骨化三醇联合唑来膦酸预防椎体成形术后临近椎体骨折的临床研究

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Abstract Objective To investigate the clinical effect of Calcitriol combined with Zoledronic Acid in the prevention of adjacent vertebral fracture after vertebroplasty.Methods From February 2012 to June 2014,256 elderly patients with thoracolumbar vertebral compression fracture were divided into experimental group(n=113)and control group(n=143)according to whether they were willing to use Calcitriol combined with Zoledronic Acid or not after PKP surgery.In the control group,only calcium supplement was used,while in the experimental group,on the basis of the control group,Calcitriol combinedwithcontinuousZoledronicAcidwasadded.Bone mineral density(BMD),vertebral height,and local Cobb angle were measured before medication and the third year after medication in all patients.The number of refracture was calculated in the two groups.Results In the experimental group,the BMD in the third year after medication was significantly higher than that before treatment(P＜0.05).There was no significant difference in the height of vertebral body or Cob angle before and after medication(P＞0.05).The BMD of the control group before and after treatment was displayed a significant difference(P＜0.05).The height of vertebral body in control group was shorter than that before medication，and the Cob angle was larger compared with prior treatment，which were in great differences(P＜0.05).Compared with the control group after medication,the BMD was better and the vertebral height was larger in the experimental group after therapy,after medication,the Cob angle was small than that in the control group (P＜0.05).In the experimental group,there was 1 case occurred with adjacent vertebral fracture,but 11 cases in the control group.Conclusion Combination of Calcitriol and Zoledronic Acid in continuous sufficient doses can strengthen the adjacent vertebral BMD in the elderly patients with brittle fracture of thoracolumbar spine after PKP surgery,prevent fracture,and improve the long-term clinical effect.

Key words： Vertebroplasty Calcitriol Zoledronic Acid Adjacent vertebra

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	SUN Jing-hua
	RUAN Wen-li
	WANG Wen-hui

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SUN Jing-hua,RUAN Wen-li,WANG Wen-hui. Clinical study of Calcitriol combined with Zoledronic Acid in the prevention of adjacent vertebral fracture after vertebroplasty[J]. 中国当代医药, 2018, 25(9): 49-52.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I9/49

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