舒芬太尼复合瑞芬太尼在插管全麻手术患者中的应用及对血液动力学和应激反应的影响

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Abstract Objective To explore the application of Sufentanil combined with Remifentanil in patients undergoing general anesthesia for intubation and its influence on hemodynamics and stress response.Methods From April 2014 to April 2017,62 patients undergoing intubation in general anesthesia in our hospital were evenly divided into combination group and control group by computer randomization,31 cases in each group.Patients in the combination group were given Sufentanil and Remifentanil,and those in the control group,Remifentanil alone was provided.The hemodynamics includingheartrate(HR),meanarterialpressure(MAP),andoxyhemoglobinsaturation(SpO2)and stress indicators of epinephrine(E),norepinephrine(NE)before anesthesia(T0),after intubation(T1),tube drawing(T2)were observed between the two groups.The postoperative visual analogue scale(VAS)score between the two groups was also compared.Results Compared with T0,the levels of HR,E and NE at T1and T2were all increased,and the indicators in the combination group were lower in comparison with those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in MAP at T0,T1and T2,the differences were not statistically significant(P＞0.05).The MAP levels at T1and T2 were elevated compared with that at T0,and those indexs of the combined group were lower than those of the control group,the differences were statistically significant(P＜0.05).There was no significant difference in SpO2at different time points (P＞0.05).Four hours after surgery,the VAS score in the combination group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Combination of Sufentanil and Remifentanil can effectively maintain the hemodynamic stability,decreasethe stress level and relieve postoperative pain in patients undergoing intubation in general anesthesia.

Key words： Sufentanil Remifentanil Hemodynamics Stress response

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	JIANG Jin-hong
	ZHANG Ding-xiu
	ZHENG De-zhi
	YU Hong

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JIANG Jin-hong,ZHANG Ding-xiu,ZHENG De-zhi, et al. Application of Sufentanil combined with Remifentanil in patients undergoing general anesthesia for intubation and its influence on hemodynamics and stress response[J]. 中国当代医药, 2018, 25(9): 65-67.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I9/65

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