重组人粒细胞刺激因子联合VDLP方案治疗费城染色体阴性急性淋巴细胞白血病患者的临床效果

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Abstract [Abstract]Objective To study the clinical effect of Recombinant Human Granulocyte Stimulating Factor combined with VDLP regimen in the treatment of patients with Philadelphia chromosome-negative acute lymphoblastic leukemia（ALL）.Methods A total of 60 patients with Philadelphia chromosome-negative ALL admitted to the the First People′s Hospital of Zhaoqing and General Hospital of Pingmei Shenma Medical Group from March 2014 to March 2018 were selected as the study subjects，and they were divided into the control group and the study group according to the random number table method，30 cases in each group.The control group was treated with VDLP regimen，and the study group was treated with Recombinant Human Granulocyte Stimulating Factor on the basis of the control group.The therapeutic effect，the absolute reduction time of white blood cells and neutrophils，the total incidence rate of adverse reactions and quality of life（GQOLI-74）score before and after treatment were compared between the two groups.Results The total remission rate in the study group（70.00% [21/30]）was higher than that in the control group（43.33% [13/30]），and the difference was statistically significant（P＜0.05）.The absolute reduction time of white blood cells and neutrophils in the study group was shorter than that in the control group，and the difference was statistically significant（P＜0.05）.The total incidence rate of adverse reactions in the study group（6.67% [2/30]）was lower than that in the control group（26.67% [8/30]），and the difference was statistically significant（P＜0.05）.After treatment，the psychological function，physical function，material life，and social function scores of the two groups were higher than those before treatment，and those in the study group were higher than those in the control group，with statistically significant differences（P＜0.05）.Conclusion Recombinant Human Granulocyte Stimulating Factor combined with VDLP regimen in the treatment of patients with Philadelphia chromosome-negative ALL can effectively improve the therapeutic effect，shorten the absolute reduction time of white blood cells and neutrophils，reduce the incidence rate of adverse reactions and improve the prognosis of patients.

Key words： Philadelphia chromosome-negative acute lymphoblastic leukemia VDLP regimen Recombinant Human Granulocyte Stimulating Factor Adverse reactions Quality of life

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