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Quick Search     Adv Search 2021 Vol. 28, No. 10 Published: 2021-04-08   4 Intervention effect of Rhizoma Drynariae Total Flavone on osteoporosis in ovariectomized rats CHEN Xue-sheng; ZHANG Hong-qin;CHEN Qiu-qin; LIN Li; WANG Yong-sheng Objective To explore the intervention effect of Rhizoma Drynariae Total Flavone on osteoporosis (OP) in rats.Methods A total of 21 Sprague-Dulle (SD) rats were selected and divided into blank group, model group and treatment group according to the random number table method, with 7 rats in each group.The blank group was left untreated, ovariectomy-induced osteoporosis model was established in the model group, and the treatment group was administered with 0.054 g/(kg·d) Rhizoma Drynariae Total Flavone after model establishment.The bone mineral density(BMD) of the right femur was measured by the dual-energy X-ray absorptiometry.The expression levels of bone transformation markers osteocalcin (BGP), the bone alkaline phosphatase (BALP) and the thyroxine (PTH) in serum were detected by the enzyme-linked immunosorbent assay (ELISA), and the histopathological changes of bone hematoxylineosin (HE) staining were observed by microscope.Results Before the intervention, the BMD of the model group was lower than that of the blank group, with statistically significant difference (P＜0.05).There was no significant difference in BMD between the treatment group and the model group before the intervention (P＞0.05).After the intervention, the BMD of the blank group and the treatment group was higher than that of the model group, with statistically significant difference (P＜0.05).The BMD in the treatment group was lower than that in the blank group after the intervention, and the difference was statistically significant (P＜0.05).There was no statistically significant difference in BMD among the three groups before and after the intervention (P＞0.05).The HE staining showed that the number, density, layout and integrity of trabeculae in the femoral bone tissue of the treatment group were better than those of the model group.The ELISA results showed that the BGP in the model group was lower than that in the blank group, BALP and PTH were higher than those in the blank group, and the differences were statistically significant (P＜0.05).The BGP of the treatment group was lower than that of the blank group, BALP and PTH were higher than those of the blank group, and the differences were statistically significant (P＜0.05).The BGP of the treatment group was higher than that of the model group, BALP and PTH were lower than those of the model group, and the differences were statistically significant (P＜0.05).Conclusion The Rhizoma Drynariae Total Flavone intervention has a good effect on the OP induced by castration. 2021 Vol. 28 (10): 4-7 [Abstract] ( 40 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 8 Diagnosis essentials of atelectasis of pediatric Mycoplasma pneumoniae CHEN Qiong-hua; ZHENG Jing-yang;CHEN Tian-feng; LIN Chun-yan; LIN Yin-tao; LIN Yang-sheng Objective To investigate the clinical diagnostic essentials of atelectasis of pediatric Mycoplasma pneumoniae and raise awareness of the disease.Methods Retrospective analysis was performed on 672 cases of Mycoplasma pneumoniae pneumonia who were admitted in Department of Respiratory, Quanzhou Children′s Hospital from January 2019 to April 2020 which were divided into atelectasis group and normal group according to the lung image, 336 cases in each group.The clinical indexes of the two groups were compared, Logistic regression analysis was used to count the risk factors of atelectasis, and the ROC curve was drawn to find the reference cut-off value of atelectasis.Results The fever, wet rales and pleural effusion in the atelectasis group were more than those in the control group, and the history of allergy and wheezing in the atelectasis group were less than those in the control group, the differences were statistically significant (P＜0.05).Heat course, neutrophil proportion, C-reaction protein (CRP), lactic dehydrogenase (LDH)and DNA damage and repair (DDR) in the atelectasis group were higher than those in the control group, and the differences were statistically significant (P＜0.05).ROC curve showed that fever duration≥2.5 d, neutrophil ratio≥50.7%,CRP≥14.04 mg/L, DDR≥0.51 mg/L, LDH≥345.5 U/L, which were helpful for the diagnosis of atelectasis.Conclusion Children with Mycoplasma pneumoniae pneumonia with heat course longer than 2.5 d, lack of allergic history,presence of wet rales, neutrophils proportion, CRP, LDH, DDR above the critical values should pay attention to complicated with atelectasis. 2021 Vol. 28 (10): 8-11 [Abstract] ( 42 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 12 Risk factors for hospital acquired pneumonia in elderly patients with hypertensive intracerebral hemorrhage HE Sen；WEI Ming-li；XIE Fei；XUE Fang；HAO Jian-qiang；ZHANG Yuan-jun Objective To investigate the risk factors of hospital acquired pneumonia (HAP) in elderly patients with hypertensive intracerebral hemorrhage (HICH).Methods Clinical data of 137 elderly patients with HICH admitted to the First People′s Hospital of Ziyang City from January 2017 to December 2019 were retrospectively analyzed, including basic information, infection status and microbiological test results.Risk factors for HAP and characteristics of common pathogens were analyzed.Results Among 137 elderly patients with HICH, 85 cases were complicated with HAP, the incidence was 62.04%.A total of 116 strains of pathogens were isolated, including 88 strains (75.86%) of Gram-negative bacteria，24 strains (20.69%) Gram-positive bacteria and 4 strains (3.45%) of fungi were detected.Single factor analysis showed that there were significant differences in age ≥80 years old, history of chronic pulmonary disease, diabetes mellitus，vomited, glasgow coma scale (GCS) score ≤8 points at admission, nasal feeding, trachea interventional therapy, hypoproteinemia, use of corticosteroids and proton pump inhibitors (PPI), for HAP or not in elderly patients with HICH (P＜0.05).Multivariate analysis showed that age ≥80 years old (β=2.39, OR=9.71, 95%CI 9.12-10.35), history of chronic pulmonary disease (β=2.46, OR=10.65, 95%CI 9.45-11.11), diabetes mellitus (β=1.93, OR=2.57, 95%CI 1.55-5.93), vomited after onset (β=1.67, OR=5.13, 95%CI 2.11-10.52), at admission GCS score ≤8 points (β=2.25, OR=8.89, 95%CI 8.27-9.39), nasal feeding (β=1.21, OR=3.19, 95%CI 1.51-7.01), trachea interventional therapy(β=2.73, OR=14.61, 95%CI 14.16-15.62), hypoproteinemia (β=1.13, OR=2.91, 95%CI 1.20-6.03), use of Corticosteroids (β=0.47, OR=1.52, 95%CI 1.15-4.12) and PPI (β=0.52, OR=1.63, 95%CI 1.29-2.54) were independent risk factors for HAP in elderly patients with HICH (P＜0.05).Conclusion There are many risk factors and high incidence of HAP in elderly patients with HICH.Therefore, individualized prevention and treatment programs should be formulated according to the risk factors to reduce the incidence of HAP. 2021 Vol. 28 (10): 12-15转19 [Abstract] ( 44 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 16 Analysis of risk factors of central venous catheter infection in maintenance hemodialysis ZHANG Lin Objective To explore the risk factors of central venous catheter infection in maintenance hemodialysis.Methods A total of 200 cases of maintenance hemodialysis patients with central venous catheter in the Fifth People′s Hospital of Shenyang from January 2018 to June 2020 were selected as the research objects, and the clinical data of patients were retrospectively analyzed.The incidence of central venous catheter infection and the distribution of infection strains were recorded.The risk factors of central venous catheter infection in maintenance hemodialysis were analyzed.Results Among 200 patients, the incidence of maintenance hemodialysis complicated with central venous catheter infection was 11.50%.A total of 19 strains were detected, among which gram-negative bacteria accounted for 57.89%, gram-positive bacteria accounted for 31.58%, and fungi accounted for 10.53%.The results of univariate analysis showed that there were no significant differences in gender and hypertension between the infected and uninfected groups (P＞0.05).Comparison of age, catheterization site, puncture times, catheterization time, diabetes mellitus and anemia between the two groups, the differences were statistically significant (P＜0.05).Multivariate analysis revealed＞60 years old（β=6.229, OR=1.276, 95%CI=1.027-1.495）, femoral vein catheterization (β=6.293, OR=1.498, 95%CI=1.142-1.832), number of punctures≥3 (β=5.852, OR=1.347, 95%CI=1.016-1.416), catheterization time ≥14 d (β=6.173, OR=1.132, 95%CI=1.045-1.521), with diabetes (β=5.982, OR=1.762, 95%CI=1.114-1.895), and with anemia (β=5.734, OR=1.358, 95%CI=1.126-1.573) were independent risk factors (P＜0.05).Conclusion The risk factors of central venous catheter infection in maintenance hemodialysis include older age, femoral vein catheterization, more times of puncture, longer catheterization duration, and combined with diabetes mellitus, anemia and other basic diseases.Therefore, targeted nursing should be carried out for these risk factors in order to reduce the incidence of infection. 2021 Vol. 28 (10): 16-19 [Abstract] ( 42 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 20 Meta-analysis of the efficacy of Chaishao Liujunzi Decoction combined with transarterial chemoembolization in the treatment of primary liver cancer QIU Han-bo； ZHAO Yi-man；ZHOU Yao-hong； ZHENG Jing-hui；PENG Qi-long；HOU En-cun Objective To systematically evaluate the efficacy of Chaishao Liujunzi Decoction combined with transarterial chemoembolization (TACE) in the treatment of primary liver cancer.Methods The Chinese and English literature databases were searched by computer, and randomized controlled studies (RCTs) of Chaishao Liujunzi Decoction combined with TACE (experimental group) and TACE (control group) on patients with advanced primary liver cancer were searched.The retrieval time was from the time of building the repository to November 30, 2019.RevMan 5.3 software was used for Meta-analysis.Results The Meta-analysis showed that the Karnofsky performance status (KPS) score of the experimental group was higher than that of the control group (MD=9.43, 95%CI=6.59-12.27, P＜0.000 01), the increase of bilirubin was lower than that of the control group(RR=0.48,95%CI=0.31-0.74,P=0.001),the nausea and vomiting was lower than that of the control group(RR=0.54,95%CI=0.31-0.94,P=0.03),the abdominal pain was lower than that of the control group (RR=0.56, 95%CI=0.40-0.79, P=0.001), and the fever was lower than that of the control group (RR=0.60, 95%CI=0.42-0.85, P=0.005), and the differences were statistically significant.There were no significant differences in solid tumor control (RR=1.04, 95%CI=0.93-1.17, P=0.48), leukopenia (RR=0.76, 95%CI=0.48-1.20, P=0.24)and thrombocytopenia (RR=0.81, 95%CI=0.52-1.24, P=0.32) between the two groups.Conclusion Chaishao Liujunzi Decoction combined with TACE can significantly improve KPS score and reduce the occurrence of adverse reactions to chemotherapy. 2021 Vol. 28 (10): 20-22转27 [Abstract] ( 49 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 23 Correlation between serum homocysteine level and atrial fibrillation in elderly patients with acute cerebral infarction ZHENG Jing-xuan； LIN Jin-guang； CHEN Zhi-qiang ；WEN Xue； LIN Tao Objective To analyze the correlation between serum homocysteine (Hcy) level and atrial fibrillation (AF) in elderly patients with acute cerebral infarction (ACI).Methods A total of 120 elderly ACI patients admitted to Yangjiang People′s Hospital from March 2017 to February 2020 were selected as the experimental group, and 120 healthy participants who received physical examinations in the same period were randomly selected as the reference group.The serum Hcy levels of the experimental group and the reference group were detected and compared.Patients in the experimental group were divided into the elderly ACI group (n=72) and the elderly ACI with AF group (n=48)according to whether patients with AF were complicated.Serum Hcy levels of the elderly ACI group and the elderly ACI with AF group were compared.According to the classification of cardiac function, the patients in the experimental group were divided into cardiac function level Ⅱgroup (32 cases), cardiac function level Ⅲgroup (48 cases), cardiac function level Ⅳgroup (40 cases), and the serum Hcy levels in different cardiac function groups were compared.Patients in the experimental group were divided into permanent AF group (8 cases), persistent AF group (21 cases) and paroxysmal AF group (19 cases) according to AF criteria.Serum Hcy levels in different degrees of AF groups were compared.The correlation between serum Hcy level and elderly ACI with AF was analyzed using Pearson correlation.Results The serum Hcy level in the experimental group was higher than that in the reference group, and the difference was statistically significant (P＜0.05).Serum Hcy level of elderly patients in ACI with AF group was higher than that in elderly ACI group, and the difference was statistically significant (P＜0.05).Serum Hcy level of cardiac function levelⅣgroup was higher than that in the cardiac function level Ⅲgroup and cardiac function level Ⅱgroup, the differences were statistically significant (P＜0.05).The serum Hcy level in the permanent AF group was higher than that in the persistent AF group and the paroxysmal AF group, and the serum Hcy level in the persistent AF group was higher than that in the paroxysmal AF group, the differences were statistically significant (P＜0.05).The results of Pearson correlation analysis showed that the serum Hcy level was positively correlated with the elderly ACI combined with AF (r=0.684, P=0.037).Conclusion The serum Hcy level in elderly patients with ACI is positively correlated with the severity of AF.As AF changes from paroxysmal to permanent, the serum Hcy level will gradually increase. 2021 Vol. 28 (10): 23-27 [Abstract] ( 47 ) HTML (43 KB)  PDF  (0 KB)  ( 7 ) 28 Research progress on targeted therapy of Kirsten rat sarcoma virus oncogene mutation in non-small cell lung cancer DAI Nan-li； XIANG Ming-jun；DU Wei； XIAO Ze-min Kirsten rat sarcoma viral oncogene (KRAS) mutation is one of the most common driver gene mutations in non-small cell lung cancer.Although KRAS mutation was discovered decades ago,target therapy of non-small cells with KRAS mutations has been a bottleneck due to their unique biological characteristics.However, the emergence of new KRAS G12C inhibitors broke this deadlock and further developed targeted therapy for non-small cell lung cancer with mutations in the KRAS gene.The research mechanism of targeting KRAS mutant non-small cell lung cancer at home and abroad is mainly to inhibit membrane localization, directly inhibit KRAS gene, target inhibition of KRAS downstream signals, and inhibit KRAS mutation co-lethal genes.This review summarizes the research progress of targeted therapy for non-small cell lung cancer with mutations in the KRAS gene, so that clinicians can have a deeper understanding of targeted therapy for this particular type of non-small cell lung cancer. 2021 Vol. 28 (10): 28-31转39 [Abstract] ( 47 ) HTML (45 KB)  PDF  (0 KB)  ( 7 ) 32 Analysis of the status quo of Chinese patent medicine in pediatrics YE Qing-yun ；ZHANG Yi Chinese patent medicine has been widely used in the treatment of pediatric diseases because of its unique advantages of "simplicity, efficiency and inefficiency", and has been favored by the majority of patients and their families.However, due to the few types of special drugs, the difficulties in drug research and development, the incomplete label, the non-standard application of clinicians, the lack of traditional Chinese medicine clinical pharmacists and other problems, lead to the use of proprietary Chinese medicine is not standard, unreasonable, unsafe problems prominent.Therefore, this paper suggests to explore the rational and standardized use of Chinese patent medicines in pediatrics from four aspects: policy support, standardized drug instructions, standardized prescribing by physicians, and play the role of traditional Chinese medicine clinical pharmacists, so as to ensure the safety of drug use in children. 2021 Vol. 28 (10): 32-35 [Abstract] ( 45 ) HTML (41 KB)  PDF  (0 KB)  ( 8 ) 36 Research progress of biomarkers in early diagnosis of diabetic nephropathy JI Chao；SONG Yu-ling； LIU Chang-mei Diabetic nephropathy (DN), defined as urinary albumin excretion rate (UAER) >300 mg/24 h and declining renal function in a patient with known diabetes mellitus (DM) in the absence of urinary tract infection or any other renal diseases.DN is a common microvascular complication of DM.Searching for biomarkers with high sensitivity and specificity is helpful for early diagnosis and treatment of DN to improve the prognosis of patients.In order to provide researchers with the current research status of DN, this paper will summarize and discuss the research progress of biomarkers in the early diagnosis of DN based on glomerular and tubular injury, oxidative stress, inflammation and proteomics, hoping that biomarkers can be used in clinical work as soon as possible. 2021 Vol. 28 (10): 36-39 [Abstract] ( 47 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 40 Research progress on the effect of different glaucoma surgical treatments on corneal nerve HUO Meng-meng;GAO Xue;ZONG Hui;ZHANG Yuan-yuan;JIANG Xiao-hui Glaucoma is one of the main causes of blindness.The ganglion cell axons that make up the optic nerve are damaged by a variety of factors.The mechanism is not completely clear, and there are many treatment methods.The various surgical methods for glaucoma will affect the shape and function of the corneal nerve to varying degrees due to the difference in the location, scope, and depth of the incision.The corneal nerve is an important structure of the ocular surface, and it plays an important role in maintaining the normal structure and function.The loss of normal corneal nerves will cause malnutrition and metabolic disorders of the cornea.Corneal sensation affects wound healing and surgical quality when it decreases or disappears after nerve injury.Therefore, it is necessary to understand the process and influencing factors of corneal nerve injury so as to improve the surgical treatment effect. 2021 Vol. 28 (10): 40-43 [Abstract] ( 48 ) HTML (37 KB)  PDF  (0 KB)  ( 4 ) 44 Research progress in the treatment of behavioral and psychological symptoms in dementia patients DONG Meng； LUO Hai-yan Almost more than 90% people with dementia suffer from behavioral and psychological symptoms, whose clinical types are varied, and the pathogenesis involved is not clear.Therefore, the treatment and management of neuropsychiatric signs and symptoms in dementia patients are still difficult.In recent years, there have been some new theoretical progress in the behavioral and psychological symptoms of dementia, which has further enhanced the status of non-pharmacologic intervention in treatment.Many domestic and foreign guidelines have recommended non-pharmacologic intervention as the first line, and pharmacologic therapy as an important complementary means.It′s better to make individual treatment program for dementia patients with behavioral and psychological symptoms.This paper will elaborate the research progress of non-pharmacologic intervention and pharmacologic therapy, focusing on how to refine the non-pharmacologic intervention therapy and select the corresponding pharmacologic therapy according to the patients′situation. 2021 Vol. 28 (10): 44-47转53 [Abstract] ( 38 ) HTML (42 KB)  PDF  (0 KB)  ( 7 ) 48 Pre-treatment method for clinical detection of respiratory virus samples FANG Zhi-xin； GU Hong-qin；SHi Mei-fang； LIN Yong Respiratory virus infection is one of the main causes of common respiratory diseases.This article aims to summarize and discuss the elements of quality control of the pre-processing of respiratory virus samples, and to provide reference and guidance for clinical respiratory virus sample pre-processing programs.The main points of the quality control on the pretreatment of respiratory virus clinical testing are reviewed in this essay, including 4 main aspects-the type of specimen, collection, transportation and storage.According to the analysis, the applicable conditions of various types of specimens and swab materials, as well as the requirements for the collection, transportation and storage of respiratory virus samples, are obtained.Among them, nasopharyngeal swab specimens are the key specimen types.At present, in the selection of specimen types for respiratory virus samples, nasopharyngeal swab is the best sample type.Multiple types of specimens can also be used in combination.For example, nasopharyngeal swab and oropharyngeal swabs, saliva specimens, and sputum specimens can improve the sensitivity and accuracy of detection.To the actual clinical situation, it has certain value.In addition, this article also explains the possibility of new specimen types being put into clinical testing. 2021 Vol. 28 (10): 48-53 [Abstract] ( 43 ) HTML (49 KB)  PDF  (0 KB)  ( 8 ) 54 Clinical study of HHHFNC to prevent neonatal extubation failure TAO Li； CHEN Li-ping； YAN Chang-hong Objective To explore the effect of heated humidified high flow nasal canula ventilation (HHHFNC) on preventing neonatal extubation failure.Methods From June 2016 to June 2019, a total of 211 children in Neonatal Intensive Care Unit (NICU) of Jiangxi Provincial Children′s Hospital who needed non-invasive assisted ventilation after tracheal intubation were selected as subjects.According to the random number table method, they were divided into nasal continuous positive airway pressure ventilation (NCPAP) group (n=102) and HHHFNC group (n=109).The two groups of children were compared with the average airway pressure (MAP) before extubation, the inhaled oxygen concentration before extubation (FiO2), the application time of the invasive ventilator, total number of oxygen days and other respiratory parameters, the failure of extubation and the occurrence of complications.Results There were no significant differences between the two groups of children before extubation MAP and invasive ventilator application time, FiO2 concentration before extubation and other respiratory parameters, the differences were not statistically significant (P＞0.05).Total number of oxygen days of HHHFNC group was shorter than that in NCPAP group, the difference was statistical significance (P＜0.05).There was no significant difference in the extubation failure rate between the two groups (P＞0.05).The incidence of adverse events (nosocomial infection, chronic lung disease) and complications (abdominal distension,nasal injury) of children in the HHHFNC group were lower than those in the NCPAP group, the differences were statistically significant (P＜0.05).Conclusion Compared with the NCPAP method, the application of HHHFNC can effectively shorten the total number of days of oxygen use in children and reduce complications and adverse reactions, and is more meaningful in preventing neonatal extubation failure. 2021 Vol. 28 (10): 54-56 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 57 Clinical effect of Anlotinib anti-angiogenesis combined with radiotherapy and chemotherapy in the treatment of middle-advanced non-small cell lung cancer LI Zhen-bin；CHEN Xuan； YI Wu-qiang； TANG Xiao-mei；ZHANG Li；YI Xiang-jun Objective To investigate the clinical effect of antiangiogenesis with Anlotinib combined with radiotherapy and chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC).Methods A total of 80 patients with advanced NSCLC admitted to Jiangxi Chest Hospital from January 2019 to May 2020 were selected as the research subjects, and they were divided into group A, B, C and D according to random number table method, with 20 patients in each group.Group A was treated with Anlotinib anti-angiogenesis+chemoradiotherapy, group B was treated with Anlotinib anti-angiogenesis+radiotherapy, group C was treated with Anlotinib anti-angiogenesis+chemotherapy, and group D was treated with chemotherapy alone.The remission rate, the incidence of adverse reactions of the four groups were compared.Results The remission rate of group A was higher than those of group B, C and D, and the differences were statistically significant (P＜0.05).There was no significant difference in the remission rate among B, C and D groups (P＞0.05).There were no significant differences in the incidence of fever, fatigue, nausea and vomiting, bone marrow suppression and radiation pneumonia among the four groups (P＞0.05).Conclusion Anlotinib anti-angiogenesis combined with radiotherapy and chemotherapy can improve the local tumor control effect of patients with middle-advanced NSCLC, and it has high safety and is worthy of promotion. 2021 Vol. 28 (10): 57-59转66 [Abstract] ( 52 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 60 Effect of cortisol administration before biopsy on the pathologic diagnosis of primary central nervous system lymphoma ZHANG Yan； HU Bin；SONG Chuan-fang； LI Li； LI Hua-min Objective To investigate the effect of cortisol administration before biopsy on the pathologic diagnosis of primary central nervous system lymphoma.Methods The clinical data of 180 patients with primary central nervous system lymphoma treated in Hongqi Hospital Affiliated to Mudanjiang Medical College from August 2017 to October 2019 were retrospectively analyzed.According to whether or not cortisol was used, the patients were divided into the preoperative cortisol group (91 cases) and the non-preoperative cortisol group (89 cases), and the pathological diagnosis results of the two groups were compared.Results In the preoperative corticosterol group, 5 cases (5.49%) did not get positive results, and primary central nervous system lymphoma was confirmed after re-biopsy.In the preoperative non cortisol-treated group, 3 cases (3.37%) did not get positive results, and primary central nervous system lymphoma was confirmed after re-biopsy.There was no significant difference in case detection results between the two groups (P>0.05).Conclusion For most patients with primary central nervous system lymphoma, the application of cortisol before biopsy has no significant impact on the final pathological diagnosis. 2021 Vol. 28 (10): 60-62转70 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 63 Analysis of the relationship between heart failure and B-type brain natriuretic peptide in patients with hemodialysis LIU Yan-li ；CHEN Qing-ping Objective To analyze the relationship between heart failure (HF) and B-type brain natriuretic peptide(BNP) in patients with hemodialysis.Methods From January 2019 to August 2020, a total of 60 new found of patients with hemodialysis in Pingxiang People′s Hospital were selected, according to the left ventricular ejection fraction(LVEF) levels, patients with HF (LVEF＜50%) were classified as the observation group (30 cases), and those without HF(LVEF≥50%) were classified as the control group (30 cases).Both groups were tested for LVEF, BNP levels after admission,the observation group was received conventional anti-HF treatment and integrated treatment of chronic renal failure,and the control group was received conventional hemodialysis and integrated treatment of chronic kidney disease.LVEF levels of the two groups at admission were recorded; the BNP levels of the two groups at admission and after intervention treatment were compared.The relationship between LVEF and BNP levels in patients with hemodialysis were analyzed,and a receiver operating curve(ROC)curve was drawn to analyze the predictive value of BNP levels for HF in patients with hemodialysis.Results LVEF level of observation group at admission was lower than that of control group, the difference was statistically significant(P＜0.05);the BNP levels of observation group at admission and after treatment were higher than those of control group, and the BNP level of the observation group after treatment was lower than that at admission, the differences were statistically significant (P＜0.05); the BNP level after treatment in the control group was compared with that at admission, the difference was not statistically significant (P＞0.05).Correlation analysis showed that LVEF level was negatively correlated with BNP level at admission (r=-0.806，P＜0.001).The ROC curve was drawn and analyzed that the BNP level predicted the area under the curve of HF in patients with hemodialysis was 0.952,which had high predictive value, the corresponding optimal threshold was 222.35 ng/dL, the sensitivity was 96.70%,and the specificity was 46.70%.Conclusion The level of BNP can effectively judge the progress of HF in patients with hemodialysis.High level of BNP is an influencing factor of HF in patients with hemodialysis.Clinical interventions can be made in advance based on the level of BNP to improve the prognosis of patients.It is worthy of clinical promotion. 2021 Vol. 28 (10): 63-66 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 67 Effect of Budesonide Fomoterol combined with pulmonary rehabilitation training on pulmonary function and improvement of quality of life in patients with moderate-severe chronic obstructive pulmonary disease in stable phase ZHU Cai-liang Objective To investigate the effect of Budesonide Formoterol combined with pulmonary rehabilitation training on lung function and quality of life in moderate to severe chronic obstructive pulmonary disease (COPD) patients at stable stage.Methods A total of 86 patients with moderate and severe COPD who were treated in the Second People′s Hospital of Nankang District in Ganzhou City from July 2017 to December 2019 were selected as the research subjects.According to random number table method,they were divided into control group(43 cases)and observation group(43 cases).The control group was treated with Budesonide Formoterol, and the observation group was treated with pulmonary rehabilitation training on the basis of the control group.Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), 6-min walking distance, quality of life score and acute attack rate were compared between the two groups.Results After treatment, the FVC and FEV1 of the observation group were (2.89±0.41) and (2.03±0.35) L, which were higher than those of the control group (2.57±0.38) and (1.81±0.31) L, the differences were statistically significant (P＜0.05).After treatment, the 6 min walking distance of the observation group was (364.78±25.65) m, longer than that of the control group of (324.14±23.59) m, and the difference was statistically significant (P＜0.05).After treatment, COPD assessment test (CAT) score and modified British medical research council dyspnea index (mMRC) score in the observation group were (14.39±2.42) and (1.59±0.22)points, lower than those in the control group of (18.93±2.56) and (1.81±0.25) points, the differences were statistically significant (P＜0.05).The acute attack rate of the observation group was 4.65%, lower than that of the control group (18.60%), the difference was statistically significant (P＜0.05).Conclusion Budesonide Formoterol combined with pulmonary rehabilitation training can enhance lung function,reduce the number of acute attacks and improve the quality of life in patients with moderate to severe COPD. 2021 Vol. 28 (10): 67-70 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 71 Study on the predictive value of IL-6 and TNF-α in the severity of druginduced liver injury TAN Li-juan； XU Pei-yan；LI li Objective To explore the clinical value of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)levels in the prediction of drug-induced liver injury severity.Methods A total of 61 patients with drug-induced liver injury in Guangzhou Huadu District People′s Hospital from May 2018 to December 2019 were collected as research subjects.According to the severity of liver injury, the patients were divided into mild liver injury group (n=30), moderate liver injury group (n=24) and severe liver injury group (n=7).Another 35 cases of healthy people in the same period were selected as the normal control group.The serum levels of IL-6 and TNF-α were detected by double antibody sandwich enzyme-linked immunosorbent assay.Results Before treatment, the levels of serum IL-6 and TNF- α in mild liver injury group, moderate liver injury group and severe liver injury group were higher than those in the normal control group, the differences were statistically significant(P＜0.05).With the aggravation of liver injury, the levels of serum IL-6 and TNF-α increased gradually, the differences among the groups were statistically significant (P＜0.05).After 3 days of treatment, the levels of serum IL-6 and TNF-α in mild liver injury group, moderate liver injury group and severe liver injury group were lower than those before treatment, the differences were statistically significant(P＜0.05).After 2 weeks of treatment, the levels of IL-6, TNF-α and glutamic oxalacetic transamindse (AST) in the effective group were lower than those in the ineffective group, the differences were statistically significant (P＜0.05). Pearson correlation analysis showed that the levels of IL-6 and TNF-α in patients with drug-induced liver injury were positively correlated with AST and alanine transaminase (ALT) before treatment (P＜0.05).Conclusion Serum IL-6 and TNF-α can be used to predict the severity and prognosis of drug-induced liver injury,and have high clinical value. 2021 Vol. 28 (10): 71-74 [Abstract] ( 46 ) HTML (41 KB)  PDF  (0 KB)  ( 9 ) 75 Application of rehabilitation training combined with intermittent oral to esophageal feeding in stroke patients with dysphagia HUA Wen-ying Objective To explore the effect of rehabilitation training combined with intermittent oral to esophageal feeding in stroke patients with dysphagia.Methods A total of 60 patients with stroke and dysphagia who were admitted to the First People′s Hospital of Fuzhou City from June 2019 to June 2020 were selected as the research subjects, and they were divided into observation group (30 cases) and control group (30 cases) by random number table method.The control group received routine swallowing function training, and the observation group received rehabilitation training combined with intermittent oral to esophageal tube feeding training.The grading of frog field drinking test and the treatment effect of swallowing function were compared between the two groups after training.Results The classification of frog field drinking water test in the observation group was better than that in the control group,and the difference was statistically significant (P＜0.05).The total effective rate of swallowing function in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Rehabilitation training combined with intermittent oral to esophageal tube feeding training for stroke patients with dysphagia can improve the swallowing function of the patients and effectively promote the rehabilitation of the patient′s condition, which has a high application value. 2021 Vol. 28 (10): 75-77 [Abstract] ( 34 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 78 Clinical effect of Loratadine Citrate combined with Fluticasone Propionate in the treatment of neurodermatitis HE Wen-qiang Objective To explore the effective effect of Loratadine Citrate combined with Fluticasone Propionate in the treatment of neurodermatitis.Methods A total of 96 patients with neurodermatitis admitted to Iron Coal General Hospital of Liaoning Health Industry Group from December 2018 to December 2019 were selected as research object.They were divided into an observation group (n=48) and a control group (n=48) by odd-even grouping.The control group was treated with Fluticasone Propionate, and the observation group was treated with Loratadine citrate combined with Fluticasone Propionate.The clinical effect of the two groups and the target skin lesion area and skin lesion score before and after treatment, skin itching score and eczema condition index score were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05); After treatment, the target skin lesion area, skin lesion degree score, skin itching score and eczema condition index score of the two groups of patients were lower than those before treatment, and the differences were statistically significant (P＜0.05); the target skin lesion area, skin lesion degree score, skin itching score and eczema condition index score of the two groups of patients were all lower than those of the control group, the differences were statistically significant (P＜0.05).Conclusion Patients with neurodermatitis treated with Loratadine Citrate combined with Fluticasone Propionate can significantly reduce the itchiness and eczema of the patient, significantly improve the degree of skin lesions of the patient.It′s application value is high. 2021 Vol. 28 (10): 78-80转84 [Abstract] ( 57 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 81 Clinical analysis of thrombocytopenia in patients with acute myocardial infarction after intra-aortic balloon counterpulsation WANG Li-zhi ；GUO Yan-qing； WANG Hai-shu； WANG Jian-zhong； WANG Jing-ping； LI Li Objective To investigate the causes of thrombocytopenia in patients with acute myocardial infarction using intra-aortic balloon pump (IABP).Methods Clinical data of 120 patients with acute myocardial infarction using IABP who were admitted to Shanxi Provincial Cardiovascular Disease Hospital from December 2017 to February 2020 were retrospectively analyzed.The time of application of IABP and the changes of platelets after application were recorded.The relationship between thrombocytopenia and age, sex and balloon size, and the influence of thrombocytopenia on the duration of IABP use and mortality in hospital were analyzed.Results The duration of IABP application ranged from 1 to 52 d, with an average of (10.04±8.04) d.After IABP treatment, 58 patients (48.3%) developed thrombocytopenia, and the mean time of minimum platelet count was (3.45±1.30) d.Among them, 51 cases were mild, 5 cases were moderate,and 2 cases were severe.The proportion of 40 CC balloon in patients with thrombocytopenia (87.9%) was higher than that in patients without thrombocytopenia (72.6%), and the difference was statistically significant (P＜0.05).There were no significant differences in age, gender and duration of IABP between patients with thrombocytopenia and patients without thrombocytopenia (P＞0.05).There was no significant difference in mortality between patients with thrombocytopenia (31.0%) and patients without thrombocytopenia (24.2%) (P＞0.05).Conclusion Thrombocytopenia in patients with acute myocardial infarction treated with IABP is mainly related to balloon size, and thrombocytopenia does not increase the mortality of patients. 2021 Vol. 28 (10): 81-84 [Abstract] ( 44 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 85 Effect of Carvedilol combined with Trimetazidine on vascular endothelial function, blood nitric oxide and endothelin-1 in patients with heart failure ZHAO Xin Objective To investigate the effect of Carvedilol combined with Trimetazidine on vascular endothelial function, blood nitric oxide and endothelin-1 in patients with heart failure.Methods A total of 52 patients with heart failure who were treated in the Affiliated Central Hospital of Shenyang Medical University from April 2019 to April 2020 were selected as the research objects.By drawing lots,they were divided into control group and study group, with 26 cases in each group.Patients in both groups were given conventional treatment with vasodilators, diuretics and tensin anticoagulants.Patients in the control group were treated with Carvedilol on the basis of conventional treatment, and patients in the study group were treated with Carvedilol combined with Trimetazidine on the basis of conventional treatment.The levels of endothelin-1, blood nitric oxide, left ventricular end-diastolic diameter (LVDD), left atrial diameter(LAD), left ventricular ejection fraction (LVEF) and ventricular septal thickness (IVST) before and after treatment and vascular endothelial function after treatment were compared between the two groups.Results Before treatment, there were no statistically significant differences in the levels of endothelin-1 and nitric oxide between the two groups (P＞0.05).After treatment, the levels of endothelin-1 in the two groups were lower than those before treatment, and the levels of blood nitric oxide were higher than those before treatment, the differences were statistically significant (P＜0.05).After treatment, the level of endothelin-1 in the study group was lower than that in the control group, and the level of blood nitric oxide was higher than that in the control group, the differences were statistically significant (P＜0.05).After treatment, the vasodilator function in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Before treatment,there were no statistically significant differences in LVDD, LAD, LVEF and IVST between the two groups (P＞0.05).After treatment, LVDD, LAD and IVST of the two groups were lower than those before treatment, LVEF was higher than before treatment, and the differences were statistically significant (P＜0.05).After treatment, LVDD, LAD and IVST in the study group were lower than those in the control group, LVEF was higher than that in the control group, and the differences were statistically significant (P＜0.05).Conclusion Carvedilol combined with Trimetazidine has an ideal effect in the treatment of heart failure.It can increase blood nitric oxide levels, reduce endothelin-1 levels, improve heart function, and improve vasodilation.It is recommended to be used in clinical practice. 2021 Vol. 28 (10): 85-88 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 89 Effect of Clopidogrel combined with Aspirin in the treatment of acute myocardial infarction FANG Yang； JIN Lei Objective To investigate the effect of Clopidogrel combined with Aspirin in the treatment of acute myocardial infarction.Methods A total of 86 patients with acute myocardial infarction admitted to Benxi Central Hospital from December 1, 2018 to January 15, 2020 were selected as the research objects.According to the odd and even number grouping method, they were divided into the observation group and the control group, with 43 cases in each group.The observation group was treated with Clopidogrel combined with Aspirin, while the control group was treated with Aspirin.The therapeutic effect, cardiac function changes before and after treatment (left ventricular ejection fraction [LVEF], left ventricular end-diastolic diameter [LVEDD], 6 min walking distance [6MWD]), cardiovascular events and the total incidence of adverse reactions in the two groups were compared.Results The total effective rate in observation group(97.67%) was higher than that in control group (79.07%), and the difference was statistically significant (P＜0.05).After treatment, LVEF and 6MWD in the observation group were higher than those in the control group, LVEDD was lower than that in the control group, and the differences were statistically significant (P＜0.05).The total incidence of cardiovascular events in the observation group (4.65%) was lower than that in the control group (18.60%), the total incidence of adverse reactions in the observation group (4.65%) was lower than that in the control group (18.60%), and the differences were statistically significant (P＜0.05).Conclusion The combination of Clopidogrel and Aspirin in the treatment of acute myocardial infarction can significantly improve heart function and have a low incidence of cardiovascular events.It is worthy of clinical promotion and application. 2021 Vol. 28 (10): 89-91转95 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 5 ) 92 Effect of Metoprolol in the treatment of acute heart failure complicated with atrial fibrillation and its influence on cardiac function LIU Lin-lin Objective To investigate the effect of Metoprolol in the treatment of acute heart failure complicated with atrial fibrillation and its influence on cardiac function.Methods Clinical data of 120 patients with acute heart failure complicated with atrial fibrillation in Panjin Central Hospital from December 2017 to December 2018 were retrospectively analyzed and divided into the control group and the treatment group according to different treatment methods,with 60 cases in each group.The control group was treated with deacetylcamoside Injection and Nitroglycerin Injection,and treatment group was treated with Metoprolol on the basis of control group.The total effective rate, the incidence of adverse reactions, the improvement of cardiac function indexes before and after treatment, the quality of life score, the disappearance time of heart failure symptoms, the return time of electrocardiogram results and the total time of hospitalization were compared between the two groups.Results The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The incidence of adverse reactions in the treatment group was lower than that in the control group, and the difference was statistically significant (P＜0.05).After treatment, the left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD)of the treatment group were lower than those of the control group,the quality of life scale(SF-36)score and left ventricular ejection fraction (LVEF) of the treatment group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The time of symptom disappearance, electrocardiogram results return to normal and total hospitalization time in the treatment group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion Treatment with Metoprolol in patients with acute heart failure combined with atrial fibrillation can greatly improve cardiac function, reduce the incidence of adverse drug reactions, effectively shorten the time for disease control and the length of hospital stay of patients, and improve clinical efficacy and quality of life. 2021 Vol. 28 (10): 92-95 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 96 Efficacy of Nicorandil combined with Isosorbide Mononitrate on myocardial microcirculation perfusion in patients with acute myocardial infarction SONG Qing-hua; HE Qian; HU Wen-biao;LU Yuan-xi; PAN Qiao-lin;SU Wen-jian Objective To investigate the efficacy and safety of Nicorandil combined with Isosorbide Mononitrate in patients with acute myocardial infarction undergoing interventional therapy.Methods A total of 86 patients with acute myocardial infarction admitted to the Second Nanning People′s Hospital from January 2018 to January 2020 were selected as the research subjects.According to random number table method, they were divided into the control group and the observation group, with 43 cases in each group.The control group received Isosorbide Mononitrate after interventional therapy, and the observation group was additively treated with Nicordil at admission and after interventional therapy.Cardiac function, myocardial microcirculation perfusion, serological indexes and the incidence of adverse reactions were compared between the two groups.Results There was no statistically significant difference in the cardiac function between the two groups before operation(P＞0.05).At 30 days after surgery, the left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) of the two groups were lower than those before surgery, the left ventricular ejection fraction (LVEF)was higher than that before surgery, and the differences were statistically significant (P＜0.05).At 30 days after surgery,the LVEDD and LVESD in the observation group were (43.16±3.82) and (34.67±3.81) mm, lower than (47.65±3.98) and(38.28±3.94) mm in the control group, the LVEF was (54.41±4.62)%, higher than (50.39±4.53)% in the control group,and the differences were statistically significant (P＜0.05).The sum of capillary cross-sectional area, blood flow velocity and myocardial blood flow in observation group were (15.42±1.75) cm2, (0.79±0.16) cm/s and (12.03±1.53) L/min, which were higher than (13.95±1.68) cm2, (0.72±0.14) cm/s and (10.21±1.42) L/min in control group, and the differences were statistically significant (P＜0.05).There were no statistically significant differences in preoperative serum indexes between the two groups before operation (P＞0.05).The 24 h postoperative levels of troponin I (cTnI) and N-terminal probrain natriuretic peptide (NT-proBNP) were higher than those before operation in the two groups, and the differences were statistically significant (P＜0.05).The 24 h postoperative levels of cTnI and NT-proBNP in the observation group were (60.14±7.25) μg/L and (769.35±70.16) ng/L, which were lower than (69.43±7.36) μg/L and (903.41±81.53) ng/L in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant differences in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Nicorandil combined with Isosorbide Mononitrate improves myocardial microcirculation perfusion in patients undergoing interventional therapy for acute myocardial infarction, which accelerates the recovery of cardiac function and reduces the levels of cTnI and NT-proBNP.It is safe and reliable. 2021 Vol. 28 (10): 96-99 [Abstract] ( 47 ) HTML (39 KB)  PDF  (0 KB)  ( 6 ) 100 Application study of noninvasive dynamic monitoring of brain edema in the treatment of cerebral hemorrhage diseases RAO Wei ;CAO Wen-feng Objective To explore the application of noninvasive dynamic monitoring of brain edema in the treatment of cerebral hemorrhage disease.Methods A total of 50 patients with intracerebral hemorrhage disease in Jiangxi Provincial People′s Hospital from January 2019 to January 2020 were selected as the research objects, and they were divided into the observation group (25 cases) and the control group (25 cases) according to the principle of random drawing and grouping methods.The observation group was treated with minimally invasive hematoma removal, and the control group was treated with conservative medical treatment.The comprehensive disturbance coefficient and National Institute of Health stroke scale (NIHSS) score of the two groups were compared.Results With the progress of the disease course,the disturbance coefficient of the affected side in the control group increased and exceeded that of the healthy side, and reached the peak at the third day.The indexes of the affected side in the observation group were lower than those in the same group at the third day, and the indexes of the affected side were higher than those in the same group at the fifth day, the differences were statistically significant (P＜0.05).The comprehensive disturbance coefficient of the affected side in the observation group on the third and fifth days were significantly different from that in the control group(P＜0.05).After treatment, the NIHSS scores of the observation group on the 3rd, 5th and 8th days were lower than those of the control group (P＜0.05).Conclusion Noninvasive dynamic monitoring of brain edema is of great significance in the treatment of cerebral hemorrhage diseases.The comprehensive disturbance coefficient changes dynamically with the progress of the course of disease, which can reflect the dynamic changes of edema in the surrounding tissues of patients with intracerebral lesionsm, and it can timely feedback the patient′s situation, improve the treatment effect and improve the prognosis of patients, which is worthy of research and promotion. 2021 Vol. 28 (10): 100-102 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 103 Effect observation of hard channel puncture and drainage and intraoperative irrigation in the treatment of chronic subdural hematoma in middleaged and elderly ZHANG Chong-tai ；WU Jun ；XU Wen-yun Objective To investigate the clinical effect of hard channel puncture drainage and intraoperative irrigation in the treatment of chronic subdural hematoma (CSDH) in middle-aged and elderly.Methods A total of 60 middleaged and elderly patients with CSDH admitted to Shangrao Municipal Hospital from January 1, 2018 to January 10,2020 were selected as the research objects.According to different treatment methods, they were divided into the control group and the observation group, 30 cases in each group.The control group used traditional drilling and drainage, and the observation group used hard channel puncture and drainage and intraoperative irrigation.The total clinical treatment efficiency, clinical related indicators, the incidence of complications and the recurrence rate were compared between the two groups.Results There was no significant difference in the total clinical treatment effective rate between the two groups (P＞0.05).The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).There was no significant difference in the recurrence rate between the two groups (P＞0.05).The operation time, drainage time, and hospitalization time of the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05).Conclusion The clinical effective rate of hard channel puncture and drainage and intraoperative irrigation in middle-aged and elderly patients with CSDH is higher, which helps to shorten the operation time, drainage time, hospitalization time, and the incidence of complications and recurrence rate are lower. 2021 Vol. 28 (10): 103-105转112 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 106 Clinical research of Agomelatin in the treatment of depression DU Li-hui ；HUANG Jin-rong； ZOU Cheng-lin； XU Chen-wen Objective To investigate the effect and safety of Agomelatine in the treatment of depression.Methods A total of 197 patients with depression in Ganzhou People′s Hospital from June 2017 to December 2018 were selected as the research objects, according to the double-blind random method, they were divided into the observation group (101 cases, 3 cases of shedding and the rest 98 cases) and the control group (96 cases, 2 cases of shedding and the rest 94 cases).The control group was treated with Paroxetine, and the observation group was treated with Agomelatine.The clinical effective rate, Hamilton depression scale (HAMD) score and adverse reactions were compared between the two groups.Results The clinical effective rate of the observation group was 91.84%, compared with 93.62% of the control group, the difference was not statistically significant (P＞0.05).The HAMD scores of the two groups at the end of the 2nd and 4th weeks were lower than those before treatment, and the HAMD scores of the observation group at the end of the 2nd and 4th weeks were lower than those of the control group, the differences were statistically significant (P＜0.05).There were no significant differences in the incidence of sleep disorders, upright collapse, physical fatigue, headache, palpitation, tremor, dysuria, sweating, dry mouth, constipation, sleepiness and other adverse reactions between the two groups(P＞0.05).The incidence of sexual dysfunction in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Both Agomelatine and Paroxetine can safely and effectively improve the symptoms of patients with depression, and the clinical efficacy is roughly the same, but Agomelatine has little effect on sexual function. 2021 Vol. 28 (10): 106-108转116 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 5 ) 109 Application effect of mindfulness based therapy in patients with chronic tension-type headache LI Pu-hua ；HUANG Dan-dan； HUANG Han-ning； HUANG Jin-yan Objective To explore the application effect of mindfulness based therapy in patients with chronic tensiontype headache.Methods A total of 92 patients with chronic tension-type headache admitted to Gaozhou People′s Hospital from January 2018 to June 2020 were selected as the research objects.They were divided into the observation group(n=46)and the control group(n=46)by the random number table method.Both groups were given oral administration of Eperisone Hydrochloride Tablets, 50 mg each time, 3 times a day.In the observation group, mindfulness based therapy was added.Both groups were treated for 8 weeks.The clinical efficacy of the two groups was evaluated.The improvement of clinical symptoms before and after treatment was recorded.The sleep quality of the two groups was assessed using the Pittsburgh sleep quality index (PSQI), and the quality of life of the two groups was assessed using a concise quality of life scale.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).After treatment, the duration of headache of the observation group was shorter than that of the control group, and the headache degree score and total PSQI score were lower than those of the control group, with statistical significances (P＜0.05).After treatment, the quality of life of the two groups was improved, and the scores of the quality of life items in the observation group such as physical pain,general health, mental health, emotional function, physiological function, social function, and vitality were higher than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion On the basis of conventional treatment, implementing mindfulness based therapy can help improve the clinical efficacy of chronic tension-type headache, the clinical symptoms and sleep quality, and thus ameliorate the quality of life. 2021 Vol. 28 (10): 109-112 [Abstract] ( 39 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 113 Effect and safety of Ziprasidone combined with Olanzapine in the treatment of treatment-resistant schizophrenia CAO Bao-rui；CHEN Jia-min； MA Qing Objective To investigate the effect and safety of Ziprasidone combined with Olanzapine in the treatment of treatment-resistant (TRS).Methods A total of 72 TRS patients diagnosed at Zaozhuang Mental Health Center and Heze Third People′s Hospital from March 2018 to December 2019 were selected as the research objects.According to the random number table method, the patients were divided into the control group (Olanzapine treatment) and the observation group (Ziprasidone treatment based on the control group), with 36 cases in each group.Before treatment and after 3 months of treatment, the positive and negative symptom scale (PANSS) was performed to assess the severity of symptoms in patients, and the total effective rate was calculated based on the PANSS score.The Wechsler memory scale(WMS) and trail making test (TMT) were used to evaluate the patients′ cognitive function.The total incidence of adverse reactions was compared between the two groups.Results The total effective rate of treatment in the observation group (91.67%) was higher than that in the control group (72.22%), with statistically significant difference (P＜0.05).After treatment, the WMS scores of the two groups were higher than those before treatment, and the WMS score in the observation group was higher than that in the control group, with statistically significant differences (P＜0.05).The TMT scores of the two groups were lower than those before treatment, and the TMT score in the observation group was lower than that in the control group, with statistically significant differences (P＜0.05).The total incidence of adverse reactions such as salivation, dizziness, headache, drowsiness, constipation and epilepsy in the control group was 27.78%, and 19.44% in the observation group, there was no significant difference between the two groups (P＞0.05).Conclusion The combination of Ziprasidone and Olanzapine has a good effect in the treatment of TRS, which significantly improves the cognitive function of patients without increasing the total incidence of adverse reactions. 2021 Vol. 28 (10): 113-116 [Abstract] ( 45 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 117 Effect of Butylphthalide Soft Capsules combined with Edaravone on neurological deficit score and inflammatory factors in patients with acute cerebral infarction WU Xi Objective To investigate the effect of Butylphthalide Soft Capsules combined with Edaravone on neurological deficit score and inflammatory factors in patients with acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction admitted to Iron Coal General Hospital of Liaoning Health Industry Group from May 2018 to October 2019 were selected as the research objects.They were divided into the observation group (50 cases) and the control group (50 cases) according to the sequence of admission.The patients in the observation group were treated with Butylphthalide Soft Capsules combined with Edaravone, and patients in the control group were treated with Butylphthalide Soft Capsules.The neurological deficit score, quality of life, the level of high-sensitivity C-reactive protein and hemorheology indexes were compared between the two groups.Results The neurological deficit score of the observation group after treatment was lower than that of the control group, and the difference was statistically significant (P＜0.05).The quality of life scores of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The high-sensitivity C-reactive protein levels in the observation group were lower than those of the control group at 24 h and 7, 14 days after treatment, and the differences were statistically significant (P＜0.05).The hemorheology indexes of the observation group after treatment were lower than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion The application of Butylphthalide Soft Capsules combined with Edaravone in the treatment of acute cerebral infarction can improve the neurological deficit score and inflammatory factors, and improve the quality of life of patients, which is worthy of study and promotion. 2021 Vol. 28 (10): 117-119 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 4 ) 120 Clinical study of minimally invasive percutaneous nephrolithotomy combined with flexible ureteroscopy in the treatment of complex kidney stones LIU Jiang ；GUO Li-hui； MIAO Xiao-hong； WANG Zhi-wei； ZHONG Shao-yun Objective To explore the clinical value of minimally invasive percutaneous nephrolithotomy (mPCNL) combined with flexible ureteroscopy in the treatment of complex kidney stones, and to provide guidance for optimizing the treatment plan.Methods A total of 60 patients with complicated kidney stones admitted in Xingang Central Hospital from January 2018 to December 2019 were selected as the research objects and divided into the control group and the study group according to the random number table method, with 30 cases in each group.The control group chose standard channel percutaneous nephroscope holmium laser lithotripsy, and the study group chose mPCNL combined with flexible ureteroscope holmium laser lithotripsy.The perioperative changes in related indicators, the levels of serum cortisol (Cor) and C-reactive protein (CRP) before and the next day after the operation, the urinary tract infections and stone clearance counted 3 days after the operation of two groups were compared.Results The operation time of the study group was longer than that of the control group, and the blood loss during operation was fewer than that of the control group, the postoperative hospital stay was shoter than that of the control group, the differences were statistically significant (P＜0.05).The comparison of serum Cor and CRP before operation between the two groups was not statistically significant (P＞0.05).The serum levels of Cor and CRP on the next day after surgery were lower than those before surgery, and the above indicators of the study group were lower than those of the control group, the differences were statistically significant(P＜0.05).The incidence of urinary tract infection in the study group was lower than that in the control group, and the stone clearance rate was higher than that in the control group, the differences were statistically significant (P＜0.05).Conclusion The mPCNL combined with flexible ureteroscopy for patients with complex kidney stones has a better effect, which can control and reduce intraoperative blood loss, shorten postoperative hospital stay, reduce serum Cor and CRP levels and the risk of urinary tract infections, and improve stone removal. 2021 Vol. 28 (10): 120-122转126 [Abstract] ( 48 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 123 Clinical study of circulating blood tumor cell detection in the evaluation after radical cystectomy KANG Xi； LI qin； LIU fang Objective To investigate the application value of circulating tumor cells (CTC) in the evaluation of radical cystectomy.Methods From June 2018 to October 2019, ninety patients with bladder cancer undergoing radical cystectomy in Pingxiang People′s Hospital were selected as the study group, and ten non tumor patients in Pingxiang People′s Hospital at the same time were selected as the control group.Before operation, 7.5 mL of peripheral venous blood was collected and separated by negative enrichment method.Peripheral CTC was detected by immunofluorescent in situ hybridization (imFISH) detection technology.The relationship between the positive rate of CTC and clinicopathological characteristics of bladder cancer patients, and the relationship between CTC expression level and prognosis of bladder cancer patients were analyzed.Results The positive detection rate of CTC in the study group was higher than that in the control group, the difference was statistically significant (P＜0.05).The CTC positive rate of multiple tumors was higher than that of single tumor, the CTC positive rate of tumor diameter ≥3 cm was higher than that of ＜3 cm, the CTC positive rate of ≥T2 stage was higher than that of ＜T2 stage, the CTC positive rate of high-grade tumors was higher than that of low-grade tumors, the CTC positive rate of recurrent patients was higher than that of non-recurrence patients, and the differences were statistically significant (P＜0.05).The survival curve showed that the survival rate of CTC positive expression was higher than that without CTC positive table, the difference was statistically significant (P＜0.05).Conclusion CTC is closely related to tumor number, tumor diameter, pathological grade, T stage and recurrence of bladder cancer.The expression of CTC is closely related to the prognosis of patients with bladder cancer, which can be used as an independent index to predict the prognosis of bladder cancer. 2021 Vol. 28 (10): 123-126 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 127 Clinical effect of three-leaf plasma enucleation of prostate in treatment of benign prostatic hyperplasia YI Ai-guo； XU Wen-yuan； HU Xiao Objective To investigate the clinical effect of three-leaf plasma prostatectomy for benign prostatic hyperplasia.Methods A total of 77 cases of benign prostatic hyperplasia admitted in the Second People′s Hospital of Yichun City from January 2014 to December 2019 were selected as the research objects.According to the odd and even number grouping method, they were divided into a reference group (42 cases) and a treatment group (35 cases).Transurethral resection of the prostate was performed in the reference group, and three-leaf plasma prostatectomy was performed in the treatment group.The intraoperative blood loss, washing time, extubation time, the volume of the prostate specimen obtained, the length of hospital stay, the international prostate symptom score (IPSS) score and the occurrence of complications were compared between the two groups.Results The amount of blood loss, washing time,extubation time, and hospital stay in the treatment group were shorter than those in the reference group, and the differences were statistically significant (P＜0.05).The volume of prostate specimens obtained by patients in the treatment group was larger than that in the reference group, and the difference was statistically significant (P＜0.05).The IPSS score of patients in the treatment group was lower than that of the reference group one month after surgery, the difference was statistically significant (P＜0.05).The postoperative complication rate of patients was lower than that of the reference group, the difference was statistically significant (P＜0.05).Conclusion Trefoil plasma prostatic enucleation in the treatment of patients with benign prostatic hyperplasia can reduce the intraoperative blood loss, shorten the hospital stay, improve prostate symptoms, and reduce complications. 2021 Vol. 28 (10): 127-129 [Abstract] ( 38 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 130 Comparison of the efficacy of flexible ureteroscopy or percutaneous nephroscopy combined with EMS holmium laser on the treatment of incomplete staghorn kidney stones ZHU Ke1 LI Jian;ZHOU Jian; BAI Tian;CAO Bo;WEN Gang;TANG Jing-jing;HUANG Xiang Objective To compare the clinical efficacy of flexible ureteroscopic lithotripsy (FURS) and percutaneous nephrolithotripsy (PCNL) combined with EMS holmium laser in the treatment of incomplete staghorn renal calculi.Methods A total of 103 patients with incomplete staghorn nephrolithiasis admitted to Sichuan Provincial People′s Hospital Jinniu Hospital from March 2016 to December 2019 were selected as the research objects and divided into the FURS group(48 cases)and the PCNL group(55 cases)according to different treatment methods.The operative time,intraoperative blood loss, postoperative haemoglobin decline, hospital expenses, length of stay, success rate of stone extraction in phase Ⅰ, total stone clearance rate and total incidence of complications of two surgical methods combined with EMS holmium laser in the treatment of incomplete staghorn renal calculi were compared.Results The operation time of FURS group was longer than that of PCNL group, intraoperative blood loss of FURS group was less than that of PCNL group, the postoperative haemoglobin decline of FURS group was lower than that of PCNL group, the length of stay of FURS group was shorter than that of PCNL group, success rate of stone extraction in phase Ⅰof FURS group was lower than that of PCNL group, the differences were statistically significant (P＜0.05).There were no significant differences between the two groups in the total stone clearance rate and the total incidence of complications (P＞0.05).And seven cases of FURS group employed postoperative EWSL treatment, four cases of PCNL group employed EWSL treatment.Conclusion FURS combined with EMS holmium laser lithotripsy and PCNL combined with EMS holmium laser lithotripsy are safe and effective methods for the treatment of incomplete staghorn calculi.Compared with flexible ureteroscopy, percutaneous nephroscope lithotripsy has a high rate of stone clearance and shorter operation time, it is more suitable for ＞20 mm diameter kidney stones, especially the complete large staghorn stones.It can decrease intraoperative blood loss, reduce the postoperative bleeding rate, and shorter the length of stay of FURS combined with EMS holmium laser lithotripsy. 2021 Vol. 28 (10): 130-133 [Abstract] ( 33 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 134 Application effect of out-of-hospital blood glucose management system in patients with type 2 diabetes mellitus LI Xian-cai； LI Chuan-yan； SONG Le-qin； LIN Shao-zhi； WANG Jia-yin ；GUO Pan Objective To observe the applicatio effect of the out-of-hospital blood glucose management system in patients with type 2 diabetes mellitus.Methods A total of 284 patients with type 2 diabetes mellitus whose blood glucose control was not up to standard who visited the Outpatient Department of Weifang Endocrine and Metabolic Hospital from May to December 2019 were selected as the research subjects.They were divided into an observation group (n=146) and a control group (n=138) according to the random number table method.The patients in the control group used routine outpatient blood glucose management, while the patients in the observation group received comprehensive blood glucose management by using the out-of-hospital blood glucose management system.Fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c) and blood glucose monitoring frequency before intervention, after 3 and 6 months of intervention were compared between the two groups.Results After 3 and 6 months of intervention, FPG and HbA1c in the two groups were lower than those before intervention, and the differences were statistically significant (P＜0.01).There were no significant differences in FPG and HbA1c between the two groups after 3 and 6 months of intervention(P＞0.05).There were no significant differences in FPG and HbA1c between the two groups before intervention (P＞0.05).After 3 and 6 months of intervention, the FPG and HbA1c of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05).After intervention for 3 or 6 months, the frequency of blood glucose monitoring in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.01).Conclusion Using the out-of-hospital blood glucose management system to manage the out-of-hospital blood glucose of patients with type 2 diabetes mellitus can significantly improve the frequency of blood glucose monitoring and reduce the blood glucose level. 2021 Vol. 28 (10): 134-136转140 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 137 Analysis of influencing factors of retinopathy in middle-aged and elderly patients with type 2 diabetes mellitus GUO Shuang; BAI Dong-zhi; WANG Yang Objective To investigate the influencing factors of diabetic retinopathy (DR) in middle-aged and elderly patients with type 2 diabetes mellitus.Methods A total of 460 middle-aged and elderly patients with type 2 diabetes mellitus who were admitted to Huludao Central Hospital from January 2018 to December 2019 were selected as the research subjects.They were subjected to history collection and physical examination, and fasting venous blood was collected to detect biochemical indicators.The fundus examination was performed by a professional ophthalmologist.According to the fundus conditions, they were divided into a normal fundus (NDR) group (295 cases) and a diabetic retinopathy (DR) group (165 cases).The prevalence of retinopathy in middle-aged and elderly patients with type 2 diabetes mellitus admitted to Huludao Central Hospital were summarized. Logistic regression model was used to analyze the correlation between DR and various influencing factors.Results The prevalence of DR was 35.9%, and the prevalence of DR was 18.1%, 31.6% and 53.8% in patients with disease course ＜5 years, 5-10 years and ＞10 years, respectively, the differences were statistically significant (P＜0.05).The course of disease, serum uric acid (SUA) and blood urea nitrogen (BUN) of the DR groups were higher than those of the NDR group, the differences were statistically significant (P＜0.05).There were no significant differences in age, gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), triglycerides(TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and serum creatinine (Scr)between the two groups. Logistic regression analysis showed that the course of disease (β=0.116, OR=1.123, 95%CI=1.087-1.160) and SUA (β=0.003, OR=1.003, 95%CI=1.000-1.005) were independent risk factors of DR (P＜0.05).Conclusion The prevalence of DR in middle-aged and elderly patients with type 2 diabetes mellitus significantly with the prolonged course of disease.Course of disease and SUA are independent risk factors for diabetic retinopathy. 2021 Vol. 28 (10): 137-140 [Abstract] ( 43 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 141 Effect of thoracic paravertebral nerve block on patients with single-port thoracoscopic radical resection of lung cancer JIANG Zhang-gui Objective To explore the effect of thoracic paravertebral nerve block (TPVB) on patients with single-port thoracoscopic radical surgery for lung cancer.Methods A total of 60 patients with single-port thoracoscopic radical resection of lung cancer treated in Shangrao People′s Hospital from May 2018 to May 2020 were selected as the research objects.According to the random number table method, they were divided into the experimental group and the control group, with 30 cases in each group.The control group was treated with simple general anesthesia, and the experimental group was treated with TPVB before anesthesia induction.The pain, the concentration of norepinephrine (NE), blood pressure, heart rate, and the dosage of sufentanil after surgery were compared between the two groups at different time points after surgery.Results The visual analogue scores (VAS) of the experimental group 2, 12, 24, 36 and 48 h after surgery were lower than those of the control group, the NE values of the experimental group at 5 min (T1) after thoracoscopic cannula insertion, immediately after the close of chest cavity (T2), 6 h after surgery (T3), and 24 h after surgery(T4) were lower than those of the control group, the systolic blood pressure, diastolic blood pressure, and heart rate were lower than the control group at the beginning, during and at the end of the surgery and the dosage of sufentanil was lower than that of the control group at the end of the surgery, the differences were statistically significant (P＜0.05).Conclusion Thoracic paravertebral nerve block can improve the postoperative analgesia effect of patients with singlehole thoracoscopic lung cancer radical surgery, reduce the use of anesthetic drugs, and can effectively stabilize the heart rate and blood pressure of patients. 2021 Vol. 28 (10): 141-143转147 [Abstract] ( 51 ) HTML (36 KB)  PDF  (0 KB)  ( 5 ) 144 Application effect of ultrasound-guided femoral nerve and lateral femoral cutaneous nerve block in elderly patients undergoing hip replacement FENG Xu Objective To analyze the application effect of ultrasound-guided femoral nerve and lateral femoral cutaneous nerve block in elderly patients undergoing hip replacement.Methods A total of 64 patients who underwent hip arthroplasty in Dandong Central Hospital of Liaoning Province from April 2017 to April 2018 were selected as the research objects.According to the random number table method, they were divided into the control group and the observation group, with 32 cases in each group.The control group was treated with simple intubation general anesthesia during the operation, while the observation group was treated with B-ultrasound-guided femoral nerve and lateral femoral cutaneous nerve block anesthesia during the operation.Before induction anesthesia (T0), skin incision (T1), 30 minutes after operation (T2), at the end of operation (T3) and 1 hour after operation (T4), the stress response indexes such as interleukin-6 (IL-6), blood glucose (Glu) and cortisol (Cor), as well as vital signs such as heart rate(HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) and stress response were compared between the two groups.Results The levels of HR, SBP and DBP at T1, T2, T3 and T4 in the control groups were lower than those at T0, and the differences were statistically significant (P＜0.05).The levels of HR, SBP and DBP at T1, T2, T3 and T4 in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).However,there was no significant difference in the levels of HR, SBP and DBP at T0 between the two groups (P＞0.05).The levels of IL-6, Glu and Cor at T1, T2, T3 and T4 in the control groups were higher than those at T0, and the differences were statistically significant (P＜0.05).The IL-6, Glu and Cor levels at T1, T2, T3 and T4 in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).However, there was no significant difference in IL-6, Glu and Cor levels between the two groups at T0 (P＞0.05).Conclusion B-ultrasound-guided femoral nerve and lateral femoral cutaneous nerve block in elderly patients with hip replacement surgery can obtain better anesthetic effect, maintain the patient′s stress response, and maintain a more stable level of vital signs.Therefore, it is especially suitable for elderly people with poor physical tolerance and poor autoimmune function, which is worthy of promotion and use. 2021 Vol. 28 (10): 144-147 [Abstract] ( 45 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 148 Effect of failure mode and effect analysis mode on the recovery complications of general anesthesia YUAN Fang-ping； LI Xiao-wei Objective To explore the influence of failure mode and effect analysis (FMEA) mode on the complications of general anesthesia during resuscitation.Methods A total of 200 patients with general anesthesia who were observed in the anesthesia resuscitation room of the Anesthesiology Department of the 73rd Army Hospital of the Chinese People′s Liberation Army from June to December in 2019 were selected as the research objects.According to the random number table method, they were divided into observation group and control group with 100 cases in each group.The patients in the control group were treated with routine nursing, while the patients in the observation group were treated with FMEA nursing mode.The incidence of abnormal blood pressure, pipeline shedding, irritability, delayed recovery,abnormal heart rate, complications and patient satisfaction were compared between the two groups after nursing.Results The total incidence of abnormal blood pressure, tube shedding, irritability, delayed recovery, abnormal heart rate and total complications rate in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05); the entrance assessment, resuscitation monitoring, exit assessment, and transfer and handover satisfaction ratings of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05).Conclusion The FMEA nursing model can effectively reduce the incidence of complications in patients undergoing general anesthesia resuscitation, reduce the occurrence of risk events, and improve the satisfaction rate of patients, which is worthy of clinical application. 2021 Vol. 28 (10): 148-150 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 151 Application effect of Dexmedetomidine in uterine laparoscopic combined surgery HAN Lei Objective To investigate the application effect of Dexmedetomidine on postoperative analgesia after uterine laparoscopic combined surgery.Methods A total of 60 patients undergoing uterine laparoscopic combined surgery in Beijing Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to January 2019 were selected as the research objects, and the patients were divided into two groups according to random number table method,with 30 patients in each group.Observation group was treated with Sufentanil 100 μg, Dexmedetomidine 200 μg, Ondansetron 8 mg prepared with 0.9% normal saline to 100 mL for postoperative analgesia, with continuous intravenous infusion of 2 mL every hour.The control group was treated with Sufentanil 100 μg, Ondansetron 8 mg prepared with 0.9% normal saline to 100 mL for postoperative analgesia, and the parameters of analgesia pump were the same as the observation group.The analgesic effect, sedative effect and occurrence of postoperative adverse reactions were compared between the two groups.The analgesic effect was evaluated by visual analogue scale (VAS), and the sedative effect was evaluated by Ramsay sedation scale.Results The VAS scores of observation group at 2, 6, 12, 24 and 48 h after surgery were lower than those of control group, the differences were statistically significant (P＜0.05).The Ramsay scores of observation group at 2, 6, 12, 24 and 48 h after surgery were higher than those of control group, the differences were statistically significant (P＜0.05).The incidence of nausea and vomiting, adjuvant analgesics, respiratory depression and total incidence of adverse reactions in observation group were lower than those in control group, with statistical significance (P＜0.05).Conclusion Dexmedetomidine is used for postoperative analgesia to significantly relieve postoperative pain in uterine laparoscopic combined surgery, reduce postoperative nausea and vomiting.Compared with Sufentanil alone for postoperative analgesia, Dexmedetomidine combined with Sufentanil has better postoperative analgesia effect and fewer adverse reactions, so it is worthy of application. 2021 Vol. 28 (10): 151-154 [Abstract] ( 46 ) HTML (40 KB)  PDF  (0 KB)  ( 5 ) 155 Clinical effect comparison of ultrasound-guided erector spinal muscle plane block and retrolaminar block in lumbar spine surgery ZOU Jia-rui； HUO Xiao-bei ；KANG Hong-zhe Objective To investigate the clinical application effect of ultrasound-guided erector spinal muscle plane block and retrolaminar block in lumbar spine surgery.Methods Eighty cases of lumbar spine surgery patients admitted to Dalian Central Hospital from August 2018 to May 2020 were selected as the research subjects.According to the random number table method, they were divided into two groups, each with 40 cases.In the observation group, bilateral erector spinal muscle plane block was used, and in the control group, retrolaminar block was adopted.The level of pain mediators during surgical skin incisions between the two groups was compared.The levels of antioxidants and inflammatory mediators during surgical skin incisions between the two groups were also compared.The numerical pain scale(NRS) score at different time points after surgery and incidence of adverse reactions were compared between the two groups.Results During surgical skin incision, the levels of 5-hydroxytryptamine (5-HT) and substance P (P) in the observation group were lower than those in the control group, with statistically significant differences (P＜0.05).The level of antioxidant substance superoxide dismutase (SOD) in the observation group during surgical skin incision was higher than that of the control group, the difference was statistically significant (P＜0.05).The inflammatory mediator interleukin-6 (IL-6) level in the observation group during surgical skin incision was lower than that in the control group,the difference was statistically significant (P＜0.05).The pain NRS scores of the observation group at 6, 12 and 24 h after surgery were lower than those of the control group, and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in observation group was lower than control group, and the difference was statistically significant (P＜0.05).Conclusion For patients undergoing lumbar spine surgery, the erector spinal muscle plane block can effectively reduce the body′s pain media release, alleviate pain, improve the body′s antioxidant capacity, and inhibit inflammation in high treatment safety. 2021 Vol. 28 (10): 155-158 [Abstract] ( 33 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 159 Study on the correlation between the changes of waistline and two kinds of immobilization methods in cervical cancer radiotherapy ZHONG Jia-jian; QIU Min-min; LIN Ze-huang; HUANG Tai-ming; MIN Meng-zhen; XIAO Zhen-hua; DENG Yong-jin Objective To explore the correlation between the changes of waistline and set-up errors of two kinds of immobilization methods in cervical cancer radiotherapy.Methods A total of 60 patients with cervical cancer who received radiotherapy in the First Affiliated Hospital, Sun Yat-sen University from June to December 2019 were retrospectively selected and divided into group A and group B according to the supine or prone position, with 30 cases in each group.Cone beam CT (CBCT) was performed once a week.The set-up errors of translation, rotation and waistline were recorded offline, and the correlation between the changes of waistline and set-up errors were calculated.Results The translation errors of X, Y and Z directions in group A were (-0.5±2.7), (-0.1±3.2), (-0.4±2.5) mm, and (-0.2±3.0),(-0.2±4.0), (2.0±4.1) mm in group B; the rotation errors of Rx, Ry and Rz in group A were (-0.6±2.2), (-0.2±0.8), (0.1±0.8)°, and (0.5±2.3), (-0.2±1.3), (0.5±0.9)° in group B.In Z, Rx and Rz directions, the difference between two groups was statistically significant (P＜0.05).The change of waistline △C in group A and B was (-2.3±2.7) and (-1.4±2.0) cm respectively, the difference between two groups was statistically significant (P＜0.05).There was a negative correlation between error of Z direction in group B and change of waistline △C (r=-0.618, P＜0.05).Conclusion In the supine position of cervical cancer radiotherapy, the repeatability is better, but the change of waistline will lead to serious adverse reactions.In the prone position, the protection of small bowel is better, but the change of waistline has a greater impact on the accuracy of Z direction.In clinic, the change of waistline should be paid attention and intervention of bladder filling and weight should be taken if necessary. 2021 Vol. 28 (10): 159-162 [Abstract] ( 37 ) HTML (40 KB)  PDF  (0 KB)  ( 8 ) 163 Clinical value of high frequency color Doppler ultrasound in the diagnosis of epididymal orchitis HUANG Can-bin;ZENG Wen-jing;XU Bi-qing Objective To explore the clinical application value of high frequency color Doppler ultrasound in the diagnosis of epididymal orchitis.Methods A total of 337 patients with scrotal lesions admitted to Guangzhou Panyu Central Hospital from August 2018 to July 2020 were selected as research objects.Conventional two-dimensional ultrasound and high-frequency color Doppler ultrasound were performed respectively for all patients.The detection rate and diagnostic value of the two methods for different diseases were compared, and the ultrasonic image manifestations of different diseases were analyzed.Results Clinical laboratory and clinical diagnosis showed that there were 12 cases of orchitis, 246 cases of epididymitis and 79 cases of orchitis with epididymitis.The sensitivity, specificity, accuracy, underdiagnosis rate and misdiagnosis rate of high frequency color Doppler ultrasound in the diagnosis of orchitis were 98.06%, 94.94%, 97.33%, 1.94% and 5.06%, respectively.The sensitivity, specificity, accuracy, underdiagnosis rate and misdiagnosis rate of conventional two-dimensional ultrasound for orchitis were 90.70%, 83.54%, 89.02%, 9.30%and 16.46%, respectively.The sensitivity, specificity and accuracy of high frequency color Doppler ultrasound were higher than those of conventional two-dimensional ultrasound, the underdiagnosis rate and misdiagnosis rate of high frequency color Doppler ultrasound were lower than those of conventional two-dimensional ultrasound, with statistical differences (P＜0.05) The ultrasonographic manifestations of orchitis, epididymitis and orchitis with epididymitis were different.Conclusion High frequency color Doppler ultrasound can accurately determine orchitis, epididymitis and orchitis combined with epididymitis, can diagnose the disease as soon as possible, and provide a scientific and standardized reference for subsequent treatment. 2021 Vol. 28 (10): 163-166 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 5 ) 167 Applicative value analysis of ultrasonic elastography parameters on diagnosis of breast tumor WEI Xiao-xi ;ZHU Wen-yan; WEN Hao-mao; DAI Zhao-jun Objective To explore the applied value of ultrasonic elastography parameters on diagnosis of breast tumor.Methods The clinical data about 60 breast tumor patients treated from January 2017 to October 2019 in the Second People′s Hospital of Foshan City was retrospectively analyzed.According to the nature of the tumor, thirty-one patients with benign tumor were included in the group A, and the remaining twenty-nine patients with malignant tumor were included in the group B.Both groups were examined by ultrasound.The clinical application value of elastic imaging and two-dimensional imaging were compared between the two groups.Results There were no significant differences in diameter and area of lesions between two-dimensional imaging and elastography imaging in group A (P＞0.05).The diameter and area of lesions based on elastography imaging in group B was larger than those of two-dimensional imaging,the differences were significantly different (P＜0.05).The diameter and area of lesions based on elastography imaging in group B was larger than those in group A, the differences were significantly different (P＜0.05).The diameter change rate and area ratio of group B were higher than that of group A, the differences were significantly different (P＜0.05).Compared the ratio of patients from grade 1 to grade 5 of tumor hardness for group A (19.35%, 29.03%, 41.94%,9.68% and 0.00%) and group B (0.00%, 6.90%, 13.79%, 44.83% and 34.48%), the differences were significantly different (P＜0.05).The incidence of typical ultrasonic features in group B was higher than that in group A, the differences were significantly different (P＜0.05).Conclusion The ultrasonic elastography parameters are used to quantitatively determine the tumor hardness, typical features and area, which plays a significant role in the differential diagnosis of benign and malignant tumor.It is worthy of clinical promotion and application. 2021 Vol. 28 (10): 167-169 [Abstract] ( 35 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 170 Comparison of ultrasonographic features of Hashimoto′s thyroiditis with benign and malignant nodules ZHANG Jia-rong Objective To investigate the ultrasonographic features of Hashimoto thyroiditis (HT) with benign and malignant nodules.Methods A total of 87 patients with HT complicated nodules admitted to Dongnan Hospital from February 2016 to December 2019 were retrospectively selected as the research subjects.According to the pathological examination results of thyroid nodule puncture, they were divided into malignant nodule group (30 cases) and benign nodule group (57 cases).The two-dimensional ultrasound imaging features (echo, morphology, aspect ratio, sound halo, microcalcification, structure, boundary) and color Doppler flow imaging features (flow grade, resistance index value) were compared between the two groups.Results The proportion of hypoecho, irregular shape, aspect ratio≥1, acoustic halo and microcalcification in the malignant nodules group were higher than those in the benign nodules group, and the differences were statistically significant (P＜0.05).There were no significant differences in structure and boundary between the two groups (P＞0.05).The proportion of the blood flow grade (grade Ⅱand Ⅲ) and resistance index value ≥0.7 in the malignant nodules group were higher than those in the benign nodules group, and the differences were statistically significant (P＜0.05).Conclusion There were significant differences between benign and malignant HT nodules in low echo, irregular shape, aspect ratio, sound halo, microcalcification, blood flow grade and resistance index value, which were helpful for differential diagnosis. 2021 Vol. 28 (10): 170-172转176 [Abstract] ( 46 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 173 The value of color Doppler ultrasound in the diagnosis of thyroid nodules PENG Gui-ping Objective To explore the value of color Doppler ultrasound in the diagnosis of thyroid nodular lesions.Methods Forty eight patients with thyroid nodules admitted to Jiujiang First People′s Hospital from November 2019 to June 2020 were selected, and perform color Doppler ultrasound diagnosis on the patients, the gold standard was pathological diagnosis, and analyzed the diagnostic accuracy, benign and malignant nodules of color Doppler ultrasound Ultrasonic characteristics and hemodynamic parameters of nodules.Results There was no significant difference between the diagnostic accuracy of color Doppler ultrasound and pathological results (P＞0.05).The incidence rates of microcalcification, silent halo, irregular lesion, hypoechoic and unclear boundary in benign nodule group were lower than those in malignant nodule group, the differences were statistically significant (P＜0.05).The pulsatility index, resistance index and maximum velocity of benign nodules were lower than those of malignant nodules, and the minimum velocity of nodules was higher than that of malignant nodules, the differences were statistically significant (P＜0.05).Conclusion Color Doppler ultrasound has a high accuracy in the diagnosis of thyroid nodular lesions, which can be used to determine the benign and malignant nodules by ultrasound characteristics and hemodynamic parameters. 2021 Vol. 28 (10): 173-176 [Abstract] ( 40 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 177 Clinical value of color Doppler ultrasound in the diagnosis of bladder tumors GAO Hong-bo；WANG Min Objective To explore the clinical value of color Doppler ultrasound in the diagnosis of bladder tumors.Methods A retrospective analysis of 34 patients with bladder tumors diagnosed and treated in Lianzhou People′s Hospital from March 2019 to March 2020.All patients underwent surgical treatments in Lianzhou People′s Hospital and received color Doppler ultrasound examinations before surgery.Compared with surgical pathology, the clinical efficacy of and the diagnostic coincidence rate of different tumor number, positions and diameters of bladder tumors dignosed by color Doppler ultrasound.Results The accuracy of ultrasound in diagnosing bladder tumors was 88.2% (30/34); the specificity was 33.3% (1/3); and the sensitivity was 93.5% (29/31).In terms of number of tumors, the coincidence rate of color Doppler ultrasound diagnosis was 95.7%, and the coincidence rate of diagnosis was 87.5%.In terms of position of tumors, the coincidence rate of color photo diagnosis of sidewall was 93.3%; the coincidence rate of diagnosing the bottom was 100.0%; the coincidence rate of diagnosing the top was 66.7%, and the coincidence rate for the diagnosis of the neck was 100.0%.On the maximum diameter, the coincidence rate for color Doppler ultrasound diagnosis ＜10 mm was 87.5%; the coincidence rate of diagnosing tumor diameter being 10～20 mm was 94.7%; and the coincidence rate for diagnosis of tumor diameter ＞20 mm was 100.0%.Conclusion The use of color Doppler ultrasound to diagnose patients with bladder tumors has high clinical application value. 2021 Vol. 28 (10): 177-179 [Abstract] ( 38 ) HTML (29 KB)  PDF  (0 KB)  ( 8 ) 180 Comparative study of the efficacy of Decitabine and Azacitidine in the treatment of high-risk myelodysplastic syndrome LU Yu-hua； YANG Xin-ping； AO Zhi-wen； LI Ming Objective To compare the efficacy of Decitabine and Azacitidine in the treatment of high-risk myelodysplastic syndrome.Methods A total of 60 patients with high-risk myelodysplastic syndrome admitted to Yichun People′s Hospital from January 2018 to January 2020 were selected as the research subjects.According to the random number table method, they were divided into Decitabine group and Azacitidine group, with 30 cases in each group.In the Decitabine group, Decitabine was used, and in the Azacitidine group, Azacitidine was adopted.The clinical efficacy and the occurrence of side effect were compared between the two groups after six courses of treatment.Results The overall response rate (ORR) of the Decitabine group after six courses of treatment was higher than that of the Azacitidine group, and the difference was statistically significant (P＜0.05).In the Decitabine group, the incidence of bone marrow suppression, reduction of neutrophils, thrombocytes, and erythrocytes was superior to that in the Azacitidine group, and the difference was statistically significant (P＜0.05).Conclusion Decitabine is better than Azacitidine in the treatment of high-risk myelodysplastic syndrome, but it will increase the risk of toxic and side effect, which should be with caution on drug selection. 2021 Vol. 28 (10): 180-182转186 [Abstract] ( 126 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 183 Clinical effect of Lentinan in the treatment of patients with gastric cancer LI Hai-bo；SONG Yan Objective To explore the Clinical effect of Lentinan in the treatment of patients with gastric cancer.Methods A total of 150 patients with gastric cancer who were admitted to Yancheng No.1 People′s Hospital from January to December 2019 were selected as the research subjects.According to the random number table method, they were divided into control group and study group, with 75 cases in each group.The control group was treated with chemotherapy,and the study group was treated with Lentinan on the basis of the control group.The immune function and clinical efficacy before and after treatment as well as the adverse reactions and quality of life caused by chemotherapy were compared between the two groups.Results After treatment, the indexes of CD3+, CD4+, CD4+/CD8+, natural killer (NK)cells, immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) in the study group were higher than those of the control group, while the index of CD8+ was lower than that of the control group, the differences were statistically significant (P＜0.05).After treatment, there was no significant difference in the incidence of abnormal liver function between the two groups (P＞0.05).The incidence of leukopenia, gastrointestinal reaction and platelet decline in the study group were lower than those in the control group, and the improvement rate of quality of life was higher than that in the control group, the differences were statistically significant (P＜0.05).The effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion Lentinan has high therapeutic value in patients with gastric cancer, which is worthy of clinical application. 2021 Vol. 28 (10): 183-186 [Abstract] ( 57 ) HTML (39 KB)  PDF  (0 KB)  ( 9 ) 187 Effect and safety analysis of Tigecycline adjuvant treatment of multi-drug resistant bacteria infection in ICU patients JIANG Xiao-ming； LIU Xue-jing；SUN Yu Objective To investigate the effect and safety of ticacycline adjuvant treatment for multi-drug resistant bacterial infection in intensive care unit (ICU) patients.Methods A total of 60 patients with multidrug-resistant bacteria infection admitted to the ICU of Beijing Mentougou District Hospital from January 2019 to May 2020 were selected as the research subjects.According to stratified random method, they were divided into experimental group (30 cases) and control group (30 cases).The control group was treated with Cefoperazone and Sulbactam, and the experimental group was treated with Tigecycline on the basis of the control group.The recovery time of C-reactive protein (CRP), white blood cells, chest X-ray plain film, lung rales and body temperature were compared between the two groups.The total incidence of adverse reactions, bacterial reinfection rate, bacterial replacement rate and bacterial clearance rate were compared between the two groups.Results CRP, white blood cells, chest X-ray, lung rales and body temperature recovery time in experimental group were all shorter than those in control group, the differences were statistically significant(P＜0.05).The total incidence of adverse reactions, the rate of bacterial reinfection and the rate of bacterial replacement in experimental group were lower than those in control group, and the rate of bacterial clearance was higher than that in control group, the differences were statistically significant (P＜0.05).Conclusion The combination of Cefoperazone-Sulbactam and Tigecycline can accelerate the recovery of patients with multi-drug resistant bacteria infection and reduce the occurrence of bacterial infection and adverse reactions. 2021 Vol. 28 (10): 187-189 [Abstract] ( 38 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 190 Related problems and research progress of traditional Chinese medicine processing technology WANG Yu-xia；ZHOU Zai-fu Based on the study-tours of more than 20 bases of traditional Chinese medicine characteristic technology inheritance, from the two perspectives of traditional Chinese medicine processing technology inheritance and innovation,this paper discusses the traditional Chinese medicine processing literature, processing schools, processing in genuine producing area and apprentice education in the area of traditional Chinese medicine processing inheritance and other issues that need to be paid attention to.At the same time, it focuses on the quality evaluation of processed products,processing methods of producing areas and intelligent processing equipment, etc.and to analyze the aspects that need to be concerned in the field of innovation, and put forward opinions and suggestions. 2021 Vol. 28 (10): 190-193 [Abstract] ( 43 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 194 Experience of XIONG Wei-jian in diagnosis and treatment of urinary calculi ZHANG Peng-cheng；TANG Jing；CHENG Wan-hong；XIONG Wei-jian With the improvement of people′s living standard, the change of life style and work and rest pattern, the incidence rate of urinary calculi has also increased.How to prevent and treat urinary calculi has become a hot topic in urology.If urinary calculi are not treated actively, it may cause obstructive nephropathy or even renal failure.This paper discusses the clinical diagnosis and treatment of urinary calculi from the aspects of deficiency of kidney qi, dampness and heat in the lower jiao, qi stagnation and blood stasis, stone blocking collaterals and so on.It is based on through rows of stone method, combined with invigorating kidney qi, clearing heat and removing dampness, promoting qi and activating blood circulation, etc., with Sanjin Decoction as the basic prescription, the clinical effect is obvious and the injury and complications of the body are less. 2021 Vol. 28 (10): 194-196 [Abstract] ( 40 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 197 Mature cystic teratoma of the overy malignat transformation into adenocarcinoma with signet ring cell carcinoma:a case report JIA Xiang-qi； NAN Fang-fang Ovarian mature cystic teratoma is one of the common benign tumors in women of childbearing age, which is derived from germ cells and is composed of three kinds of tissues: entoderm,mesoblast and ectoderm.All of its components can become cancerous or coexist with other malignant epithelial tumors.The malignant transformation rate of mature cystic teratoma is very low (0.17%-3.00%), and it is more common in postmenopausal women.Because of its atypical early clinical symptoms, it is difficult to find before operation, so it is easy to miss diagnosis.Clinically, malignant transformation of teratoma is most common in squamous cell carcinoma, followed by adenocarcinoma, and others such as sarcoma and undifferentiated carcinoma are more rare.At present, there is no unified treatment for the malignant transformation of mature cystic teratoma.This paper reports a case of malignant transformation of ovarian teratoma into adenocarcinoma in Binzhou Medical College Affiliated Hospital and reviews the related literature. 2021 Vol. 28 (10): 197-199 [Abstract] ( 48 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 200 A case report of acquired immunodeficiency syndrome-associated cerebrovascular inflammation SHEN Jie； ZHANG Yan-mei； LYU Cui-lan； XU Gui-hua； GAO You-an Acquired immunodeficiency syndrome (AIDS), a kind of fatal infectious disease, is characterized by severe systemic immune deficiency, which may be involved gastrointestinal, cardiovascular and nervous systems, and so on.AIDS can also cause vasculitis-like changes, such as fibrinoid necrosis, inflammatory cells infiltration and thrombosis in the vascular vessels, and can lead to cerebral infarction or hemorrhage.Nonspecific clinical symptoms, which are similar to those of primary angiitis of the central nervous system (PACNS), lead to be misdiagnosed and mistreated.In this paper, a case with limb weakness of the AIDS-related cerebral vasculitis was confirmed, and the clinical symptoms and treatment process were introduced in detail.With the increasing number of human inmunodeficency virus (HIV) infections in China, the prevalence of AIDS-related cerebral infarction will increase year by year.Relevant professional doctors should pay attention to the possibility of such diseases to avoid misdiagnosis and mistreatment. 2021 Vol. 28 (10): 200-202转215 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 203 Application of GLTC doctor-patient communication model in the nursing of patients with trigeminal neuralgia ZHUGE Ting Objective To explore the application effect of GLTC doctor-patient communication model in the nursing of patients with trigeminal neuralgia.Methods A total of 80 patients with trigeminal neuralgia treated in the Fifth People′s Hospital of Shangrao City, Jiangxi Province from January 2017 to August 2019 were selected as the research objects.According to the random number table method, they were divided into the control group and the observation group,40 cases in each group.The control group used routine nursing, and the observation group used GLTC doctor-patient communication mode to implement intervention on the basis of routine nursing.The anxiety, depression, treatment compliance, and nursing satisfaction of the two groups were compared.Results At 4 weeks after nursing, the Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) scores of the two groups were lower than those before nursing, and HAMA, HAMD scores of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).At 4 weeks after nursing, the treatment total compliance of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).At 4 weeks after nursing, the nursing total satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion The GLTC doctor-patient communication model used in the nursing of patients with trigeminal neuralgia to implement intervention has a better effect, which can effectively reduce the anxiety and depression of patients, improve treatment compliance, and improve the nursing satisfaction of patients. 2021 Vol. 28 (10): 203-205 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 206 Application of the concept of rapid recovery in the nursing of patients undergoing lung cancer surgery ZHANG Xia； HE Lu-ying Objective To explore the application effect of the fast recovery (FTS) concept in the nursing of patients undergoing lung cancer surgery.Methods A total of 82 lung cancer patients who underwent surgical treated in Jiangxi Provincial Cancer Hospital from May 2017 to May 2018 were selected and divided into two groups according to random number table method, 41 cases in each group.The control group implements traditional intervention measures, and the intervention group implements the intervention measures of FTS concept, and both care until the patients are discharged.The stress response, hospitalization time, nursing satisfaction and postoperative complications were compared between the two groups.Results At 12 h after operation, the mean arterial pressure (MAP) level of the intervention group was lower than that of the control group, the difference was statistically significant (P＜0.05).The hospital stay in the intervention group was shorter than that in the control group, the difference was statistically significant (P＜0.05).The nursing total satisfaction of the intervention group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The postoperative total complication rate in the intervention group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The FTS concept can reduce the postoperative stress response of lung cancer patients, shorten the hospital stay, improve patient care satisfaction,and reduce the incidence of postoperative complications. 2021 Vol. 28 (10): 206-208 [Abstract] ( 45 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 209 Effect of nursing extension service on self-care behavior, complications and recurrence of lithotripsy under soft ureteroscope LIU Cui-lian Objective To investigate the effect of nursing extension service on self-care behavior, complications and recurrence of lithotripsy under soft ureteroscope.Methods From March 2018 to March 2019, 116 patients with soft ureteroscopic lithotripsy treated in Beijing Fangshan District Liangxiang Hospital were selected.They were divided into study group and reference group by random number table method, 58 cases in each group.All patients were treated with holmium laser lithotripsy under soft ureteroscope and nursing measures during perioperative period.The patients in the reference group were given routine discharge guidance at discharge, while the study group was given nursing extension service.After 6 months of intervention, the self-care behavior ability scores of the two groups were compared,and the complications of hematuria, urinary tract infection, low back pain and stone recurrence within one year were counted in the two groups.Results The scores of self-care behaviors in drinking water, scientific diet, regular diet and regular reexamination in the study group were higher than those in the reference group, the differences were statistically significant (P＜0.05).The total incidence of complications and stone recurrence rate in the study group were lower than those in the reference group, the differences were statistically significant (P＜0.05).Conclusion For patients with soft ureteroscopic lithotripsy, nursing extension service after discharge can improve self-care behavior, reduce postoperative complications and reduce the risk of recurrence of stones, which has the value of application. 2021 Vol. 28 (10): 209-211 [Abstract] ( 47 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 212 Effect of rehabilitation training and diet nursing intervention in patients with moderate dysphagia after stroke YU Hong； CUI Hong； WANG Xiao-xi Objective To investigate the effect of rehabilitation training and diet nursing intervention in patients with moderate dysphagia after stroke.Methods A total of 94 patients with moderate dysphagia after stroke admitted to Dalian Port Hospital from May 2018 to May 2020 were selected as the research objects.According to the random lottery method, they were divided into the reference group (47 cases) and the experimental group (47 cases).The patients in the reference group were treated with stroke rehabilitation and routine nursing, including enteral nutrition and simple education of dietary medication.The patients in the experimental group were treated with rehabilitation training and diet nursing intervention on the basis of symptomatic rehabilitation treatment and routine nursing of stroke, both groups were treated for 8 weeks.The improvement of dysphagia in the two groups were compared, and the nutritional indexes such as albumin and hemoglobin in the two groups were measured.The complications such as aspiration pneumonia,abdominal distension, diarrhea and gastroesophageal reflux in the two groups were analyzed.Results There was no significant difference in dysphagia score between the two groups before intervention (P＞0.05).The dysphagia scores in the two groups after intervention decreased, and the differences were statistically significant (P＜0.05).The score of dysphagia in the experimental group was lower than that in the reference group, and the difference was statistically significant(P ＜0.05).Albumin, hemoglobin and other nutritional indicators before intervention were compared between the two groups, there were no significant differences (P＞0.05).The nutritional indicators such as albumin and hemoglobin after intervention were higher than those before intervention in the two groups, and the differences were statistically significant(P＜0.05).The nutritional indicators such as albumin and hemoglobin in the experimental group were higher than those in the reference group, and the differences were statistically significant (P＜0.05).The total incidence rate of complications in the experimental group were lower than those in the reference group, and the differences were statistically significant (P＜0.05).Conclusion The application of rehabilitation training and diet nursing intervention has a good effect on patients with moderate dysphagia after stroke, which is helpful to improve dysphagia and improve the nutritional status of patients. 2021 Vol. 28 (10): 212-215 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 216 Exploration on the effect of psychological intervention on postpartum depression patients ZHANG Sai-rong; GUO Chao-jun; JIANG Qing Objective To study the effect of psychological intervention on postpartum depression.Methods A total of 70 patients with postpartum depression admitted to the Fourth People′s Hospital of Jingdezhen City, Jiangxi Province from January 2019 to January 2020 were selected as research objects, and were divided into the control group and the study group according to difference nursing plan, 35 cases in each group.Routine nursing mode was used in the control group, and psychological intervention was used in the study group on the basis of the control group.Clinical overall impression scale (CGI-SI), serum estradiol content, progesterone content, nursing satisfaction, Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA)were compared between the two groups.Results Before nursing, there were no statistically significant differences in CGI-SI, HAMD, HAMA scores, estradiol, progesterone levels and nursing satisfaction between the two groups (P＞0.05).After nursing, CGI-SI, HAMD, HAMA scores, estradiol and progesterone levels in the two groups were lower those before nursing, the CGI-SI, HAMD, HAMA scores, estradiol and progesterone levels of the study group were lower than those of the control group, the differences were statistically significant (P＜0.05).After nursing, the total nursing satisfaction of the study group was 96.7%, higher than that of the control group(80.0%), with statistical difference (P＜0.05).Conclusion Combined with psychological intervention in the nursing of postpartum depression patients can effectively improve the negative mood of patients, and abnormal hormone levels, significantly improve nursing satisfaction.Therefore, the nursing model is worthy of clinical promotion and application. 2021 Vol. 28 (10): 216-219 [Abstract] ( 35 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 220 Application effect of exercise rehabilitation nursing in patients with cerebral infarction hemiplegia CHEN Juan Objective To explore the application effect of exercise rehabilitation nursing in patients with cerebral infarction hemiplegia.Methods A total of 60 patients with cerebral infarction hemiplegia admitted to Fuzhou First People′s Hospital, Jiangxi Province from May 2018 to April 2020 were selected and divided into the control group and the observation group according to the order of their admission, 30 cases in each group.Patients in the control group were implemented with routine nursing, and in the observation group, patients were added with exercise rehabilitation nursing.The motor function rating scale (Fugl-Meyer) score, Barthel index and muscle strength of the two groups were compared before and after nursing intervention.Results There were no significant differences in Fugl-Meyer score and Barthel index between the two groups before intervention (P ＞0.05).After intervention, the Fugl-Meyer score and Barthel index of the observation group were higher than those of the control group, with statistical differences (P＜0.05).There was no statistically significant difference in muscle strength classification between the two groups before intervention (P＞0.05).After the intervention, the muscle strength classification in observation group was better than that of the control group, with statistical difference (P＜0.05).Conclusion The exercise rehabilitation nursing can markedly improve the limb motor function of patients with cerebral infarction hemiplegia and increase muscle strength, which is recommended for promotion. 2021 Vol. 28 (10): 220-222 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 223 Effect of predictive nursing on suicidal behavior of patients with schizophrenia XU Cai-xia Objective To explore the effect of predictive nursing on suicidal behavior in schizophrenic patients.Methods A total of 80 patients with schizophrenia treated in Shangrao Third People′s Hospital, Jiangxi Province from January 2017 to April 2020 were selected as the research objects.According to different nursing methods, they were divided into the control group (n=39) and the observation group (n=41).Patients in the control group were given routine nursing intervention, and patients in the observation group were given routine nursing+predictive nursing intervention，all patients were intervened for 4 weeks.The incidence of suicidal behavior and the behavioral activity rating scale(BARS) before intervention and 4 weeks after intervention and the social function rating scale (SSPI) scores of inpatients with mental illness were compared between the two groups.Results The incidence of suicide in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).Before the intervention, the BARS scores of the two groups were compared, the difference was not statistically significant (P＞0.05); after 4 weeks of intervention, the BARS scores in the two groups were lower than those before intervention, and the BARS score of the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05).Before intervention, the scores of daily living ability, motility and interaction, and social skills of the two groups were compared, the differences were not statistically significant (P＞0.05); after 4 weeks of intervention, the scores of activities of daily living, motility and communication, and social skills in the two groups were higher than those before intervention, and the scores of daily living ability, motility and communication, and social skills of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05).Conclusion Implementing predictive care among schizophrenic patients can effectively reduce the incidence of suicidal behavior,can effectively reduce behavioral impulse symptoms and improve social function. 2021 Vol. 28 (10): 223-225 [Abstract] ( 44 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 226 Application of dual-link synergetic psychological nursing in patients with acute calculous cholecystitis during the perioperative period ZHAN Yong-hong Objective To explore the application of dual-link synergetic psychological nursing in patients with acute calculous cholecystitis during the perioperative period.Methods The clinical data of 60 patients with acute calculous cholecystitis who underwent surgeries in Dexing People′s Hospital, Jiangxi Province from July 2019 to January 2020 were retrospectively analyzed.The clinical data of 31 patients who received conventional nursing were classified as the control group, and the clinical data of 29 patients who were provided with conventional nursing+dual-link synergetic psychological nursing were classified as the observation group.The psychological status, complications, and quality of life were compared between the two groups.Results After one week of nursing, the scores of the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) of the observation group were lower than those of the control group,with statistical differences (P＜0.05).The total incidence of complications in the observation group was lower than that in the control group, with statistical difference (P＜0.05).After one week of nursing, the quality of life scale (QOL) score of the observation group was higher than that of the control group, with statistical difference (P＜0.05).Conclusion Dual-link synergetic psychological nursing can improve the anxiety and depression of patients with acute calculous cholecystitis, reduce the incidence of complications, and improve their QOL scores. 2021 Vol. 28 (10): 226-228 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 229 Application of whole course nursing in reducing the risk of medical care for patients with severe heart failure CHEN Xiao-wei； HUANG Xiu-xia； FU Yin-zhu Objective To observe the application effect of whole course nursing in reducing the risk of medical care of patients with severe heart failure (SHF).Methods From December 2017 to December 2019, 120 patients with SHF who were treated in Puning Overseas Chinese Hospital, Guangdong Province were selected and divided into the control group and the experimental group according to the random number table method, 60 cases in each group.General nursing intervention was given to the control group, and the whole process nursing intervention was given to the experimental group.The nursing satisfaction, the improvement of cardiac function index before and after nursing and the incidence of risk events were compared between the two groups.Results The total satisfaction of the experimental group after nursing was higher than that of the control group, the difference was statistically significant (P＜0.05).The left ventricular ejection fraction (LVEF) value of the experimental group after nursing was higher than that of the control group, the difference was statistically significant (P＜0.05); the left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD) and urinary natriuretic peptide (BNP) value of the experimental group after nursing were lower than those of the control group, the differences were statistically significant (P＜0.05).The total incidence of risk events after nursing in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion The whole course nursing for the patients with SHF can significantly reduce the risk of medical care, improve the satisfaction of nursing and improve the indexes of patients′ heart function,which is worth popularizing. 2021 Vol. 28 (10): 229-231转234 [Abstract] ( 37 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 232 Effect of continuous nursing after discharge on quality of life in patients with severe burns based on WeChat platform CAO Xiao-xia； YI Xian-feng； SHANG Yan-ping； XU Yan-zi ；XU Zhao； GUO Xiu-lan Objective To explore the effect of continuous nursing after discharge on WeChat platform on the quality of life of patients with severe burns.Methods A total of 60 discharged patients with severe burns treated in Guangdong Work Injury Rehabilitation Hospital form January 2018 to April 2019 were selected as research objects, which were divided into the control group (n=30) and the observation group (n=30) according to random number table method.The control group received monthly routine telephone follow-up visits.The control group received monthly telephone follow-up visits The observation group received continuous nursing after discharge based on WeChat platform.Results The quality of life score of the observation group after intervention was higher than that of the control group, the difference was statistically significant (P＜0.05).The self-efficacy level of the two groups had no difference before intervention (P＞0.05), and the self-efficacy level of the observation group after intervention was (27.07±6.20) points, which was higher than that of the control group of (21.67±6.82) points, and the difference was statistically significant (P＜0.05).Conclusion Continuing nursing intervention on patients with severe burns using the WeChat platform can significantly improve patients′ quality of life and self-efficacy level.It has positive clinical use and promotion value. 2021 Vol. 28 (10): 232-234 [Abstract] ( 44 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 235 Influence of clinical nursing pathway on complications of maintenance hemodialysis HUANG Yang Objective To explore the effect of clinical nursing pathway on complications of maintenance hemodialysis(MHD).Methods A total of 75 patients with MHD treated in Xiaogan Central Hospital, Hubei Province from June 2018 to December 2019 were selected as the research objects, and they were divided into the experimental group (40 cases)and the control group (35 cases).The control group was given routine nursing method, and the experimental group was given clinical nursing pathway intervention on the basis of the control group.Both groups were given continuous nursing for 14 days.The complications, nursing compliance, quality of life before and after nursing and nursing satisfaction were compared between the two groups.Results The total incidence of complications in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05).The nursing compliance score of the experimental group was higher than that of the control group, the difference was statistically significant (P＜0.05).The score of quality of life in the experimental group was higher than that in the control group, the difference was statistically significant (P＜0.05).The total satisfaction of clinical nursing in the experimental group was higher than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Clinical nursing pathway intervention can reduce the incidence of complications in MHD patients, and improvement of nursing compliance, quality of life and nursing satisfaction. 2021 Vol. 28 (10): 235-237 [Abstract] ( 40 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 238 Application of thermal insulation nursing in operation of patients with colorectal cancer REN Dong-xu Objective To explore the effect of heat preservation nursing during operation for patients with colorectal cancer (CRC), and to provide reference for clinical intervention.Methods A total of 100 patients with CRC treated in Liaoyang Central Hospital, Liaoning Province from April 2018 to April 2020 were selected as the research objects.They were divided two groups according to random number table method, 50 cease in each group.The control group used conventional nursing intervention, and the study group used thermal nursing intervention on the basis of the control group.The body temperature, stress indicators, surgical conditions and complications of the two groups were compared.Results After anesthesia, the body temperatures of the study group after 1 hour of opening the cavity, 2 hours of opening the cavity and the end of operation were higher than those of the control group, the extubation time, wake up time after operation and time out of the room were shorter than those in the control group, the levels of aldosterone(ALD) and cortisol (COR) 24 hours after surgery were lower than those of the control group, and the total incidence of complications was lower than that of the control group, the differences were statistically significant (P＜0.05).Conclusion The use of thermal insulation nursing during surgery for CRC patients can effectively maintain the patients′ intraoperative body temperature, ensure the smooth progress of the operation, relieve stress response and reduce the incidence of complications.It is worthy of promotion. 2021 Vol. 28 (10): 238-240 [Abstract] ( 38 ) HTML (29 KB)  PDF  (0 KB)  ( 5 )

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