慢性阻塞性肺疾病合并肺栓塞的短期预后及危险因素分析

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Abstract Objective To study the short-term prognosis andrisk factors for acute pulmonary embolism (PE)in patients with chronic obstructive pulmonary disease (COPD), to improve the early diagnosis rate of COPD with PE. Methods Forty-eight patients with COPD complicated with PE (as embolization group) and 50 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) (as control group) admitted to our hospital from January 2014 to July 2018 were selected as subjects for the study. The short-term prognosis and risk factors of COPD with PE were analyzed retrospectively. Results The bed time which was more than 3 days, lower limb asymmetric edema, chest pain, mortality and D-dimer, arterial partial pressure of oxygen (PaO2) and N-terminal brain natriuretic peptide (NT-proBNP) were compared between the two groups, the differences were statistically significant (P＜0.05). In the embolization group, the patients who died (n=9) of hypersensitive troponin T (hs-TnT) and NT-proBNP were higher than those of the survival(n=39), the differences were statistically significant (P＜0.05). Logistic regression analysis results showed that bed time≥3 d, asymmetric edema of lower limbs, D-dimer ≥2.0 μg/ml, PaO2＜60 mmHg and NT-proBNP ≥1200 pg/ml were risk factors for COPD with PE (P＜0.05). Conclusion Patients with COPD have ahigher incidence of PE if they have the risk factors of immobilization ≥3 days, asymmetric edema of lower limbs, D-dimer ≥2.0 μg/ml or PaO2 ＜60 mmHg,and cardiac dysfunction. If the levels of hs-TnT and NT-proBNP are significantly increased, their short-term prognosis is poor.

Key words： Chronic obstructive pulmonary disease Pulmonary embolism Short-term prognosis Risk factors

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	LIU Pian
	ZHUO Yu-juan

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LIU Pian,ZHUO Yu-juan. Short-term prognosis and risk factors of chronic obstructive pulmonary disease complicated with pulmonary embolism[J]. 中国当代医药, 2019, 26(9): 18-21.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I9/18

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