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2020 Vol. 27, No. 4
Published: 2020-02-08
4
Early enteral nutrition by pump infusion improving critical hyperglycemia and insulin resistance
WANG Xing-ling LI Yan-yun WU Jia-sheng ZHANG Zhen-guan WU Jia-xin PAN Chao-yong ZHONG You-di ZENG Hui-xia ZHANG Qiao-jun
[Abstract]
Objective
To investigate the effect of continuous nutrition pump infusion for early enteral nutrition（EEN）on improving stress hyperglycemia（SHG）and insulin resistance（IR）in critically ill patients.
Methods
A total of 174 critically ill patients with SHG treated in our hospital from June 1，2018 to June 30，2019 were selected as the research objects，and they were divided into experimental group（89 cases）and control group（85 cases）according to random number table method.Patients in the experimental group used continuous nutrition pump infusion for EEN，and patients in the control group used intermittent nasal feeding with bolus injection.The blood glucose-related indicators（blood glucose at 4，8，12，16，20 h，blood glucose coefficient of variation [BGcv]，incidence of hyperglycemia），insulin resistance index（HOMA-IR）value，incidence of IR，fasting insulin（FINS），maximum tolerated calories，complete enteral nutrition ratio，intestinal tolerance，fasting blood glucose（FBG）at the seventh day after treatment and total insulin use within 7 days were compared in the two groups.The serum albumin（ALB）levels were recorded 2 days before treatment and the seventh day after treatment in the two groups.
Results
The levels of blood glucose at 4，8，12，16，20 h，BGcv，and incidence of hyperglycemia at the seventh day after nutritional treatment in the experimental group were lower than those in the control group，and the differences were statistically significant（
P
＜0.05）.The HOMA-IR value，incidence of IR，FINS at the seventh day after treatment，and total insulin use within 7 days of the experimental group were lower than those of the control group，and the differences were statistically significant（
P
＜0.05）.The maximum tolerated calories，complete enteral nutrition ratio，and intestinal tolerance of the experimental group were higher than those of the control group at the seventh day after treatment，and the differences were statistically significant（P＜0.05）.There was no significant difference in FBG level between the two groups at the seventh day after treatment（P＞0.05）.There were no significant differences in ALB levels between the two groups of patients at 2 days before treatment and the seventh day after treatment（P＞0.05）.
Conclusion
Compared with the bolus injection，the infusion of nutrition pump can better improve the state of SHG and IR after nutrition support treatment.It can cooperate with the regulation of blood glucose，reduce the incidence of hyperglycemia，provide sufficient energy support for the critically ill patients，and it can improve gastrointestinal tolerance，which has the significance of popularization in the practical work.
2020 Vol. 27 (4): 4-8转23 [
Abstract
] (
92
)
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9
Meta-analysis on effect and safety of Wenxin Granules combined with Metoprolol in the treatment of ischemic arrhythmia
LI Yu-zhen1 WU Wen-sheng2▲
[Abstract]
Objective
To systematically evaluate the effect and safety of Wenxin Granules combined with Metoprolol in the treatment of ischemic arrhythmia.
Methods
The literatures related to Wenxin Granules combined with Metoprolol in the treatment of ischemic arrhythmia published on China National Knowledge Infrastructure（CNKI），Wanfang Digital Periodical Full-text Database，Weipu Database，Chinese Biomedical Literature Service System，PubMed and Cochrane Library from the establishment of the database to June 2019 were searched.Cochrane evaluation method was used to evaluate literatures and Review Manager 5.3 was used for Meta-analysis.
Results
A total of 1752 patients with ischemic arrhythmia were included in 19 studies，including 877 cases in the treatment group and 875 cases in the control group.The total effective rate of the treatment group was higher than that of the control group，and the difference was statistically significant（RR=1.21，95%CI [1.17，1.26]，P＜0.000 01）.The incidence rate of adverse reactions in the treatment group was lower than that in the control group，and the difference was statistically significant（RR=0.41，95%CI [0.26，0.65]，P=0.0002）.
Conclusion
Wenxin Granules combined with Metoprolol has better effect in the treatment of ischemic arrhythmia，and it can reduce the incidence rate of adverse reactions and gain high safety.
2020 Vol. 27 (4): 9-13 [
Abstract
] (
78
)
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14
Meta-analysis of the correlation between high-density lipoprotein subfractions and the risk of cardio-cerebrovascular diseases
LI Qing-sheng WANG Jin-lan▲ ZHANG Jun-jun
[Abstract]
Objective
To systematically evaluate the correlation between high-density lipoprotein（HDL）subfractions and the risk of cardio-cerebrovascular diseases.
Methods
The literatures related to the relationship between HDL subfractions and cardio-cerebrovascular diseases published on PubMed，Embase，Cochrane Library，China National Knowledge Infrastructure（CNKI），Wanfang Database and Chinese Biomedical Literature Database（CBM）from the establishment of the database to July 2019 were searched.The inclusion and exclusion criteria were strictly followed.The stata 12.0 and Review Manager 5.3 software were used for Meta-analysis.
Results
HDL particle（HDLp）（RR=0.82，95%CI[0.77，0.87]，P＜0.000 01）and its subfractions defined by nuclear magnetic resonance were shown superior correlation with cardio-cerebrovascular disease to HDL cholesterol（HDL-C）（RR=0.93，95%CI [0.87，1.00]，P=0.05）.Within each individual ending events，HDL-C（RR=0.96，95%CI [0.91，1.01]，P=0.16），HDLp（RR=0.97，95%CI [0.82，1.15]，P=0.74）and its subfractions showed no correlation with the incidence of stroke.No correlation was observed between coronary artery disease and HDL2（RR=0.95，95%CI [0.87，1.04]，P=0.27）or HDL3（RR=0.89，95%CI [0.79，1.01]，P=0.06）defined by ultracentrifugation.
Conclusion
HDLp and its subfractions defined by nuclear magnetic resonance are better indicators for risk of coronary artery diseases than HDL-C.There are no associations between HDL-C，HDLp and HDLp subfractions and stroke.HDL subfractions defined by ultracentrifugation are not good predictors of the risk of coronary artery diseases.
2020 Vol. 27 (4): 14-18 [
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79
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19
Application status and research progress of enhanced recovery after surgery in laparoscopy liver resection
TIAN Tan-ping1 LUO Yong1,2▲ ZHOU Wei-hua1,3
[Abstract]
Enhanced recovery after surgery（ERAS）is an important direction of surgical development in the 21
st
century.It plays an important role in reducing patients stress and promoting rapid recovery of patients.Laparoscopic liver is an important direction for the development of liver surgery，and is an inevitable choice for the development ofminimally invasive surgery in the 21
st
century.However，laparoscopic hepatectomy has high technical requirements and relatively few postoperative complications.And its application in the ERAS concept，there are objective difficulties in the aspect，which limits the combination of laparoscopic liver resection and ERAS concept.How to apply the ERAS concept to laparoscopic liver resection is an urgent problem to be studied and solved，which is of great practical significance for promoting rapid recovery of patients and improving medical quality.
2020 Vol. 27 (4): 19-23 [
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] (
77
)
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24
Progress in applied research of massage with ointment therapy
Progress in applied research of massage with ointment therapy
[J]. 中国当代医药, 2020,27(4): 24-28')" href="#">
CHENG Hong-jie ZHANG Nai-wei LI Ting-ting ZHAO Bao-tuan AN Li-bao XU Shan-shan ZHANG Qiao-yan
[Abstract]
Massage with ointment therapy is the combine of massage and ointment，which has been used in department of internal，external，gynecological and pediatric.Based on the database of China National Knowledge Infrastructure，the author searched and analyzed the literatures，and found that there were the most literatures on the application of massage with ointment therapy in orthopedic diseases，among them，knee osteoarthritis was mainly studied.In the internal medicine disease，the massage with ointment therapy is mainly used for the functional disease.It is mostly for the disease that course is longer，poor therapeutic effect of the Western medicine，the side effect is big.However，there are few studies on the digestive system by massage with ointment therapy，especially，in the area of functional gastrointestinal disease，it is still a virgin land to be reclaimed.Therefore，it is necessary to carry out a randomized controlled trial to explore the therapeutic mechanism of massage with ointment therapy for functional gastrointestinal diseases.
2020 Vol. 27 (4): 24-28 [
Abstract
] (
78
)
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29
Progress in the research of neutrophil-lymphocyte ratio and red blood cell distribution width in evaluating the severity of acute pancreatitis
HUANG Bin HE Chi-yi▲
[Abstract]
Acute pancreatitis is a severe systemic inflammatory response，especially in severe acute pancreatitis.The course of the disease progresses rapidly and the mortality rate is high in some patients.Therefore，early identification of severe acute pancreatitis is of great significance.Currently，methods for evaluating the severity of acute pancreatitis such as acute physiology and chronic health evaluation（APACHE-Ⅱ）scoring system，Ranson scoring system，and modified Marshall score are complicated and difficult to operate.More and more studies have shown that neutrophil to lymphocyte ratio and red blood cell distribution width can be regarded as effective indexes to assess the severity of acute pancreatitis.This article reviews the progress in the research of neutrophil-lymphocyte ratio and red blood cell distribution width in evaluating the severity of acute pancreatitis.
2020 Vol. 27 (4): 29-31转35 [
Abstract
] (
79
)
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32
Effect of high volume hemofiltration therapy on inflammatory mediators in swine sepsis model
TU Yao-ran
[Abstract]
Objective
To study the effect of high volume hemofiltration on the inflammatory mediators in swine sepsis model.
Methods
A total of 15 Yorkshire healthy pigs were induced to replicate the swine sepsis model by intravenous Endotoxin.The models were randomly divided into three groups: control group，CVVH treatment group and HVHF treatment group，with 5 pigs in each group.The animals in the control group were not treated with hemofiltration，the CVVH group was treated with routine dose hemofiltration，and the HVHF group was treated with high volume hemofiltration.The changes of body temperature（T），heart rate（HR）and mean arterial pressure（MAP）in three groups of animals at different time of before endotoxin injection（T
0
），at the time of establishment of the model（T
1
）and at 2（T
2
），4（T
3
）and 6（T
4
）h were compared.The changes of interleukin-6（IL-6），interleukin-10（IL-10）and tumor necrosis factor-α（TNF-α）in the three groups at different time were compared.
Results
The T at T
3
and T
4
in CVVH group and HVHF group were lower than those in control group，and the HR was slower than that in control group，while MAP was higher than that in control group（P＜0.05）.The T at T
3
and T
4
in HVHF group were lower and HR was slower than that in the CVVH group，and MAP was higher than that in the CVVH group（P＜0.05）.The levels of IL-6，IL-10，and TNF-α at T
2
，T
3
and T
4
in CVVH group and HVHF group were lower than those in control group（P＜0.05），and the IL-6，IL-10 and TNF-α at T
3
and T
4
in HVHF group were lower than those in CVVH group（P＜0.05）.
Conclusion
High volume hemofiltration can effectively eliminate the excessive released inflammatory agents in the swine sepsis model，reduce the inflammatory response and improve the hemodynamic index.
2020 Vol. 27 (4): 32-35 [
Abstract
] (
83
)
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36
Predictive efficiency of quantitative detection of HBsAg on relapse of chronic hepatitis B patients with negative HBeAg treated with Entecavir
[Abstract]
Objective
To investigate the predictive efficiency of quantitative detection of Hepatitis B virus surface antigen（HBsAg）on the relapse of entecavir in patients with Hepatitis B virus antigen（HBeAg）negative chronic hepatitis B after discontinuation.
Methods
The clinical data of 83 outpatients with chronic hepatitis B treated with Entecavir from January 2016 to January 2017 were analyzed retrospectively，the patients were divided into relapse group（60 cases）and non relapse group（23 cases）according to the follow-up of 1 year，whether there was virological recurrence or not.The clinical data of relapse group and non relapse group were compared.The recurrence degree of HBsAg were compared in the relapse group at 6 and 12 months after drug withdrawal.Quantitative prediction of diagnostic efficacy of entecavir in relapsed group by HbsAg was analyzed.
Results
The baseline alanine aminotransferase（ALT），and HBsAg quantitative levels at the time of withdrawal were higher in the relapse group than those in the non-relapse group，the differences were statistically significant（P＜0.05）.There were no significant differences in gender，age，genotype，and incidence of cirrhosis and baseline Hepatitis B virus DNA（HBV DNA）between the two groups（P＞0.05）.The recurrence rate of different HBsAg quantitative levels in the relapse group at 12 months of discontinuation were higher than those at the 6 months of discontinuation，the difference was statistically significant（P＜0.05）.The area under the curve（AUC）for quantitative prediction of HBsAg discontinuation of entecavir withdrawal was 0.911（95%CI:0.828-0.962）.The optimal cutoff value for HBsAg quantification was 1.957 log
10
IU/ml，and the sensitivity and specificity were 85.00%and 98.00%，respectively.
Conclusion
Quantitative HBsAg level is more significant with the relapse time，and HBsAg quantitative detection has a higher diagnostic efficacy to predict relapse after entecavir discontinuation.
2020 Vol. 27 (4): 36-39 [
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] (
90
)
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43
Effect comparison of Azithromycin and Levofloxacin in the treatment of chronic bronchitis
LI Xiao-ming
[Abstract]
Objective
To study the effect of Azithromycin and Levofloxacin in the treatment of chronic bronchitis.
Methods
Eighty patients with chronic bronchitis treated in our hospital from February 2017 to August 2018 were selected and divided into control group and experimental group according to computer random method，with 40 cases in each group.The control group received Azithromycin treatment，and the experimental group received Levofloxacin treatment，the treatment effect and adverse reactions of patients of the two groups were compared.
Results
There were no significant differences in the total effective rate of treatment，the total incidence of complications，and the time to relieve of shortness of breath，cough，and dyspnea between the two groups（P＞0.05）.
Conclusion
Azithromycin and Levofloxacin both have good therapeutic effects in patients with chronic bronchitis.There is no significant difference in the therapeutic effect of the two drugs，and the incidence of adverse reactions is the same in both treatments.Therefore，in the subsequent clinical application，the medical staff can make rational selection and medication according to the specific conditions of the patient.
2020 Vol. 27 (4): 43-46 [
Abstract
] (
69
)
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47
Comparison of clinical effect between traditional thyroidectomy and ultrasound scalpel open thyroidectomy
LIU Cong
[Abstract]
Objective
To explore the clinical effect of traditional thyroidectomy and ultrasound scalpel open thyroidectomy.
Methods
The clinical data of 200 patients with thyroidectomy who were treated in our hospital from November 2017 to November 2018 were analyzed retrospectively.The patients were divided into control group（97 cases）and experimental group（103 cases）according to different surgical methods.The control group was given traditional thyroidectomy，and the experimental group was given ultrasound scalpel open thyroidectomy.The operation time，intraoperative blood loss，postoperative drainage，hospitalization time and the incidence of complications were compared between the two groups.
Results
The operation and hospitalization time of the experimental group were shorter than those of the control group，the amount of intraoperative blood loss and the amount of drainage after operation were less than those of the control group，the differences were statistical significance（P＜0.05）.There was no significant difference in the total incidence of complications between the two groups（P＞0.05）.
Conclusion
The use of ultrasonic scalpel open thyroid surgery can help patients shorten the operation and hospitalization time，while reducing the amount of intraoperative blood loss and postoperative drainage，which is superior to traditional thyroid surgery in all aspects and worthy of clinical promotion.
2020 Vol. 27 (4): 47-49 [
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] (
76
)
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50
Therapeutic effect of Thymosin Enteric-coated Tablets combined with Pegylated Interferon on patients with chronic hepatitis and its influences of related indexes
Therapeutic effect of Thymosin Enteric-coated Tablets combined with Pegylated Interferon on patients with chronic hepatitis and its influences of related indexes
[J]. 中国当代医药, 2020,27(4): 50-52')" href="#">
ZHANG Lian-feng YANG Li-min
[Abstract]
Objective
To investigate the effect of Thymosin Enteric-coated Tablets combined with Pegylated Interferon on serum CXC chemokine receptor 3（CXCR3），chemokine receptor 6（CCR6），interleukin 2（IL-2），liver function indicators and soluble ligand levels in patients with chronic hepatitis.
Methods
Seventy-four patients with chronic hepatitis who were admitted to our hospital from September 2017 to September 2018 were enrolled.They were divided into observation group（n=37）and control group（n=37）according to random number table method.In the control group，Thymosin Enteric-coated Tablets alone was used，while in the observation group，Thymosin Enteric-coated Tablets combined with Pegylated Interferon was adopted.The level of virological indicators of CXCR3，CCR6，albumin（ALB），total bilirubin（TBil），alanine aminotransferase（ALT），hepatitis B virus deoxyribonucleic acid（HBV-DNA），hepatitis B surface antigen（HBsAg），and E antigen of hepatitis B（HBeAg）after treatment were compared between the two groups.
Results
The CXCR3 and CCR6 levels in the observation group were higher than those in the control group，and the serum IL-2 level was lower than that in the control group; the ALB level in the observation group was higher than that in the control group; the levels of TBil，ALT，HBV-DNA，HBsAg and HBeAg were lower than those in the control group after treatment，the differences were statistically significant（P＜0.05）.
Conclusion
The levels of CXCR3，CCR6 and serum IL-2 in patients with chronic hepatitis treated with Thymosin Enteric-coated Tablets combined with Pegylated Interferon are effectively reduced，and the liver function and soluble ligand levels are markedly improved with a definite effect.
2020 Vol. 27 (4): 50-52 [
Abstract
] (
88
)
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53
Application effect of non-invasive ventilator assisted ventilation in adolescent obstructive sleep apnea hypopnea syndrome
Application effect of non-invasive ventilator assisted ventilation in adolescent obstructive sleep apnea hypopnea syndrome
[J]. 中国当代医药, 2020,27(4): 53-55')" href="#">
DENG Jie-fang HUANG Sui-hua DONG Jing-jun
[Abstract]
Objective
To explore the effect of non-invasive ventilator assisted ventilation in adolescent obstructive sleep apnea hypopnea syndrome（OSAHS）.
Methods
A total of 72 patients with adolescent OSAHS admitted to our hospital from September 2017 to September 2018 were enrolled in the study.They were divided into study group（36 cases）and control group（36 cases）according to the random number table method.The control group received routine treatment.The study group was treated with non-invasive ventilator assisted ventilation.The sleep monitoring，inflammatory factor levels，and sleep quality were compared between the two groups.
Results
There were no significant differences in oxygen index（ODI），respiratory disorder index（AHI），mean oxygen saturation（MSpO
2
），minimum oxygen saturation（LSpO
2
），serum C-reactive protein（CRP），and tumor necrosis factor-α（TNF-α），endothelin-1（ET-1）levels，and Pittsburgh sleep quality index（PSQI）scores before intervention（P＞0.05）.After intervention，the ODI，AHI，and TNF-α，ET-1，CRP levels and PSQI scores were lower than those before the intervention，MSpO
2
and LSpO
2
were higher than before the intervention in the two groups，and the ODI，AHI，TNF-α，ET-1，CRP levels and PSQI scores of the study group were lower than those of the control group，MSpO
2
and LSpO
2
were higher than those of the control group，and the differences were statistically significant（P＜0.05）.
Conclusion
Non-invasive ventilator assisted ventilation in the treatment of adolescent OSAHS can improve sleep monitoring data while reducing the body′s inflammatory response，so that patients have better sleep quality.
2020 Vol. 27 (4): 53-55 [
Abstract
] (
84
)
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56
Correlation analysis between autonomic nervous function and physical function in the elderly
Correlation analysis between autonomic nervous function and physical function in the elderly[J]. 中国当代医药, 2020,27(4): 56-58转75')" href="#">
LIU Ying-qi1 LIU Fei2▲ ZHANG Jing2▲
[Abstract]
Objective
To analyze the relationship between the autonomic nerve function and physical function in the elderly.
Methods
A total of 157 patients treated in the Department of Geriatric Medicine of Dalian Friendship Hospital from October 2017 to December 2018 were selected.The indicators of heart rate variability（HRV），physical function evaluation indicators（activities of daily living [ADL]scores）of patients were collected.According to the ADL scores，the patients were divided into self-care group（n=59），semi-self-care group（n=51）and non-self-care group（n=47）.The difference of HRV indicators in different physical function states and its correlation with ADL scores were analyzed.
Results
There were statically differences among the three groups in standard deviation of normal R-R intervals（SDNN），standard deviation of mean value of 5-minutesinus R-R interval（SDANN），triangular index，ultra-low frequency（ULF），very low frequency（VLF），low frequency/high frequency（LF/HF）（P＜0.05）.Pearson correlation analysis showed that SDNN，triangular index and LF/HF were positively correlated with ADL score（r=0.266，0.283，0.284; P＜0.05）.
Conclusion
HRV index can reflect the autonomic nervous function of the heart，which has a certain correlation with the physical function of the elderly.
2020 Vol. 27 (4): 56-58转75 [
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71
)
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59
Effect of Amiodarone in the treatment of arrhythmia and its influence on the level of hypersensitive C-reactive protein and heart rate variability in patients
Effect of Amiodarone in the treatment of arrhythmia and its influence on the level of hypersensitive C-reactive protein and heart rate variability in patients
[J]. 中国当代医药, 2020,27(4): 59-62')" href="#">
LUO Pei-liang
[Abstract]
Objective
To explore the effect of Amiodarone in the treatment of arrhythmia and its influence on the level of hypersensitive C-reactive protein and heart rate variability in patients.
Methods
The clinical data of 68 patients with arrhythmia admitted to our hospital from December 2013 to December 2018 were retrospectively analyzed.According to different treatment methods，they were divided into experimental group and control group，with 34 cases in each group.Patients in the control group were treated with Propafenone Hydrochloride，and patients in the experimental group were treated with Amiodarone Hydrochloride Tablets.The clinical efficacy，total incidence rate of adverse reactions and cardiac function indexes（heart rate and left ventricular ejection fraction），serum hypersensitive C-reactive protein level，and heart rate variability parameters（standard diviation of NN intervals [SDNN]，root mean square difference of RR interval [rMSSD]，standard diviation average of NN intervals [SDANN]，standard deviation of RR interval[RR-SDANN]）before and after treatment were compared between the two groups.
Results
The total effective rate of treatment in the experimental group was higher than that in the control group，and the difference was statistically significant（P＜0.05）.The heart rate and serum hypersensitive C-reactive protein level of the two groups after treatment were lower than those before treatment，and those in the experimental group were lower than those in the control group，with statistically significant differences（P＜0.05）.The left ventricular ejection fraction of the two groups of patients after treatment was higher than that before treatment，and that in the experimental group was higher than that in the control group，the difference was statistically significant（P＜0.05）.After treatment，SDNN，rMSSD，SDANN，and RR-SDANN in the two groups were higher than those before treatment，and those in the experimental group were higher than those in the control group，the differences were statistically significant（P＜0.05）.There was no significant difference in the total incidence rate of adverse reactions between the two groups of patients（P＞0.05）.
Conclusion
Amiodarone is more effective in the treatment of patients with arrhythmia，which can significantly enhance the cardiac function，reduce inflammation and increase the parameters of heart rate.
2020 Vol. 27 (4): 59-62 [
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] (
80
)
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63
Correlation of olfactory dysfunction with disease stage and dyskinesia of patients with Parkinson′s disease
Correlation of olfactory dysfunction with disease stage and dyskinesia of patients with Parkinson′s disease
[J]. 中国当代医药, 2020,27(4): 63-65')" href="#">
XU Yi-fan CHENG La-na
[Abstract]
Objective
To investigate the correlation of olfactory dysfunction with disease stage and dyskinesia of Parkinson′s disease.
Methods
A total of 50 patients with Parkinson′s disease in our hospital from August 2016 to August 2018 were randomly selected as the Parkinson′s disease group，and 50 health check-ups in our hospital during the same period were randomly selected as the healthy control group.The olfactory recognition threshold（IT）and olfactory perception threshold（DT）of the two groups were detected by five-scent olfaction test solution in a non-odor，ventilated and quiet environment.Then the DT and IT，5 odorants loss of smell in the two groups were analyzed statistically，the correlation between Parkinson′s disease score scale（UPDRS）score and olfactory function of patients with Parkinson′s disease were analyzed.
Results
The DT and IT of patients with stage 1，1.5，2，2.5 and 3 in the Parkinson′s disease group were higher than the healthy control group（P＜0.05）.The DT and IT of acid，banana，mint，flower fragrance and stench of the Parkinson′s disease group were higher than the healthy control group（P＜0.05）.There were no correlations between UPDRS score，motor function score，DT and IT of patients with Parkinson′s disease（P＞0.05）.The rates of acid，banana，mint，flower fragrance and odor loss of smell of the Parkinson′s disease group（12.0% [6/50]，34.0% [17/50]，46.0% [23/50]，34.0% [17/50]，52.0% [26/50]）were higher than the healthy control group（0.0% [0/50]，2.0% [1/50]，4.0% [2/50]，0.0% [0/50]，2.0% [1/50]）（P＜0.05）.
Conclusion
The degrees of olfactory dysfunction in Parkinson′s disease patients with different disease stages and dyskinesia are higher than healthy people，however，olfactory dysfunction in patients with Parkinson′s disease has no correlation with disease stage and dyskinesia.
2020 Vol. 27 (4): 63-65 [
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] (
82
)
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66
Clinical effect of Paroxetine in the treatment of Parkinson′s disease with depression
Clinical effect of Paroxetine in the treatment of Parkinson′s disease with depression
[J]. 中国当代医药, 2020,27(4): 66-68')" href="#">
Department of Psychiatry，Xiamen Xianyue Hospital，Fujian Province，Xiamen 361001，China
[Abstract]
Objective
To investigate the clinical effect of Paroxetine in the treatment of Parkinson′s disease with depression.
Mehods
Sixty patients with Parkinson′s disease accompanied by depression who were admitted to our hospital from January 2018 to January 2019 were selected as the research subjects，they were divided into observation group and control group according to the random number allocation principle，with 30 cases in each group.The control group was given routine treatment，and the observation group was treated with Paroxetine Tablets on the basis of the control group for 8 weeks.The unified Parkinson′s disease rating scale（UPDRS）and Hamilton depression scale（HAMD）scores were compared before and after treatment.
Results
The UPDRS score of the observation group was lower than that of the control group 8 weeks after treatment，the difference was statistically significant（P＜0.05）.The HAMD score of the observation group was lower than that of the control group at 4 and 8 weeks after treatment，the differences were statistically significant（P＜0.05）.
Conclusion
The application of Paroxetine in the treatment of Parkinson′s disease with depression can alleviate the symptoms and depression of patients，which is worthy of clinical application.
2020 Vol. 27 (4): 66-68 [
Abstract
] (
87
)
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69
Analysis on independent risk factors for stroke in young adults
Analysis on independent risk factors for stroke in young adults
[J]. 中国当代医药, 2020,27(4): 69-71')" href="#">
WANG Ye XU Mei-chen LIU Mei-jie
[Abstract]
Objective
To analyze the independent risk factors influencing stroke in young adults.
Methods
A total of 60 young adult patients with stroke who were treated in Liaoning Provincial People′s Hospital during the period from January 2016 to January 2018 were enrolled in stroke group.A total of 60 healthy young adults who underwent physical examination in the same period in Liaoning Provincial People′s Hospital were enrolled as healthy group.The differences in gender，drinking，diabetes mellitus，long-acting contraceptives，vertebral artery dissection and patent foramen ovale（PFO）were compared between stroke group and healthy group.Logistic regression equation was performed to analyze the independent risk factors influencing stroke in young adults.
Results
The proportions of patients with drinking not less than 30 g/d，hypertension，frequency of long-acting contraceptives not less than 3 times/year，vertebral artery dissection and PFO in stroke group were higher than those in healthy group，the differences were statistically significant（P＜0.05）.Logistic regression analysis showed that amount of alcohol not less than 30 g/d（β=0.227，OR=1.255，95%CI=1.129-1.395），hypertension（β=0.139，OR=1.149，95%CI=1.069-1.236），diabetes mellitus（β=0.284，OR=1.328，95%CI=1.200-1.471），use frequency of long-acting contraceptives not less than 3 times/year（β=0.276，OR=1.318，95%CI=1.223-1.420），vertebral artery dissection（β=0.262，OR=1.300，95%CI=1.211-1.395）and PFO（β=0.271，OR=1.311，95%CI=1.215-1.415）were all independent risk factors influencing stroke in young adults（P＜0.05）.
Conclusion
Drinking，hypertension，diabetes mellitus，use frequency of long-acting contraceptives，vertebral artery dissection and PFO are all risk factors influencing stroke in young adults.
2020 Vol. 27 (4): 69-71 [
Abstract
] (
89
)
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72
Effect of Zhengqing Fengtongning oriented permeation on early type 2 diabetic nephropathy
Effect of Zhengqing Fengtongning oriented permeation on early type 2 diabetic nephropathy
[J]. 中国当代医药, 2020,27(4): 72-75')" href="#">
WANG Na WANG Ying LIU Xian-jiang HU Jian-zhuo▲
[Abstract]
Objective
To explore the effect of Zhengqing Fengtongning oriented permeation on early type 2 diabetic nephropathy.
Methods
From April 2018 to March 2019，60 patients with early type 2 diabetic nephropathy admitted to the nephrotic endocrinology department of our hospital were selected as research objects，and randomly divided into control group（30 cases）and treatment group（30 cases）according to the treatment sequence.Patients in the control group were given basic treatment for diabetic nephropathy，while patients in the treatment group were treated with Zhengqing Fengtongning oriented permeation therapy on the basis of the control group for 4 weeks.The urinary albumin excretion rate（UAER），24h urine protein quantification，urinary β
2
microglobulin（β
2
-MG），serum albumin（ALB），prealbumin（PA），glycosylated hemoglobin（HbA1c）levels before and after treatment were compared between the two groups，and the total effective rate and adverse reactions of the two groups were compared.
Results
The UAER，24h urine protein，β
2
-MG，HbA1c levels of the two groups after treatment were lower than before treatment，ALB，PA were higher than before treatment，the differences were statistically significant（P＜0.05）.After treatment，UAER，24h urine protein and β
2
-MG of patients in the treatment group were lower than those in the control group，ALB and PA were higher than those in the control group，the differences were statistically significant（P＜0.05）.There was no significant difference in HbA1c between the two groups after treatment（P＞0.05）.The total effective rate of the treatment group was higher than that of the control group，and the difference was statistically significant（P＜0.05）.One case of mild rash occurred in the control group，and the experiment was continued after anti-allergy and antipruritic treatment.No obvious adverse reactions were found in the observation group.
Conclusion
Zhengqing Fengtongning oriented permeation has the effects of obviously reducing urine protein content of early type 2 diabetic nephropathy patients，improving renal tubular function，improving nutritional indicators of patients，etc.，and is worthy of clinical application and promotion.
2020 Vol. 27 (4): 72-75 [
Abstract
] (
90
)
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76
Clinical effect ofminimally invasive percutaneous nephrolithotomy in the treatment of renal calculi
Clinical effect ofminimally invasive percutaneous nephrolithotomy in the treatment of renal calculi
[J]. 中国当代医药, 2020,27(4): 76-78转82')" href="#">
CHEN Wen-cheng CHEN Zhi-xiong▲ SU Xue-yong LIANG Shi-min DONG Guang-hua ZHANG Sai
[Abstract]
Objective
To investigate the clinical effect ofminimally invasive percutaneous nephrolithotomy（mPCNL）in the treatment of renal calculi.
Methods
A total of 106 patients with renal calculi admitted to our hospital from March 2018 to February 2019 were selected as research objects，and were divided into observation group and control group by random number table method，53 cases in each group.Patients in the observation group were treated with mPCNL，while patients in the control group were treated with standard channel percutaneous nephrolithotomy（SPCNL）.The disposable stone clearance rate，perioperative related indexes，pain，renal function indexes（β
2
-microglobulin [β
2
-MG]，urea nitrogen [BUN]，serum creatinine [Cr]）and complications were compared between the two groups.
Results
The intraoperative blood loss in the observation group（[107.63±22.19]ml）was less than that in the control group（[153.41±26.38]ml），the hospitalization time（[8.36±1.29]d）wass shorter than that in the control group（[12.36±1.87]d），and the visual analogue scale（VAS）score（[2.42±0.68]points）was lower than that in the control group（[3.36±0.79]points），the operation time（[129.64±20.53]min）was longer than that of the control group（[102.41±18.76]min），with statistically significant differences（P＜0.05）.Before operation，there were no significant difference in β
2
-MG，BUN and Cr levels between the two groups（P＞0.05）.After operation，the β
2
-MG（[2.13±0.80]ng/L），BUN（[8.37±2.13]mmol/L），Cr（[92.53±9.57]mmol/L）levels in the observation group were lower than those in the control group（[3.45±0.87]ng/L，[14.51±2.24]mmol/L，[106.92±10.43]mmol/L），the differences were statistically significants（P＜0.05）.The total incidence of complications in the observation group（3.77%）was lower than that in the control group（15.09%），and the difference was statistically significant（P＞0.05）.The removal rate of one-off stones in the observation group（90.57%）was not significantly different from that in the control group（86.79%）（P＞0.05）.
Conclusion
MPCNL has the advantages of less trauma，high stone clearance rate and fewer complications in the treatment of renal calculi，it can reduce postoperative pain，shorten hospitalization time，reduce renal damage and has clinical application and popularization value.
2020 Vol. 27 (4): 76-78转82 [
Abstract
] (
106
)
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14
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79
Analysis of risk factors for systemic inflammatory response syndrome after percutaneous nephrolithotomy
Analysis of risk factors for systemic inflammatory response syndrome after percutaneous nephrolithotomy
[J]. 中国当代医药, 2020,27(4): 79-82')" href="#">
HUANG Yao-lin PAN Lian-chun CAI Yi-chuan CHEN Chu-huai ZHAN Zhen-sheng LI Ying-dong
2020 Vol. 27 (4): 79-82 [
Abstract
] (
68
)
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11
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83
Risk factors analysis of bleeding after endoscopic polypectomy of colon
Risk factors analysis of bleeding after endoscopic polypectomy of colon
[J]. 中国当代医药, 2020,27(4): 83-85')" href="#">
YANG Jin-lu
[Abstract]
Objective
To explore the risk factors of bleeding after endoscopic polypectomy of colon.
Methods
A total of 126 patients with colon polyps underwent endoscopic polypectomy in Chaisang District People′s Hospital of Jiujiang City from January 2017 to June 2019 were selected as the subjects.According to whether hemorrhage occurs，the patients were divided into case group（hemorrhage group）8 cases and control group（no hemorrhage group）118 cases.The clinical data of two groups were compared，and the risk factors of postoperative bleeding were analyzed.
Results
Of 126 patients，8 cases had hemorrhage，and the complication rate was 6.35%.Univariate analysis showed that there were significant differences in diabetes mellitus，hyperlipidemia，family history，smoking history，body mass index（BMI），postoperative eating time，polyp size，polyp morphology and polyp number between the two groups（P＜0.05）.Multivariate Logistic regression analysis showed that diabetes（β=2.407，OR=1.846，95%CI 1.135-2.473），hyperlipidemia（β=2.561，OR=2.843，95%CI 1.153-3.746），postoperative feeding time ＜24h（β=3.427，OR=2.486，95%CI 1.736-3.418），polyps with no pedicled polyps（β=1.168，OR=1.572，95%CI 0.745-1.948）were independent risk factors for bleeding after polypectomy（P＜0.05）.
Conclusion
Patients with diabetes mellitus，hyperlipidemia，food intake less than 24hours after operation，polyp form as pediceless polyp，and the risk of bleeding after colon polyp resection under endoscope increased.The risk factors mentioned above should be fully considered and taken into account during operation，and effective measures should be taken in advance to reduce the risk of bleeding.
2020 Vol. 27 (4): 83-85 [
Abstract
] (
96
)
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13
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86
Application effect of laparoscope combined with choledochoscope common bile duct lithotomy on intrahepatic and extrahepatic bile duct stones
Application effect of laparoscope combined with choledochoscope common bile duct lithotomy on intrahepatic and extrahepatic bile duct stones
[J]. 中国当代医药, 2020,27(4): 86-88转92')" href="#">
PAN Wen-jun
[Abstract]
Objective
To explore application effect of laparoscope combined with choledochoscope common bile duct lithotomy on intrahepatic and extrahepatic bile duct stones.
Methods
The clinical data of 60 patients with intrahepatic and extrahepatic bile duct stones admitted to the Department of General Surgery of Liaoyang Central Hospital from January 2014 to December 2018 were retrospectively analyzed.They were divided into control group（31 cases）and study group（29 cases）according to different surgical plans.The control group was treated with traditional laparotomy，while study group was treated with laparoscope combined with choledochoscope common bile duct lithotomy.The operation time，total intraoperative blood loss，postoperative anal exhaust time and total hospitalization time were compared between the two groups.The visual analogue scale（VAS）score was performed to evaluate pain degree in both groups at 12，24，48 and 72 h after surgery.The total incidence of postoperative complications in both groups was statistically analyzed.
Results
The operation time，postoperative anal exhaust time and total hospitalization time in study group were shorter than those in control group，the differences were statistically significant（P＜0.05），and total intraoperative blood loss was lower than that in control group，the difference was statistically significant（P＜0.05）.At 12，24，48，72 h after surgery，the VAS scores in study group were lower than those in control group，the differences were statistically significant（P＜0.05）.The VAS scores of the two groups at 48 and 72 h after surgery were lower than that at 12 h after surgery，with statistically significant differences（P＜0.05）.The total incidence of complications in the study group was 10.34%，compared with 22.58% in the control group，the difference was not statistically significant（P＞0.05）.
Conclusion
Laparoscope combined with choledochoscope common bile duct lithotomy in treatment of intrahepatic and extrahepatic bile duct stones can significantly shorten operation time，postoperative anal exhaust time and total hospitalization time，the blood loss is little，and pain is weaker，it is worthy of clinical application
2020 Vol. 27 (4): 86-88转92 [
Abstract
] (
70
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89
Application effect of laparoscopicminimally invasive surgery in patients with appendicitis
Application effect of laparoscopicminimally invasive surgery in patients with appendicitis
[J]. 中国当代医药, 2020,27(4): 89-92')" href="#">
LIU Peng
[Abstract]
Objective
To investigate the application effect of laparoscopicminimally invasive surgery in patients with appendicitis.
Methods
Seventy patients with acute appendicitis admitted to our hospital from March 2016 to March 2019 were selected as the research subjects，they were divided into the control group（n=35）and the observation group（n=35）according to the random number table method.The control group used open appendectomy，and the observation group used laparoscopic appendectomy.The anus exhaust time，bedtime activity time，hospital stay，inflammatory factor levels before and after surgery，and clinical treatment were compared between the two groups.
Results
The anal exhaust time，bedtime activity and hospital stay of the observation group were shorter than those of the control group，the differences were statistically significant（P＜0.05）.The incidence of wound infection in the observation group was lower than that in the control group，the difference was statistically significant（P＜0.05）.The levels of interleukin-6（IL-6），C-reactive protein（CRP）and tumor necrosis factor-α（TNF-α）in the observation group were lower than those in the control group at 1 day after operation，the differences were statistically significant（P＜0.05）.The total effective rate of treatment in the observation group was 100.00%，which was higher than 85.71% in the control group，the difference was statistically significant（P＜0.05）.
Conclusion
Laparoscopicminimally invasive surgery can shorten the patients′ anal exhaust time，bedtime and hospitalization time，reduce the incidence of postoperative wound infection and the expression of inflammatory factors，and improve the treatment effect.It is worthy of clinical promotion and application.
2020 Vol. 27 (4): 89-92 [
Abstract
] (
83
)
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93
Application of double-lumen tracheal tube intubation guided by Discopo in the mediastinal tumor resection
Application of double-lumen tracheal tube intubation guided by Discopo in the mediastinal tumor resection
[J]. 中国当代医药, 2020,27(4): 93-95转99')" href="#">
YUAN Lei ZENG Jian-qiang HUANG Jin-hua
[Abstract]
Objective
To observe the application clinical effect of double-lumen tracheal tube intubation guided by Discopo in the mediastinal tumor resection.
Methods
Thirty patients with mediastinal tumor resection in our hospital from January 2017 to December 2018 were selected as the research subjects，and they were divided into the Discopo group（group D）and the GlideScope video laryngoscope group（group G）according to the random number table method，15 cases in each group.The patients in group D were guided by Discopo for intubation，and the patients in group G were assisted by video laryngoscope.The intubation time，the success rate of one intubation，the positioning time，and the hemodynamic indicators（mean arterial pressure [MAP]，heart rate [HR]）before anesthesia induction（T
1
），after anesthesia induction（T
2
），immediate successful intubation（T
3
），and 5minutes after intubation（T
4
）were compared between the two groups.
Results
There were no significant differences in MAP and HR at T
1
and T
2
between the two groups（P＞0.05）.The MAP and HR in the two groups at T
2
，T
3
，and T
4
were lower than those at T
1
，and the differences were statistically significant（P＜0.05）.The MAP and HR at T
3
and T
4
in group D were lower than those in group G，and the differences were statistically significant（P＜0.05）.There was no significant difference in the success rate of one intubation between the two groups of patients（P＞0.05）.The intubation time and positioning time were shorter in group D than those in group G，and the differences were statistically significant（P＜0.05）.
Conclusion
The intubation time of doublelumen tracheal tube intubation guided by Discopo is short，and the impact on the cardiovascular system of patients is small when intubating.
2020 Vol. 27 (4): 93-95转99 [
Abstract
] (
69
)
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96
Clinical effect of Recombinant Human Granulocyte Stimulating Factor combined with VDLP regimen in the treatment of patients with Philadelphia chromosome-negative acute lymphoblastic leukemia
Clinical effect of Recombinant Human Granulocyte Stimulating Factor combined with VDLP regimen in the treatment of patients with Philadelphia chromosome-negative acute lymphoblastic leukemia[J]. 中国当代医药, 2020,27(4): 96-99')" href="#">
SI Yan-hui1 WANG Yang-yang1 LI Bing1 HUANG Peng-cheng1 LI Lu-ke2
[Abstract]
Objective
To study the clinical effect of Recombinant Human Granulocyte Stimulating Factor combined with VDLP regimen in the treatment of patients with Philadelphia chromosome-negative acute lymphoblastic leukemia（ALL）.
Methods
A total of 60 patients with Philadelphia chromosome-negative ALL admitted to the the First People′s Hospital of Zhaoqing and General Hospital of Pingmei Shenma Medical Group from March 2014 to March 2018 were selected as the study subjects，and they were divided into the control group and the study group according to the random number table method，30 cases in each group.The control group was treated with VDLP regimen，and the study group was treated with Recombinant Human Granulocyte Stimulating Factor on the basis of the control group.The therapeutic effect，the absolute reduction time of white blood cells and neutrophils，the total incidence rate of adverse reactions and quality of life（GQOLI-74）score before and after treatment were compared between the two groups.
Results
The total remission rate in the study group（70.00% [21/30]）was higher than that in the control group（43.33% [13/30]），and the difference was statistically significant（P＜0.05）.The absolute reduction time of white blood cells and neutrophils in the study group was shorter than that in the control group，and the difference was statistically significant（P＜0.05）.The total incidence rate of adverse reactions in the study group（6.67% [2/30]）was lower than that in the control group（26.67% [8/30]），and the difference was statistically significant（P＜0.05）.After treatment，the psychological function，physical function，material life，and social function scores of the two groups were higher than those before treatment，and those in the study group were higher than those in the control group，with statistically significant differences（P＜0.05）.
Conclusion
Recombinant Human Granulocyte Stimulating Factor combined with VDLP regimen in the treatment of patients with Philadelphia chromosome-negative ALL can effectively improve the therapeutic effect，shorten the absolute reduction time of white blood cells and neutrophils，reduce the incidence rate of adverse reactions and improve the prognosis of patients.
2020 Vol. 27 (4): 96-99 [
Abstract
] (
70
)
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100
Clinical effect comparison of combined thoracic and laparoscopic surgery and conventional thoracotomy in the treatment of esophageal cancer
Clinical effect comparison of combined thoracic and laparoscopic surgery and conventional thoracotomy in the treatment of esophageal cancer
[J]. 中国当代医药, 2020,27(4): 100-102转106')" href="#">
LIANG Lei WANG Ze-xue
[Abstract]
Objective
To explore the clinical effect of combined thoracic and laparoscopic surgery and conventional thoracotomy in the treatment of esophageal cancer.
Methods
A total of 200 patients with esophageal cancer treated in our hospital from July 2014 to April 2019 were selected as the research objects.They were divided into control group（100 cases）and observation group（100 cases）according to the random number table method.The patients in the control group were operated by conventional thoracotomy，while the patients in the observation group were operated by thoracoscopy combined with laparoscopy.The operative time，intraoperative blood loss，number of lymph node dissection，thoracic drainage，postoperative extubation time，hospitalization time，pulmonary function indicators and complications of the two groups were compared.
Results
There was no statistically significant difference in operative time and intraoperative blood loss between the two groups（P＞0.05）.The number of lymph node dissection in the observation group was more than that in the control group，and the difference was statistically significant（P＜0.05）.The thoracic drainage volume in the observation group was less than that in the control group，and the difference was statistically significant（P＜0.05）.The time of extubation and hospitalization in the observation group were shorter than those in the control group，with statistically significant differences（P＜0.05）.The vital capacity（VC），maximal voluntary ventilation（MVV）and forced expiratory volume in one second（FEV
1
）in the observation group were higher than those in the control group，with statistically significant differences（P＜0.05）.The total incidence of complications in the observation group was lower than that in the control group，and the difference was statistically significant（P＜0.05）.
Conclusion
The clinical effect of thoracic and laparoscopic surgery has an significant effect on patients with esophageal cancer，with ideal completion of surgery，which can recover lung function，and has less postoperative complications，it is worthy of clinical application.
2020 Vol. 27 (4): 100-102转106 [
Abstract
] (
71
)
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15
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103
Effect of immediate repair of breast defect with adjacent flap transfer in breast conserving surgery of upper quadrant breast cancer and its influence on the life quality of patients
Effect of immediate repair of breast defect with adjacent flap transfer in breast conserving surgery of upper quadrant breast cancer and its influence on the life quality of patients
[J]. 中国当代医药, 2020,27(4): 103-106')" href="#">
HUANG Ren-feng OU Lin-yang WU Wan-ming
[Abstract]
Objective
To evaluate the effect of immediate repair of breast defects by adjacent flap transfer during breast conserving surgery and quality of life in patients with inner upper quadrant breast cancer.
Methods
A total of 100 cases of patients with inner upper quadrant breast cancer treated in our hospital were selected as the subjects，and divided into control group and observation group according to random number table method，with 50 cases in each group.The patients in the control group were treated with modified radical mastectomy.The patients in the observation group received immediate repair of breast defects by adjacent flap transfer during breast conserving surgery.The surgical status，cosmetic effect，quality of life，the total treatment satisfaction and total incidence of adverse events of the two groups were compared.
Results
There was no significant difference in operation time，intraoperative blood loss and hospitalization time between the two groups（P＞0.05）.The good rate of cosmetic effect，physiological function and mental health scores in the observation group were higher than those in the control group，the differences were statistically significant（P＜0.05）.The total treatment satisfaction in the observation group was higher than that in the control group，and the difference was statistically significant（P＜0.05）.There was no significant difference in the total incidence of adverse events between the two groups（P＞0.05）.
Conclusion
For female breast cancer patients，the immediate repair of breast defects by adjacent flap transfer during breast conserving surgery can significantly improve the mental health and physiological function，maintain the beauty of the breast，enhance the satisfaction of treatment.And it has no significant impact on the operation and postoperative adverse events，which is worthy of further promotion in clinical practice.
2020 Vol. 27 (4): 103-106 [
Abstract
] (
72
)
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9
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107
Clinical effect of Milrinone in the treatment of congenital heart disease complicated with severe pneumonia and heart failure in children
Clinical effect of Milrinone in the treatment of congenital heart disease complicated with severe pneumonia and heart failure in children
[J]. 中国当代医药, 2020,27(4): 107-109转114')" href="#">
WANG Xiao-wei1 LIU Jiang-ping2 ZOU Yong1
2020 Vol. 27 (4): 107-109转114 [
Abstract
] (
65
)
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110
A study on the correlation between temperament assessment and attention deficit hyperactivity disorde in children
A study on the correlation between temperament assessment and attention deficit hyperactivity disorde in children
[J]. 中国当代医药, 2020,27(4): 110-114')" href="#">
YAN Juan-feng CHEN Lei WU Hong-ling YANG Hong-ping
2020 Vol. 27 (4): 110-114 [
Abstract
] (
65
)
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6
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115
Application effect of fiberoptic bronchoscope in children aged 0-6 years old with plastic bronchitis
Application effect of fiberoptic bronchoscope in children aged 0-6 years old with plastic bronchitis
[J]. 中国当代医药, 2020,27(4): 115-117')" href="#">
HUANG Zhi-rong
[Abstract]
Objective
To explore the application effect of fiberoptic bronchoscope in children 0-6 years old with plastic bronchitis.
Methods
The clinical data of 120 pediatric children with plastic bronchitis treated in our hospital from January 2018 to July 2019 were retrospectively analyzed.They were divided into the control group（n=60）and the observation group（n=60）according to different treatment methods.In the control group，pulmonary computed tomography and histopathological sectionon foreign matter in the bronchial cavity and conservative treatment were used.In the observation group，fiberoptic bronchoscopy was ued for diagnosis and treatment.The oxygenation index after treatmentand treatment effect of the two groups were compared.
Results
The oxygenation index of the observation group was（456.93±19.98）mmHg after treatment，which was higher than that of the control group of（322.59±25.67）mmHg，and the difference was statistically significant（P＜0.05）.The treatment effect of the observation group was better than that of the control group，with a statistical difference（P＜0.05）.
Conclusion
The application of fiberoptic bronchoscope in the clinical treatment of 0-6 years old children with plastic bronchitis improves the oxygenation index and the treatment effect is significant，which deserves widespread clinical promotion.
2020 Vol. 27 (4): 115-117 [
Abstract
] (
74
)
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118
Clinical effect of individualized calcium supplementation combined with Vitamin D in the treatment of children with retarded psychomotor development
Clinical effect of individualized calcium supplementation combined with Vitamin D in the treatment of children with retarded psychomotor development
[J]. 中国当代医药, 2020,27(4): 118-120')" href="#">
CHEN Kui-huan
[Abstract]
Objective
To explore the clinical effect of individualized calcium supplementation combined with Vitamin D in the treatment of children with retarded psychomotor development.
Methods
A total of 200 children with gross motor retardation admitted to our children′s health clinic from February to December 2018 were selected by Peabody motor development scale as the study objects，they were divided into the experimental group（104 cases）and the control group（96 cases）according to the random sampling method.The control group was treated with routine massage，while the experimental group was treated with individualized calcium supplement and Vitamin D on the basis of the control group（supplement according to the dietary structure and actual intake calculation difference of children）.The childrens′ gross motor development quotient（GMQ）was measured after 1 and 2 months of treatment，and the motor function recovery rate was compared between the two groups.The motor development index（PDI）after 2 months was compared between the two groups.
Results
The motor function recovery rate of children in the experimental group after treatment for 1 and 2 months were higher than those in the control group，the differences were statistically significant（P＜0.05）.The PDI in the experimental group was higher than that in the control group，the difference was statistically significant（P＜0.05）.
Conclusion
Individualized application of calcium combined with Vitamin D treatment can improve the early recovery rate and motor development of children with motor retardation，which is worthy of clinical application.
2020 Vol. 27 (4): 118-120 [
Abstract
] (
67
)
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121
Clinical effect of Vitamin D combined with Drospirone Ethinylestradiol Tablets in the treatment of polycystic ovary syndrome
Clinical effect of Vitamin D combined with Drospirone Ethinylestradiol Tablets in the treatment of polycystic ovary syndrome
[J]. 中国当代医药, 2020,27(4): 121-123转126')" href="#">
LIU Ting CAI Yu-feng ZENG Xiao-zhen
[Abstract]
Objective
To explore the clinical effect of Vitamin D combined with Drospirone Ethinylestradiol Tablets in the treatment of polycystic ovary syndrome（PCOS）.
Methods
A total of 98 patients with PCOS admitted in our hospital from October 2017 to October 2018 were selected and randomly divided into control group and research group，49 cases in each group.The control group was treated with Drospirone Ethinylestradiol Tablets，while the research group was treated with Vitamin D on the basis of the control group.The hormone levels and glucose and lipid metabolism indexes before and after treatment were compared between the two groups，and the therapeutic effects of the two groups were compared.
Results
The levels of serum luteinizing hormone（LH），testosterone（T），low density lipoprotein cholesterol（LDL-C）and fasting insulin in the two groups after treatment were lower than those before treatment，and the differences were statistically significant（P＜0.05）.The levels of serum follicle-forming hormone（FSH）in the two groups after treatment were higher than those before treatment，and the differences were statistically significant（P＜0.05）.The levels of serum LH，T，LDL-C and fasting insulin in the research group were higher than those in the control group after treatment，and the differences were statistically significant（P＜0.05）.The level of serum FSH in the research group was lower than that in the control group after treatment，and the difference was statistically significant（P＜0.05）.The treatment efficiency rate of the research group was higher than that of the control group，and the difference was statistically significant（P＜0.05）.
Conclusion
Vitamin D combined with Drospirone Ethinylestradiol Tablets in the treatment of PCOS patients is more conducive to the improvement of hormone levels，the improvement of glucose and lipid metabolism，and the improvement of therapeutic effect.
2020 Vol. 27 (4): 121-123转126 [
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] (
98
)
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124
Changes and clinical significance of four blood coagulation indexes in pregnant women during different gestational periods
Changes and clinical significance of four blood coagulation indexes in pregnant women during different gestational periods
[J]. 中国当代医药, 2020,27(4): 124-126')" href="#">
HE Huan-qun LIANG Shan-ying ZHAO Zheng-yun DENG Yu-ying LIU Li-yan
2020 Vol. 27 (4): 124-126 [
Abstract
] (
113
)
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127
Effect of forceps delivery on maternal and child outcomes under the new standard of labor process
Effect of forceps delivery on maternal and child outcomes under the new standard of labor process
[J]. 中国当代医药, 2020,27(4): 127-129')" href="#">
YAO Qing-lan
[Abstract]
Objective
To explore the effect of new standard forceps production assisted delivery on maternal and child outcomes.
Methods
Eighty women with maternal delivery assisted by the second stage of labor in our hospital from March 2017 to March 2019 were selected as the research subjects.They were divided into observation groups（40 cases）and the reference group（40 cases）.The old standard obstetric forceps were used in the reference group，in the observation group，the new standard obstetric forceps was used.Transit cesarean section rate，incidence of postpartum complication and neonatal adverse outcomes and Apgar score between two groups were compared.
Results
The rate of cesarean section in the observation group was higher than that in the reference group，the difference was statistically significant（P＜0.05）.Total incidence of postpartum complications and neonatal adverse events（intrauterine asphyxia，pneumonia，hypoxic ischemic encephalopathy，etc.），1min Apgar score of newborn，showed no statistically significant differences in the two groups（P＞0.05）.
Conclusion
After the new standard of labor process，the production of forceps will not increase the adverse outcome of the mother and child，but may increase the rate of cesarean section.
2020 Vol. 27 (4): 127-129 [
Abstract
] (
55
)
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130
Clinical effect of laparoscopic resection and repair in the treatment of uterine scar pregnancy after Ⅱ-Ⅲcesarean section with menopause ＜7 weeks
Clinical effect of laparoscopic resection and repair in the treatment of uterine scar pregnancy after Ⅱ-Ⅲcesarean section with menopause ＜7 weeks
[J]. 中国当代医药, 2020,27(4): 130-132')" href="#">
HU Ting PENG Ling LYU Dong-xia
[Abstract]
Objective
To investigate the clinical effect of laparoscopic resection and repair in the treatment of cesarean car pregnancy（CSP）after Ⅱ-Ⅲcesarean section with menopause ＜7 weeks.
Methods
Sixty-three patients with CSP after type Ⅱ-Ⅲcesarean section who were admitted to our hospital from April 2017 to February 2019 were enrolled in the study.They were divided into observation groups（31 cases）and the control group（32 cases）according to different treatment methods.The observation group was treated with laparoscopic lesion removal and repair，and the control group was treated with hysteroscopic lesion removal.The hospital stay，time of normal menstruation after operation，the success rate of surgery，the satisfaction rate of surgical treatment，and the total incidence of surgical complications were compared between two groups.
Results
The hospital stays and time of normal menstruation after operation in the observation group were shorter than those in the control group，the differences were statistically significant（P＜0.05）.The total success rate of the observation group was higher than that of the control group，the difference was statistically significant（P＜0.05）.The total satisfaction of surgical treatment was higher than that of the control group，and the difference was statistically significant（P＜0.05）.The total incidence of surgical complications in the observation group was lower than that of the control group，and the difference was statistically significant（P＜0.05）.
Conclusion
Laparoscopic lesion removal and repair is safer than hysteroscopy in the treatment of CSP after cesarean section of type Ⅱ-Ⅲwhose menopausal time is less than 7 weeks.The success rate of operation is higher，which can promote the recovery after operation，shorten the hospitalization time and promote the recovery of normal menstruation after operation.It has important therapeutic value.
2020 Vol. 27 (4): 130-132 [
Abstract
] (
81
)
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133
Clinical effect of simple nasal continuous positive airway pressure oxygen therapy on neonatal respiratory distress syndrome
Clinical effect of simple nasal continuous positive airway pressure oxygen therapy on neonatal respiratory distress syndrome
[J]. 中国当代医药, 2020,27(4): 133-135')" href="#">
LU Yu-ren HAN Dong-mei
[Abstract]
Objective
To investigate the clinical efficacy and safety of simple nasal obstructive continuous positive airway pressure oxygen（CPAP）therapy for neonatal respiratory distress syndrome（RDS）.
Methods
A total of 40 children with RDS treated in our hospital from October 2015 to October 2017 were selected and divided into observation group and control group by random number table method，20 cases in each group.The control group was treated with pulmonary surfactant; the observation group was treated with CPAP，and the clinical efficacy and safety were analyzed.
Results
There were no significant difference in arterial partial pressure of oxygen（PaO
2
），arterial partial pressure of carbon dioxide（PaCO
2
）and oxygen saturation（SaO
2
）between the two groups before treatment（P＞0.05）.After treatment，PaO
2
，PaCO
2
and SaO
2
of the two groups were significantly improved（P＜0.05）.After treatment，the PaO
2
and SaO
2
indexes of the observation group were higher than those of the control group，and the PaCO
2
indexes was lower than that of the control group，the differences were statistically significant（P＜0.05）.The rate of intraventricular hemorrhage and mortality in the observation group were lower than those in the control group，and the treatment time of positive pressure breathing was shorter than that in the control group，the differences were statistically significant（P＜0.05）.
Conclusion
CPAP can effectively improve the clinical symptoms of RDS in children，and it is safe and reliable，which is worthy of clinical application.
2020 Vol. 27 (4): 133-135 [
Abstract
] (
67
)
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136
Application effect of Deoxyprogesterone Estradiol Tablets after induced abortion
Application effect of Deoxyprogesterone Estradiol Tablets after induced abortion
[J]. 中国当代医药, 2020,27(4): 136-138')" href="#">
ZHENG Li-li
2020 Vol. 27 (4): 136-138 [
Abstract
] (
61
)
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13
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139
Effect of pre-pregnancy body mass index and weight change during pregnancy on pregnancy outcomes of pregnant women with gestational diabetes mellitus
Effect of pre-pregnancy body mass index and weight change during pregnancy on pregnancy outcomes of pregnant women with gestational diabetes mellitus
[J]. 中国当代医药, 2020,27(4): 139-142')" href="#">
HUANG Ying
[Abstract]
Objective
To investigate the effect of pre-pregnancy body mass index（BMI）and weight changes during pregnancy on pregnancy outcomes in pregnant women with gestational diabetes mellitus（GDM）.
Methods
A total of 242 pregnant women with GDM who were admitted and delivered in our hospital from March 2016 to April 2018 were enrolled as subjects.According to the pre-pregnancy BMI，the pregnant women were divided into underweight group（n=39），standard-weight group（n=158），overweight-obese group（n=45）.In addition，according to the weight gain during pregnancy，all the participants were divided into insufficient weight gain group（n=22），normal weight gain group（n=90），excess weight gain group（n=130）.The blood glucose level，delivery mode and pregnancy outcomes of the 242 pregnant women were recorded.
Results
Fasting blood glucose and 1-hour postprandial blood glucose in the overweight-obese group were higher than those in the underweight group and standard-weight group，with statistically significant differences（P＜0.05）.The fasting blood glucose in the standard-weight group was higher than that in the underweight group，with statistically significant difference（P＜0.05）.There were statistically significant differences in the incidence rates of cesarean section，giant infants，low-birth-weight infants，neonatal asphyxia，fetal distress，postpartum hemorrhage and preterm birth in the overweight-obese group，standard-weight group，and underweight group（P＜0.05）.There were statistically significant differences in the incidence rates of cesarean section，giant infants，low-birth-weight infants，neonatal asphyxia，fetal distress，postpartum hemorrhage and preterm birth in the insufficient weight gain group，normal weight gain group，and excess weight gain group（P＜0.05）.
Conclusion
Pre-pregnancy BMI can affect the blood glucose level of pregnant women during GDM，especially in fasting blood glucose and 1-hour postprandial blood glucose.The influencing factors of GDM pregnant women′s pregnancy outcome might be pre-pregnancy BMI and pregnancy weight gain.Pregnant women with GDM should pay attention to reasonable weight management during pregnancy.
2020 Vol. 27 (4): 139-142 [
Abstract
] (
73
)
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143
Clinical effect of Recombinant Human Erythropoietin combined with Iron Sucrose in the treatment of moderate anemia after myomectomy
Clinical effect of Recombinant Human Erythropoietin combined with Iron Sucrose in the treatment of moderate anemia after myomectomy
[J]. 中国当代医药, 2020,27(4): 143-145')" href="#">
GUAN Wen-chang BAI Feng▲ LI Hui
[Abstract]
Objective
To explore the effect of Recombinant Human Erythropoietin（rhEPO）combined with Iron Sucrose in the treatment of moderate anemia after myomectomy.
Methods
Fifty-nine patients with uterine fibroids complicated with moderate anemia treated in our hospital from May 2017 to May 2018 were selected as subjects.They were divided into study group（30 cases）and control group（29 cases）by the random number table method.Myomectomy was performed in both groups.The control group was treated with Iron Sucrose，and the study group was treated with rhEPO combined with Iron Sucrose.The clinical efficacy of the two groups was compared，and the hemoglobin（Hb）and mean erythrocyte volume（MCV）levels before operation and on the 5
th
and 14
th
day after operation were compared between the two groups.
Results
Levels of Hb（[92.15±11.30]，[103.47±12.17]g/L）and MCV（[75.23±10.13]，[79.05±10.14]fl）in the study group on the 5
th
and 14
th
day after operation were higher than those before operation（[79.1±10.03]g/L，[71.45±10.81]fl），the differences were statistically significant（P＜0.05）.Levels of Hb（[92.01±10.83]，[94.37±11.8]g/L）and MCV（[75.15±10.43]，[75.18±10.21]fl）in the control group on the 5
th
and 14
th
day after operation were higher than those before operation（[78.32±11.05]g/L，[71.41±10.96]fl），the differences were statistically significant（P＜0.05）.There were no significant differences in the Hb and MCV between the two groups before operation and on the 5
th
day after operation（P＞0.05）.The levels of Hb and MCV were higher in observation group than those in control group on the 14
th
day after operation，the differences were statistically significant（P＜0.05）.The total effective rate（93.33%）in the study group was higher than that in the control group（72.41%），and the difference was statistically significant（P＜0.05）.
Conclusion
Compared with Iron Sucrose alone，rhEPO combined with Iron Sucrose can relieve moderate anemia after myomectomy.Besides，the curative effects become better over time.
2020 Vol. 27 (4): 143-145 [
Abstract
] (
72
)
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146
Clinical effect of Montelukast Sodium in the treatment of cough variant asthma in children
Clinical effect of Montelukast Sodium in the treatment of cough variant asthma in children
[J]. 中国当代医药, 2020,27(4): 146-148')" href="#">
HU Xin
[Abstract]
Objective
To explore the clinical effect of Montelukast Sodium in the treatment of cough variant asthma in children.
Methods
A total of 80 children with cough variant asthma treated in our hospital from January 2016 to December 2018 were selected as the research subjects，they were divided into the control group（40 cases）and the observation group（40 cases）according to the random sequential method.The control group was treated with routine therapy，and the observation group was treated with Montelukast Sodium on the basis of routine therapy.The clinical effect and incidence of adverse reactions of the two groups were compared.
Results
The total effective rate of the observation group was 95.00%，which was higher than 80.00% of the control group，the difference was statistically significant（P＜0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P＞0.05）.
Conclusion
Montelukast Sodium can improve the clinical treatment effect of children with cough variant asthma without increasing adverse reactions，which is worthy of clinical application.
2020 Vol. 27 (4): 146-148 [
Abstract
] (
68
)
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149
Application effect of COOK cervical balloon combined with Oxytocin on induction of labor in high-risk pregnant women
Application effect of COOK cervical balloon combined with Oxytocin on induction of labor in high-risk pregnant women
[J]. 中国当代医药, 2020,27(4): 149-151')" href="#">
ZENG Xiang-ping
[Abstract]
Objective
To investigate the application effect of COOK cervical balloon combined with Oxytocin on induction of labor in high-risk pregnant women.
Methods
A total of 58 high-risk pregnant women admitted to our hospital from January 2017 to January 2019 were selected as the research subjects，they were divided into the observation group（30 cases）and the control group（28 cases）using the random number table method.The control group used Oxytocin to induce labor，and the observation group used COOK cervical balloon combined with Oxytocin to induce labor.The terms of childbirth，clinical effects of promoting cervical maturity，total incidence of complications，and Apgar scores of newborns were compared between the two groups.
Results
The total labor duration of the observation group was shorter than that of the control group，the number of medications was fewer than that of the control group，the incidence of postpartum hemorrhage and cesarean section rates were lower than those of the control group，the differences were statistically significant（P＜0.05）.The total effective rate of cervical maturation in the observation group was higher than that in the control group，the difference was statistically significant（P＜0.05）.There were no significant differences in the total incidence of postpartum complications and Apgar scores between the two groups（P＞0.05）.
Conclusion
COOK cervical balloon combined with Oxytocin for induction of labor in high-risk pregnant women can shorten the total labor process，reduce the number of medications，postpartum hemorrhage and cesarean section，improve the effect of induction of labor，without increasing postpartum complications and the Apgar score of newborns，which is worthy of clinical application.
2020 Vol. 27 (4): 149-151 [
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] (
66
)
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152
Monitoring the role of orthokeratology lens in the prevention and control of myopia in adolescents by axial measurement
TANG Hao-ying； LING Hong-jing WU Xiu-qun MING Guo-ying HUANG Dan-ju LI Qi-yi
Objective
Through eye axis measurement，the role of orthokeratology lens in prevention and control of juvenile myopia was discussed.
Methods
A total of 120 cases of juvenile myopic patients who visited our hospital from May 2017 to May 2018 were selected as research objects and divided into observation group and control group according to random number table method，60 cases in each group.Patients in the observation group were wearing orthokeratology lens and monitored by ocular axis measurement，while patients in the control group were wearing conventional frame glasses.The intervention process was one year.Patients were followed up every 3 months and glasses were changed according to diopter changes.The diopter，corneal curvature，axial length，uncorrected visual acuity and intraocular pressure of the two groups of patients before and one year after intervention were compared.By recording the measured data of follow-up every 3 months，the linear correlation analysis was carried out on the relationship between ocular axis and diopter，corneal curvature，naked eye vision and intraocular pressure.
Results
One year after the intervention，the diopter of the patients in the observation group was lower than that in the control group，and the naked eye vision was higher than those in the control group，the axial length of the patients in the observation group was shorter than that in the control group，the differences were statistically significant（P＜0.05）.Linear correlation analysis showed that the ocular axis was positively correlated with diopter（r=0.783，P=0.002）.The ocular axis was negatively correlated with corneal curvature（r=-0.494，P=0.041）.
Conclusion
Orthokeratology lens can effectively control the growth of ocular axis and improve the naked eye vision of juvenile myopia patients.It has good clinical efficacy and application value.
2020 Vol. 27 (4): 152-154转158 [
Abstract
] (
85
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155
Clinical effect of lateral wall resection of middle turbinate in patients with sinusitis undergoing endoscopic sinus surgery
CAO Jia-long； LIN Wei-zhou； YUAN Ya-min
Objective
To investigate the clinical effect of lateral wall resection of middle turbinate in patients with sinusitis undergoing endoscopic sinus surgery.
Methods
From January 2014 to June 2018，200 patients with sinusitis undergoing endoscopic sinus surgery were selected as the subjects，and divided into control group and study group by random number table method，with 100 cases in each group.Routine sinus surgery was performed in the control group，and lateral wall resection of the middle turbinate was performed in the study group.The patients in the two groups were followed up for 6 to 12 months.The clinical therapeutic effect，clinical symptom score and quality of life score before and after treatment，adverse reactions were compared between the two groups.
Results
The total effective rate of clinical treatment in the study group was 96.00%，which was higher than that of the control group（88.00%），the difference was statistically significant（P＜0.05）.The nasal congestion score of the study group was（3.30±1.15）points，and the nasal leakage score was（4.05±1.20）points，the olfactory disorder score was（3.20±1.15）points，and the head and face pain score was（3.25±1.06）points，which were lower than those in the control group of（5.15±1.25），（5.35±1.85），（4.20±1.05），（4.80±1.55）points，the differences were statistically significant（P＜0.05）.The overall health score of the study group after treatment was（74.45±12.65）points，and the physiological function score was（72.80±13.90）points，the score of physiological function was（65.65±10.40）points，the score of somatic pain was（69.95±11.50）points，the score of vitality was（80.50±14.75）points，the score of social function was（81.60±14.55）points，and the score of emotional function was（90.30±12.50）points，the mental health score was（76.75±13.70）points，which were higher than those in the control group of（62.50±10.10），（66.30±10.35），（58.80±8.70），（63.80±10.65），（71.40±12.50），（74.70±12.05），（77.45±13.50），（66.75±12.40）points，the differences were statistically significant（P＜0.05）.The total incidence of adverse reactions in the study group was 10.00%，which was lower than that of the control group（15.00%），and the difference was statistically significant（P＜0.05）.
Conclusion
The effect of the lateral wall resection of the middle turbinate during endoscopic sinusitis is accurate，which is worthy of clinical application.
2020 Vol. 27 (4): 155-158 [
Abstract
] (
64
)
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159
Clinical effect of fenestration negative pressure suction in the treatment of jaw cyst
ZHENG Zhi-xun； ZHAI Min； XIE Tian-tian； HUANG Hong； LIN Zhi-rui
Objective
To explore the clinical effect of fenestration negative pressure suction in the treatment of jaw cyst.
Methods
Forty patients with jaw cyst admitted to our hospital from February 2015 to February 2016 were selected as the research objects，and were divided into control group and observation group according to different surgical plans，with 20 cases in each group.Patients in the control group were treated by curettage of jaw cyst，while patients in the observation group were treated by fenestration negative pressure suction.The operation time，intraoperative blood loss，incidence of postoperative pain and numbness，incidence of postoperative infection and relapse rate within 3 years after operation were compared between the two groups.
Results
The operation time of the patients in the observation group was shorter than that of the control group，the amount of intraoperative hemorrhage was less than that of the control group，the incidence rate of postoperative pain numbness and infection were lower than those of the control group，and the relapse rate of the patients in the observation group within 3 years after operation was lower than that of the control group，the differences were statistically significant（P＜0.05）.
Conclusion
Fenestration negative pressure suction is a simple，reliable，less traumatic，less bleeding，less postoperative complications and low relapse rate treatment of jaw cyst，and the effect is obviously superior to jaw cyst curettage and is worthy of clinical application and promotion.
2020 Vol. 27 (4): 159-161 [
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] (
72
)
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162
Application of different sedation methods in awake tracheal intubation under the visible soft laryngoscope
LAI Shang-dao； CHEN Wei-yuan； YE Ruan-hao； PENG Zong-hai； SUN Mian-sheng
Objective
To explore the application effect of different sedation methods in awake tracheal intubation under the visible soft laryngoscope.
Methods
Forty patients with difficult airway who underwent elective surgery under intubation general anesthesia from January 2018 to January 2019 in our hospital were enrolled.The patients underwent awake tracheal intubation under the visible soft laryngoscope，and were divided into Dexmedetomidine group（n=20）and Midazolam group（n=20）according to different sedation methods.Patients in the Dexmedetomidine group were sedated with Dexmedetomidine，and patients in the Midazolam group were sedated with Midazolam.The mean arterial pressure（MAP），heart rate（HR），oxygen saturation（SpO
2
），and respiratory rate（RR）at 10minutes after admission（T
0
），10minutes（T
1
）after medication，immediate after successful intubation（T
2
），and 10minutes after intubation（T
3
）were observed.The total intubation time，the total incidence rate of adverse reactions，and the success rate of one intubation were compared between the two groups of patients.
Results
At T
0
，there were no significant differences in MAP，HR，SpO
2
and RR between the two groups（P＞0.05）.At T
1
，the differences in MAP，HR，SpO
2
，and RR between the two groups were statistically significant（P＜0.05）.The MAP，HR，SpO
2
，and RR at T
1
in the Midazolam group were lower than those at T
0
，and the MAP and HR in the Dexmedetomidine group at T
1
were lower than those at T
0
，with statistically significant differences（P＜0.05）.There were no significant differences in SpO
2
and RR between T
1
and T
0
in the Dexmedetomidine group（P＞0.05）.At T
2
，the differences in MAP，HR，SpO
2
，and RR between the two groups were statistically significant（P＜0.05）.In the Dexmedetomidine group，the MAP and HR at T
2
were lower than those at T
0
，and the differences were statistically significant（P＜0.05）.There were no significant differences in SpO
2
and RR between T
2
and T
0
in the Dexmedetomidine group（P＞0.05）.There were no significant differences in MAP and HR between T
2
and T
0
in the Midazolam group（P＞0.05）.There were statistically significant differences in SpO
2
，RR between T
2
and T
0
in the Midazolam group（P＜0.05）.At T
3
，there were no significant differences in MAP，HR，and SpO
2
between the two groups（P＞0.05）.There were statistically significant differences in MAP and HR between T
3
and T
0
in the two groups（P＜0.05）.There was no significant difference in SpO
2
between T
3
and T
0
in the two groups（P＞0.05）.The total intubation time in the Dexmedetomidine group was shorter than that in the Midazolam group，and the difference was statistically significant（P＜0.05）.The total incidence rate of adverse reactions in the Dexmedetomidine group was lower than that in the Midazolam group，with significant difference（P＜0.05）.The success rate of one intubation in the Dexmedetomidine group was higher than that in the Midazolam group，and the difference was statistically significant（P＜0.05）.
Conclusion
Compared with Midazolam，Dexmedetomidine has great advantages and effect in awake tracheal intubation under visual soft laryngoscope，which can not only reduce the intubation stress response，but also has a stable hemodynamic level.It can reduce the incidence of adverse reactions and is worthy of clinical promotion.
2020 Vol. 27 (4): 162-165转169 [
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55
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166
Effect of low tidal volume combined with positive end-expiratory pressure on respiratory function of single lung ventilation
TIAN Yu； CHANG Yi
Objective
To investigate the effect of low tidal volume combined with positive end-expiratory pressure on respiratory function of single lung ventilation.
Methods
From May 2018 to April 2019，80 patients undergoing general anesthesia thoracotomy under double-lumen endotracheal intubation admitted to our hospital were selected as research objects，and divided into observation group（40 cases）and control group（40 cases）according to the random number table method.For respiratory parameters of one lung ventilation，the control group was given conventional mode，while the observation group was given low tidal volume combined with positive end-expiratory pressure.The anesthesia recovery conditions of the two groups of patients（time of opening eyes，removing tracheal catheter and indwelling in recovery room），Ramsay score in recovery period 30min and 2 h after anesthesia stop，changes of pulmonary function index（percentage of forced expiratory volume in the first second to the expected value [FEV
1
%]and forced vital capacity/whole vital capacity in the first second [FEV
1
/FVC]）after operation 24h，and the occurrence of adverse reactions（hypoxemia，respiratory depression and hypercapnia）of the two groups patients were compared.
Results
The observation group had shorter time to open eyes，pull out endotracheal tube and indwelling in resuscitation room than the control group（P＜0.05）.The Ramsay score of the observation group were higher than those of the control group 30min and 2 h after anesthesia was stopped（P＜0.05）.At 24h after operation，FEV
1
% and FEV
1
/FVC in the observation group were higher than those in the control group（P＜0.05）.The total incidence of adverse reactions in the observation group was lower than that in the control group，and the difference was statistically significant（P＜0.05）.
Conclusion
For patients with one lung ventilation，low tidal volume and low positive end-expiratory pressure ventilation can effectively maintain the lung function of patients，promote anesthesia recovery of patients，and reduce the occurrence of respiratory-related complications.
2020 Vol. 27 (4): 166-169 [
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] (
65
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170
Application effect of Dexmedetomidine in patients undergoing total hip replacement
ZHOU Xiao-feng； LI Li-ting； GU Su-ya； Su Yu-qing； WU Cai-yuan
Objective
To investigate the application effect of Dexmedetomidine in patients undergoing total hip replacement.
Methods
A total of 78 patients who underwent total hip replacement treated in our hospital from January 2017 to December 2018 were selected as the subjects，and divided into control group and observation group by random number table method，with 39 cases in each group.The observation group received Dexmedetomidine 0.50 μg/kg intravenous infusion of 20 ml before induction of anesthesia，while the control group received the same amount of saline intravenously.The recovery of anesthesia and the occurrence of restlessness were compared between the two groups，and the scores of analgesia and sedation（Ramsay）at 6，12 and 24h after operation were compared.
Results
There was no significant difference in spontaneous breathing recovery time and eye opening time between the two groups（P＞0.05）.The incidence of restlessness in the observation group was lower than that in the control group，and the difference was statistically significant（P＜0.05）.The visual analogue scale（VAS）scores of the two groups at 24hours after operation were lower than that at 12 hours after operation，and the VAS scores at 12 hours after operation were higher than that at 6 hours after operation，and the differences were statistically significant（P＜0.05）.There was no significant difference in VAS scores between the two groups at 24hours after operation and 6 hours after operation（P＞0.05）.The VAS scores of the observation group at 6，12 hours and 24hours after operation were lower than those of the control group，and the differences were statistically significant（P＜0.05）.The Ramsay scores of the two groups at 24hours after operation were lower than those at 12 hours after operation，and the Ramsay scores of the two groups at 12 hours after operation were lower than those at 6 hours after operation，and the differences were statistically significant（P＜0.05）.The Ramsay scores of the observation group at 6，12 hours and 24hours after operation were higher than those of the control group，and the differences were statistically significant（P＜0.05）.
Conclusion
The application of Dexmedetomidine in patients undergoing total hip replacement does not significantly prolong the recovery time of anesthesia，and it can reduce the incidence of restlessness and obtain better sedative and analgesic effects.
2020 Vol. 27 (4): 170-172转176 [
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80
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173
Effect of Dexamethasone, Metoclopramide and Tropisetron on prevention of nausea and vomiting induced by Carboprost Tromethamine during cesarean section
ZHANG Pei-cai； LI Miao； XU Hui-xia
Objective
To investigate the effect of Dexamethasone，Metoclopramide and Tropisetron on preventing nausea and vomiting induced by Carboprost Tromethamine during cesarean section.
Methods
From January 2015 to January 2018，200 parturients who were applied Carboprost Tromethamine during caesarean section under combined spinal-epidural anesthesia in our hospital were selected as the research objects，and divided into 4 groups according to the random number table method，with 50 cases in each group.Patients were given different drugs before operation to prevent nausea and vomiting during operation.Group D was given Dexamethasone 5 mg; Group J was given Dexamethasone 5 mg+ Metoclopramide 10 mg; Group T was given Dexamethasone 5 mg+ Metoclopramide 10 mg+ Tropisetron 5 mg; Control group was given 5 ml of 0.9% sodium chloride solution.To observe and compare the incidence of nausea and vomiting and adverse reactions（extrapyramidal reactions）after Carboprost Tromethamine was applied to parturients in each group for 5，6-15，16-30，31-50min.
Results
The incidence rates of nausea and vomiting in groups D，J and T were lower than that in the control group at all time points after medication（P＜0.05）.The incidence ratesof nausea and vomiting in different time periods were different between groups D，J and T（P＜0.05）.The incidence rates of nausea and vomiting in group J and T were lower than that in group D 5min after medication（P＜0.05）.There was no significant difference in nausea and vomiting incidence between J and T groups（P＞0.05）.The incidence rates of nausea and vomiting in group J and group T were lower than that in group D at 6-15，16-30 and 31-50min after medication（P＜0.05）.The incidence rates of nausea and vomiting in group T were lower than that in group J（P＜0.05）.One case of suspected extrapyramidal reaction occurred in group J，and no adverse reactions occurred in other groups.
Conclusion
Dexamethasone+Metoclopramide+Tropisetron combined use has definite effect in preventing nausea and vomiting during cesarean section，which is worthy of further clinical research and application.
2020 Vol. 27 (4): 173-176 [
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72
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177
Effect comparison of intravenous anesthesia and inhalation anesthesia in painless fiberbronchoscopy
WANG Wei-xue； HUO Xiao-bei
Objective
To compare the effect of intravenous anesthesia and inhalation anesthesia in painless fiberbronchoscopy.
Methods
Eighty patients with respiratory diseases who needed fiberbronchoscopy in our hospital from October 2018 to May 2019 were selected as the study objects，they were divided into control group（40 cases）and observation group（40 cases）according to the random number table method.The observation group was given intravenous anesthesia and the control group was given inhalation anesthesia.The intraoperative vital signs，operation time，anesthesia recovery time and the total incidence of complications were compared between the two groups.
Results
The heart rate and mean arterial pressure of the observation group were lower than those of the control group，and the blood oxygen saturation and respiratory rate were higher than those of the control group，the differences were statistically significant（P＜0.05）.The operation time and anesthesia recovery time in the observation group were shorter than those in the control group，the differences were statistically significant（P＜0.05）.The total incidence of complications in the observation group was lower than that in the control group，the difference was statistically significant（P＜0.05）.
Conclusion
General intravenous anesthesia can keep the vital signs stable，shorten the operation time and anesthesia recovery time，reduce the occurrence of complications，which is worthy of clinical application.
2020 Vol. 27 (4): 177-179 [
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66
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180
Application value of MR diffusion kurtosis imaging in the microstructural changes of frontal cortex in patients with mild cognitive impairment
WANG Qing-bo； ZHAO Yang； WANG Jia-fu
Objective
To analyze the application value of MR diffusion kurtosis imaging（DKI）in the microstructural changes of the frontal cortex of patients with mild cognitive impairment（MCI）.
Methods
The clinical data of 93 patients with cerebral small vessel disease treated in our hospital from May 2018 to April 2019 were retrospectively analyzed.Among them，45 patients without MCI were selected as the control group，and 48 patients with MCI were selected as the observation group.Both groups received regular MR and DKI scanning.The mean kurtosis（MK），axial kurtosis（AK），and diffusion fraction anisotropy（FA）values of the two groups in interest area were compared.
Results
The MK of the right anterior and side cingulate cerebral gyrus of the observation group was（0.66±0.08）mm
2
/s，AK was（0.63±0.07）mm
2
/s，and FA was（0.16±0.04）mm
2
/s，which lower than those in the control group for（0.72±0.05），（0.69±0.05），（0.19±0.02）mm
2
/s，respectively，and the differences were statistically significant（P＜0.05）.There were no significant differences in the MK，AK and FA values of the left anterior cingulate and side cingulate cerebral gyrus and the bilateral dorsolateral gyrus between the two groups（P＞0.05）.
Conclusion
DKI technology can be used as an effective way to observe the microstructural changes of the frontal cortex in patients with MCI，and the MK，AK，FA parameters can provide important information for clinical evaluation.
2020 Vol. 27 (4): 180-182 [
Abstract
] (
66
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183
Application value of dynamic contrast-enhanced magnetic resonance scanning in the diagnosis of prostate cancer
LI Zhi-gang
Objective
To explore the application value of dynamic contrast-enhanced magnetic resonance scanning（DCE-MRI）in the diagnosis of prostate cancer.
Methods
A total of 200 patients suspected with prostate cancer in our hospital from March 2015 to March 2019 were selected as the study subjects，all patients were examined by CT and DCE-MRI.The diagnostic efficacy，sensitivity，specificity and accuracy of the two methods were compared.
Results
The positive detection rate of DCE-MRI was higher than that of CT，the difference was statistically significant（P＜0.05）.The sensitivity，specificity and accuracy of DCE-MRI examination were higher than those of CT examination，the differences were statistically significant（P＜0.05）.
Conclusion
DCE-MRI has a high value in the diagnosis of prostate cancer，which can provide some basis for the later treatment.
2020 Vol. 27 (4): 183-185 [
Abstract
] (
71
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186
Value of transvaginal three-dimensional hysterosonography in diagnosis of intrauterine adhesions
TU You-mei； CHEN Guan-chun； LYU Xiao-liang
Objective
To explore the value of transvaginal three-dimensional hysterosonography in diagnosis of intrauterine adhesions.
Methods
From January 2017 to December 2018，36 patients with suspected intrauterine adhesions admitted to the gynecology clinic of our hospital were selected as the research objects.All patients were examined by transvaginal three-dimensional ultrasound first，then by transvaginal three-dimensional hysterography，and finally 28 patients with intrauterine adhesions were diagnosed by hysteroscopy.The positive rate，missed diagnosis rate，misdiagnosis rate，correct rate，sensitivity and specificity of the two diagnostic methods were compared.
Results
The positive rate of transvaginal three-dimensional hysterosonography was higher than that of transvaginal three-dimensional ultrasonography（P＜0.05）.The missed diagnosis rate and misdiagnosis rate of transvaginal three-dimensional hysterosonography were lower than those of transvaginal three-dimensional ultrasonography（P＜0.05）.The accuracy rate of transvaginal three-dimensional hysterosonography was higher than that of transvaginal three-dimensional ultrasonography（P＜0.05）.The sensitivity and specificity of transvaginal three-dimensional hysterosonography were higher than those of transvaginal three-dimensional ultrasonography（P＜0.05）.
Conclusion
Transvaginal three-dimensional uterine cavity contrast-enhanced ultrasound can diagnose intrauterine adhesion more accurately.Compared with common transvaginal three-dimensional ultrasound，it has the advantages of missed diagnosis rate，low misdiagnosis rate，high accuracy rate，and is worthy of further promotion in clinical practice.
2020 Vol. 27 (4): 186-188转192 [
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] (
63
)
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189
Effect of Huayu Xiaozheng Decoction combined with external application of Chinese herbal medicine in the treatment of ectopic pregnancy
WANG Bao-zhen
Objective
To observe the effect of Huayu Xiaozheng Decoction combined with external application of Chinese herbal medicine in the treatment of ectopic pregnancy.
Methods
A total of 82 ectopic pregnancy patients who underwent conservative treatment in our hospital from January 2016 to May 2019 were selected as subjects.By the random number table method，they were divided into the control group and the observation group，41 cases in each group.The control group was treated with Huayu Xiaozheng Decoction in oral administration.On the basis of the control group，Xiaozheng Powder for external application was added to the observation group.The curative effect and recovery including the mass disappearance time，abdominal pain disappearance time，vaginal bleeding disappearance time，and the time returning to normal on β-human chorionic gonadotropin（β-HCG）level after treatment were observed between the two groups.The changes of progesterone（P）and β-HCG levels before and after treatment and the incidence of adverse reactions were compared between the two groups.
Results
In the observation group，the total effectiveness rate was higher than that of the control group，with statistical significance（P＜0.05）.In the observation group，the mass disappearance time，abdominal pain disappearance time，vaginal bleeding disappearance time，and the time returning to normal on β-HCG level were shorter than those of the control group，the differences were statistically significant（P＜0.05）.After treatment，the P level in the observation group was higher than that in the control group，and the β-HCG level was lower than that in the control group，the differences were statistically significant（P＜0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P＞0.05）.
Conclusion
Conservative treatment of Huayu Xiaozheng Decoction combined with external application of Chinese herbal medicine in the treatment of ectopic pregnancy has a remarkable effect，which improves the level of relevant serum indicators with high safety.
2020 Vol. 27 (4): 189-192 [
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] (
85
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193
Effect of self-made nourishing liver and kidney prescription in the treatment of climacteric syndrome
YAO Xin-yi
Objective
To study the effect of self-made nourishing liver and kidney prescription in the treatment of climacteric syndrome，and to provide guidance for the treatment of patients.
Methods
The clinical data of 300 patients with climacteric syndrome treated in our hospital from January 2017 to January 2019 were retrospectively analyzed.According to the different treatment methods，they were divided into observation group and control group，with 150 cases in each group.The patients in the control group were treated with hormone replacement therapy，while the patients in the observation group were treated with self-made nourishing liver and kidney prescription on basis of the treatment in the control group.The clinical treatment effect，self-diagnosis assessment form for female climacteric syndrome（Kupperman）score，blood lipid levels，sex hormone levels and adverse reactions of the two groups were observed and compared.
Results
The Kupperman scores of the observation group were lower than those of the control group after 2 and 3 months of treatment，the differences were statistically significant（P＜0.05）.The follicle stimulating hormone（FSH），low density lipoprotein cholesterol（LDL-C），triglyceride（TG）and serum total cholesterol（TC）levels in the observation group were lower than those in the control group after treatment，while the estradiol（E
2
）and high density lipoprotein cholesterol（HDL-C）levels were higher than those in the control group，and the differences were statistically significant（P＜0.05）.The total effective rate of treatment in the observation group was 97.3%，which was higher than that in the control group（74.7%），the difference was statistically significant（P＜0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P＞0.05）.
Conclusion
The application of nourishing liver and kidney prescription in the treatment of climacteric syndrome patients has obvious clinical symptoms and high safety，which is worthy of clinical promotion.
2020 Vol. 27 (4): 193-196 [
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] (
72
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197
Clinical effect of thermal moxibustion combined with Xinjia Xiangru Drink in the treatment of yinshu
ZHU Su-you; QI Gong-cheng; DU Ting-ting; XU Zhong-bo; YAO Liang-liang
Objective
To investigate the clinical effect of thermal moxibustion combined with Xinjia Xiangru Drink in the treatment of yinshu.
Methods
A total of 58 patients with yinshu syndrome who were admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from June 21，2016 to August 23，2017 were selected as the study subjects.They were divided into control group and treatment group by random number table method，29 cases in each group.The patients in the treatment group were treated with thermal moxibustion combined with Xinjia Xiangru Drink，and the patients in the control group were treated with Xinjia Xiangru Drink.The traditional Chinese medicine symptom scores before and after treatment and the total therapeutic effective rate were observed between the two groups.
Results
After treatment，the symptom scores of mental exhaustion，dizziness and drowsiness，chest tightness，no sweat or less sweat，fever and aversion to cold，nausea and vomiting，thirst without desire to drink and the total score of patients in the two groups were lower than those before treatment，the differences were statistically significant（P＜0.05）.After treatment，the symptom scores of mental exhaustion，dizziness and drowsiness，chest tightness，no sweat or less sweat，fever and aversion to cold，nausea and vomiting，thirst without desire to drink and the total score of patients in the treatment group were lower than those in the control group，the differences were statistically significant（P＜0.05）.The total effective rate of the treatment group was higher than that of the control group，and the difference was statistically significant（P＜0.05）.
Conclusion
The clinical effect of using thermal moxibustion combined with Xinjia Xiangru Drink in the treatment of yinshu is significant，it is worthy of clinical application and promotion.
2020 Vol. 27 (4): 197-200 [
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74
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201
Effects of estradiol, progesterone and β-human chorionic gonadotropin levels and their trends on pregnancy outcomes
LI Ming-feng
Objective
To investigate the predictive value of estradiol（E
2
），progesterone and β-human chorionic gonadotropin（β-HCG）levels and their trends on pregnancy outcomes.
Methods
The clinical data of 80 early pregnant woman who were admitted to our hospital from November 2017 to November 2018 were retrospectively analyzed.According to the pregnancy outcome at 12 weeks of gestation，they were divided into the continuing pregnancy group（54 cases）and the missed abortion group（26 cases）.Combined with the history of the initial diagnosis，33 patients in the continuing pregnancy group had no symptoms of threatened abortion（group A），and 21 patients had symptoms of threatened abortion（group B）.In the missed abortion group，17 patients had no symptoms of threatened abortion（group C），and 9 patients had symptoms of threatened abortion（group D）.The levels of E
2
，progesterone and β-HCG in the first consultation day and their daily rate of change of the continuing pregnancy group and the missed abortion group were compared.The levels of E
2
，progesterone and β-HCG in groups A，B，C and D were compared at 12 weeks of gestation.
Results
The levels of E
2
and progesterone in the first trimester of the continuing pregnancy group were higher than those in the missed abortion group，and the daily change rates of E
2
and progesterone were higher than those in the missed abortion group，the differences were statistically significant（P＜0.05）.There was no significant difference between the two groups in the level of β-HCG and the daily change rate（P＞0.05）.At 12 weeks of gestation，the levels of E
2
and progesterone in the four groups were significantly different（P＜0.05）.There was no significant difference in the level of β-HCG between the four groups（P＞0.05）.The levels of E
2
and progesterone in group A and B were higher than those in group C and D，the differences were statistically significant（P＜0.05）.There were no significant differences in E
2
and progesterone levels between group A and B（P＞0.05）.And there were no significant differences in E
2
and progesterone levels between group C and D（P＞0.05）.
Conclusion
The first E
2
and progesterone levels and their changing trend have certain guiding significance for the outcome of pregnancy.Higher levels and greater increases in E
2
and progesterone indicate good pregnancy outcomes.
2020 Vol. 27 (4): 201-203转212 [
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61
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204
Diagnostic value of routine blood examination and serum ferritin examination in iron deficiency anemia infection
GUAN Xi-hua
Objective
To explore the diagnostic value of routine blood examination and serum ferritin examination in iron deficiency anemia infection.
Methods
Sixty-eight patients suspected with iron deficiency anemia infection in our hospital from February 2018 to April 2019 were selected as the study objects，all patients received routine blood tests and serum ferritin tests.The sensitivity，specificity and accuracy of the two methods were compared.
Results
Among 68 patients suspected with iron deficiency anemia infection，50 cases were diagnosed as iron deficiency anemia infection by pathological examination，and 18 cases were non iron deficiency anemia infection.41 patients were diagnosed as iron deficiency anemia infection by serum ferritin，and 27 cases were detected in negative.46 patients were diagnosed as iron deficiency anemia infection by blood routine examination，and 22 cases were detected in negative，there were no significant differences in sensitivity，specificity and accuracy between the two methods（P＞0.05）.
Conclusion
The sensitivity，specificity and accuracy of routine blood test and serum ferritin test in patients with iron deficiency anemia infection are similar.The clinical examination method should be selected according to the actual situation of patients.
2020 Vol. 27 (4): 204-206 [
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89
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207
Comprehensive analysis of adverse drug reaction reports of antibiotics in a city
HU Hua; XIANG Wei; YE Ming-quan
Objective
To analysis the adverse drug reaction（ADR）reports of all hospitals in a city from January 2014 to December 2016，and compare the characteristics of the data to reduce the incidence of adverse reactions and promote the rational use of antibiotics in the clinic.
Methods
A retrospective analysis of 5630 ADRreports of antibiotics in a city from January 2014 to December 2016 was carried out.The ADRincidence of antibiotics in different gender，ages and routes of administration were analyzed by computer analysis system.The severity of new ADRand all ADRs of antibiotics were analyzed.New serious ADRinvolving systemic organs and clinical manifestations of antibiotics were analyzed.The outcome of antibiotic ADRafter symptomatic treatment were analyzed.The occurrence of ADRin different antibiotics were analyzed.
Results
A total of 5630 antibiotics ADRreports，2617 were male（46.48%），3004 were female（53.36%），and 9 were unknown（0.16%）.The age of ADRcaused by antibiotics was mostly between 1-10 and ＞40-70 years.The most frequent ADRoccured during the administration of intravenous drip.The number of new ADRwas 1047（18.60%），and the number of new ADRs in 2014 and 2015 was higher than that in 2016.According to the classification analysis of the severity of ADR，171 cases（3.04%）of severe ADRwere reported in all reports，the severe ADRs in 2015 and 2016 were slightly higher than in 2014.In the clinical manifestations of new severe ADR，the skin and its accessories were the most severe，followed by systemic damage.In all ADRreports，a total of 3165 cases（56.42%）were cured.Among them，2014 and 2015 were basically the same and slightly decreased in 2016.A total of 2312 cases（41.21%）improved and the number of cases was basically the same in each year.A total of 20 cases had sequelae（0.36%）.Of all the ADRreports，the Levofloxacin was the most frequently occurring ntibiotic，followed by Azithromycin and Cefuroxime.
Conclusion
Appropriate routes of administration and doses should be used in clinical treatment.At the same time，the medication process must be closely monitored，and the occurrence of new ADRs must be paid attention to.The elderly and children should be given more careful clinical monitoring to ensure the safety of medication.
2020 Vol. 27 (4): 207-212 [
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] (
62
)
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213
Applicatin effect of regular health management on patients with chronic non-communicable diseases with bad living habits
DENG Xue-hui
Objective
To explore the application effect of regular health management on patients with chronic noncommunicable diseases with bad living habits.
Methods
From January 2018 to April 2019，150 patients with chronic non-communicable diseases with bad living habits were selected as the subjects.The body mass index（BMI），waist circumference，mean blood pressure（MBP），blood glucose，blood lipid and other indexes of the patients were detected.According to the test results，the patients were given regular and individualized lifestyle health management.The abnormal indexes，health behavior and health knowledge scores before and after regular health management were compared.
Results
After regular health management，the waist circumference，BMI，MBP，fasting blood glucose and TC，TG，LDLC of the patients were lower than those before regular health management，and the HDL-C was higher than that before regular health management，the differences were statistically significant（P＜0.05）.After regular health management，the percentage of drinking and smoking in healthy behavior were lower than those before regular health management，the percentage of low salt and low fat diet，exercise and health education were higher than those before regular health management，and the differences were statistically significant（P＜0.05）.After regular health management，the health knowledge score was higher than that before regular management，the difference was statistically significant（P＜0.05）.
Conclusion
Regular health management can significantly improve the poor living habits of the subjects，improve the selfawareness of prevention and treatment of chronic non-transmitted diseases，so as to slow down the development of chronic non-communicable diseases.
2020 Vol. 27 (4): 213-216 [
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56
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217
Effect of intensive health cognitive nursing on nursing effect of hospitalized patients with coronary heart disease
JIANG Yun-fei; DAI Guo-rong▲
Objective
To explore the effect of intensive health cognitive nursing on the nursing effect of hospitalized patients with coronary heart disease（CHD）.
Methods
From March to December 2018，96 hospitalized patients with CHD treated in our hospital were selected as the research objects，and were divided into observation group and control group by blind selection method，48 cases in each group.The control group was given routine nursing，while the observation group was given intensive health cognitive nursing.The knowledge of disease of patients in the two groups was compared were compared.The scores of self-rating anxiety scale（SAS）and self-rating depression scale（SDS）and nursing compliance were compared.
Results
The knowledge of disense score in the obervation group was higher than that in the control group; the scores of SAS and SDS in the observation group were lower than those in the control group，and the nursing compliance score in the observation group was higher than that in the control group.There were significant differences between the two groups（P＜0.05）.
Conclusion
Strengthening health cognitive nursing can help inpatients with CHD acquire more disease knowledge，help them effectively alleviate negative emotions such as anxiety and depression，and improve nursing compliance.The clinical effect is remarkable.
2020 Vol. 27 (4): 217-219 [
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] (
77
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220
Application effect of holistic nursing intervention in patients with multiple myeloma
ZHANG Xin; SONG Hai-xu; ZHAN Yi; LI Li; SUN Yue
Objective
To analyze the application effect of holistic nursing intervention in patients with multiple myeloma（MM）.
Methods
Forty patients with MM admitted to our hospital from June 2017 to October 2018 were selected and randomly divided into the control group（n=20）and the observation group（n=20）.The control group received routine nursing intervention，while the observation group underwent holistic nursing intervention.The pain degree，score of quality of life and nursing satisfaction of the two groups were compared.
Results
The pain degree of the observation group was lighter than that of the control group，the difference was statistically significant（P＜0.05）.The scores of life quality of the two groups were higher than those before the nursing，and the motor function and emotional function，material function，and social function scores of the observation group were higher than those of the control group，the differences were statistically significant（P＜0.05）.The nursing total satisfaction of observation group was 90.00%，higher than that of the control group for 50.00%，the difference was statistically significant（P＜0.05）.
Conclusion
Patients with MM receive holistic nursing intervention can alleviate pain and improve the quality of life.
2020 Vol. 27 (4): 220-222 [
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65
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223
Application effect of standardized nursing in male perineal ostomy patients
NIE Ai-ping； YAN Wei-qin； LIU Gui-lian ； TANG Li-ping
Objective
To investigate the application effect of standardized nursing in male perineal ostomy patients.
Methods
A total of 52 patients with perineal ostomy who were admitted to our hospital from June 2017 to March 2019 were selected objects of study.According to different nursing methods，they were divided into control group（26 cases）and observation group（26 cases）.The control group used conventional nursing methods and the observation group implemented standardized nursing on the basis of conventional nursing.The nursing effect，adverse events（fever，urinary tract infection，lymph node metastasis），the length of stay in hospital，and the quality of life before and after treatment were compared between the two groups.
Results
The total qualified rate of nursing in the observation group was higher than that of the control group，and the difference was statistically significant（P＜0.05）.The total incidence of adverse events after intervention in the observation group was lower than that in the control group，and the difference was statistically significant（P＜0.05）.The length of stay in the observation group was（10.49±4.68）d，shorter than that in the control group（[14.95±3.41]d），with statistical difference（P＜0.05）.The scores of the quality of life（except the physiological dimension）of the observation group after nursing were higher than those of the control group，and the differences were statistically significant（P＜0.05）.
Conclusion
Standardized nursing has a good effect in male perineal ostomy patients，which can improve the quality of life of patients，and it has great significance for clinical research.
2020 Vol. 27 (4): 223-225转230 [
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] (
71
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226
Application effect of cluster management in postoperative recovery of patients with peptic ulcer perforation
YE Gui-lian； YE Fen； ZHONG Mei-hua ； ZHENG Min-qi ； HAO Zhi-yong
Objective
To investigate the application effect of cluster management in postoperative recovery of patients with peptic ulcer perforation.
Methods
A total of 55 patients with peptic ulcer perforation treated in our hospital from January 2015 to September 2017 were selected as the research objects by convenient sampling method.Patients were divided into observation group（n=28）and control group（n=27）according to admission time.The control group used routine nursing method，and the observation group used cluster management method based on routine nursing.The incidence of postoperative complications，abdominal pain score at different time after surgery，first exhaust time after surgery，time from surgery to discharge，daily living ability at the third day after surgery，health knowledge mastery，and nursing satisfaction scores were observed and compared in the two groups.
Results
The total incidence of complications in the observation group was lower than that in the control group，and the difference was statistically significant（P＜0.05）.The time from surgery to discharge in the observation group was shorter than that in the control group，and the difference was statistically significant（P＜0.05）.The pain score at the third day after surgery in the observation group was lower than that in the control group，and the difference was statistically significant（P＜0.05）.The daily living ability score at the third day after surgery in the observation group was higher than that in the control group，and the difference was statistically significant（P＜0.05）.The health knowledge mastery score in the observation group was higher than that in the control group，and the difference was statistically significant（P＜0.05）.The nursing satisfaction score in the observation group was higher than that in the control group，and the difference was statistically significant（P＜0.05）.There was no significant difference in the first exhaust time after surgery between the two groups of patients（P＞0.05）.
Conclusion
Cluster management guiding the clinical implementation of evidence can significantly reduce the incidence of complications in patients with peptic ulcer perforation，improve the hospitalization experience，increase awareness of their own diseases，and promote postoperative recovery.
2020 Vol. 27 (4): 226-230 [
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66
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231
Effect of essential balm combined with alcohol on local pain in venipuncture patients
CAO Qun-mei； WANG Qiu-hua； WANG Mei-hua
Objective
To investigate the effect of essential balm combined with ethanol on local pain in patients with venipuncture.
Methods
A total of 100 patients who underwent venipuncture in our hospital from July 2018 to February 2019 were selected and divided into experimental group（50 cases）and control group（50 cases）according to different experimental methods.In the experimental group，0.3 ml of essential balm was applied to the puncture site，after 2minutes，ethanol was applied to the conventional disinfection and intravenous indwelling needle puncture，the control group was only given essential balm.Total incidence of pain and visual analogue scale（VAS）score in two groups were compared between two groups.
Results
The total incidence of pain and VAS scores in the experimental group were lower than those in the control group，the differences were statistically significant（P＜0.05）.
Conclusion
The experimental effect of essential balm combined with ethanol to reduce local pain of venipuncture is better than that of simple oil phlegm.
2020 Vol. 27 (4): 231-233 [
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82
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234
Application effect of free posture in natural delivery
WANG Yu-mei； LAN Cai-xuan； HUANG Xiao-yan
Objective
To explore the application effect of free posture in natural childbirth.
Methods
A total of 100 pregnant women in our hospital from April 2018 to April 2019 were selected as the experimental group.Another 100 pregnant women in our hospital at the same time were selected as the control group.The control group was given traditional bed position for delivery，while the experimental group was given free position for delivery.The total length of labor，natural delivery rate，cesarean section rate and total incidence of adverse reactions were compared between the two groups.
Results
The first，second and total stages of labor in the experimental group were shorter than those in the control group，with statistical differences（P＜0.05）.The natural delivery rate in the experimental group was 97.00%，higher than 80.00% in the control group，and the cesarean section rate in the experimental group was 3.00%，lower than 20.00% in the control group，with statistical differences（P＜0.05）.The total incidence of adverse reactions in the experimental group was 8.00%，lower than that in the control group for 38.00%，the difference was statistically significant（P＜0.05）.
Conclusion
Free position can shorten the average length of the first stage of labor and labor，increase the proportion of natural delivery，reduce cesarean section and medical intervention，which is worth popularizing in clinical practice.
2020 Vol. 27 (4): 234-236 [
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] (
77
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Application effect of accelerated rehabilitation surgery in repairing foot wounds of diabetic patients with pedicled flap
XIE Li-juan； YE Hui-ping； WANG Ying-qiong； CHEN Min-ting
Objective
To explore the effect of application effect of the accelerated rehabilitation surgery（ERAS）in repairing foot wounds of diabetic（DF）patients with pedicled flap.
Methods
From January 2017 to January 2019，60 DF patients admitted to our hospital were selected and divided into the control group（n=30）and the experimental group（n=30）according to the random number table method.The control group used the conventional measures while the experimental group used the measures of the ERAS during the perioperative period.The indexes such as the total rate of complications，postoperative pain score，blood glucose level，defecation time，hospital stay and flap survival rate between the two groups were compared between two groups.
Results
The total rate of complications，postoperative pain score and blood glucose level were lower in the experimental group than those in the control group，and the defecation time and hospital stay were shorter than those in the control group，and the flap survival rate was higher than that in the control group，and the differences were statistically significant（P＜0.05）.
Conclusion
In the treatment of DF patients with pedicled flaps，the application of accelerated rehabilitation surgery ERAS perioperative management can effectively reduce the occurrence of complications，improve the flap survival rate and promote rapid recovery after surgery.
2020 Vol. 27 (4): 237-239转243 [
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67
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240
Effect of individualized medical nutrition guidance during pregnancy on pregnancy outcome of perinatal pregnant women and neonates
LIN Xue-qin
Objective
To analyze the influence of individualized medical nutrition guidance during pregnancy on pregnancy outcome and neonates of pregnant women in perinatal period.
Methods
A total of 126 pregnant women in perinatal period who were admitted to our hospital from April 2017 to February 2019 were selected and divided into control group and observation group according to random number table method，63 cases in each group.The control group and the observation group received routine pregnant nursing intervention and individualized pregnant medical nutrition guidance respectively.The scores of knowledge and behavior，body mass index，incidence of pregnancy complications，pregnancy outcomes and neonatal conditions were compared between the two groups.
Results
There were significant differences in knowledge and behavior scores，body mass index，incidence of complications，pregnancy outcomes and neonatal conditions between the two groups after receiving different nursing methods（P＜0.05）.The knowledge and behavior scores of the observation group were higher than those of the control group，and the incidence of body mass index and complications of pregnancy were lower than those of the control group，pregnancy outcome and neonatal condition were better than those of control group，the differences were statistically significant（P＜0.05）.
Conclusion
Individualized nutritional guidance for pregnant women in perinatal period can significantly improve the adverse pregnancy outcomes and maintain the normal growth and development of the fetus.
2020 Vol. 27 (4): 240-243 [
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75
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10
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244
Effect of humanistic nursing intervention on maternal and infant outcomes in patients with placenta previa
SUN Cong-min
Objective
To explore the effect of humanistic nursing intervention on maternal and infant outcomes in patients with placenta previa.
Methods
A total of 200 cases of placenta previa pregnancy patients admitted to our hospital from January to December 2017 were selected as the research objects，and were randomly divided into observation group and control group according to the order of admission，100 cases in each group.The control group received routine clinical nursing intervention，and the observation group received humanistic nursing intervention.Two groups of patients before and after nursing self rating anxiety scale（SAS），self rating depression scale（SDS）score，surgery，neonatal situation were compared.
Results
After nursing，postpartum blood loss was less in the observation group than that in the control group，duration of pregnancy termination was shorter than that in the control group，neonatal body mass and Apgar score were higher than those in the control group，length of hospital stay was（[14.66±3.43]d），shorter than that in the control group（[19.52±3.56]d），and the differences were statistically significant（P＜0.05）.After nursing，SAS and SDS scores in the observation group were lower than those in the control group，and the differences were statistically significant（P＜0.05）.
Conclusion
After the humanized nursing intervention for placenta previa pregnancy patients，the pregnancy outcome and psychological mood of the patients were significantly improved，and the humanized nursing was encouraged in clinical practice.
2020 Vol. 27 (4): 244-246 [
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64
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9
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247
Application of holistic nursing based on bio-psycho-social function in perioperative period of laparoscopic surgery for patients with endometriosis
CAI Hui-ying ; ZHENG Hong
Objective
To explore the application effect of holistic nursing based on bio-psychological-social function in perioperative period of laparoscopic surgery for patients with endometriosis.
Methods
A total of 110 patients with endometriosis intending to undergo laparoscopic surgery admitted to the Shenyang Maternal and Child Hospital from October 2017 to October 2018 were selected as the study subjects.They were divided into two groups with 55 cases in each group by random number table method.The control group was given routine nursing，while the observation group was given holistic nursing of bio-psycho-social function based on the control group.The scores of self-rating depression scale（SDS），self-rating anxiety scale（SAS）and operation related indexes（hospitalization，eating and ambulation time）were compared between the two groups.
Results
SDS and SAS scores of patients in the observation group after intervention were lower than those in the control group，and the differences were statistically significant（P＜0.05）.The time of hospitalization，eating and getting out of bed in the observation group was shorter than that in the control group，the differences were statistically significant（P＜0.05）.
Conclusion
Holistic nursing of bio-psycho-social function for patients with endometriosis intending to undergo laparoscopic surgery can effectively improve the depression and anxiety status of patients and accelerate the recovery speed.
2020 Vol. 27 (4): 247-249 [
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72
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250
Application effect of comprehensive nursing intervention in patients with peptic ulcer complicated with upper gastrointestinal hemorrhage
CHANG Yan
Objective
To investigate the effect of comprehensive nursing intervention in patients with peptic ulcer complicated with upper gastrointestinal bleeding.
Methods
A total of 98 patients with peptic ulcer complicated with upper gastrointestinal hemorrhage admitted to our department from February to December 2018 were selected as subject of study.They were divided into control group（n=49）and observation group（n=49）according to random number table method，49 cases in each group.The control group received routine nursing intervention and the observation group received comprehensive nursing intervention.The effect，and the scores of anxiety and depression before and after intervention were compared between two groups.
Results
The total effective rate of the observation group was 95.92%，higher than that of the control group accounting for 79.59%，the difference was statistically significant（P＜0.05）.There was no significant difference in anxiety or depression score between the two groups before intervention（P＞0.05）.After intervention，the anxiety and depression scores of the observation group were lower than those of the control group，the differences were statistically significant（P＜0.05）.
Conclusion
Comprehensive nursing intervention can improve the effect of patients with peptic ulcer combined with upper gastrointestinal hemorrhage，and improve their anxiety and depression.
2020 Vol. 27 (4): 250-252 [
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85
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