循环血肿瘤细胞检测在根治性膀胱全切术后评估中的临床研究

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Abstract Objective To investigate the application value of circulating tumor cells (CTC) in the evaluation of radical cystectomy.Methods From June 2018 to October 2019, ninety patients with bladder cancer undergoing radical cystectomy in Pingxiang People′s Hospital were selected as the study group, and ten non tumor patients in Pingxiang People′s Hospital at the same time were selected as the control group.Before operation, 7.5 mL of peripheral venous blood was collected and separated by negative enrichment method.Peripheral CTC was detected by immunofluorescent in situ hybridization (imFISH) detection technology.The relationship between the positive rate of CTC and clinicopathological characteristics of bladder cancer patients, and the relationship between CTC expression level and prognosis of bladder cancer patients were analyzed.Results The positive detection rate of CTC in the study group was higher than that in the control group, the difference was statistically significant (P＜0.05).The CTC positive rate of multiple tumors was higher than that of single tumor, the CTC positive rate of tumor diameter ≥3 cm was higher than that of ＜3 cm, the CTC positive rate of ≥T2 stage was higher than that of ＜T2 stage, the CTC positive rate of high-grade tumors was higher than that of low-grade tumors, the CTC positive rate of recurrent patients was higher than that of non-recurrence patients, and the differences were statistically significant (P＜0.05).The survival curve showed that the survival rate of CTC positive expression was higher than that without CTC positive table, the difference was statistically significant (P＜0.05).Conclusion CTC is closely related to tumor number, tumor diameter, pathological grade, T stage and recurrence of bladder cancer.The expression of CTC is closely related to the prognosis of patients with bladder cancer, which can be used as an independent index to predict the prognosis of bladder cancer.

Key words： Bladder cancer Radical cystectomy Circulating blood tumor cells

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	KANG Xi
	LI qin
	LIU fang

Cite this article:

KANG Xi,LI qin,LIU fang. Clinical study of circulating blood tumor cell detection in the evaluation after radical cystectomy[J]. 中国当代医药, 2021, 28(10): 123-126.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I10/123

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