地塞米松、甲氧氯普胺联合托烷司琼预防剖宫产术中卡前列素氨丁三醇诱发恶心呕吐的效果

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Abstract Objective To investigate the effect of Dexamethasone，Metoclopramide and Tropisetron on preventing nausea and vomiting induced by Carboprost Tromethamine during cesarean section.Methods From January 2015 to January 2018，200 parturients who were applied Carboprost Tromethamine during caesarean section under combined spinal-epidural anesthesia in our hospital were selected as the research objects，and divided into 4 groups according to the random number table method，with 50 cases in each group.Patients were given different drugs before operation to prevent nausea and vomiting during operation.Group D was given Dexamethasone 5 mg; Group J was given Dexamethasone 5 mg+ Metoclopramide 10 mg; Group T was given Dexamethasone 5 mg+ Metoclopramide 10 mg+ Tropisetron 5 mg; Control group was given 5 ml of 0.9% sodium chloride solution.To observe and compare the incidence of nausea and vomiting and adverse reactions（extrapyramidal reactions）after Carboprost Tromethamine was applied to parturients in each group for 5，6-15，16-30，31-50min.Results The incidence rates of nausea and vomiting in groups D，J and T were lower than that in the control group at all time points after medication（P＜0.05）.The incidence ratesof nausea and vomiting in different time periods were different between groups D，J and T（P＜0.05）.The incidence rates of nausea and vomiting in group J and T were lower than that in group D 5min after medication（P＜0.05）.There was no significant difference in nausea and vomiting incidence between J and T groups（P＞0.05）.The incidence rates of nausea and vomiting in group J and group T were lower than that in group D at 6-15，16-30 and 31-50min after medication（P＜0.05）.The incidence rates of nausea and vomiting in group T were lower than that in group J（P＜0.05）.One case of suspected extrapyramidal reaction occurred in group J，and no adverse reactions occurred in other groups.Conclusion Dexamethasone+Metoclopramide+Tropisetron combined use has definite effect in preventing nausea and vomiting during cesarean section，which is worthy of further clinical research and application.

Key words： Dexamethasone Metoclopramide Tropisetron Cesarean section Carprost tromethamine

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	ZHANG Pei-cai
	LI Miao
	XU Hui-xia

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ZHANG Pei-cai,LI Miao,XU Hui-xia. Effect of Dexamethasone, Metoclopramide and Tropisetron on prevention of nausea and vomiting induced by Carboprost Tromethamine during cesarean section[J]. 中国当代医药, 2020, 27(4): 173-176.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I4/173

[1]	李艳.卡前列素氨丁三醇注射液在宫缩乏力性产后出血治疗中的应用效果分析[J].名医，2018，11：216.
[2]	邓雪云.针刺联合托烷司琼治疗剖宫产术中卡前列素氨丁三醇诱发恶心呕吐的效果[J].内蒙古中医药，2018，37（10）：81-82.
[3]	谭森，李影，臧晓党，等.盐酸戊乙奎醚联合地塞米松、托烷司琼预防剖宫产术中卡前列素氨丁三醇引发不良反应的效果观察[J].中国计划生育和妇产科，2018，10（11）：59-62.
[4]	张光焕.卡前列素氨丁三醇治疗乏力性产后出血对患者治疗效果及出血量、不良反应的影响[J].海峡药学，2018，30（11）：161-162.
[5]	杨春荣，张雅，王剑鹰，等.卡前列素氨丁三醇治疗对胎儿娩出后瘢痕子宫阴道分娩产妇产后出血量、产程时间及不良反应的影响[J].中国妇幼保健，2018，33（13）：2919-2922.
[6]	唐立东，郭阿梅.盐酸帕洛诺司琼注射液治疗剖宫产术中卡前列素氨丁三醇诱发恶心呕吐的效果观察[J].中国医药科学，2018，8（17）：157-159.
[7]	李影，谭森，臧晓党，等.咪达唑仑与昂丹司琼减少剖宫产术中卡前列素氨丁三醇所致不良反应的对比观察[J].中国计划生育和妇产科，2018，10（9）：55-58.
[8]	李海英，王燕，刘海.小剂量右美托咪定与丙泊酚预防卡前列素氨丁三醇诱发剖宫产术患者不良反应的效果对比[J].临床和实验医学杂志，2015，14（13）：1130-1133.
[9]	俞裕灵，王小虎.昂丹司琼预防治疗卡前列素氨丁三醇所致恶心呕吐的临床观察[J].中国现代医药杂志，2013，15（11）：29-31.
[10]	Talebpour M，Ghiasnejad ON，Imani F，et al.Comparison Effect of Promethazine/Dexamethasone and Metoclopramide/Dexamethasone on Postoperative Nausea and Vomiting after Laparascopic Gastric Placation：A Randomized Clinical Trial[J].Anesth Pain Med，2017，7（4）：e57810.
[11]	Sanaati F，Najafi S，Kashaninia Z，et al.Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer[J].Asian Pac J Cancer Prev，2016，17（8）：4125-4129.
[12]	Totadri，Sidharth.Prophylaxis and management of antineoplastic drug induced nausea and vomiting in children with cancer[J].Pediat Hematol Oncol J，2016，1（3）：50-55.
[13]	焦烨，许军.地塞米松联合托烷司琼预防剖宫产术后恶心呕吐的临床研究[J].临床和实验医学杂志，2017，16（24）：2466-2468.
[14]	李棽丽，段力仁，李洋，等.甲强龙和地塞米松预防剖宫产术后恶心呕吐的疗效对比分析[J].实用药物与临床，2017，20（7）：755-758.
[15]	王敏，姚建蓉，杨帆，等.地塞米松预防剖宫产术后采用阿片类药物镇痛所致恶心呕吐的Meta分析[J].中国循证医学杂志，2016，16（8）：933-938.
[16]	李新根，张慧堂.联合用药预防剖宫产后行自控硬膜外镇痛患者术后恶心呕吐的疗效观察[J].中国医师进修杂志，2016，39（Z1）：26-27.
[17]	张海罡，刘伟.地塞米松复合罗哌卡因腹横筋膜阻滞在剖宫产术后切口疼痛的镇痛效果观察[J].陕西医学杂志，2017，46（4）：432-434.
[18]	魏艳玲，刘芳，杨敏.地佐辛联合糖皮质激素对剖宫产术后镇痛及康复时间的影响[J].中国妇幼健康研究，2017，28（10）：1245-1247.