二甲双胍联合复方丹参滴丸治疗抗精神病药物所致代谢综合征的效果

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Abstract Objective To discuss preliminarily the influence of single or combined use of Metformin and Compound Danshen Dripping Pills on the body mass and glycolipid metabolism in patients with schizophrenia.Methods One hundred and twenty inpatients with schizophrenia accompanying with metabolic syndrome in our hospital from September 2016 to May 2017,and the patients were all in line with the diagnostic criteria of schizophrenia in the International Classification of Diseases(ICD-10).According to the random number table method,patients were divided into the Metformin combined with Compound Danshen Dripping Pills group (the following was referred to as the joint group),Compound Danshen Dripping Pills group and Metformin group,and there were 40 cases in each group.Body weight,body max index (BMI),fasting glucose,fasting insulin,triglyceride,total cholesterol,high-density lipoprotein (HDL),low-density lipoprotein (LDL),apolipoprotein A1,apolipoprotein B,and C peptide as well as the score of positive and negative syndrome scale (PANSS)and treatment emergent symptom scale (TESS)were assessed at baseline,3 and 6 months among three groups.Results After 6 months treatment,the joint group,Metformin group,and Compound Danshen Dripping Pills group had significant improvement in body weight,BMI,fasting glucose,total cholesterol and fasting insulin compared with beforetreatment(P＜0.05).Similarly,the joint group and Compound Danshen Dripping Pills group had significant improvement in HDL and LDL compared with before treatment(P＜0.05).The degree of decline of body mass,BMI and fasting insulin level in the joint group was the highest,followed by the Compound Danshen Dropping Pills group and Metformin group.There were no significant difference regarding clinical efficacy and the incidence of adverse reaction (P＞0.05).Conclusion Single or combined use of Metformin and Compound Danshen Dripping Pills can effectively and safely improve the body weight increasing and metabolic disturbance of metabolic syndrome induced by antipsychotic drugs.The curative effect of Metformin combined with Compound Danshen Dripping Pills is the best.

Key words： Metformin Compound Danshen Dripping Pills Schizophrenia Body weight

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	Articles by authors
	XIE Sui-feng
	YU Jun
	ZHONG Yuan-hui
	XU Bing-cong
	CAI Li-li
	GAO Shuai
	WANG Zhao

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XIE Sui-feng,YU Jun,ZHONG Yuan-hui, et al. Effect of Metformin combined with Compound Danshen Dripping Pills treating metabolic syndrome induced by antipsychotic drugs[J]. 中国当代医药, 2018, 25(9): 7-11.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I9/7

[1]	Leucht S，Cipriani A，Spineli L，et al.Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia：a multiple-treatments meta-analysis[J].Lancet，2013，382（9896）：951-962.
[2]	Curtis J，Watkins A，Rosenbaum S，et al.Evaluating an individualizedlifestyleandlifeskillsinterventiontopreventantipsychotic-induced weight gain in first-episode psychosis[J].Early Interv Psychiatry，2016，10 （3）：267-276.
[3]	Wu RR，Zhao JP，Jin H，et al.Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain：a randomized controlled trial[J].JAMA，2008，299（2）：185-193.
[4]	WuRR，ZhangFY，GaoKM，etal.Metformintreatmentofantipsychotic-induced dyslipidemia： an analysis of two randomized，placebo-controlled trials[J].Mol Psychiatry，2016，21（11）：1537-1544.
[5]	蔡东滨，杨欣湖，郑伟，等.预防抗精神病药物所致首发精神分裂症患者体质量增加的研究现况[J].四川精神卫生，2017，30（2）：191-195.
[7]	谢穗峰，钟远惠，喻俊，等.探讨复方丹参滴丸治疗奥氮平所致代谢综合征的疗效及安全性[J].中国实用神经疾病杂志，2017，20（9）：1-4.
[9]	高帅，张瑜良，蔡丽莉，等.阿立哌唑联合奥氮平对精神分裂症患者体质量、糖脂代谢影响的研究[J].四川精神卫生，2015，28（2）：127-130.
[11]	姜雨微，姜文海，马连华，等.瑞舒伐他汀联合行为干预对抗精神病药所致代谢综合征的影响[J].中华精神科杂志，2017，50（4）：295-301.
[6]	Zheng W，Li XB，Tang YL，et al.Metformin for weight gain and metabolic abnormalities associated with antipsychotic treatment：meta-analysis of randomized placebo-controlled trials[J].J Clin Psychopharmacol，2015，35（5）：499-509.
[8]	Toni H，Jennie S，Vijaya S.Quality of Diagnosis and Procedure Coding in ICD-10 Administrative Data[J].Med Care，2006，44（11）：1011-1019.
[10]	Kroeze WK，Hufeisen SJ，Popadak BA，et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypicalantipsychotic drugs[J].Neuropsychopharmacology，2003，28（3）：519-526.
[12]	吴仁容，赵靖平，邵平，等.二甲双胍对奥氮平所致精神分裂症患者体质量增加的影响[J].中华精神科杂志，2008，41（1）：1-4.
[13]	Jarskog LF，Hamer RM，Catellier DJ，et al.Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder[J].Am J Psychiatry，2013，170（9）：1032-1040.
[14]	Baptista T，Uzcátegui E，Rangel N，et al.Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia：a 12-week double-blind，placebo-controlled pilot study[J].Psychiatry Res，2008，159（2）：250-253.
[15]	Chen C H，Huang M C，Kao C F，et al.Effects of adjunctive metformin on metabolic traits in nondiabetic clozapinetreated patients with schizophrenia and the effect of metformin discontinuation on body weight：a 24-week，randomized，double-blind，placebo-controlled study[J].J Clin Psychiatry，2013，74（5）：424-430.
[16]	王莹，张许来，朱道民，等.二甲双胍治疗奥氮平引起的体质量增加的Meta分析[J].中国健康心理学杂志，2014，22（5）：653-656.
[17]	李志猛，李雅忠，刘海军，等.二甲双胍缓释片治疗女性精神分裂症伴发代谢综合征的研究[J].中国健康心理学杂志，2012，20（9）：1290-1291.
[18]	吴小霞，祁富生，朱进才，等.二甲双胍早期干预对非典型抗精神病药物所致精神病患者代谢综合征的预防作用[J].四川精神卫生，2016，29（1）：51-54.
[19]	谭文钟，杨忠，周联军，等.复方丹参滴丸治疗精神分裂症患者糖脂代谢异常的疗效分析[J].吉林医学，2011，32（32）：6819-6820.
[20]	蔡东滨，杨欣湖，郑伟，等.金刚烷胺治疗奥氮平所致精神分裂症患者体质量增加的Meta分析[J].四川精神卫生，2017，30（3）：243-247.
[21]	David H，Le NJ，Margaret H，et al.Mortality in schizophrenia and related psychoses：data from two cohorts，1875-1924 and 1994-2010[J].BMJ Open，2012，2（5）：e000447.