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Quick Search     Adv Search 2019 Vol. 26, No. 9 Published: 2019-03-28   4 Expression and clinical significance study of Keap1/Nrf2/HIF-1α pathway in cervical cancer PENG Hui；XIAO Ren-bin；WANG Jiang-tao；WEN Zhao-ming； ZHOU Kai-liang；WU Juan Objective To explore the expression and clinical significance of Keap1/Nrf2/HIF-1α pathway in cervical cancer. Methods A total of 40 patients with cervical cancer treated in our hospital from March 2017 to October 2018 were selected as subjects in this study. All the patients were treated by surgery. The lesion tissue and adjacent tissues were removed during the operation,and fresh specimens were obtained.The positive rates of hypoxia-inducible factor-1α(HIF-1α), NF-E2 related factor 2 (Nrf2) and Keap1 in cervical cancer tissues and adjacent tissues were determined by immunohistochemistry. The expression of Keap1/Nrf2/HIF-1α gene pathway was determined by RT-PCR. Results The positive rates of HIF-1α, Nrf2 and Keap1 in cervical cancer tissues were higher than those in adjacent tissues (P＜0.05). Under immunohistochemistry, Nrf2 was mainly expressed in the nucleus of cervical cancer cells, partially in the cytoplasm； while HIF-1α and Keap1 were mainly expressed in the cytoplasm of cervical cancer tissues. The expression of the Keap1/Nrf2/HIF-1α gene pathway was higher in cervical cancer tissues than that in the adjacent tissues (P＜0.05). Conclusion The Keap1/Nrf2/HIF-1α pathway is expressed in cervical cancer and may be involved in the pathogenesis and development of cervical cancer. 2019 Vol. 26 (9): 4-6转25 [Abstract] ( 92 ) HTML (36 KB)  PDF  (0 KB)  ( 15 ) 7 Study on microbial limit test methods of eight kinds of hospital traditional Chinese medicine preparations XIE Kai-biao；CHEN Zhen-yao；QIU Xin-hua； XIE De-qiu；CHEN Hai-yang Objective To stablish the microbial limit test method for eight hospital Chinese materia medica preparations such as Piyangning Lotion, Shenyu Jiechangkang Enema, Zhiloubao Lotion, Fuyanning Lotion, Gouchan Toutongning Capsules, Shangke Quyu Tablets, Shugan Xingqi Capsules, Zhuangyao Jianbu Pills, etc. which contain antibacterial components. Methods According to the methods mentioned under Part Ⅳ “1105, 1106 and 1107” of Version 2015 Chinese Pharmacopoeia, the 8 Chinese materia medica preparations which contain antibacterial components were taken as the research objects, and 3 batches were selected for implementing the microbial limit test. Results The results of the applicability test of the microbial count method suggest that the antibacterial activity can be eliminated by dilution method, which can be determined by plate method or by membrane filtration method. The recovery ratio of the microbial count of both methods was 0.5-2.0. The results of the suitability test of the control bacteria showed that all the bacteriostatic components were positive after dilution treatment. Conclusion Establishing method is correct and feasible, which could be used for microbial limit test of eight hospital Chinese materia medica preparations. 2019 Vol. 26 (9): 7-12 [Abstract] ( 79 ) HTML (56 KB)  PDF  (0 KB)  ( 10 ) 13 Curative effect of single port laparoscopic ventriculoperitoneal shunt with conventional instruments ZOU Hai-bo；FEI Fan；LUO Lan-yun；WANG Qi；WANG Guan；LAI Chun-you；ZHANG Yu；HUANG Xiao-lun  Objective To investigate the curative effects and applications of single port laparoscopic ventriculoperitoneal shunt with conventional instruments. Methods From July 2013 to November 2016, 138 patients of ventriculoperitoneal shunt operation in our hospital were selected as the subjects, and divided into single portlaparoscopic surgery group (66 cases)and traditional open surgery group(72 cases)according to the different types of surgery.The single port laparoscopic surgery group was assisted by conventional single port laparoscopy, while the traditional open surgery group was assisted by traditional laparotomy. The abdominal operation time, intraoperative blood loss, postoperative hospital stay, postoperative pain score, tube blockage rate, incision length and postoperative complications rate were compared. Results All the operations were successfully completed in two groups. The operative time of the single port laparoscopic group was significantly shorter than that of the traditional open surgery group, the intraoperative blood loss of the single port laparoscopic group was less than that of the traditional open surgery group, and the incision length of the single port laparoscopic group was significantly shorter than that of the traditional open surgery group, the differences were statistically significant (P＜0.05). The postoperative anal exhaust time of patients in the single port laparoscopic group was significantly shorter than that in the traditional open surgery group, and the postoperative shunt blockage rate of the single port laparoscopic group was lower than that in the traditional open surgery group, and the differences were statistically significant (P＜0.05). There was no significant difference between the two groups in terms of pain score at 6 h and 24 h after surgery, rate of use of painkillers, incision complications and hospitalization (P＞0.05).Conclusion Single port laparoscopic ventriculoperitoneal shunt with conventional instruments is safe, effective, feasible,better cosmetic, and should be promoted. 2019 Vol. 26 (9): 13-17 [Abstract] ( 108 ) HTML (44 KB)  PDF  (0 KB)  ( 11 ) 18 Short-term prognosis and risk factors of chronic obstructive pulmonary disease complicated with pulmonary embolism LIU Pian；ZHUO Yu-juan Objective To study the short-term prognosis andrisk factors for acute pulmonary embolism (PE)in patients with chronic obstructive pulmonary disease (COPD), to improve the early diagnosis rate of COPD with PE. Methods Forty-eight patients with COPD complicated with PE (as embolization group) and 50 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) (as control group) admitted to our hospital from January 2014 to July 2018 were selected as subjects for the study. The short-term prognosis and risk factors of COPD with PE were analyzed retrospectively. Results The bed time which was more than 3 days, lower limb asymmetric edema, chest pain, mortality and D-dimer, arterial partial pressure of oxygen (PaO2) and N-terminal brain natriuretic peptide (NT-proBNP) were compared between the two groups, the differences were statistically significant (P＜0.05). In the embolization group, the patients who died (n=9) of hypersensitive troponin T (hs-TnT) and NT-proBNP were higher than those of the survival(n=39), the differences were statistically significant (P＜0.05). Logistic regression analysis results showed that bed time≥3 d, asymmetric edema of lower limbs, D-dimer ≥2.0 μg/ml, PaO2＜60 mmHg and NT-proBNP ≥1200 pg/ml were risk factors for COPD with PE (P＜0.05). Conclusion Patients with COPD have ahigher incidence of PE if they have the risk factors of immobilization ≥3 days, asymmetric edema of lower limbs, D-dimer ≥2.0 μg/ml or PaO2 ＜60 mmHg,and cardiac dysfunction. If the levels of hs-TnT and NT-proBNP are significantly increased, their short-term prognosis is poor. 2019 Vol. 26 (9): 18-21 [Abstract] ( 100 ) HTML (41 KB)  PDF  (0 KB)  ( 13 ) 22 Research progress on the effects of planting and processing on chemical constituents of Angelica Sinensis SUN Min；MA Qing-lin；LIU Feng-lin；REN Yuan This paper refers to the literature on the planting and processing of Angelica Sinensis after 2010, the contents of volatile oil, polysaccharide and ferulic acid in Angelica Sinensis are used as evaluation indexes, the effects of different producing areas, harvesting time and processing on the contents of volatile oil, polysaccharide and ferulic acid in Angelica Sinensis are reviewed and discussed, it provides a theoretical basis for further clarifying the authenticity of Angelica Sinensis. 2019 Vol. 26 (9): 22-25 [Abstract] ( 79 ) HTML (37 KB)  PDF  (0 KB)  ( 12 ) 26 Research progress in the intervention effect of traditional chinese medicine on targeted therapy for non-small cell lung cancer FAN Rui；LI He-gen Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors in China. Surgical treatment is the first choice for early and middle stage patients. Postoperative adjuvant radiotherapy and chemotherapy can prolong the survival time, but its efficacy has entered a plateau period. Molecular targeting therapy has made some progress in the treatment of advanced lung cancer, but targeting therapy has the dual characteristics of good effect and easy drug resistance, and can cause side effects such as diarrhea, rash and so on. The adjuvant treatment of traditional Chinese medicine can delay the drug resistance time of targeting drugs, efficacy enhancing and toxicity reducing of targeting therapy, and play the role of synergy and attenuation. In this review, by discussing the research process of targeted therapy and combining with the research progress of traditional Chinese medicine, we propose that TCM intervention can improve the clinical therapeutic effect from the perspective of integration of traditional Chinese medicine and Western medicine, and provide a theoretical basis for the treatment of diseases. 2019 Vol. 26 (9): 26-29转33 [Abstract] ( 107 ) HTML (42 KB)  PDF  (0 KB)  ( 9 ) 30 Research progress on the role of IL-22 in connective tissue diseases WU Sheng-xia；ZOU Ni Th17 and Th22 cells are two new subsets of Th cells, Th22 cells mainly secrete cytokines such as interleukin-22 (IL-22), interleukin-13 (IL-13) and tumor necrosis factor-α (TNF-α), the most important of these is IL-22.IL-22 is a member of the interleukin-10 (IL-10) cytokine family, it plays different roles in the occurrence and development of autoimmune diseases, tumors, infections and so on. Connective tissue disease is a group of autoimmune diseases involving bone, joint, muscle, blood vessel, ligament and other connective tissues. The etiology of CTD is still unclear. As a new cytokine, IL-22 has attracted much attention in the pathogenesis of connective tissue diseases, such as Sjogren′s syndrome, rheumatoid arthritis, systemic lupus erythematosus and ankylosing spondylitis. This article reviews the research status of IL-22 in common connective tissue diseases. 2019 Vol. 26 (9): 30-33 [Abstract] ( 107 ) HTML (39 KB)  PDF  (0 KB)  ( 12 ) 34 Hypotensive effect study of Oroxylum indicum (L.) Vent on SHR rats HE Xiao-Qun；PAN Yong；LI Tian-Zi；LIANG Ye；FENG Xue-ping  Objective To discuss the hypotensive effect of Oroxylum indicum (L.) Vent on spontaneously hypertensive rats (SHR) rats. Methods All of 20 SHR rats were selected and they were divided into model group, Benazepril group,high-dosage group of Oroxylum indicum (L.) Vent group and low-dosage group of Oroxylum indicum (L.) Vent, 5 cases in each group. 5 male Wistar rats were selected as blank control group. Model group was given 2 ml/d of normal saline,Benazepril group was given 10 mg/(kg·d) of Benazepril, high-dosage group of Oroxylum indicum (L.) Vent group was given 2 ml/d of Oroxylum indicum (L.) Vent extraction solution, low-dosage group of Oroxylum indicum (L.) Vent was given 0.5 ml/d of Oroxylum indicum (L.) Vent, blank control group was given 2 ml/d of normal saline, and they were treated with intragastric administration, once a day for 2 months. The arterial systolic blood pressure (SBP) and superoxide dismutase (SOD) in serum of rats were measured before and after treatment. Results The SBP of Benazepril group and low-dosage group of Oroxylum indicum (L.) Vent after 30 days administration were lower than those before administration, and the differences were statistically significant (P＜0.05), but there were no significant differences in blank control group, model group and high dose group compared with before administration (P＞0.05). SBP of blank control group and low-dosage group of Oroxylum indicum (L.) Vent after 30 days administration after 30 days administration were lower than those of model group, and the differences were statistically significant (P＜0.05). SBP in lowdosage group of Oroxylum indicum (L.) Vent and highdosage group of Oroxylum indicum (L.) Vent after 60 days administration were lower than those before administration,and the differences were statistically significant (P＜0.05), but there was no significant differences between blank control group, model group and Benazepril group compared with those before administration (P＞0.05). SBP of blank control group and low-dosage group of Oroxylum indicum (L.) Vent after 60 days administration were lower than those of model group, and the differences were statistically significant (P＜0.05). The serum SOD content in Benazepril group and high-dosage group of Oroxylum indicum (L.) Vent were higher than those before administration, and the differences were statistically significant (P＜0.05), but there were no significant differences between blank control group,model group and low-dosage group of Oroxylum indicum (L.) Vent compoared with before administration (P＞0.05). The serum SOD content in Benazepril group after 60 days administration were higher than that in model group, and the difference was statistically significant (P＜0.05). The serum SOD content in Benazepril group and high-dosage group of Oroxylum indicum (L.) Vent after 60 days administration were higher than those in model group, and the differences were statistically significant (P＜0.05). Conclusion Oroxylum indicum (L.) Vent has antihypertensive effect on SHR rats,and the effect is obvious. 2019 Vol. 26 (9): 34-37 [Abstract] ( 90 ) HTML (38 KB)  PDF  (0 KB)  ( 12 ) 38 The effect of Pirfenidone combined with Nintedanib treating pulmonary fibrosis in mice WANG Xue；LI Qiao-ling；GAO Yun-yun；DENG Wen Objective To explore the effect and method of Pirfenidone combined with Nintedanib treating pulmonary fibrosis in mice. Methods All of 90 male Kunming mice aged 6-8 weeks were selected, After 1 week of adaptive feeding, and among them, 10 mice were randomly selected as control group, and the other 80 mice were treated with Bleomycin to establish pulmonary fibrosis model. The pulmonary function of the mice was measured by Buxco animal pulmonary function analysis system. The Penh value increased to more than 1.5, and the model was established successfully. 40 model mice were selected randomly from successful mice modeling and randomly divided into control group (0.1 ml normal saline, 3 times a day), Pirfenidone group (400 mg/kg, 3 times a day), Nintedanib group (150 mg/kg,2 times a day), Pirfenidone (400 mg/kg, 3 times a day) combined with Nintedanib group (150 mg/kg, 2 times a day).The mice were gavaged for 3 weeks. Penh value was measured using the above-mentioned method. Then the mice were sacrificed after anaesthetized. The alveolar lavage fluid was collected and centrifuged, then the cells were obtained. After Swiss-Giemsa staining, the white cells in alveolar lavage fluid of mice were counted under inverted microscope.Results A total of 80 mice were modeled and 50 mice (62.5%) were successfully modeled. After treatment, the Penh value in Pirfenidone group combined with Nintedanib group were lower than those in Pirfenidone group (P＜0.05),Nintedanib group (P＜0.05) and control group (P＜0.01). The leukocyte of Pirfenidone combined with Nintedanib group was fewer than that of Pirfenidone group (P＜0.05), Nintedanib group (P＜0.05) and control group (P＜0.01). Conclusion The therapeutic effect of Pirfenidone combined with Nintedanib is the best, which lays a foundation for the clinical use of this method in the treatment of pulmonary fibrosis. 2019 Vol. 26 (9): 38-40 [Abstract] ( 102 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 41 Clinical effect of Lianbizhi Injection combined with Ceftriaxone Sodium and Tazobactam Sodium in the treatment of senile pneumonia GUO Yu-mei；GENG Li-li； SHU Jiao-jie；ZHANG Yun；XU Xian-nan；ZANG Shi-guo；LIU Hao Objective To investigate the clinica effect of Lianbizhi Injection combined with Ceftriaxone Sodium and Tazobactam Sodium in the treatment of senile pneumonia. Methods A total of 90 elderly patients with pneumonia admitted to our hospital from June 2017 to June 2018 were selected as the study subjects. According to the random number table method, they were divided into the control group (45 cases) and the combined group (45 cases). The control group was treated with Ceftriaxone Sodium and Tazobactam Sodium, the combined group was treated with Lianbizhi Injection and Ceftriaxone Sodium and Tazobactam Sodium. After 2 weeks of treatment, the improvement of symptoms,medication effect and inflammation indicators before and after treatment were compared between the two groups. Results The antipyretic time, cough disappearance time and wheezing time in the combined group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The total effective rate of the combined group was higher than that of the control group , and the difference was statistically significant (P＜0.05). After treatment, the levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the two groups were lower than those before treatment, and the levels of CRP, TNF-α and IL-6 in the combined group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion On the basis of Ceftriaxone Sodium and Tazobactam Sodium combined with Lianbizhi Injection can significantly improve the clinical symptoms and inflammatory indicators of senile pneumonia patients, with good application effect. 2019 Vol. 26 (9): 41-43 [Abstract] ( 109 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 44 Clinical effect of complete disinfection of Iodophor in the prevention of infection after transrectal ultrasound-guided prostatic puncture XIONG Zhi-yong Objective To explore the clinical effect of complete disinfection of Iodophor in the prevention of infection after transrectal ultrasound-guided prostatic puncture. Methods A total of 60 cases of suspected prostate cancer treated with transrectal ultrasound-guided prostatic puncture in our hospital from February 2016 to February 2018 were selected as study objects, and they were divided into the control group (n=30) and the observation group (n=30) according to the disinfection method. The patients in the control group were treated with routine rectal disinfection, the patients in the observation group were given complete rectal disinfection with Iodophor, and the infection rate after operation was compared between the two groups. Results The postoperative infection rate of patients in the observation group was 6.7%, which was significantly lower than that of the control group (30.0%), and the difference was statistically significant (P＜0.05). Conclusion The application of complete disinfection of Iodophor in transrectal ultrasound-guided prostatic puncture can significantly reduce the risk of postoperative infection, which is worthwhile to carry out popularization and application on the basis of in-depth discussion. 2019 Vol. 26 (9): 44-46 [Abstract] ( 93 ) HTML (30 KB)  PDF  (0 KB)  ( 12 ) 47 Efficacy comparison of laparoscopic and open abdominal incisional hernia repair DONG Ling-yi；HUANG Kun-zhai；JIANG Han；ZHANG Si-yu；ZHANG Fu-xing Objective To compare the efficacy of laparoscopic and open incisional hernia repair in patients with abdominal incisional hernia. Methods The clinical data of 61 patients who underwent abdominal incisional hernia surgery in our hospital from February 2011 to January 2016 were retrospectively analyzed. They were divided into the laparoscopic group (30 cases) and the open group (31 cases) according to the surgical approach. The intraoperative bleeding volume, the operation time, the rate of using drainage tube, the postoperative pain (the duration of analgesics use), the first flatus time, the incidence of postoperative complication, the length of postoperative hospital stay, the chronic pain rate and the recurrence rate were compared between the two groups. Results The intraoperative bleeding volume in the laparoscopic group was less than that in the open group, and the rate of using drainage tube in the laparoscopic group was lower than that in the open group, and the length of postoperative hospital stay in the laparoscopic group was shorter than that in the open group, the differences were statistically significant (P＜0.01). However, there were no significant differences in the operation time, the postoperative pain, the first flatus time, the total incidence rate of postoperative complication, the chronic pain rate and the recurrence rate between the two groups (P＞0.05). Conclusion The laparoscopic abdominal incisional hernia repair has the same effect as the open operation, but it has the advantages of minimal invasion and shorter postoperative hospital stay. 2019 Vol. 26 (9): 47-50 [Abstract] ( 88 ) HTML (37 KB)  PDF  (0 KB)  ( 9 ) 51 Clinical effect of single port thoracoscopy in the treatment of patients with spontaneous pneumothorax WU Xuan-qin；CHEN Geng；CHEN Zhong-liang Objective To investigate the clinical effect of single port thoracoscopy in the treatment of patients with spontaneous pneumothorax. Methods The clinical data of 80 patients with spontaneous pneumothorax admitted to our hospital from June 2014 to June 2017 were retrospectively analyzed. They were divided into the single port thoracoscopy group and the traditional thoracoscopy group according to different treatment methods, with 40 cases in each group. The single port thoracoscopy group was treated with single port thoracoscopy for spontaneous pneumothorax patients, while the traditional thoracoscopy group was treated with traditional thoracoscopy for spontaneous pneumothorax patients. The operation-related indicators, postoperative pain, complication and recurrence of pneumothorax at 12 months after operation were compared between the two groups. Results There were no significant differences between the two groups in the amount of intraoperative hemorrhage, operation time, duration of thoracic tube indwelling, postoperative hospital stay, postoperative 12 months recurrence rate of pneumothorax on the operative side (P＞0.05). The visual analogue scale (VAS) scores at 24, 72 h and 1 week after operation in the single-hole thoracoscopic group were lower than those in the traditional thoracoscopic group, with significant differences (P＜0.05). In the single port thoracoscopy group, no puncture hole was added and no complications such as conversion to thoracotomy or massive hemorrhage were found. Conclusion Compared with the traditional thoracoscopic surgery, the single port thoracoscopy has the advantages of reliable efficacy and safety, which can reduce postoperative pain, with high clinical value. 2019 Vol. 26 (9): 51-53 [Abstract] ( 112 ) HTML (30 KB)  PDF  (0 KB)  ( 13 ) 54 Therapeutic effect of Reduced Glutathione on acute kidney injury in patients with sepsis ZHANG Lin；BAI Li  Objective To investigate the therapeutic effect of Reduced Glutathione on acute kidney injury (AKI) in septic patients. Methods From December 2014 to December 2017, a total of 80 patients with sepsis complicated with AKI were selected as objects. According to the random number table, all the patients were divided into the observation group (40 cases) and the control group (40 cases). The control group was treated with conventional comprehensive therapy, while the observation group was treated with Reduced Glutathione on the basis of routine comprehensive therapy.The levels of serum creatinine (SCr), blood urea nitrogen (BUN), C reactive protein (CRP) and acute physiology and chronic health status scores (APACHⅡscore) were compared between the two groups. Results The CRP level, APACHEⅡscore, blood SCr and BUN of the two groups were significantly lower than those of the control group at 3 and 7 days after treatment, and the above indexes of the observation group were significantly lower than those of the control group at 3 and 7 days after treatment, and the differences were statistically significant (P＜0.05). Conclusion Reduced Glutathione can alleviate AKI caused by sepsis and improve the patient′s condition. 2019 Vol. 26 (9): 54-56转60 [Abstract] ( 81 ) HTML (36 KB)  PDF  (0 KB)  ( 13 ) 57 Clinical characteristics and related factors analysis of Crohn′s disease with perianal lesions LI Hao；WANG Qiao-min； LI Ming-tao；ZHU Lin-lin Objective To explore the clinical characteristics of perianal Crohn′s disease and the related factors of perianal lesions. Methods The clinical data of 90 patients with Crohn′s disease hospitalized in the Department of Gastroenterology of Anhui Provincial Hospital (Affiliated Provincial Hospital of Anhui Medical University) from January 2013 to December 2017 were retrospectively analyzed. The patients were divided into the perianal lesions group (63 cases) and the non-perianal lesions group (27 cases) according to whether there were perianal lesions or not. The clinical data of patients with perianal lesions were analyzed and compared with those and without perianal lesions, and the indexes such as sex, age, smoking history, location of disease, disease type, nutritional status, Crohn′s disease activity index (CDAI) score of the two groups were included in statistical analysis to analyze the related factors of perianal lesions. Results There were no significant differences in gender, age, nutrition status, CDAI score between the two groups(P＞0.05), but there were significant differences in smoking, location of disease and type of disease between the two groups (P＜0.05). Smoking and location were independent risk factors for perianal lesions of Crohn′s disease (P＜0.05).Conclusion Smoking and the location of disease are important factors affecting the occurrence of perianal lesions in Crohn′s disease. More active intervention will lead to a greater improvement in the quality of life of patients. 2019 Vol. 26 (9): 57-60 [Abstract] ( 91 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 61 Application effect of adjustable suture on scleral flap in patients undergoing trabeculectomy YANG Ling；QU Zheng-peng Objective To investigate the influence of adjustable suture suturing scleral flap on postoperative intraocular pressure in patients undergoing trabeculectomy. Methods A total of 110 patients with chronic angle-closure glaucoma who were treated at Binhai Hospital of Yingkou Aier Eye Hospital from February to September in 2018 were enrolled.They were divided into the control group and the observation group according to a random number table method, 55 cases in each group. The control group was given non-adjustable suture, and the observation group was given adjustable suture.The incidence of shallow anterior chamber, the surgical success rate, the intraocular pressure index in seven days after surgery, and the intraocular pressure index after two months in the two groups were compared. Results After treatment,the incidence of shallow anterior chamber in the observation group was 5.45%, which was much lower than that in the control group accounting for 23.64%, with statistical difference (P＜0.05). The surgical success rate of the observation group was 96.36%, which was significantly higher than that of the control group accounting for 70.91%, with significant difference (P＜0.05). The intraocular pressure of the observation group was lower than that of the control group at 7 days after operation, with statistical difference (P＜0.05). The intraocular pressure at 2 months after surgery in the observation group was lower than that of the control group, with statistical significance (P＜0.05). Conclusion The adjustable suture can effectively improve the prognosis of patients with chronic angle-closure glaucoma, and it is worthy of promotion and application. 2019 Vol. 26 (9): 61-63 [Abstract] ( 78 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 64 Influence of Buchang Naoxintong Capsules and Nimodipine on neurotrophic status and neurotrophic degree of patients with cerebral hemorrhage in recovery period MA Heng-man Objective To investigate the influence of Buchang Naoxintong Capsules combined with Nimodipine on neurotrophic status and neurological injury in patients with cerebral hemorrhage in convalescent stage. Methods A total of 176 patients with cerebral hemorrhage in convalescent period from January 2017 to January 2018 in our hospital were selected as the research objects. According to the principle of randomization, double blindness and control, they were divided into the observation group (88 cases) and the control group (88 cases). The observation group was treated with Buchang Naoxintong Capsules combined with Nimodipine, while the control group was treated with Nimodipine. The curative effect, serum neurotrophic status index (neurotrophic factor [NGF], brain-derived neurotrophic factor [BDNF],insulin-like growth factor-1 [IGF-1], insulin-like growth factor-2 [IGF-2]) and the degree of nerve injury were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, with statistical significance (P ＜0.05). There was no significant difference in neurological deficit score(NHISS) between the two groups (P＞0.05). The NHISS score of the observation group after treatment was lower than that of the control group, with statistical significance (P＜0.05). There was no significant difference in the contents of NGF, BDNF, IGF-1 and IGF-2 between the two groups before treatment (P＞0.05). After treatment, the contents of NGF, BDNF, IGF-1 and IGF-2 in the observation group increased significantly and were higher than those in the control group (P＜0.05). Conclusion Buchang Naoxintong capsule combined with Nimodipine can not only improve the therapeutic effect to some extent, but also promote the improvement of neurotrophic status and reduce neurological deficits in convalescent patients with cerebral hemorrhage. The effect is remarkable and worthy of clinical application. 2019 Vol. 26 (9): 64-66 [Abstract] ( 114 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 67 Analysis of the effect of Metoprolol combined with Trimetazidine in the treatment of heart failure of coronary heart disease YU Jie Objective To investigate the clinical effect of Metoprolol combined with Trimetazidine in the treatment of heart failure of coronary heart disease. Methods A total of 60 patients with heart failure of coronary heart disease admitted to our hospital from January 2015 to January 2018 were selected and divided into the control group and the observation group according to random lottery, 30 cases in each group. Patients in the control group were given routine treatment, while patients in the observation group were given Metoprolol combined with Trimetazidine. The clinical efficacy, left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and left ventricular end systolic diameter (LVESD) were measured and observed before and after treatment in the two groups. Results The clinical total effective rate in the observation group was 93.33%, which was significantly higher than that in the control group (70.00%), and the difference was statistically significant (P＜0.05). Before treatment, there were no significant differences in LVEDD, LVEF and LVESD between the two groups (P＞0.05). After treatment, the level of LVEF of the observation group was significantly higher than that before treatment and the control group, while the level of LVEDD and LVESD of the observation group were significantly lower than those before treatment and the control group, and the difference was statistically significant (P＜0.05). Conclusion Metoprolol combined with Trimetazidine in the treatment of heart failure of coronary heart disease can effectively improve the patient′s heart function, the clinical effect is ideal. 2019 Vol. 26 (9): 67-69 [Abstract] ( 84 ) HTML (29 KB)  PDF  (0 KB)  ( 10 ) 70 Expressions and significances of estrogen receptor, progesterone recetor,P-glycoprotein, glutathione-s-transferases-π, P-glycoprotein Ⅱin breast cancer YAN Xia；CAI Li ；TANG Hai-xu； WU Ping Objective To explore the expression of estrogen receptor (ER), progesterone recetor (PR), P-glycoprotein(P-gp), glutathione-s-transferases π (GST-π) and P-glycoprotein Ⅱ (Topo Ⅱ) in breast cancer. Methods A total of 91 cases of specimens of breast cancer diagnosed by pathology after surgical excision in Huai′an Maternal and Child Health Hospital from September 2010 to January 2014 were selected. The expression of ER, PR, GST-π, P-gP, TopoⅡin 91 patients from breast cancer tissues were detected by immunohistochemistry technique. Results The expression of ER, PR, GST-π, Topo Ⅱwere significantly associated with histological grades, there existed correlation between Topo Ⅱand lympnode metastasis, P-gP expression was significantly associated with tumor size. The expression of ER was positively correlated with the expression of PR (r=0.637, P=0.000). Conclusion The detection of the expression of ER, PR, GST-π, P-gP, Topo Ⅱhave important meaning for assessing the prognosis of patients with breast cancer and chemtherapy options. 2019 Vol. 26 (9): 70-72 [Abstract] ( 87 ) HTML (29 KB)  PDF  (0 KB)  ( 16 ) 73 Clinical effect of local injection combined with bronchoalveolar lavage in the treatment of bronchiectasis with drug-resistant infection FEI Zong-bao Objective To investigate the clinical efficacy of local injection combined with bronchoalveolar lavage in the treatment of bronchiectasis with drug-resistant infection. Methods A total of 136 patients with bronchiectasis infected with drug-resistant bacteria were enrolled in our hospital from December 2015 to November 2018. The patients were divided into the observation group (68 cases) and the control group (68 cases) according to the random number table method. The observation group was treated with local injection combined with bronchoalveolar lavage, and the control group was treated with bronchoalveolar lavage. The total effective rate, length of hospital stay, normal blood test time,length of clinical symptoms disappeared, arterial blood of carbon dioxide partial pressure (PaCO2) and arterial oxygen partial pressure (PaO2) indicators were compared between the two groups. Results The total clinical effective rate of the observation group was significantly higher than that of the control group, with significant difference (P＜0.05). The length of hospital stay, the normal period of blood routine recovery and the length of clinical symptoms disappeared in the observation group were shorter than those in the control group, the difference was statistically significant (P＜0.05).The PaCO2 index of the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05). The PaO2 index of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Local injection combined with bronchoalveolar lavage can effectively improve the prognosis of patients with bronchiectasis, and the clinical value is higher. 2019 Vol. 26 (9): 73-75 [Abstract] ( 93 ) HTML (35 KB)  PDF  (0 KB)  ( 10 ) 76 Effect comparative analysis of different doses of glucocorticoids in the treatment of systemic lupus erythematosus CHEN Bo ；LIANG Jie Objective To compare the effects of different doses of glucocorticoids in the treatment of systemic lupus erythematosus. Methods A total of 65 patients with systemic lupus erythematosus in our hospital from January 2013 to December 2017 were selected. According to the random number table method, they were divided into the control group(32 cases) and the observation group (33 cases). The control group was treated with small dose of glucocorticoid, while the observation group was treated with large dose of glucocorticoid. The clinical efficacy, the level of serum parathyroid hormone (PTH), bone mineral density (BMD), bone metabolism index, adverse reaction occurrence, and bone injury rate of the two groups were compared. Results The total clinical effectiveness rate, PTH level and bone injury rate in the observation group were all higher than those in the control group, with statistical significance (P＜0.05). The triangular BMD and bone-specific alkaline phosphatase in the observation group after treatment were lower than those in the control group, with statistical significance (P＜0.05). Conclusion The use of high-dose glucocorticoids in the treatment of systemic lupus erythematosus obtains a better effect compared with that in a small dose, which can improve bone metabolism, but is prone to bone damage. Therefore, it is necessary to choose a reasonable glucocorticoid with the consideration of specific clinical conditions. 2019 Vol. 26 (9): 76-78 [Abstract] ( 82 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 79 Clinical significance of detection of serum lipid and uric acid levels in non-alcoholic simple fatty liver disease DUAN Hui-chun ；PU Hun-yun Objective To explore the clinical significance of detection of serum lipid and uric acid levels in non-alcoholic simple fatty liver (SFL) disease. Methods A total of 198 cases of non-alcoholic SFL patients with outpatients and inpatients from October 2016 to October 2018 were selected as the experimental group, and 68 cases of healthy people without fatty liver at the same period were selected as the control group. The characteristics of the two groups were analyzed, and the concentrations of serum lipid and uric acid in the two group were measured. Results The increase proportion of indexes of serum lipid and uric acid in the experimental group were higher than those in the control group,the differences were statistically significant (P＜0.05). Conclusion Serum lipid and uric acid may be involved in the pathogenesis of non-alcoholic SFL disease and have important clinical significance. 2019 Vol. 26 (9): 79-81 [Abstract] ( 97 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 82 Comparison of the effects of negative pressure closed drainage combined with alginate dressing and medical sponge material in the treatment of refractory burn wounds HE Xing；SUN Jia-ju；CHEN Tian-qing；QIU Hai-ping Objective To compare the clinical efficacy of negative pressure closed drainage combined with alginate adjuvant and medical sponge material in the treatment of refractory burn wounds. Methods A total of 60 patients with refractory burn wounds admitted to our hospital from August 2016 to August 2018 were selected and randomly divided into the experimental group (32 cases) and the control group (28 cases). The experimental group was treated with negative pressure closed drainage combined with alginate adjuvant. The control group was treated with negative pressure closed drainage combined with sponge material. The number of dressing changes, wound healing time, wound pain level, wound granulation growth time and bacterial positive rate were compared between the two groups. Results The number of dressing changes in the experimental group was less than that in the control group, the degree of wound pain and bacterial positive rate of 7th and 14th day after treatment in the experimental group were lower than those in the control group, and the healing time and fresh granulation growth time of the wound in the experimental group were shorter than those in the control group (P＜0.05). Conclusion Negative pressure closed drainage combined with alginate adjuvant can effectively reduce the pain degree of patients with refractory burn wounds, the number of dressing changes, the growth of fresh granulation and wound healing time, and the incidence of wound infection. 2019 Vol. 26 (9): 82-84 [Abstract] ( 73 ) HTML (34 KB)  PDF  (0 KB)  ( 13 ) 85 Clinical effect of Acetylcysteine combined with Prednisone in the treatment of idiopathic pulmonary interstitial fibrosis CHEN Shi-mou ；GUO Yong-ming Objective To analyze the clinical effect of Acetylcysteine combined with Prednisone in the treatment of idiopathic pulmonary fibrosis. Methods A total of 102 patients with idiopathic pulmonary interstitial fibrosis admitted to our hospital from June 2017 to July 2018 were selected and divided into the control group and the observation group,with 51 cases in each group. In the control group, Prednisone was used, while in the observation group, Prednisone combined with Acetylcysteine was adopted. The indicators of lung function, clinical efficacy and incidence of adverse reactions were compared in the two groups. Results After treatment, the three lung function indicators including vital capacity (VC), total lung capacity (TLC) and FEV1/FVC, and the total therapeutic effectiveness rate in the observation group were higher than those in the control group, the total incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05). Conclusion Acetylcysteine combined with Prednisone in the treatment of idiopathic pulmonary interstitial fibrosis can effectively improve the clinical therapeutic effect. 2019 Vol. 26 (9): 85-87 [Abstract] ( 106 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 88 Clinical effect of bronchoalveolar lavage under fiberoptic bronchoscope in the treatment of severe pulmonary infection G AO Qing-lin； FU Yu Objective To investigate the efficacy of bronchoalveolar lavage under fiberoptic bronchoscope in the treatment of severe pulmonary infection. Methods A total of 126 patients with severe pulmonary infection treated in our hospital from May 2016 to November 2018 were selected and divided into the control group and the experimental group according to random number table method, 63 cases in each group. Patients in the control group were given routine treatment, while patients in the experimental group were given bronchoalveolar lavage under fiberoptic bronchoscope.The therapeutic effect, disappearance time of clinical symptoms and respiratory mechanics parameters of the two groups were observed and compared. Results The total effective rate of the experimental group was 95.24%, which was significantly higher than that of the control group (80.96%), with significant difference (P＜0.05). The time of lung rale disappearance, sputum disappearance and cough disappearance in the experimental group were shorter than those in the control group, with significant difference (P＜0.05). The lung compliance, thoracic compliance and total dynamic compliance of the experimental group after treatment were significantly higher than those of the control group, with significant difference (P＜0.05). Conclusion Bronchoalveolar lavage under fiberoptic bronchoscope can improve the therapeutic effect, clinical symptoms and respiratory mechanics parameters, and promote the rehabilitation of patients with severe pulmonary infection. It is worth popularizing and applying. 2019 Vol. 26 (9): 88-90 [Abstract] ( 65 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 91 Clinical application effect of general anesthesia with laryngeal mask and bronchial occluder in thoracoscopic single lung ventilation WANG Wei1；ZHANG Cheng-zuo；GAO Hang；LI Xue Objective To investigate clinical application effect of general anesthesia with laryngeal mask and bronchial occluder in thoracoscopic single lung ventilation. Methods A total of 94 patients with thoracoscopic single lung ventilation treated in our hospital from October 2014 to October 2017 were selected as the subjects, and divided into two groups by random number table method, with 47 cases in each group. The control group treated general anesthesia with tracheal catheter and bronchial occluder. The observation group treated general anesthesia with laryngeal mask and bronchial occluder. The changes of hemodynamic parameters were recorded in two groups. Pulmonary collapse scores were evaluated, and the recovery, peak airway pressure, adverse events were compared between two groups. Results The heart rate in observation group was lower than that in the control group at T2, T3, T4 (P＜0.05). Mean arterial pressure in observation group was lower than that in the control group at T2, T3, T4 (P＜0.05). The extubation time, spontaneous breathing time, eye opening time in observation group were earlier than those in the control group (P＜0.05). The pulmonary collapse score in observation group was higher than that in the control group (P＜0.05). There were no significant differences in peak airway pressure between two groups at different time points (before single lung ventilation,during single lung ventilation, after single lung ventilation) (P＞0.05). The incidences of adverse events (hoarseness,throat pain, cough, dysphagia) in observation group were lower than those in the control group (P＜0.05). Conclusion General anesthesia with laryngeal mask and bronchial occluder can be used in thoracoscopic single lung ventilation,which has good airway tightness and can improve ventilation effect of patients. It is worthy of clinical application. 2019 Vol. 26 (9): 91-94 [Abstract] ( 75 ) HTML (39 KB)  PDF  (0 KB)  ( 12 ) 95 Application effect of general anesthesia combined with ultrasound-guided paravertebral nerve block on rapid recovery of thoracic-laparoscopic radical esophagectomy LIN Xu-lin ；ZHANG Long-sheng ；ZHANG Huan-kai Objective To investigate the application effect of general anesthesia combined with ultrasound-guided paravertebral nerve block (USG-PVB) on rapid recovery of thoracic-laparoscopic radical esophagectomy (TLE). Methods Fifty patients who underwent TLE in our hospital from March to September 2018 were selected as the subjects, and randomly divided into observation group and control group, with 25 cases in each group. The USG-PVB was applied to the observation group under the induction of general anesthesia,and the control group only carrier out the induction of general anesthesia. The amount of vasoactive drugs and narcotic drugs in patients during surgery was observed and recorded. Cognitive function evaluation was performed using the simple intelligence state scale (MMSE) before and 2, 4,and 7 days after surgery. The pain visual analogue scale (VAS) score was observed at 1, 12, and 24 hours after surgery.Results The doses of sufentanil, remifentanil and propofol in the observation group were lower than those in the control group, the amount of phenylephrine was significantly higher than that of the control group (P＜0.05). There were no significant differences in MMSE scores between the two groups before and 7 days after surgery (P＞0.05). The MMSE scores of the observation group at 2 and 4 d after operation were significantly higher than those of the control group (P＜0.05). The VAS score of the observation group at 1, 12, 24 h after operation were significantly lower than thoes of the control group (P＜0.05). Conclusion General anesthesia combined with USG-PVB nerve block can reduce the amount of intraoperative anesthesia and vasoactive drugs, improve early cognitive dysfunction, and improve the quality of life of patients quickly. It is worthy of clinical application. 2019 Vol. 26 (9): 95-97 [Abstract] ( 55 ) HTML (32 KB)  PDF  (0 KB)  ( 14 ) 98 Effects of Propofol combined with Sevofluraneanesthesia on headache,dizziness, nausea and vomiting after thyroid surgery DING Jie-fu Objective To investigate the effects of Propofol combined with Remifentanil anesthesia on dizziness,headache, nausea and vomiting after thyroid surgery. Methods A total of 60 patients with thyroid surgery admitted to our hospital from January 2016 to January 2017 were selected as the subjects, and divided into observation group (30 cases) and control group (30 cases) on the principle of computer randomization. Propofol combined with Remifentanil induced in the observation group. In the control group, Sevoflurane anesthesia was used. The incidence of headache,dizziness, nausea and vomiting at different time points were compared between the two groups. Results The incidence of dizziness, headache, nausea and vomiting were lower than those of control group after operation of 4 h and 8 h (P＜0.05). There was no significant difference in the incidence of dizziness, headache and nausea and vomiting between the two groups 12 h after operation (P＜0.05). Conclusion The use of Propofol combined with Remifentanil in thyroid surgery can effectively control the occurrence of dizziness, headache, nausea and vomiting after operation. 2019 Vol. 26 (9): 98-100转104 [Abstract] ( 83 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 101 Effect of Sevoflurane Inhalation combined with Anesthesia on inflammatory response and anesthetic effect in patients undergoing laparoscopic radical operation for cervical cancer SUN Yang Objective To investigate the effect of Sevoflurane Inhalation combined with Anesthesia on patients undergoing laparoscopic radical operation for cervical cancer. Methods The clinical data of 92 patients undergoing laparoscopic radical operation for cervical cancer in our hospital from February 2016 to March 2018 were retrospectively analyzed. They were divided into the observation group (Sevoflurane Inhalation combined with Anesthesia) and control group (Propofol intravenous anesthesia), with 46 cases in each group. The effects of anesthesia, Interleukin-1 beta (IL-1β), Tumor necrosis factor-alpha (TNF-α) and heart rate (HR) were compared. Results There was no significant difference in anesthesia time between the two groups (P＞0.05). The time opening eyes, the time of recovery of spontaneous breathing, the time of recovery of orientation, and the time of speech response in the observation group were shorter than those in the control group (P＜0.05). The level of IL-1β and TNF-α in the observation group 10 minutes after pneumoperitoneum and 10 minutes after operation were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in HR between the two groups before anesthesia(P＞0.05). The HR in the observation group 10 minutes after pneumoperitoneum and 10 minutes after operation were lower than those in the control group, and the differences were statistically significant (P＜0.05). The level of IL-1β and TNF-α in the two groups 10 minutes after pneumoperitoneum and 10 minutes after operation were higher than those before anesthesia, and the differences were statistically significant (P＜0.05). The HR in the control group 10 minutes after pneumoperitoneum and 10 minutes after operation were higher than that before anesthesia (P＜0.05). The HR in the observation group 10 minutes after pneumoperitoneum was higher than that before anesthesia (P＜0.05). There was no significant difference in HR of the observation group before anesthesia and 10 minutes after operation (P＞0.05).Conclusion The recovery time of spontaneous breathing and speech response of patients undergoing laparoscopic cervical cancer radical operation under sevoflurane inhalation combined anesthesia is short, and the effect on inflammatory response and HR value is relatively small. 2019 Vol. 26 (9): 101-104 [Abstract] ( 67 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 105 Application effect of Ketorolac Tromethamine combined with Dexmedetomidine in elderly patients undergoing percutaneous kyphoplasty ZHANG Gu-yue； LU Liang-yuan Objective To investigate the effect of Ketorolac Tromethamine combined with Dexmedetomidine in elderly patients undergoing percutaneous kyphoplasty. Methods A total of 50 cases elderly patients with percutaneous kyphoplasty from January 2016 to December 2017 treated in our hospital were selected as the subjects, and divided into observation group (24 cases) and control group (26 cases) by random number table method. Patients in the observation group were given Ketorolac Tromethamine 30 mg after entering the operating room and then continuous injection of Dexmedetomidine at a rate of 0.5 μg/(kg·h) till the end of the surgery, while patients in the control group were given Sufentanil 0.15 μg/kg and then continuous injection of the same volume of physiological saline. The scores of anesthesia and the Ramsay sedation scores in patients were performed, and the incidence rate of adverse reactions were observed. Results At T1、T2 and T3, values of the mean arterial pressure (MAP) and heart rate (HR) in the observation group were significantly lower than those in the control group, the differences were statistical significance (P＜0.05). The satisfaction rate of anesthesia and sedation effect in the observation group were higher than those in the control group,the differences were statistical significance (P＜0.05). The frequency of additional topical anesthetics intraoperation in the observation group was less than that in the control group, the difference was statistical significance (P＜0.05). The incidence of adverse reactions showed no statistically significant difference between the two groups (P＞0.05). Conclusion The analgesic and sedative effect of Ketorolac Tromethamine combined with Dexmedetomidine in elderly patients undergoing percutaneous kyphoplasty is definite, without obvious complication. 2019 Vol. 26 (9): 105-107转111 [Abstract] ( 74 ) HTML (38 KB)  PDF  (0 KB)  ( 13 ) 108 Comparison of application effect between compound anaesthesia and local anaesthesia in ankle surgery LI Da； LU Jian-xin； LI Hui Objective To compare the application effect between compound anaesthesia and local anaesthesia in ankle surgery. Methods A total of 230 cases of ankle surgery patients treated in our hospital from October 2016 to October 2018 were selected as the research objects. According to different anesthesia methods, they were divided into the composite group and the local anesthesia group, with 115 cases in each group. The composite group was given compound anesthesia, and the local anesthesia group was given local anesthesia. The anesthetic effect was compared between the two groups. Results The excellent and good rate of anesthesia in the composite group was higher than that in the local anesthesia group, and the difference was statistically significant (P＜0.05). The heart rate and SBP of patients in the composite group were lower than those in the local anesthesia group 5, 15 and 30 minutes after anesthesia, while DBP was higher than those in the local anesthesia group, the difference was statistically significant (P＜0.05). The incidences of urinary retention, pain at the puncture site, poor postoperative sleep, and bradycardia in the composite group were significantly lower than those in the local anesthesia group, while the incidence of nausea and vomiting was higher than that in the local anesthesia group, and the postoperative pain score was lower than that in the local anesthesia group,with statistically significant differences (P＜0.05). The duration of sensory nerve block and motor nerve work block in the composite group were longer than those in the local anesthesia group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences between the two groups in sensory nerve block, motor nerve block onset time, preanesthesia heart rate, systolic blood pressure and diastolic blood pressure (P＞0.05). Conclusion In the process of implementation of the foot and ankle surgery compound anesthesia can improve the patients'postoperative analgesia effect, effectively prolong the time of postoperative analgesia, to a certain extent to ensure the patients who stability of heart rate and systolic blood pressure and diastolic blood pressure, has more ideal anesthesia than local anesthesia effect, is worthy of clinical promotion and application. 2019 Vol. 26 (9): 108-111 [Abstract] ( 68 ) HTML (39 KB)  PDF  (0 KB)  ( 10 ) 112 Clinical value of transperineal ultrasound measurement of cervical length,fetal fibronectin and serum nitric oxide in predicting preterm delivery LIN Qiao-yu； LUO Mei-hua Objective To investigate the value of transperineal ultrasound measurement of cervical length, fetal fibronectin and serum NO in predicting preterm delivery. Methods From January 2016 to December 2017, 50 pregnant women with threatened preterm birth (observation group) and 50 healthy pregnant women (control group) were enrolled in the People′s Hospital of Chenghai District in Shantou City of Guangdong Province, respectively. Fetal fibronectin combined with serum NO was detected and its predictive value was analyzed. Results The length of the cervix in the observation group was significantly shorter than that in the control group. The levels of fetal fibronectin and serum NO were significantly higher than those in the control group (P＜0.05). Correlation analysis showed that there was a significant negative correlation between cervical length and fetal fibronectin (r=-0.542, P=0.011), and cervical length was significantly negatively correlated with serum NO (r=-0.403, P=0.028), fetal fiber. Connexin was significantly positively correlated with serum NO (r=0.349, P=0.028). The optimal threshold for cervical length alone detection was 29.75 mm,area under the curve (AUC)=0.859, P=0.010, 95% confidence interval was (0.787, 0.931), sensitivity was 75.27%,specificity was 73.83%； optimal threshold for fetal fibronectin alone detection 78.21ng/ml, AUC=0.762, P=0.013, 95%confidence interval was (0.661, 0.863), sensitivity was 69.08%, specificity was 71.17%； optimal threshold for serum NO detection alone was 25.75 μmol/L, AUC=0.882, P=0.006, 95% confidence interval was (0.814,0.949), sensitivity was 73.81%, specificity was 77.08%. The AUC joint detection was 0.930, P=0.013, 95% confidence interval was (0.876, 0.984), sensitivity was 83.27 %, specificity was 81.35%. Conclusion The length of cervix in premature pregnant women is significantly shorter than that in healthy women. The levels of fetal fibronectin and serum NO are significantly higher than those of healthy women. The measurement of cervical length, fetal fibronectin and serum NO by perineal ultrasound is more predictive of preterm birth than the separate test. . 2019 Vol. 26 (9): 112-116 [Abstract] ( 57 ) HTML (40 KB)  PDF  (0 KB)  ( 11 ) 117 Application value of color Doppler ultrasonography of cervical vessels in elderly patients with ischemic stroke LI Xue-ying； SUN Cheng-hui； LI Jian； WU Yang-yan ；SUN Liu-mei Objective To explore the value of color Doppler ultrasonography of cervical vessels in elderly patients with ischemic stroke. Methods A total of 100 cases of elderly patients with ischemic stroke admitted to our hospital from December 2017 to September 2018 were enrolled in this study. At the same time, 100 healthy subjects who underwent physical examination in the same period were selected as the control group. Cervical vascular color Doppler ultrasonography was performed in both groups, and the results of the two groups were compared to evaluate the application value of color Doppler ultrasound in ischemic stroke. Results The intima-media thickness (IMT) of the bifurcations of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA) in the study group were higher than those of the control group, the detection rates of intimal thickening and plaque in the study group were higher than those of the control group, the total cervical artery stenosis in the study group was higher than that of the control group, the rate of mild stenosis was lower than that of control group, the rate of moderate and severe stenosis were higher than that of control group (P＜0.05). Conclusion In elderly patients with ischemic stroke, color Doppler ultrasonography of the neck vessels can effectively observe the atherosclerosis of the neck, provide an important basis for clinical diagnosis and treatment, and has many advantages such as convenient and economical, which can be widely promoted in primary care. 2019 Vol. 26 (9): 117-119 [Abstract] ( 75 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 120 Diagnostic value of ultrasound elastography in benign and malignant thyroid nodules WANG Yong-jian； LIU Bi-jun； DAI Chu-hong； HUANG Xue-ping Objective To evaluate the diagnostic value of ultrasound elastography in benign and malignant thyroid nodules. Methods A total of 40 patients with benign and malignant thyroid nodules (80 nodules, including 25 malignant nodules and 55 benign nodules) who needed surgical treatment in our hospital from October 2017 to September 2018 were randomly divided into control group and observation group according to the method of random grouping. The patients in the control group were diagnosed by conventional contrast-enhanced ultrasound, while the patients in the observation group were diagnosed by ultrasound elastography. The sensitivity, specificity, negative predictive value and accuracy of the two groups were compared. Results After both groups of patients were examined, the sensitivity, specificity, detection rate, positive predictive value and negative predictive value of the observation group were higher than those of the control group, and the differences between the two groups were statistically significant (P＜0.05). Conclusion The application of ultrasound elastography in the diagnosis of benign and malignant thyroid nodules can improve the accuracy of the examination, thus providing a reliable reference for clinical promotion. 2019 Vol. 26 (9): 120-122转126 [Abstract] ( 64 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 123 Clinical value of investigating the combined application of transabdominal and transperineal color Doppler ultrasonography in the diagnosis of placental location LUO Dong-gai； YIN Li-jun； HU Fang-ming； ZHONG Bai-quan； QIU Jie ；LEI Li-xiang Objective To explore the clinical value of investigating the combined application of transabdominal and transperineal color Doppler ultrasonography in the diagnosis of placental location. Methods A total of 55 pregnant women who came to our hospital for prenatal placental location determination and diagnosed with placental previa from October 2017 to October 2018 were selected and retrospectively analyzed. A total of 27 cases of parturient women who underwent simple transabdominal color Doppler ultrasonography were used as the simple group, and 28 cases of parturient women who underwent combined transabdominal and transperineal color Doppler ultrasonography. The diagnostic accuracy of the two groups was compared according to the clinicopathological diagnosis results. Results Among the 27 cases in the single group, 20 cases were diagnosed as placental previa, 6 cases missed diagnosis and 1 case misdiagnosed, the accuracy rate of the single group was 74.1%. While among 28 cases in the combined group, 27 cases were diagnosed as placental previa, 1 case was missed diagnosis, 0 case was misdiagnosed, the accuracy rate of the combined group was 96.4%. The diagnostic accuracy rate of combined group was higher than that of single group, the difference between the two groups was statistically significant (P＜0.05). Conclusion Combining the use of transabdominal and transperineal color Doppler ultrasonography can improve diagnostic accuracy in the diagnosis of placenta position which is low-cost, safe, simple and highly repeatable which has clinical value and worth popularizing. 2019 Vol. 26 (9): 123-126 [Abstract] ( 63 ) HTML (34 KB)  PDF  (0 KB)  ( 15 ) 127 Effect of Trimetazidine combined with high dose Atorvastatin Calcium in the treatment of unstable angina pectoris WANG Guo-hua； LI Qiu-feng ；CAI Hui-na； YAN Feng-ying Objective To explore the effect of Trimetazidine combined with high dose Atorvastatin Calcium in the treatment of unstable angina pectoris. Methods A total of 100 patients with unstable angina pectoris admitted to our hospital from August 2016 to January 2018 were randomly divided into observation group (50 cases) and control group(50 cases), the control group was treated with Trimetazidine combined with low dose Atorvastatin Calcium, while the observation group was treated with Trimetazidine combined with high dose Atorvastatin Calcium. The therapeutic effect,clinical indicators and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 96.00%, which was significantly higher than 80.00% of the control group, the difference was significant (P＜0.05). After treatment, the levels of hs-CPR, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) in the observation group were significantly lower than those in the control group, and high density lipoprotein cholesterol (HDL-C) was higher than that in the control group, the differences were significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Trimetazidine combined with high-dose Atorvastatin Calcium in the treatment of unstable angina pectoris is ideal, can improve the treatment effect, improve the level of related indicators, ensure the health of patients, has very important clinical significance. 2019 Vol. 26 (9): 127-129转132 [Abstract] ( 76 ) HTML (34 KB)  PDF  (0 KB)  ( 12 ) 130 Effect and safety of Rosuvastatin in the treatment of hyperlipidemia YANG Jing ；LAI Xiao-hua ；LIAO Shang Objective To explore the effect and safety of Rosuvastatin in the treatment of hyperlipidemia. Methods Forty-six patients with hyperlipidemia admitted to our hospital from December 2016 to December 2017 were selected as the study subjects, they were divided into group A (n=23) and group B (n=23) according to random number table method. Group A was given symptomatic treatment + Simvastatin, group B was given symptomatic treatment + Rosuvastatin, the total effective rate, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) levels and adverse reactions before and after treatment were compared between the two groups. Results The total effective rate of group B (95.65%) was significantly higher than that of group A(65.22%), the difference was significant (P＜0.05). The levels of TC, TG and LDL-C in the two groups after treatment were lower than those before treatment, the levels of HDL-C were higher than those before treatment, the levels of TC,TG and LDL-C in group B were lower than those in group A, the levels of HDL-C were higher than those in group A,the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in group B (13.04%) was significantly lower than that in group A (47.83%), the difference was statistically significant (P＜0.05). Conclusion Rosuvastatin has a good therapeutic effect on hyperlipidemia patients, can significantly improve the blood lipid metabolism, reduce cholesterol and low density lipoprotein cholesterol levels, drug safety is high. 2019 Vol. 26 (9): 130-132 [Abstract] ( 70 ) HTML (32 KB)  PDF  (0 KB)  ( 14 ) 133 Effect of Buzhong Yiqi Decoction in the treatment of cerebral atherosclerosis PENG Xu-jin Objective To investigate the effect of Buzhong Yiqi Decoction in the treatment of cerebral atherosclerosis.Methods Eighty patients with cerebral atherosclerosis admitted to our hospital from June 2015 to June 2017 were enrolled in the study. They were divided into the control group and the observation group according to different treatments, with 40 cases in each group. In the control group, conventional therapy was used, while in the observation group, Buzhong Yiqi Decoction was added on the basis of the control group. The total effective rate of treatment, clinical symptom relief time and hemorheology indexes before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.0%, which was significantly lower than that in the control group accounting for 77.5%, and the difference was statistically significant (P＜0.05). The hemiplegia relief time and relief time of dizziness and tinnitus in the observation group were significantly shorter than those in the control group, and the differences were statistically significant (P ＜0.05). There were no significant differences in platelet adhesion rate, whole blood viscosity and plasma viscosity between the two groups before treatment (P＞0.05).The platelet adhesion rate, whole blood viscosity and plasma viscosity of the two groups after treatment were significantly lower than those before treatment, and the differences were statistically significant (P＜0.05). The platelet adhesion rate, whole blood viscosity and plasma viscosity in the observation group after treatment were significantly lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The administration of Buzhong Yiqi Decoction in the treatment of patients with cerebral atherosclerosis can not only enhance the therapeutic effect, shorten the relief time of clinical symptoms, but also improve the hemorheology indexes, which is worthy of promotion and application. 2019 Vol. 26 (9): 133-135 [Abstract] ( 65 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 136 Effect of massage manipulation combined with moxibustion in the treatment of lumbar disc herniation and its influence on waist and leg function of patients XIE Li-na ；LI Kun ；SU Ze-sheng Objective To investigate the effect of massage manipulation combined with moxibustion in the treatment of lumbar disc herniation and its influence on waist and leg function of patients. Methods Sixty patients with lumbar disc herniation admitted to our hospital from March 2017 to November 2018 were selected as subjects. They were divided into group A and group B according to the random number table method, 30 cases in each group. Patients in the group A were treated with massage manipulation, and patients in the group B were treated with massage manipulation and moxibustion. The therapeutic effect, the visual analogue scale (VAS) score before and after treatment, and the positive rate of straight leg elevation test were compared between the two groups. Results The total effective rate of clinical treatment in the group B was 96.67%, which was higher than 70.00% in the group A, and the difference was statistically significant (P＜0.05). There was no significant difference in VAS score between the two groups before treatment (P＞0.05). The VAS scores of the two groups at 1 and 2 weeks after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The VAS scores of the group B at 1 and 2 weeks after treatment were lower than those of the group A, and the differences were statistically significant (P＜0.05). The positive rate of straight leg elevation test after treatment in the group B was 10.00%, which was significantly lower than that in the group A (36.67%), and the difference was statistically significant (P＜0.05). Conclusion The massage manipulation combined with moxibustion can significantly improve the therapeutic effect of lumbar disc herniation, reduce the degree of pain, and improve waist and leg function. 2019 Vol. 26 (9): 136-138 [Abstract] ( 82 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 139 Application effect of Liangyan moxibustion in the prevention and treatment of myopia REN Xiu-yun； YU Long Objective To explore the application effect of Liangyan moxibustion in the prevention and treatment of myopia. Methods A total of 60 patients (120 eyes) with myopia who were treated in Luanzhou City People′s Hospital from April to October in 2018 were selected as the subjects of study. They were divided into the observation group and the control group according to random number table method, 30 cases (60 eyes) in each group. The control group was treated with acupuncture combined with rotary exercise, while the observation group was treated with Liangyan moxibustion on the basis of the control group. The visual acuity and diopter before and after treatment, the therapeutic effect and the total incidence rate of adverse reactions were compared between the two groups. Results There were no significant differences in visual acuity and diopter between the two groups before treatment (P＞0.05). The visual acuity and diopter of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The visual acuity and diopter of the observation group after treatment were lower than those of the control group, and the differences were statistically significant (P＜0.05). The total effective rate of the treatment in the observation group was 96.67%, which was higher than that of the control group (86.67%), and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence rate of adverse reactions between the two groups (P＞0.05). Conclusion The application effect of Liangyan moxibustion in the prevention and treatment of myopia is significant, which can improve the visual acuity and the treatment effect, with less adverse reactions, which is worthy of promotion and application. 2019 Vol. 26 (9): 139-141转145 [Abstract] ( 125 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 142 Effect of Tianma Gouteng Decoction in the treatment of hypertension patients with the pattern of yin deficiency and yang hyperactivity YANG Yu-hong； SONG Ya-ling Objective To study the effect of Tianma Gouteng Decoction in the treatment of hypertension patients with the pattern of yin deficiency and yang hyperactivity. Methods A total of 64 cases of hypertensive patients with the pattern of yin deficiency and yang hyperactivity admitted to Wuhan General Hospital of WISCO from October 5, 2017 to June 21, 2018 were selected as the research subjects, and they were divided into the control group and the observation group by dynamic random grouping method, with 32 cases in each group. Patients in the control group were treated with conventional method, and patients in the observation group were treated with Tianma Gouteng Decoction. Blood pressure and biochemical indicators (aldosterone, angiotensin II, renin) before and after treatment and adverse reactions in the two groups were compared. Results There was no significant difference in blood pressure between the two groups before treatment (P＞0.05). The diastolic blood pressure and systolic blood pressure of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The diastolic blood pressure and systolic blood pressure after treatment of the observation group were (78.72±2.28) and (119.43±3.38) mmHg respectively, which were lower than those of the control group ([90.13±5.05], [135.37±2.26]) mmHg, and the differences were statistically significant (P＜0.05). There were no significant differences in biochemical indicators between the two groups before treatment (P＞0.05). The levels of aldosterone, angiotensin II and renin in the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The levels of aldosterone, angiotensin II and renin after treatment in the observation group were (280.11±3.74) ng/L, (108.14±5.25) ng/L,and (1.58±0.39) ng/ml respectively, which were lower than those in the control group ([309.87±4.04] ng/L, [119.70±4.38] ng/L, [4.11±0.55] ng/ml), and the differences were statistically significant (P＜0.05). The total incidence rate of adverse reactions was 3.13% in the observation group, which was significantly lower than the 21.88% in the control group, and the difference was statistically significant (P＜0.05). Conclusion The effect of Tianma Gouteng Decoction is remarkable in the treatment of hypertension patients with the pattern of yin deficiency and yang hyperactivity, which can effectively control the development of the disease. 2019 Vol. 26 (9): 142-145 [Abstract] ( 64 ) HTML (33 KB)  PDF  (0 KB)  ( 15 ) 146 Report of "critical value" in laboratory department and observation on the therapeutic effect of clinical critical care LIANG Jian-fu； ZHANG Chang-sen； FENG Ji-shun； DIAO Yu-lan Objective To explore the application effect of "critical value" report in deprtment of clinical laboratory in the treatment of clinical acute and critical diseases. Methods From May 1, 2015 to April 30, 2018, 2400 patients with clinical emergency and critical value were selected as study objects and they were divided into control group (1200 cases) and observation group (1200 cases) according to the visiting time. The patients in the control group were admitted when the "critical value" report in deprtment of clinical laboratory was not carried out from May 1, 2015 to October 31, 2016. While the patients in the observation group were admitted when the "critical value" report in deprtment of clinical laboratory in our hospital was carried out from November 1, 2016 to April 30, 2018. The awareness rate of "critical value" and the mastery rate of reporting process were compared in laboratory staff between the two groups. The clinical receiving time, disposal time, improvement time of critical value, return rate of "critical value", success rate of rescue and satisfaction degree of clinical departments were compared in patietns between the two groups. Results The awareness rate of "critical value" (100.0%) and the mastery rate of reporting process (100.0%) in the observation group were higher than those in the control group (60.0% and 40.0%), and the differences were statistically significant (P＜0.05). The clinical receiving time, disposal time and improvement time of critical value in the observation group were shorter than those in the control group, and the return rate of critical value (100.0%), success rate of rescue (92.3%)and satisfaction degree of clinical department (98.8%) in the observation group were higher than those in the control group (88.1%, 81.0%, 78.8%), and the differences were statistically significant (P＜0.05). Conclusion The "critical value" reporting system can significantly improve the professional skills and professional literacy of laboratory staff, and improve the rescue efficiency and success rate of clinical critical patients. It has a higher degree of satisfaction in clinical departments and deserves to be popularized and applied. 2019 Vol. 26 (9): 146-148 [Abstract] ( 66 ) HTML (32 KB)  PDF  (0 KB)  ( 14 ) 149 Application value of procalcitonin and high sensitivity C-reactive protein in differential diagnosis of pulmonary infection disease LIU Xiao-hua ；REN Ming-ming ；CHEN Tao ；CHEN Yu-ning Objective To explore the clinical value of procalcitonin (PCT) and high sensitivity C-reactive protein (hs-CRP) in the differential diagnosis of pulmonary infection, and to guide clinical rational use of antibiotics. Methods All of 112 cases of pulmonary infection (59 cases of Gram-negative bacteria, 21 cases of Gram-positive bacteria and 32 cases of fungi) in our hospital from July 2015 to June 2017 were selected as observation group. 48 healthy persons in the same period were selected as control group. Serum PCT and hs-CRP levels in each group were detected. Results The PCT level of Gram-negative bacteria group was significantly higher than that of Gram-positive bacteria group, fungal group and control group, and the differences were statistically significant (P＜0.05). The PCT level of Gram-positive bacteria group was significantly higher than those of fungal group and control group, and the differences were statistically significant (P＜0.05). The PCT level of fungal group was significantly higher than that of control group, and the difference was statistically significant (P＜0.05). The serum hs-CRP level of Gram-negative bacteria group, Gram-positive bacteria group and fungal group were significantly higher than that of control group, and the differences were statistically significant (P＜0.05), there was no statistical difference in the CRP level among the three groups (P＞0.05).Conclusion PCT level can distinguish Gram-negative bacteria, Gram-positive bacteria and fungal infections. PCT detection value can identify lung infection pathogens to a certain extent, and has certain clinical drug guiding effects. The hs-CRP test value can be used to reflect the degree of inflammation with pulmonary infection in patients. PCT and hs-CRP combined test can be used as an early differential diagnosis of pulmonary infection diseases, and have a good clinical application value. 2019 Vol. 26 (9): 149-151 [Abstract] ( 88 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 152 The value of blood routine, C-reactive protein and procalcitonin in the early diagnosis of infectious diseases in infants and young children SU Mei-jun ；KE Zhen-fu ；LIANG Mei-mei Objective To evaluate the clinical value of blood routine, C-reactive protein and procalcitonin in the early diagnosis of infectious diseases in infants and young children. Methods All of 100 infants and young children with infectious diseases admitted to our hospital from September 2017 to October 2018 were selected as observation group.According to the different infectious diseases, the illed children were divided into observation group 1 (bacterial infection) and observation group 2 (viral infection), 50 cases in each group. Fifty healthy infants and young children who underwent physical examination in our hospital at the same period were selected as the control group. Blood routine,C-reactive protein and procalcitonin were detected in all three groups. The blood routine white blood cell count, C-reactive protein and procalcitonin levels were compared among the three groups. Resluts The white blood cell count, Creactive protein and procalcitonin levels in observation group 1 and observation group 2 were significantly higher than those in the control group, and the differences were statistically significant (P＜0.05). The white blood cell count, C-reactive protein and procalcitonin levels in observation group 2 were significantly higher than those in observation group 1, and the differences were statistically significant (P＜0.05). Conclusion Blood routine, C-reactive protein and procalcitonin detection are applied to the early diagnosis of infectious diseases in infants and young children. The diagnosis of infectious diseases can be differentiated by white blood cell count, C-reactive protein and procalcitonin levels, providing the effective reference basis for early clinical diagnosis and treatment, clinical application value is higher. 2019 Vol. 26 (9): 152-154 [Abstract] ( 81 ) HTML (31 KB)  PDF  (0 KB)  ( 15 ) 155 Value analysis of five-joint inspection for vaginitis in leucorrhea routine inspection LUO Yuan-sheng ；PENG Xin-hua Objective To investigate the value of five-joint inspection for vaginitis in leucorrhea routine inspection.Methods From February 2015 to February 2018, 320 female patients admitted to our gynecological clinic were selected as study objects and they were divided into the microscopic examination method group and five-joint inspection method for vaginitis group according to the examination method, there were 160 cases in each group. The detection rate of vaginitis and vaginal cleanliness of the two groups were analyzed. Results The positive rate of vaginitis in the five-joint examination method for vaginitis group was 78.13%, which was significantly higher than that in the microscopic examination method group (63.35%), and the difference was statistically significant (P＜0.05). The detection rate of leucocytosis, Lactobacillus and Trichomonas vaginalis was 10.00%, 38.13% and 6.88% respectively in the five-joint inspection method for vaginitis group for vaginitis, and it was 8.75%, 35.63% and 10.00% in the microscopic examination method group respectively, and there were no significant differences between the two groups (P＞0.05). The detection rate of bacterial vaginitis (BV) and Candida was 12.50% and 10.63% respectively in the five-joint inspection method for vaginitis group, which was significantly higher than that in the microscopic examination method group (5.00%, 4.38%)respectively, and the difference was statistically significant (P＜0.05). There was no significant difference in the results of vaginal cleanliness between the two groups (P＞0.05). Conclusion The effect of the five-joint method for vaginitis detecting Candida and BV is better than routine examination. It is helpful for clinical diagnosis and has high accuracy.It is worth further discussion and promotion in clinic. 2019 Vol. 26 (9): 155-157 [Abstract] ( 101 ) HTML (32 KB)  PDF  (0 KB)  ( 14 ) 158 Analysis of Mycoplasma culture and drug sensitivity test results in 1780 urogenital tract specimens CHEN Xiao-kai；ZHONG Yue-chun Objective To analyze the infection of Ureaplasma urealyticum （UU）and Mycoplasma hominis（MH）and drug resistance of antibiotics in the First Peopole′s Hospital of Huizhou City. Methods All of 1780 urogenital tract specimens from the patients treated in the First Peopole′s Hospital of Huizhou City from January 2017 to July 2018 were collected. Mycoplasma infection and drug resistance were analyzed. Results In 1780 specimens, 1286 (72.25%)were Mycoplasma infection, 1053 cases (81.88%) were UU-positive, 30 cases (2.33%) were MH-positive, 203 cases(12.39%) were UU+MH-positive. The infection rate of Mycoplasma in women (77.53%) was significantly higher than that in men (11.27%) and the difference was statistically significant (P＜0.05). Drug susceptibility test showed that Mycoplasma was more susceptible to Doxycycline, Minocycline and Josamycin, while MH, UU+MH were more resistant to Clarithromycin, Roxithromycin, Azithromycin and Ofloxacin. Conclusion Mycoplasma infection in urogenital tract is major caused by UU, that mostly occurs in female. It is recommended to use high sensitive antibiotices such as Doxycycline, Minocycline, and Josamycin to treat. 2019 Vol. 26 (9): 158-160 [Abstract] ( 85 ) HTML (31 KB)  PDF  (0 KB)  ( 10 ) 161 Clinical application of three kinds of ABO blood type detection method PAN Guo-xiong； LIU Zhi-lin；HE Jia-ying； XIONG Liu-xin Objective To discuss the accuracy and influence factors of ABO blood type detected by microcolumn gel test (MGT), manual polybrene test (MPT) and slide method. Methods Blood identification samples of 3000 patients admitted to our hospital from December 2017 to June 2018 were analyzed, and ABO blood type was detected by MGT,MPT and slide method. Re-examination rate of blood group test results of three blood group detection methods was compared. The samples with suspicious blood group results were re-examined by adding reverse typing, and the factors affecting ABO blood type detection were analyzed. Results Among the 3000 samples, 57 cases were found to need to be re-examined for blood group results. According to the re-examination rate, MGT (0.17%)＜MPT (0.37%)＜slide method (1.37%). There was no significant difference in the rate of blood group re-examination between MGT and MPT(χ2=2.274, P=0.68551). There was a significant difference in the re-examination rate of blood group results between slide method and MPT method (χ2=18.378, P=0.00104), there was a significant difference in the re-examination rate of blood group results between MGT and slide method (χ2=29.556, P=0.00001). The influencing factors of blood type test results of three methods were as follows： slide method (70.7%)＞MPT (27.3%)＞MGT (20.0%)； equipment factor： MGT(80.0%)＞MPT (9.1%)＞Slide Method (7.3%)； operation factor： MPT (63.6%)＞Slide Method (22.0%)＞MGT (0.0%). Conclusion There are some deficiencies in three ABO blood group detection methods, the accuracy of MGT is higher than that of MPT and slide method. It is suggested that the combination of positive and negative typing be used to compensate for the deficiency of positive typing and provide accurate ABO blood type results for clinical transfusion treatment. 2019 Vol. 26 (9): 161-163转180 [Abstract] ( 73 ) HTML (35 KB)  PDF  (0 KB)  ( 11 ) 164 Role of refined management in improving the quality of operating room care and surgical efficiency SUN Li-li； JIN Lian-jin； ZHOU Xuan； LI Ying ；CUI Xiu-qin； HU Chun-yang Objective To explore the role of refined management in improving the quality of nursing care and the efficiency of surgery. Methods A total of 132 cases of surgical patients admitted to our hospital from February 2016 to September 2018 were selected as the study subjects. According to the method of random number distribution, they were divided into control group (66 cases) and observation group (66 cases). In the control group, the traditional operating room management mode was used, and in the observation group the refined management mode was adopted. The quality of care and the effect of surgery were compared between the two groups. Results The quality scores of health education,sterility, item management, knowledge assessment and nursing records in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The operation time, preoperative preparation time and operation time in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The implementation of refined management in the operating room can effectively improve the treatment efficiency of surgery and improve the quality of care, which is worth promoting. 2019 Vol. 26 (9): 164-166 [Abstract] ( 67 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 167 Application value of quality control circle in improving the attendance rate of circuit nurses in operating room MAI Cai-jiu ；CHAO Zi-lian； ZHU Wei-xia Objective To study the application value of quality control circle in improving the attendance rate of circuit nurses in operating room. Methods The clinical data of the operating room in our hospital from July 2015 to April 2016 were analyzed, through which the attendance rate of circuit nurses was obtained. After April 2016, the quality control circle activities were carried out and countermeasures were formulated for various reasons. The attendance rate of circuit nurses after the activities was calculated in December 2016. Results The number of absent nurses before activities was 1128 times/200, 555 times/200 after activities, and the standard rate was 105.33%. The number of absent nurses after activities was significantly lower than that before activities, and the difference was statistically significant(P＜0.05). Conclusion The use of quality control circle can effectively improve the attendance rate of circuit nurses in operating room, and has important significance for improving the quality of nurses as well as internal unity, which can be promoted and used in hospital operating room for nursing management. 2019 Vol. 26 (9): 167-169 [Abstract] ( 70 ) HTML (31 KB)  PDF  (0 KB)  ( 10 ) 170 Application effect of nursing mode of ward extended responsibility system in the rehabilitation of stroke patients GUO Ying； SHANG Yan-ping； JIA Jing Objective To investigate the application effect of nursing model of ward extended responsibility system in the rehabilitation of stroke patients. Methods A total of 250 hospitalized stroke patients from January to December 2017 were selected as the observation group, and another 230 hospitalized stroke patients from January to December 2016 were selected as the control group. Patients in the observation group were given the nursing model of ward extended responsibility system, while patients in the control group were given the routine rehabilitation nursing. The incidence of disuse syndrome during hospitalization, the degree of nursing satisfaction and the hospitalization time were compared between the two groups. Results The total incidence rate of disuse syndrome in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The total satisfaction of patients in the observation group was 98.40%, which was significantly higher than that in the control group (92.17%),and the difference was statistically significant (P＜0.05). The hospitalization time in the observation group was (67.60±1.08) d, which was shorter than that in the control group of (79.20±1.21) d, and the difference was statistically significant (P＜0.05). Conclusion The application of nursing model of ward extended responsibility system can significantly reduce the incidence of disuse syndrome in stroke patients, improve the degree of nursing satisfaction, and also shorten the hospitalization time, which is worthy of clinical promotion. 2019 Vol. 26 (9): 170-173 [Abstract] ( 56 ) HTML (34 KB)  PDF  (0 KB)  ( 14 ) 174 Analysis of influenza surveillance results in Liaoning Province from April 2017 to March 2018 WANG Lu-Lu ；SUN Hai-bo ；SUN Bai-hong； LIU Shuang ；SONG Yi-chun ；MAO Ling-ling ；SUN Ying-wei ；YAO Wen-qing Objective To analysis the epidemic trend of influenza in Liaoning Province from April 2017 to March 2018,to provide reference for influenza prevention and control. Methods The epidemiological data of influenza-like cases(ILI) and their pathogenic surveillance data and outbreak data of influenza-like cases from 21 influenza surveillance sentinel hospitals from 2017 to 2018 were analyzed. Results A total of 14 005 pharyngeal swabs were collected from 21 sentinel hospitals in Liaoning Province, the ILI reported by sentinel hospitals accounted for 3.65% of the total number of outpatient and emergency cases on average, the positive rate of nucleic acid test was 11.49%. The percentage of influenza-like cases (ILI%) had a significant peak in winter and spring. The age group under 15 years old was the main source of positive ILI and influenza nucleic acid, the proportion of positive ILI and positive nucleic acid detection was 74.27% (10 401/14 005) and 81.67% (1314/1609) respectively. From 2017 to 2018, A (H3N2), B (Yamagata) and A(H1N1) flu alternately prevailed in our province, while B (Victoria) was a low-level co-epidemic. Outbreak reports concentrated in primary and secondary schools accounted for 94.44% (17/18). Conclusion Influenza activity in Liaoning Province is high in winter and spring, influenza virus is mixed epidemic situation, and dominant strains alternate frequently. Children and the elderly need to focus on prevention and control, strengthen influenza vaccination, winter and spring schools are the focus of the outbreak. 2019 Vol. 26 (9): 174-177 [Abstract] ( 59 ) HTML (37 KB)  PDF  (0 KB)  ( 13 ) 178 Application effect of hand hygiene propaganda activities in medical staff CAI Chun-mei Objective To explore the influence of hand hygiene propaganda activities on the awareness rate, accuracy rate and compliance rate of hand hygiene in medical staff. Methods Fifty medical staff from June 2016 to June 2018 in our hospital were selected as the research objects to carry out hand hygiene propaganda activities. The correct rate,awareness rate, compliance rate and nosocomial infection rate of hand hygiene before and after the implementation of hand hygiene propaganda activities were compared. Results The correct rate, awareness rate and compliance rate of hand hygiene after the implementation of hand hygiene propaganda activities were significantly higher than before, and the nosocomial infection rate was significantly lower than before, the differences were statistically significant (P＜0.05).Conclusion Hand hygiene propaganda activities can effectively enhance the correct understanding of hand hygiene of medical staff, improve compliance, and reduce the incidence of nosocomial infections. The results are significant and worth learning. 2019 Vol. 26 (9): 178-180 [Abstract] ( 66 ) HTML (29 KB)  PDF  (0 KB)  ( 14 ) 181 Epidemiological and clinical characteristics of measles in Changzhou City from 2006 to 2015 SHENG Yuan-ji ；TONG Xue-cheng； XU Tian-min Objective To explore the epidemiological and clinical characteristics of measles in this area, and to provide evidence for the prevention and control of measles. Methods The clinical data of 631 patients with measles admitted to our department from 2006 to 2015 were retrospectively analyzed. Results After 2008, the epidemic intensity of measles in this area decreased, and the epidemic season mainly concentrated in winter and spring, the onset age of measles mainly concentrated in ＜8 months to 4 years old and 20 to 30 years old. Morbidity population and diaspora children are the main groups of the patients. 209 cases (33.1%) had a history of measles exposure before onset, and 85 cases(13.5%) had been vaccinated against measles. All patients had fever and rash, 536 patients (84.9%) had peak body temperature ＞39℃. Measles patients had different degrees of liver damage and myocardial damage, and the positive rate of measles virus antibody IgM was high. Antiviral therapy, symptomatic treatment and support were the main treatment. All patients were cured and discharged without death. Conclusion In recent years, there have been some new changes in the intensity, age distribution and clinical characteristics of measles in this region. Strengthening immunization, active isolation and treatment of patients are of great significance in controlling and eliminating measles. 2019 Vol. 26 (9): 181-183 [Abstract] ( 68 ) HTML (29 KB)  PDF  (0 KB)  ( 15 ) 184 Application exploration of strengthening the communication between doctors and patients in the clinical teaching of neurological diseases LAI Yu-jie ；CHENG Yuan-yuan；YOU Qiu-xiang In recent years, the contradiction between doctors and patients has gradually become a social problem. The contradiction between doctors and patients in China is becoming more and more severe. It is closely related to the distortion of social values and the imperfect medical system, and a large part is related to the lack of humanistic care and undesirable communication between doctors and patients. A favorable doctor-patient communication can not only improve the satisfaction and compliance of patients, but also can effectively avoid the occurrence of medical disputes. Improving the communication skills of clinicians with patients and their families is of great significance to building a harmonious medical relationship and reducing unnecessary medical disputes. The clinicians who are about to start their work have only learned the theoretical knowledge of doctor-patient communication during the theoretical course of the university, but lack basic communication ability and skills. This article combines the clinical practice of neurology department, from how to train a qualified physician with good doctor-patient communication ability, proposes a more rational medical teaching method, and hopes to explore a set of ways to improve the communication skills of clinicians and doctors in neurological diseases. The clinical teaching method integrates the communication between doctors and patients into regular teaching, and promotes the application to enable students to master the methods of communication between doctors and patients while mastering theoretical skills, to enhance practicality and provide guarantee for the smooth progress of clinical work. 2019 Vol. 26 (9): 184-186 [Abstract] ( 81 ) HTML (31 KB)  PDF  (0 KB)  ( 10 ) 187 Practical research on the cultivation of the professionalism for the students studying pharmacology in higher vocational school with experimental teaching as a carrier JI Yao-hua；LI Xin The current training of the students in high vocational schools has the current situation of too much focus on skills and less focus on quality education. In view of the employment characteristics and existing problems of current students studying pharmacology in high vocational schools, this paper deepens the connotation of experimental teaching by reforming the experimental contents, standardizing the management of experimental supplies, the management of experimental process responsibility and safety, and the standardization of practical skills, so as to infiltrate professionalism education and training into all aspects of experimental teaching, and build a teaching model for various training before conducting a comprehensive production project, including training of necessary knowledge for professional theory, training of basic skills in positions, and the knowledge education with the focus on quality and safety production according to the characteristics of the industry. The working environment of the workplace is also simulated,so that students have some understanding and awareness of the future workplace, in order to improve the professional quality of students and help students adapt to work as soon as possible. 2019 Vol. 26 (9): 187-189转204 [Abstract] ( 59 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 190 Application effect of offline and online mixed teaching mode based on classroom and MOOC in nursing teaching GAO Fan-shu；HU Ying；WANG Cheng-yuan； WANG Kun Objective To explore the application effect of offline and online mixed teaching mode based on classroom and MOOC in nursing teaching. Methods A total of 136 students of the 2017 grade nursing undergraduates in Mudanjiang Medical University from March to July 2018 were selected as the research subjects. They were divided into the control group and the observation group according to the random number table method, with 68 cases in each group.The students in the control group adopted the conventional teaching method, and the students in the observation group adopted the offline and online mixed teaching mode based on classroom and MOOC. After the end of the teaching, the students in the observation group were selected as the survey objects, and the teaching effect of the offline and online mixed teaching mode based on classroom and MOOC was investigated. All students were selected as survey subjects to compare the comprehensive abilities of the two groups. Results Most of students in the observation group were satisfied with the teaching effect of the offline and online mixed teaching mode based on classroom and MOOC, and the total satisfaction rate was above 90%. The scores of learning ability, time utilization ability, communication ability and knowledge induction ability in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The offline and online mixed teaching mode based on classroom and MOOC can effectively improve the teaching effect of nursing students. 2019 Vol. 26 (9): 190-192 [Abstract] ( 59 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 193 Clinical analysis and experience of acute exogenous lipid pneumonia in 5 children DAI Hong-fa； MI Pei-ming ；LIAO Cui-le； HUANG Zhi-rong； WEN Shang-mei Exogenous lipid pneumonia is a rare and severe pneumonia. It is of great significance for timely clinical treatment to detect and diagnose it in time. Through participating in the diagnosis and treatment of 5 children with acute exogenous lipid pneumonia, the clinical data, imaging characteristics, treatment and prognosis were discussed and analyzed. It was concluded that early chest X-ray or CT examination plays an important role in the timely detection and diagnosis of children′s acute exogenous lipid pneumonia. Bronchoalveolar lavage combined with local ICS and shortterm intravenous glucocorticoid therapy can significantly improve the clinical symptoms and improve the cure rate. 2019 Vol. 26 (9): 193-195 [Abstract] ( 71 ) HTML (30 KB)  PDF  (0 KB)  ( 12 ) 196 Treatment and nursing experience of a patient with paraneoplastic pemphigus LI Xin-nan ；ZHANG Yan-mei A male patient with paraneoplastic pemphigus and bullous pemphigoid in our hospital was provided with normal saline with gentamicin and dexamethasone for wet compressing in an external-application way combined with red blue light irradiation. After therapy, targeted nursing on wound, diet, and mind was applied. The disease conditions such as the patients′ vital signs and psychological state were observed, then effectively prevented the recurrence of disease after treatment and nursing, and then summarized the pathogenesis and cautions of treatment and nursing of paraneoplastic pemphigus, and possessed a more comprehensive understanding of the signs of this chronic, autoimmune bullous skin mucosal disease. It is clear that secondary infection was a leading cause for death. 2019 Vol. 26 (9): 196-198转210 [Abstract] ( 76 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 199 Clinical effect of thin combined with calcium alginate dressing in preventing early complications after PICC catheterization in elderly tumor patients HUANG Fen；ZHANG Jie-ling；FAN Bin；ZHANG Yu-hong Objective To evaluate the effect of thin combined with calcium alginate dressing in preventing the early complications related to PICC tube insertion in elderly tumor patients. Methods During the period between May 2016 and December 2017, three hundred and six elderly tumor patients were enrolled in the study. Patients were randomly divided into control group (n=150) and observation group (n=156) by the order of catheterization. Patients in the control group were treated with wet hot compress to prevent early complications after catheterization, while the patients in the observation group were treated with thin combined with calcium alginate dressing after catheterization. The incidence of the PICC catheter related complications were evaluated for asubsequent week. Results Dressing ooze blood soaked states on the puncture points, PICC catheter-induced phlebitis and venous thrombosis rate in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P＜0.05）. Conclusion The adoption of thin combined with calcium alginate dressing after PICC catheterization can effectively reduce the incidence of early complications related to PICC catheterization in elderly tumor patients， and relieve patients′ suffering as well as nurses′ workload. It′s worthy of clinical promotion. 2019 Vol. 26 (9): 199-201 [Abstract] ( 68 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 202 Influence of psychological intervention on rehabilitation of children with severe hand foot mouth disease and family members′ psychological state ZHU Jin；ZHANG Wei-li； XU Xuan； LI Man； ZHU Qing-xiong； HU Yuan Objective To explore the effect of psychological intervention on rehabilitation of children with severe hand foot mouth disease (HFMD) and their family members′ psychological state. Methods A total of 60 children with severe HFMD and their family members admitted to Jiangxi Children′s Hospital from June 2016 to December 2017 were selected and randomly divided into control group and research group, 30 cases in each group. The control group was given routine nursing on the basis of clinical treatment, while the research group was given psychological intervention on the basis of the control group. The hospitalization time, critical illness conversion rate and family anxiety self-rating scale (SAS) scores before and after intervention were compared between the two groups. Results The hospitalization time of the research group was significantly shorter than that of the control group (P＜0.05), the transformation rate of critical illness in the research group was significantly lower than that of the control group (P＜0.05), and the SAS score of the two groups after intervention was significantly lower than that before intervention (P＜0.05), and the research group was significantly lower than that of the control group, the differences were statistically significant (P＜0.05）.Conclusion Psychological intervention can shorten the hospitalization time of children with severe HFMD, reduce the conversion rate of critical illness, and alleviate the anxiety of family members of children with severe HFMD. 2019 Vol. 26 (9): 202-204 [Abstract] ( 74 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 205 Effect of self-management skill training combined with music therapy on self-care ability and rehabilitation of schizophrenic patients LU Shen-Yan ；QIN Jin-rong； WEI Sheng-zhong ；MO Li-li ；LIAO Hai-cen； YANG Dai-lan Objective To explore the effect of self-management skill training combined with music therapy on self-care ability and rehabilitation effect of patients with schizophrenia. Methods A total of 120 schizophrenic patients who hospitalized in our hospital from January to December 2017 were selected and divided into study group (n=60) and control group (n=60) according to random number table method. The control group received routine drug therapy and nursing care, on this basis, the study group was implemented an eight-week self-management skills training combined with music therapy. The self-care ability and rehabilitation function of the inpatients were evaluated by the nurse observation scale (NOSIE), and the activity of daily living (ADL). Results After 8 weeks of intervention, the scores of ADL in the study group were significantly lower than those in the control group, the total NOSIE score was significantly higher than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion The combination of self-management skill training and music therapy can improve the ability of self-care of mental patients, promote the recovery of disease and reduce the recurrence rate. 2019 Vol. 26 (9): 205-207 [Abstract] ( 76 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 208 Application effect of targeted nursing in patients undergoing general anesthesia in surgical operation DING Zhi-hong Objective To explore the effect of targeted nursing on restlessness, heart rate and blood pressure during anesthesia recovery period in patients undergoing general anesthesia. Methods A total of 96 patients who underwent surgery and general anesthesia in our hospital from January 2015 to October 2016 were selected as the research subjects. According to their nursing methods, they were divided into the control group and the observation group, 48 cases in each group. The control group was given routine nursing, while the observation group was given targeted nursing.The degree of restlessness, heart rate and blood pressure during anesthesia recovery between the two groups were compared. Results The total incidence of restlessness in the observation group was 29.17%, which was significantly lower than that in the control group (P＜0.05). The heart rate, diastolic blood pressure and systolic blood pressure in the observation group were significantly lower than those in the control group at the recovery stage, the differences were statistically significant (P＜0.05). Conclusion The application of targeted nursing in the recovery period of general anesthesia patients can effectively reduce the agitation level in the anesthesia period, which is beneficial to the stable heart rate and blood pressure, which is worthy of clinical application. 2019 Vol. 26 (9): 208-210 [Abstract] ( 82 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 211 Application effect of family companionship nursing in cesarean section WANG Fang ；SUN Xiao-feng Objective To explore the application effect of family companionship nursing in cesarean section. Methods A total of 232 maternal women admitted to our hospital from June 2016 to June 2018 were enrolled. According to whether there were family members accompanying during cesarean section, they were divided into control group (n=116) and observation group (n=116). In the control group, there was no family accompanying, but regular nursing intervention was implemented. In the observation group, family companionship nursing was adopted. The self-rating anxiety scale (SAS), the satisfaction on the medical staff in the operating room, and the incidence of adverse events in puerperal and neonate during perinatal period were compared. Results The postpartum SAS scores of the cesarean section women and their families were lower than those of the control group (P＜0.05). The total satisfaction on medical staff in the operating room staff was higher than that of the control group (P＜0.05). The total intraoperative discomfort rate and postpartum depression occurring in the observation group were lower compared with those in the control group (P＜0.05).The incidence of neonatal infection and total complications in the observation group was lower than that in the control group (P＜0.05). Conclusion The implementation of intraoperative family companionship care for women undergoing cesarean section can improve the anxiety of maternal and their families, reduce the incidence of postoperative discomfort and depression, and ensure maternal and child health. 2019 Vol. 26 (9): 211-213 [Abstract] ( 73 ) HTML (30 KB)  PDF  (0 KB)  ( 14 ) 214 Clinical study on the prevention and treatment of Honeysuckle in skin toxicity induced by Cetuximab DU Yong-li； LUO Dan-gu； TAN Zhi-bo； HE Jia-ling Objective To evaluate the effect of Honeysuckle in preventing and curing skin toxicity induced by Cetuximab. Methods From July 2016 to April 2018, 60 patients with colorectal cancer treated by Cetuximab Plus chemotherapy in Shenzhen Hospital of Southern Medical University and the Eighth Affiliated Hospital of Sun Yat-sen University were selected as subjects, and randomly divided into experimental group (30 cases) and control group (30 cases) in a 1∶1 ratio. The experimental group was given Honeysuckle 4 times per day during the whole process, while Honeysuckle was administered in the control group only after the occurrence of skin toxicity of grade Ⅲor above. Single-blind method was used to record the occurrence of skin toxicity in two groups.The number of cases in each grade of skin toxicity,the occurrence time, the alleviation proportion in two groups were compared. Results The severity of skin toxicity in the experimental group was lower than that in the control group,the difference was statistically significant (P＜0.05). After the first second degree of skin toxicity，the proportion of skin toxicity in the experimental group that did not continue to aggravate was higher that in the control group, the difference was statistically significant (P＜0.05). The occurrence time of grade Ⅱskin toxicity in the experimental group([23.8±3.8]days)was longer than that in the control group([15.1±3.2]days),and the differences were statistically significant (P＜0.05）. The proportion of patients suffering from grade Ⅱskin toxicity that has not deteriorated in the experimental group (68.2%) was higher than that in the control group (33.3%), and the differences were statistically significant (P＜0.05）.The alleviation proportion of grade Ⅲskin toxicity or above in expe rimental group and control group (71.4% and 72.7% respectively) was statistically insignificant (P＞0.05）.Conclusion Honeysuckle may have a good effect on prevention and treatment of skin toxicity induced by Cetuximab, but it needs further studies with large samples. 2019 Vol. 26 (9): 214-217转231 [Abstract] ( 68 ) HTML (40 KB)  PDF  (0 KB)  ( 8 ) 218 Application effect of behavioral stage transition theory in self -management of outpatients with type 2 diabetes mellitus LIU Jing； LI Li-chang； ZENG Kun； ZHANG Hai-hui Objective To analyze the application of the oretical model of behavior stage transition （TTM） with type 2 diabetes mellitus (T2DM). Methods A total of 120 T2DM patients who visited the diabetes specialist clinic of our hospital from June 2016 to June 2017 were selected as study objects. They were randomly divided, the experimental group and the control group. Each group had 60 cases. The control group was given the guidance of the routine health education model of diabetes, while the experimental group was given the individualized instruction of TTM. The fasting blood-glucose (FPG), 2-hour post-meal blood glucose (2 h PG), body weight and glycosylated hemoglobin （HbA1c）of two groups were compared at the different time. The health behavior self-efficacy scale of diabetes was used to evaluate the results. Results After 6 months′ education, FPG, 2 h PG, HbA1c and body weight in both groups were significantly lower than those before education (P＜0.05). FPG, 2 h PG, body weight and HbA1c of the experimental group at the 6, 9 and the 12th month were all significantly lower than those in the control group (P＜0.05). The self-efficacy scores of the experimental group after education were significantly higher than that of the control group, the differences were statistically significant (P＜0.05). Conclusion The individualized education guidance of TTM in patients with T2 DM,can control blood glucose significantly and improve self-health efficiency, which is worthy of clinical application. 2019 Vol. 26 (9): 218-220 [Abstract] ( 70 ) HTML (31 KB)  PDF  (0 KB)  ( 17 ) 221 Application effect of evidence-based nursing in neonatal asphyxia resuscitation LIU Yu-lian； LAI Hua-chun； WANG Xian-qing； CAO Feng-yun； LIU Xiao-jian Objective To explore the effect of evidence-based nursing on the nursing effect of asphyxia neonatal asphyxia resuscitation. Methods From January 2014 to December 2016, 198 neonates were randomly selected from our hospital for suffocation resuscitation. The stratified randomization method was used, from January 2014 to December 2015, the neonates with asphyxia were used as the control group (103 cases), the neonates with asphyxia from January to December 2016 were used as the experimental group (95 cases), the control group was treated with routine nursing, and the experimental group was given based on evidence care methods. The Apgar score, the improvement of arterial blood gas index and the evaluation results of nursing service were compared between the two groups. Results The 1 and 5 minutes Apgar scores of the children in the experimental group were higher than those in the control group. The difference was statistically significant (P＜0.05). The PaO2 of the two groups was higher after nursing than that before the nursing. The PaCO2 level was lower than that before the nursing, the difference was statistically significant (P＜0.05).After the nursing, the PaO2 level of the experimental group was higher than that of the control group, and the PaCO2 level was lower than the control group, the differences were statistically significant (P＜0.05). The total satisfaction rate of the experimental group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion Evidence-based nursing in obstetrics can provide timely and effective nursing interventions, which can improve the timeliness and effectiveness of neonatal asphyxia resuscitation. 2019 Vol. 26 (9): 221-223 [Abstract] ( 77 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 224 Effect of anxiety regulation training on negative emotion in patients with post-schizophrenia depression ZHANG Feng-ying； HE Fang-mei ；ZHANG Xiao-qing Objective To investigate the effect of anxiety regulation training on negative emotions in patients with postschizophrenia depression. Methods A randomized, open-label, prospective study was conducted in 60 patients with post-schizophrenia depression who were admitted to the Third People′s Hospital of Meizhou City from April 2014 to June 2017. According to the selection criteria for schizophrenia in the international classification of diseases (ICD-10),they were divided into the study group and the control group according to random number table method, 30 cases in each group. Regular treatment was adopted in two groups, while the control group was given routine nursing care, the study group was applied anxiety regulation training on the basis of routine nursing, and the negative emotions of the two groups before training and after 6 weeks of training were analyzed and compared using the self-rating anxiety scale(SAS) and the self-rating depression scale (SDS) were used to evaluate their anxiety and depression. Results Before the training, there were no significant differences in the scores of SAS and SDS between the two groups (P＞0.05). After 6 weeks of training, the SAS and SDS scores of the study group were significantly lower than that of the control group, the differences were statistically significant (P＜0.05). Conclusion Anxiety regulation training can effectively improve the negative emotions of patients with post-schizophrenia depression and provide a more effective method for rehabilitation nursing of patients with post-schizophrenia depression. 2019 Vol. 26 (9): 224-226转234 [Abstract] ( 76 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 227 Influence of Wechat interactive health education on related indicators of patients with type 2 diabetes mellitus with high-risk foot HUANG Yu-juan ；ZHU Pei-yu ；MU Zhen-zhen Objective To investigate the effect of Wechat interactive health education on the indexes of type 2 diabetes (T2DM) with high-risk foot patients. Methods A total of 100 cases of high-risk foot patients with T2DM hospitalized in our hospital from January 2017 to January 2018 were selected as objects of study. They were divided into control group and intervention group according to the random number table method, 50 cases in each group. The control group was given routine drug treatment and diabetes knowledge health education before discharge, and the intervention group was given interactive health education on the basis of Wechat on the basis of the control group. Specialist knowledge, self-efficacy, ankle brachial index (ABI), glycated hemoglobin (HbA1c), fasting blood glucose (FBG), postprandial 2 hour blood glucose (2 h PBG), total cholesterol (TC), three acyl glycerol (TG), low density lipoprotein cholesterol(LDL-C) and high-density fat eggs, changes in white cholesterol (HDL-C) and foot injuries were compared between the two groups of patients before and after discharge intervention. Results There were no significant differences between the two groups in diabetes knowledge, self-efficacy, ABI, blood sugar and blood lipid levels, and the skin condition of foot without Wechat intervention (P＞0.05）. There were significant differences between the two groups in diabetes specialist knowledge, self-efficacy, ABI, blood glucose, blood lipid level and foot skin condition with Wechat intervention(P＜0.05）. Self-efficacy, blood glucose, ABI, blood lipid levels and skin condition of foot in intervention group were higher than those in control group (P＜0.05）. Conclusion Wechat interactive health education can effectively improve the blood sugar level of patients with high risk foot of T2DM, improve the knowledge and self-efficacy of preventing diabetic foot, and reduce the occurence of complications. 2019 Vol. 26 (9): 227-231 [Abstract] ( 67 ) HTML (42 KB)  PDF  (0 KB)  ( 5 ) 232 Application effect of vascular access nursing on hemodialysis patients LI Ni-hong Objective To explore the effect of vascular access nursing in hemodialysis (HD) patients. Methods Altogetner 60 cases of HD patients admitted to our hospital from June 2016 to June 2018 were selected for the study. According to the random number table method, they were divided into observation group and control group. The patients in the control group received routine nursing measures, including informing the patients and their family members of the relevant matters needing attention in HD treatment, correcting the patients′ bad daily life style, arranging the patients′work, rest and diet reasonably etc. The patients in the observation group received nursing procedure of vascular access,including protection of vascular access,puncture nursing and nursing of internal fistula of vascular access.The total incidence of complications and nursing satisfaction were compared between the two groups. Results The total incidence of complications in the observation group was 6.66%, which was lower than that in the control group (23.33%) (P＜0.05）；the satisfaction rate in the observation group was 93.33%, which was higher than that in the control group (70.00%) (P＜0.05）. Conclusion For HD patients, the use of vascular access nursing can effectively reduce the incidence of complications, and is conducive to improving patient satisfaction with nursing, which is worthy of further clinical application. 2019 Vol. 26 (9): 232-234 [Abstract] ( 71 ) HTML (29 KB)  PDF  (0 KB)  ( 17 ) 235 Effect of psychological nursing and corresponding nursing measures on pregnant women with threatened premature delivery during the period of pregnancy preservation WEI Hai-rong objective To explore the psychological nursing and the corresponding nursing measures in pregnant women with threatened premature birth during the period of pregnancy preservation. Methods From March 2014 to March 2017, 100 cases of pregnant women admitted to our hospital with threatened preterm delivery were selected as the study subjects. All of them were divided into control group and observation group according to random number table method, 50 patients in each group. The control group patients were given conventional nursing, observation group patients were given conventional nursing plus the corresponding nursing measures. Anxiety and fear during pregnancy were compared between the two groups. Results The scores of anxiety and fear were significantly lower in the observation group than those in the control group (P＜0.05）. The overall effect of pregnancy extension in the observation group was significantly better than that in the control group, and the differences were statistically significant (P＜0.05）. Conclusion Through the study of the psychological characteristics of pregnant women during threatened preterm labor, the observation group of patients with the corresponding nursing measures can improve their mental health significantly,prolong the gestation, and it is the key to ensure the success of threatened preterm labor treatment. 2019 Vol. 26 (9): 235-237 [Abstract] ( 53 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 238 Analysis of the effect of personalized nursing in surgical nursing of acute appendicitis LUO Xiu-hua； FU Jian-mei； XIONG Qin-lin Objective To observe the effect of personalized nursing in the surgical nursing of acute appendicitis.Methods Sixty-nine patients with acute appendicitis admitted to our hospital from June 2017 to June 2018 were enrolled. The patients were divided into individualized nursing group (n=35) and routine nursing group (n=34) according to the single and double numbers of hospitalization numbers. The routine nursing group was given routine nursing, and the personalized nursing group was given personalized nursing. The recovery time of gastrointestinal function, hospitalization time, total nursing satisfaction and incidence of adverse reactions were compared between the two groups. Results The recovery time of gastrointestinal function and hospitalization time in the individualized nursing group were shorter than those in the routine nursing group, and the differences were statistically significant (P＜0.05）. The total satisfaction degree of personalized nursing group was higher than that in the routine nursing group, and the total incidence of adverse reactions was lower than that in the routine nursing group, the differences were statistically significant(P＜0.05). The effect of personalized nursing the surgical nursing of acute appendicitis is quite significant and worthy of clinical adoption. 2019 Vol. 26 (9): 238-240 [Abstract] ( 71 ) HTML (30 KB)  PDF  (0 KB)  ( 11 ) 241 Application effect of nursing intervention of four-hand operation in patients with CAD/CAM all-ceramic restoration by chair WU Shao-mei Objective To explore the effect of four-handed nursing intervention on the treatment time and satisfaction of patients with CAD/CAM all-ceramic restoration. Methods From June 2016 to June 2018, 154 cases of CAD/CAM all-ceramic repair patients in our hospital were selected. They were divided into two groups according to random number table method, 77 cases in each group. The control group was given the chairside CAD/CAM all-ceramic restoration care, while the study group was given four hands-on nursing intervention. The psychological status and treatment time of the two groups before and after intervention were observed, and the repair effect and satisfaction of the two groups were evaluated. Results The treatment time of the study group was shorter than that of the control group (P＜0.05). There were no significant differences in SDS and SAS scores between the two groups before intervention （P＞0.05）. The SDS and SAS scores of the two groups were lower than those before the intervention, and the study group was lower than the control group (P＜0.05). The repair rate and total satisfaction rate of the study group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Four-handed nursing intervention can effectively improve the psychological state of patients with CAD/CAM all-ceramic restoration, shorten the treatment time, enhance the repair effect, and improve patient satisfaction, which is worthy of popularization and application. 2019 Vol. 26 (9): 241-243 [Abstract] ( 58 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 244 Application of humanistic nursing in the hearing screening for infants GUO Xiao-qing； LIU Qing-ming； YU Juan-juan Objective To explore the application effect of humanized nursing in infant hearing screening. Methods A total of 114 infants and children who received hearing screening in our hospital from March 2017 to May 2018 were selected, and all infants were divided into observation group and control group according to the numerical randomization method, 57 cases in each group. The control group received routine nursing during the hearing screening, while the observation group received humanized nursing, and the hearing screening results and total nursing satisfaction of the two groups were compared. Results All 53 infants and children in the observation group passed the hearing screening,with a passing rate of 92.98%, and 45 infants and children in the control group passed the hearing screening, with a passing rate of 78.95%，the difference was statistically significant (P＜0.05). The total nursing satisfaction of the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05）. Conclusion Humanized nursing for infants and young children′s parents during infant hearing screening can significantly improve the passing rate of infant hearing screening, optimize the quality of hearing screening, and at the same time improve the nursing satisfaction of infants and young children′s parents, which is of good clinical value. 2019 Vol. 26 (9): 244-246 [Abstract] ( 67 ) HTML (30 KB)  PDF  (0 KB)  ( 13 ) 247 Application effect of continuous nursing in patients transferred from ICU WANG Rui-xuan； XU Zhi-ying ；LIN Ze-lan Objective To explore the effect of continuous nursing in patients transferred from ICU. Methods From June 2016 to June 2018, 120 patients transferred from ICU of our hospital were selected. The patients were divided into control group (from June 2016 to May 2017) and observation group (from June 2017 to June 2018), 60 cases in each group. The control group adopted normal nursing mode, the observation group adopted continuous nursing mode. The ICU reentry rate, the cause of returning, the physiological indexes and medical compliance behavior in the two groups were compared. Results The ICU reentry rate in the observation group was 3.33%, it was significantly lower than that in the control group (20.00%) (χ2=8.086, P=0.004). Among the reasons for the returning, the respiratory disease was the primary cause, followed by heart failure and intracranial rebleeding or obstruction, and finally the cardiac arrest and surgical complications， the mean arterial pressure (MAP), heart rate(HR), breathing rate (RR), partial pressure of carbon dioxide (PaCO2) and usea nitrogen (BUN) in observation group were significantly lower than those in control group,while partial pressure of blood oxygen (PaO2) was higher than that in the control group (P＜0.05)； the medical compliance rate of observation group was 95%, which was significantly higher than 78.33% of the control group (χ2=7.212, P=0.007). Conclusion Continuous nursing care can obviously reduce the ICU reentry rate, it also can improve the physiological indexes and medical compliance behavior, which is worthy of clinical application. 2019 Vol. 26 (9): 247-249 [Abstract] ( 73 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 250 Application effect of TCM nursing in osteoporotic lumbar vertebral compression fractures FU Shao-yan； CAI Fei-yan； GONG Ting Objective To observe the application effect of TCM nursing in osteoporotic lumbar vertebral compression fractures （OVCF）. Methods According to the method of randomized parallel grouping, 68 patients with OVCF treated in our hospital from June 2017 to June 2018 were divided into group A and group B, 34 cases in each group. Group A was given TCM nursing and group B was given routine nursing. The psychological score (self-rating anxiety scale[SAS], self depression scale [SDS]), clinical related indexes (hospitalization time, hospitalization cost, visual analogue scale [VAS]） and total incidence complication rate were compared between the two groups. Results The SAS and SDS scores of group A were lower than those of group B, the differences were statistically significant(P＜0.05). The total incidence of complications in group A was significantly lower than that in group B (P＜0.05). The hospitalization time of group A was shorter than that of group B, and the hospitalization cost and VAS of group A was lower than that of group B, the differences were statistically significant (P＜0.05). TCM nursing intervention can improve the anxiety, depression and pain symptoms of OVCF patients, shorten the actual hospitalization days and reduce costs, and the incidence of complications, which has important clinical application and promotion value. 2019 Vol. 26 (9): 250-252 [Abstract] ( 62 ) HTML (29 KB)  PDF  (0 KB)  ( 11 )

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