低分子量肝素联合硫酸镁和常规硫酸镁治疗早发型子痫前期的效果对比

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Abstract Objective To study the clinical effect of Low Molecular Weight Heparin combined with Magnesium Sulfate in the treatment of patients with early-onset preeclampsia.Methods A total of 160 early-onset preeclampsia patients admitted to our hospital from August 2015 to November 2016 were selected as research objects.They were divided into research group and control group according to a random number table method,with 80 cases each group.In the research group,Low Molecular Weight Heparin combined with Magnesium Sulfate were used,while in the control group,Magnesium Sulfate was adopted.The blood pressure,coagulation function and renal function index were compared in the two groups,and the complications of the two groups were also compared.Results Before and after treatment,the prothrombin time,activated partial thromboplastin time and fibrinogen level of patients in two groups were compared,and the differences were not statistically significant(P＞0.05).Before treatment,the systolic blood pressure,diastolic blood pressure and D-dimer were not statistically different(P＞0.05),while after therapy,the levels of the systolic blood pressure,diastolic blood pressure and D-dimer in the research group were all lower than those in the control group (P＜0.05).There was no significant difference in the incidence of complications between the two groups(P＞0.05).There was no significant difference in renal function before treatment between the two groups(P＞0.05).The levels of urea nitrogen,uric acid and serum creatinine after therapy of patients in two groups were compared,and the differences were not statistically significant(P＞0.05).In the research group,the levels of 24-hour urinary protein and urinary protein/creatinine were both lower compared with those in the control group,and the differences were statistically significant(P＜0.05).Conclusion For earlyonset preeclampsia patients,Low Molecular Weight Heparin combined with Magnesium Sulfate can obtain a great effect,significantly improve coagulation and renal function and safeguard patient′s prognosis.

Key words： Effect comparison Low Molecular Weight Heparin Early-onset preeclampsia Magnesium Sulfate

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	Articles by authors
	CHEN Ai-ni
	WANG Mei-lan
	ZHANG Li-ping

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CHEN Ai-ni,WANG Mei-lan,ZHANG Li-ping. Effect comparison of Low Molecular Weight Heparin combined with Magnesium Sulfate and conventional Magnesium Sulfate in the treatment of early-onset preeclampsia[J]. 中国当代医药, 2018, 25(9): 87-89.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I9/87

[1]	高志伟.硫酸镁联合低分子量肝素治疗早发型子痫前期临床疗效及对妊娠结局的影响[J].医学理论与实践，2016，29（16）：2233-2234.
[2]	方妙红.早发型子痫前期中西医联合期待治疗临床观察[J].中华全科医学，2014，12（6）：947-948，962.
[3]	原昕.比较低分子量肝素联合硫酸镁和常规硫酸镁治疗早发型子痫前期的疗效[J].中国现代药物应用，2017，11（16）：134-136.
[4]	盛玲燕.硫酸镁联合拉贝洛尔治疗早发型重度子痫前期预后及妊娠结局的研究[J].中国妇幼保健，2014，29（25）：4077-4078.
[5]	任丽萍，陈维娜，蔡蓓珺，等.低分子量肝素钙治疗早发型重度子痫前期的临床研究[J].中华妇幼临床医学杂志（电子版），2016，12（5）：576-582.
[6]	孙立敏，郭伟男，王小梅，等.低分子肝素钙联合硫酸镁、盐酸拉贝洛尔治疗早发型子痫前期的研究[J].中国实用医药，2015，10（13）：130-131.
[7]	周文龙，耿鹏.硫酸镁联合小剂量阿司匹林治疗早发型子痫前期的效果及对母婴预后的影响[J].中国实用医药，2016，11（36）：95-97.
[8]	李春秀.早发型子痫前期疾病治疗中施行解痉抗凝疗法的临床价值探究[J].中西医结合心血管病电子杂志，2017，5（8）：45.
[9]	范春芳，王建.硫酸镁与丹参注射液在早发型子痫前期治疗中的应用及其对围产结局的影响[J].中国妇幼保健，2016，31（10）：2078-2080.
[10]	朱红卫.硫酸镁联合低分子肝素治疗早发型子痫前期的疗效观察[J].中国实用医药，2014，9（27）：128-129.
[11]	童重新，邢小芬，乔书花，等.低分子肝素钙联合丹参治疗早发型重度子痫前期的临床疗效分析[J].中华妇幼临床医学杂志（电子版），2014，10（2）：193-198.
[12]	李莉.低分子肝素钠辅助治疗对子痫前期患者凝血功能及肾功能的影响[J].临床心身疾病杂志，2017，23（3）：40-41.
[13]	沈岩金，黄秀琼，林寒梅，等.中西医结合防治脾虚血瘀型子痫前期复发的临床疗效观察[J].云南中医中药杂志，2017，38（2）：21-24.
[14]	彭燕，白洋，王璞，等.硫酸镁联合拉贝洛尔治疗子痫前期的临床效果及对妊娠结局的影响[J].中国妇幼保健，2015，30（30）：5274-5275.
[15]	王珊，张燕.硫酸镁对子痫前期患者血清血管内皮生长因子血管性血友病因子的表达及尿蛋白定量的影响分析[J].山西医药杂志，2016，45（16）：1862-1864.
[16]	郑素梅.硫酸镁联合低分子肝素钙对妊娠子痫患者凝血功能及妊娠结局的影响[J].河南医学研究，2017，26（5）：897-898.