高密度脂蛋白亚型与心脑血管病发生风险相关性的Meta分析

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Abstract [Abstract]Objective To systematically evaluate the correlation between high-density lipoprotein（HDL）subfractions and the risk of cardio-cerebrovascular diseases.Methods The literatures related to the relationship between HDL subfractions and cardio-cerebrovascular diseases published on PubMed，Embase，Cochrane Library，China National Knowledge Infrastructure（CNKI），Wanfang Database and Chinese Biomedical Literature Database（CBM）from the establishment of the database to July 2019 were searched.The inclusion and exclusion criteria were strictly followed.The stata 12.0 and Review Manager 5.3 software were used for Meta-analysis.Results HDL particle（HDLp）（RR=0.82，95%CI[0.77，0.87]，P＜0.000 01）and its subfractions defined by nuclear magnetic resonance were shown superior correlation with cardio-cerebrovascular disease to HDL cholesterol（HDL-C）（RR=0.93，95%CI [0.87，1.00]，P=0.05）.Within each individual ending events，HDL-C（RR=0.96，95%CI [0.91，1.01]，P=0.16），HDLp（RR=0.97，95%CI [0.82，1.15]，P=0.74）and its subfractions showed no correlation with the incidence of stroke.No correlation was observed between coronary artery disease and HDL2（RR=0.95，95%CI [0.87，1.04]，P=0.27）or HDL3（RR=0.89，95%CI [0.79，1.01]，P=0.06）defined by ultracentrifugation.Conclusion HDLp and its subfractions defined by nuclear magnetic resonance are better indicators for risk of coronary artery diseases than HDL-C.There are no associations between HDL-C，HDLp and HDLp subfractions and stroke.HDL subfractions defined by ultracentrifugation are not good predictors of the risk of coronary artery diseases.

Key words： High-density lipoprotein subfractions Cardio-cerebrovascular diseases Coronary heart disease Stroke;Meta-analysis

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