帕金森病患者嗅觉功能减退与疾病分期、运动障碍的相关性

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (0 KB) HTML (32 KB)
Export: BibTeX | EndNote (RIS)

Abstract [Abstract]Objective To investigate the correlation of olfactory dysfunction with disease stage and dyskinesia of Parkinson′s disease.Methods A total of 50 patients with Parkinson′s disease in our hospital from August 2016 to August 2018 were randomly selected as the Parkinson′s disease group，and 50 health check-ups in our hospital during the same period were randomly selected as the healthy control group.The olfactory recognition threshold（IT）and olfactory perception threshold（DT）of the two groups were detected by five-scent olfaction test solution in a non-odor，ventilated and quiet environment.Then the DT and IT，5 odorants loss of smell in the two groups were analyzed statistically，the correlation between Parkinson′s disease score scale（UPDRS）score and olfactory function of patients with Parkinson′s disease were analyzed.Results The DT and IT of patients with stage 1，1.5，2，2.5 and 3 in the Parkinson′s disease group were higher than the healthy control group（P＜0.05）.The DT and IT of acid，banana，mint，flower fragrance and stench of the Parkinson′s disease group were higher than the healthy control group（P＜0.05）.There were no correlations between UPDRS score，motor function score，DT and IT of patients with Parkinson′s disease（P＞0.05）.The rates of acid，banana，mint，flower fragrance and odor loss of smell of the Parkinson′s disease group（12.0% [6/50]，34.0% [17/50]，46.0% [23/50]，34.0% [17/50]，52.0% [26/50]）were higher than the healthy control group（0.0% [0/50]，2.0% [1/50]，4.0% [2/50]，0.0% [0/50]，2.0% [1/50]）（P＜0.05）.Conclusion The degrees of olfactory dysfunction in Parkinson′s disease patients with different disease stages and dyskinesia are higher than healthy people，however，olfactory dysfunction in patients with Parkinson′s disease has no correlation with disease stage and dyskinesia.

Key words： Parkinson′s disease Olfactory dysfunction Stage of disease Dyskinesia Correlation

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I4/63

[1]	蔡谋善，吴琼，陈凤仪.帕金森病患者的嗅觉功能、嗅球体积、嗅沟深度变化及诊断价值[J].临床和实验医学杂志，2019，18（3）：293-295.
[2]	尹苗苗，张玥，于洋，等.帕金森病非运动症状的运动治疗研究进展[J].中华物理医学与康复杂志，2018，40（10）：798-800.
[3]	李建平，阮红芳，段阳日.芪芍益肾平肝方对左旋多巴治疗帕金森病患者的协同作用[J].中国中医药科技，2018，25（5）：751-752.
[4]	王瑞丹，李丹凝，左丽君，等.帕金森病伴发嗅觉障碍及其与临床症状的关系[J].中国神经免疫学和神经病学杂志，2018，25（5）：321-326.
[5]	王丹，李沛珊，李艳霞，等.ATP13A2基因与帕金森病的研究进展[J].新疆医学，2018，48（5）：478-483.
[6]	吴宇瑶，吴锦.帕金森病与强制性运动疗法[J].神经病学与神经康复学杂志，2018，14（2）：106-110.
[7]	胡盼盼，冯果，陈先文，等.嗅觉识别测验在帕金森病患者中的应用[J].中华神经科杂志，2016，49（8）：610-614.
[8]	郑赟赟，张文波，严芳，等.嗅觉功能及嗅球体积联合检测对PD的诊断价值研究[J].中华神经医学杂志，2017，16（8）：810-815.
[9]	李雪，迟景宏，辛世萌.帕金森病患者日间过度思睡[J].神经疾病与精神卫生，2017，17（10）：754-757.
[10]	朱骏，潘杨，沈柏，等.帕金森病患者嗅觉减退的相关因素分析[J].卒中与神经疾病，2016，23（2）：102-106.
[11]	Yan YY，Lei K，Li YY，et al.The correlation between possible RBD and cognitive function in Parkinson′s disease patients in China[J].Ann Clin Transl Neurol，2019，6（5）：848-853.
[12]	Kaur P，Sharma M.Diagnosis of human psychological disorders using supervised learning and nature-inspired computing techniques：A Meta-analysis[J].J Med Syst，2019，43（7）：204.
[13]	Dai D，Yuan J，Wang Y，et al.Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation[J].Sci Rep，2019，9（1）：8034.
[14]	Zekaj E，Saleh C，Servello D.Hydrocephalus after deep brain stimulation for Parkinson′s disease[J].Asian J Neurosurg，2019，14（2）：538-540.
[15]	Doaee P，Rajaei Z，Roghani M，et al.Effects of Boswellia serrata resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson′s disease[J].Avicenna J Phytomed，2019，9（3）：281-290.
[16]	Boutet A，Gramer R，Steele CJ，et al.Neuroimaging technological advancements for targeting in functional neurosurgery[J].Curr Neurol Neurosci Rep，2019，19（7）：42.
[17]	Xu M，Zhang S，Zhao H，et al.Association between nucleotide-binding oligomerization domain protein 2（NOD2）gene polymorphisms and Parkinson′s disease（PD）susceptibility[J].Artif Cells Nanomed Biotechnol，2019，47（1）：2134-2138.
[18]	Young G.A review of a patient with Parkinson′s disease in general practice[J].Rev Infirm，2019，68（250）：45-46.