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| Analysis of the relationship between heart failure and B-type brain natriuretic peptide in patients with hemodialysis |
| LIU Yan-li CHEN Qing-ping |
| Department of Nephrology, Pingxiang People′s Hospital, Jiangxi Province, Pingxiang 337000, China |
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Abstract Objective To analyze the relationship between heart failure (HF) and B-type brain natriuretic peptide(BNP) in patients with hemodialysis.Methods From January 2019 to August 2020, a total of 60 new found of patients with hemodialysis in Pingxiang People′s Hospital were selected, according to the left ventricular ejection fraction(LVEF) levels, patients with HF (LVEF＜50%) were classified as the observation group (30 cases), and those without HF(LVEF≥50%) were classified as the control group (30 cases).Both groups were tested for LVEF, BNP levels after admission,the observation group was received conventional anti-HF treatment and integrated treatment of chronic renal failure,and the control group was received conventional hemodialysis and integrated treatment of chronic kidney disease.LVEF levels of the two groups at admission were recorded; the BNP levels of the two groups at admission and after intervention treatment were compared.The relationship between LVEF and BNP levels in patients with hemodialysis were analyzed,and a receiver operating curve(ROC)curve was drawn to analyze the predictive value of BNP levels for HF in patients with hemodialysis.Results LVEF level of observation group at admission was lower than that of control group, the difference was statistically significant(P＜0.05);the BNP levels of observation group at admission and after treatment were higher than those of control group, and the BNP level of the observation group after treatment was lower than that at admission, the differences were statistically significant (P＜0.05); the BNP level after treatment in the control group was compared with that at admission, the difference was not statistically significant (P＞0.05).Correlation analysis showed that LVEF level was negatively correlated with BNP level at admission (r=-0.806，P＜0.001).The ROC curve was drawn and analyzed that the BNP level predicted the area under the curve of HF in patients with hemodialysis was 0.952,which had high predictive value, the corresponding optimal threshold was 222.35 ng/dL, the sensitivity was 96.70%,and the specificity was 46.70%.Conclusion The level of BNP can effectively judge the progress of HF in patients with hemodialysis.High level of BNP is an influencing factor of HF in patients with hemodialysis.Clinical interventions can be made in advance based on the level of BNP to improve the prognosis of patients.It is worthy of clinical promotion.
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