and IL-6 in the observation group after treatment of 1,3,6 months were significantly lower than those in the control group (P＜0.05).Conclusion The clinical curative effect of acupoint application on ideal Ziwuliuzhu and oral Chinese medicine in the treatment of knee osteoarthritis is conducive to the improvement of WOMAC score of patients,reduce the levels of inflammatory factors,which is worthy of clinical application. 2018 Vol. 25 (9): 103-105 [Abstract] ( 137 ) HTML (29 KB)  PDF  (0 KB)  ( 28 ) 106 Effect of traditional Chinese medicine fumigation in the treatment of early swelling of ankle closure fracture LI Qiong-zhong;CHEN Cui-ling;YANG Xiao-li Objective To explore the clinical effect of traditional Chinese medicine fumigation in the treatment of early swelling of closed ankle fracture.Methods A total of 80 patients with ankle fractures treated in our hospital from January to June 2017 were selected as the subjects,and randomly divided into observation group and control group,40 cases in each group.The patients in the control group were treated with routine nursing measures.The patients in the observation group were treated with traditional Chinese medicine smoked agents on the basis of routine nursing.The clinical effect was compared between the two groups after treatment.Results After treatment,the swelling and pain of the limbs in the observation group were significantly better than the control group,the difference was statistically significant(P＜0.05).The total effective rate of the patients in the observation group (100.0%)was significantly higher than that in the control group(80.0%),the difference was statistically significant(P＜0.05).Conclusion Chinese medicine fumigation has a good clinical effectt on patients with closed ankle fracture,which can effectively improve the body swelling and pain,it is worthy promotion in clinic. 2018 Vol. 25 (9): 106-108 [Abstract] ( 126 ) HTML (28 KB)  PDF  (0 KB)  ( 31 ) 109 Effect analysis of warming-needle moxibustion in the treatment of sacroiliitis CAI Shao-ping Objective To analyze the curative effect of warming-needle moxibustion in the treatment of sacroiliitis.Methods From January 2014 to April 2017,64 patients with sacroiliitis treated in our hospital were selected and evenly divided into control group(32 cases)and observation group(32 cases)by computer randomization.In the control group,western medicine was used,while in the observation group,warming-needle moxibustion was adopted.Pain remission rate,quality of life,and recovery of sacroiliac joint function were compared between the two groups.Results The total remission rate of pain in the observation group was 96.88%,which was higher than that in the control group accounting for 71.88%,with a statistical difference (P＜0.05).The quality of life score after 6-month treatment in the observation group was(84.12±2.29)points,which was higher than that in the control group ([71.19±2.01]points),with a significant difference(P＜0.05).The score of sacroiliac joint function after 6-month treatment in the observation group was(86.69±2.14)points,which was higher than that in the control group([75.51±2.16]points),with a significant difference(P＜0.05).Conclusion Warming-needle moxibustion in the treatment of sacroiliitis can obtain a reliable effect. 2018 Vol. 25 (9): 109-111 [Abstract] ( 151 ) HTML (27 KB)  PDF  (0 KB)  ( 33 ) 112 Analysis of pathogen type and drug resistance changes of sputum in the hospitalized patients in respiratory department LU Li-miao;XIONG Liu-xin;LI Shu-ying;LIANG Qi-lan Objective To investigate the changes of pathogens and Antibiotic resistance in sputum of respiratory inpatients.Methods The positive specimens of sputum from July 2015 to June 2017 in the hospitalized patients in the Department of respiration in our hospital were selected,the results of culture were identified by Shanghai Fuxing instrument.Antibiotic sensitivity test was performed by MIC and K-B methods.WHONET 5.4 software was used for drug sensitivity analysis.Results Among 1300 sputum samples,160 strains of pathogenic bacteria were detected,and the detection rate was 12.3%.Among them,26 cases were Gram positive strains (16.2%),105 cases were Gram-negative strains(65.6%),and there were 29 strains of fungi(18.2%).The isolated pathogens from the top 3 isolates were Klebsiella pneumoniae in 37 strains(23.1%),fungi in 29 strains(18.2%),Pseudomonas aeruginosa in 25 strains(15.6%)respectively.The antimicrobial agents with lower drug resistance of Gram-negative bacteria included Cefoperazone/Sulbactam and Imipenem,etc.Antimicrobial agents with low resistance to Staphylococcus aureus included Linezolid and Teicoplanin and Vancomycin.Compared with July 2015 to June 2016,the drug resistance was in a rising trend from July 2016 to June 2017.Conclusion The sputum pathogens in the patients in respiratory department are mainly gram-negative bacteria,and they are significantly resistant to commonly used antibiotics,which is gradually in an increasing trend 2018 Vol. 25 (9): 112-113转116 [Abstract] ( 153 ) HTML (23 KB)  PDF  (0 KB)  ( 35 ) 114 Clinical significance of detection of plasma D-dimer and fibrinogen in the diagnosis of disseminated intravascular coagulation CAI Jin-mei;HUANG Xue-zhen;ZHANG Rui-xiong;WU Sheng-xing Objective To investigate the clinical value of plasma D-dimer and fibrinogen in the diagnosis of disseminated intravascular coagulation(DIC).Methods A total of 30 DIC patients admitted into our hospital from January 2014 to May 2017 were selected as the observation group.The other 30 healthy women for physical examinations were enrolled in the same period as the control group A and another 30 normal pregnant women with suspected DIC was classified into the control group B.The plasma D-dimer and fibrinogen levels were compared among the three groups.Results Before treatment,the levels of plasma D-dimer and fibrinogen in the observation group were(2301.52±1367.94)μg/L and (1.23±0.34)g/L respectively,while those in the control groups A and B were(143.67±35.12)μg/L and(2.76±0.47)g/L,and(874.98±451.20)μg/L and (2.11±0.36)g/L accordingly.The D-dimer level in the observation group was significantly higher,but fibrinogen was lower than those in the other two groups,with statistical differences(P＜0.05).The D-dimer level in the control group B was higher compared to the control group A,the fibrinogen level of the control group B was lower compared to the control group A,with statistical significance (P＜0.05).Conclusion The detections of plasma D-dimer and fibrinogen have high clinical values in the diagnosis of DIC and the diagnostic sensitivity is strong,which is worthy of clinical application and promotion. 2018 Vol. 25 (9): 114-116 [Abstract] ( 136 ) HTML (26 KB)  PDF  (0 KB)  ( 31 ) 117 The value of C reactive protein,procalcitonin,peripheral blood white blood cell count and prealbumin in the diagnosis of severe pneumonia CHEN Yu-chong Objective To explore the value of C reactive protein(CRP),procalcitonin(PCT),peripheral blood white blood cell(WBC)count and prealbumin (PA)in the diagnosis of severe pneumonia.Methods A total of 45 cases of severe pneumonia patients in our hospital from February 2014 to May 2017 were selected as the detection group,then 40 cases of no severe pneumonia patients of pulmonary infection were selected as the internal control group,then 40 cases of physical examination were selected as the external control group.The changing and positive rate of the three group subject investigated CRP,PCT,WBC and PA were detected.Results The level of CRP,PCT,WBC of the detection group were higher than those of the external control group and the internal control group,the level of PA of the detection group were lower than those of the external control group and the internal control group,the level of CRP,PCT,WBC of the internal control group were higher than those of the external control group,the level of PA of the internal control group were lower than those of the external control group,the positive rate of CRP,PCT,WBC and PA in the detection group were higher than those in the internal control group and the external control group,the positive rate of CRP,PCT,WBC and PA in the internal control group were higher than those in the external control group,the difference were statistical significance (P＜0.05).Conclusion The CRP,PCT,WBC and PA in the diagnosis of severe pneumonia have higher value,which could enhance monitor of CRP,PCT,WBC and PA in pulmonary infection patients. 2018 Vol. 25 (9): 117-119 [Abstract] ( 175 ) HTML (27 KB)  PDF  (0 KB)  ( 35 ) 120 Infection and characteristics of common pathogenic microorganisms in cervical secretions and leucorrhea in female genitourinary tract infection XU Jie-ling;FANG Yun-xiang;YU Jin-yan Objective To investigate the infection and characteristics of cervical secretions including Neisseria gonorrhoeae(NG),Chlamydia trachomatis(CT),Ureaplasma urealyticum(UU)and common pathogenic microorganisms from leucorrhea in genitourinary tract infection women.Methods From January 2015 to September 2017,a total of 100 female patients with genitourinary tract infection admitted to our hospital were studied.By real-time fluorescence quantitative polymerase chain reaction(FQ-PCR),conventional culture,Gram staining,the infection and characteristics of cervical secretions including NG,CT,and UU and common pathogenic microorganisms from leucorrhea were observed.Results The positive rate of UU was significantly higher than that of NG and CT,with statistical differences(P＜0.05).In detection of leucorrhea,the positive rate of Gram-positive dialister bacteria was higher(P＜0.05).In the positive detection rate of mixed infection,only mixed type of CT+UU was detected.For positive detection of leucorrhea mixed infection,compared with other types,the positive detection rate of mixed infection of Gram-positive dialister bacteria+Gram-negative bacteria was more prominent(P＜0.05).Conclusion NG,CT,UU of cervical secretions and common pathogenic microorganisms of leucorrhea in female genitourinary tract infection patients all display varying degrees of infection.The detection rate is also significantly different.After mixed infection,it is more complicated,suggesting that it should be paid attention in clinic. 2018 Vol. 25 (9): 120-122 [Abstract] ( 131 ) HTML (27 KB)  PDF  (0 KB)  ( 32 ) 123 Analyze of the multi-drug resistance of the pathogenic bacteria during the microbiological test in our hospital in 2014-2017 PAN Gui-Yi Objective To analyze the multi-drug resistance of the pathogenic bacteria during the microbiological test in our hospital in 2014-2017.Methods A total of 12 306 specimen delivered from 2014 to 2017 in our hospital were selected.The Bio Mérieux VITE2-Compact drug sensitivity analyzer and the microbiological identification instrument were used to take the drug sensitivity test and identification.The multi-drug resistance of the microbiological strains taken in 2014-2017 were evaluated.Results For 12 306 specimen,there were 2000 samples of pathogenic bacteria;the positive detection rate of pathogenic bacteria was 16.3%of which the top three samples included 412 blood specimen (26.9%),280 secretion specimen (17.5%)and 304 sputum specimen (17.0%).There were 403 samples of multi-drug resistant pathogenic bacteria included 136 strains(33.7%)in the respiratory medicine department,120 strains(29.8%)in the cardio-thoracic surgery department,30 strains(7.4%)in the orthopedic surgery department,43 stains(10.7%)in the oncology department,40 strains(9.9%)in the orthopedic surgery department and 23 strains(5.7%)in the burns department and 11 strains(2.8%)in the gastroenterology department.According to the drug resistance analysis of the pathogenic bacteria,the Acinetobacter baumanmii of gram-negative bacteria had the highest drug resistance,followed by Enterobacter cloacae and Escherichia coli.The gram-positive bacteria of Staphylococcus epidermidis and Staphylococcus aureus had the highest drug resistance.Conclusion During the microbiological test in 2014-2017,the gram-negative bacteria have the highest multi-drug resistance.The control and prevention of the nosocomial infection and the reasonable application of the anti-bacterial agents are beneficial to improve the medical treatment quality and reduce the drug resistance of the pathogenic bacteria. 2018 Vol. 25 (9): 123-125 [Abstract] ( 145 ) HTML (26 KB)  PDF  (0 KB)  ( 28 ) 126 Analysis of the application value of serum procalcitonin combined with C-reactive protein in the diagnosis of sepsis WANG Guo-rong Objective To explore the application value of serum procalcitonin (PCT)combined with C-reactive protein(CRP)in the diagnosis of sepsis.Methods A total of 90 cases of patients with sepsis who treated in our hospital from August 2017 to August 2014 were selected as case group,and they were divided into sepsis group,severe sepsis group and septic shock group according to the severity degree of the disease,30 cases in each group.At the same time,30 cases of health examination in our hospital were selected as control group.The levels of PCT and CRP were compared between the each group.Results The level of serum PCT and CRP in case group were higher than those in control group,and the difference were statistically significant(P＜0.05).The levels of serum PCT and CRP in severe sepsis group and septic shock group were higher than those in sepsis group,and the difference were statistically significant(P＜0.05).The level of serum PCT and CRP in septic shock group was higher than that in severe sepsis group,and the difference were statistically significant(P＜0.05).The sensitivity and specificity of combined diagnosis were higher than those of single diagnosis,and the difference were statistically significant(P＜0.05).Conclusion Serum PCT and CRP have important clinical significance in the diagnosis of sepsis.The diagnostic value of combined detection is higher,and it is worthy of clinical promotion and application. 2018 Vol. 25 (9): 126-128 [Abstract] ( 175 ) HTML (29 KB)  PDF  (0 KB)  ( 31 ) 129 Analysis on the security using risk of Chinese patent medicine based on the literature research SU Shuang;WANG Jing-hong;XIA Kun Objective To investigate the safety use status of Chinese patent medicine,to excavate the hidden dangers existed in the processof storage,dispensing,distribution and using of Chinese patent medicine,to provide reference for the safe and rational use of Chinese patent medicine.Methods Chinese patent medicine,rational use,storage,dispensing,unreasonable use and so on were selected as the key words to search the relevant literature of CNKI,Wangfang and VIP and other datebases and the literatures were analyzed and sorted.Results The main problem in the storage process was difficult to meet the storage requirements of drug specification,ect.The main problem existing in the process of dispensing was unreasonable prescription not being intercepted,ect.In the process of drug dispensing,the main problem was error dispensing,ect.In the using process,there are some problems such as dialectical medication is not accurate,ect.Conclusion There are many security risks in the storage,dispensing and using process of Chinese patent medicine,only by carrying out risk control to every link involved in the use of Chinese patent medicine can we minimize the hidden dangers in each link and ensure the safety of medication with high quality pharmaceutical care. 2018 Vol. 25 (9): 129-132 [Abstract] ( 109 ) HTML (40 KB)  PDF  (0 KB)  ( 39 ) 133 Analysis of filling quality on the first page of medical records based on electronic medical records YANG Yan-mei Objective To review the filling quality of the first page of electronic medical records,and to analyze the reasons for defects and put forward corrective measures.Methods A total of 19 974 pieces of the first page of medical records of the patients who were discharged from January 2017 to March 2018 were retrieved from the electronic medical records.The filling quality of the basic information,diagnosis information,surgery information and other information in the first page were reviewed respectively and analyzed by classification.Results The defect rate of the first page of medical records was 2.34%.The defect mainly focused on the basic information (56.33%),and the defect rate of hospitalization information,diagnosis information,accordance and surgery information was 12.09%,14.08%,2.56%and 14.94%respectively.Conclusion The filling defects of the first page of electronic medical records in our hospital are more. 2018 Vol. 25 (9): 133-135 [Abstract] ( 136 ) HTML (27 KB)  PDF  (0 KB)  ( 29 ) 136 Application effect of humanism principle in nursing management in rehabilitation department CONG Su-lan Objective To explore the application effect of humanism principle in nursing management in rehabilitation department,to provide a theoretical basis for the optimization of nursing management scheme in rehabilitation department.Methods A total of 180 patients admitted into in rehabilitation department of our hospital from October 2016 to October 2017 were selected as the research object and they were divided into the observation group and control group according to the random number method.Patients in the control group were given the routine nursing intervention while patients in the observation group were given humanism nursing intervention guided by the humanism principle.Selfknowledge,adaptive ability,behavior laziness and depression were compared between the two groups,and satisfaction degree of nursing in patients was investigated.Results In the discharge,the self-knowledge score of the experimental group was(7.34±1.23)points,which was higher than that of the control group([5.12±2.92]points),and the adaptive ability score of the experimental group was(8.42±1.32)points,which was higher than that of the control group([5.29±1.03]points),and the score of behavioral laziness was(4.94±1.45)points,which was lower than that of the control group([7.22±2.32]points),and the differences were statistically significant(P＜0.05).In the discharge,the depression score of the experimental group was(36.94±1.80)points,which was lower than that of the control group([46.92±2.34]points),and the difference was statistically significant(P＜0.05).In the discharge,the satisfaction degree of nursing in patients of the experimental group(76.67%)was higher than that of the control group (56.67%),and the difference was statistically significant(P＜0.05).Conclusion Humanism nursing conducted in the nursing of rehabilitation department can improve the patients′self-knowledge and adaptive ability,reduce the degree of behavior laziness and depression,and improve the satisfaction degree of nursing of patients. 2018 Vol. 25 (9): 136-138 [Abstract] ( 163 ) HTML (27 KB)  PDF  (0 KB)  ( 36 ) 139 Application effect of 5S management in clinical nursing management LIANG Hong-li;XIAO Hui-qiong;XU Su-fan;LIN Xin-xia;LIU Xian-tuan;LIAN Jin-feng Objective To standardize the management of wards,improve the efficiency of nurses,and ensure the quality and safety of nursing.Methods From January 2016 to February 2017,100 nurses in our hospital were selected as the research objects,and divided into the control group and the research group according to different nursing management intervention methods,50 cases in each group.The control group was given routine management measures,and the research group was given 5S management intervention.The five constant quality control examination score and the grasping state for the thimerosal compound concentration of the workers were compared before and after the two groups of management.Results There was no significant difference in the quality control between the two groups before the implementation of the management intervention(P＞0.05).After the implementation of the management intervention,the two groups of quality control scores were improved,and the research group was higher than that in the control group,there was significant difference in the quality control between the two groups after the implementation of the management intervention(P＜0.05）.The difference of the grasping state for the thimerosal compound concentration of the two groups of workers before the implementation of the management intervention was not statistically significant(P＞0.05）.After the implementation of the management intervention,the grasping state for the thimerosal compound concentration of workers in the research group(92.00%)was which was greatly improved,the difference of the grasping state for the thimerosal compound concentration of the works between the two groups after the implementation of the management intervention was statistically significant(P＜0.05）.Conclusion The implementation of 5S can guarantee the quality and safety of nursing. 2018 Vol. 25 (9): 139-141 [Abstract] ( 139 ) HTML (29 KB)  PDF  (0 KB)  ( 33 ) 142 Analysis on the effect of improvement of process management on the quality of nursing services in obstetrics and gynecology and reducing the incidence of nursing defects RONG Guo-qin Objective To study and analyze the effect of improvement of process management on the quality of nursing services in obstetrics and gynecology and reducing the incidence of nursing defects.Methods A total of 400 patients who were hospitalized in the department of obstetrics and gynecology in our hospital from January 2016 to June 2017 were selected and randomly divided into study group and control group according to the random number table method,200 cases in each group.The control group was given conventional process management,and the research group was adopted a sound process management.The satisfaction rate of nursing service quality and the incidence rate of nursing defects in two groups were observed and compared.Results The satisfaction degree of nursing work in the study group was significantly higher than that in the control group,and the difference was statistically significant (P＜0.05）;the incidence rate of nursing defects in the study group was significantly lower than that in the control group,and the difference was statistically significants(P＜0.05）.Conclusion In the nursing process in the department of obstetrics and gynecology,the improvement of process management helps to improve the quality of nursing work,increase patients′satisfaction,reduce the incidence rate of nursing defects,and is more effective to help restore the patient′s health,and improve the nurse-patient relationship,which is worthy of clinical promotion and application. 2018 Vol. 25 (9): 142-144 [Abstract] ( 167 ) HTML (30 KB)  PDF  (0 KB)  ( 35 ) 145 Application effect of internet+child health management platform in health management of kindergarten ZHU Yu-ning Objective To investigate the application effect of internet+child health management platform in health management of kindergarten.Methods In the jurisdiction of Dali County in Foshan of Guangdong Province,10 kindergartens with internet+child health management platform in Dali county of Foshan in Guangdong from March 2016 to December 2017 were selected as the experimental group,and 10 same-size kindergartens with routine health management were selected as the control group.The complete finish of morning and noon check,human resource allocation of health physicians,the incidence of clustering infectious disease,comprehensive assessment of kindergarten management by functional department,satisfaction of parents,accuracy rate of child growth evaluation were compared between the two groups.Results The full days of morning and noon check in the experimental group were more than those in the control group,and the number of finishing health care workload in the experimental group was less than that in the control group,the differenceswerestatisticallysignifican(P＜0.05).Theincidenceofclusteringcasesofinfectiousdiseasein the experimentalgroup within 1 year was lower than that in the control group,the difference was statistically significan(P＜0.05).The scores of comprehensive assessment and annual assessment in the experimental group were higher than those in the control group,the differences were statistically significan(P＜0.05).The satisfaction of parents and accuracy rate of child growth evaluation in the experimental group were higher than those in the control group,the differences were statistically significan (P＜0.05).Conclusion Internet+child health management platform in health management of kindergarten can effectively increase the health monitoring quality of students,guarantee the work efficiency of health physicians,decrease human resource allocation of health physicians,reduce the incidence of infectious disease,promote the satisfaction of parents and accuracy rate of child growth evaluation. 2018 Vol. 25 (9): 145-147转151 [Abstract] ( 144 ) HTML (32 KB)  PDF  (0 KB)  ( 33 ) 148 Effect of family doctor service on treatment compliance in community diabetic patients WANG Sen-biao Objective To investigate the effect of family doctor service on the treatment compliance of community diabetic patients.Methods A total of 100 diabetic patients who signed community-based family doctor service agreements with this community health service center from January 2015 to January 2017 were selected as the observation group.According to the patients′condition,health intervention and medical management were given by professional medical care team.Another 100 diabetic patients who did not choose family doctor service during the diagnosis were randomly selected as the control group.The self-made questionnaire was applied on the survey of basic knowledge of diabetes and treatment compliance before and after the intervention,and the blood glucose(fasting early morning,postprandial 2 h blood glucose),glycosylated hemoglobin and other indicators were tested before and after intervention,and were statistically analyzed.Results Drug use rate according to doctor′s suggestions,and regular measurement rate of blood glucose after intervention in both groups were significantly higher than those before intervention,while the self-withdrawal rate was significantly lower than that before intervention,the differences were statistically significant(P＜0.05).Drug use rate according to doctor′s suggestions,and regular measurement rate of blood glucose in the observation group were higher than those in the control group.The self-withdrawal rate was significantly lower than that in the control group after intervention,the difference between the two groups was statistically significant(P＜0.05).The awareness rate of diabetes knowledge in the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).The early morning fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin were similar in the two groups before intervention (P＞0.05);compared with the early morning fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in the observation group after intervention were better than those in the control group,the difference was statistically significant(P＜0.05).Conclusion Family doctor service can effectively enhance the mastery of treatment compliance and related knowledge in community diabetic patients and effectively help patients to lower blood sugar. 2018 Vol. 25 (9): 148-151 [Abstract] ( 149 ) HTML (33 KB)  PDF  (0 KB)  ( 40 ) 152 Exploration of MOOC in medical education YUE Gen-quan;WANG Hai-sheng;WU Rui-bing;ZHANG Jian-yu Massive open online course (MOOC)as a new education informatization technology,is a massive open online courses.With the rapid development of MOOC,more and more people′s attention have been aroused in recent years.As a new education mode,MOOC is such different with the traditional education mode.In order to make the medical education better adapt to the reform of learning approach higher medical colleges and universities should actively move into the tide of MOOC.In this paper,we discuss the advantages and defects of MOOC in medical education combined with teaching practice of clinical medicine,by which explore the effect of MOOC on teaching reform in medical education. 2018 Vol. 25 (9): 152-154 [Abstract] ( 138 ) HTML (29 KB)  PDF  (0 KB)  ( 31 ) 155 Effect analysis of nursing clinical teachers on teaching new nurses in central sterile supply department GUO Shao-min Objective To investigate the effect of nursing clinical teachers on teaching new nurses in Central Sterile Supply Department(CSSD).Methods From November 2016 to November 2017,96 new nurses in our CSSD were selected as the research subjects.The new nurses were arranged by the head nurse of CSSD to follow different nursing teachers for 1 week of teaching activities,together with various business learning in CSSD,CSSD nursing training,and propaganda for nursing education.ResultsThe score of self-test in these new nurses after internship was better than that before(P＜0.05).After the internship,the satisfaction rate of new nurses on the internship was 100.0%,higher than that before accounting for 78.1%,with a statistical difference(P＜0.05).Conclusion The effect of nursing clinical teachers on teaching new nurses is remarkable in CSSD,and can significantly improve the satisfaction of the new nurses on clinical teaching. 2018 Vol. 25 (9): 155-157 [Abstract] ( 161 ) HTML (27 KB)  PDF  (0 KB)  ( 32 ) 158 One case report of primitive neuroectodermal tumor and literature review ZHANG Xiao-yang Primitive neuroectodermal tumor(PNET)in the central nervous system is a rare malignant tumor.It is difficult to make a clear diagnosis pre-operatively.This paper reported 1 subtentorial case,and summarized the PNET in the central nervous system that had been reported in the literature in China since 2000.Statistics showed that the incidence of supratentorial cases accounted for the highest and it often occurred in the frontal lobe,and was more commonly seen in male than female,and in children than adults.The disease had short course with high mortality and malignancy.It was easy to relapse and metastasize,and the prognosis was very poor.The pathogenesis of the disease was not completely clear.This disease need profound study and a large amount of data to make analysis and further deepen the understanding of the disease,in order to have a better understanding of the pathology and pathogenesis,thereby improving the diagnosis and treatment level,and promoting the patients′quality of life. 2018 Vol. 25 (9): 158-161 [Abstract] ( 140 ) HTML (34 KB)  PDF  (0 KB)  ( 25 ) 162 Application effect of community psychological intervention in patients with chronic heart failure CHEN Chun-mei Objective To investigate the application effect of community psychological intervention in patients with chronic heart failure (CHF).Methods A total of 120 elderly patients with CHF diagnosed and treated in our hospital from June 2016 to May 2017 were randomly divided into control group and observation group with 60 cases in each group.The control group was treated with ACEI+β receptor antagonist,and the intervention group was treated with community psychological intervention on the basis of the control group.The 6 min walking experiment,self-rating anxiety scale(SAS)score,self-rating depression scale (SDS)score,quality of life and nursing satisfaction of the two groups were compared after the corresponding nursing program intervention for 6 months.Results The scores of quality of life in intervention group were higher than those in control group,the differences were statistically significant(P＜0.05).SAS score and SDS score of intervention group were lower than those of control group,6 min walking test was longer than that of control group,the differences were statistically significant(P＜0.05).The nursing satisfaction of the intervention group was higher than that of the control group,the differences were statistically significant(P＜0.05).Conclusion For CHF patients,the community psychological intervention can obtain a remarkable effect and is worthy of promotion in clinical practice. 2018 Vol. 25 (9): 162-164 [Abstract] ( 133 ) HTML (27 KB)  PDF  (0 KB)  ( 32 ) 165 Application effect analysis of psychological intervention in subacute thyroiditis patients PAN Wei;DENG Wei Objective To investigate the clinical effect of targeted psychological intervention in patients with subacute thyroiditis.Methods Eighty patients with subacute thyroiditis who were treated in our hospital from August 2015 to July 2017 were randomly divided into control group and observation group with 40 patients in each group.Patients in the control group were given oral medication and routine nursing,while patients in the observation group were given intensive psychological intervention on the basis of the control group.erythrocyte sedimentation rate (ESR),VAS pain score,psychological state and total nursing satisfaction score were compared between the two groups.Results One month after nursing,ESR of the two groups was lower than that before nursing,VAS pain score,SAS score,SDS score were lower than that before nursing,the differences were statistically significant(P＜0.05).After one month of nursing,ESR of the patients in the observation group was lower than that in the control group,VAS pain score and SDS score were lower than those in the control group,the differences were statistically significant(P＜0.05).The total score of nursing satisfaction in the observation group [(97.80±7.51]points)was significantly higher than that in the control group([86.42±6.93]points),the difference was statistically significant(P＜0.05).Conclusion Psychological intervention for the treatment of subacute thyroiditis can significantly ameliorate the patient′s negative emotions such as anxiety and depression,relieve pain,and benefit for the improvement of clinical efficacy,which is worthy of clinical application and promotion. 2018 Vol. 25 (9): 165-167 [Abstract] ( 180 ) HTML (29 KB)  PDF  (0 KB)  ( 31 ) 168 The influence of psychological nursing intervention on the anxiety of patients with digestive endoscopy YUAN Yu-chan;CHEN Qu-bo;ZHU Bao-qin Objective To explore the effect of psychological nursing on stem pre endoscopy patients′anxiety.Methods A total of 270 patients with digestive endoscopy diagnosed and treated in our hospital from July 2016 to June 2017 were selected as the research object,and divided into control group and observation group according to the different methods of nursing and the voluntary of the patients,135 cases in each group.The control group was given conventional nursing method,while the observation group was given psychological nursing method.Before and after nursing,anxietyself-rating scale(SAS),self-rating depression scale (SDS)and test results were compared between the two groups.Results Before nursing,the scores of SDS and SAS in the two groups were compared,the differences were no statistically significant(P＞0.05).After nursing,SAS and SDS scores in the observation group were significantly lower than those in the control group and before nursing,the differences were statistically significant(P＜0.05),and the effect of digestive endoscopy in the observation group was better than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Applying psychological nursing to patients undergoing digestive endoscopy can help relieve patients′inner pressure,effectively reduce patients′pain during examination,and is conducive to the smooth development of the examination.It is worthy of wide application in clinic. 2018 Vol. 25 (9): 168-170 [Abstract] ( 152 ) HTML (29 KB)  PDF  (0 KB)  ( 30 ) 171 Analysis of columnar balloon papilla dilatation applied in ERCP lithotripsy and nursing cooperation LIU Yu-lan;WANG Qiao-an;LI Mei-lian Objective To explore the application of columnar balloon papilla dilatation in endoscopic retrograde cholangiopancreatography(ERCP)lithotripsy and its nursing cooperation.Methods A total of 80 cases of ERCP lithotomy in our hospital from January 2016 to October 2017 were selected and divided into control group and observation group by drawing lots,40 cases in each group.All patients were treated with three-level columnar balloon papillary dilation，on this basis,the patients in control group were treated with routine nursing intervention and the patients in observation group were treated with targeted operation combined with nursing intervention.Then the retrograde infection rate,onetime success rate,stone removal success rate and complication rate were compared between the two groups.Results The success rate of stone removal and one-time success rate in the observation group were higher than those in the control group,and the retrograde infection rate of biliary tract in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).After nursing,the total satisfaction of patients in the observation group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Targeted surgery combined with nursing for columnar balloon papilla dilatation of ERCP in patients can obtain a significant effect. 2018 Vol. 25 (9): 171-173 [Abstract] ( 156 ) HTML (30 KB)  PDF  (0 KB)  ( 36 ) 174 Influence analysis of stage change nursing intervention on quality of life of chronic renal failure hemodialysis patient YANG Yue-qing;ZENG Chun-yan;DUAN Yan-hong;PAN Zhi-yi Objective To analyze the effect of stage change nursing intervention on the quality of life in patients with chronic renal failure hemodialysis.Methods A total of 76 patients with chronic renal failure diagnosed and treated in our hospital from January 2016 to September 2017 were divided into control group and observation group by doubleblind randomized method,38 cases in each group.Patients in both groups were treated by hemodialysis,while patients in the control group were treated by routine nursing,while patients in the observation group were treated with stage change nursing intervention,continuously for 90 d.The nursing effect of the two groups was analyzed.Results The observation group before the intervention SF-36 the dimensions of quality of life scores with the control group,the difference was not statistically significant(P＞0.05);After 90 days of intervention,the scores of SF-36 quality of life in the observation group were significantly higher than those in the control group and before intervention(P＜0.05).The difference was statistically significant(P＜0.05).The observation group before the intervention of anxiety and depression scores were comared with the control group,and the difference was not statistically significant(P＞0.05).The observation group after the intervention of anxiety and depression scores were significance lower than those in the control group，the differences were statistically significant(P＜0.05).Conclusion Stage change nursing intervention can significantly improve the quality of life of patients with chronic renal failure and improve their negative mental state,so as to ensure the treatment effect. 2018 Vol. 25 (9): 174-176转179 [Abstract] ( 136 ) HTML (31 KB)  PDF  (0 KB)  ( 36 ) 177 Clinical effect observation of comprehensive nursing intervention on hypertension in the elderly YAO Juan-juan Objective To observe the clinical effect of comprehensive nursing intervention on hypertension in the elderly.Methods A total of 92 elderly hypertensive patients diagnosed and treated in our hospital from January 2016 to September 2017 were selected as the research object,and divided into observation group and control group according to the different nursing methods,46 cases in each group.Both groups were given Irbesartan Tablets in the treatment of hypertension,the control group was given conventional nursing intervention,the observation group was given comprehensive nursing intervention on the basis of the control group.The total effective rate of clinical nursing,blood pressure and lipid changes,clinical nursing prognosis of the two groups were compared.Results The total effective rate of nursing in the observation group was higher than that in the control group (χ2=6.4519,P＜0.05）.The blood lipid and blood pressure in the observation group were significantly lower than those in the control group （P＜0.05）.After treatment,the clinical nursing prognosis of the observation group was significantly better than that of the control group （P＜0.05）.Conclusion In elderly hypertensive patients,comprehensive nursing intervention measures can effectively control and reduce the level of blood pressure in elderly hypertensive patients,blood lipid,improve nursing antihypertensive efficiency,it is effective for improving the prognosis of elderly patients with hypertension,which is worthy of promotion in clinical nursing. 2018 Vol. 25 (9): 177-179 [Abstract] ( 162 ) HTML (28 KB)  PDF  (0 KB)  ( 37 ) 180 Intervention effect of psychological nursing on social function of patients with schizophrenia during convalescence WU Shu-fang;ZOU Rong-hai;WEN Cai-xia;YE Jian-hua Objective To explore the application value of psychological nursing in the rehabilitation of patients with schizophrenia.Methods A total of 92 schizophrenic patients treated in our hospital from May 2015 to March 2017 were selected as the research objects,and were divided into study group and control group by random number table method,with 46 cases in each group.The study group was given psychological nursing,the control group was given routine nursing,and the nursing effect was compared between the two groups.Results There was no significant difference in positive symptoms,negative symptoms,normal mental symptoms and total score between the study group and the control group(P＜0.05).The social function,professional ability,life ability,family function and total score of the study group were lower than those of the control group (P＜0.05).The patients′satisfaction in the study group was significantly higher than that in the control group(P＜0.05).Conclusion Psychological nursing is of great significance in the rehabilitation of patients with schizophrenia,which can effectively promote the recovery of social functions,improve the quality of life and maintain a good doctor-patient relationship. 2018 Vol. 25 (9): 180-182 [Abstract] ( 160 ) HTML (28 KB)  PDF  (0 KB)  ( 36 ) 183 Influence analysis of bundle care on postoperative complications and functional recovery in patients undergoing hip replacement WU Qing-fei Objective To analyze the effect of bundle care on postoperative complications and functional recovery in patients undergoing hip joint replacement.Methods A total of 43 patients with hip arthroplasty treated in our hospital from January 1,2016 to June 30,2017 were selected as the subjects.According to the selected nursing intervention,they were divided into group A(20 cases)and group B(23 cases).Complications and functional recovery of hip joint were compared between the two groups.Results The total incidence of complications in group B was significantly lower than that in group A (P＜0.05).The excellent and good rate of hip function recovery in group B was significantly higher than that in group A (P＜0.05).Conclusion Bundle care can effectively improve the nursing effect of patients undergoing hip replacement and is worthy of promotion. 2018 Vol. 25 (9): 183-185 [Abstract] ( 164 ) HTML (28 KB)  PDF  (0 KB)  ( 32 ) 186 Application effect of fast rehabilitation nursing in transurethral resection of the prostate KUANG Xiao-jun Objective To analyze the clinical effect of fast rehabilitation nursing(FTS)in the patients with transurethral resection of prostate.Methods A total of 116 cases patients with benign prostatic hyperplasia and who treated with transurethral resection of the prostate (transurethral resection of prostate)in our Department from April 2016 to September 2017 were selected as the research subjects.And were randomly divided into observation group (n=60)and control group (n=56)according to the order of admission days.The control group was given only routine nursing,while the observation group was introduced the fast rehabilitation nursing on the basis of routine nursing.Then,the nursing effect were compared between the two groups.Results The statistical comparison showed that the catheter extraction time in the observation group was(6.3±2.4)d,which was lower than that in the control group of(7.8±3.1)d(P＜0.05).The activity time after the operation in the observation group was(1.8±0.5)d,which was lower than that in the control group of(2.4±0.4)d(P＜0.05).The exhaust time after the operation in the observation group was(15.1±3)h,which was lower than that in the control group of(17.2±3.9)h(P＜0.05).The scores of bladder spasticity after the operation for 6 and 24 h in the observation group were lower than those in the control group(P＜0.05).The satisfaction of the patients in the observation group washigherthanthat in the control group,and the difference was statistically significant(P＜0.05).Conclusion The implementation of fast rehabilitation nursing in patients with transurethral resection of the prostate for nursing,which not only shorten the process of patients′rehabilitation,but also promote the establishment of a harmonious nurse-patient relationship. 2018 Vol. 25 (9): 186-188 [Abstract] ( 127 ) HTML (27 KB)  PDF  (0 KB)  ( 30 ) 189 Application effect of high quality nursing in postoperative colon cancer complicated with intestinal fistula in patients with abdominal infection ZHANG Qing-mei;WU Ju-lan;LI Su;HUANG Xiu-ying;CAO Xiao-hua Objective To analyze the application effect of quality of nursing in colon cancer complicated with intestinal fistula in patients with abdominal infection.Methods A total of 84 cases of patients with abdominal infection caused by intestinal fistula from February 2012 to February 2015 in our hospital surgery after resection of colorectal cancer were selected and randomly divided into control group and observation group,42 cases in each group.The control group was treated with routine nursing intervention,and the observation group applied the high quality nursing intervention on the basis of this.The main pathogenic bacteria of the two groups were counted,and the clinical efficacy and quality of life of the two groups were observed and compared.Results Gram-negative bacilli(76.19%)was the main bacterium that causes abdominal infection after colon cancer.The total efficiency of observation group was higher than that of control group(P＜0.05).Six months after surgery,the quality of life in the observation group was higher than that in the control group(P＜0.05).Conclusion Gram-negative bacilli are the main bacteria causing postoperative intestinal fistula infection in colon cancer.Quality nursing can improve the cure rate of postoperative intestinal fistula infection and improve the postoperative quality of life. 2018 Vol. 25 (9): 189-191 [Abstract] ( 143 ) HTML (29 KB)  PDF  (0 KB)  ( 31 ) 192 Role of continuous nursing in improving the quality of life and disease control of children with bronchial asthma LIU Xiao-li;LIU Bin;WANG Cong-cong;CHI Qiao-mei;YAN Wei-juan Objective To explore the role of continuous nursing in improving the quality of life and disease control of children with bronchial asthma.Methods From July 2016 to July 2017,70 children with bronchial asthma treated in our hospital were selected.By a random number table method,they were evenly divided into experimental group and control group,with 35 cases in each group.The control group adopted the pediatric routine nursing,and the experimental group used continuous nursing on this basis.The two groups of children out of the hospital and the continuation of 6 months after hospital discharge care(CTM)score,the symptoms of asthma control level(ACT)scores and children with quality of life questionnaire(PAQLQ)score were compared,two groups of children with follow-up control of asthma symptoms were compared.Results The CTM scores of the two groups were not statistically significant(P＞0.05),but the CTM scores in the experimental group were significantly higher than those in the control group after 6 months of discharge,with statistically significant difference (P＜0.05).ACT score of children out of the hospital were compared between the two groups,there was no statistically significant difference (P＞0.05),the ACT scores with in 3 months after discharge and 6 months after hospital discharge of experimental group were significantly higher than that of control group,the differences were statistically significant(P＜0.05).Two groups of children in three aspects,such as emotional function,symptoms and activity scores before intervention,there was no statistically significant difference of the scores were compared between the two groups (P＞0.05),the experimental group score was significantly higher than that in the control group after the intervention,the difference was statistically significant(P＜0.05).The total control rate of asthma symptoms in children with asthma in the experimental was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).ConclusionContinuous nursing can significantly improve the quality of life of children with bronchial asthma,effectively control asthma symptoms,prevent recurrence,and promote children′s rehabilitation,which is worthy of clinical promotion. 2018 Vol. 25 (9): 192-194转封三 [Abstract] ( 176 ) HTML (34 KB)  PDF  (0 KB)  ( 36 ) 195 Effect of comprehensive nursing intervention on rehabilitation of patients with hypertensive cerebral hemorrhage LI Yan-jia Objective To investigate the rehabilitation effect of comprehensive nursing intervention in patients with hypertensive cerebral hemorrhage by comparing their different clinical manifestations.Methods A total of 124 hypertensive cerebral hemorrhage patients treated in our hospital from July 2016 to September 2017 were selected as the research objects,and randomly divided into control group and observation group,with 62 cases in each group.Patients in the control group received routine nursing,patients in the observation group received comprehensive nursing intervention,and the related clinical data of patients in the two groups were observed and recorded,including quality of life(QLI),self-care ability (FIM)score and complications.Results QLI and FIM scores before nursing were compared between the two groups,the differences were not statistically significant(P＞0.05);QLI and FIM scores were significantly higher in the two groups after nursing than before nursing,the differences were statistically significant(P＜0.05).QLI and FIM scores in the observation group were significantly higher than those in the control group,the differences were statistically significant(P＜0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The comprehensive nursing intervention can significantly improve the rehabilitation effect in patients with hypertensive intracerebral hemorrhage.It can effectively enhance the patients′self-care ability and promote the recovery of patients,and has remarkable advantages in improving the QLI and reducing the incidence of complications,which is worthy of promotion and application in clinic. 2018 Vol. 25 (9): 195-封三 [Abstract] ( 173 ) HTML (28 KB)  PDF  (0 KB)  ( 30 )

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