不同剂量糖皮质激素治疗系统性红斑狼疮的效果比较分析

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Abstract Objective To compare the effects of different doses of glucocorticoids in the treatment of systemic lupus erythematosus. Methods A total of 65 patients with systemic lupus erythematosus in our hospital from January 2013 to December 2017 were selected. According to the random number table method, they were divided into the control group(32 cases) and the observation group (33 cases). The control group was treated with small dose of glucocorticoid, while the observation group was treated with large dose of glucocorticoid. The clinical efficacy, the level of serum parathyroid hormone (PTH), bone mineral density (BMD), bone metabolism index, adverse reaction occurrence, and bone injury rate of the two groups were compared. Results The total clinical effectiveness rate, PTH level and bone injury rate in the observation group were all higher than those in the control group, with statistical significance (P＜0.05). The triangular BMD and bone-specific alkaline phosphatase in the observation group after treatment were lower than those in the control group, with statistical significance (P＜0.05). Conclusion The use of high-dose glucocorticoids in the treatment of systemic lupus erythematosus obtains a better effect compared with that in a small dose, which can improve bone metabolism, but is prone to bone damage. Therefore, it is necessary to choose a reasonable glucocorticoid with the consideration of specific clinical conditions.

Key words： Systemic lupus erythematosus Glucocorticoids Metabolism

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	CHEN Bo
	LIANG Jie

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CHEN Bo,LIANG Jie. Effect comparative analysis of different doses of glucocorticoids in the treatment of systemic lupus erythematosus[J]. 中国当代医药, 2019, 26(9): 76-78.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I9/76

[1]	徐攀.糖皮质激素冲击治疗对女性系统性红斑狼疮患者代谢及免疫功能的影响分析[J].中国民康医学，2018，30（21）：38-40.
[2]	李思吟，邓代华.系统性红斑狼疮皮疹治疗中糖皮质激素联合羟氯喹的临床价值研究[J].攀枝花学院学报，2018，35（5）：38-40.
[3]	龙洁，王涛，朱长亮.西药联合免疫吸附法治疗系统性红斑狼疮肾炎的效果及对炎性细胞因子和免疫功能的影响[J].中国医药导报，2018，15（24）：63-66.
[4]	唐辉英，佘定平，马颐姣.吗替麦考酚酯联合小剂量激素对系统性红斑狼疮的治疗效果和安全性分析[J].泰山医学院学报，2018，39（8）：850-852.
[5]	黄玉琼，张亚敏，陶娟.糖皮质激素在系统性红斑狼疮中的应用及研究现状[J].皮肤科学通报，2018，35（3）：296-304，238.
[6]	于晶.糖皮质激素联合环磷酰胺治疗重症系统性红斑狼疮的效果[J].中国当代医药，2018，25（10）：44-46.
[7]	汪少琼，殷建宝，栗洪波，等.糖皮质激素联合小剂量环磷酰胺治疗重症系统性红斑狼疮的效果分析[J].中国卫生标准管理，2018，9（3）：91-92.
[8]	王钢，李向培.糖皮质激素在系统性红斑狼疮目标治疗中的应用进展[J].安徽医科大学学报，2017，52（11）：1739-1743.
[9]	张旭凯.糖皮质激素联合来氟米特治疗系统性红斑狼疮临床观察[J].现代诊断与治疗，2017，28（11）：2009-2010.
[10]	许诚.不同剂量糖皮质激素治疗系统性红斑狼疮的临床疗效及对骨骼的影响[J].医学综述，2017，23（6）：1238-1241，1245.
[11]	张娜，王友莲.不同剂量糖皮质激素对系统性红斑狼疮患者糖代谢的影响[J].江西医药，2016，51（12）：1468-1469.
[12]	夏权斌.糖皮质激素在系统性红斑狼疮治疗中的应用[J].解放军预防医学杂志，2016，34（S2）：195.
[13]	郗建雄，邹延峰.糖皮质激素治疗系统性红斑狼疮致血脂异常的研究进展[J].安徽医药，2016，20（2）：205-209.
[14]	杨小兰.免疫吸附联合小剂量环磷酰胺及糖皮质激素治疗重症系统性红斑狼疮临床观察[J].内科，2015，10（5）：659-661.
[15]	余家静.不同剂量糖皮质激素维持治疗对系统性红斑狼疮患者骨密度及骨代谢的影响[D].蚌埠：蚌埠医学院，2015.