尼可地尔联合单硝酸异山梨酯对急性心肌梗死介入治疗患者心肌微循环灌注的影响

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Abstract Objective To investigate the efficacy and safety of Nicorandil combined with Isosorbide Mononitrate in patients with acute myocardial infarction undergoing interventional therapy.Methods A total of 86 patients with acute myocardial infarction admitted to the Second Nanning People′s Hospital from January 2018 to January 2020 were selected as the research subjects.According to random number table method, they were divided into the control group and the observation group, with 43 cases in each group.The control group received Isosorbide Mononitrate after interventional therapy, and the observation group was additively treated with Nicordil at admission and after interventional therapy.Cardiac function, myocardial microcirculation perfusion, serological indexes and the incidence of adverse reactions were compared between the two groups.Results There was no statistically significant difference in the cardiac function between the two groups before operation(P＞0.05).At 30 days after surgery, the left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) of the two groups were lower than those before surgery, the left ventricular ejection fraction (LVEF)was higher than that before surgery, and the differences were statistically significant (P＜0.05).At 30 days after surgery,the LVEDD and LVESD in the observation group were (43.16±3.82) and (34.67±3.81) mm, lower than (47.65±3.98) and(38.28±3.94) mm in the control group, the LVEF was (54.41±4.62)%, higher than (50.39±4.53)% in the control group,and the differences were statistically significant (P＜0.05).The sum of capillary cross-sectional area, blood flow velocity and myocardial blood flow in observation group were (15.42±1.75) cm2, (0.79±0.16) cm/s and (12.03±1.53) L/min, which were higher than (13.95±1.68) cm2, (0.72±0.14) cm/s and (10.21±1.42) L/min in control group, and the differences were statistically significant (P＜0.05).There were no statistically significant differences in preoperative serum indexes between the two groups before operation (P＞0.05).The 24 h postoperative levels of troponin I (cTnI) and N-terminal probrain natriuretic peptide (NT-proBNP) were higher than those before operation in the two groups, and the differences were statistically significant (P＜0.05).The 24 h postoperative levels of cTnI and NT-proBNP in the observation group were (60.14±7.25) μg/L and (769.35±70.16) ng/L, which were lower than (69.43±7.36) μg/L and (903.41±81.53) ng/L in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant differences in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Nicorandil combined with Isosorbide Mononitrate improves myocardial microcirculation perfusion in patients undergoing interventional therapy for acute myocardial infarction, which accelerates the recovery of cardiac function and reduces the levels of cTnI and NT-proBNP.It is safe and reliable.

Key words： Acute myocardial infarction Interventional therapy Nicorandil Isosorbide Mononitrate Myocardial microcirculation perfusion Adverse reactions

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	Articles by authors
	SONG Qing-hua
	HE Qian
	HU Wen-biao
	LU Yuan-xi
	PAN Qiao-lin
	SU Wen-jian

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SONG Qing-hua,HE Qian,HU Wen-biao, et al. Efficacy of Nicorandil combined with Isosorbide Mononitrate on myocardial microcirculation perfusion in patients with acute myocardial infarction[J]. 中国当代医药, 2021, 28(10): 96-99.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I10/96

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